Professor Christopher Jackson
Professor of Regenerative Science and Medicine
Medicine, Northern Clinical School
Kolling Institute of Medical Research
2014-present Professor, Medical School, University of Sydney
2006-2013 Associate Professor, Department of Medicine, University of Sydney
1999-present Director, Sutton Arthritis Research Laboratories,
Institute of Bone and Joint Research,
Kolling Institute, University of Sydney
1995-2003 Henry Langley Research Fellow, Department of Medicine, University of Sydney
1998-1999 Scientific Director, Sutton Arthritis Research Laboratories
1990-1998 Laboratory Manager, Sutton Rheumatism Research Laboratories
1993-1995 Research Fellow, Sutton Rheumatism Research Laboratories
1992: PhD University of Sydney
Recent research support as CI
· Four National Health and Medical Research Council (NHMRC) grants totalling $2.4 million(three as Principal Investigator) in past 7 years; 9 NHMRC grants overall
· Health Research Council NZ, Program grant, “Exploiting the therapeutic potential of viruses”, A Mercer with 9 CIs from NZ, USA and Australiaincl. C Jackson, NZ$5 million awarded 26/06/13. My role to provide expertise in pre-clinical and clinical trials in wound healing.
· JDRF International Innovative grant as CIA, 2009, US$102,000
· Korea National Research Foundation “Role of APC in treatment of BP-induced osteonecrosis of the jaw”, S Park, P Sambrook and C Jackson, E00019, A$550K, 2010-13. My role to perform cellular mechanistic studies e.g. osteoblasts. This grant resulted in 6 publications
· Ray and Pam Robinson award from Arthritis Australia in 2009 and 2013, $40,000 each
Patents and Industry
· Granted patents: “Treatment and Composition for Wound Healing” Inventors: C Jackson, P Sambrook 2002302192 Australia 2007; 4351041 Japan 2009; EP1404 412 B1 Europe 2012; 8728512 USA.
· PCT Pending 2013286812 Australia; 2,877,745 Canada; 201380034024 China; 13812528.1 Europe; 2015-518732 Japan; 10-2015-7002889 South Korea; 14/409,215 USA plus other countries :“Treatment for inflammatory skin disorders” Inventors: C Jackson, M Xue
· Provisional converted 2014901397Australia; PCT/AU2014/050323 World: “An agent that prevents/treats the abnormal cutaneous scaring”. Inventors: C Jackson, M Xue
· PCT filed 2014: “A treatmentfor bone defects” Inventors: C Jackson, K Shen, A Schindeler, D Little, M Xue and S-Y Park
· Provisional 2014902900 converted Australia; PCT/AU2015/050177 World: “Use of APC analogue for wound healing”. Inventors: C Jackson, M Xue
· Co-Founder of Bioatrix, a company dedicated to finding new treatments for skin diseases
· Bioatrix was acquired by the US company, ZZ-Biotech, in Dec 2015. ZZ-Biotech will begin a trial of 3K3A-APC in diabetic wounds in 2016
· Chair, Scientific Advisory Board, Bioatrix, which includes prominent medical researchers such as Professor Sir Marc Feldmann, University of Oxford.
Recent invitations to speak, international committees
· · FASEB Scientific Conference on “Proteases in Hemostatis and Vascular Biology”, Keystone, Colorado, June 2015
· International Society Thrombosis Haemostasis Conference, Milwaukee, USA, June 2014
· Inaugural International session, Wound Healing Society, SAWC Spring Symposium on Advanced Wound Care, Orlando, USA, April 2014
· 25th European Congress of Pathology, Lisbon, Portugal, July 2013
· Current society memberships: Australian Rheumatology Association, Int. Soc. Thrombosis Haemostasis, AWTRS, ANZMS.
Supervision and mentoring
Has supervised 20 PhD students, 15 to graduation and 4 current and mentored 7 Early- and Mid-Career post-doctoral fellows.
Peer review and Societies
· NHMRC Grant Review Panel member for project grants (2006, 2007, 2011)
· NHMRC Grant Review Panel for Early Career Fellowships (2009, 2015, 2016)
· Editorial board member for 5 journals incl. Pathobiology, Frontiers of Bioscience.
· Current Vice-President, Australasian Wound and Tissue Repair Society (AWTRS, 2012-2014)
· Past President, Australian and New Zealand Microcirculation Society (ANZMS, 2005-7)
· Session organiser or Committee Member for 15 conferences
· Current society memberships: Australian Rheumatology Association, Int. Soc. Thrombosis Haemostasis, AWTRS, ANZMS.
Dr Jackson’s research team is directly involved with several departments at Royal North Shore Hospital including Rheumatology, the Severe Burns Unit, Dermatology, Endocrinology and the Institute of Bone and Joint Research at the University of Sydney. Dr Jackson works closely with the clinicians and co-supervises PhD students from those departments. These strong links ensure that human specimens are readily available for his research. Additionally, they ensure that his research is patient-orientated with the ultimate aim of solving health issues related to arthritis, particularly rheumatoid arthritis, and inflammatory skin conditions.
The strategies used for Dr Jackson’s research has allowed it to become true bench to bedside translational research. After making the original discovery that activated protein C (APC) heals wounds, Dr Jackson was given the opportunity to develop the concept with an NHMRC Development Grant (#25388, Activated protein C to promote wound healing, 2003-5). Together with Dr Meilang Xue, he undertook extensive basic laboratory studies, including pre-clinical animal studies to obtain proof-of-concept. With help from his clinical colleagues at RNSH, he progressed the work to pilot human clinical trials in diabetic chronic wounds. With clinical collaborations firmly established and positive results from pilot studies showing that APC has strong potential to heal human chronic wounds, A randomised double-blind controlled clinical trial will shortly begin to test the efficacy of an APC variant to treat diabetic chronic leg ulcers, funded by NHMRC 1032549 grant and commercial sponsorship.
Current research students
|Project title||Research student|
|The effects of an activated protein C mutant, 3K3A-APC, on incisional wound healing in rats, and as a prognostic factor for burns wounds..||Ruilong ZHAO|
Honours project opportunities
(to be declared)
Prof David Hart is collaborating with us on the use of animal models for wound healing
(Hong Kong Polytehnic, Prof Tony To)
collaborative project on photoporphyrins and cancer
(Department of Immunology, Saga Medical School, Nabeshima, Saga, Japan)
Prof Fukudome provides essential tools and advice for our research on wound healing, arthritis and diabetes.
(College of Veterinary Medicine, Chonbuk National University, Jeonju)
awarded a Korean Government grant and share 5 publications
(Scripps, Prof John Griffin and Prof Charles Fisher)
provision of unique therapeutic agent for collaborative project
- What causes thrombotic complications in rheumatoid arthritis; Liang H, Xue M, Jackson C; The Lincoln Centre/Research Support.
- support research at the Sutton Arthritis Research Laboratory�? to help support the salary of Helena Laing; Jackson C; Sydney Medical School Foundation/Foundation Grant.
- A novel broad-acting therapy for inflammatory arthritis; Jackson C, Xue M, March L; Arthritis Australia/Project Grants.
- Novel therapy for rheumatoid arthritis patients; Jackson C, Liang H, Lin H; Ulysses Club Arthritis Research Fund/Research Grant.
- Can activated protein C reverse the aggressive properties of rheumatoid synoviocytes; Xue M, Jackson C, March L, Tonkin M; The Lincoln Centre/Research Support.
- DAMPENING THE AGGRESSIVE PROPERTIES OF RHEUMATOID SYNOVIAL FIBROBLASTS TO TREAT RHEUMATOID ARTHRITIS; Jackson C, Xue M; Arthritis Australia/Project Grants.
- Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer; Baxter R, Halliday G, Marsh D, Gill A, Clarke S, Smith R, Little C, Jackson C, O'Neill C, Murphy C, Sharland A, Chadban S, Mason R, Assinder S, Verdurand M, Richardson D, Machaalani R, Hambly B, Chan-Ling T, Dos Remedios C, Holsinger D, Lay P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Differential contributions of protease activated receptor (PAR)1 and PAR2 in the aggressive properties of synovial fibroblasts in rheumatoid arthritis; Xue M, Jackson C, March L, Sambrook P, Laurent R; Royal North Shore Hospital/Staff Specialist Trust Fund.
- Efficacy of Activated protein C to treat Diabetic Leg ulcers - a randomised, controlled clinical trial; Jackson C, Fulcher G, Wraight P, March L, Cooper A; National Health and Medical Research Council (NHMRC)/Project Grants.
- IncuCyte FLR Microscope System and Cell Incubator; Baxter R, Marsh D, Jackson C, O'Neill C, Ashton A, Howell V; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.
- IncuCyte FLR Microscope System (Essen Bioscience); Marsh D, Baxter R, Morris J, Jackson C, Howell V; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Role of Activated protein C in treatment of bisphosphonate-induced diseases including osteonecrosis of the jaw; Jackson C, Park S, Sambrook P; National Research Foundation of Korea/Research Support.
- How does activated protein C create intact, non-leaky, stable blood vessels; Jackson C, Xue M; National Health and Medical Research Council (NHMRC)/Project Grants.
- Novel pathways involving APC and PAR-2 in cartilage degradation in osteoarthritis; Little C, Jackson C; National Health and Medical Research Council (NHMRC)/Project Grants.
- The regulatory role of APC on arthritis; Jackson C, Xue M, Sambrook P, March L; Arthritis Australia/Project Grants.
- Prevention of type 1 diabetes by activated protein C (APC); Jackson C; Juvenile Diabetes Research Foundation/Research Support.
- Activated protein C utilises protease activated receptors and epidermal growth factor receptor to heal wounds; Jackson C, Xue M; National Health and Medical Research Council (NHMRC)/Project Grants.
- Safety and Efficacy of Activated protein C to treat Leg ulcers (SEAL)- a randonised, controlled clin; Jackson C; University of Sydney/Bridging Support.
- Prevention of type 1 diabetes by activated protein C; Jackson C, Xue M, Fulcher G, Harrison L; Juvenile Diabetes Research Foundation/Research Grants.
- Effect of APC on pancreas; Fulcher G, Jackson C, Xue M; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
- MT1-MMP is responsible for tendon invasion; Jackson C, Nanchahal J; University of Sydney/Bridging Support.
- The role of osteopontin in tenosynovitis; Le N, Nanchahal J, Jackson C; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
- Inverted Fluorescence Microscopy: A sensitive method used to visualise protein expression in live cells; Jackson C, Davey R, Little C, Morris J, Gallery E; BLO DETYA National School Drug Education Strategy/RIGB Grant.
- Identification of adhesion molecules responsible for monocyte activation in diabetic women; Gallery E, Morris J, Jackson C, Xie L; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
- Hypoxia gene regulation system; Gallery E, Jackson C, Morris J; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Why is trophoblast invasion defective in pregnancies that develop pre-eclampsia?; Gallery E, Jackson C, Morris J; National Health and Medical Research Council (NHMRC)/Project Grants.
- Interim Research Agreement (for Gap Funding); Quail D, Heathers G, Jackson C; Ucom Sixteen Pty Ltd/BLO Project.
- Clinical Fellowship to support the salary of Dr Jackson; Jackson C; The Lincoln Centre/Post-Doctoral Fellowships.
- The role of APC in the regulation of inflammation in RA; Xue M, Jackson C; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
- Monocyte-decidual endothelial interactions in diabetic pregnancies; Jackson C, Gallery E, Morris J; Diabetes Australia/Research Grant.
- Studies on the role of MT1-MMP in bone erosion; Nanchahal J, Jackson C; Rebecca L Cooper Medical Research Foundation/Research Grant.
- Performance of research assays; Jackson C; Northern Sydney Area Health Service/Research Grants Scheme.
- Understanding the mechanism of tendon invasion by tenosynovium in rheumatoid arthritis; Jackson C, Nanchahal J; Arthritis Foundation of Australia/Barbara Cameron Award.
- Monitoring genes expression in vascular disease and wounds using real-time PCR; Jackson C; BLO DETYA National School Drug Education Strategy/RIGB Grant.
- A new treatment to promote wound healing; Jackson C, Cooper A, March L; National Health and Medical Research Council (NHMRC)/Development Grants.
- Interactions of human monocytes and decidual endothelial cells in the development of vascular disease in diabetic pregnancy; Jackson C, Gallery E, Campbell S, Morris J; MAWA Trust/Research Grant.
- The use of a new agent to promote wound healing; Jackson C; University of Sydney/Vice Chancellor's Innovative Dev. Fund Seeding grant.
- Abnormal interactions between peripheral blood monocytes and decidual endothelial cells in acute atherosis in human pregnancy; Gallery E, Morris J, Jackson C, Twigg S; Diabetes Australia/Research Grant.
- Effect of green tea phenols on rheumatoid arthritic synovial cells; Jackson C; The Lincoln Centre/Research Grant.
- How is gelatinase B stored in endothelial cells; Jackson C, Nguyen M; Northern Sydney Area Health Service/Research Contract.
- The role of hyperglycaemia and hypoxia in mediating cytokine responses in diabetic nephropathy; Pollock C, Jackson C, Field M; National Health and Medical Research Council (NHMRC)/Project Grants.
- Activated protein C and endothelial invasion; Jackson C; Northern Sydney Area Health Service/Research Contract.
- The use of activated protein C to promote wound healing.; Hughes E, Pullen G, O'Donnell M, Eutick M, Jennings P, Stephens R, Crawford R, Grainger D, Jackson C, Wilkie S, Storey S, Little M, Woodward M, O'Kane S, Cantrell A, Colacino J; University of Sydney/Internal Research Grant Allocations - BLO.