Professor Christopher Jackson

Professor of Regenerative Science and Medicine
Medicine, Northern Clinical School
Kolling Institute of Medical Research

Telephone +61 2 9926 4814
Fax +61 2 9926 6269

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Biographical details

Career summary

2014-present Professor, Medical School, University of Sydney

2006-2013 Associate Professor, Department of Medicine, University of Sydney

1999-present Director, Sutton Arthritis Research Laboratories,

Institute of Bone and Joint Research,

Kolling Institute, University of Sydney

1995-2003 Henry Langley Research Fellow, Department of Medicine, University of Sydney

1998-1999 Scientific Director, Sutton Arthritis Research Laboratories

1990-1998 Laboratory Manager, Sutton Rheumatism Research Laboratories

1993-1995 Research Fellow, Sutton Rheumatism Research Laboratories

1992: PhD University of Sydney

Recent research support as CI

· Four National Health and Medical Research Council (NHMRC) grants totalling $2.4 million(three as Principal Investigator) in past 7 years; 9 NHMRC grants overall

· Health Research Council NZ, Program grant, “Exploiting the therapeutic potential of viruses”, A Mercer with 9 CIs from NZ, USA and Australiaincl. C Jackson, NZ$5 million awarded 26/06/13. My role to provide expertise in pre-clinical and clinical trials in wound healing.

· JDRF International Innovative grant as CIA, 2009, US$102,000

· Korea National Research Foundation “Role of APC in treatment of BP-induced osteonecrosis of the jaw”, S Park, P Sambrook and C Jackson, E00019, A$550K, 2010-13. My role to perform cellular mechanistic studies e.g. osteoblasts. This grant resulted in 6 publications

· Ray and Pam Robinson award from Arthritis Australia in 2009 and 2013, $40,000 each

Patents and Industry

· Granted patents: “Treatment and Composition for Wound Healing” Inventors: C Jackson, P Sambrook 2002302192 Australia 2007; 4351041 Japan 2009; EP1404 412 B1 Europe 2012; 8728512 USA.

· PCT Pending 2013286812 Australia; 2,877,745 Canada; 201380034024 China; 13812528.1 Europe; 2015-518732 Japan; 10-2015-7002889 South Korea; 14/409,215 USA plus other countries :“Treatment for inflammatory skin disorders” Inventors: C Jackson, M Xue

· Provisional converted 2014901397Australia; PCT/AU2014/050323 World: “An agent that prevents/treats the abnormal cutaneous scaring”. Inventors: C Jackson, M Xue

· PCT filed 2014: “A treatmentfor bone defects” Inventors: C Jackson, K Shen, A Schindeler, D Little, M Xue and S-Y Park

· Provisional 2014902900 converted Australia; PCT/AU2015/050177 World: “Use of APC analogue for wound healing”. Inventors: C Jackson, M Xue

· Co-Founder of Bioatrix, a company dedicated to finding new treatments for skin diseases

· Bioatrix was acquired by the US company, ZZ-Biotech, in Dec 2015. ZZ-Biotech will begin a trial of 3K3A-APC in diabetic wounds in 2016

· Chair, Scientific Advisory Board, Bioatrix, which includes prominent medical researchers such as Professor Sir Marc Feldmann, University of Oxford.

Recent invitations to speak, international committees

· · FASEB Scientific Conference on “Proteases in Hemostatis and Vascular Biology”, Keystone, Colorado, June 2015

· International Society Thrombosis Haemostasis Conference, Milwaukee, USA, June 2014

· Inaugural International session, Wound Healing Society, SAWC Spring Symposium on Advanced Wound Care, Orlando, USA, April 2014

· 25th European Congress of Pathology, Lisbon, Portugal, July 2013

· Current society memberships: Australian Rheumatology Association, Int. Soc. Thrombosis Haemostasis, AWTRS, ANZMS.

Supervision and mentoring

Has supervised 20 PhD students, 15 to graduation and 4 current and mentored 7 Early- and Mid-Career post-doctoral fellows.

Peer review and Societies

· NHMRC Grant Review Panel member for project grants (2006, 2007, 2011)

· NHMRC Grant Review Panel for Early Career Fellowships (2009, 2015, 2016)

· Editorial board member for 5 journals incl. Pathobiology, Frontiers of Bioscience.

· Current Vice-President, Australasian Wound and Tissue Repair Society (AWTRS, 2012-2014)

· Past President, Australian and New Zealand Microcirculation Society (ANZMS, 2005-7)

· Session organiser or Committee Member for 15 conferences

· Current society memberships: Australian Rheumatology Association, Int. Soc. Thrombosis Haemostasis, AWTRS, ANZMS.

Research interests

Dr Jackson’s research team is directly involved with several departments at Royal North Shore Hospital including Rheumatology, the Severe Burns Unit, Dermatology, Endocrinology and the Institute of Bone and Joint Research at the University of Sydney. Dr Jackson works closely with the clinicians and co-supervises PhD students from those departments. These strong links ensure that human specimens are readily available for his research. Additionally, they ensure that his research is patient-orientated with the ultimate aim of solving health issues related to arthritis, particularly rheumatoid arthritis, and inflammatory skin conditions.

The strategies used for Dr Jackson’s research has allowed it to become true bench to bedside translational research. After making the original discovery that activated protein C (APC) heals wounds, Dr Jackson was given the opportunity to develop the concept with an NHMRC Development Grant (#25388, Activated protein C to promote wound healing, 2003-5). Together with Dr Meilang Xue, he undertook extensive basic laboratory studies, including pre-clinical animal studies to obtain proof-of-concept. With help from his clinical colleagues at RNSH, he progressed the work to pilot human clinical trials in diabetic chronic wounds. With clinical collaborations firmly established and positive results from pilot studies showing that APC has strong potential to heal human chronic wounds, A randomised double-blind controlled clinical trial will shortly begin to test the efficacy of an APC variant to treat diabetic chronic leg ulcers, funded by NHMRC 1032549 grant and commercial sponsorship.

International links

Canada

(to be declared) Prof David Hart is collaborating with us on the use of animal models for wound healing

Hong Kong S.A.R.

(Hong Kong Polytehnic, Prof Tony To) collaborative project on photoporphyrins and cancer

Japan

(Department of Immunology, Saga Medical School, Nabeshima, Saga, Japan) Prof Fukudome provides essential tools and advice for our research on wound healing, arthritis and diabetes.

Korea South

(College of Veterinary Medicine, Chonbuk National University, Jeonju) awarded a Korean Government grant and share 5 publications

United States

(Scripps, Prof John Griffin and Prof Charles Fisher) provision of unique therapeutic agent for collaborative project

Selected grants

2016

  • What causes thrombotic complications in rheumatoid arthritis; Liang H, Xue M, Jackson C; The Lincoln Centre/Research Support.
  • A novel broad-acting therapy for inflammatory arthritis; Jackson C, Xue M, March L; Arthritis Australia/Project Grants.

2015

  • Novel therapy for rheumatoid arthritis patients; Jackson C, Liang H; Ulysses Club Arthritis Research Fund/Research Grant.

2013

  • Can activated protein C reverse the aggressive properties of rheumatoid synoviocytes; Xue M, Jackson C, March L, Tonkin M; The Lincoln Centre/Research Support.
  • DAMPENING THE AGGRESSIVE PROPERTIES OF RHEUMATOID SYNOVIAL FIBROBLASTS TO TREAT RHEUMATOID ARTHRITIS; Jackson C, Xue M; Arthritis Australia/Project Grants.

2012

  • Efficacy of Activated protein C to treat Diabetic Leg ulcers - a randomised, controlled clinical trial; Jackson C, Fulcher G, Wraight P, March L, Cooper A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer; Baxter R, Halliday G, Marsh D, Gill A, Clarke S, Smith R, Little C, Jackson C, O'Neill C, Murphy C, Sharland A, Chadban S, Mason R, Assinder S, Verdurand M, Richardson D, Machaalani R, Hambly B, Chan-Ling T, Dos Remedios C, Holsinger D, Lay P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Differential contributions of protease activated receptor (PAR)1 and PAR2 in the aggressive properties of synovial fibroblasts in rheumatoid arthritis; Xue M, Jackson C, March L, Sambrook P, Laurent R; Royal North Shore Hospital/Staff Specialist Trust Fund.

2011

  • IncuCyte FLR Microscope System and Cell Incubator; Baxter R, Marsh D, Jackson C, O'Neill C, Ashton A, Howell V; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.
  • IncuCyte FLR Microscope System (Essen Bioscience); Marsh D, Baxter R, Morris J, Jackson C, Howell V; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Role of Activated protein C in treatment of bisphosphonate-induced diseases including osteonecrosis of the jaw; Jackson C, Park S, Sambrook P; National Research Foundation of Korea/Research Support.
  • How does activated protein C create intact, non-leaky, stable blood vessels; Jackson C, Xue M; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Novel pathways involving APC and PAR-2 in cartilage degradation in osteoarthritis; Little C, Jackson C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The regulatory role of APC on arthritis; Jackson C, Xue M, Sambrook P, March L; Arthritis Australia/Project Grants.

2008

  • Safety and Efficacy of Activated protein C to treat Leg ulcers (SEAL)- a randonised, controlled clin; Jackson C; University of Sydney/Bridging Support.
  • Prevention of type 1 diabetes by activated protein C (APC); Jackson C; Juvenile Diabetes Research Foundation/Research Support.
  • Activated protein C utilises protease activated receptors and epidermal growth factor receptor to heal wounds; Jackson C, Xue M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Prevention of type 1 diabetes by activated protein C; Jackson C, Xue M, Fulcher G, Harrison L; Juvenile Diabetes Research Foundation/Research Grants.

2007

  • Effect of APC on pancreas; Fulcher G, Jackson C, Xue M; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.

2006

  • MT1-MMP is responsible for tendon invasion; Jackson C, Nanchahal J; University of Sydney/Bridging Support.

2005

  • The role of APC in the regulation of inflammation in RA; Xue M, Jackson C; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
  • Interim Research Agreement (for Gap Funding); Quail D, Heathers G, Jackson C; Ucom Sixteen Pty Ltd/BLO Project.
  • Why is trophoblast invasion defective in pregnancies that develop pre-eclampsia?; Gallery E, Jackson C, Morris J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Identification of adhesion molecules responsible for monocyte activation in diabetic women; Gallery E, Morris J, Jackson C, Xie L; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
  • Hypoxia gene regulation system; Gallery E, Jackson C, Morris J; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The role of osteopontin in tenosynovitis; Le N, Nanchahal J, Jackson C; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
  • Inverted Fluorescence Microscopy: A sensitive method used to visualise protein expression in live cells; Jackson C, Davey R, Little C, Morris J, Gallery E; BLO DETYA National School Drug Education Strategy/RIGB Grant.
  • Clinical Fellowship to support the salary of Dr Jackson; Jackson C; The Lincoln Centre/Post-Doctoral Fellowships.

2004

  • Performance of research assays; Jackson C; Northern Sydney Area Health Service/Research Grants Scheme.
  • Monocyte-decidual endothelial interactions in diabetic pregnancies; Jackson C, Gallery E, Morris J; Diabetes Australia/Research Grant.
  • Monitoring genes expression in vascular disease and wounds using real-time PCR; Jackson C; BLO DETYA National School Drug Education Strategy/RIGB Grant.
  • Understanding the mechanism of tendon invasion by tenosynovium in rheumatoid arthritis; Jackson C, Nanchahal J; Arthritis Foundation of Australia/Barbara Cameron Award.
  • Studies on the role of MT1-MMP in bone erosion; Nanchahal J, Jackson C; Rebecca L Cooper Medical Research Foundation/Research Grant.

2003

  • A new treatment to promote wound healing; Jackson C, Cooper A, March L; National Health and Medical Research Council (NHMRC)/Development Grants.

2002

  • Interactions of human monocytes and decidual endothelial cells in the development of vascular disease in diabetic pregnancy; Jackson C, Gallery E, Campbell S, Morris J; MAWA Trust/Research Grant.
  • The use of a new agent to promote wound healing; Jackson C; University of Sydney/Vice Chancellor's Innovative Dev. Fund Seeding grant.
  • Abnormal interactions between peripheral blood monocytes and decidual endothelial cells in acute atherosis in human pregnancy; Gallery E, Morris J, Jackson C, Twigg S; Diabetes Australia/Research Grant.

2001

  • How is gelatinase B stored in endothelial cells; Jackson C, Nguyen M; Northern Sydney Area Health Service/Research Contract.
  • Effect of green tea phenols on rheumatoid arthritic synovial cells; Jackson C; The Lincoln Centre/Research Grant.

2000

  • The role of hyperglycaemia and hypoxia in mediating cytokine responses in diabetic nephropathy; Pollock C, Jackson C, Field M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The use of activated protein C to promote wound healing.; Hughes E, Pullen G, O'Donnell M, Eutick M, Jennings P, Stephens R, Crawford R, Grainger D, Jackson C, Wilkie S, Storey S, Little M, Woodward M, O'Kane S, Cantrell A, Colacino J; University of Sydney/Internal Research Grant Allocations - BLO.
  • Activated protein C and endothelial invasion; Jackson C; Northern Sydney Area Health Service/Research Contract.

Selected publications

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Book Chapters

  • Jackson, C., Xue, M. (2011). Anti-Inflammatory Actions of the Anticoagulant, Activated Protein C. In Amit Nagal (Eds.), Inflammatory Diseases - A Modern Perspective, (pp. 45-72). Rijeka: InTech Publishers.
  • Jackson, C., Schrieber, L. (2003). Angiogenesis in rheumatoid arthritis. In M C Hochberg, A J Silman, J S Smolen, M E Weinblatt, M H Weisman (Eds.), Rheumatology: Third Edition, (pp. 851-854). Edinburgh: Mosby.

Journals

  • Bischofberger, A., Tsang, A., Horadagoda, N., Dart, C., Perkins, N., Jeffcott, L., Jackson, C., Dart, A. (2015). Effect of activated protein C in second intention healing of equine distal limb wounds: a preliminary study. Australian Veterinary Journal, 93(10), 361-366. [More Information]
  • Xue, M., Jackson, C. (2015). Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring. Advances in Wound Care, 4(3), 119-136. [More Information]
  • Xue, M., Jackson, C. (2015). Novel Functions of the Anticoagulant Activated Protein C in Maintaining Skin Barrier Integrity to Impact on Skin Disease. Pathobiology: exploring the basis of disease, 82(2), 100-106. [More Information]
  • Whitmont, K., McKelvey, K., Fulcher, G., Reid, I., March, L., Xue, M., Cooper, A., Jackson, C. (2015). Treatment of chronic diabetic lower leg ulcers with activated protein C: a randomised placebo-controlled, double-blind pilot clinical trial. International Wound Journal, 12(4), 422-427. [More Information]
  • Shen, K., Murphy, C., Chan, B., Kolind, M., Cheng, T., Cheng, T., Mikulec, K., Peacock, L., Xue, M., Park, S., Little, D., Jackson, C., Schindeler, A. (2014). Activated Protein C (APC) can Increase Bone Anabolism via a Protease Activated Receptor (PAR)1/2 Dependent Mechanism. Journal of Orthopaedic Research, 32(12), 1549-1556. [More Information]
  • McKelvey, K., Jackson, C., Xue, M. (2014). Activated protein C: A regulator of human skin epidermal keratinocyte function. World Journal of Biological Chemistry, 5(2), 169-179. [More Information]
  • Jackson, M., Babak, M., Smith, M., Jackson, C., Little, C. (2014). Activation of matrix metalloproteinases 2, 9, and 13 by activated protein c in human osteoarthritic cartilage chondrocytes. Arthritis & Rheumatology, 66(6), 1525-1536. [More Information]
  • Jackson, M., Moradi, B., Zaki, S., Smith, M., McCracken, S., Smith, S., Jackson, C., Little, C. (2014). Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms. Arthritis & Rheumatology, 66(12), 3337-3348. [More Information]
  • Xue, M., McKelvey, K., Shen, K., Minhas, N., March, L., Park, S., Jackson, C. (2014). Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology, 53(12), 2270-2279. [More Information]
  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research & Therapy, 16(1), 1-12. [More Information]
  • Kapila, S., Reid, I., Dixit, S., Fulcher, G., March, L., Jackson, C., Cooper, A. (2014). Use of dermal injection of activated protein C for treatment of large chronic wounds secondary to pyoderma gangrenosum. Clinical and Experimental Dermatology, 39(7), 785-790. [More Information]
  • Lee, Y., Jeong, J., Seol, J., Xue, M., Jackson, C., Park, S. (2013). Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates. Experimental and Molecular Medicine, 45, 1-7. [More Information]
  • Julovi, S., Shen, K., McKelvey, K., Minhas, N., March, L., Jackson, C. (2013). Activated Protein C Inhibits Proliferation and Tumour Necrosis Factor alpha-stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts. Molecular Medicine, 19, 324-331. [More Information]
  • Akbari, M., Dadadashian, F., Kordestani, S., Xue, M., Jackson, C. (2013). Enzymatic modification of regenerated cellulosic fabrics to improve bacteria sorption properties. Journal of Biomedical Materials Research. Part A, 101A (6), 1734-1742. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]
  • Moon, M., Jeong, J., Lee, Y., Seol, J., Jackson, C., Park, S. (2013). SIRT1, a class III histone deacetylase, regulates TNF-alpha-induced inflammation in human chondrocytes. Osteoarthritis and Cartilage, 21(3), 470-480. [More Information]
  • Lee, Y., Jeong, J., Lee, J., Park, Y., Moon, J., Seol, J., Jackson, C., Park, S. (2013). Sphingosine-1-phosphate protects against bisphosphonate-induced HUVEC cell death via regulation of c-Jun-N-terminal kinase signaling. International Journal of Molecular Medicine, 31(4), 811-816. [More Information]
  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]
  • Xue, M., Dervish, S., Harrison, L., Fulcher, G., Jackson, C. (2012). Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice. Journal of Biological Chemistry, 287(20), 16356-16364. [More Information]
  • McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012). Potential anti-inflammatory treatments for chronic wounds. Wound Practice & Research, 20(2), 86-89.
  • Xue, M., Chan, A., Shen, K., Dervish, S., March, L., Sambrook, P., Jackson, C. (2012). Protease-Activated Receptor 2, Rather Than Protease-Activated Receptor 1, Contributes to the Aggressive Properties of Synovial Fibroblasts in Rheumatoid Arthritis. Arthritis & Rheumatology, 64(1), 88-98. [More Information]
  • Downey, A., Jackson, C., Harun, N., Cooper, A. (2012). Toxic epidermal necrolysis: Review of pathogenesis and management. Journal Of The American Academy Of Dermatology, 66(6), 995-1003. [More Information]
  • Xue, M., Chow, S., Dervish, S., Chan, Y., Julovi, S., Jackson, C. (2011). Activated Protein C Enhances Human Keratinocyte Barrier Integrity via Sequential Activation of Epidermal Growth Factor Receptor and Tie2. Journal of Biological Chemistry, 286(8), 6742-6750. [More Information]
  • Seol, J., Lee, Y., Jackson, C., Sambrook, P., Park, S. (2011). Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-KB pathways. International Journal of Molecular Medicine, 27(6), 835-840. [More Information]
  • Moon, M., Jeong, J., Seo, J., Seol, J., Lee, Y., Xue, M., Jackson, C., Park, S. (2011). Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation. Experimental and Molecular Medicine, 43(3), 138-145. [More Information]
  • Wijewardena, A., Vandervord, E., Lajevardi, S., Vandervord, J., Jackson, C. (2011). Combination of activated protein C and topical negative pressure rapidly regenerates granulation tissue over exposed bone to heal recalcitrant orthopedic wounds. The International Journal of Lower Extremity Wounds, 10(3), 146-151. [More Information]
  • Julovi, S., Ito, H., Nishitani, K., Jackson, C., Nakamura, T. (2011). Hyaluronan inhibits Matrix Metalloproteinase-13 in Human Arthritic Chondrocytes via CD44 and P38. Journal of Orthopaedic Research, 29(2), 258-264. [More Information]
  • Julovi, S., Xue, M., Dervish, S., Sambrook, P., March, L., Jackson, C. (2011). Protease Activated Receptor-2 Mediates Activated Protein C-Induced Cutaneous Wound Healing via Inhibition of p38. The American Journal of Pathology, 179(5), 2233-2242. [More Information]
  • Minhas, N., Xue, M., Fukudome, K., Jackson, C. (2010). Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function. The F A S E B Journal, 24(3), 873-881. [More Information]
  • Nguyen, T., Little, C., Yenson, V., Jackson, C., McCracken, S., Warning, J., Stevens, V., Gallery, E., Morris, J. (2010). Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance. Journal of Autoimmunity, 35(1), 86-97. [More Information]
  • Xue, M., Minhas, N., Chow, S., Dervish, S., Sambrook, P., March, L., Jackson, C. (2010). Endogenous protein C is essential for the functional integrity of human endothelial cells. Cellular and Molecular Life Sciences, 67(9), 1537-1546. [More Information]
  • Hunyor, S., Jackson, C. (2010). Microenvironment and Macroenvironment in Hypertensive Hearts. Boundaries and Silos-Can We Pick and Treat Diastolic Heart Failure? Hypertension, 55(6), 1312-3. [More Information]
  • Moon, M., Seol, J., Seo, J., Jeong, J., Lee, Y., Kim, I., Jackson, C., Sambrook, P., Park, S. (2010). Protective effect of hypoxia on bisphosphonate-related bone cell damage. Molecular Medicine Reports, 3(5), 869-875.
  • Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009). Activated protein C mediates a healing phenotype in cultured tenocytes. Journal of Cellular and Molecular Medicine, 13(4), 749-757. [More Information]
  • Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009). Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthritis & Rheumatology, 60(3), 780-791. [More Information]
  • Xue, A., Xue, M., Jackson, C., Smith, R. (2009). Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling. The International Journal of Biochemistry and Cell Biology, 41(8-9), 1731-1738. [More Information]
  • Jackson, C., Xue, M. (2008). Activated protein C-An anticoagulant that does more than stop clots. The International Journal of Biochemistry and Cell Biology, 40(12), 2692-2697. [More Information]
  • Xue, M., Jackson, C. (2008). Autocrine Actions of Matrix Metalloproteinase (MMP)-2 Counter the Effects of MMP-9 to Promote Survival and Prevent Terminal Differentiation of Cultured Human Keratinocytes. Journal of Investigative Dermatology, 128(11), 2676-2685. [More Information]
  • Jackson, C., Whitmont, K., Tritton, S., March, L., Sambrook, P., Xue, M. (2008). New therapeutic applications for the anticoagulant, activated protein C. Expert Opinion on Biological Therapy, 8(8), 1109-1122. [More Information]
  • Whitmont, K., Reid, I., Tritton, S., March, L., Xue, M., Lee, M., Fulcher, G., Sambrook, P., Slobedman, E., Cooper, A., Jackson, C. (2008). Treatment of chronic leg ulcers with topical activated protein C. Archives of Dermatology, 144(11), 1479-1483. [More Information]
  • Wang, Y., Chang, H., Wertheim, D., Jones, A., Jackson, C., Coombes, A. (2007). Characterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery. Biomaterials, 28(31), 4619-4627. [More Information]
  • Xue, M., March, L., Sambrook, P., Jackson, C. (2007). Differential Regulation of Matrix Metalloproteinase 2 and Matrix Metalloproteinase 9 by Activated Protein C: Relevance to Inflammation in Rheumatoid Arthritis. Arthritis & Rheumatology, 56(9), 2864-2874. [More Information]
  • Xue, M., March, L., Sambrook, P., Fukudome, K., Jackson, C. (2007). Endothelial protein C receptor is over-expressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Annals of the Rheumatic Diseases, 66(12), 1574-1580. [More Information]
  • Xie, L., Galettis, A., Morris, J., Jackson, C., Twigg, S., Gallery, E. (2007). Intercellular adhesion molecule-1 (ICAM-1) expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy. Diabetes - Metabolism: Research and Reviews, Online: 7 Nov 2007, 1-9. [More Information]
  • Gallagher, G., Jackson, C., Hunyor, S. (2007). Myocardial extracellular matrix remodelling in ischemic heart failure. Frontiers in Bioscience, 12(4), 1410-1419. [More Information]
  • Xue, M., Campbell, D., Jackson, C. (2007). Protein C is an autocrine growth factor for human skin keratinocytes. Journal of Biological Chemistry, 282(18), 13610-13616. [More Information]
  • Le, N., Xue, M., Castelnoble, L., Jackson, C. (2007). The dual personalities of matrix metalloproteinases in inflammation. Frontiers in Bioscience, 12, 1475-1487. [More Information]
  • Jackson, C., Xue, M. (2006). Activated protein C (APC) as a novel agent to promote wound healing. Primary Intention, 14(1), 31-34.
  • Xue, M., Thompson, P., Sambrook, P., March, L., Jackson, C. (2006). Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents. Clinical Hemorheology and Microcirculation, 34, 153-161. [More Information]
  • Au, C., Luk, S., Jackson, C., Ng, H., Yow, C., To, S. (2006). Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. Journal of Photochemistry and Photobiology B-Biology, 85(2), 92-101.
  • Gallagher, G., Menzie, S., Huang, Y., Jackson, C., Hunyor, S. (2006). Regional cardiac dysfunction is associated with specific alterations in inflammatory cytokines and matrix metalloproteinases after acute myocardial infarction in sheep. Basic Research in Cardiology. [More Information]
  • Xue, M., Jackson, C., Le, N. (2006). Targeting matrix metalloproteases to improve cutaneous wound healing. Expert Opinion on Therapeutic Targets, 10(1), 143-155. [More Information]
  • Jackson, C., Xue, M., Thompson, P., Davey, R., Whitmont, K., Smith, S., Buisson-Legendre, N., Sztynda, T., Furphy, L., Cooper, A., Sambrook, P., March, L. (2005). Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing. Wound Repair and Regeneration, 13(3), 284-294. [More Information]
  • Xue, M., Campbell, D., Sambrook, P., Fukudome, K., Jackson, C. (2005). Endothelial Protein C Receptor and Protease-Activated Receptor-1 Mediate Induction of a Wound-Healing Phenotype in Human Keratinocytes by Activated Protein C. Journal of Investigative Dermatology, 125(6), 1279-1285. [More Information]
  • Xue, M., Thompson, P., Clifton-Bligh, R., Fulcher, G., Gallery, E., Jackson, C. (2005). Leukocyte matrix metalloproteinase-9 is elevated and contributes to lymphocyte activation in type I diabetes. The International Journal of Biochemistry and Cell Biology, 37(11), 2406-2416. [More Information]
  • Xue, M., Thompson, P., Kelso, I., Jackson, C. (2004). Activated Protein C Stimulates Proliferation, Migration And Wound Closure, Inhibits Apoptosis And Upregulates Mmp-2 Activity In Cultured Human Keratinocytes. Experimental Cell Research, 299(1), 119-127.
  • Buisson-Legendre, N., Smith, S., March, L., Jackson, C. (2004). Elevation Of Activated Protein C In Synovial Joints In Rheumatoid Arthritis And Its Correlation With Matrix Metalloproteinase 2. Arthritis & Rheumatology, 50(7), 2151-2156. [More Information]
  • Field, M., Jackson, C., Pollock, C., Poronnik, P., Young, B., Qi, W. (2004). Human Cortical Fibroblast Responses To High Glucose And Hypoxia. Nephron Journals, Nephron Physiology: Volume 96(4), 121-129.
  • Campbell, S., Rowe, J., Jackson, C., Gallery, E. (2004). Interaction Of Cocultured Decidual Endothelial Cells And Cytotrophoblasts In Preeclampsia. Biology Of Reproduction, 71(1), 244-252.
  • Galettis, A., Campbell, S., Morris, J., Jackson, C., Twigg, S., Gallery, E. (2004). Monocyte adhesion to decidual endothelial cells is increased in pregnancies complicated by Type 1 diabetes but not by gestational diabetes. Diabetes Care, 27(10), 2514-2515.
  • Arkell, J., Jackson, C. (2003). Constitutive secretion of MMP9 by early-passage cultured human endothelial cells. Cell Biochemistry And Function, 21(4), 381-386. [More Information]
  • Campbell, S., Rowe, J., Jackson, C., Gallery, E. (2003). In vitro migration of cytotrophoblasts through a decidual endothelial cell monolayer: the role of matrix metalloproteinases. Placenta, 24(4), 306-315.
  • Jackson, C. (2002). Matrix metalloproteinases and angiogenesis. Current Opinion In Nephrology And Hypertension, 11(3), 295-299.
  • Gallery, E., Campbell, B., Ilkovski, B., Sinosich, M., Jackson, C. (2001). A novel in-vitro co-culture system for the study of maternal decidual endothelial cell-trophoblast interactions in human pregnancy. BJOG, 108, 651-653.
  • Nguyen, M., Arkell, J., Jackson, C. (2001). Endothelial cells and gelatinases. The International Journal of Biochemistry and Cell Biology, 32, 621-631.
  • Jackson, C., Nguyen,, M., Arkell, J., Sambrook, P. (2001). Selective matrix metalloproteinase (MMP) inhibition in rheumatoid arthritis - targetting gelatinase A activation. Inflammation Research, 50, 183-186.

Conferences

  • Little, C., Jackson, M., Smith, M., Burkhardt, D., Xue, M., Jackson, C. (2006). Potential role of activated protein C (APC) in articular cartilage degeneration. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.

Patents

  • Jackson, C., Sambrook, P. (2013). Treatment and composition for wound healing (EPO). Patent No. 1404412, 2002302192, 4351041, BE1404412, CH1404412, DE1404412, EP1404412, ES1404412, FR1404412, IE1404412, IT1404412, LU1404412, MC1404412, NL1404412, US20130280234 A1. Belgium, France, Germany, Ireland, Italy, Liechtenstein, Luxembourg, Monaco, Netherlands, Spain, Switzerland.

2015

  • Bischofberger, A., Tsang, A., Horadagoda, N., Dart, C., Perkins, N., Jeffcott, L., Jackson, C., Dart, A. (2015). Effect of activated protein C in second intention healing of equine distal limb wounds: a preliminary study. Australian Veterinary Journal, 93(10), 361-366. [More Information]
  • Xue, M., Jackson, C. (2015). Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring. Advances in Wound Care, 4(3), 119-136. [More Information]
  • Xue, M., Jackson, C. (2015). Novel Functions of the Anticoagulant Activated Protein C in Maintaining Skin Barrier Integrity to Impact on Skin Disease. Pathobiology: exploring the basis of disease, 82(2), 100-106. [More Information]
  • Whitmont, K., McKelvey, K., Fulcher, G., Reid, I., March, L., Xue, M., Cooper, A., Jackson, C. (2015). Treatment of chronic diabetic lower leg ulcers with activated protein C: a randomised placebo-controlled, double-blind pilot clinical trial. International Wound Journal, 12(4), 422-427. [More Information]

2014

  • Shen, K., Murphy, C., Chan, B., Kolind, M., Cheng, T., Cheng, T., Mikulec, K., Peacock, L., Xue, M., Park, S., Little, D., Jackson, C., Schindeler, A. (2014). Activated Protein C (APC) can Increase Bone Anabolism via a Protease Activated Receptor (PAR)1/2 Dependent Mechanism. Journal of Orthopaedic Research, 32(12), 1549-1556. [More Information]
  • McKelvey, K., Jackson, C., Xue, M. (2014). Activated protein C: A regulator of human skin epidermal keratinocyte function. World Journal of Biological Chemistry, 5(2), 169-179. [More Information]
  • Jackson, M., Babak, M., Smith, M., Jackson, C., Little, C. (2014). Activation of matrix metalloproteinases 2, 9, and 13 by activated protein c in human osteoarthritic cartilage chondrocytes. Arthritis & Rheumatology, 66(6), 1525-1536. [More Information]
  • Jackson, M., Moradi, B., Zaki, S., Smith, M., McCracken, S., Smith, S., Jackson, C., Little, C. (2014). Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms. Arthritis & Rheumatology, 66(12), 3337-3348. [More Information]
  • Xue, M., McKelvey, K., Shen, K., Minhas, N., March, L., Park, S., Jackson, C. (2014). Endogenous MMP-9 and not MMP-2 promotes rheumatoid synovial fibroblast survival, inflammation and cartilage degradation. Rheumatology, 53(12), 2270-2279. [More Information]
  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research & Therapy, 16(1), 1-12. [More Information]
  • Kapila, S., Reid, I., Dixit, S., Fulcher, G., March, L., Jackson, C., Cooper, A. (2014). Use of dermal injection of activated protein C for treatment of large chronic wounds secondary to pyoderma gangrenosum. Clinical and Experimental Dermatology, 39(7), 785-790. [More Information]

2013

  • Lee, Y., Jeong, J., Seol, J., Xue, M., Jackson, C., Park, S. (2013). Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates. Experimental and Molecular Medicine, 45, 1-7. [More Information]
  • Julovi, S., Shen, K., McKelvey, K., Minhas, N., March, L., Jackson, C. (2013). Activated Protein C Inhibits Proliferation and Tumour Necrosis Factor alpha-stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts. Molecular Medicine, 19, 324-331. [More Information]
  • Akbari, M., Dadadashian, F., Kordestani, S., Xue, M., Jackson, C. (2013). Enzymatic modification of regenerated cellulosic fabrics to improve bacteria sorption properties. Journal of Biomedical Materials Research. Part A, 101A (6), 1734-1742. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]
  • Moon, M., Jeong, J., Lee, Y., Seol, J., Jackson, C., Park, S. (2013). SIRT1, a class III histone deacetylase, regulates TNF-alpha-induced inflammation in human chondrocytes. Osteoarthritis and Cartilage, 21(3), 470-480. [More Information]
  • Lee, Y., Jeong, J., Lee, J., Park, Y., Moon, J., Seol, J., Jackson, C., Park, S. (2013). Sphingosine-1-phosphate protects against bisphosphonate-induced HUVEC cell death via regulation of c-Jun-N-terminal kinase signaling. International Journal of Molecular Medicine, 31(4), 811-816. [More Information]
  • Jackson, C., Sambrook, P. (2013). Treatment and composition for wound healing (EPO). Patent No. 1404412, 2002302192, 4351041, BE1404412, CH1404412, DE1404412, EP1404412, ES1404412, FR1404412, IE1404412, IT1404412, LU1404412, MC1404412, NL1404412, US20130280234 A1. Belgium, France, Germany, Ireland, Italy, Liechtenstein, Luxembourg, Monaco, Netherlands, Spain, Switzerland.

2012

  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]
  • Xue, M., Dervish, S., Harrison, L., Fulcher, G., Jackson, C. (2012). Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice. Journal of Biological Chemistry, 287(20), 16356-16364. [More Information]
  • McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012). Potential anti-inflammatory treatments for chronic wounds. Wound Practice & Research, 20(2), 86-89.
  • Xue, M., Chan, A., Shen, K., Dervish, S., March, L., Sambrook, P., Jackson, C. (2012). Protease-Activated Receptor 2, Rather Than Protease-Activated Receptor 1, Contributes to the Aggressive Properties of Synovial Fibroblasts in Rheumatoid Arthritis. Arthritis & Rheumatology, 64(1), 88-98. [More Information]
  • Downey, A., Jackson, C., Harun, N., Cooper, A. (2012). Toxic epidermal necrolysis: Review of pathogenesis and management. Journal Of The American Academy Of Dermatology, 66(6), 995-1003. [More Information]

2011

  • Xue, M., Chow, S., Dervish, S., Chan, Y., Julovi, S., Jackson, C. (2011). Activated Protein C Enhances Human Keratinocyte Barrier Integrity via Sequential Activation of Epidermal Growth Factor Receptor and Tie2. Journal of Biological Chemistry, 286(8), 6742-6750. [More Information]
  • Seol, J., Lee, Y., Jackson, C., Sambrook, P., Park, S. (2011). Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-KB pathways. International Journal of Molecular Medicine, 27(6), 835-840. [More Information]
  • Jackson, C., Xue, M. (2011). Anti-Inflammatory Actions of the Anticoagulant, Activated Protein C. In Amit Nagal (Eds.), Inflammatory Diseases - A Modern Perspective, (pp. 45-72). Rijeka: InTech Publishers.
  • Moon, M., Jeong, J., Seo, J., Seol, J., Lee, Y., Xue, M., Jackson, C., Park, S. (2011). Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation. Experimental and Molecular Medicine, 43(3), 138-145. [More Information]
  • Wijewardena, A., Vandervord, E., Lajevardi, S., Vandervord, J., Jackson, C. (2011). Combination of activated protein C and topical negative pressure rapidly regenerates granulation tissue over exposed bone to heal recalcitrant orthopedic wounds. The International Journal of Lower Extremity Wounds, 10(3), 146-151. [More Information]
  • Julovi, S., Ito, H., Nishitani, K., Jackson, C., Nakamura, T. (2011). Hyaluronan inhibits Matrix Metalloproteinase-13 in Human Arthritic Chondrocytes via CD44 and P38. Journal of Orthopaedic Research, 29(2), 258-264. [More Information]
  • Julovi, S., Xue, M., Dervish, S., Sambrook, P., March, L., Jackson, C. (2011). Protease Activated Receptor-2 Mediates Activated Protein C-Induced Cutaneous Wound Healing via Inhibition of p38. The American Journal of Pathology, 179(5), 2233-2242. [More Information]

2010

  • Minhas, N., Xue, M., Fukudome, K., Jackson, C. (2010). Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function. The F A S E B Journal, 24(3), 873-881. [More Information]
  • Nguyen, T., Little, C., Yenson, V., Jackson, C., McCracken, S., Warning, J., Stevens, V., Gallery, E., Morris, J. (2010). Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance. Journal of Autoimmunity, 35(1), 86-97. [More Information]
  • Xue, M., Minhas, N., Chow, S., Dervish, S., Sambrook, P., March, L., Jackson, C. (2010). Endogenous protein C is essential for the functional integrity of human endothelial cells. Cellular and Molecular Life Sciences, 67(9), 1537-1546. [More Information]
  • Hunyor, S., Jackson, C. (2010). Microenvironment and Macroenvironment in Hypertensive Hearts. Boundaries and Silos-Can We Pick and Treat Diastolic Heart Failure? Hypertension, 55(6), 1312-3. [More Information]
  • Moon, M., Seol, J., Seo, J., Jeong, J., Lee, Y., Kim, I., Jackson, C., Sambrook, P., Park, S. (2010). Protective effect of hypoxia on bisphosphonate-related bone cell damage. Molecular Medicine Reports, 3(5), 869-875.

2009

  • Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009). Activated protein C mediates a healing phenotype in cultured tenocytes. Journal of Cellular and Molecular Medicine, 13(4), 749-757. [More Information]
  • Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009). Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthritis & Rheumatology, 60(3), 780-791. [More Information]
  • Xue, A., Xue, M., Jackson, C., Smith, R. (2009). Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling. The International Journal of Biochemistry and Cell Biology, 41(8-9), 1731-1738. [More Information]

2008

  • Jackson, C., Xue, M. (2008). Activated protein C-An anticoagulant that does more than stop clots. The International Journal of Biochemistry and Cell Biology, 40(12), 2692-2697. [More Information]
  • Xue, M., Jackson, C. (2008). Autocrine Actions of Matrix Metalloproteinase (MMP)-2 Counter the Effects of MMP-9 to Promote Survival and Prevent Terminal Differentiation of Cultured Human Keratinocytes. Journal of Investigative Dermatology, 128(11), 2676-2685. [More Information]
  • Jackson, C., Whitmont, K., Tritton, S., March, L., Sambrook, P., Xue, M. (2008). New therapeutic applications for the anticoagulant, activated protein C. Expert Opinion on Biological Therapy, 8(8), 1109-1122. [More Information]
  • Whitmont, K., Reid, I., Tritton, S., March, L., Xue, M., Lee, M., Fulcher, G., Sambrook, P., Slobedman, E., Cooper, A., Jackson, C. (2008). Treatment of chronic leg ulcers with topical activated protein C. Archives of Dermatology, 144(11), 1479-1483. [More Information]

2007

  • Wang, Y., Chang, H., Wertheim, D., Jones, A., Jackson, C., Coombes, A. (2007). Characterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery. Biomaterials, 28(31), 4619-4627. [More Information]
  • Xue, M., March, L., Sambrook, P., Jackson, C. (2007). Differential Regulation of Matrix Metalloproteinase 2 and Matrix Metalloproteinase 9 by Activated Protein C: Relevance to Inflammation in Rheumatoid Arthritis. Arthritis & Rheumatology, 56(9), 2864-2874. [More Information]
  • Xue, M., March, L., Sambrook, P., Fukudome, K., Jackson, C. (2007). Endothelial protein C receptor is over-expressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Annals of the Rheumatic Diseases, 66(12), 1574-1580. [More Information]
  • Xie, L., Galettis, A., Morris, J., Jackson, C., Twigg, S., Gallery, E. (2007). Intercellular adhesion molecule-1 (ICAM-1) expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy. Diabetes - Metabolism: Research and Reviews, Online: 7 Nov 2007, 1-9. [More Information]
  • Gallagher, G., Jackson, C., Hunyor, S. (2007). Myocardial extracellular matrix remodelling in ischemic heart failure. Frontiers in Bioscience, 12(4), 1410-1419. [More Information]
  • Xue, M., Campbell, D., Jackson, C. (2007). Protein C is an autocrine growth factor for human skin keratinocytes. Journal of Biological Chemistry, 282(18), 13610-13616. [More Information]
  • Le, N., Xue, M., Castelnoble, L., Jackson, C. (2007). The dual personalities of matrix metalloproteinases in inflammation. Frontiers in Bioscience, 12, 1475-1487. [More Information]

2006

  • Jackson, C., Xue, M. (2006). Activated protein C (APC) as a novel agent to promote wound healing. Primary Intention, 14(1), 31-34.
  • Xue, M., Thompson, P., Sambrook, P., March, L., Jackson, C. (2006). Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents. Clinical Hemorheology and Microcirculation, 34, 153-161. [More Information]
  • Au, C., Luk, S., Jackson, C., Ng, H., Yow, C., To, S. (2006). Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. Journal of Photochemistry and Photobiology B-Biology, 85(2), 92-101.
  • Little, C., Jackson, M., Smith, M., Burkhardt, D., Xue, M., Jackson, C. (2006). Potential role of activated protein C (APC) in articular cartilage degeneration. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Gallagher, G., Menzie, S., Huang, Y., Jackson, C., Hunyor, S. (2006). Regional cardiac dysfunction is associated with specific alterations in inflammatory cytokines and matrix metalloproteinases after acute myocardial infarction in sheep. Basic Research in Cardiology. [More Information]
  • Xue, M., Jackson, C., Le, N. (2006). Targeting matrix metalloproteases to improve cutaneous wound healing. Expert Opinion on Therapeutic Targets, 10(1), 143-155. [More Information]

2005

  • Jackson, C., Xue, M., Thompson, P., Davey, R., Whitmont, K., Smith, S., Buisson-Legendre, N., Sztynda, T., Furphy, L., Cooper, A., Sambrook, P., March, L. (2005). Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing. Wound Repair and Regeneration, 13(3), 284-294. [More Information]
  • Xue, M., Campbell, D., Sambrook, P., Fukudome, K., Jackson, C. (2005). Endothelial Protein C Receptor and Protease-Activated Receptor-1 Mediate Induction of a Wound-Healing Phenotype in Human Keratinocytes by Activated Protein C. Journal of Investigative Dermatology, 125(6), 1279-1285. [More Information]
  • Xue, M., Thompson, P., Clifton-Bligh, R., Fulcher, G., Gallery, E., Jackson, C. (2005). Leukocyte matrix metalloproteinase-9 is elevated and contributes to lymphocyte activation in type I diabetes. The International Journal of Biochemistry and Cell Biology, 37(11), 2406-2416. [More Information]

2004

  • Xue, M., Thompson, P., Kelso, I., Jackson, C. (2004). Activated Protein C Stimulates Proliferation, Migration And Wound Closure, Inhibits Apoptosis And Upregulates Mmp-2 Activity In Cultured Human Keratinocytes. Experimental Cell Research, 299(1), 119-127.
  • Buisson-Legendre, N., Smith, S., March, L., Jackson, C. (2004). Elevation Of Activated Protein C In Synovial Joints In Rheumatoid Arthritis And Its Correlation With Matrix Metalloproteinase 2. Arthritis & Rheumatology, 50(7), 2151-2156. [More Information]
  • Field, M., Jackson, C., Pollock, C., Poronnik, P., Young, B., Qi, W. (2004). Human Cortical Fibroblast Responses To High Glucose And Hypoxia. Nephron Journals, Nephron Physiology: Volume 96(4), 121-129.
  • Campbell, S., Rowe, J., Jackson, C., Gallery, E. (2004). Interaction Of Cocultured Decidual Endothelial Cells And Cytotrophoblasts In Preeclampsia. Biology Of Reproduction, 71(1), 244-252.
  • Galettis, A., Campbell, S., Morris, J., Jackson, C., Twigg, S., Gallery, E. (2004). Monocyte adhesion to decidual endothelial cells is increased in pregnancies complicated by Type 1 diabetes but not by gestational diabetes. Diabetes Care, 27(10), 2514-2515.

2003

  • Jackson, C., Schrieber, L. (2003). Angiogenesis in rheumatoid arthritis. In M C Hochberg, A J Silman, J S Smolen, M E Weinblatt, M H Weisman (Eds.), Rheumatology: Third Edition, (pp. 851-854). Edinburgh: Mosby.
  • Arkell, J., Jackson, C. (2003). Constitutive secretion of MMP9 by early-passage cultured human endothelial cells. Cell Biochemistry And Function, 21(4), 381-386. [More Information]
  • Campbell, S., Rowe, J., Jackson, C., Gallery, E. (2003). In vitro migration of cytotrophoblasts through a decidual endothelial cell monolayer: the role of matrix metalloproteinases. Placenta, 24(4), 306-315.

2002

  • Jackson, C. (2002). Matrix metalloproteinases and angiogenesis. Current Opinion In Nephrology And Hypertension, 11(3), 295-299.

2001

  • Gallery, E., Campbell, B., Ilkovski, B., Sinosich, M., Jackson, C. (2001). A novel in-vitro co-culture system for the study of maternal decidual endothelial cell-trophoblast interactions in human pregnancy. BJOG, 108, 651-653.
  • Nguyen, M., Arkell, J., Jackson, C. (2001). Endothelial cells and gelatinases. The International Journal of Biochemistry and Cell Biology, 32, 621-631.
  • Jackson, C., Nguyen,, M., Arkell, J., Sambrook, P. (2001). Selective matrix metalloproteinase (MMP) inhibition in rheumatoid arthritis - targetting gelatinase A activation. Inflammation Research, 50, 183-186.

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