Professor Chris Jackson
Medicine, Northern Clinical School
Kolling Institute of Medical Research
Career summary
Dr Jackson’s research team is directly involved with several departments at Royal North Shore Hospital including Rheumatology, the Severe Burns Unit, Dermatology, Endocrinology and the Institute of Bone and Joint Research at the University of Sydney. Dr Jackson works closely with the clinicians and co-supervises PhD students from those departments. These strong links ensure that human specimens are readily available for his research. Additionally, they ensure that his research is patient-orientated with the ultimate aim of solving health issues related to arthritis, particularly rheumatoid arthritis, and inflammatory skin conditions.
The strategies used for Dr Jackson’s research has allowed it to become true bench to bedside translational research. After making the original discovery that activated protein C (APC) heals wounds, Dr Jackson was given the opportunity to develop the concept with an NHMRC Development Grant (#25388, Activated protein C to promote wound healing, 2003-5). Together with Dr Meilang Xue, he undertook extensive basic laboratory studies, including pre-clinical animal studies to obtain proof-of-concept. With help from his clinical colleagues at RNSH, he progressed the work to pilot human clinical trials in diabetic chronic wounds. With clinical collaborations firmly established and positive results from pilot studies showing that APC has strong potential to heal human chronic wounds, A randomised double-blind controlled clinical trial will shortly begin to test the efficacy of an APC variant to treat diabetic chronic leg ulcers, funded by NHMRC 1032549 grant and commercial sponsorship.
(to be declared) Prof David Hart is collaborating with us on the use of animal models for wound healing | |
(Hong Kong Polytehnic, Prof Tony To) collaborative project on photoporphyrins and cancer | |
(Department of Immunology, Saga Medical School, Nabeshima, Saga, Japan) Prof Fukudome provides essential tools and advice for our research on wound healing, arthritis and diabetes. | |
(College of Veterinary Medicine, Chonbuk National University, Jeonju) awarded a Korean Government grant and share 5 publications | |
(Scripps, Prof John Griffin and Prof Charles Fisher) provision of unique therapeutic agent for collaborative project |
Publications
Book Chapters
- Jackson, C., Xue, M. (2011). Anti-Inflammatory Actions of the Anticoagulant, Activated Protein C. In Amit Nagal (Eds.), Inflammatory Diseases - A Modern Perspective, (pp. 45-72). Rijeka: InTech Publishers. [More Information]
- Jackson, C., Schrieber, L. (2003). Angiogenesis in rheumatoid arthritis. In M C Hochberg, A J Silman, J S Smolen, M E Weinblatt, M H Weisman (Eds.), Rheumatology: Third Edition, (pp. 851-854). Edinburgh: Mosby.
Journals
- Xue, M., Lin, H., Zhao, R., Fryer, C., March, L., Jackson, C. (2022). Activated Protein C Protects against Murine Contact Dermatitis by Suppressing Protease-Activated Receptor 2. International Journal of Molecular Sciences, 23(1), 516. [More Information]
- Xue, M., Zhao, R., March, L., Jackson, C. (2022). Dermal Fibroblast Heterogeneity and Its Contribution to the Skin Repair and Regeneration. Advances in Wound Care, 11(2), 87-107. [More Information]
- Zhao, R., Lang, T., Kim, A., Wijewardena, A., Vandervord, J., McGrath, R., Fulcher, G., Xue, M., Jackson, C. (2022). Early protein C activation is reflective of burn injury severity and plays a critical role in inflammatory burden and patient outcomes. Burns, 48(1), 91-103. [More Information]
Conferences
- Little, C., Jackson, M., Smith, M., Burkhardt, D., Xue, M., Jackson, C. (2006). Potential role of activated protein C (APC) in articular cartilage degeneration. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Patents
- Jackson, C., Xue, M. (2021). An agent that prevents/treats the abnormal cutaneous scaring. Patent No. 2014391082, 2014391082, 3137102, 6846063, ZL201480078924.1, 3137102, ZL201480078924.1. , , China, China.
- Xue, M., Jackson, C. (2021). An agent that treats skin ulcers. Patent No. 2015246656, 2015246656, 3131552, 6873387, ZL201580025422.7, 6873387, ZL201580025422.7. , , China, China.
- Jackson, C., Xue, M. (2020). Treatment for Inflammatory Skin Diseases. Patent No. 10-2068010, 2013286812, 2662564, 2869833, 6273272, HK1204573, ZL201380034024.2, 2013286812, 2662564, 2869833, 6273272, HK1204573, ZL201380034024.2. , , Belgium, China, France, Germany, Hong Kong, Ireland, Italy, Korea (South), Netherlands, Russian Federation, Spain, Switzerland, United Kingdom, Belgium, China, France, Germany, Hong Kong, Ireland, Italy, Netherlands, Russian Federation, Spain, Switzerland, United Kingdom.
2022
- Xue, M., Lin, H., Zhao, R., Fryer, C., March, L., Jackson, C. (2022). Activated Protein C Protects against Murine Contact Dermatitis by Suppressing Protease-Activated Receptor 2. International Journal of Molecular Sciences, 23(1), 516. [More Information]
- Xue, M., Zhao, R., March, L., Jackson, C. (2022). Dermal Fibroblast Heterogeneity and Its Contribution to the Skin Repair and Regeneration. Advances in Wound Care, 11(2), 87-107. [More Information]
- Zhao, R., Lang, T., Kim, A., Wijewardena, A., Vandervord, J., McGrath, R., Fulcher, G., Xue, M., Jackson, C. (2022). Early protein C activation is reflective of burn injury severity and plays a critical role in inflammatory burden and patient outcomes. Burns, 48(1), 91-103. [More Information]
2021
- Beserra, F., Gushiken, L., Hussni, M., Ribeiro, V., Bonamin, F., Jackson, C., Pellizzon, C., Bastos, J. (2021). Artepillin C as an outstanding phenolic compound of Brazilian green propolis for disease treatment: A review on pharmacological aspects. Phytotherapy Research, 35(5), 2274-2286. [More Information]
- Gushiken, L., Beserra, F., Bastos, J., Jackson, C., Pellizzon, C. (2021). Cutaneous wound healing: An update from physiopathology to current therapies. Life, 11(7), 665-1-665-15. [More Information]
- Xue, M., Lin, H., Liang, H., McKelvey, K., Zhao, R., March, L., Jackson, C. (2021). Deficiency of protease-activated receptor (PAR) 1 and PAR2 exacerbates collagen-induced arthritis in mice via differing mechanisms. Rheumatology, 60(6), 2990-3003. [More Information]
2020
- Roche, C., Brereton, R., Ashton, A., Jackson, C., Gentile, C. (2020). Current challenges in three-dimensional bioprinting heart tissues for cardiac surgery. European Journal Of Cardio-Thoracic Surgery, 58(3), 500-510. [More Information]
- Beserra, F., Gushiken, L., Vieira, A., Bérgamo, D., Bérgamo, P., de Souza, M., Hussni, C., Takahira, R., Nóbrega, R., Martinez, E., Jackson, C., et al (2020). From inflammation to cutaneous repair: Topical application of lupeol improves skin wound healing in rats by modulating the cytokine levels, NF-κB, Ki-67, growth factor expression, and distribution of collagen fibers. International Journal of Molecular Sciences, 21(14), 1-22. [More Information]
- Charlton, O., Harris, V., Phan, K., Mewton, E., Jackson, C., Cooper, A. (2020). Toxic Epidermal Necrolysis and Steven-Johnson Syndrome: A Comprehensive Review. Advances in Wound Care, 9(7), 426-439. [More Information]
2019
- Lang, T., Zhao, R., Kim, A., Wijewardena, A., Vandervord, J., Xue, M., Jackson, C. (2019). A Critical Update of the Assessment and Acute Management of Patients with Severe Burns. Advances in Wound Care, 8(12), 607-633. [More Information]
- Zhao, R., Lin, H., Bereza-Malcolm, L., Clarke, E., Jackson, C., Xue, M. (2019). Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside. International Journal of Molecular Sciences, 20(4), 1-20. [More Information]
- Xue, M., Dervish, S., McKelvey, K., March, L., Wang, F., Little, C., Jackson, C. (2019). Activated protein C targets immune cells and rheumatoid synovial fibroblasts to prevent inflammatory arthritis in mice. Rheumatology, 58(10), 1850-1860. [More Information]
2018
- Xue, M., Zhao, R., Lin, H., Jackson, C. (2018). Delivery systems of current biologicals for the treatment of chronic cutaneous wounds and severe burns. Advanced Drug Delivery Reviews, 129, 219-241. [More Information]
- Xue, M., Jackson, C., Dervish, S. (2018). Isolation of Human Skin Epidermal Stem Cells Based on the Expression of Endothelial Protein C Receptor. Methods in Molecular Biology, 1879, 165-174. [More Information]
- Beserra, F., Xue, M., Maia, G., Rozza, A., Pellizzon, C., Jackson, C. (2018). Lupeol, a Pentacyclic Triterpene, Promotes Migration, Wound Closure, and Contractile Effect In Vitro: Possible Involvement of PI3K/Akt and p38/ERK/MAPK Pathways. Molecules, 23(11), 1-17. [More Information]
2017
- Minhas, N., Xue, M., Jackson, C. (2017). Activated protein C binds directly to Tie2: possible beneficial effects on endothelial barrier function. Cellular and Molecular Life Sciences, 74(10), 1895-1906. [More Information]
- Park, Y., Choi, J., Song, I., Jackson, C., Park, S., Seol, J. (2017). Differential effects of activated protein c on synovial fibroblasts in response to hypoxia and normoxia. Sains Malaysiana, 46(10), 1895-1902. [More Information]
- Xue, M., Lin, H., Zhao, R., Liang, H., Jackson, C. (2017). The differential expression of protease activated receptors contributes to functional differences between dark and fair keratinocytes. Journal of Dermatological Science, 85(3), 178-185. [More Information]
2016
- Nguyen, T., McKelvey, K., March, L., Hunter, D., Xue, M., Jackson, C., Morris, J. (2016). Aberrant levels of natural IgM antibodies in osteoarthritis and rheumatoid arthritis patients in comparison to healthy controls. Immunology Letters, 170, 27-36. [More Information]
- Wijewardena, A., Lajevardi, S., Vandervord, E., Vandervord, J., Lang, T., Fulcher, G., Jackson, C. (2016). Activated protein C to heal pressure ulcers. International Wound Journal, 13(5), 986-991. [More Information]
- Zhao, R., Liang, H., Clarke, E., Jackson, C., Xue, M. (2016). Inflammation in Chronic Wounds. International Journal of Molecular Sciences, 17(12), 1-14. [More Information]
2015
- Bischofberger, A., Tsang, A., Horadagoda, N., Dart, C., Perkins, N., Jeffcott, L., Jackson, C., Dart, A. (2015). Effect of activated protein C in second intention healing of equine distal limb wounds: a preliminary study. Australian Veterinary Journal, 93(10), 361-366. [More Information]
- Xue, M., Jackson, C. (2015). Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring. Advances in Wound Care, 4(3), 119-136. [More Information]
- Xue, M., Jackson, C. (2015). Novel Functions of the Anticoagulant Activated Protein C in Maintaining Skin Barrier Integrity to Impact on Skin Disease. Pathobiology: exploring the basis of disease, 82(2), 100-106. [More Information]
2014
- Shen, K., Murphy, C., Chan, B., Kolind, M., Cheng, T., Cheng, T., Mikulec, K., Peacock, L., Xue, M., Park, S., Little, D., Jackson, C., Schindeler, A. (2014). Activated Protein C (APC) can Increase Bone Anabolism via a Protease Activated Receptor (PAR)1/2 Dependent Mechanism. Journal of Orthopaedic Research, 32(12), 1549-1556. [More Information]
- McKelvey, K., Jackson, C., Xue, M. (2014). Activated protein C: A regulator of human skin epidermal keratinocyte function. World Journal of Biological Chemistry, 5(2), 169-179. [More Information]
- Jackson, M., Babak, M., Smith, M., Jackson, C., Little, C. (2014). Activation of matrix metalloproteinases 2, 9, and 13 by activated protein c in human osteoarthritic cartilage chondrocytes. Arthritis & Rheumatology, 66(6), 1525-1536. [More Information]
2013
- Lee, Y., Jeong, J., Seol, J., Xue, M., Jackson, C., Park, S. (2013). Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates. Experimental and Molecular Medicine, 45, 1-7. [More Information]
- Julovi, S., Shen, K., McKelvey, K., Minhas, N., March, L., Jackson, C. (2013). Activated Protein C Inhibits Proliferation and Tumour Necrosis Factor alpha-stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts. Molecular Medicine, 19, 324-331. [More Information]
- Akbari, M., Dadadashian, F., Kordestani, S., Xue, M., Jackson, C. (2013). Enzymatic modification of regenerated cellulosic fabrics to improve bacteria sorption properties. Journal of Biomedical Materials Research A, 101A (6), 1734-1742. [More Information]
2012
- Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]
- Xue, M., Dervish, S., Harrison, L., Fulcher, G., Jackson, C. (2012). Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice. Journal of Biological Chemistry, 287(20), 16356-16364. [More Information]
- McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012). Potential anti-inflammatory treatments for chronic wounds. Wound Practice & Research, 20(2), 86-89.
2011
- Xue, M., Chow, S., Dervish, S., Chan, Y., Julovi, S., Jackson, C. (2011). Activated Protein C Enhances Human Keratinocyte Barrier Integrity via Sequential Activation of Epidermal Growth Factor Receptor and Tie2. Journal of Biological Chemistry, 286(8), 6742-6750. [More Information]
- Seol, J., Lee, Y., Jackson, C., Sambrook, P., Park, S. (2011). Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-KB pathways. International Journal of Molecular Medicine, 27(6), 835-840. [More Information]
- Jackson, C., Xue, M. (2011). Anti-Inflammatory Actions of the Anticoagulant, Activated Protein C. In Amit Nagal (Eds.), Inflammatory Diseases - A Modern Perspective, (pp. 45-72). Rijeka: InTech Publishers. [More Information]
2010
- Minhas, N., Xue, M., Fukudome, K., Jackson, C. (2010). Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function. The FASEB Journal, 24(3), 873-881. [More Information]
- Nguyen, T., Little, C., Yenson, V., Jackson, C., McCracken, S., Warning, J., Stevens, V., Gallery, E., Morris, J. (2010). Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance. Journal of Autoimmunity, 35(1), 86-97. [More Information]
- Xue, M., Minhas, N., Chow, S., Dervish, S., Sambrook, P., March, L., Jackson, C. (2010). Endogenous protein C is essential for the functional integrity of human endothelial cells. Cellular and Molecular Life Sciences, 67(9), 1537-1546. [More Information]
2009
- Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009). Activated protein C mediates a healing phenotype in cultured tenocytes. Journal of Cellular and Molecular Medicine, 13(4), 749-757. [More Information]
- Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009). Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthritis & Rheumatology, 60(3), 780-791. [More Information]
- Xue, A., Xue, M., Jackson, C., Smith, R. (2009). Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling. International Journal of Biochemistry and Cell Biology, 41(8-9), 1731-1738. [More Information]
2008
- Jackson, C., Xue, M. (2008). Activated protein C-An anticoagulant that does more than stop clots. International Journal of Biochemistry and Cell Biology, 40(12), 2692-2697. [More Information]
- Xue, M., Jackson, C. (2008). Autocrine Actions of Matrix Metalloproteinase (MMP)-2 Counter the Effects of MMP-9 to Promote Survival and Prevent Terminal Differentiation of Cultured Human Keratinocytes. Journal of Investigative Dermatology, 128(11), 2676-2685. [More Information]
- Jackson, C., Whitmont, K., Tritton, S., March, L., Sambrook, P., Xue, M. (2008). New therapeutic applications for the anticoagulant, activated protein C. Expert Opinion on Biological Therapy, 8(8), 1109-1122. [More Information]
2007
- Wang, Y., Chang, H., Wertheim, D., Jones, A., Jackson, C., Coombes, A. (2007). Characterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery. Biomaterials, 28(31), 4619-4627. [More Information]
- Xue, M., March, L., Sambrook, P., Jackson, C. (2007). Differential Regulation of Matrix Metalloproteinase 2 and Matrix Metalloproteinase 9 by Activated Protein C: Relevance to Inflammation in Rheumatoid Arthritis. Arthritis & Rheumatology, 56(9), 2864-2874. [More Information]
- Xue, M., March, L., Sambrook, P., Fukudome, K., Jackson, C. (2007). Endothelial protein C receptor is over-expressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Annals of the Rheumatic Diseases, 66(12), 1574-1580. [More Information]
2006
- Jackson, C., Xue, M. (2006). Activated protein C (APC) as a novel agent to promote wound healing. Primary Intention, 14(1), 31-34.
- Xue, M., Thompson, P., Sambrook, P., March, L., Jackson, C. (2006). Activated protein C stimulates expression of angiogenic factors in human skin cells,angiogenesis in the chick embryo and cutaneous wound healing in rodents. Clinical Hemorheology and Microcirculation, 34, 153-161. [More Information]
- Au, C., Luk, S., Jackson, C., Ng, H., Yow, C., To, S. (2006). Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. Journal of Photochemistry and Photobiology B-Biology, 85(2), 92-101. [More Information]
2005
- Jackson, C., Xue, M., Thompson, P., Davey, R., Whitmont, K., Smith, S., Buisson-Legendre, N., Sztynda, T., Furphy, L., Cooper, A., Sambrook, P., March, L. (2005). Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing. Wound Repair and Regeneration, 13(3), 284-294. [More Information]
- Xue, M., Campbell, D., Sambrook, P., Fukudome, K., Jackson, C. (2005). Endothelial Protein C Receptor and Protease-Activated Receptor-1 Mediate Induction of a Wound-Healing Phenotype in Human Keratinocytes by Activated Protein C. Journal of Investigative Dermatology, 125(6), 1279-1285. [More Information]
- Xue, M., Thompson, P., Clifton-Bligh, R., Fulcher, G., Gallery, E., Jackson, C. (2005). Leukocyte matrix metalloproteinase-9 is elevated and contributes to lymphocyte activation in type I diabetes. International Journal of Biochemistry and Cell Biology, 37(11), 2406-2416. [More Information]
2004
- Xue, M., Thompson, P., Kelso, I., Jackson, C. (2004). Activated Protein C Stimulates Proliferation, Migration And Wound Closure, Inhibits Apoptosis And Upregulates Mmp-2 Activity In Cultured Human Keratinocytes. Experimental Cell Research, 299(1), 119-127. [More Information]
- Buisson-Legendre, N., Smith, S., March, L., Jackson, C. (2004). Elevation Of Activated Protein C In Synovial Joints In Rheumatoid Arthritis And Its Correlation With Matrix Metalloproteinase 2. Arthritis & Rheumatology, 50(7), 2151-2156. [More Information]
- Field, M., Jackson, C., Pollock, C., Poronnik, P., Young, B., Qi, W. (2004). Human Cortical Fibroblast Responses To High Glucose And Hypoxia. Nephron Journals, Nephron Physiology: Volume 96(4), 121-129. [More Information]
2003
- Jackson, C., Schrieber, L. (2003). Angiogenesis in rheumatoid arthritis. In M C Hochberg, A J Silman, J S Smolen, M E Weinblatt, M H Weisman (Eds.), Rheumatology: Third Edition, (pp. 851-854). Edinburgh: Mosby.
- Arkell, J., Jackson, C. (2003). Constitutive secretion of MMP9 by early-passage cultured human endothelial cells. Cell Biochemistry And Function, 21(4), 381-386. [More Information]
- Campbell, S., Rowe, J., Jackson, C., Gallery, E. (2003). In vitro migration of cytotrophoblasts through a decidual endothelial cell monolayer: the role of matrix metalloproteinases. Placenta, 24(4), 306-315. [More Information]
2002
- Jackson, C. (2002). Matrix metalloproteinases and angiogenesis. Current Opinion In Nephrology And Hypertension, 11(3), 295-299. [More Information]
2001
- Gallery, E., Campbell, B., Ilkovski, B., Sinosich, M., Jackson, C. (2001). A novel in-vitro co-culture system for the study of maternal decidual endothelial cell-trophoblast interactions in human pregnancy. BJOG, 108, 651-653.
- Nguyen, M., Arkell, J., Jackson, C. (2001). Endothelial cells and gelatinases. International Journal of Biochemistry and Cell Biology, 32, 621-631.
- Jackson, C., Nguyen,, M., Arkell, J., Sambrook, P. (2001). Selective matrix metalloproteinase (MMP) inhibition in rheumatoid arthritis - targetting gelatinase A activation. Inflammation Research, 50, 183-186.
Selected Grants
2019
- Loss of EPCR attenuates inflammatory arthritis in mice via inhibiting DC maturation and migration, Jackson C, Xue M, Arthritis Foundation of Australia/Project Grants
- EPCR deficiency attenuates rheumatoid arthritis in mice via inhibiting dentritic cell maturation and migration, Xue M, Jackson C, The Lincoln Centre/Research Grant
2018
- The importance of protease activated receptors and potential of peptides in inflammatory arthritis, Jackson C, Xue M, Perpetual Trustees Charitable Trusts/IMPACT Philanthropy Scheme
- The importance of protease activated receptors in inflammatory arthritis, Jackson C, Perpetual Trustees Charitable Trusts/IMPACT Philanthropy Scheme