Associate Professor Amanda Salis

NHMRC Senior Research Fellow
Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders, Sydney Medical School

Telephone +61 423 777 801
Fax +61 2 9036 3176

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Biographical details

With a BSc (Hons) from the University of Western Australia and a PhD from the University of Geneva, Switzerland, Associate Professor Amanda Salis (nee Sainsbury) leads a research team at The Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders that aims to help people to attain and maintain an optimum body weight and composition. Adept in translating novel research findings into human benefits, Amanda's research into hypothalamic control of energy homeostasis spans studies with conditional transgenic mice to randomized controlled clinical trials in humans. Many of Amanda's first or senior-author publications are in highly esteemed journals such as Proceedings of the National Academy of Sciences of the USA, The Journal of Clinical Investigation, Genes & Development, Diabetes, or Cell Metabolism. Photo credit: mlai.org

Research interests

Would you like to participate in one of my clinical weight loss trials?

My collaborators and I are currently recruiting participants living in the Sydney metropolitan area for three weight loss trials. Please click on the following links for more information:

The TEMPO Diet Trial

The PREVIEW Study Australia

HAPIFED Weight Management and Eating Disorder Program

Non-surgical obesity treatments are ineffective for most, in part due to adaptive responses to energy restriction that increase appetite and reduce metabolic rate. Not only do these adaptations oppose ongoing weight loss, they may also adversely affect body composition via hormonal changes that favor abdominal fat accretion with loss of muscle mass and bone. Thus, current obesity treatments may inadvertently increase the risk of metabolic complications such as diabetes and cardiovascular disease, as well as that of structural diseases such as sarcopenia and osteoporosis. My long-term objective is to find ways to attenuate these adaptive responses so that more people can attain and maintain a healthy body weight and composition. The focus of my recent NHMRC Career Development Award (2008-2011) was to identify brain pathways mediating these adaptive responses to energy restriction and their effects on fat, muscle and bone, predominantly using transgenic mice at the Garvan Institute of Medical Research. Building on the successful outcomes of this work, in March 2012 I joined The University of Sydney in order to apply this knowledge to clinical practice for more immediate benefit to human health. My team will determine the consequences of adaptive responses to energy restriction on body composition in obese patients, using state-of-the-art sensitive techniques. This project is supported by an NHMRC Project Grant on which I am CIA (APP1026005, 2012-2015). We will additionally test novel ways of attenuating the adaptive responses to energy restriction in humans, using ketogenic diets (APP1026005) and intermittent energy restriction (NHMRC Project Grant APP1030705, 2012-2014). This transformative research offers the potential to aggressively improve human obesity treatments within the ensuing 10 years.

Teaching and supervision

Would you like to find out what it's like doing obesity research?
Besides Honours, Masters and PhD supervision, I provide short-term part-time or full-time research training opportunities for people wishing to experience clinical obesity research. These opportunities are designed to fit around your work or study commitments.
Benefits

  • Boost your CV by gaining real-world research experience in an internationally recognised multidisciplinary research environment dedicated to reducing obesity and associated complications.
  • Find out whether you like research before committing to longer-term research activities, such as an Honours degree, Masters, Doctorate or a PhD.
  • Network with professionals in the field of obesity, nutrition, exercise and eating disorders and identify future opportunities (e.g. research projects, scholarships, jobs, collaborations).
  • Participate in the Boden Institute's Research Training Program. This involves weekly Journal Clubs (currently Mondays at 1.30 pm to 2.30 pm), where you can learn to read and critically appraise scientific literature and health claims in the fields of nutrition, physical activity, weight regulation, eating disorders and disease prevention, as well as occasional workshops that teach the skills of writing scientific research reports or applying for scholarships and jobs.

To apply
Please e-mail the following to Associate Professor Amanda Salis (amanda.salis@sydney.edu.au):

  • A cover letter outlining why you are interested in this research training opportunity, and the number of hours (between 7.30 am and 6 pm), days (Mon-Fri) and available start and end dates.
  • Your curriculum vitae including the contact details of your referees.
  • Your academic transcript(s), or other document(s) that include grades achieved in your current and / or previous degree(s).

Trainees are selected on the basis of academic merit, motivation for obesity research, clarity about how the research training opportunity will aid future career plans, and availability relative to current project requirements.

Selected grants

2014

  • Cancer anorexia/cachexia: Mechanisms for anorexia and appetite regulation by tumour derived MIC-1/GDF15; Breit S, Lin S, Salis A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Gold-standard assessment of energy expenditure and aerobic fitness during interventions to prevent diabetes; Salis A, Markovic T, Caterson I, Brand-Miller J, Grunstein R, Johnson N; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • The intermittent very low calorie diet trial; Salis A; DVC Research/Bridging Support Grant.

2013

  • Achieving more effective weight loss with intermittent energy restriction; Byrne N, Salis A, Hickman I, Hills A, King N; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Improving weight loss outcomes; Salis A; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.
  • The University of Sydney Core Facility for Human Body Composition Assessment; Salis A, Caterson I, Brand-Miller J, Simpson S, Tam C, Johnson N, Grunstein R; DVC Research/Equipment Grant.
  • Diabetes research project; Salis A, Caterson I, Brand-Miller J, Simpson S, Johnson N, Franklin J, Yee B; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2012

  • Adaptive responses to energy restriction in humans; Salis A; DVC Research/Bridging Support Fellowship.
  • Long-term effects of very low energy diet versus conventional diet on adiposity, lean body mass, muscle strength and bone density in obese adults, and mechanisms promoting changes; Salis A, Byrne N, Caterson I; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

Download citations: PDF RTF Endnote

Books

  • Salis, A. (2012). Don't Go Hungry for Life. Sydney: Random House Australia.
  • Salis, A. (2007). The Don’t Go Hungry Diet. Australia: Bantam Australia.

Book Chapters

  • Salis, A. (2012). The Biology of Weight Control. In Louise A. Baur, Stephen M. Twigg, Roger S.Magnusson (Eds.), A Modern Epidemic: Expert Perspectives on Obesity and Diabetes, (pp. 3-19). Sydney, Australia: Sydney University Press.

Journals

  • Salis, A., Hay, P. (2014). Call for an urgent rethink of the 'health at every size' concept. Journal of Eating Disorders, 2(8), 1-4. [More Information]
  • Nguyen, A., Slack, K., Schwarzer, C., Lee, N., Boey, D., Macia, L., Yulyaningsih, E., Enriquez, R., Zhang, L., Lin, S., Salis, A., et al (2014). Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice. Neuropeptides, 48(3), 143-151. [More Information]
  • Shi, Y., Lau, J., Lin, Z., Zhang, H., Zhai, L., Sperk, G., Heilbronn, R., Mietzsch, M., Weger, S., Huang, X., Salis, A., et al (2013). Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN. Cell Metabolism, 17(2), 236-248. [More Information]
  • Brzozowska, M., Salis, A., Eisman, J., Baldock, P., Center, J. (2013). Bariatric surgery, bone loss, obesity and possible mechanisms. Obesity Reviews, 14(1), 52-67. [More Information]
  • Seimon, R., Hostland, N., Silveira, S., Gibson, A., Salis, A. (2013). Effects of energy restriction on activity of the hypothalamo-pituitary-adrenal axis in obese humans and rodents: implications for diet-induced changes in body composition. Hormone Molecular Biology and Clinical Investigation, 15(2), 71-80. [More Information]
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis, A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]
  • Wong, I., Nguyen, A., Khor, E., Enriquez, R., Eisman, J., Sainsbury, A., Herzog, H., Baldock, P. (2013). Neuropeptide Y Is a Critical Modulator of Leptin’s Regulation of Cortical Bone. Journal of Bone and Mineral Research, 28(4), 886-898. [More Information]
  • Zengin, A., Nguyen, A., Wong, I., Zhang, L., Enriquez, R., Eisman, J., Herzog, H., Baldock, P., Salis, A. (2013). Neuropeptide Y mediates the short-term hypometabolic effect of estrogen deficiency in mice. International Journal of Obesity, 37(3), 390-398. [More Information]
  • Purtell, L., Jenkins, A., Viardot, A., Herzog, H., Salis, A., Smith, A., Loughnan, G., Steinbeck, K., Campbell, L., Sze, L. (2013). Postprandial cardiac autonomic function in Prader-Willi syndrome. Clinical Endocrinology, 79(1), 128-133. [More Information]
  • Shi, Y., Lin, Z., Lau, J., Zhang, H., Yagi, M., Kanzler, I., Salis, A., Herzog, H., Lin, S. (2013). PYY3-36 and pancreatic polypeptide reduce food intake in an additive manner via distinct hypothalamic dependent pathways in mice. Obesity, 21(12), E669-E678. [More Information]
  • Tsai, V., Macia, L., Johnen, H., Kuffner, T., Manadhar, R., Jorgensen, S., Lee-Ng, K., Zhang, H., Wu, L., Marquis, C., Salis, A., et al (2013). TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator. PLoS One, 8(2), e55174. [More Information]
  • Shi, Y., Hammerle, C., Lee, I., Turner, N., Nguyen, A., Riepler, S., Lin, S., Salis, A., Herzog, H., Zhang, L. (2012). Adult-onset PYY overexpression in mice reduces food intake and increases lipogenic capacity. Neuropeptides, 46(4), 173-182. [More Information]
  • Tsai, V., Husaini, Y., Manandhar, R., Lee-Ng, K., Zhang, H., Harriott, K., Jiang, L., Lin, S., Salis, A., Brown, D., et al (2012). Anorexia/cachexia of chronic diseases: a role for the TGF-beta family cytokine MIC-1/GDF15. Journal of Cachexia, Sarcopenia and Muscle, 3(4), 239-243. [More Information]
  • Laurence, M., Tsai, V., Nguyen, A., Johnen, H., Kuffner, T., Shi, Y., Lin, S., Herzog, H., Brown, D., Breit, S., Salis, A. (2012). Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets. PLoS One, 7(4), 1-8. [More Information]
  • Breit, S., Carrero, J., Tsai, V., Yagoutifam, N., Luo, W., Kuffner, T., Bauskin, A., Wu, L., Jiang, L., Barany, P., Salis, A., et al (2012). Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease. Nephrology, Dialysis, Transplantation, 27(1), 70-75. [More Information]
  • Sousa, D., Baldock, P., Enriquez, R., Zhang, L., Salis, A., Lamghari, M., Herzog, H. (2012). Neuropeptide Y Y1 receptor antagonism increases bone mass in mice. Bone, 51(1), 8-16. [More Information]
  • Macia, L., Yulyaningsih, E., Pangon, L., Nguyen, A., Lin, S., Shi, Y., Zhang, L., Bijker, M., Grey, S., Mackay, F., Salis, A., et al (2012). Neuropeptide Y1 Receptor in Immune Cells Regulates Inflammation and Insulin Resistance Associated With Diet-Induced Obesity. Diabetes, 61(12), 3228-3238. [More Information]
  • Zhang, L., Nguyen, A., Lee, I., Yulyaningsih, E., Riepler, S., Stehrer, B., Enriquez, R., Lin, S., Shi, Y., Baldock, P., Salis, A., et al (2012). NPY modulates PYY function in the regulation of energy balance and glucose homeostasis. Diabetes, Obesity and Metabolism, 14(8), 727-736. [More Information]
  • Lee, N., Nguyen, A., Enriquez, R., Doyle, K., Sainsbury, A., Baldock, P., Herzog, H. (2012). Osteoblast specific Y1 receptor deletion enhances bone mass. Bone, 48(3), 461-467. [More Information]
  • Wong, I., Driessler, F., Khor, E., Shi, Y., Hormer, B., Nguyen, A., Enriquez, R., Eisman, J., Salis, A., Herzog, H., et al (2012). Peptide YY Regulates Bone Remodeling in Mice: A Link between Gut and Skeletal Biology. PLoS One, 7(7), 1-12. [More Information]
  • Salis, A., Zhang, L. (2012). Role of the hypothalamus in the neuroendocrine regulation of body weight and composition during energy deficit. Obesity Reviews, 13(3), 234-257. [More Information]
  • Baldock, P., Driessler, F., Lin, S., Wong, I., Shi, Y., Yulyaningsih, E., Castillo, L., Janmaat, S., Enriquez, R., Zengin, A., Salis, A., et al (2012). The endogenous opioid dynorphin is required for normal bone homeostasis in mice. Neuropeptides, 46(6), 383-394. [More Information]
  • Chesworth, R., Yulyaningsih, E., Cappas, E., Arnold, J., Salis, A., Karl, T. (2012). The response of neuregulin 1 mutant mice to acute restraint stress. Neuroscience Letters, 515(1), 82-86. [More Information]
  • Nguyen, A., Mitchell, N., Lin, S., Macia, L., Yulyaningsih, E., Baldock, P., Enriquez, R., Zhang, L., Shi, Y., Zolotukhin, S., Salis, A., et al (2012). Y1 and Y5 Receptors are Both Required for the Regulation of Food Intake and Energy Homeostasis in Mice. PLoS One, 7(6), 1-16. [More Information]
  • Preston, E., Cooney, G., Wilks, D., Baran, K., Zhang, L., Kraegen, E., Salis, A. (2011). Central neuropeptide Y infusion and melanocortin 4 receptor antagonism inhibit thyrotropic function by divergent pathways. Neuropeptides, 45(6), 407-415. [More Information]
  • Sze, L., Purtell, L., Jenkins, A., Loughnan, G., Smith, E., Herzog, H., Salis, A., Steinbeck, K., Campbell, L., Viardot, A. (2011). Effects of a Single Dose of Exenatide on Appetite, Gut Hormones, and Glucose Homeostasis in Adults with Prader-Willi Syndrome. Journal of Clinical Endocrinology and Metabolism, 96(8), E1314-E1319. [More Information]
  • Purtell, L., Sze, L., Loughnan, G., Smith, E., Herzog, H., Sainsbury, A., Steinbeck, K., Campbell, L., Viardot, A. (2011). In adults with Prader-Willi syndrome, elevated ghrelin levels are more consistent with hyperphagia than high PYY and GLP-1 levels. Neuropeptides, 45(4), 301-307. [More Information]
  • Nguyen, A., Herzdog, H., Sainsbury, A. (2011). Neuropeptide Y and peptide YY: important regulators of energy metabolism. Current Opinion in Endocrinology, Diabetes, and Obesity, 18(1), 56-60. [More Information]
  • Yulyaningsih, E., Zhang, L., Herzog, H., Salis, A. (2011). NPY receptors as potential targets for anti-obesity drug development. British Journal of Pharmacology, 163(6), 1170-1202. [More Information]
  • Shi, Y., Lin, S., Castillo, L., Aljanova, A., Enriquez, R., Baldock, P., Nguyen, A., Zhang, L., Bijker, M., Macia, L., Salis, A., et al (2011). Peripheral-Specific Y2 Receptor Knockdown Protects Mice From High-Fat Diet-Induced Obesity. Obesity, 19(11), 2137-7148. [More Information]
  • Lau, S., Lin, S., Stokes, R., Cheng, K., Baldock, P., Enriquez, R., Mclean, M., Cheung, N., Sainsbury, A., Gonzalez, F., Gunton, J., et al (2011). Synergistic effects of genetic beta cell dysfunction and maternal glucose intolerance on offspring metabolic phenotype in mice. Diabetologia: clinical and experimental diabetes and metabolism, 54(4), 910-921. [More Information]
  • Lee, N., Allison, S., Enriquez, R., Sainsbury, A., Herzog, H., Baldock, P. (2011). Y2 and Y4 receptor signalling attenuates the skeletal response of central NPY. Journal of Molecular Neuroscience, 43(2), 123-131. [More Information]
  • Lin, E., Zhang, L., Sainsbury, A., Herzog, H. (2011). Y2, Y4 receptors and obesity. Expert Review of Endocrinology and Metabolism, 2, 2. [More Information]
  • Zhou, Y., Lee, N., Nguyen, A., Enriquez, R., Riepler, S., Stehrer, B., Zanchetta, J., Baldock, P., Herzog, H., Salis, A., et al (2010). Additive actions of the cannabinoid and neuropeptide Y systems on adiposity and lipid oxidation. Diabetes, Obesity and Metabolism, 12(7), 591-603. [More Information]
  • Lee, N., Doyle, K., Salis, A., Enriquez, R., Hort, Y., Riepler, S., Baldock, P., Herzog, H. (2010). Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity. Journal of Bone and Mineral Research, 25, 1736-1747. [More Information]
  • Zengin, A., Zhang, L., Herzog, H., Baldock, P., Salis, A. (2010). Neuropeptide Y and sex hormone interactions in humoral and neuronal regulation of bone and fat. Trends in Endocrinology and Metabolism, 21, 411-418. [More Information]
  • Shi, Y., Lin, S., Wong, I., Baldock, P., Aljanova, A., Enriquez, R., Castillo, L., Mitchell, N., Ye, J., Zhang, L., Salis, A., et al (2010). NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice. PLoS One, 5(6), 1-16. [More Information]
  • Cox, H., Tough, I., Woolston, A., Zhang, L., Nguyen, A., Salis, A., Herzog, H. (2010). Peptide YY is critical for acylethanolamine receptor Gpr119-induced activation of gastrointestinal mucosal responses. Cell Metabolism, 11, 532-542. [More Information]
  • Viardot, A., Sze, L., Purtell, L., Sainsbury, A., Loughnan, G., Smith, E., Herzog, H., Steinbeck, K., Campbell, L. (2010). Prader-Willi Syndrome Is Associated with Activation of the Innate Immune System Independently of Central Adiposity and Insulin Resistance. Journal of Clinical Endocrinology and Metabolism, 95(7), 3392-3399. [More Information]
  • Zhang, L., Riepler, S., Turner, N., Enriquez, R., Lee, I., Baldock, P., Herzog, H., Salis, A. (2010). Y2 and Y4 receptor signaling synergistically act on energy expenditure and physical activity. American Journal of Physiology, 299, R1618-R1628. [More Information]
  • Salis, A., Shi, Y., Zhang, L., Aljanova, A., Lin, Z., Nguyen, A., Herzog, H., Lin, S. (2010). Y4 receptors and pancreatic polypeptide regulate food intake via hypothalamic orexin and brain-derived neurotropic factor dependent pathways. Neuropeptides, 44, 261-268. [More Information]
  • Allison, S., Baldock, P., Enriquez, R., Lin, E., During, M., Gardiner, E., Eisman, J., Salis, A., Herzog, H. (2009). Critical interplay between neuropeptide Y and sex steroid pathways in bone and adipose tissue homeostasis. Journal of Bone and Mineral Research, 24(2), 294-304. [More Information]
  • Lin, S., Shi, Y., Yulyaningsih, E., Aljanova, A., Zhang, L., Macia, L., Nguyen, A., Lin, E., During, M., Herzog, H., Salis, A. (2009). Critical role of arcuate y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice. PLoS One, 4(12), e8488-e8488. [More Information]
  • Salis, A., Zhang, L. (2009). Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit. Molecular And Cellular Endocrinology, 316, 109-119. [More Information]
  • Lovejoy, J., Salis, A. (2009). Sex differences in obesity and the regulation of energy homeostasis. Obesity Reviews, 10, 154-167. [More Information]
  • Boey, D., Lin, S., Enriquez, R., Lee, N., Slack, K., Couzens, M., Baldock, P., Herzog, H., Salis, A. (2008). PYY transgenic mice are protected against diet-induced and genetic obesity. Neuropeptides, 42(1), 19-30. [More Information]
  • Lee, N., Enriquez, R., Boey, D., Lin, S., Slack, K., Baldock, P., Herzog, H., Salis, A. (2008). Synergistic attenuation of obesity by Y2- and Y4-receptor double knockout in ob/ob mice. Nutrition, 24, 892-899. [More Information]
  • Salis, A., Lin, S., McNamara, K., Slack, K., Enriquez, R., Lee, N., Boey, D., Smythe, G., Schwarzer, C., Baldock, P., et al (2007). Dynorphin knockout reduces fat mass and increases weight loss during fasting in mice. Molecular Endocrinology, 21(7), 1722-1735. [More Information]
  • Lin, S., Lin, E., Boey, D., Lee, N., Slack, K., During, M., Salis, A., Herzog, H. (2007). Fasting inhibits the growth and reproductive axes via distinct Y2 and Y4 receptor-mediated pathways. Endocrinology, 148(5), 2056-2065. [More Information]
  • Lundberg, P., Allison, S., Lee, N., Baldock, P., Brouard, N., Rost, S., Enriquez, R., Salis, A., Lamghari, M., Simmons, P., et al (2007). Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1 receptor expression. Journal of Biological Chemistry, 282(26), 19082-19091. [More Information]
  • Baldock, P., Allison, S., Lundberg, P., Lee, N., Slack, K., Lin, E., Enriquez, R., McDonald, M., Zhang, L., During, M., Little, D., et al (2007). Novel role of y1 receptors in the coordinated regulation of bone and energy homeostasis. Journal of Biological Chemistry, 282(26), 19092-19102. [More Information]
  • Boey, D., Salis, A., Herzog, H. (2007). The role of peptide YY in regulating glucose homeostasis. Peptides, 28(2), 390-395. [More Information]
  • Johnen, H., Lin, S., Kuffner, T., Brown, D., Tsai, V., Bauskin, A., Wu, L., Pankhurst, G., Jiang, L., Junankar, S., Salis, A., et al (2007). Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nature Medicine, 13(11), 1333-1340. [More Information]
  • Lin, E., Lee, N., Slack, K., Karl, T., Duffy, L., O'Brien, E., Matsumoto, I., Dedova, I., Herzog, H., Sainsbury, A. (2006). Distinct endocrine effects of chronic haloperidol or risperidone administration in male rats. Neuropharmacology, 51(7-8), 1129-1136. [More Information]
  • Baldock, P., Allison, S., McDonald, M., Sainsbury, A., Enriquez, R., Little, D., Eisman, J., Gardiner, E., Herzog, H. (2006). Hypothalamic regulation of cortical bone mass: opposing activity of Y2 receptor and leptin pathways. Journal of Bone and Mineral Research, 21(10), 1600-1607. [More Information]
  • Wheway, J., Mackay, C., Newton, R., Sainsbury, A., Boey, D., Herzog, H., Mackay, F. (2005). A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. The Journal of Experimental Medicine, 202(11), 1527-1538. [More Information]

2014

  • Salis, A., Hay, P. (2014). Call for an urgent rethink of the 'health at every size' concept. Journal of Eating Disorders, 2(8), 1-4. [More Information]
  • Nguyen, A., Slack, K., Schwarzer, C., Lee, N., Boey, D., Macia, L., Yulyaningsih, E., Enriquez, R., Zhang, L., Lin, S., Salis, A., et al (2014). Double deletion of orexigenic neuropeptide Y and dynorphin results in paradoxical obesity in mice. Neuropeptides, 48(3), 143-151. [More Information]

2013

  • Shi, Y., Lau, J., Lin, Z., Zhang, H., Zhai, L., Sperk, G., Heilbronn, R., Mietzsch, M., Weger, S., Huang, X., Salis, A., et al (2013). Arcuate NPY controls sympathetic output and BAT function via a relay of tyrosine hydroxylase neurons in the PVN. Cell Metabolism, 17(2), 236-248. [More Information]
  • Brzozowska, M., Salis, A., Eisman, J., Baldock, P., Center, J. (2013). Bariatric surgery, bone loss, obesity and possible mechanisms. Obesity Reviews, 14(1), 52-67. [More Information]
  • Seimon, R., Hostland, N., Silveira, S., Gibson, A., Salis, A. (2013). Effects of energy restriction on activity of the hypothalamo-pituitary-adrenal axis in obese humans and rodents: implications for diet-induced changes in body composition. Hormone Molecular Biology and Clinical Investigation, 15(2), 71-80. [More Information]
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis, A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]
  • Wong, I., Nguyen, A., Khor, E., Enriquez, R., Eisman, J., Sainsbury, A., Herzog, H., Baldock, P. (2013). Neuropeptide Y Is a Critical Modulator of Leptin’s Regulation of Cortical Bone. Journal of Bone and Mineral Research, 28(4), 886-898. [More Information]
  • Zengin, A., Nguyen, A., Wong, I., Zhang, L., Enriquez, R., Eisman, J., Herzog, H., Baldock, P., Salis, A. (2013). Neuropeptide Y mediates the short-term hypometabolic effect of estrogen deficiency in mice. International Journal of Obesity, 37(3), 390-398. [More Information]
  • Purtell, L., Jenkins, A., Viardot, A., Herzog, H., Salis, A., Smith, A., Loughnan, G., Steinbeck, K., Campbell, L., Sze, L. (2013). Postprandial cardiac autonomic function in Prader-Willi syndrome. Clinical Endocrinology, 79(1), 128-133. [More Information]
  • Shi, Y., Lin, Z., Lau, J., Zhang, H., Yagi, M., Kanzler, I., Salis, A., Herzog, H., Lin, S. (2013). PYY3-36 and pancreatic polypeptide reduce food intake in an additive manner via distinct hypothalamic dependent pathways in mice. Obesity, 21(12), E669-E678. [More Information]
  • Tsai, V., Macia, L., Johnen, H., Kuffner, T., Manadhar, R., Jorgensen, S., Lee-Ng, K., Zhang, H., Wu, L., Marquis, C., Salis, A., et al (2013). TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator. PLoS One, 8(2), e55174. [More Information]

2012

  • Shi, Y., Hammerle, C., Lee, I., Turner, N., Nguyen, A., Riepler, S., Lin, S., Salis, A., Herzog, H., Zhang, L. (2012). Adult-onset PYY overexpression in mice reduces food intake and increases lipogenic capacity. Neuropeptides, 46(4), 173-182. [More Information]
  • Tsai, V., Husaini, Y., Manandhar, R., Lee-Ng, K., Zhang, H., Harriott, K., Jiang, L., Lin, S., Salis, A., Brown, D., et al (2012). Anorexia/cachexia of chronic diseases: a role for the TGF-beta family cytokine MIC-1/GDF15. Journal of Cachexia, Sarcopenia and Muscle, 3(4), 239-243. [More Information]
  • Salis, A. (2012). Don't Go Hungry for Life. Sydney: Random House Australia.
  • Laurence, M., Tsai, V., Nguyen, A., Johnen, H., Kuffner, T., Shi, Y., Lin, S., Herzog, H., Brown, D., Breit, S., Salis, A. (2012). Macrophage Inhibitory Cytokine 1 (MIC-1/GDF15) Decreases Food Intake, Body Weight and Improves Glucose Tolerance in Mice on Normal & Obesogenic Diets. PLoS One, 7(4), 1-8. [More Information]
  • Breit, S., Carrero, J., Tsai, V., Yagoutifam, N., Luo, W., Kuffner, T., Bauskin, A., Wu, L., Jiang, L., Barany, P., Salis, A., et al (2012). Macrophage inhibitory cytokine-1 (MIC-1/GDF15) and mortality in end-stage renal disease. Nephrology, Dialysis, Transplantation, 27(1), 70-75. [More Information]
  • Sousa, D., Baldock, P., Enriquez, R., Zhang, L., Salis, A., Lamghari, M., Herzog, H. (2012). Neuropeptide Y Y1 receptor antagonism increases bone mass in mice. Bone, 51(1), 8-16. [More Information]
  • Macia, L., Yulyaningsih, E., Pangon, L., Nguyen, A., Lin, S., Shi, Y., Zhang, L., Bijker, M., Grey, S., Mackay, F., Salis, A., et al (2012). Neuropeptide Y1 Receptor in Immune Cells Regulates Inflammation and Insulin Resistance Associated With Diet-Induced Obesity. Diabetes, 61(12), 3228-3238. [More Information]
  • Zhang, L., Nguyen, A., Lee, I., Yulyaningsih, E., Riepler, S., Stehrer, B., Enriquez, R., Lin, S., Shi, Y., Baldock, P., Salis, A., et al (2012). NPY modulates PYY function in the regulation of energy balance and glucose homeostasis. Diabetes, Obesity and Metabolism, 14(8), 727-736. [More Information]
  • Lee, N., Nguyen, A., Enriquez, R., Doyle, K., Sainsbury, A., Baldock, P., Herzog, H. (2012). Osteoblast specific Y1 receptor deletion enhances bone mass. Bone, 48(3), 461-467. [More Information]
  • Wong, I., Driessler, F., Khor, E., Shi, Y., Hormer, B., Nguyen, A., Enriquez, R., Eisman, J., Salis, A., Herzog, H., et al (2012). Peptide YY Regulates Bone Remodeling in Mice: A Link between Gut and Skeletal Biology. PLoS One, 7(7), 1-12. [More Information]
  • Salis, A., Zhang, L. (2012). Role of the hypothalamus in the neuroendocrine regulation of body weight and composition during energy deficit. Obesity Reviews, 13(3), 234-257. [More Information]
  • Salis, A. (2012). The Biology of Weight Control. In Louise A. Baur, Stephen M. Twigg, Roger S.Magnusson (Eds.), A Modern Epidemic: Expert Perspectives on Obesity and Diabetes, (pp. 3-19). Sydney, Australia: Sydney University Press.
  • Baldock, P., Driessler, F., Lin, S., Wong, I., Shi, Y., Yulyaningsih, E., Castillo, L., Janmaat, S., Enriquez, R., Zengin, A., Salis, A., et al (2012). The endogenous opioid dynorphin is required for normal bone homeostasis in mice. Neuropeptides, 46(6), 383-394. [More Information]
  • Chesworth, R., Yulyaningsih, E., Cappas, E., Arnold, J., Salis, A., Karl, T. (2012). The response of neuregulin 1 mutant mice to acute restraint stress. Neuroscience Letters, 515(1), 82-86. [More Information]
  • Nguyen, A., Mitchell, N., Lin, S., Macia, L., Yulyaningsih, E., Baldock, P., Enriquez, R., Zhang, L., Shi, Y., Zolotukhin, S., Salis, A., et al (2012). Y1 and Y5 Receptors are Both Required for the Regulation of Food Intake and Energy Homeostasis in Mice. PLoS One, 7(6), 1-16. [More Information]

2011

  • Preston, E., Cooney, G., Wilks, D., Baran, K., Zhang, L., Kraegen, E., Salis, A. (2011). Central neuropeptide Y infusion and melanocortin 4 receptor antagonism inhibit thyrotropic function by divergent pathways. Neuropeptides, 45(6), 407-415. [More Information]
  • Sze, L., Purtell, L., Jenkins, A., Loughnan, G., Smith, E., Herzog, H., Salis, A., Steinbeck, K., Campbell, L., Viardot, A. (2011). Effects of a Single Dose of Exenatide on Appetite, Gut Hormones, and Glucose Homeostasis in Adults with Prader-Willi Syndrome. Journal of Clinical Endocrinology and Metabolism, 96(8), E1314-E1319. [More Information]
  • Purtell, L., Sze, L., Loughnan, G., Smith, E., Herzog, H., Sainsbury, A., Steinbeck, K., Campbell, L., Viardot, A. (2011). In adults with Prader-Willi syndrome, elevated ghrelin levels are more consistent with hyperphagia than high PYY and GLP-1 levels. Neuropeptides, 45(4), 301-307. [More Information]
  • Nguyen, A., Herzdog, H., Sainsbury, A. (2011). Neuropeptide Y and peptide YY: important regulators of energy metabolism. Current Opinion in Endocrinology, Diabetes, and Obesity, 18(1), 56-60. [More Information]
  • Yulyaningsih, E., Zhang, L., Herzog, H., Salis, A. (2011). NPY receptors as potential targets for anti-obesity drug development. British Journal of Pharmacology, 163(6), 1170-1202. [More Information]
  • Shi, Y., Lin, S., Castillo, L., Aljanova, A., Enriquez, R., Baldock, P., Nguyen, A., Zhang, L., Bijker, M., Macia, L., Salis, A., et al (2011). Peripheral-Specific Y2 Receptor Knockdown Protects Mice From High-Fat Diet-Induced Obesity. Obesity, 19(11), 2137-7148. [More Information]
  • Lau, S., Lin, S., Stokes, R., Cheng, K., Baldock, P., Enriquez, R., Mclean, M., Cheung, N., Sainsbury, A., Gonzalez, F., Gunton, J., et al (2011). Synergistic effects of genetic beta cell dysfunction and maternal glucose intolerance on offspring metabolic phenotype in mice. Diabetologia: clinical and experimental diabetes and metabolism, 54(4), 910-921. [More Information]
  • Lee, N., Allison, S., Enriquez, R., Sainsbury, A., Herzog, H., Baldock, P. (2011). Y2 and Y4 receptor signalling attenuates the skeletal response of central NPY. Journal of Molecular Neuroscience, 43(2), 123-131. [More Information]
  • Lin, E., Zhang, L., Sainsbury, A., Herzog, H. (2011). Y2, Y4 receptors and obesity. Expert Review of Endocrinology and Metabolism, 2, 2. [More Information]

2010

  • Zhou, Y., Lee, N., Nguyen, A., Enriquez, R., Riepler, S., Stehrer, B., Zanchetta, J., Baldock, P., Herzog, H., Salis, A., et al (2010). Additive actions of the cannabinoid and neuropeptide Y systems on adiposity and lipid oxidation. Diabetes, Obesity and Metabolism, 12(7), 591-603. [More Information]
  • Lee, N., Doyle, K., Salis, A., Enriquez, R., Hort, Y., Riepler, S., Baldock, P., Herzog, H. (2010). Critical role for Y1 receptors in mesenchymal progenitor cell differentiation and osteoblast activity. Journal of Bone and Mineral Research, 25, 1736-1747. [More Information]
  • Zengin, A., Zhang, L., Herzog, H., Baldock, P., Salis, A. (2010). Neuropeptide Y and sex hormone interactions in humoral and neuronal regulation of bone and fat. Trends in Endocrinology and Metabolism, 21, 411-418. [More Information]
  • Shi, Y., Lin, S., Wong, I., Baldock, P., Aljanova, A., Enriquez, R., Castillo, L., Mitchell, N., Ye, J., Zhang, L., Salis, A., et al (2010). NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not Cortical Bone Homeostasis in Mice. PLoS One, 5(6), 1-16. [More Information]
  • Cox, H., Tough, I., Woolston, A., Zhang, L., Nguyen, A., Salis, A., Herzog, H. (2010). Peptide YY is critical for acylethanolamine receptor Gpr119-induced activation of gastrointestinal mucosal responses. Cell Metabolism, 11, 532-542. [More Information]
  • Viardot, A., Sze, L., Purtell, L., Sainsbury, A., Loughnan, G., Smith, E., Herzog, H., Steinbeck, K., Campbell, L. (2010). Prader-Willi Syndrome Is Associated with Activation of the Innate Immune System Independently of Central Adiposity and Insulin Resistance. Journal of Clinical Endocrinology and Metabolism, 95(7), 3392-3399. [More Information]
  • Zhang, L., Riepler, S., Turner, N., Enriquez, R., Lee, I., Baldock, P., Herzog, H., Salis, A. (2010). Y2 and Y4 receptor signaling synergistically act on energy expenditure and physical activity. American Journal of Physiology, 299, R1618-R1628. [More Information]
  • Salis, A., Shi, Y., Zhang, L., Aljanova, A., Lin, Z., Nguyen, A., Herzog, H., Lin, S. (2010). Y4 receptors and pancreatic polypeptide regulate food intake via hypothalamic orexin and brain-derived neurotropic factor dependent pathways. Neuropeptides, 44, 261-268. [More Information]

2009

  • Allison, S., Baldock, P., Enriquez, R., Lin, E., During, M., Gardiner, E., Eisman, J., Salis, A., Herzog, H. (2009). Critical interplay between neuropeptide Y and sex steroid pathways in bone and adipose tissue homeostasis. Journal of Bone and Mineral Research, 24(2), 294-304. [More Information]
  • Lin, S., Shi, Y., Yulyaningsih, E., Aljanova, A., Zhang, L., Macia, L., Nguyen, A., Lin, E., During, M., Herzog, H., Salis, A. (2009). Critical role of arcuate y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice. PLoS One, 4(12), e8488-e8488. [More Information]
  • Salis, A., Zhang, L. (2009). Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit. Molecular And Cellular Endocrinology, 316, 109-119. [More Information]
  • Lovejoy, J., Salis, A. (2009). Sex differences in obesity and the regulation of energy homeostasis. Obesity Reviews, 10, 154-167. [More Information]

2008

  • Boey, D., Lin, S., Enriquez, R., Lee, N., Slack, K., Couzens, M., Baldock, P., Herzog, H., Salis, A. (2008). PYY transgenic mice are protected against diet-induced and genetic obesity. Neuropeptides, 42(1), 19-30. [More Information]
  • Lee, N., Enriquez, R., Boey, D., Lin, S., Slack, K., Baldock, P., Herzog, H., Salis, A. (2008). Synergistic attenuation of obesity by Y2- and Y4-receptor double knockout in ob/ob mice. Nutrition, 24, 892-899. [More Information]

2007

  • Salis, A., Lin, S., McNamara, K., Slack, K., Enriquez, R., Lee, N., Boey, D., Smythe, G., Schwarzer, C., Baldock, P., et al (2007). Dynorphin knockout reduces fat mass and increases weight loss during fasting in mice. Molecular Endocrinology, 21(7), 1722-1735. [More Information]
  • Lin, S., Lin, E., Boey, D., Lee, N., Slack, K., During, M., Salis, A., Herzog, H. (2007). Fasting inhibits the growth and reproductive axes via distinct Y2 and Y4 receptor-mediated pathways. Endocrinology, 148(5), 2056-2065. [More Information]
  • Lundberg, P., Allison, S., Lee, N., Baldock, P., Brouard, N., Rost, S., Enriquez, R., Salis, A., Lamghari, M., Simmons, P., et al (2007). Greater bone formation of Y2 knockout mice is associated with increased osteoprogenitor numbers and altered Y1 receptor expression. Journal of Biological Chemistry, 282(26), 19082-19091. [More Information]
  • Baldock, P., Allison, S., Lundberg, P., Lee, N., Slack, K., Lin, E., Enriquez, R., McDonald, M., Zhang, L., During, M., Little, D., et al (2007). Novel role of y1 receptors in the coordinated regulation of bone and energy homeostasis. Journal of Biological Chemistry, 282(26), 19092-19102. [More Information]
  • Salis, A. (2007). The Don’t Go Hungry Diet. Australia: Bantam Australia.
  • Boey, D., Salis, A., Herzog, H. (2007). The role of peptide YY in regulating glucose homeostasis. Peptides, 28(2), 390-395. [More Information]
  • Johnen, H., Lin, S., Kuffner, T., Brown, D., Tsai, V., Bauskin, A., Wu, L., Pankhurst, G., Jiang, L., Junankar, S., Salis, A., et al (2007). Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nature Medicine, 13(11), 1333-1340. [More Information]

2006

  • Lin, E., Lee, N., Slack, K., Karl, T., Duffy, L., O'Brien, E., Matsumoto, I., Dedova, I., Herzog, H., Sainsbury, A. (2006). Distinct endocrine effects of chronic haloperidol or risperidone administration in male rats. Neuropharmacology, 51(7-8), 1129-1136. [More Information]
  • Baldock, P., Allison, S., McDonald, M., Sainsbury, A., Enriquez, R., Little, D., Eisman, J., Gardiner, E., Herzog, H. (2006). Hypothalamic regulation of cortical bone mass: opposing activity of Y2 receptor and leptin pathways. Journal of Bone and Mineral Research, 21(10), 1600-1607. [More Information]

2005

  • Wheway, J., Mackay, C., Newton, R., Sainsbury, A., Boey, D., Herzog, H., Mackay, F. (2005). A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. The Journal of Experimental Medicine, 202(11), 1527-1538. [More Information]

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