Professor Christopher Jackson

Professor of Repair and Regeneration
Medicine, Northern Clinical School
Kolling Institute of Medical Research

Telephone +61 2 9926 4814
Fax +61 2 9926 6269

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Biographical details

Career summary

2014 – present: Professor of Repair and Regeneration in Medicine, University of Sydney

2006 – 2013: Associate Professor, Medicine, University of Sydney

1999 – present: Director, Sutton Arthritis Research Laboratory

1992: PhD University of Sydney

Research Support

· Four NHMRC grants (three as CIA) in past 6 years

· Health Research Council of New Zealand, Full Program grant, “Exploiting the therapeutic potential of viruses”, Investigators: A Mercer with 9 CIs incl. C Jackson, NZ$5 million awarded 26/06/13. A collaboration between researchers in New Zealand, USA and Australia. My role as CI is to provide expertise in pre-clinical and clinical trials in wound healing.

· JDRF International Innovative grant as CIA, 2009, US$102,000

· Korea National Research Foundation Project Grant “Role of APC in treatment of bisphosphonate-induced osteonecrosis of the jaw”, S Park, P Sambrook and C Jackson, 2010-13

· Ray and Pam Robinson award from Arthritis Australia in 2009 and 2013, $40,000 each

Contribution to field of research

The research of Prof Jackson and his team has evolved to become true bench to bedside. After making the original discovery, Dr Jackson has undertaken extensive basic laboratory studies, followed by animal studies to obtain proof-of-concept that APC heals chronic wounds. He then linked with his clinical colleagues to conduct open label human trials. With positive results he was awarded a NHMRC grant, as CIA, for a Phase II clinical trial, currently being conducted. He is now poised to reveal a novel contribution of APC in orthopaedic medicine.

Patents and Industry

· Granted patents: “A new skin wound healing agent” Inventors: C Jackson and P Sambrook. 2002302192 Australia 2007; 4351041 Japan 2009; EP 1 404 412 B1 Europe 2012; USA pending

o These patents are licensed to Bioatrix, a new start-up company incorporated in 2013 and currently seeking funding to undertake large clinical trials in dermatological conditions

· Dr Jackson is co-Founder of Bioatrix & Chair, Scientific Advisory Board which includes prominent medical researchers.

· PCT filed Nov 2013: “Treatment for inflammatory skin disorders” Inventors: C Jackson, M Xue

· PCT filed Feb 2014: “A treatment for bone defects”

Collaborations and Community engagement

· Regular Invited Speaker, at the Institute of Bone and Joint Public Forums (~200 members of public attending), Kolling Auditorium, Oct 2009, and Nov 2011. Topic “Rheumatoid Arthritis”

· Regular Invited Speaker at Ulysses Club functions. Topic “Arthritis Research”

Professional Involvement and International Standing - including invitations to speak, international committees

· Current Vice-President, Australasian Wound and Tissue Repair Society (AWTRS, 2012-2014)

· Member Organising Committee for 11 conferences incl. AWTRS Scientific meeting, Gold Coast, 2014

· Regular invited speaker at international conferences, including:

o Invited speaker, Int Soc Thrombosis Haemostasis meeting, Milwaukee, USA, June 2014

o Invited speaker and Session Organizer, Inaugural International session, Wound Healing Society, SAWC Spring Symp on Advanced Wound Care, Orlando, USA, April 2014

o Invited Speaker, 25th European Congress of Pathology, Lisbon, Portugal, July 2013

o Invited Speaker, Biopharmaceutical Summit-2013, Frankfurt, Germany, July 2013

o Speaker, International Vascular Biology Meeting, Weisbaden, Germany, July, 2012

o Invited speaker, Chair, Session Organiser, ANZMS, Margaret River, WA, Nov 2011

o Invited Speaker, Chair & Session Organiser, Int. Microcirculation Congress, Paris, Sept 2010

o Speaker, European Tissue Repair Society, Gent, Belgium, Aug 2010

o Invited speaker and Chair, ANZ Microcirculation Society, Queenstown, 2009

o Speaker and Chair, International Society Thrombosis and Hemostasis, Boston, USA 2009

· Current society memberships: Australian Rheumatology Association, Int. Soc. Thrombosis Haemostasis, AWTRS, ANZMS.

Supervision and mentoring

Has supervised 19 PhD students, 15 to graduation and 4 current and mentored 7 Early- and Mid-Career post-doctoral fellows.

Peer review involvement

· NHMRC Grant Review Panel member for project grants (2006, 2007, 2011)

· NHMRC Grant Review Panel for Early Career Fellowships (2009, 2013)

· Grant assessor include NHMRC (2-3 grants/year since 1997), Arthritis Australia (1 grant/year since 1996), Diabetes Aust. (1 grant/year since 2006), Israel Science Foundation (3 grants), JDRF Int. (2 grants), National Arthritis Spain (3 grants), Anti-Cancer Council of Victoria (3 grants)

· Editorial board of five peer-review journals

Research interests

Dr Jackson's research focuses on cellular and molecular mechanisms of inflammation in the fields of arthritis, diabetes and chronic skin disorders including burns and chronic wounds. We have a special interest in two groups of enzymes known as the matrix metalloproteinases and the serine proteases. Novel molecular biological techniques are used to manipulate cellular systems. Some interesting recent discoveries have come from our work investigating the mechanisms of action of one of these enzymes, activated protein C (APC). Our experiments using cultured cells and animal wounding models provide very strong evidence that APC accelerates wound healing. This work extends beyond cutaneous ulcers and has application to the healing of other tissues such as cartilage and bone that have been damaged by either disease, such as arthritis, or injury. Currently we are running 2 clinical trials to examine the efficacy of APC to treat chronic leg ulcers and burns. Two provisional patent applications for new therapeutic interventions have arisen from work performed in the Sutton laboratories.

International links

Canada

(to be declared) Prof David Hart is collaborating with us on the use of animal models for wound healing

Hong Kong S.A.R.

(Hong Kong Polytehnic, Prof Tony To) collaborative project on photoporphyrins and cancer

Japan

(Department of Immunology, Saga Medical School, Nabeshima, Saga, Japan) Prof Fukudome provides essential tools and advice for our research on wound healing, arthritis and diabetes.

Korea South

(College of Veterinary Medicine, Chonbuk National University, Jeonju) awarded a Korean Government grant and share 5 publications

United States

(Scripps, Prof John Griffin and Prof Charles Fisher) provision of unique therapeutic agent for collaborative project

Selected grants

2013

  • Can activated protein C reverse the aggressive properties of rheumatoid synoviocytes?; Xue M, Jackson C, March L, Tonkin M; Lincoln Centre for Research into Bone & Joint Diseases/Research Support.
  • DAMPENING THE AGGRESSIVE PROPERTIES OF RHEUMATOID SYNOVIAL FIBROBLASTS TO TREAT RHEUMATOID ARTHRITIS; Jackson C, Xue M; Arthritis Australia/Project Grants.

2012

  • Efficacy of Activated protein C to treat Diabetic Leg ulcers - a randomised, controlled clinical trial; Jackson C, Fulcher G, Wraight P, March L, Cooper A; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer; Baxter R, Halliday G, Marsh D, Gill A, Clarke S, Smith R, Little C, Jackson C, O'Neill C, Murphy C, Sharland A, Chadban S, Mason R, Assinder S, Verdurand M, Richardson D, Machaalani R, Hambly B, Chan-Ling T, Dos Remedios C, Holsinger D, Lay P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Differential contributions of protease activated receptor (PAR)1 and PAR2 in the aggressive properties of synovial fibroblasts in rheumatoid arthritis; Xue M, Jackson C, March L, Sambrook P, Laurent R; Royal North Shore Hospital/Staff Specialist Trust Fund.

2011

  • IncuCyte FLR Microscope System and Cell Incubator; Baxter R, Marsh D, Jackson C, O'Neill C, Ashton A, Howell V; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment.
  • IncuCyte FLR Microscope System (Essen Bioscience); Marsh D, Baxter R, Morris J, Jackson C, Howell V; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • Role of Activated protein C in treatment of bisphosphonate-induced diseases including osteonecrosis of the jaw; Jackson C, Park S, Sambrook P; Korean Research Foundation/Research Support.
  • How does activated protein C create intact, non-leaky, stable blood vessels?; Jackson C, Xue M; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • The regulatory role of APC on arthritis; Jackson C, Xue M, Sambrook P, March L; Arthritis Australia/Project Grants.
  • Novel pathways involving APC and PAR-2 in cartilage degradation in osteoarthritis; Little C, Jackson C; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • Activated protein C utilises protease activated receptors and epidermal growth factor receptor to heal wounds; Jackson C, Xue M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Safety and Efficacy of Activated protein C to treat Leg ulcers (SEAL)- a randonised, controlled clin; Jackson C; University of Sydney/Bridging Support.
  • Prevention of type 1 diabetes by activated protein C; Jackson C, Xue M, Fulcher G, Harrison L; Juvenile Diabetes Research Foundation/Research Grant.
  • Prevention of type 1 diabetes by activated protein C (APC); Jackson C; Juvenile Diabetes Research Foundation/Research Support.

2007

  • Effect of APC on pancreas; Fulcher G, Jackson C, Xue M; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.

2006

  • MT1-MMP is responsible for tendon invasion; Jackson C, Nanchahal J; University of Sydney/Bridging Support.

2005

  • Identification of adhesion molecules responsible for monocyte activation in diabetic women; Gallery E, Morris J, Jackson C, Xie L; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
  • Why is trophoblast invasion defective in pregnancies that develop pre-eclampsia?; Gallery E, Jackson C, Morris J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Interim Research Agreement (for Gap Funding); Quail D, Heathers G, Jackson C; Ucom Sixteen Pty Ltd /BLO Project.
  • The role of APC in the regulation of inflammation in RA; Xue M, Jackson C; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
  • Clinical Fellowship to support the salary of Dr Jackson; Jackson C; Lincoln Centre for Research into Bone & Joint Diseases/Post-Doctoral Fellowships.
  • The role of osteopontin in tenosynovitis; Le N, Nanchahal J, Jackson C; North Sydney Central Coast Area Health Services (NSCCAH)/Research Grant.
  • Hypoxia gene regulation system; Gallery E, Jackson C, Morris J; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Inverted Fluorescence Microscopy: A sensitive method used to visualise protein expression in live cells; Jackson C, Davey R, Little C, Morris J, Gallery E; BLO DETYA National School Drug Education Strategy/RIGB Grant.

2004

  • Monocyte-decidual endothelial interactions in diabetic pregnancies?; Jackson C, Gallery E, Morris J; Diabetes Australia/Research Grant.
  • Studies on the role of MT1-MMP in bone erosion; Nanchahal J, Jackson C; Rebecca L Cooper Medical Research Foundation/Research Grant.
  • Monitoring genes expression in vascular disease and wounds using real-time PCR; Jackson C; BLO DETYA National School Drug Education Strategy/RIGB Grant.
  • Understanding the mechanism of tendon invasion by tenosynovium in rheumatoid arthritis; Jackson C, Nanchahal J; Arthritis Foundation of Australia/Barbara Cameron Award.
  • Performance of research assays; Jackson C; Northern Sydney Area Health Service/Research Grants Scheme.

2003

  • A new treatment to promote wound healing; Jackson C, Cooper A, March L; National Health and Medical Research Council (NHMRC)/Development Grants.

2002

  • Interactions of human monocytes and decidual endothelial cells in the development of vascular disease in diabetic pregnancy; Jackson C, Gallery E, Campbell S, Morris J; MAWA Trust/Research Grant.
  • The use of a new agent to promote wound healing; Jackson C; University of Sydney/Vice Chancellor's Innovative Dev. Fund Seeding grant.
  • Abnormal interactions between peripheral blood monocytes and decidual endothelial cells in acute atherosis in human pregnancy; Gallery E, Morris J, Jackson C, Twigg S; Diabetes Australia/Research Grant.

2001

  • How is gelatinase B stored in endothelial cells; Jackson C, Nguyen M; Northern Sydney Area Health Service/Research Contract.
  • Effect of green tea phenols on rheumatoid arthritic synovial cells; Jackson C; Lincoln Centre for Research into Bone & Joint Diseases/Research Grant.

2000

  • The use of activated protein C to promote wound healing.; Hughes E, Pullen G, O'Donnell M, Eutick M, Jennings P, Stephens R, Crawford R, Grainger D, Jackson C, Wilkie S, Storey S, Little M, Woodward M, O'Kane S, Cantrell A, Colacino J; University of Sydney/Internal Research Grant Allocations - BLO.
  • The role of hyperglycaemia and hypoxia in mediating cytokine responses in diabetic nephropathy; Pollock C, Jackson C, Field M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Activated protein C and endothelial invasion; Jackson C; Northern Sydney Area Health Service/Research Contract.

Selected publications

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Book Chapters

  • Jackson, C., Xue, M. (2011). Anti-Inflammatory Actions of the Anticoagulant, Activated Protein C. In Amit Nagal (Eds.), Inflammatory Diseases - A Modern Perspective, (pp. 45-72). Rijeka: InTech Publishers.
  • Jackson, C., Schrieber, L. (2003). Angiogenesis in rheumatoid arthritis. In M C Hochberg, A J Silman, J S Smolen, M E Weinblatt, M H Weisman (Eds.), Rheumatology: Third Edition, (pp. 851-854). Edinburgh: Mosby.

Journals

  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research and Therapy, 16(1), R44. [More Information]
  • Jackson, M., Babak, M., Smith, M., Jackson, C., Little, C. (2014). Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 are activated by Activated Protein C (APC) in human osteoarthritic cartilage chondrocytes. Arthritis & Rheumatism, 66(6), 1525-1536. [More Information]
  • Lee, Y., Jeong, J., Seol, J., Xue, M., Jackson, C., Park, S. (2013). Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates. Experimental and Molecular Medicine, 45, 1-7. [More Information]
  • Julovi, S., Shen, K., McKelvey, K., Minhas, N., March, L., Jackson, C. (2013). Activated Protein C Inhibits Proliferation and Tumour Necrosis Factor alpha-stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts. Molecular Medicine, 19, 324-331. [More Information]
  • Akbari, M., Dadadashian, F., Kordestani, S., Xue, M., Jackson, C. (2013). Enzymatic modification of regenerated cellulosic fabrics to improve bacteria sorption properties. Journal of Biomedical Materials Research. Part A, 101A (6), 1734-1742. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]
  • Moon, M., Jeong, J., Lee, Y., Seol, J., Jackson, C., Park, S. (2013). SIRT1, a class III histone deacetylase, regulates TNF-alpha-induced inflammation in human chondrocytes. Osteoarthritis and Cartilage, 21(3), 470-480. [More Information]
  • Lee, Y., Jeong, J., Lee, J., Park, Y., Moon, J., Seol, J., Jackson, C., Park, S. (2013). Sphingosine-1-phosphate protects against bisphosphonate-induced HUVEC cell death via regulation of c-Jun-N-terminal kinase signaling. International Journal of Molecular Medicine, 31(4), 811-816. [More Information]
  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]
  • Xue, M., Dervish, S., Harrison, L., Fulcher, G., Jackson, C. (2012). Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice. Journal of Biological Chemistry, 287(20), 16356-16364. [More Information]
  • McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012). Potential anti-inflammatory treatments for chronic wounds. Wound Practice & Research, 20(2), 86-89.
  • Xue, M., Chan, A., Shen, K., Dervish, S., March, L., Sambrook, P., Jackson, C. (2012). Protease-Activated Receptor 2, Rather Than Protease-Activated Receptor 1, Contributes to the Aggressive Properties of Synovial Fibroblasts in Rheumatoid Arthritis. Arthritis & Rheumatism, 64(1), 88-98. [More Information]
  • Downey, A., Jackson, C., Harun, N., Cooper, A. (2012). Toxic epidermal necrolysis: Review of pathogenesis and management. Journal Of The American Academy Of Dermatology, 66(6), 995-1003. [More Information]
  • Xue, M., Chow, S., Dervish, S., Chan, Y., Julovi, S., Jackson, C. (2011). Activated Protein C Enhances Human Keratinocyte Barrier Integrity via Sequential Activation of Epidermal Growth Factor Receptor and Tie2. Journal of Biological Chemistry, 286(8), 6742-6750. [More Information]
  • Seol, J., Lee, Y., Jackson, C., Sambrook, P., Park, S. (2011). Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-KB pathways. International Journal of Molecular Medicine, 27(6), 835-840. [More Information]
  • Moon, M., Jeong, J., Seo, J., Seol, J., Lee, Y., Xue, M., Jackson, C., Park, S. (2011). Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation. Experimental and Molecular Medicine, 43(3), 138-145. [More Information]
  • Wijewardena, A., Vandervord, E., Lajevardi, S., Vandervord, J., Jackson, C. (2011). Combination of activated protein C and topical negative pressure rapidly regenerates granulation tissue over exposed bone to heal recalcitrant orthopedic wounds. The International Journal of Lower Extremity Wounds, 10(3), 146-151. [More Information]
  • Julovi, S., Ito, H., Nishitani, K., Jackson, C., Nakamura, T. (2011). Hyaluronan inhibits Matrix Metalloproteinase-13 in Human Arthritic Chondrocytes via CD44 and P38. Journal of Orthopaedic Research, 29(2), 258-264. [More Information]
  • Julovi, S., Xue, M., Dervish, S., Sambrook, P., March, L., Jackson, C. (2011). Protease Activated Receptor-2 Mediates Activated Protein C–Induced Cutaneous Wound Healing via Inhibition of p38. The American Journal of Pathology: cellular and molecular biology of disease, 179(5), 2233-2242. [More Information]
  • Minhas, N., Xue, M., Fukudome, K., Jackson, C. (2010). Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function. The F A S E B Journal, 24(3), 873-881. [More Information]
  • Nguyen, T., Little, C., Yenson, V., Jackson, C., McCracken, S., Warning, J., Stevens, V., Gallery, E., Morris, J. (2010). Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance. Journal of Autoimmunity, 35(1), 86-97. [More Information]
  • Xue, M., Minhas, N., Chow, S., Dervish, S., Sambrook, P., March, L., Jackson, C. (2010). Endogenous protein C is essential for the functional integrity of human endothelial cells. Cellular and Molecular Life Sciences, 67(9), 1537-1546. [More Information]
  • Hunyor, S., Jackson, C. (2010). Microenvironment and Macroenvironment in Hypertensive Hearts. Boundaries and Silos-Can We Pick and Treat Diastolic Heart Failure? Hypertension, 55(6), 1312-3. [More Information]
  • Moon, M., Seol, J., Seo, J., Jeong, J., Lee, Y., Kim, I., Jackson, C., Sambrook, P., Park, S. (2010). Protective effect of hypoxia on bisphosphonate-related bone cell damage. Molecular Medicine Reports, 3(5), 869-875.
  • Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009). Activated protein C mediates a healing phenotype in cultured tenocytes. Journal of Cellular and Molecular Medicine, 13(4), 749-757. [More Information]
  • Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009). Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthritis and Rheumatism, 60(3), 780-791. [More Information]
  • Xue, A., Xue, M., Jackson, C., Smith, R. (2009). Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling. The International Journal of Biochemistry and Cell Biology, 41(8-9), 1731-1738. [More Information]
  • Jackson, C., Xue, M. (2008). Activated protein C-An anticoagulant that does more than stop clots. The International Journal of Biochemistry and Cell Biology, 40(12), 2692-2697. [More Information]
  • Xue, M., Jackson, C. (2008). Autocrine Actions of Matrix Metalloproteinase (MMP)-2 Counter the Effects of MMP-9 to Promote Survival and Prevent Terminal Differentiation of Cultured Human Keratinocytes. The Journal of Investigative Dermatology, 128(11), 2676-2685. [More Information]
  • Jackson, C., Whitmont, K., Tritton, S., March, L., Sambrook, P., Xue, M. (2008). New therapeutic applications for the anticoagulant, activated protein C. Expert Opinion on Biological Therapy, 8(8), 1109-1122. [More Information]
  • Whitmont, K., Reid, I., Tritton, S., March, L., Xue, M., Lee, M., Fulcher, G., Sambrook, P., Slobedman, E., Cooper, A., Jackson, C. (2008). Treatment of chronic leg ulcers with topical activated protein C. Archives of Dermatology, 144(11), 1479-1483. [More Information]
  • Wang, Y., Chang, H., Wertheim, D., Jones, A., Jackson, C., Coombes, A. (2007). Characterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery. Biomaterials, 28(31), 4619-4627. [More Information]
  • Xue, M., March, L., Sambrook, P., Jackson, C. (2007). Differential Regulation of Matrix Metalloproteinase 2 and Matrix Metalloproteinase 9 by Activated Protein C: Relevance to Inflammation in Rheumatoid Arthritis. Arthritis and Rheumatism, 56(9), 2864-2874. [More Information]
  • Xue, M., March, L., Sambrook, P., Fukudome, K., Jackson, C. (2007). Endothelial protein C receptor is over-expressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Annals of the Rheumatic Diseases, 66(12), 1574-1580. [More Information]
  • Xie, L., Galettis, A., Morris, J., Jackson, C., Twigg, S., Gallery, E. (2007). Intercellular adhesion molecule-1 (ICAM-1) expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy. Diabetes - Metabolism: Research and Reviews, Online: 7 Nov 2007, 1-9. [More Information]
  • Gallagher, G., Jackson, C., Hunyor, S. (2007). Myocardial extracellular matrix remodelling in ischemic heart failure. Frontiers in Bioscience, 12(4), 1410-1419. [More Information]
  • Xue, M., Campbell, D., Jackson, C. (2007). Protein C is an autocrine growth factor for human skin keratinocytes. Journal of Biological Chemistry, 282(18), 13610-13616. [More Information]
  • Le, N., Xue, M., Castelnoble, L., Jackson, C. (2007). The dual personalities of matrix metalloproteinases in inflammation. Frontiers in Bioscience, 12, 1475-1487. [More Information]
  • Jackson, C., Xue, M. (2006). Activated protein C (APC) as a novel agent to promote wound healing. Primary Intention, 14(1), 31-34.
  • Xue, M., Thompson, P., Sambrook, P., March, L., Jackson, C. (2006). Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents. Clinical Hemorheology and Microcirculation, 34, 153-161. [More Information]
  • Au, C., Luk, S., Jackson, C., Ng, H., Yow, C., To, S. (2006). Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. Journal of Photochemistry and Photobiology B-Biology, 85(2), 92-101.
  • Gallagher, G., Menzie, S., Huang, Y., Jackson, C., Hunyor, S. (2006). Regional cardiac dysfunction is associated with specific alterations in inflammatory cytokines and matrix metalloproteinases after acute myocardial infarction in sheep. Basic Research in Cardiology. [More Information]
  • Xue, M., Jackson, C., Le, N. (2006). Targeting matrix metalloproteases to improve cutaneous wound healing. Expert Opinion on Therapeutic Targets, 10(1), 143-155. [More Information]
  • Jackson, C., Xue, M., Thompson, P., Davey, R., Whitmont, K., Smith, S., Buisson-Legendre, N., Sztynda, T., Furphy, L., Cooper, A., Sambrook, P., March, L. (2005). Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing. Wound Repair and Regeneration, 13(3), 284-294. [More Information]
  • Xue, M., Campbell, D., Sambrook, P., Fukudome, K., Jackson, C. (2005). Endothelial Protein C Receptor and Protease-Activated Receptor-1 Mediate Induction of a Wound-Healing Phenotype in Human Keratinocytes by Activated Protein C. The Journal of Investigative Dermatology, 125(6), 1279-1285. [More Information]
  • Xue, M., Thompson, P., Clifton-Bligh, R., Fulcher, G., Gallery, E., Jackson, C. (2005). Leukocyte matrix metalloproteinase-9 is elevated and contributes to lymphocyte activation in type I diabetes. The International Journal of Biochemistry and Cell Biology, 37(11), 2406-2416. [More Information]
  • Xue, M., Thompson, P., Kelso, I., Jackson, C. (2004). Activated Protein C Stimulates Proliferation, Migration And Wound Closure, Inhibits Apoptosis And Upregulates Mmp-2 Activity In Cultured Human Keratinocytes. Experimental Cell Research: emphasizing molecular approaches to cell biology, 299(1), 119-127.
  • Buisson-Legendre, N., Smith, S., March, L., Jackson, C. (2004). Elevation Of Activated Protein C In Synovial Joints In Rheumatoid Arthritis And Its Correlation With Matrix Metalloproteinase 2. Arthritis and Rheumatism, 50(7), 2151-2156. [More Information]
  • Field, M., Jackson, C., Pollock, C., Poronnik, P., Young, B., Qi, W. (2004). Human Cortical Fibroblast Responses To High Glucose And Hypoxia. Nephron Journals, Nephron Physiology: Volume 96(4), 121-129.
  • Campbell, S., Rowe, J., Jackson, C., Gallery, E. (2004). Interaction Of Cocultured Decidual Endothelial Cells And Cytotrophoblasts In Preeclampsia. Biology Of Reproduction, 71(1), 244-252.
  • Galettis, A., Campbell, S., Morris, J., Jackson, C., Twigg, S., Gallery, E. (2004). Monocyte adhesion to decidual endothelial cells is increased in pregnancies complicated by Type 1 diabetes but not by gestational diabetes. Diabetes Care, 27(10), 2514-2515.
  • Arkell, J., Jackson, C. (2003). Constitutive secretion of MMP9 by early-passage cultured human endothelial cells. Cell Biochemistry And Function, 21(4), 381-386. [More Information]
  • Campbell, S., Rowe, J., Jackson, C., Gallery, E. (2003). In vitro migration of cytotrophoblasts through a decidual endothelial cell monolayer: the role of matrix metalloproteinases. Placenta, 24(4), 306-315.
  • Jackson, C. (2002). Matrix metalloproteinases and angiogenesis. Current Opinion In Nephrology And Hypertension, 11(3), 295-299.
  • Gallery, E., Campbell, B., Ilkovski, B., Sinosich, M., Jackson, C. (2001). A novel in-vitro co-culture system for the study of maternal decidual endothelial cell-trophoblast interactions in human pregnancy. BJOG: an international journal of obstetrics and gynaecology, 108, 651-653.
  • Nguyen, M., Arkell, J., Jackson, C. (2001). Endothelial cells and gelatinases. The International Journal of Biochemistry and Cell Biology, 32, 621-631.
  • Jackson, C., Nguyen,, M., Arkell, J., Sambrook, P. (2001). Selective matrix metalloproteinase (MMP) inhibition in rheumatoid arthritis - targetting gelatinase A activation. Inflammation Research, 50, 183-186.

Conferences

  • Little, C., Jackson, M., Smith, M., Burkhardt, D., Xue, M., Jackson, C. (2006). Potential role of activated protein C (APC) in articular cartilage degeneration. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.

Patents

  • Sambrook, P., Jackson, C. (2009). Treatment And Composition For Wound Healing. Patent No. 2002302192, 4351041.

2014

  • Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research and Therapy, 16(1), R44. [More Information]
  • Jackson, M., Babak, M., Smith, M., Jackson, C., Little, C. (2014). Matrix metalloproteinase (MMP)-2, MMP-9 and MMP-13 are activated by Activated Protein C (APC) in human osteoarthritic cartilage chondrocytes. Arthritis & Rheumatism, 66(6), 1525-1536. [More Information]

2013

  • Lee, Y., Jeong, J., Seol, J., Xue, M., Jackson, C., Park, S. (2013). Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates. Experimental and Molecular Medicine, 45, 1-7. [More Information]
  • Julovi, S., Shen, K., McKelvey, K., Minhas, N., March, L., Jackson, C. (2013). Activated Protein C Inhibits Proliferation and Tumour Necrosis Factor alpha-stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts. Molecular Medicine, 19, 324-331. [More Information]
  • Akbari, M., Dadadashian, F., Kordestani, S., Xue, M., Jackson, C. (2013). Enzymatic modification of regenerated cellulosic fabrics to improve bacteria sorption properties. Journal of Biomedical Materials Research. Part A, 101A (6), 1734-1742. [More Information]
  • Whitmont, K., Fulcher, G., Reid, I., Xue, M., McKelvey, K., Xie, Y., Aboud, M., Ward, C., Smith, M., Cooper, A., March, L., Jackson, C. (2013). Low Circulating Protein C Levels Are Associated with Lower Leg Ulcers in Patients with Diabetes. BioMed Research International, 2013, 1-4. [More Information]
  • Moon, M., Jeong, J., Lee, Y., Seol, J., Jackson, C., Park, S. (2013). SIRT1, a class III histone deacetylase, regulates TNF-alpha-induced inflammation in human chondrocytes. Osteoarthritis and Cartilage, 21(3), 470-480. [More Information]
  • Lee, Y., Jeong, J., Lee, J., Park, Y., Moon, J., Seol, J., Jackson, C., Park, S. (2013). Sphingosine-1-phosphate protects against bisphosphonate-induced HUVEC cell death via regulation of c-Jun-N-terminal kinase signaling. International Journal of Molecular Medicine, 31(4), 811-816. [More Information]

2012

  • Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012). Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology, 159(3), 246-248. [More Information]
  • Xue, M., Dervish, S., Harrison, L., Fulcher, G., Jackson, C. (2012). Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice. Journal of Biological Chemistry, 287(20), 16356-16364. [More Information]
  • McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012). Potential anti-inflammatory treatments for chronic wounds. Wound Practice & Research, 20(2), 86-89.
  • Xue, M., Chan, A., Shen, K., Dervish, S., March, L., Sambrook, P., Jackson, C. (2012). Protease-Activated Receptor 2, Rather Than Protease-Activated Receptor 1, Contributes to the Aggressive Properties of Synovial Fibroblasts in Rheumatoid Arthritis. Arthritis & Rheumatism, 64(1), 88-98. [More Information]
  • Downey, A., Jackson, C., Harun, N., Cooper, A. (2012). Toxic epidermal necrolysis: Review of pathogenesis and management. Journal Of The American Academy Of Dermatology, 66(6), 995-1003. [More Information]

2011

  • Xue, M., Chow, S., Dervish, S., Chan, Y., Julovi, S., Jackson, C. (2011). Activated Protein C Enhances Human Keratinocyte Barrier Integrity via Sequential Activation of Epidermal Growth Factor Receptor and Tie2. Journal of Biological Chemistry, 286(8), 6742-6750. [More Information]
  • Seol, J., Lee, Y., Jackson, C., Sambrook, P., Park, S. (2011). Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-KB pathways. International Journal of Molecular Medicine, 27(6), 835-840. [More Information]
  • Jackson, C., Xue, M. (2011). Anti-Inflammatory Actions of the Anticoagulant, Activated Protein C. In Amit Nagal (Eds.), Inflammatory Diseases - A Modern Perspective, (pp. 45-72). Rijeka: InTech Publishers.
  • Moon, M., Jeong, J., Seo, J., Seol, J., Lee, Y., Xue, M., Jackson, C., Park, S. (2011). Bisphosphonate enhances TRAIL sensitivity to human osteosarcoma cells via death receptor 5 upregulation. Experimental and Molecular Medicine, 43(3), 138-145. [More Information]
  • Wijewardena, A., Vandervord, E., Lajevardi, S., Vandervord, J., Jackson, C. (2011). Combination of activated protein C and topical negative pressure rapidly regenerates granulation tissue over exposed bone to heal recalcitrant orthopedic wounds. The International Journal of Lower Extremity Wounds, 10(3), 146-151. [More Information]
  • Julovi, S., Ito, H., Nishitani, K., Jackson, C., Nakamura, T. (2011). Hyaluronan inhibits Matrix Metalloproteinase-13 in Human Arthritic Chondrocytes via CD44 and P38. Journal of Orthopaedic Research, 29(2), 258-264. [More Information]
  • Julovi, S., Xue, M., Dervish, S., Sambrook, P., March, L., Jackson, C. (2011). Protease Activated Receptor-2 Mediates Activated Protein C–Induced Cutaneous Wound Healing via Inhibition of p38. The American Journal of Pathology: cellular and molecular biology of disease, 179(5), 2233-2242. [More Information]

2010

  • Minhas, N., Xue, M., Fukudome, K., Jackson, C. (2010). Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function. The F A S E B Journal, 24(3), 873-881. [More Information]
  • Nguyen, T., Little, C., Yenson, V., Jackson, C., McCracken, S., Warning, J., Stevens, V., Gallery, E., Morris, J. (2010). Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance. Journal of Autoimmunity, 35(1), 86-97. [More Information]
  • Xue, M., Minhas, N., Chow, S., Dervish, S., Sambrook, P., March, L., Jackson, C. (2010). Endogenous protein C is essential for the functional integrity of human endothelial cells. Cellular and Molecular Life Sciences, 67(9), 1537-1546. [More Information]
  • Hunyor, S., Jackson, C. (2010). Microenvironment and Macroenvironment in Hypertensive Hearts. Boundaries and Silos-Can We Pick and Treat Diastolic Heart Failure? Hypertension, 55(6), 1312-3. [More Information]
  • Moon, M., Seol, J., Seo, J., Jeong, J., Lee, Y., Kim, I., Jackson, C., Sambrook, P., Park, S. (2010). Protective effect of hypoxia on bisphosphonate-related bone cell damage. Molecular Medicine Reports, 3(5), 869-875.

2009

  • Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009). Activated protein C mediates a healing phenotype in cultured tenocytes. Journal of Cellular and Molecular Medicine, 13(4), 749-757. [More Information]
  • Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009). Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthritis and Rheumatism, 60(3), 780-791. [More Information]
  • Xue, A., Xue, M., Jackson, C., Smith, R. (2009). Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling. The International Journal of Biochemistry and Cell Biology, 41(8-9), 1731-1738. [More Information]
  • Sambrook, P., Jackson, C. (2009). Treatment And Composition For Wound Healing. Patent No. 2002302192, 4351041.

2008

  • Jackson, C., Xue, M. (2008). Activated protein C-An anticoagulant that does more than stop clots. The International Journal of Biochemistry and Cell Biology, 40(12), 2692-2697. [More Information]
  • Xue, M., Jackson, C. (2008). Autocrine Actions of Matrix Metalloproteinase (MMP)-2 Counter the Effects of MMP-9 to Promote Survival and Prevent Terminal Differentiation of Cultured Human Keratinocytes. The Journal of Investigative Dermatology, 128(11), 2676-2685. [More Information]
  • Jackson, C., Whitmont, K., Tritton, S., March, L., Sambrook, P., Xue, M. (2008). New therapeutic applications for the anticoagulant, activated protein C. Expert Opinion on Biological Therapy, 8(8), 1109-1122. [More Information]
  • Whitmont, K., Reid, I., Tritton, S., March, L., Xue, M., Lee, M., Fulcher, G., Sambrook, P., Slobedman, E., Cooper, A., Jackson, C. (2008). Treatment of chronic leg ulcers with topical activated protein C. Archives of Dermatology, 144(11), 1479-1483. [More Information]

2007

  • Wang, Y., Chang, H., Wertheim, D., Jones, A., Jackson, C., Coombes, A. (2007). Characterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery. Biomaterials, 28(31), 4619-4627. [More Information]
  • Xue, M., March, L., Sambrook, P., Jackson, C. (2007). Differential Regulation of Matrix Metalloproteinase 2 and Matrix Metalloproteinase 9 by Activated Protein C: Relevance to Inflammation in Rheumatoid Arthritis. Arthritis and Rheumatism, 56(9), 2864-2874. [More Information]
  • Xue, M., March, L., Sambrook, P., Fukudome, K., Jackson, C. (2007). Endothelial protein C receptor is over-expressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Annals of the Rheumatic Diseases, 66(12), 1574-1580. [More Information]
  • Xie, L., Galettis, A., Morris, J., Jackson, C., Twigg, S., Gallery, E. (2007). Intercellular adhesion molecule-1 (ICAM-1) expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy. Diabetes - Metabolism: Research and Reviews, Online: 7 Nov 2007, 1-9. [More Information]
  • Gallagher, G., Jackson, C., Hunyor, S. (2007). Myocardial extracellular matrix remodelling in ischemic heart failure. Frontiers in Bioscience, 12(4), 1410-1419. [More Information]
  • Xue, M., Campbell, D., Jackson, C. (2007). Protein C is an autocrine growth factor for human skin keratinocytes. Journal of Biological Chemistry, 282(18), 13610-13616. [More Information]
  • Le, N., Xue, M., Castelnoble, L., Jackson, C. (2007). The dual personalities of matrix metalloproteinases in inflammation. Frontiers in Bioscience, 12, 1475-1487. [More Information]

2006

  • Jackson, C., Xue, M. (2006). Activated protein C (APC) as a novel agent to promote wound healing. Primary Intention, 14(1), 31-34.
  • Xue, M., Thompson, P., Sambrook, P., March, L., Jackson, C. (2006). Activated protein C stimulates expression of angiogenic factors in human skin cells, angiogenesis in the chick embryo and cutaneous wound healing in rodents. Clinical Hemorheology and Microcirculation, 34, 153-161. [More Information]
  • Au, C., Luk, S., Jackson, C., Ng, H., Yow, C., To, S. (2006). Differential effects of photofrin, 5-aminolevulinic acid and calphostin C on glioma cells. Journal of Photochemistry and Photobiology B-Biology, 85(2), 92-101.
  • Little, C., Jackson, M., Smith, M., Burkhardt, D., Xue, M., Jackson, C. (2006). Potential role of activated protein C (APC) in articular cartilage degeneration. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
  • Gallagher, G., Menzie, S., Huang, Y., Jackson, C., Hunyor, S. (2006). Regional cardiac dysfunction is associated with specific alterations in inflammatory cytokines and matrix metalloproteinases after acute myocardial infarction in sheep. Basic Research in Cardiology. [More Information]
  • Xue, M., Jackson, C., Le, N. (2006). Targeting matrix metalloproteases to improve cutaneous wound healing. Expert Opinion on Therapeutic Targets, 10(1), 143-155. [More Information]

2005

  • Jackson, C., Xue, M., Thompson, P., Davey, R., Whitmont, K., Smith, S., Buisson-Legendre, N., Sztynda, T., Furphy, L., Cooper, A., Sambrook, P., March, L. (2005). Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing. Wound Repair and Regeneration, 13(3), 284-294. [More Information]
  • Xue, M., Campbell, D., Sambrook, P., Fukudome, K., Jackson, C. (2005). Endothelial Protein C Receptor and Protease-Activated Receptor-1 Mediate Induction of a Wound-Healing Phenotype in Human Keratinocytes by Activated Protein C. The Journal of Investigative Dermatology, 125(6), 1279-1285. [More Information]
  • Xue, M., Thompson, P., Clifton-Bligh, R., Fulcher, G., Gallery, E., Jackson, C. (2005). Leukocyte matrix metalloproteinase-9 is elevated and contributes to lymphocyte activation in type I diabetes. The International Journal of Biochemistry and Cell Biology, 37(11), 2406-2416. [More Information]

2004

  • Xue, M., Thompson, P., Kelso, I., Jackson, C. (2004). Activated Protein C Stimulates Proliferation, Migration And Wound Closure, Inhibits Apoptosis And Upregulates Mmp-2 Activity In Cultured Human Keratinocytes. Experimental Cell Research: emphasizing molecular approaches to cell biology, 299(1), 119-127.
  • Buisson-Legendre, N., Smith, S., March, L., Jackson, C. (2004). Elevation Of Activated Protein C In Synovial Joints In Rheumatoid Arthritis And Its Correlation With Matrix Metalloproteinase 2. Arthritis and Rheumatism, 50(7), 2151-2156. [More Information]
  • Field, M., Jackson, C., Pollock, C., Poronnik, P., Young, B., Qi, W. (2004). Human Cortical Fibroblast Responses To High Glucose And Hypoxia. Nephron Journals, Nephron Physiology: Volume 96(4), 121-129.
  • Campbell, S., Rowe, J., Jackson, C., Gallery, E. (2004). Interaction Of Cocultured Decidual Endothelial Cells And Cytotrophoblasts In Preeclampsia. Biology Of Reproduction, 71(1), 244-252.
  • Galettis, A., Campbell, S., Morris, J., Jackson, C., Twigg, S., Gallery, E. (2004). Monocyte adhesion to decidual endothelial cells is increased in pregnancies complicated by Type 1 diabetes but not by gestational diabetes. Diabetes Care, 27(10), 2514-2515.

2003

  • Jackson, C., Schrieber, L. (2003). Angiogenesis in rheumatoid arthritis. In M C Hochberg, A J Silman, J S Smolen, M E Weinblatt, M H Weisman (Eds.), Rheumatology: Third Edition, (pp. 851-854). Edinburgh: Mosby.
  • Arkell, J., Jackson, C. (2003). Constitutive secretion of MMP9 by early-passage cultured human endothelial cells. Cell Biochemistry And Function, 21(4), 381-386. [More Information]
  • Campbell, S., Rowe, J., Jackson, C., Gallery, E. (2003). In vitro migration of cytotrophoblasts through a decidual endothelial cell monolayer: the role of matrix metalloproteinases. Placenta, 24(4), 306-315.

2002

  • Jackson, C. (2002). Matrix metalloproteinases and angiogenesis. Current Opinion In Nephrology And Hypertension, 11(3), 295-299.

2001

  • Gallery, E., Campbell, B., Ilkovski, B., Sinosich, M., Jackson, C. (2001). A novel in-vitro co-culture system for the study of maternal decidual endothelial cell-trophoblast interactions in human pregnancy. BJOG: an international journal of obstetrics and gynaecology, 108, 651-653.
  • Nguyen, M., Arkell, J., Jackson, C. (2001). Endothelial cells and gelatinases. The International Journal of Biochemistry and Cell Biology, 32, 621-631.
  • Jackson, C., Nguyen,, M., Arkell, J., Sambrook, P. (2001). Selective matrix metalloproteinase (MMP) inhibition in rheumatoid arthritis - targetting gelatinase A activation. Inflammation Research, 50, 183-186.

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