Professor Christine Clarke

Professorial Research Fellow
Medicine, Westmead Clinical School
Westmead Millennium Institute for Medical Research

Telephone +61 2 9845 9068
Fax +61 2 9845 9102

Map

Selected grants

2015

  • Hormone receptor distribution in a model of the human breast; Hovey R, Clarke C; DVC Research/International Research Collaboration Award (IRCA).

2014

  • NanoString nCounter Platform; deFazio A, Alexander I, Booth D, Byrne J, Christodoulou J, Clarke C, Cunningham A, George J, Graham J, Harman A, Liddle C, Mann G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Steroid hormone action in normal and malignant breast; Clarke C; DVC Research/Bridging Support Grant.

2013

  • Chromatin context of progesterone transcriptional activity in normal and cancer cells; Clarke C, Graham J; Worldwide Cancer Research/Research Support.
  • Determinants of genomic binding of the progesterone receptor in endocrine target cells; Clarke C, Graham J; Cancer Council New South Wales/Research Project Grants.

2012

  • Data collection and management for the Australian Breast Cancer Tissue Bank; Clarke C; Cancer Institute New South Wales/Research Infrastructure Grant.
  • Data Linkage for NSW Bioresources using CHeReL; Baxter R, Robinson B, Boyle F, Clarke C, Marsh D; Cancer Institute New South Wales/Biobanking Stakeholder Network Funding.
  • Maximising support for breast cancer research by the Australian Breast Cancer Tissue Bank; Clarke C, Marsh D, Forbes J, Scott R, Dahlstrom J, Zeps N, Simpson P; National Breast Cancer Foundation/Infrastructure Grant.
  • Alignment of Australian breast and ovarian bioresources, to enhance research and improve outcomes for breast and ovarian cancer; Clarke C; National Breast Cancer Foundation/Think Tank Program.

2011

  • High Speed Cell Sorter for Flow Cytometry Core Facility; Clarke C; Cancer Institute New South Wales/Equipment Grant.
  • The BD Influx High Speed Cell Sorter; Cunningham A, George J, Rizos H, Clarke C, Reddel R, Kefford R, North K, Stewart G, Jones C, Tam P, Alexander S, Gottlieb D, Bradstock K, Bryan T, Booth D, Bendall L, Brilot-Turville F, Hebbard L, Cooper S, Wang Y, Wang X; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Progesterone regulation of epithelial expansion in the normal human breast; Clarke C, Graham J; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Investigating the role of microRNAs in breast cancer progression; Soon P, Balleine R, Clarke C, Pathmanathan N; National Breast Cancer Foundation/Pilot Study Grants.
  • Facilities for cryogenic storage and transport of tissue bank materials; Clarke C, Baxter R, Lee C, Marsh D; Cancer Institute New South Wales/Equipment Grant.
  • GenomeLab GeXP Genetic Analysis System for the Multi-Disciplinary Sydney Cancer Gene Expression Facility; Richardson D, Halliday G, Scolyer R, Clarke S, Lee C, Reichardt J, Clarke C, Murray M, Boyer M, Kefford R; Cancer Institute New South Wales/Equipment Grant.
  • NHMRC Principal Research Fellowship; Clarke C; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.
  • The BD Influx High Speed Cell Sorter; Kefford R, Cunningham A, Bendall L, Clarke C, Harris D, Alexander S, Tam P, Sorrell T, Iredell J, Bryan T, Rizos H, Wang Y, Hebbard L; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Westmead Correlative Light and Electron Microscope Suite; North K, Jones C, Christodoulou J, Murray R, O'Neill G, Cantrill L, Cunningham A, Kefford R, Clarke C, Henderson B, Bendall L, Turville S, Reddel R, Tam P, Robinson P, Bryan T, Braithwaite A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Breast cancer biospecimen resource; Morey A, Forbes J, Scott R, Spigelman A, Clarke C, Kefford R, Baxter R, Marsh D, Friedlander M, Harnett P, Balleine R, Bilous M, Boyages J, Sutherland R; National Health and Medical Research Council (NHMRC)/Enabling Grants.

2009

  • Breast Cancer Tissue Bank - data collection and management infrasture; Clarke C, Scott R, Balleine R, Carpenter J, Baxter R, Bilous M, Lee S, Marsh D, Scott R, Spigelman A; Cancer Institute New South Wales/Infrastructure Grant.
  • Progesterone signalling in normal and malignant breast relies on chromosomal positioning of progesterone receptor; Clarke C, Graham J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • High-Throughput virtual microscopy and data warehouse system; Mann G, Schifter M, Balleine R, George J, Henderson B, Clarke C, Catchpoole D, deFazio A; Cancer Institute New South Wales/Equipment Grant.
  • Deltavision (DV) Core Image Restoration; Cunningham A, Turville S, Clarke C, Henderson B, Kefford R, North K, O'Neill G, Murray R, Reddel R, Tam P, Robinson P, Chircop M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Progesterone regulation of epithelial cell lineages in the breast; Clarke C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Identification of nuclear receptor networks as new targets for breast cancer treatment; Clarke C, Tilley W, Leedman P, Muscat G, Fuller P, Funder J, Ragan M, Simpson E, Rosenthal N; National Breast Cancer Foundation/Collaborative Breast Cancer Research Program.
  • Med Oncology W/Mead-Clar; Clarke C; Western Sydney Local Health District/Research Support.

2007

  • Breast cancer biospecimen resource; Kefford R, Balleine R, Baxter R, Clarke C, Bilous M; National Breast Cancer Foundation/Facilitation Grant.
  • Breast Cancer Tissue Bank; Marsh D, Clarke C, Scott R, Kefford R, Balleine R, Baxter R, Bilous M, Carpenter J, Friedlander M, Forbes J, Boyages J, Spigelman A, Sutherland R, Harnett P, Morey A; National Breast Cancer Foundation/Research Grants.
  • Tracing the origin of variable malignant potential in breast cancer; Balleine R, Clarke C; University of Sydney/Cancer Research Fund.

2006

  • Impact of progesterone receptor submuclear localisation on progesterone action in endocrine target cells; Clarke C, Graham J; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • Research Fellowship PRF - Clarke; Clarke C; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.
  • Breast Cancer biospecimen resource; Boyages J, Spigelman A, Forbes J, Marsh D, Friedlander M, Morey A, Spigelman A, Sutherland R, Scott R, Balleine R, Baxter R, Bilous M, Kefford R, Clarke C; National Breast Cancer Foundation/Grant-in-Aid.
  • Top-up grant (NHMRC Enabling ); Clarke C; National Breast Cancer Foundation/Facilitation Grant.
  • Breast cancer biospecimen resource; Marsh D, Clarke C, Harnett P, Spigelman A, Forbes J, Harnett P, Friedlander M, Sutherland R, Boyages J, Morey A, Spigelman A, Scott R, Balleine R, Baxter R, Bilous M, Kefford R; Cancer Institute New South Wales/Research Grant.
  • Cell architectural determinants of transcriptional disruption in breast cancer; Clarke C, Graham J; National Breast Cancer Foundation/Concept Awards.
  • Progesterone receptor action in the normal human breast; Clarke C, Mote P; National Health and Medical Research Council (NHMRC)/Project Grants.

2004

  • Progestin regulation of gene expression pathways in human breast cancer; Clarke C; University of Sydney/Cancer Research Fund.
  • Breast cancer biospecimen resource; Clarke C, Balleine R, Bilous M, Kefford R, Baxter R, Harnett P, Spigelman A, Forbes J, Spigelman A, Marsh D, Boyages J, Friedlander M, Harnett P, Morey A, Scott R, Sutherland R; National Health and Medical Research Council (NHMRC)/Enabling Grants.
  • Zeiss axiovert 200M cell observer system; Henderson B, Cunningham A, Farrell G, Clarke C, Diefenbach R, Kefford R, Rizos H; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2003

  • Progestin regulation of gene expression pathways in human breast cancer; Graham J, Clarke C; Cure Cancer Australia Foundation/Research Support.
  • PALM MicroBeam laser system with flourescent upgrade; North K, Clarke C, Cunningham A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2002

  • Modulation of cytoskeletal structure by progesterone receptor isoforms; Clarke C, Weinberger R; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Hormonal regulation of cytoskeletal proteins affects cell morphology in breast cancer cells; Clarke C, Weinberger R; Leo and Jenny Leukaemia and Cancer Foundation/Leukaemia and Cancer Foundation.
  • Expression and function of progesterone and oestrogen receptors in human breast cancer; Clarke C; National Health and Medical Research Council (NHMRC)/Project Grants.

2000

  • Significance and mechanisms of relative progesterone receptor isoform expression in normal and malignant target tissues; Clarke C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Early events predisposing to breast cancer in women with a genetic susceptibility; Clarke C, Leary J, Balleine R, Kirk J; Leo and Jenny Leukaemia and Cancer Foundation/Leukaemia and Cancer Foundation.
  • Transgenomic WAVE 2100 denaturing HPLC system for DNA variant analysis; Farrell G, Clarke C, Cunningham A, deFazio A, Kirk J, Leary J, Liddle C, Manolios N, Mitchell P, Stewart G, Mann G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Physiological role of progesterone receptors in normal and malignant target tissues; Clarke C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanisms underlying the protective effects of tamoxifen on normal mammary gland; deFazio A, Clarke C; Cancer Council New South Wales/Research Project Grants.

Selected publications

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Book Chapters

  • Hilton, H., Graham, J., Clarke, C. (2012). Estrogen and Progestin Stimulation of Breast Proliferation. In R. Paul Robinson (Eds.), Translational Endocrinology & Metabolism: Breast Cancer Update, (pp. 1-28). Maryland, United States: The Endocrine Society.

Journals

  • Khushi, M., Liddle, C., Clarke, C., Graham, J. (2014). Binding Sites Analyser (BiSA): Software for Genomic Binding Sites Archiving and Overlap Analysis. PLoS One, 9(2), 1-12. [More Information]
  • Hilton, H., Santucci, N., Silvestri, A., Kantimm, S., Huschtscha, L., Graham, J., Clarke, C. (2014). Progesterone stimulates progenitor cells in normal human breast and breast cancer cells. Breast Cancer Research and Treatment, 143(3), 423-433. [More Information]
  • Hilton, H., Kantimm, S., Graham, J., Clarke, C. (2013). Changed lineage composition is an early event in breast carcinogenesis. Histology and histopathology, 28(9), 1197-1204. [More Information]
  • Knower, K., Chand, A., Eriksson, N., Takagi, K., Miki, Y., Sasano, H., Visvader, J., Lindeman, G., Funder, J., Fuller, P., Graham, J., Clarke, C., et al (2013). Distinct nuclear receptor expression in stroma adjacent to breast tumors. Breast Cancer Research and Treatment, 142(1), 211-223. [More Information]
  • Khushi, M., Edwards, G., de Marcos, D., Carpenter, J., Graham, J., Clarke, C. (2013). Open source tools for management and archiving of digital microscopy data to allow integration with patient pathology and treatment information. Diagnostic Pathology, 8(1), 1-7. [More Information]
  • Webster, L., Provan, P., Graham, J., Byth Wilson, K., Walker, R., Davis, S., Salisbury, E., Morey, A., Ward, R., Hawkins, N., Clarke, C., Balleine, R., et al (2013). Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33. Pathology, 45(7), 629-636. [More Information]
  • Muscat, G., Eriksson, N., Byth Wilson, K., Loi, S., Graham, D., Jindal, S., Davis, M., Clyne, C., Funder, J., Simpson, E., Kuczek, E., Clarke, C., et al (2013). Research Resource: Nuclear Receptors as Transcriptome: Discriminant and Prognostic Value in Breast Cancer. Molecular Endocrinology, 27(2), 350-365. [More Information]
  • Khushi, M., Carpenter, J., Balleine, R., Clarke, C. (2012). Development of a data entry auditing protocol and quality assurance for a tissue bank database. Cell and Tissue Banking, 13(1), 9-13. [More Information]
  • Khushi, M., Carpenter, J., Balleine, R., Clarke, C. (2012). Electronic Biorepository Application System: Web-Based Software to Manage Receipt, Peer Review, and Approval of Researcher Applications. Biopreservation and Biobanking, 10(1), 37-44. [More Information]
  • Clarke, C., Graham, J. (2012). Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes. PLoS One, 7(4), 1-14. [More Information]
  • Graham, J., Clarke, C. (2012). Preview: MCE special issue on molecular mechanisms of action in progesterone signalling. Molecular And Cellular Endocrinology, 357(1/2), 1-3. [More Information]
  • Hilton, H., Graham, J., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, L., Mote, P., Clarke, C. (2012). Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast. Molecular And Cellular Endocrinology, 361(1-2), 191-201. [More Information]
  • Dowhan, D., Harrison, M., Eriksson, N., Bailey, P., Pearen, M., Fuller, P., Funder, J., Simpson, E., Leedman, P., Tilley, W., Clarke, C., et al (2012). Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes. Endocrine-Related Cancer, 19(4), 509-526. [More Information]
  • Haiman, C., Chen, G., Vachon, C., Canzian, F., Dunning, A., Millikan, R., Wang, X., Ademuyiwa, F., Ahmed, S., Ambrosone, C., Balleine, R., Carpenter, J., Clarke, C., et al (2011). A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer. Nature Genetics, 43(12), 1210-1215. [More Information]
  • Stevens, K., Vachon, C., Lee, A., Slager, S., Lesnick, T., Oswald, C., fasching, P., Miron, P., Carpenter, J., Clarke, C., Balleine, R., et al (2011). Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer. Cancer Research, 71(19), 6240-6249. [More Information]
  • Emmanuel, C., Gava, N., Kennedy, C., Balleine, R., Sharma, R., Wain, G., Brand, A., Hogg, R., Etemadmoghadam, D., George, J., Clarke, C., Harnett, P., deFazio, A., et al (2011). Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis. PLoS One, 6(3), e17617-1-e17617-18. [More Information]
  • Pathmanathan, N., Salisbury, E., Provan, P., Bilous, M., Byth Wilson, K., Milliken, J., Clarke, C., Balleine, R. (2010). A class discovery and class prediction approach to histopathological classification of mammographic screen detected columnar cell lesions of the breast. Pathology, 42(1), 28-36. [More Information]
  • Joshi, P., Jackson, H., Beristain, A., Di Grappa, M., Mote, P., Clarke, C., Stingl, J., Khokha, R., Waterhouse, P. (2010). Progesterone induces adult mammary stem cell expansion. Nature, 465(7299), 803-807. [More Information]
  • Hilton, H., Kalyuga, M., Cowley, M., Alles, M., Lee, H., Caldon, C., Blazek, K., Kaplan, W., Musgrove, E., Daly, R., Graham, J., Clarke, C., et al (2010). The Antiproliferative Effects of Progestins in T47D Breast Cancer Cells Are Tempered by Progestin Induction of the ETS Transcription Factor Elf5. Molecular Endocrinology, 24(7), 1380-1392. [More Information]
  • Graham, J., Mote, P., Salagame, U., Van Dijk, J., Balleine, R., Huschtscha-Holliday, L., Reddel, R., Clarke, C. (2009). DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology, 150(7), 3318-3326. [More Information]
  • Graham, J., Mote, P., Salagame, U., Balleine, R., Huschtscha-Holliday, L., Clarke, C. (2009). Hormone-Responsive Model of Primary Human Breast Epithelium. Journal of Mammary Gland Biology and Neoplasia, 14(4), 367-379. [More Information]
  • Graham, J., Hanson, A., Croft, A., Fox, A., Clarke, C. (2009). Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci. The F A S E B Journal, 23(doi: 10.1096/fj.08-113639), 546-556. [More Information]
  • Scarpin, K., Graham, J., Mote, P., Clarke, C. (2009). Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression. Nuclear Receptor Signaling, 7(10.1621/nrs.07009), e009 - 1-e009 - 13. [More Information]
  • Cops, E., Bianco-Miotto, T., Moore, N., Clarke, C., Birrell, S., Butler, L., Tilley, W. (2008). Antiproliferative actions of the synthetic androgen, mibolerone, in breast cancer cells are mediated by both androgen and progesterone receptors. Journal of Steroid Biochemistry and Molecular Biology, 110(3-5), 236-243. [More Information]
  • Gava, N., Clarke, C., Bye, C., Byth Wilson, K., deFazio, A. (2008). Global gene expression profiles of ovarian surface epithelial cells in vivo. Journal of Molecular Endocrinology, 40, 281-296. [More Information]
  • Balleine, R., Webster, L., Davis, S., Salisbury, E., Palazzo, J., Schwartz, G., Cornfield, D., Walker, R., Byth Wilson, K., Clarke, C., et al (2008). Molecular Grading of Ductal Carcinoma In situ of the Breast. Clinical Cancer Research, 14(24), 8244-8252. [More Information]
  • Webster, L., Lee, S., Ringland, C., Morey, A., Hanby, A., Morgan, G., Byth Wilson, K., Mote, P., Provan, P., Ellis, I., Lamoury, G., Clarke, C., Balleine, R., et al (2008). Poor-prognosis estrogen receptor-positive breast cancer identified by histopathologic subclassification. Clinical Cancer Research, 14(20), 6625-6633. [More Information]
  • Gurney, H., Wong, M., Balleine, R., Rivory, L., McLachlan, A., Hoskins, J., Wilcken, N., Clarke, C., Mann, G., Collins, M., et al (2007). Imatinib Disposition and ABCB1 (MDR1, P-Glycoprotein) Genotype. Pharmacology and Therapeutics, 82(1), 33-40. [More Information]
  • Mote, P., Graham, J., Clarke, C. (2007). Progesterone receptor isoforms in normal and malignant breast. Ernst Schering Research Foundation Workshop, (1), 77-107. [More Information]
  • Mann, G., Thorne, H., Balleine, R., Butow, P., Clarke, C., Edkins, E., Evans, G., Fereday, S., Haan, E., Gattas, M., Kirk, J., Leary, J., Pupo, G., et al (2006). Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource. Breast Cancer Research, 8(1), 1-15. [More Information]
  • Arnett-Mansfield, R., Graham, J., Hanson, A., Mote, P., Gompel, A., Scurr, L., Gava, N., deFazio, A., Clarke, C. (2006). Focal subnuclear distribution of progesterone receptor is ligand-dependent and associated with transcriptional activity. Molecular Endocrinology, 21(1), 14-29. [More Information]
  • Mote, P., Arnett-Mansfield, R., Gava, N., deFazio, A., Mulac-Jericevic, B., Conneely, O., Clarke, C. (2006). Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Endocrinology, 147(12), 5503-5512. [More Information]
  • WONG, M., Balleine, R., Blair, E., McLachlan, A., Ackland, S., Garg, M., Evans, S., Farlow, D., Collins, M., Rivory, L., Hoskins, J., Mann, G., Clarke, C., Gurney, H. (2006). Predictors of Vinorelbine Pharmacokinetics and Pharmacodynamics in Patients With Cancer. Journal of Clinical Oncology, 24(16), 2448-2455.
  • Cowell, L., Graham, J., Bouton, A., Clarke, C., O'Neill, G. (2006). Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway. Oncogene, 25(58), 7597-7607. [More Information]
  • Graham, J., Yager, M., Hill, H., Byth Wilson, K., O'Neill, G., Clarke, C. (2005). Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells. Molecular Endocrinology, 19(11), 2713-2735. [More Information]
  • Aghmesheh, M., Edwards, L., Clarke, C., Byth Wilson, K., Katzenellenbogen, B., Russell, P., Friedlander, M., Tucker, K., deFazio, A. (2005). Expression of steroid hormone receptors in BRCA1-associated ovarian carcinomas. Gynecologic Oncology, 97(1), 16-25. [More Information]
  • Wong, M., Evans, S., Rivory, L., Hoskins, J., Mann, G., Farlow, D., Clarke, C., Balleine, R., Gurney, H. (2005). Hepatic technetium Tc 99m-labeled sestamibi elimination rate and ABCB1 (MDR1) genotype as indicators of ABCB1 (P-glycoprotein) activity in patients with cancer. Pharmacology and Therapeutics, 77(1). [More Information]
  • Webster, L., Bilous, M., Willis, L., Byth Wilson, K., Burgemeister, F., Salisbury, E., Clarke, C., Balleine, R. (2005). Histopathologic indicators of breast cancer biology: insights from population mammographic screening. British Journal of Cancer, 92(8), 1366-1371. [More Information]
  • van den Heuvel, M., Chantakru, S., Xie, X., Evans, S., Tekpetey, F., Mote, P., Clarke, C., Croy, B. (2005). Trafficking of Circulating Pro-NK Cells to the Decidualizing Uterus: Regulatory Mechanisms in the Mouse and Human. Immunological Investigations, 34(3), 273-293. [More Information]
  • Wong, M., Balleine, R., Collins, M., Liddle, C., Clarke, C., Gurney, H. (2004). Cyp3A5 Genotype And Midazolam Clearance In Australian Patients Receiving Chemotherapy. Pharmacology and Therapeutics, 75(6), 529-538. [More Information]
  • McGowan, E., Saad, S., Bendall, L., Bradstock, K., Clarke, C. (2004). Effect Of Progesterone Receptor A Predominance On Breast Cancer Cell Migration Into Bone Marrow Fibroblasts. Breast Cancer Research and Treatment, 83(3), 211-220.
  • Balleine, R., Earls, P., Webster, L., Mote, P., deFazio, A., Harnett, P., Clarke, C. (2004). Expression Of Progesterone Receptor A And B Isoforms In Low-Grade Endometrial Stromal Sarcoma. International Journal of Gynecological Pathology, 23(2), 138-144.
  • Gava, N., Clarke, C., Byth Wilson, K., Arnett-Mansfield, R., deFazio, A. (2004). Expression Of Progesterone Receptors A And B In The Mouse Ovary During The Estrous Cycle. Endocrinology, 145(7), 3487-3494.
  • Mote, P., Leary, J., Avery, K., Sandelin, K., Chenevix-Trench, G., kConFab Investigators., Kirk, J., Clarke, C. (2004). Germ-Line Mutations In Brca1 Or Brca2 In The Normal Breast Are Associated With Altered Expression Of Estrogen-Responsive Proteins And The Predominance Of Progesterone Receptor A. Genes Chromosomes and Cancer, 39(3), 236-248. [More Information]
  • Arnett-Mansfield, R., deFazio, A., Mote, P., Clarke, C. (2004). Subnuclear Distribution Of Progesterone Receptors A And B In Normal And Malignant Endometrium. Journal of Clinical Endocrinology and Metabolism, 89(3), 1429-1442.
  • McGowan, E., Weinberger, R., Graham, J., Hill, H., Hughes, J., O'Neill, G., Clarke, C. (2003). Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels. Journal of Molecular Endocrinology, 31(2), 241-253.
  • Kennedy, C., Byth, K., Clarke, C., deFazio, A. (2002). Cell proliferation in the normal mouse mammary gland and inhibition by phenylbutyrate. Molecular Cancer Therapeutics, 1(12), 1025-1033.
  • Mote, P., Bartow, S., Tran, N., Clarke, C. (2002). Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcinogenesis. Breast Cancer Research and Treatment, 72(2), 163-172.
  • Graham, J., Clarke, C. (2002). Progesterone receptors - animal models and cell signaling in breast cancer: expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells. Breast Cancer Research, 4(5), 187-190.
  • Mote, P., Clarke, C., Johnston, J., Manninen, T., Tuohimaa, P. (2001). Detection of progesterone receptor forms A and B by immunohistochemical analysis. Journal of Clinical Pathology, 54, 624-630.
  • Tilley, W., Clarke, C., Birrell, S., Bruchovsky, N. (2001). Hormones and Cancer: new insights, new challenges. Trends in Endocrinology and Metabolism, 12(5), 186-188.
  • Arnett-Mansfield, R., Wain, G., Jaworski, R., Mote, P., Clarke, C., deFazio, A., Byth, K. (2001). Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium1. Cancer Research, 61, 4576-4582.
  • Balleine, R., Humphrey, K., Clarke, C. (2001). Tumour banks: providing human tissue for cancer research. Medical Journal of Australia, 175, 293-294.
  • Mote, P., Balleine, R., McGowan, E., Clarke, C. (2000). Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma. Human Reproduction, 15(supp3), 48-56.
  • Davis, T., Kennedy, C., Chiew, Y., Clarke, C., deFazio, A. (2000). Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells. Clinical Cancer Research, 6(11), 4334-4342.
  • Balleine, R., Schoenberg Fejzo, M., Sathasivam, P., Basset, P., Clarke, C., Byrne, J. (2000). The hD52 (TDP52) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma. Genes Chromosomes and Cancer, 29(1), 48-57.

Conferences

  • Carpenter, J., Clarke, C. (2006). Twenty-first century tissue banking: Lessons from the past are shaping the future - Breast Cancer Tissue Bank, Australia. ISBER 2006 7th Annual Meeting "The Repository of the Future", United States: Mary Ann Liebert Inc. Publishers.

2014

  • Khushi, M., Liddle, C., Clarke, C., Graham, J. (2014). Binding Sites Analyser (BiSA): Software for Genomic Binding Sites Archiving and Overlap Analysis. PLoS One, 9(2), 1-12. [More Information]
  • Hilton, H., Santucci, N., Silvestri, A., Kantimm, S., Huschtscha, L., Graham, J., Clarke, C. (2014). Progesterone stimulates progenitor cells in normal human breast and breast cancer cells. Breast Cancer Research and Treatment, 143(3), 423-433. [More Information]

2013

  • Hilton, H., Kantimm, S., Graham, J., Clarke, C. (2013). Changed lineage composition is an early event in breast carcinogenesis. Histology and histopathology, 28(9), 1197-1204. [More Information]
  • Knower, K., Chand, A., Eriksson, N., Takagi, K., Miki, Y., Sasano, H., Visvader, J., Lindeman, G., Funder, J., Fuller, P., Graham, J., Clarke, C., et al (2013). Distinct nuclear receptor expression in stroma adjacent to breast tumors. Breast Cancer Research and Treatment, 142(1), 211-223. [More Information]
  • Khushi, M., Edwards, G., de Marcos, D., Carpenter, J., Graham, J., Clarke, C. (2013). Open source tools for management and archiving of digital microscopy data to allow integration with patient pathology and treatment information. Diagnostic Pathology, 8(1), 1-7. [More Information]
  • Webster, L., Provan, P., Graham, J., Byth Wilson, K., Walker, R., Davis, S., Salisbury, E., Morey, A., Ward, R., Hawkins, N., Clarke, C., Balleine, R., et al (2013). Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33. Pathology, 45(7), 629-636. [More Information]
  • Muscat, G., Eriksson, N., Byth Wilson, K., Loi, S., Graham, D., Jindal, S., Davis, M., Clyne, C., Funder, J., Simpson, E., Kuczek, E., Clarke, C., et al (2013). Research Resource: Nuclear Receptors as Transcriptome: Discriminant and Prognostic Value in Breast Cancer. Molecular Endocrinology, 27(2), 350-365. [More Information]

2012

  • Khushi, M., Carpenter, J., Balleine, R., Clarke, C. (2012). Development of a data entry auditing protocol and quality assurance for a tissue bank database. Cell and Tissue Banking, 13(1), 9-13. [More Information]
  • Khushi, M., Carpenter, J., Balleine, R., Clarke, C. (2012). Electronic Biorepository Application System: Web-Based Software to Manage Receipt, Peer Review, and Approval of Researcher Applications. Biopreservation and Biobanking, 10(1), 37-44. [More Information]
  • Hilton, H., Graham, J., Clarke, C. (2012). Estrogen and Progestin Stimulation of Breast Proliferation. In R. Paul Robinson (Eds.), Translational Endocrinology & Metabolism: Breast Cancer Update, (pp. 1-28). Maryland, United States: The Endocrine Society.
  • Clarke, C., Graham, J. (2012). Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes. PLoS One, 7(4), 1-14. [More Information]
  • Graham, J., Clarke, C. (2012). Preview: MCE special issue on molecular mechanisms of action in progesterone signalling. Molecular And Cellular Endocrinology, 357(1/2), 1-3. [More Information]
  • Hilton, H., Graham, J., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, L., Mote, P., Clarke, C. (2012). Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast. Molecular And Cellular Endocrinology, 361(1-2), 191-201. [More Information]
  • Dowhan, D., Harrison, M., Eriksson, N., Bailey, P., Pearen, M., Fuller, P., Funder, J., Simpson, E., Leedman, P., Tilley, W., Clarke, C., et al (2012). Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes. Endocrine-Related Cancer, 19(4), 509-526. [More Information]

2011

  • Haiman, C., Chen, G., Vachon, C., Canzian, F., Dunning, A., Millikan, R., Wang, X., Ademuyiwa, F., Ahmed, S., Ambrosone, C., Balleine, R., Carpenter, J., Clarke, C., et al (2011). A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer. Nature Genetics, 43(12), 1210-1215. [More Information]
  • Stevens, K., Vachon, C., Lee, A., Slager, S., Lesnick, T., Oswald, C., fasching, P., Miron, P., Carpenter, J., Clarke, C., Balleine, R., et al (2011). Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer. Cancer Research, 71(19), 6240-6249. [More Information]
  • Emmanuel, C., Gava, N., Kennedy, C., Balleine, R., Sharma, R., Wain, G., Brand, A., Hogg, R., Etemadmoghadam, D., George, J., Clarke, C., Harnett, P., deFazio, A., et al (2011). Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis. PLoS One, 6(3), e17617-1-e17617-18. [More Information]

2010

  • Pathmanathan, N., Salisbury, E., Provan, P., Bilous, M., Byth Wilson, K., Milliken, J., Clarke, C., Balleine, R. (2010). A class discovery and class prediction approach to histopathological classification of mammographic screen detected columnar cell lesions of the breast. Pathology, 42(1), 28-36. [More Information]
  • Joshi, P., Jackson, H., Beristain, A., Di Grappa, M., Mote, P., Clarke, C., Stingl, J., Khokha, R., Waterhouse, P. (2010). Progesterone induces adult mammary stem cell expansion. Nature, 465(7299), 803-807. [More Information]
  • Hilton, H., Kalyuga, M., Cowley, M., Alles, M., Lee, H., Caldon, C., Blazek, K., Kaplan, W., Musgrove, E., Daly, R., Graham, J., Clarke, C., et al (2010). The Antiproliferative Effects of Progestins in T47D Breast Cancer Cells Are Tempered by Progestin Induction of the ETS Transcription Factor Elf5. Molecular Endocrinology, 24(7), 1380-1392. [More Information]

2009

  • Graham, J., Mote, P., Salagame, U., Van Dijk, J., Balleine, R., Huschtscha-Holliday, L., Reddel, R., Clarke, C. (2009). DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology, 150(7), 3318-3326. [More Information]
  • Graham, J., Mote, P., Salagame, U., Balleine, R., Huschtscha-Holliday, L., Clarke, C. (2009). Hormone-Responsive Model of Primary Human Breast Epithelium. Journal of Mammary Gland Biology and Neoplasia, 14(4), 367-379. [More Information]
  • Graham, J., Hanson, A., Croft, A., Fox, A., Clarke, C. (2009). Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci. The F A S E B Journal, 23(doi: 10.1096/fj.08-113639), 546-556. [More Information]
  • Scarpin, K., Graham, J., Mote, P., Clarke, C. (2009). Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression. Nuclear Receptor Signaling, 7(10.1621/nrs.07009), e009 - 1-e009 - 13. [More Information]

2008

  • Cops, E., Bianco-Miotto, T., Moore, N., Clarke, C., Birrell, S., Butler, L., Tilley, W. (2008). Antiproliferative actions of the synthetic androgen, mibolerone, in breast cancer cells are mediated by both androgen and progesterone receptors. Journal of Steroid Biochemistry and Molecular Biology, 110(3-5), 236-243. [More Information]
  • Gava, N., Clarke, C., Bye, C., Byth Wilson, K., deFazio, A. (2008). Global gene expression profiles of ovarian surface epithelial cells in vivo. Journal of Molecular Endocrinology, 40, 281-296. [More Information]
  • Balleine, R., Webster, L., Davis, S., Salisbury, E., Palazzo, J., Schwartz, G., Cornfield, D., Walker, R., Byth Wilson, K., Clarke, C., et al (2008). Molecular Grading of Ductal Carcinoma In situ of the Breast. Clinical Cancer Research, 14(24), 8244-8252. [More Information]
  • Webster, L., Lee, S., Ringland, C., Morey, A., Hanby, A., Morgan, G., Byth Wilson, K., Mote, P., Provan, P., Ellis, I., Lamoury, G., Clarke, C., Balleine, R., et al (2008). Poor-prognosis estrogen receptor-positive breast cancer identified by histopathologic subclassification. Clinical Cancer Research, 14(20), 6625-6633. [More Information]

2007

  • Gurney, H., Wong, M., Balleine, R., Rivory, L., McLachlan, A., Hoskins, J., Wilcken, N., Clarke, C., Mann, G., Collins, M., et al (2007). Imatinib Disposition and ABCB1 (MDR1, P-Glycoprotein) Genotype. Pharmacology and Therapeutics, 82(1), 33-40. [More Information]
  • Mote, P., Graham, J., Clarke, C. (2007). Progesterone receptor isoforms in normal and malignant breast. Ernst Schering Research Foundation Workshop, (1), 77-107. [More Information]

2006

  • Mann, G., Thorne, H., Balleine, R., Butow, P., Clarke, C., Edkins, E., Evans, G., Fereday, S., Haan, E., Gattas, M., Kirk, J., Leary, J., Pupo, G., et al (2006). Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource. Breast Cancer Research, 8(1), 1-15. [More Information]
  • Arnett-Mansfield, R., Graham, J., Hanson, A., Mote, P., Gompel, A., Scurr, L., Gava, N., deFazio, A., Clarke, C. (2006). Focal subnuclear distribution of progesterone receptor is ligand-dependent and associated with transcriptional activity. Molecular Endocrinology, 21(1), 14-29. [More Information]
  • Mote, P., Arnett-Mansfield, R., Gava, N., deFazio, A., Mulac-Jericevic, B., Conneely, O., Clarke, C. (2006). Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Endocrinology, 147(12), 5503-5512. [More Information]
  • WONG, M., Balleine, R., Blair, E., McLachlan, A., Ackland, S., Garg, M., Evans, S., Farlow, D., Collins, M., Rivory, L., Hoskins, J., Mann, G., Clarke, C., Gurney, H. (2006). Predictors of Vinorelbine Pharmacokinetics and Pharmacodynamics in Patients With Cancer. Journal of Clinical Oncology, 24(16), 2448-2455.
  • Cowell, L., Graham, J., Bouton, A., Clarke, C., O'Neill, G. (2006). Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway. Oncogene, 25(58), 7597-7607. [More Information]
  • Carpenter, J., Clarke, C. (2006). Twenty-first century tissue banking: Lessons from the past are shaping the future - Breast Cancer Tissue Bank, Australia. ISBER 2006 7th Annual Meeting "The Repository of the Future", United States: Mary Ann Liebert Inc. Publishers.

2005

  • Graham, J., Yager, M., Hill, H., Byth Wilson, K., O'Neill, G., Clarke, C. (2005). Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells. Molecular Endocrinology, 19(11), 2713-2735. [More Information]
  • Aghmesheh, M., Edwards, L., Clarke, C., Byth Wilson, K., Katzenellenbogen, B., Russell, P., Friedlander, M., Tucker, K., deFazio, A. (2005). Expression of steroid hormone receptors in BRCA1-associated ovarian carcinomas. Gynecologic Oncology, 97(1), 16-25. [More Information]
  • Wong, M., Evans, S., Rivory, L., Hoskins, J., Mann, G., Farlow, D., Clarke, C., Balleine, R., Gurney, H. (2005). Hepatic technetium Tc 99m-labeled sestamibi elimination rate and ABCB1 (MDR1) genotype as indicators of ABCB1 (P-glycoprotein) activity in patients with cancer. Pharmacology and Therapeutics, 77(1). [More Information]
  • Webster, L., Bilous, M., Willis, L., Byth Wilson, K., Burgemeister, F., Salisbury, E., Clarke, C., Balleine, R. (2005). Histopathologic indicators of breast cancer biology: insights from population mammographic screening. British Journal of Cancer, 92(8), 1366-1371. [More Information]
  • van den Heuvel, M., Chantakru, S., Xie, X., Evans, S., Tekpetey, F., Mote, P., Clarke, C., Croy, B. (2005). Trafficking of Circulating Pro-NK Cells to the Decidualizing Uterus: Regulatory Mechanisms in the Mouse and Human. Immunological Investigations, 34(3), 273-293. [More Information]

2004

  • Wong, M., Balleine, R., Collins, M., Liddle, C., Clarke, C., Gurney, H. (2004). Cyp3A5 Genotype And Midazolam Clearance In Australian Patients Receiving Chemotherapy. Pharmacology and Therapeutics, 75(6), 529-538. [More Information]
  • McGowan, E., Saad, S., Bendall, L., Bradstock, K., Clarke, C. (2004). Effect Of Progesterone Receptor A Predominance On Breast Cancer Cell Migration Into Bone Marrow Fibroblasts. Breast Cancer Research and Treatment, 83(3), 211-220.
  • Balleine, R., Earls, P., Webster, L., Mote, P., deFazio, A., Harnett, P., Clarke, C. (2004). Expression Of Progesterone Receptor A And B Isoforms In Low-Grade Endometrial Stromal Sarcoma. International Journal of Gynecological Pathology, 23(2), 138-144.
  • Gava, N., Clarke, C., Byth Wilson, K., Arnett-Mansfield, R., deFazio, A. (2004). Expression Of Progesterone Receptors A And B In The Mouse Ovary During The Estrous Cycle. Endocrinology, 145(7), 3487-3494.
  • Mote, P., Leary, J., Avery, K., Sandelin, K., Chenevix-Trench, G., kConFab Investigators., Kirk, J., Clarke, C. (2004). Germ-Line Mutations In Brca1 Or Brca2 In The Normal Breast Are Associated With Altered Expression Of Estrogen-Responsive Proteins And The Predominance Of Progesterone Receptor A. Genes Chromosomes and Cancer, 39(3), 236-248. [More Information]
  • Arnett-Mansfield, R., deFazio, A., Mote, P., Clarke, C. (2004). Subnuclear Distribution Of Progesterone Receptors A And B In Normal And Malignant Endometrium. Journal of Clinical Endocrinology and Metabolism, 89(3), 1429-1442.

2003

  • McGowan, E., Weinberger, R., Graham, J., Hill, H., Hughes, J., O'Neill, G., Clarke, C. (2003). Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels. Journal of Molecular Endocrinology, 31(2), 241-253.

2002

  • Kennedy, C., Byth, K., Clarke, C., deFazio, A. (2002). Cell proliferation in the normal mouse mammary gland and inhibition by phenylbutyrate. Molecular Cancer Therapeutics, 1(12), 1025-1033.
  • Mote, P., Bartow, S., Tran, N., Clarke, C. (2002). Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcinogenesis. Breast Cancer Research and Treatment, 72(2), 163-172.
  • Graham, J., Clarke, C. (2002). Progesterone receptors - animal models and cell signaling in breast cancer: expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells. Breast Cancer Research, 4(5), 187-190.

2001

  • Mote, P., Clarke, C., Johnston, J., Manninen, T., Tuohimaa, P. (2001). Detection of progesterone receptor forms A and B by immunohistochemical analysis. Journal of Clinical Pathology, 54, 624-630.
  • Tilley, W., Clarke, C., Birrell, S., Bruchovsky, N. (2001). Hormones and Cancer: new insights, new challenges. Trends in Endocrinology and Metabolism, 12(5), 186-188.
  • Arnett-Mansfield, R., Wain, G., Jaworski, R., Mote, P., Clarke, C., deFazio, A., Byth, K. (2001). Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium1. Cancer Research, 61, 4576-4582.
  • Balleine, R., Humphrey, K., Clarke, C. (2001). Tumour banks: providing human tissue for cancer research. Medical Journal of Australia, 175, 293-294.

2000

  • Mote, P., Balleine, R., McGowan, E., Clarke, C. (2000). Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma. Human Reproduction, 15(supp3), 48-56.
  • Davis, T., Kennedy, C., Chiew, Y., Clarke, C., deFazio, A. (2000). Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells. Clinical Cancer Research, 6(11), 4334-4342.
  • Balleine, R., Schoenberg Fejzo, M., Sathasivam, P., Basset, P., Clarke, C., Byrne, J. (2000). The hD52 (TDP52) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma. Genes Chromosomes and Cancer, 29(1), 48-57.

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