People_

Dr Zufu Lu

PhD (2009) VU University Amsterdam, The Netherlands

Principle Research Fellow/Associate Professor, School of Biomedical Engineering

Phone

+61 2 9351 8069

Fax

+61 2 9351 7060

Email

zufu.lu@sydney.edu.au

Address

J13 - Engineering Link Building

The University of Sydney

Details

Member of The University of Sydney Nano Institute

Websites

School of Biomedical Engineering

Biographical details

Dr Zufu Lu joined the group of Tissue Engineering and Biomaterials Research Unit, School of AMME at the University of Sydney, as a postdoctoral research fellow in 2009. In 2011 he was awarded an Early Career Fellow (ECR) by NHMRC, Australia. In 2019, he joined the new School of Biomedical Engineering, the University of Sydney.

Research interests

Dr Zufu Lu researches the factors involved in tissue microenvironments that are necessary for repair and regeneration, so he can recreate these microenvironments for tissue engineering repair and regeneration. This mainly includes understanding how the biological, chemical and physical factors in natural bone and cartilage tissue microenvironments affect the differentiation fate of mesenchymal stem cells and their underlying molecular mechanisms. His research has identified novel and innovative strategies, including the use of smart biomaterials and pharmaceutical molecules to modulate stem-cell fates for better bone regeneration outcomes, especially for the elderly.

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Current research students

Project title	Research student
Understanding and modulating the senescence-mediated osteoarthritis endotype.	Sidharth ARAVIND
Developing a universal machine learning model to detect cellular senescence in a variety of cells types	Rana JUDEH
To develop an anti-senescence nanoplatform in stem cells and investigate its underlying anti-senescence mechanism	Yiran ZHANG
Development of a novel technology platform for joint reconstruction	Daren ZHOU

Publications

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Book Chapters

Ramaswamy, Y., Lim, K., Zreiqat, H., Lu, Z. (2016). Stem Cells for Bone Regeneration: Role of Trophic Factors. In Alessandro Rozim Zorzi (Eds.), Advanced Techniques in Bone Regeneration. United Kingdom: IntechOpen. [More Information]
Lu, Z., Li, J., Zreiqat, H. (2015). Bone-Biomimetic Biomaterial and Cell Fate Determination. In Hala Zreiqat, Colin R. Dunstan, Vicki Rosen (Eds.), A Tissue Regneration Approach to Bone and Cartilage Repair, (pp. 119-146). Cham: Springer. [More Information]
Lu, Z., Roohaniesfahani, S., Zreiqat, H. (2014). Mimicking Bone Microenvironment for Directing Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation. In Gordana Vunjak-Novakovic, Kursad Turksen (Eds.), Biomimetics and Stem Cells: Methods and Protocols, (pp. 161-171). New York: Springer Science+Business Media. [More Information]

Journals

Entezari, A., Wu, Q., Mirkhalaf, M., Lu, Z., Roohani, I., Li, Q., Dunstan, C., Jiang, X., Zreiqat, H. (2024). Unraveling the influence of channel size and shape in 3D printed ceramic scaffolds on osteogenesis. Acta Biomaterialia, 180, 115-127. [More Information]
Zhang, Y., Jiang, F., Zhao, C., Cho, A., Fang, G., Cox, C., Zreiqat, H., Lu, Z., Lu, H., Ju, A. (2023). 3D spheroid-microvasculature-on-a-chip for tumor-endothelium mechanobiology interplay. Biomedical Materials, 18(5). [More Information]
Xu, Z., Zhang, Y., Lu, D., Zhang, G., Li, Y., Lu, Z., Wang, F., Wang, G. (2023). Antisenescence ZIF-8/Resveratrol Nanoformulation with Potential for Enhancement of Bone Fracture Healing in the Elderly. ACS Biomaterials Science and Engineering. [More Information]
Holmes, N., Roohani, I., Entezari, A., Guagliardo, P., Mirkhalaf Valashani, M., Lu, Z., Chen, Y., Yang, L., Dunstan, C., Zreiqat, H., Cairney, J. (2023). Discovering an unknown territory using atom probe tomography: Elemental exchange at the bioceramic scaffold/bone tissue interface. Acta Biomaterialia, 162, 199-210. [More Information]
Lu, Z., Jiang, L., Lesani, P., Zhang, W., Li, N., Luo, D., Li, Y., Ye, Y., Bian, J., Wang, G., Dunstan, C., Zreiqat, H., et al (2023). Nicotinamide Mononucleotide Alleviates Osteoblast Senescence Induction and Promotes Bone Healing in Osteoporotic Mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 78(2), 186-194. [More Information]
Lu, Z., Singh, G., Lesani, P., Zreiqat, H. (2022). Promise and Perspective of Nanomaterials in Antisenescence Tissue Engineering Applications. ACS Biomaterials Science and Engineering, 8(8), 3133-3141. [More Information]
Pham, D., Gangadoo, S., Lu, Z., Berndt, C., Newsom, E., Zreiqat, H., Truong, V., Ang, A. (2022). Strontium-doped hardystonite plasma sprayed coatings with robust antimicrobial activity. Materials Today Chemistry, 24. [More Information]
Lesani, P., Singh, G., Lu, Z., Mirkhalaf Valashani, M., New, E., Zreiqat, H. (2022). Two-photon ratiometric carbon dot-based probe for real-yime intracellular pH monitoring in 3D environment. Chemical Engineering Journal, 433, 133668. [More Information]
Pham, D., Berndt, C., Cizek, J., Gbureck, U., Zreiqat, H., Lu, Z., Ang, A. (2021). Baghdadite coating formed by hybrid water-stabilized plasma spray for bioceramic applications: Mechanical and biological evaluations. Materials Science and Engineering C, 122, 111873. [More Information]
Lesani, P., Mohamad Hadi, A., Lu, Z., Palomba, S., New, E., Zreiqat, H. (2021). Design principles and biological applications of red-emissive two-photon carbon dots. Communications Materials, 2(1), 108. [More Information]
No, Y., Nguyen, T., Lu, Z., Mirkhalaf Valashani, M., Fei, F., Foley, M., Zreiqat, H. (2021). Development of a bioactive and radiopaque bismuth doped baghdadite ceramic for bone tissue engineering. Bone, 153, 116147. [More Information]
Lesani, P., Lu, Z., Singh, G., Mursi, M., Mirkhalaf Valashani, M., New, E., Zreiqat, H. (2021). Influence of carbon dot synthetic parameters on photophysical and biological properties. Nanoscale, 13(25), 11138-11149. [More Information]
Roohaniesfahani, S., No, Y., Zuo, B., Xiang, S., Lu, Z., Liu, H., Plebanski, M., Zreiqat, H. (2021). Low-Temperature Synthesis of Hollow β-Tricalcium Phosphate Particles for Bone Tissue Engineering Applications. ACS Biomaterials Science and Engineering. [More Information]
Song, X., Liu, F., Qiu, C., Coy, E., Liu, H., Aperador, W., Załȩski, K., Li, J., Song, W., Lu, Z., et al (2021). Nanosurfacing Ti alloy by weak alkalinity-activated solid-state dewetting (AAD) and its biointerfacial enhancement effect. Materials Horizons, 8(3), 912-924. [More Information]
Ramaswamy, Y., Roohani, I., No, Y., Madafiglio, G., Chang, F., Zhang, F., Lu, Z., Zreiqat, H. (2021). Nature-inspired topographies on hydroxyapatite surfaces regulate stem cells behaviour. Bioactive Materials, 6(4), 1107-1117. [More Information]
Poon, K., Lu, Z., De Deene, Y., Ramaswamy, Y., Zreiqat, H., Singh, G. (2021). Tuneable manganese oxide nanoparticle based theranostic agents for potential diagnosis and drug delivery. Nanoscale Advances, 3(14), 4052-4061. [More Information]
Lu, Z., Zhang, W., No, Y., Lu, Y., Mirkhalaf Valashani, M., Rollet, P., Jiang, L., Ramaswamy, Y., Dunstan, C., Jiang, X., Zreiqat, H. (2020). Baghdadite Ceramics Prevent Senescence in Human Osteoblasts and Promote Bone Regeneration in Aged Rats. ACS Biomaterials Science and Engineering, 6(12), 6874-6885. [More Information]
Lu, Z., Chiu, J., Lee, L., Schindeler, A., Jackson, M., Ramaswamy, Y., Dunstan, C., Hogg, P., Zreiqat, H. (2020). Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7. Stem Cells Translational Medicine, 9(3), 403-415. [More Information]
Lesani, P., Singh, G., Viray, C., Ramaswamy, Y., Zhu, D., Kingshott, P., Lu, Z., Zreiqat, H. (2020). Two-Photon Dual-Emissive Carbon Dot-Based Probe: Deep-Tissue Imaging and Ultrasensitive Sensing of Intracellular Ferric Ions. ACS Applied Materials and Interfaces, 12(16), 18395-18406. [More Information]
No, Y., Holzmeister, I., Lu, Z., Prajapati, S., Shi, J., Gbureck, U., Zreiqat, H. (2019). Effect of Baghdadite Substitution on the Physicochemical Properties of Brushite Cements. Materials, 12(10), 1-15. [More Information]
Roohaniesfahani, S., Wang, J., No, Y., De Candia, C., Miao, X., Lu, Z., Shi, J., Kaplan, D., Jiang, X., Zreiqat, H. (2019). Modulatory effect of simultaneously released magnesium, strontium, and silicon ions on injectable silk hydrogels for bone regeneration. Materials Science and Engineering C, 94, 976-987. [More Information]
Lu, Z., Kleine-Nulend, J., Li, B. (2017). Bone Microenvironment, Stem Cells, and Bone Tissue Regeneration. Stem Cells International, 2017. [More Information]
Lu, Z., Chen, Y., Dunstan, C., Roohaniesfahani, S., Zreiqat, H. (2017). Priming Adipose Stem Cells with Tumor Necrosis Factor-Alpha Preconditioning Potentiates Their Exosome Efficacy for Bone Regeneration. Tissue Engineering - Part A, 23(21-22), 1212-1220. [More Information]
No, Y., Roohaniesfahani, S., Lu, Z., Shi, J., Zreiqat, H. (2017). Strontium-doped calcium silicate bioceramic with enhanced in vitro osteogenic properties. Biomedical Materials, 12(3), 2-10. [More Information]
Roohaniesfahani, S., No, Y., Lu, Z., Ng, P., Chen, Y., Shi, J., Pavlos, N., Zreiqat, H. (2016). A bioceramic with enhanced osteogenic properties to regulate the function of osteoblastic and osteocalastic cells for bone tissue regeneration. Biomedical Materials, 11(3), 1-12. [More Information]
Peeters, M., Huang, C., Vonk, L., Lu, Z., Bank, R., Helder, M., Doulabi, B. (2016). Optimisation of high-quality total ribonucleic acid isolation from cartilaginous tissues for real-time polymerase chain reaction analysis. Bone & Joint Research, 5(11), 560-568. [More Information]
Wang, G., Moya, S., Lu, Z., Gregurec, D., Zreiqat, H. (2015). Enhancing orthopedic implant bioactivity: Refining the Nanotopography. Nanomedicine, 10(8), 1327-1341. [More Information]
No, Y., Roohaniesfahani, S., Lu, Z., Schaer, T., Zreiqat, H. (2015). Injectable radiopaque and bioactive polycaprolactone-ceramic composites for orthopedic augmentation. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 103(7), 1465-1477. [More Information]
, Lu, Z., Roohaniesfahani, S., Church, T., Biro, M., Davies, B., King, A., MacKenzie, K., Minett, A., Zreiqat, H. (2015). Porous and strong three-dimensional carbon nanotube coated ceramic scaffolds for tissue engineering. Journal of Materials Chemistry B, 3(42), 8337-8347. [More Information]
Lu, Z., Roohaniesfahani, S., Li, J., Zreiqat, H. (2015). Synergistic effect of nanomaterials and BMP-2 signalling in inducing osteogenic differentiation of adipose tissue-derived mesenchymal stem cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 11(1), 219-228. [More Information]
Chen, Y., Roohaniesfahani, S., Lu, Z., Zreiqat, H., Dunstan, C. (2015). Zirconium Ions Up-Regulate the BMP/SMAD Signaling pathway and Promote the Proliferation and Differentiation of Human Osteoblasts. PloS One, 10(1), 1-17. [More Information]
Lu, Z., Wang, G., Roohaniesfahani, S., Dunstan, C., Zreiqat, H. (2014). Baghdadite Ceramics Modulate the Cross Talk Between Human Adipose Stem Cells and Osteoblasts for Bone Regeneration. Tissue Engineering - Part A, 20(5-6), 992-1002. [More Information]
Lu, Z., Wang, G., Zreiqat, H. (2014). Engineering Bone Niche Signals to Control Stem Cell Fate for Bone Tissue Regeneration. Archives of Stem Cell Research, 1(1), 1-2.
Roohaniesfahani, S., Wong, K., Lu, Z., Chen, Y., Li, J., Gronthos, S., Menicanin, D., Shi, J., Dunstan, C., Zreiqat, H. (2014). Fabrication of a novel triphasic and bioactive ceramic and evaluation of its in vitro and in vivo cytocompatibility and osteogenesis. Journal of Materials Chemistry B, 2(13), 1866-1878. [More Information]
Zhao, X., Wang, G., Zheng, H., Lu, Z., Cheng, X., Zreiqat, H. (2014). Refining naotopographical features on bone implant surfaces by altering surface chemical compositions. RSC Advances, 4(97), 54226-54234. [More Information]
Huang, F., Wu, X., Chen, J., Wang, W., Lu, Z. (2014). Resveratrol reverses multidrug resistance in human breast cancer doxorubicin-resistant cells. Experimental and Therapeutic Medicine, 7(6), 1611-1616. [More Information]
Lu, Z., Wang, G., Dunstan, C., Chen, Y., Lu, W., Davies, B., Zreiqat, H. (2013). Activation and Promotion of Adipose Stem Cells by Tumour Necrosis Factor-Alpha Preconditioning for Bone Regeneration. Journal of Cellular Physiology, 228(8), 1737-1744. [More Information]
Zhao, X., Wang, G., Zheng, H., Lu, Z., Zhong, X., Cheng, X., Zreiqat, H. (2013). Delicate refinement of surface nanotopography by adjusting TiO2 coating chemical composition for enhanced interfacial biocompatibility. ACS Applied Materials and Interfaces, 5(16), 8203-8209. [More Information]
Wang, G., Lu, Z., Zhao, X., Kondyurin, A., Zreiqat, H. (2013). Ordered HAp nanoarchitecture formed on HAp-TCP bioceramics by "nanocarving" and mineralization deposition and its potential use for guiding cell behaviors. Journal of Materials Chemistry B, 1(19), 2455-2462. [More Information]
Roohaniesfahani, S., Dunstan, C., Li, J., Lu, Z., Davies, B., Pearce, S., Field, J., Williams, R., Zreiqat, H. (2013). Unique microstructural design of ceramic scaffolds for bone regeneration under load. Acta Biomaterialia, 9(6), 7014-7024. [More Information]
Wang, G., Lu, Z., Xie, K., Lu, W., Roohaniesfahani, S., Kondyurin, A., Zreiqat, H. (2012). A facile method to in situ formation of hydroxyapatite single crystal architecture for enhanced osteoblast adhesion. Journal of Materials Chemistry, 22(36), 19081-19087. [More Information]
Lu, Z., Roohaniesfahani, S., Wang, G., Zreiqat, H. (2012). Bone biomimetic microenvironment induces osteogenic differentiation of adipose tissue-derived mesenchymal stem cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 8(4), 507-515. [More Information]
Roohaniesfahani, S., Lu, Z., Li, J., Ellis-Behnke, R., Kaplan, D., Zreiqat, H. (2012). Effect of self-assembled nanofibrous silk/polycaprolactone layer on the osteoconductivity and mechanical properties of biphasic calcium phosphate scaffolds. Acta Biomaterialia, 8(1), 302-312. [More Information]
Roohaniesfahani, S., Nouri-Khorasani, S., Lu, Z., Fathi, M., Razavi, M., Appleyard, R., Zreiqat, H. (2012). Modification of Porous Calcium Phosphate Surfaces with Different Geometries of Bioactive Glass Nanoparticles. Materials Science and Engineering C, 32(4), 830-839. [More Information]
Wang, G., Lu, Z., Dwarte, D., Zreiqat, H. (2012). Porous scaffolds with tailored reactivity modulate in-vitro osteoblast responses. Materials Science and Engineering C, 32(7), 1818-1826. [More Information]
Lu, Z., Wang, G., Dunstan, C., Zreiqat, H. (2012). Short-Term Exposure to Tumor Necrosis Factor-Alpha Enables Human Osteoblasts to Direct Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation. Stem Cells and Development, 21(13), 2420-2429. [More Information]
Zhong, X., Lu, Z., Valtchev, P., Wei, H., Zreiqat, H., Dehghani, F. (2012). Surface modification of poly(propylene carbonate) by aminolysis and layer-by-layer assembly for enhanced cytocompatibility. Colloids And Surfaces B: Biointerfaces, 93(1), 75-84. [More Information]
Roohaniesfahani, S., Nouri-Khorasani, S., Lu, Z., Appleyard, R., Zreiqat, H. (2011). Effects of Bioactive Glass Nanoparticles on the Mechanical and Biological Behavior of Composite Coated Scaffolds. Acta Biomaterialia, 7(3), 1307-1318. [More Information]
Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2011). Nanostructured glass-ceramic coatings for orthopaedic applications. Journal of the Royal Society Interface, 8(61), 1192-1203. [More Information]
Roohaniesfahani, S., Lu, Z., Zreiqat, H. (2011). Novel, simple and reproducible method for preparation of composite hierarchal porous structure scaffolds. Materials Letters, 65(17-18), 2578-2581. [More Information]
Lu, Z., Roohaniesfahani, S., Kwok, P., Zreiqat, H. (2011). Osteoblasts on Rod Shaped Hydroxyapatite Nanoparticles Incorporated PCL Film Provide an Optimal Osteogenic Niche for Stem Cell Differentiation. Tissue Engineering - Part A, 17(11/12), 1651-1661. [More Information]
Lu, Z., Zreiqat, H. (2010). Beta-tricalcium phosphate exerts osteoconductivity through Î±2Î²1 integrin and down-stream MAPK/ERK signaling pathway. Biochemical and Biophysical Research Communications, 394(2), 323-329. [More Information]
Lu, Z., Doulabi, B., Huang, C., Bank, R., Helder, M. (2010). Collagen Type II Enhances Chondrogenesis in Adipose Tissue-Derived Stem Cells by Affecting Cell Shape. Tissue Engineering - Part A, 16(1), 81-90. [More Information]
Zreiqat, H., Ramaswamy, Y., Wu, C., Paschalidis, A., Lu, Z., James, B., Birke, O., Mcdonald, M., Little, D., Dunstan, C. (2010). The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering. Biomaterials, 31(12), 3175-3184. [More Information]
Roohaniesfahani, S., Nouri-Khorasani, S., Lu, Z., Appleyard, R., Zreiqat, H. (2010). The influence hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL composites. Biomaterials, 31(21), 5498-5509. [More Information]
Lu, Z., Zreiqat, H. (2010). The Osteoconductivity of Biomaterials Is Regulated by Bone Morphogenetic Protein 2 Autocrine Loop Involving Î±2Î²1 Integrin and Mitogen-Activated Protein Kinase/Extracellular Related Kinase Signaling Pathways. Tissue Engineering - Part A, 16(10), 3075-3084. [More Information]
Hoogendoorn, R., Lu, Z., Kroeze, R., Bank, R., Wuisman, P., Helder, M. (2008). Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future. Journal of Cellular and Molecular Medicine, 12(6a), 2205-2216. [More Information]
Lu, Z., Doulabi, B., Wuisman, P., Bank, R., Helder, M. (2008). Influence of collagen type II and nucleus pulposus cells on aggregation and differentiation of adipose tissue-derived stem cells. Journal of Cellular and Molecular Medicine, 12(6B), 2812-2822. [More Information]
Lu, Z., Doulabi, B., Huang, C., Bank, R., Helder, M. (2008). Î²1 integrins regulate chondrogenesis and rock signaling in adipose stem cells. Biochemical and Biophysical Research Communications, 372(4), 547-552. [More Information]
Lu, Z., Doulabi, B., Wuisman, P., Bank, R., Helder, M. (2007). Differentiation of adipose stem cells by nucleus pulposus cells: configuration effect. Biochemical and Biophysical Research Communications, 359(4), 991-996. [More Information]
Wu, X., Lu, Z., Chen, J., Wang, J., Huang, F. (2007). Hepatic C-Fos expression is independent on oxidative stress and inflammation induced by acute cadmium exposure in rats. Annals Of Nutrition And Metabolism, 51(3), 258-263. [More Information]

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Conferences

Roohaniesfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Introducing Magnesium Silicate Based Scaffolds. International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration, China: Zhejiang University.
Roohaniesfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Magnesium Silicate Scaffolds: a New Candidate Biomaterial for Bone Regeneration (ID:3072). 9th World Biomaterials Congress, China: World Biomaterials Congress.
Roohaniesfahani, S., Lu, Z., Li, J., Appleyard, R., Zreiqat, H. (2010). Enhancing Mechanical and Biological Behavior of Strontium-Doped Hardystonite Scaffolds with Nanocomposite Coating. TERMIS 2010, Orlando, Florida, United States of America.
Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2010). Nanostructured Biomedical Coatings for Orthopaedic Applications. 3rd Sydney University Tissue Engineering Network Symposium SuTEN 2010, Australia: University of Sydney.
Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2010). Nanostructured glass-ceramic coatings for orthopaedic applications. 15th Annual Scientific Meeting of the Australian and New Zealand Orthopaedic Research Society ANZORS 2010, Australia: Australian and New Zealand Orthopaedic Research Society.
Li, J., Roohaniesfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Novel Silk-Modified Strontium-Hardystonite Composite Scaffolds for Skeletal Regeneration. TERMIS - North America 2010 Conference on Tissue Engineering & Regenerative Medicine International Society, USA: Tissue Engineering & Regenerative Medicine International Society.
Li, J., Roohaniesfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Silk-Modified Strontium-Hardystonite Scaffolds for Bone Tissue Engineering. 3rd Sydney University Tissue Engineering Network Symposium SuTEN 2010, Australia: University of Sydney.

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By Year

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2024

Entezari, A., Wu, Q., Mirkhalaf, M., Lu, Z., Roohani, I., Li, Q., Dunstan, C., Jiang, X., Zreiqat, H. (2024). Unraveling the influence of channel size and shape in 3D printed ceramic scaffolds on osteogenesis. Acta Biomaterialia, 180, 115-127. [More Information]

2023

Zhang, Y., Jiang, F., Zhao, C., Cho, A., Fang, G., Cox, C., Zreiqat, H., Lu, Z., Lu, H., Ju, A. (2023). 3D spheroid-microvasculature-on-a-chip for tumor-endothelium mechanobiology interplay. Biomedical Materials, 18(5). [More Information]
Xu, Z., Zhang, Y., Lu, D., Zhang, G., Li, Y., Lu, Z., Wang, F., Wang, G. (2023). Antisenescence ZIF-8/Resveratrol Nanoformulation with Potential for Enhancement of Bone Fracture Healing in the Elderly. ACS Biomaterials Science and Engineering. [More Information]
Holmes, N., Roohani, I., Entezari, A., Guagliardo, P., Mirkhalaf Valashani, M., Lu, Z., Chen, Y., Yang, L., Dunstan, C., Zreiqat, H., Cairney, J. (2023). Discovering an unknown territory using atom probe tomography: Elemental exchange at the bioceramic scaffold/bone tissue interface. Acta Biomaterialia, 162, 199-210. [More Information]
Lu, Z., Jiang, L., Lesani, P., Zhang, W., Li, N., Luo, D., Li, Y., Ye, Y., Bian, J., Wang, G., Dunstan, C., Zreiqat, H., et al (2023). Nicotinamide Mononucleotide Alleviates Osteoblast Senescence Induction and Promotes Bone Healing in Osteoporotic Mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 78(2), 186-194. [More Information]

show 1 more

2022

Lu, Z., Singh, G., Lesani, P., Zreiqat, H. (2022). Promise and Perspective of Nanomaterials in Antisenescence Tissue Engineering Applications. ACS Biomaterials Science and Engineering, 8(8), 3133-3141. [More Information]
Pham, D., Gangadoo, S., Lu, Z., Berndt, C., Newsom, E., Zreiqat, H., Truong, V., Ang, A. (2022). Strontium-doped hardystonite plasma sprayed coatings with robust antimicrobial activity. Materials Today Chemistry, 24. [More Information]
Lesani, P., Singh, G., Lu, Z., Mirkhalaf Valashani, M., New, E., Zreiqat, H. (2022). Two-photon ratiometric carbon dot-based probe for real-yime intracellular pH monitoring in 3D environment. Chemical Engineering Journal, 433, 133668. [More Information]

2021

Pham, D., Berndt, C., Cizek, J., Gbureck, U., Zreiqat, H., Lu, Z., Ang, A. (2021). Baghdadite coating formed by hybrid water-stabilized plasma spray for bioceramic applications: Mechanical and biological evaluations. Materials Science and Engineering C, 122, 111873. [More Information]
Lesani, P., Mohamad Hadi, A., Lu, Z., Palomba, S., New, E., Zreiqat, H. (2021). Design principles and biological applications of red-emissive two-photon carbon dots. Communications Materials, 2(1), 108. [More Information]
No, Y., Nguyen, T., Lu, Z., Mirkhalaf Valashani, M., Fei, F., Foley, M., Zreiqat, H. (2021). Development of a bioactive and radiopaque bismuth doped baghdadite ceramic for bone tissue engineering. Bone, 153, 116147. [More Information]
Lesani, P., Lu, Z., Singh, G., Mursi, M., Mirkhalaf Valashani, M., New, E., Zreiqat, H. (2021). Influence of carbon dot synthetic parameters on photophysical and biological properties. Nanoscale, 13(25), 11138-11149. [More Information]
Roohaniesfahani, S., No, Y., Zuo, B., Xiang, S., Lu, Z., Liu, H., Plebanski, M., Zreiqat, H. (2021). Low-Temperature Synthesis of Hollow β-Tricalcium Phosphate Particles for Bone Tissue Engineering Applications. ACS Biomaterials Science and Engineering. [More Information]
Song, X., Liu, F., Qiu, C., Coy, E., Liu, H., Aperador, W., Załȩski, K., Li, J., Song, W., Lu, Z., et al (2021). Nanosurfacing Ti alloy by weak alkalinity-activated solid-state dewetting (AAD) and its biointerfacial enhancement effect. Materials Horizons, 8(3), 912-924. [More Information]
Ramaswamy, Y., Roohani, I., No, Y., Madafiglio, G., Chang, F., Zhang, F., Lu, Z., Zreiqat, H. (2021). Nature-inspired topographies on hydroxyapatite surfaces regulate stem cells behaviour. Bioactive Materials, 6(4), 1107-1117. [More Information]
Poon, K., Lu, Z., De Deene, Y., Ramaswamy, Y., Zreiqat, H., Singh, G. (2021). Tuneable manganese oxide nanoparticle based theranostic agents for potential diagnosis and drug delivery. Nanoscale Advances, 3(14), 4052-4061. [More Information]

show 5 more

2020

Lu, Z., Zhang, W., No, Y., Lu, Y., Mirkhalaf Valashani, M., Rollet, P., Jiang, L., Ramaswamy, Y., Dunstan, C., Jiang, X., Zreiqat, H. (2020). Baghdadite Ceramics Prevent Senescence in Human Osteoblasts and Promote Bone Regeneration in Aged Rats. ACS Biomaterials Science and Engineering, 6(12), 6874-6885. [More Information]
Lu, Z., Chiu, J., Lee, L., Schindeler, A., Jackson, M., Ramaswamy, Y., Dunstan, C., Hogg, P., Zreiqat, H. (2020). Reprogramming of human fibroblasts into osteoblasts by insulin-like growth factor-binding protein 7. Stem Cells Translational Medicine, 9(3), 403-415. [More Information]
Lesani, P., Singh, G., Viray, C., Ramaswamy, Y., Zhu, D., Kingshott, P., Lu, Z., Zreiqat, H. (2020). Two-Photon Dual-Emissive Carbon Dot-Based Probe: Deep-Tissue Imaging and Ultrasensitive Sensing of Intracellular Ferric Ions. ACS Applied Materials and Interfaces, 12(16), 18395-18406. [More Information]

2019

No, Y., Holzmeister, I., Lu, Z., Prajapati, S., Shi, J., Gbureck, U., Zreiqat, H. (2019). Effect of Baghdadite Substitution on the Physicochemical Properties of Brushite Cements. Materials, 12(10), 1-15. [More Information]
Roohaniesfahani, S., Wang, J., No, Y., De Candia, C., Miao, X., Lu, Z., Shi, J., Kaplan, D., Jiang, X., Zreiqat, H. (2019). Modulatory effect of simultaneously released magnesium, strontium, and silicon ions on injectable silk hydrogels for bone regeneration. Materials Science and Engineering C, 94, 976-987. [More Information]

2017

Lu, Z., Kleine-Nulend, J., Li, B. (2017). Bone Microenvironment, Stem Cells, and Bone Tissue Regeneration. Stem Cells International, 2017. [More Information]
Lu, Z., Chen, Y., Dunstan, C., Roohaniesfahani, S., Zreiqat, H. (2017). Priming Adipose Stem Cells with Tumor Necrosis Factor-Alpha Preconditioning Potentiates Their Exosome Efficacy for Bone Regeneration. Tissue Engineering - Part A, 23(21-22), 1212-1220. [More Information]
No, Y., Roohaniesfahani, S., Lu, Z., Shi, J., Zreiqat, H. (2017). Strontium-doped calcium silicate bioceramic with enhanced in vitro osteogenic properties. Biomedical Materials, 12(3), 2-10. [More Information]

2016

Roohaniesfahani, S., No, Y., Lu, Z., Ng, P., Chen, Y., Shi, J., Pavlos, N., Zreiqat, H. (2016). A bioceramic with enhanced osteogenic properties to regulate the function of osteoblastic and osteocalastic cells for bone tissue regeneration. Biomedical Materials, 11(3), 1-12. [More Information]
Peeters, M., Huang, C., Vonk, L., Lu, Z., Bank, R., Helder, M., Doulabi, B. (2016). Optimisation of high-quality total ribonucleic acid isolation from cartilaginous tissues for real-time polymerase chain reaction analysis. Bone & Joint Research, 5(11), 560-568. [More Information]
Ramaswamy, Y., Lim, K., Zreiqat, H., Lu, Z. (2016). Stem Cells for Bone Regeneration: Role of Trophic Factors. In Alessandro Rozim Zorzi (Eds.), Advanced Techniques in Bone Regeneration. United Kingdom: IntechOpen. [More Information]

2015

Lu, Z., Li, J., Zreiqat, H. (2015). Bone-Biomimetic Biomaterial and Cell Fate Determination. In Hala Zreiqat, Colin R. Dunstan, Vicki Rosen (Eds.), A Tissue Regneration Approach to Bone and Cartilage Repair, (pp. 119-146). Cham: Springer. [More Information]
Wang, G., Moya, S., Lu, Z., Gregurec, D., Zreiqat, H. (2015). Enhancing orthopedic implant bioactivity: Refining the Nanotopography. Nanomedicine, 10(8), 1327-1341. [More Information]
No, Y., Roohaniesfahani, S., Lu, Z., Schaer, T., Zreiqat, H. (2015). Injectable radiopaque and bioactive polycaprolactone-ceramic composites for orthopedic augmentation. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 103(7), 1465-1477. [More Information]
, Lu, Z., Roohaniesfahani, S., Church, T., Biro, M., Davies, B., King, A., MacKenzie, K., Minett, A., Zreiqat, H. (2015). Porous and strong three-dimensional carbon nanotube coated ceramic scaffolds for tissue engineering. Journal of Materials Chemistry B, 3(42), 8337-8347. [More Information]
Lu, Z., Roohaniesfahani, S., Li, J., Zreiqat, H. (2015). Synergistic effect of nanomaterials and BMP-2 signalling in inducing osteogenic differentiation of adipose tissue-derived mesenchymal stem cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 11(1), 219-228. [More Information]
Chen, Y., Roohaniesfahani, S., Lu, Z., Zreiqat, H., Dunstan, C. (2015). Zirconium Ions Up-Regulate the BMP/SMAD Signaling pathway and Promote the Proliferation and Differentiation of Human Osteoblasts. PloS One, 10(1), 1-17. [More Information]

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2014

Lu, Z., Wang, G., Roohaniesfahani, S., Dunstan, C., Zreiqat, H. (2014). Baghdadite Ceramics Modulate the Cross Talk Between Human Adipose Stem Cells and Osteoblasts for Bone Regeneration. Tissue Engineering - Part A, 20(5-6), 992-1002. [More Information]
Lu, Z., Wang, G., Zreiqat, H. (2014). Engineering Bone Niche Signals to Control Stem Cell Fate for Bone Tissue Regeneration. Archives of Stem Cell Research, 1(1), 1-2.
Roohaniesfahani, S., Wong, K., Lu, Z., Chen, Y., Li, J., Gronthos, S., Menicanin, D., Shi, J., Dunstan, C., Zreiqat, H. (2014). Fabrication of a novel triphasic and bioactive ceramic and evaluation of its in vitro and in vivo cytocompatibility and osteogenesis. Journal of Materials Chemistry B, 2(13), 1866-1878. [More Information]
Lu, Z., Roohaniesfahani, S., Zreiqat, H. (2014). Mimicking Bone Microenvironment for Directing Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation. In Gordana Vunjak-Novakovic, Kursad Turksen (Eds.), Biomimetics and Stem Cells: Methods and Protocols, (pp. 161-171). New York: Springer Science+Business Media. [More Information]
Zhao, X., Wang, G., Zheng, H., Lu, Z., Cheng, X., Zreiqat, H. (2014). Refining naotopographical features on bone implant surfaces by altering surface chemical compositions. RSC Advances, 4(97), 54226-54234. [More Information]
Huang, F., Wu, X., Chen, J., Wang, W., Lu, Z. (2014). Resveratrol reverses multidrug resistance in human breast cancer doxorubicin-resistant cells. Experimental and Therapeutic Medicine, 7(6), 1611-1616. [More Information]

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2013

Lu, Z., Wang, G., Dunstan, C., Chen, Y., Lu, W., Davies, B., Zreiqat, H. (2013). Activation and Promotion of Adipose Stem Cells by Tumour Necrosis Factor-Alpha Preconditioning for Bone Regeneration. Journal of Cellular Physiology, 228(8), 1737-1744. [More Information]
Zhao, X., Wang, G., Zheng, H., Lu, Z., Zhong, X., Cheng, X., Zreiqat, H. (2013). Delicate refinement of surface nanotopography by adjusting TiO2 coating chemical composition for enhanced interfacial biocompatibility. ACS Applied Materials and Interfaces, 5(16), 8203-8209. [More Information]
Wang, G., Lu, Z., Zhao, X., Kondyurin, A., Zreiqat, H. (2013). Ordered HAp nanoarchitecture formed on HAp-TCP bioceramics by "nanocarving" and mineralization deposition and its potential use for guiding cell behaviors. Journal of Materials Chemistry B, 1(19), 2455-2462. [More Information]
Roohaniesfahani, S., Dunstan, C., Li, J., Lu, Z., Davies, B., Pearce, S., Field, J., Williams, R., Zreiqat, H. (2013). Unique microstructural design of ceramic scaffolds for bone regeneration under load. Acta Biomaterialia, 9(6), 7014-7024. [More Information]

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2012

Wang, G., Lu, Z., Xie, K., Lu, W., Roohaniesfahani, S., Kondyurin, A., Zreiqat, H. (2012). A facile method to in situ formation of hydroxyapatite single crystal architecture for enhanced osteoblast adhesion. Journal of Materials Chemistry, 22(36), 19081-19087. [More Information]
Lu, Z., Roohaniesfahani, S., Wang, G., Zreiqat, H. (2012). Bone biomimetic microenvironment induces osteogenic differentiation of adipose tissue-derived mesenchymal stem cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 8(4), 507-515. [More Information]
Roohaniesfahani, S., Lu, Z., Li, J., Ellis-Behnke, R., Kaplan, D., Zreiqat, H. (2012). Effect of self-assembled nanofibrous silk/polycaprolactone layer on the osteoconductivity and mechanical properties of biphasic calcium phosphate scaffolds. Acta Biomaterialia, 8(1), 302-312. [More Information]
Roohaniesfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Introducing Magnesium Silicate Based Scaffolds. International Forum of Biomedical Materials: Nanobiomaterials for Tissue Regeneration, China: Zhejiang University.
Roohaniesfahani, S., Wong, K., Lu, Z., Li, J., Zreiqat, H. (2012). Magnesium Silicate Scaffolds: a New Candidate Biomaterial for Bone Regeneration (ID:3072). 9th World Biomaterials Congress, China: World Biomaterials Congress.
Roohaniesfahani, S., Nouri-Khorasani, S., Lu, Z., Fathi, M., Razavi, M., Appleyard, R., Zreiqat, H. (2012). Modification of Porous Calcium Phosphate Surfaces with Different Geometries of Bioactive Glass Nanoparticles. Materials Science and Engineering C, 32(4), 830-839. [More Information]
Wang, G., Lu, Z., Dwarte, D., Zreiqat, H. (2012). Porous scaffolds with tailored reactivity modulate in-vitro osteoblast responses. Materials Science and Engineering C, 32(7), 1818-1826. [More Information]
Lu, Z., Wang, G., Dunstan, C., Zreiqat, H. (2012). Short-Term Exposure to Tumor Necrosis Factor-Alpha Enables Human Osteoblasts to Direct Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation. Stem Cells and Development, 21(13), 2420-2429. [More Information]
Zhong, X., Lu, Z., Valtchev, P., Wei, H., Zreiqat, H., Dehghani, F. (2012). Surface modification of poly(propylene carbonate) by aminolysis and layer-by-layer assembly for enhanced cytocompatibility. Colloids And Surfaces B: Biointerfaces, 93(1), 75-84. [More Information]

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2011

Roohaniesfahani, S., Nouri-Khorasani, S., Lu, Z., Appleyard, R., Zreiqat, H. (2011). Effects of Bioactive Glass Nanoparticles on the Mechanical and Biological Behavior of Composite Coated Scaffolds. Acta Biomaterialia, 7(3), 1307-1318. [More Information]
Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2011). Nanostructured glass-ceramic coatings for orthopaedic applications. Journal of the Royal Society Interface, 8(61), 1192-1203. [More Information]
Roohaniesfahani, S., Lu, Z., Zreiqat, H. (2011). Novel, simple and reproducible method for preparation of composite hierarchal porous structure scaffolds. Materials Letters, 65(17-18), 2578-2581. [More Information]
Lu, Z., Roohaniesfahani, S., Kwok, P., Zreiqat, H. (2011). Osteoblasts on Rod Shaped Hydroxyapatite Nanoparticles Incorporated PCL Film Provide an Optimal Osteogenic Niche for Stem Cell Differentiation. Tissue Engineering - Part A, 17(11/12), 1651-1661. [More Information]

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2010

Lu, Z., Zreiqat, H. (2010). Beta-tricalcium phosphate exerts osteoconductivity through Î±2Î²1 integrin and down-stream MAPK/ERK signaling pathway. Biochemical and Biophysical Research Communications, 394(2), 323-329. [More Information]
Lu, Z., Doulabi, B., Huang, C., Bank, R., Helder, M. (2010). Collagen Type II Enhances Chondrogenesis in Adipose Tissue-Derived Stem Cells by Affecting Cell Shape. Tissue Engineering - Part A, 16(1), 81-90. [More Information]
Roohaniesfahani, S., Lu, Z., Li, J., Appleyard, R., Zreiqat, H. (2010). Enhancing Mechanical and Biological Behavior of Strontium-Doped Hardystonite Scaffolds with Nanocomposite Coating. TERMIS 2010, Orlando, Florida, United States of America.
Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2010). Nanostructured Biomedical Coatings for Orthopaedic Applications. 3rd Sydney University Tissue Engineering Network Symposium SuTEN 2010, Australia: University of Sydney.
Wang, G., Lu, Z., Liu, X., Zhou, X., Ding, C., Zreiqat, H. (2010). Nanostructured glass-ceramic coatings for orthopaedic applications. 15th Annual Scientific Meeting of the Australian and New Zealand Orthopaedic Research Society ANZORS 2010, Australia: Australian and New Zealand Orthopaedic Research Society.
Li, J., Roohaniesfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Novel Silk-Modified Strontium-Hardystonite Composite Scaffolds for Skeletal Regeneration. TERMIS - North America 2010 Conference on Tissue Engineering & Regenerative Medicine International Society, USA: Tissue Engineering & Regenerative Medicine International Society.
Li, J., Roohaniesfahani, S., Lu, Z., Wang, G., Kaplan, D., Zreiqat, H. (2010). Silk-Modified Strontium-Hardystonite Scaffolds for Bone Tissue Engineering. 3rd Sydney University Tissue Engineering Network Symposium SuTEN 2010, Australia: University of Sydney.
Zreiqat, H., Ramaswamy, Y., Wu, C., Paschalidis, A., Lu, Z., James, B., Birke, O., Mcdonald, M., Little, D., Dunstan, C. (2010). The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering. Biomaterials, 31(12), 3175-3184. [More Information]
Roohaniesfahani, S., Nouri-Khorasani, S., Lu, Z., Appleyard, R., Zreiqat, H. (2010). The influence hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL composites. Biomaterials, 31(21), 5498-5509. [More Information]
Lu, Z., Zreiqat, H. (2010). The Osteoconductivity of Biomaterials Is Regulated by Bone Morphogenetic Protein 2 Autocrine Loop Involving Î±2Î²1 Integrin and Mitogen-Activated Protein Kinase/Extracellular Related Kinase Signaling Pathways. Tissue Engineering - Part A, 16(10), 3075-3084. [More Information]

show 7 more

2008

Hoogendoorn, R., Lu, Z., Kroeze, R., Bank, R., Wuisman, P., Helder, M. (2008). Adipose stem cells for intervertebral disc regeneration: current status and concepts for the future. Journal of Cellular and Molecular Medicine, 12(6a), 2205-2216. [More Information]
Lu, Z., Doulabi, B., Wuisman, P., Bank, R., Helder, M. (2008). Influence of collagen type II and nucleus pulposus cells on aggregation and differentiation of adipose tissue-derived stem cells. Journal of Cellular and Molecular Medicine, 12(6B), 2812-2822. [More Information]
Lu, Z., Doulabi, B., Huang, C., Bank, R., Helder, M. (2008). Î²1 integrins regulate chondrogenesis and rock signaling in adipose stem cells. Biochemical and Biophysical Research Communications, 372(4), 547-552. [More Information]

2007

Lu, Z., Doulabi, B., Wuisman, P., Bank, R., Helder, M. (2007). Differentiation of adipose stem cells by nucleus pulposus cells: configuration effect. Biochemical and Biophysical Research Communications, 359(4), 991-996. [More Information]
Wu, X., Lu, Z., Chen, J., Wang, J., Huang, F. (2007). Hepatic C-Fos expression is independent on oxidative stress and inflammation induced by acute cadmium exposure in rats. Annals Of Nutrition And Metabolism, 51(3), 258-263. [More Information]

Selected Grants

2022

An anti-senescence nanoplatform and its underlying mechanism, Zreiqat H, Singh G, Lu Z, Australian Research Council (ARC)/Discovery Projects (DP)

2016

Mesenchymal Stem Cell-Derived Exosomes as Critical Therapeutic Agents for Bone Repairing and Regeneration, Lu Z, DVC Research/Bridging Support Fellowship

2014

Harnessing Mesenchymal Stem cell therapeutics for Bone Regeneration by Tumour Necrosis Factor-alpha, Lu Z, Zreiqat H, Perpetual Trustees Charitable Trusts/Research Support

2013

CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility, Allbutt H, Ammit A, Assinder S, Bao B, Barrs V, Black J, Brennan-Speranza T, Buckland M, Burgess J, Byrne M, Camp A, Christopherson R, Codd R, Day M, de Graaf S, Dixon K, Dong Q, Dos Remedios C, Fraser S, Fu D, Goldsbury C, Groundwater P, Halliday G, Hambly B, Hardikar A, Hibbs D, Ho P, Hong A, Huang M, Huq F, Jansson P, Johnstone D, Joshua D, Ju Y, Kalinowski D, King N, Kovacevic Z, Kril J, Lai D, Lane D, Lay P, Lee C, Lok H, Lovicu F, Lu Z, Lyons J, Mason R, McLennan S, Morris B, Murphy C, Murray M, Naylor M, Oliver B, Owens T, Poronnik P, Rendina L, Richardson D, Ryan R, Sahni S, Scolyer R, Shafie N, Sharland A, Slobedman B, Sunde M, Sutherland G, Triccas J, Williamson P, Zhu L, Zreiqat H, National Health and Medical Research Council (NHMRC)/Equipment Grant

2012

QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility, Ammit A, Bagley E, Bao B, Boyer M, Byrne M, Camp A, Day M, Dong Q, Dos Remedios C, Fraser S, Fu D, Hanrahan J, Hibbs D, Huang M, Jansson P, Ju Y, Kovacevic Z, Kril J, Lai D, Lane D, Lay P, Lyons J, Morris B, Murphy C, Rendina L, Richardson D, Sutherland G, Vandenberg R, Whittington R, Zhang D, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B, National Health and Medical Research Council (NHMRC)/Equipment Grant

2011

Smart synthetic biomaterial for bone tissue regeneration, Lu Z, National Health and Medical Research Council (NHMRC)/Early Career Fellowships

Faculty of Engineering

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Dr Zufu Lu

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