Dr Anna Waterhouse

ARC Discovery Early Career Researcher
Heart Research Institute

Member of The University of Sydney Nano Institute

Member of the Charles Perkins Centre


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Biographical details

Dr Waterhouse is the recipient of an ARC DECRA based at the Charles Perkins Centre at the University of Sydney in the Central Clinical School, Sydney Medical School. Dr Waterhouse is also a Group Leader of the Cardiovascular Medical Devices Group at the Heart Research Institute.

She obtained her PhD from the University of Sydney and BSc (hons) from the University of Manchester, UK. Prior to her appointment here in 2016, Dr Waterhouse was a Postdoctoral Fellow and then Research Scientist at the Wyss Institute for Biologically Inspired Engineering at Harvard University.

Research interests

Blood contacting medical devices are used widely for a range of treatments; for example, catheters for administration of drugs, artificial hearts, vascular stents, vascular grafts, heart valves, hemodialysis circuits, cardiopulmonary bypass circuits, and extracorporeal membrane oxygenator circuits. Thrombosis is the most frequent cause of medical device failure, resulting in increased medical costs and high rates of patient morbidity and mortality. For example, thrombosis accounts for 50% of ventricular assist device removals and caused death in 30% of those cases. Thrombosis of medical devices is currently managed with medication that causes additional complications, such as bleeding from antiplatelet or anticoagulant drugs. Indeed, systemic anticoagulation causes the majority of drug-related deaths from adverse clinical events. In order to reduce medical device failure, excessive use of anticoagulants and associated economic and human costs, it is essential to gain a complete understanding of how medical device thrombosis occurs. Furthermore, many medical devices suffer from microbial biofouling from bacteria and fungi growth. Biofouling is treated with antibiotics, however, antibiotics can’t always penetrate the biofilm and the overuse of antibiotics is leading to antibiotic resistant pathogens.

Our goal is to understand the interactions of medical devices with patients’ blood, proteins and cells to develop more sophisticated and compatible materials for medical devices for the diagnosis and treatment of cardiovascular disease. To achieve these goals, our team applies cutting edge bioengineering tools to develop new methodologies to assess and understand the interplay of events at the biointerface. Combining physical, chemical and biological surface modification methods, medical devices can be manipulated to interact with, repel or adhere proteins or cells to improve medical device function, create novel diagnostics and medical devices and both drug and non-drug based avenues for therapies.

Current projects

Biointerfaces

Understanding the interactions of medical devices with patients’ blood, proteins and cells will allow the development of more sophisticated and compatible materials for medical devices for the diagnosis and treatment of cardiovascular disease. To achieve these goals we utilise cutting edge bioengineering tools to develop new methodologies to assess and understand the interplay of events at the biointerface. This includes immobilising proteins or creating anti-adhesive coatings and investigating the biological response at the interface of the materials using advanced microscopy and surface analysis tools.

Biomimetic model systems

Advances in material fabrication techniques and 3D printing in micro and nanotechnology have revolutionised bioengineering, allowing high precision manipulation of materials for modelling medical systems and devices in the lab. Using these strategies, biomimetic in vitro model systems can be generated to recreate physiological conditions to evaluate medical device materials, geometries and drugs. Device failure mechanisms and how different disease states contribute to them can be investigated with the aim of developing new treatments or preventions.

Bioengineering smart materials

Medical device thrombosis and biofouling leading to sepsis cause significant morbidity and mortality worldwide. Furthermore, there is an urgent need to reduce the complications that arise from drugs designed to combat these issues, such as anticoagulants that cause bleeding and the overuse of antibiotics that result in antibiotic resistant pathogens. Using bioengineering strategies, increasingly sophisticated materials can be constructed. Combining physical, chemical and biological surface modification methods, medical devices can be manipulated to interact with, repel or adhere proteins or cells to improve medical device function, create novel diagnostics and medical devices and both drug and non-drug based avenues for therapies.

Associations

Member of the University of Sydney Nano Institute

Visiting Scholar, Wyss Institute for Biologically Inspired Engineering

Selected grants

2018

  • Slippery surface coatings to prevent medical device blood clots; Waterhouse A; DVC Research/Laffan Fellowships.

2016

  • An in vitro model of biomaterial-induced thrombosis; Waterhouse A; Australian Research Council (ARC)/Discovery Early Career Researcher Award (DECRA).

Selected publications

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Journals

  • Leslie, D., Waterhouse, A., Ingber, D. (2017). New anticoagulant coatings and hemostasis assessment tools to avoid complications with pediatric left ventricular assist devices. Journal of Thoracic and Cardiovascular Surgery, 154(4), 1364-1366. [More Information]
  • Cartwright, M., Rottman, M., Shapiro, N., Seiler, B., Lombardo, P., Gamini, N., Tomolonis, J., Watters, A., Waterhouse, A., Leslie, D., et al (2016). A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood. EBioMedicine, 9, 217-227. [More Information]
  • Jain, A., Graveline, A., Waterhouse, A., Vernet, A., Flaumenhaft, R., Ingber, D. (2016). A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function. Nature Communications, 7, 1-10. [More Information]
  • Sotiri, I., Overton, J., Waterhouse, A., Howell, C. (2016). Immobilized liquid layers: A new approach to anti-adhesion surfaces for medical applications. Experimental Biology and Medicine, 241(9), 909-918. [More Information]
  • Wise, S., Michael, P., Waterhouse, A., Santos, M., Filipe, E., Hung, J., Kondyurin, A., Bilek, M., Ng, M. (2015). Immobilization of bioactive plasmin reduces the thrombogenicity of metal surfaces. Colloids And Surfaces B: Biointerfaces, 136, 944-954. [More Information]
  • Didar, T., Cartwright, M., Rottman, M., Graveline, A., Gamini, N., Watters, A., Leslie, D., Mammoto, T., Rodas, M., Waterhouse, A., et al (2015). Improved treatment of systemic blood infections using antibiotics with extracorporeal opsonin hemoadsorption. Biomaterials, 67, 382-392. [More Information]
  • Howell, C., Vu, T., Johnson, C., Huo, X., Ahanotu, O., Alvarenga, J., Leslie, D., Uzun, O., Waterhouse, A., Kim, P., et al (2015). Stability of Surface-Immobilized Lubricant Interfaces under Flow. Chemistry of Materials, 27(5), 1792-1800. [More Information]
  • Leslie, D., Waterhouse, A., Berthat, J., Valentin, T., Watters, A., Jain, A., Kim, P., Hatton, B., Nedder, A., Donovan, K., et al (2014). A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling. Nature Biotechnology, 32(11), 1134-1140. [More Information]
  • Kang, J., Super, M., Yung, C., Cooper, R., Domansky, K., Graveline, A., Mammoto, T., Berthat, J., Tobin, H., Waterhouse, A., et al (2014). An extracorporeal blood-cleansing device for sepsis therapy. Nature Medicine, 20(10), 1211-1216. [More Information]
  • Hajian, H., Wise, S., Bax, D., Kondyurin, A., Waterhouse, A., Dunn, L., Kielty, C., Yu, Y., Weiss, A., Bilek, M., Bannon, P., et al (2014). Immobilisation of a fibrillin-1 fragment enhances the biocompatibility of PTFE. Colloids And Surfaces B: Biointerfaces, 116, 544-552. [More Information]
  • Bax, D., Kondyurin, A., Waterhouse, A., McKenzie, D., Weiss, A., Bilek, M. (2014). Surface plasma modification and tropoelastin coating of a polyurethane co-polymer for enhanced cell attachment and reduced thrombogenicity. Biomaterials, 35(25), 6797-6809. [More Information]
  • Zhou, X., Smith, A., Waterhouse, A., Blin, G., Malaguti, M., Lin, C., Osorno, R., Chambers, I., Lowell, S. (2013). Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity. Stem Cells, 31(8), 1511-1522. [More Information]
  • Hirsh, S., Bilek, M., Bax, D., Kondyurin, A., Kosobrodova, E., Tsoutas, K., Tran, C., Waterhouse, A., Yin, Y., Nosworthy, N., McKenzie, D., Dos Remedios, C., Weiss, A., et al (2013). Ion Implanted, Radical-Rich Surfaces For The Rapid Covalent Immobilization Of Active Biomolecules. AIP Conference Proceedings, 1525, 364-369. [More Information]
  • Davies, O., Lin, C., Radzisheuskaya, A., Zhou, X., Taube, J., Blin, G., Waterhouse, A., Smith, A., Lowell, S. (2013). Tcf15 primes pluripotent cells for differentiation. Cell Reports, 3(2), 472-484. [More Information]
  • Hiob, M., Wise, S., Kondyurin, A., Waterhouse, A., Bilek, M., Ng, M., Weiss, A. (2013). The use of plasma-activated covalent attachment of early domains of tropoelastin to enhance vascular compatibility of surfaces. Biomaterials, 34(31), 7584-7591. [More Information]
  • Wise, S., Waterhouse, A., Michael, P., Ng, M. (2012). Extracellular matrix molecules facilitating vascular biointegration. Journal of Functional Biomaterials, 3(3), 569-587. [More Information]
  • Waterhouse, A., Wise, S., Yin, Y., Wu, B., James, B., Zreiqat, H., McKenzie, D., Bao, B., Weiss, A., Ng, M., Bilek, M. (2012). In vivo biocompatibility of a plasma-activated, coronary stent coating. Biomaterials, 33(32), 7984-7992. [More Information]
  • Wise, S., Waterhouse, A., Kondyurin, A., Bilek, M., Weiss, A. (2012). Plasma-based biofunctionalization of vascular implants. Nanomedicine, 7(12), 1907-1916. [More Information]
  • Wise, S., Byrom, M., Waterhouse, A., Bannon, P., Ng, M., Weiss, A. (2011). A multilayered synthetic human elastin/polycaprolactone hybrid vascular graft with tailored mechanical properties. Acta Biomaterialia, 7(1), 295-303. [More Information]
  • Waterhouse, A., Wise, S., Ng, M., Weiss, A. (2011). Elastin as a Nonthrombogenic Biomaterial. Tissue Engineering. Part B. Reviews, 17(2), 93-99. [More Information]
  • Bilek, M., Bax, D., Kondyurin, A., Yin, Y., Nosworthy, N., Fisher, K., Waterhouse, A., Weiss, A., Dos Remedios, C., McKenzie, D. (2011). Free radical functionalization of surfaces to prevent adverse responses to biomedical devices. Proceedings of the National Academy of Sciences of the United States of America, 108(35), 14405-14410. [More Information]
  • Waterhouse, A., Bax, D., Wise, S., Yin, Y., Dunn, L., Yeo, G., Ng, M., Bilek, M., Weiss, A. (2011). Stability of a Therapeutic Layer of Immobilized Recombinant Human Tropoelastin on a Plasma-Activated Coated Surface. Pharmaceutical Research, 28(6), 1415-1421. [More Information]
  • Almine, J., Bax, D., Mithieux, S., Nivison-Smith, L., Rnjak-Kovacina, J., Waterhouse, A., Wise, S., Weiss, A. (2010). Elastin-based materials. Chemical Society Reviews, 39(9), 3371-3379. [More Information]
  • Waterhouse, A., Bax, D., Wise, S., Yin, Y., Dunn, L., Yeo, G., Ng, M., Bilek, M., Weiss, A. (2010). Stability of a Therapeutic Layer of Immobilized Recombinant Human Tropoelastin on a Plasma-Activated Coated Surface. Pharmaceutical Research, , 1-7. [More Information]
  • Waterhouse, A., Yin, Y., Wise, S., Bax, D., McKenzie, D., Bilek, M., Weiss, A., Ng, M. (2010). The immobilization of recombinant human tropoelastin on metals using a plasma-activated coating to improve the biocompatibility of coronary stents. Biomaterials, 31(32), 8332-8340. [More Information]
  • Yin, Y., Wise, S., Nosworthy, N., Waterhouse, A., Bax, D., Youssef, H., Byrom, M., Bilek, M., McKenzie, D., Weiss, A., Ng, M. (2009). Covalent immobilisation of tropoelastin on a plasma deposited interface for enhancement of endothelialisation on metal surfaces. Biomaterials, 30(9), 1675-1681. [More Information]
  • Waterhouse, A., Wise, S., Yin, Y., Bilek, M., Weiss, A., Ng, M. (2009). Plasma-mediated immobilisation of recombinant tropoelastin dramatically enhances vascular biocompatibility of metals: Implications for coronary stents. Heart, Lung and Circulation, 18(3), S224-S224.

2017

  • Leslie, D., Waterhouse, A., Ingber, D. (2017). New anticoagulant coatings and hemostasis assessment tools to avoid complications with pediatric left ventricular assist devices. Journal of Thoracic and Cardiovascular Surgery, 154(4), 1364-1366. [More Information]

2016

  • Cartwright, M., Rottman, M., Shapiro, N., Seiler, B., Lombardo, P., Gamini, N., Tomolonis, J., Watters, A., Waterhouse, A., Leslie, D., et al (2016). A Broad-Spectrum Infection Diagnostic that Detects Pathogen-Associated Molecular Patterns (PAMPs) in Whole Blood. EBioMedicine, 9, 217-227. [More Information]
  • Jain, A., Graveline, A., Waterhouse, A., Vernet, A., Flaumenhaft, R., Ingber, D. (2016). A shear gradient-activated microfluidic device for automated monitoring of whole blood haemostasis and platelet function. Nature Communications, 7, 1-10. [More Information]
  • Sotiri, I., Overton, J., Waterhouse, A., Howell, C. (2016). Immobilized liquid layers: A new approach to anti-adhesion surfaces for medical applications. Experimental Biology and Medicine, 241(9), 909-918. [More Information]

2015

  • Wise, S., Michael, P., Waterhouse, A., Santos, M., Filipe, E., Hung, J., Kondyurin, A., Bilek, M., Ng, M. (2015). Immobilization of bioactive plasmin reduces the thrombogenicity of metal surfaces. Colloids And Surfaces B: Biointerfaces, 136, 944-954. [More Information]
  • Didar, T., Cartwright, M., Rottman, M., Graveline, A., Gamini, N., Watters, A., Leslie, D., Mammoto, T., Rodas, M., Waterhouse, A., et al (2015). Improved treatment of systemic blood infections using antibiotics with extracorporeal opsonin hemoadsorption. Biomaterials, 67, 382-392. [More Information]
  • Howell, C., Vu, T., Johnson, C., Huo, X., Ahanotu, O., Alvarenga, J., Leslie, D., Uzun, O., Waterhouse, A., Kim, P., et al (2015). Stability of Surface-Immobilized Lubricant Interfaces under Flow. Chemistry of Materials, 27(5), 1792-1800. [More Information]

2014

  • Leslie, D., Waterhouse, A., Berthat, J., Valentin, T., Watters, A., Jain, A., Kim, P., Hatton, B., Nedder, A., Donovan, K., et al (2014). A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling. Nature Biotechnology, 32(11), 1134-1140. [More Information]
  • Kang, J., Super, M., Yung, C., Cooper, R., Domansky, K., Graveline, A., Mammoto, T., Berthat, J., Tobin, H., Waterhouse, A., et al (2014). An extracorporeal blood-cleansing device for sepsis therapy. Nature Medicine, 20(10), 1211-1216. [More Information]
  • Hajian, H., Wise, S., Bax, D., Kondyurin, A., Waterhouse, A., Dunn, L., Kielty, C., Yu, Y., Weiss, A., Bilek, M., Bannon, P., et al (2014). Immobilisation of a fibrillin-1 fragment enhances the biocompatibility of PTFE. Colloids And Surfaces B: Biointerfaces, 116, 544-552. [More Information]
  • Bax, D., Kondyurin, A., Waterhouse, A., McKenzie, D., Weiss, A., Bilek, M. (2014). Surface plasma modification and tropoelastin coating of a polyurethane co-polymer for enhanced cell attachment and reduced thrombogenicity. Biomaterials, 35(25), 6797-6809. [More Information]

2013

  • Zhou, X., Smith, A., Waterhouse, A., Blin, G., Malaguti, M., Lin, C., Osorno, R., Chambers, I., Lowell, S. (2013). Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity. Stem Cells, 31(8), 1511-1522. [More Information]
  • Hirsh, S., Bilek, M., Bax, D., Kondyurin, A., Kosobrodova, E., Tsoutas, K., Tran, C., Waterhouse, A., Yin, Y., Nosworthy, N., McKenzie, D., Dos Remedios, C., Weiss, A., et al (2013). Ion Implanted, Radical-Rich Surfaces For The Rapid Covalent Immobilization Of Active Biomolecules. AIP Conference Proceedings, 1525, 364-369. [More Information]
  • Davies, O., Lin, C., Radzisheuskaya, A., Zhou, X., Taube, J., Blin, G., Waterhouse, A., Smith, A., Lowell, S. (2013). Tcf15 primes pluripotent cells for differentiation. Cell Reports, 3(2), 472-484. [More Information]
  • Hiob, M., Wise, S., Kondyurin, A., Waterhouse, A., Bilek, M., Ng, M., Weiss, A. (2013). The use of plasma-activated covalent attachment of early domains of tropoelastin to enhance vascular compatibility of surfaces. Biomaterials, 34(31), 7584-7591. [More Information]

2012

  • Wise, S., Waterhouse, A., Michael, P., Ng, M. (2012). Extracellular matrix molecules facilitating vascular biointegration. Journal of Functional Biomaterials, 3(3), 569-587. [More Information]
  • Waterhouse, A., Wise, S., Yin, Y., Wu, B., James, B., Zreiqat, H., McKenzie, D., Bao, B., Weiss, A., Ng, M., Bilek, M. (2012). In vivo biocompatibility of a plasma-activated, coronary stent coating. Biomaterials, 33(32), 7984-7992. [More Information]
  • Wise, S., Waterhouse, A., Kondyurin, A., Bilek, M., Weiss, A. (2012). Plasma-based biofunctionalization of vascular implants. Nanomedicine, 7(12), 1907-1916. [More Information]

2011

  • Wise, S., Byrom, M., Waterhouse, A., Bannon, P., Ng, M., Weiss, A. (2011). A multilayered synthetic human elastin/polycaprolactone hybrid vascular graft with tailored mechanical properties. Acta Biomaterialia, 7(1), 295-303. [More Information]
  • Waterhouse, A., Wise, S., Ng, M., Weiss, A. (2011). Elastin as a Nonthrombogenic Biomaterial. Tissue Engineering. Part B. Reviews, 17(2), 93-99. [More Information]
  • Bilek, M., Bax, D., Kondyurin, A., Yin, Y., Nosworthy, N., Fisher, K., Waterhouse, A., Weiss, A., Dos Remedios, C., McKenzie, D. (2011). Free radical functionalization of surfaces to prevent adverse responses to biomedical devices. Proceedings of the National Academy of Sciences of the United States of America, 108(35), 14405-14410. [More Information]
  • Waterhouse, A., Bax, D., Wise, S., Yin, Y., Dunn, L., Yeo, G., Ng, M., Bilek, M., Weiss, A. (2011). Stability of a Therapeutic Layer of Immobilized Recombinant Human Tropoelastin on a Plasma-Activated Coated Surface. Pharmaceutical Research, 28(6), 1415-1421. [More Information]

2010

  • Almine, J., Bax, D., Mithieux, S., Nivison-Smith, L., Rnjak-Kovacina, J., Waterhouse, A., Wise, S., Weiss, A. (2010). Elastin-based materials. Chemical Society Reviews, 39(9), 3371-3379. [More Information]
  • Waterhouse, A., Bax, D., Wise, S., Yin, Y., Dunn, L., Yeo, G., Ng, M., Bilek, M., Weiss, A. (2010). Stability of a Therapeutic Layer of Immobilized Recombinant Human Tropoelastin on a Plasma-Activated Coated Surface. Pharmaceutical Research, , 1-7. [More Information]
  • Waterhouse, A., Yin, Y., Wise, S., Bax, D., McKenzie, D., Bilek, M., Weiss, A., Ng, M. (2010). The immobilization of recombinant human tropoelastin on metals using a plasma-activated coating to improve the biocompatibility of coronary stents. Biomaterials, 31(32), 8332-8340. [More Information]

2009

  • Yin, Y., Wise, S., Nosworthy, N., Waterhouse, A., Bax, D., Youssef, H., Byrom, M., Bilek, M., McKenzie, D., Weiss, A., Ng, M. (2009). Covalent immobilisation of tropoelastin on a plasma deposited interface for enhancement of endothelialisation on metal surfaces. Biomaterials, 30(9), 1675-1681. [More Information]
  • Waterhouse, A., Wise, S., Yin, Y., Bilek, M., Weiss, A., Ng, M. (2009). Plasma-mediated immobilisation of recombinant tropoelastin dramatically enhances vascular biocompatibility of metals: Implications for coronary stents. Heart, Lung and Circulation, 18(3), S224-S224.

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