Professor Christopher Jackson
Professor of Regenerative Science and Medicine
Medicine, Northern Clinical School
Kolling Institute of Medical Research
|Telephone||+61 2 9926 4814|
|Fax||+61 2 9926 6269|
|Curriculum vitae||Curriculum vitae|
2014 : Professor Regenerative Science and Medicine, University of Sydney
2006 : Associate Professor, Medicine, University of Sydney
1999 – present: Director, Sutton Arthritis Research Laboratory
1992: PhD University of Sydney
· Four NHMRC grants (three as CIA) since 2008
· Health Research Council of New Zealand, Program grant, “Exploiting the therapeutic potential of viruses”, Investigators: A Mercer with 10 CIs, NZ$5 million awarded 26/06/13. A collaboration between researchers in New Zealand, USA and Australia.
· JDRF International Innovative grant as CIA, 2009
· Korea National Research Foundation Project Grant “Role of APC in treatment of bisphosphonate-induced osteonecrosis of the jaw”, S Park, P Sambrook and C Jackson, 2010-12
· Ray and Pam Robinson award from Arthritis Australia in 2009 and 2013
Contribution to field of research
The research of Prof Jackson and his team has evolved to become true bench to bedside. After making the original discovery, Dr Jackson has undertaken extensive basic laboratory studies, followed by animal studies to obtain proof-of-concept that APC heals chronic wounds. He then linked with his clinical colleagues to conduct open label human trials. With positive results he was awarded a NHMRC grant, as CIA, for a Phase II clinical trial, currently being conducted. He is now poised to reveal a novel contribution of APC in orthopaedic medicine.
Patents and Industry
· Granted patents: “A new skin wound healing agent” Inventors: C Jackson and P Sambrook. 2002302192 Australia 2007; 4351041 Japan 2009; EP 1 404 412 B1 Europe 2012; USA pending
o These patents are licensed to Bioatrix, a new start-up company incorporated in 2013 and currently seeking funding to undertake large clinical trials in dermatological conditions
· Dr Jackson is co-Founder of Bioatrix & Chair, Scientific Advisory Board which includes prominent medical researchers.
· PCT filed Nov 2013: “Treatment for inflammatory skin disorders” Inventors: C Jackson, M Xue
· PCT filed Feb 2014: “A treatment for bone defects”
Collaborations and Community engagement
· Regular Invited Speaker, at the Institute of Bone and Joint Public Forums (~200 members of public attending), Kolling Auditorium, Oct 2009, and Nov 2011. Topic “Rheumatoid Arthritis”
· Regular Invited Speaker at Ulysses Club functions. Topic “Arthritis Research”
Professional Involvement and International Standing - including invitations to speak, international committees
· Current Vice-President, Australasian Wound and Tissue Repair Society (AWTRS, 2012-2014)
· Member Organising Committee for 11 conferences incl. AWTRS Scientific meeting, Gold Coast, 2014
· Regular invited speaker at international conferences, including:
o Invited speaker, Int Soc Thrombosis Haemostasis meeting, Milwaukee, USA, June 2014
o Invited speaker and Session Organizer, Inaugural International session, Wound Healing Society, SAWC Spring Symp on Advanced Wound Care, Orlando, USA, April 2014
o Invited Speaker, 25th European Congress of Pathology, Lisbon, Portugal, July 2013
o Invited Speaker, Biopharmaceutical Summit-2013, Frankfurt, Germany, July 2013
o Speaker, International Vascular Biology Meeting, Weisbaden, Germany, July, 2012
o Invited speaker, Chair, Session Organiser, ANZMS, Margaret River, WA, Nov 2011
o Invited Speaker, Chair & Session Organiser, Int. Microcirculation Congress, Paris, Sept 2010
o Speaker, European Tissue Repair Society, Gent, Belgium, Aug 2010
o Invited speaker and Chair, ANZ Microcirculation Society, Queenstown, 2009
o Speaker and Chair, International Society Thrombosis and Hemostasis, Boston, USA 2009
· Current society memberships: Australian Rheumatology Association, Int. Soc. Thrombosis Haemostasis, AWTRS, ANZMS.
Supervision and mentoring
Has supervised 19 PhD students, 15 to graduation and 4 current and mentored 7 Early- and Mid-Career post-doctoral fellows.
Peer review involvement
· NHMRC Grant Review Panel member for project grants (2006, 2007, 2011)
· NHMRC Grant Review Panel for Early Career Fellowships (2009, 2013)
· Grant assessor include NHMRC (2-3 grants/year since 1997), Arthritis Australia (1 grant/year since 1996), Diabetes Aust. (1 grant/year since 2006), Israel Science Foundation (3 grants), JDRF Int. (2 grants), National Arthritis Spain (3 grants), Anti-Cancer Council of Victoria (3 grants)
· Editorial board of five peer-review journals
Dr Jackson's research focuses on cellular and molecular mechanisms of inflammation in the fields of autoimmune disorders, particularly rheumatoid arthritis and chronic skin disorders. He has a special interest in two groups of enzymes known as the matrix metalloproteinases and the serine proteases. Novel molecular biological techniques are used to manipulate cellular systems. Some interesting recent discoveries have come from our work investigating the mechanisms of action of one of these enzymes, activated protein C (APC). His research team's experiments using cultured cells and animal wounding models provide very strong evidence that APC accelerates wound healing. This work extends beyond cutaneous ulcers and has application to the healing of other tissues such as cartilage and bone that have been damaged by either disease, such as arthritis, or injury. They have successfully translated their research work and are currently running clinical trials to examine the efficacy of APC to treat chronic leg ulcers. Multiple patent applications for new therapeutic interventions have arisen from work performed in the Sutton laboratories.
Honours project opportunities
(to be declared)
Prof David Hart is collaborating with us on the use of animal models for wound healing
(Hong Kong Polytehnic, Prof Tony To)
collaborative project on photoporphyrins and cancer
(Department of Immunology, Saga Medical School, Nabeshima, Saga, Japan)
Prof Fukudome provides essential tools and advice for our research on wound healing, arthritis and diabetes.
(College of Veterinary Medicine, Chonbuk National University, Jeonju)
awarded a Korean Government grant and share 5 publications
(Scripps, Prof John Griffin and Prof Charles Fisher)
provision of unique therapeutic agent for collaborative project
- Can activated protein C reverse the aggressive properties of rheumatoid synoviocytes; Xue M, Jackson C, March L, Tonkin M; The Lincoln Centre/Research Support.
- DAMPENING THE AGGRESSIVE PROPERTIES OF RHEUMATOID SYNOVIAL FIBROBLASTS TO TREAT RHEUMATOID ARTHRITIS; Jackson C, Xue M; Arthritis Australia/Project Grants.
- Efficacy of Activated protein C to treat Diabetic Leg ulcers - a randomised, controlled clinical trial; Jackson C, Fulcher G, Wraight P, March L, Cooper A; National Health and Medical Research Council (NHMRC)/Project Grants.
- Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer; Baxter R, Halliday G, Marsh D, Gill A, Clarke S, Smith R, Little C, Jackson C, O'Neill C, Murphy C, Sharland A, Chadban S, Mason R, Assinder S, Verdurand M, Richardson D, Machaalani R, Hambly B, Chan-Ling T, Dos Remedios C, Holsinger D, Lay P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Differential contributions of protease activated receptor (PAR)1 and PAR2 in the aggressive properties of synovial fibroblasts in rheumatoid arthritis; Xue M, Jackson C, March L, Sambrook P, Laurent R; Royal North Shore Hospital/Staff Specialist Trust Fund.
- IncuCyte FLR Microscope System and Cell Incubator; Baxter R, Marsh D, Jackson C, O'Neill C, Ashton A, Howell V; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.
- IncuCyte FLR Microscope System (Essen Bioscience); Marsh D, Baxter R, Morris J, Jackson C, Howell V; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Role of Activated protein C in treatment of bisphosphonate-induced diseases including osteonecrosis of the jaw; Jackson C, Park S, Sambrook P; National Research Foundation of Korea/Research Support.
- How does activated protein C create intact, non-leaky, stable blood vessels; Jackson C, Xue M; National Health and Medical Research Council (NHMRC)/Project Grants.
- The regulatory role of APC on arthritis; Jackson C, Xue M, Sambrook P, March L; Arthritis Australia/Project Grants.
- Novel pathways involving APC and PAR-2 in cartilage degradation in osteoarthritis; Little C, Jackson C; National Health and Medical Research Council (NHMRC)/Project Grants.
- Activated protein C utilises protease activated receptors and epidermal growth factor receptor to heal wounds; Jackson C, Xue M; National Health and Medical Research Council (NHMRC)/Project Grants.
- Safety and Efficacy of Activated protein C to treat Leg ulcers (SEAL)- a randonised, controlled clin; Jackson C; University of Sydney/Bridging Support.
- Prevention of type 1 diabetes by activated protein C; Jackson C, Xue M, Fulcher G, Harrison L; Juvenile Diabetes Research Foundation/Research Grants.
- Prevention of type 1 diabetes by activated protein C (APC); Jackson C; Juvenile Diabetes Research Foundation/Research Support.
- Effect of APC on pancreas; Fulcher G, Jackson C, Xue M; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
- MT1-MMP is responsible for tendon invasion; Jackson C, Nanchahal J; University of Sydney/Bridging Support.
- Identification of adhesion molecules responsible for monocyte activation in diabetic women; Gallery E, Morris J, Jackson C, Xie L; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
- Why is trophoblast invasion defective in pregnancies that develop pre-eclampsia?; Gallery E, Jackson C, Morris J; National Health and Medical Research Council (NHMRC)/Project Grants.
- Interim Research Agreement (for Gap Funding); Quail D, Heathers G, Jackson C; Ucom Sixteen Pty Ltd /BLO Project.
- The role of APC in the regulation of inflammation in RA; Xue M, Jackson C; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
- Clinical Fellowship to support the salary of Dr Jackson; Jackson C; The Lincoln Centre/Post-Doctoral Fellowships.
- The role of osteopontin in tenosynovitis; Le N, Nanchahal J, Jackson C; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
- Hypoxia gene regulation system; Gallery E, Jackson C, Morris J; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Inverted Fluorescence Microscopy: A sensitive method used to visualise protein expression in live cells; Jackson C, Davey R, Little C, Morris J, Gallery E; BLO DETYA National School Drug Education Strategy/RIGB Grant.
- Monocyte-decidual endothelial interactions in diabetic pregnancies; Jackson C, Gallery E, Morris J; Diabetes Australia/Research Grant.
- Studies on the role of MT1-MMP in bone erosion; Nanchahal J, Jackson C; Rebecca L Cooper Medical Research Foundation/Research Grant.
- Monitoring genes expression in vascular disease and wounds using real-time PCR; Jackson C; BLO DETYA National School Drug Education Strategy/RIGB Grant.
- Understanding the mechanism of tendon invasion by tenosynovium in rheumatoid arthritis; Jackson C, Nanchahal J; Arthritis Foundation of Australia/Barbara Cameron Award.
- Performance of research assays; Jackson C; Northern Sydney Area Health Service/Research Grants Scheme.
- A new treatment to promote wound healing; Jackson C, Cooper A, March L; National Health and Medical Research Council (NHMRC)/Development Grants.
- Interactions of human monocytes and decidual endothelial cells in the development of vascular disease in diabetic pregnancy; Jackson C, Gallery E, Campbell S, Morris J; MAWA Trust/Research Grant.
- The use of a new agent to promote wound healing; Jackson C; University of Sydney/Vice Chancellor's Innovative Dev. Fund Seeding grant.
- Abnormal interactions between peripheral blood monocytes and decidual endothelial cells in acute atherosis in human pregnancy; Gallery E, Morris J, Jackson C, Twigg S; Diabetes Australia/Research Grant.
- How is gelatinase B stored in endothelial cells; Jackson C, Nguyen M; Northern Sydney Area Health Service/Research Contract.
- Effect of green tea phenols on rheumatoid arthritic synovial cells; Jackson C; The Lincoln Centre/Research Grant.
- The use of activated protein C to promote wound healing.; Hughes E, Pullen G, O'Donnell M, Eutick M, Jennings P, Stephens R, Crawford R, Grainger D, Jackson C, Wilkie S, Storey S, Little M, Woodward M, O'Kane S, Cantrell A, Colacino J; University of Sydney/Internal Research Grant Allocations - BLO.
- The role of hyperglycaemia and hypoxia in mediating cytokine responses in diabetic nephropathy; Pollock C, Jackson C, Field M; National Health and Medical Research Council (NHMRC)/Project Grants.
- Activated protein C and endothelial invasion; Jackson C; Northern Sydney Area Health Service/Research Contract.