Professor Christine Clarke

Professorial Research Fellow
Medicine, Westmead Clinical School
The Westmead Institute for Medical Research

Telephone +61 2 8627 3701
Fax +61 2 8627 3799

Map

Selected grants

2016

  • Nanozoomer Fluorescence Module; Clarke C, Mann G, Gunton J; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Extending the strategic importance of the Australian Breast Cancer Tissue Bank to facilitate breast cancer research; Scott R, Balleine R, Clarke C, Dahlstrom J, Forbes J, Marsh D, Pathmanathan N, Simpson P, Yip D, Zeps N; National Breast Cancer Foundation/Infrastructure Grant.
  • A pilot study to develop novel targeted treatments and personalized tests for triple negative breast cancer; Graham J, Dinh P, Clarke C, Harnett P, Pathmanathan N; National Breast Cancer Foundation/Pilot Study Grants.

2015

  • Collecting and managing data: a key component of the Australian Breast Cancer Tissue Bank support of translational research; Clarke C; Cancer Institute New South Wales/Research Infrastructure Grant.
  • Hormone receptor distribution in a model of the human breast; Hovey R, Clarke C; DVC Research/International Research Collaboration Award (IRCA).
  • Determining sleep phenotypes in cancer cohorts: interactions with cancer biology and impacts on quality of life; Kairaitis K, Amis T, Wheatley J, deFazio A, Wain G, Clarke C, Elder E, Dhillon H, Marshall N; DVC Research/SPARC Implementation - Cancer.
  • Covaris Evolution Adaptive Focused Acoustic Ultrasonicator for enhancement of cancer research within the Sydney West Hub; Graham J, Clarke C, Mann G, deFazio A, George J, Liddle C, Booth D, Sintchenko V; Cancer Institute New South Wales/Equipment Grant.
  • Scoping of a collaborative process and system to manage returned research results for NSW cancer biobanks; Clarke C; Cancer Institute New South Wales/Biobanking Stakeholder Network Funding.
  • Hormone action in the normal breast; Clarke C; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.
  • Role of progesterone in normal breast and its convergence with estrogen action in breast cancer; Clarke C, Ormandy C, Graham J, Hilton H; Cancer Council New South Wales/Research Project Grants.

2014

  • Semi-automatic Tissue Microarrayer with digital image integration for enhancement of cancer research within the Sydney West Hub; Clarke C, Carpenter J, Mann G, DeFazio A, George J, Pathmanathan N, Byrne J, Graham D; Cancer Institute New South Wales/Equipment Grant.
  • NanoString nCounter Platform; deFazio A, Alexander I, Booth D, Byrne J, Christodoulou J, Clarke C, Cunningham A, George J, Graham J, Harman A, Liddle C, Mann G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Steroid hormone action in normal and malignant breast; Clarke C; DVC Research/Bridging Support Grant.

2013

  • Chromatin context of progesterone transcriptional activity in normal and cancer cells; Clarke C, Graham J; Worldwide Cancer Research/Research Support.
  • Determinants of genomic binding of the progesterone receptor in endocrine target cells; Clarke C, Graham J; Cancer Council New South Wales/Research Project Grants.

2012

  • Data collection and management for the Australian Breast Cancer Tissue Bank; Clarke C; Cancer Institute New South Wales/Research Infrastructure Grant.
  • Maximising support for breast cancer research by the Australian Breast Cancer Tissue Bank; Clarke C, Marsh D, Forbes J, Scott R, Dahlstrom J, Zeps N, Simpson P; National Breast Cancer Foundation/Infrastructure Grant.
  • Data Linkage for NSW Bioresources using CHeReL; Baxter R, Robinson B, Boyle F, Clarke C, Marsh D; Cancer Institute New South Wales/Biobanking Stakeholder Network Funding.
  • Alignment of Australian breast and ovarian bioresources, to enhance research and improve outcomes for breast and ovarian cancer; Clarke C; National Breast Cancer Foundation/Think Tank Program.

2011

  • High Speed Cell Sorter for Flow Cytometry Core Facility; Clarke C; Cancer Institute New South Wales/Equipment Grant.
  • The BD Influx High Speed Cell Sorter; Cunningham A, George J, Rizos H, Clarke C, Reddel R, Kefford R, North K, Stewart G, Jones C, Tam P, Alexander S, Gottlieb D, Bradstock K, Bryan T, Booth D, Bendall L, Brilot-Turville F, Hebbard L, Cooper S, Wang Y, Wang X; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Progesterone regulation of epithelial expansion in the normal human breast; Clarke C, Graham J; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Facilities for cryogenic storage and transport of tissue bank materials; Clarke C, Baxter R, Lee C, Marsh D; Cancer Institute New South Wales/Equipment Grant.
  • GenomeLab GeXP Genetic Analysis System for the Multi-Disciplinary Sydney Cancer Gene Expression Facility; Richardson D, Halliday G, Scolyer R, Clarke S, Lee C, Reichardt J, Clarke C, Murray M, Boyer M, Kefford R; Cancer Institute New South Wales/Equipment Grant.
  • Investigating the role of microRNAs in breast cancer progression; Soon P, Balleine R, Clarke C, Pathmanathan N; National Breast Cancer Foundation/Pilot Study Grants.
  • Westmead Correlative Light and Electron Microscope Suite; North K, Jones C, Christodoulou J, Murray R, O'Neill G, Cantrill L, Cunningham A, Kefford R, Clarke C, Henderson B, Bendall L, Turville S, Reddel R, Tam P, Robinson P, Bryan T, Braithwaite A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • NHMRC Principal Research Fellowship; Clarke C; National Health and Medical Research Council (NHMRC)/Career Awards: Research Fellowships.
  • Breast cancer biospecimen resource; Morey A, Forbes J, Scott R, Spigelman A, Clarke C, Kefford R, Baxter R, Marsh D, Friedlander M, Harnett P, Balleine R, Bilous M, Boyages J, Sutherland R; National Health and Medical Research Council (NHMRC)/Enabling Grants.
  • The BD Influx High Speed Cell Sorter; Kefford R, Cunningham A, Bendall L, Clarke C, Harris D, Alexander S, Tam P, Sorrell T, Iredell J, Bryan T, Rizos H, Wang Y, Hebbard L; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Breast Cancer Tissue Bank - data collection and management infrasture; Clarke C, Scott R, Balleine R, Carpenter J, Baxter R, Bilous M, Lee S, Marsh D, Scott R, Spigelman A; Cancer Institute New South Wales/Infrastructure Grant.
  • Deltavision (DV) Core Image Restoration; Cunningham A, Turville S, Clarke C, Henderson B, Kefford R, North K, O'Neill G, Murray R, Reddel R, Tam P, Robinson P, Chircop M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • High-Throughput virtual microscopy and data warehouse system; Mann G, Schifter M, Balleine R, George J, Henderson B, Clarke C, Catchpoole D, deFazio A; Cancer Institute New South Wales/Equipment Grant.
  • Progesterone signalling in normal and malignant breast relies on chromosomal positioning of progesterone receptor; Clarke C, Graham J; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • Med Oncology W/Mead-Clar; Clarke C; Western Sydney Local Health District/Research Support.
  • Identification of nuclear receptor networks as new targets for breast cancer treatment; Clarke C, Tilley W, Leedman P, Muscat G, Fuller P, Funder J, Ragan M, Simpson E, Rosenthal N; National Breast Cancer Foundation/National Collaborative Breast Cancer Research Grant Program.
  • Progesterone regulation of epithelial cell lineages in the breast; Clarke C; National Health and Medical Research Council (NHMRC)/Project Grants.

2007

  • Breast Cancer Tissue Bank; Marsh D, Clarke C, Scott R, Kefford R, Balleine R, Baxter R, Bilous M, Carpenter J, Friedlander M, Forbes J, Boyages J, Spigelman A, Sutherland R, Harnett P, Morey A; National Breast Cancer Foundation/Research Grant.
  • Tracing the origin of variable malignant potential in breast cancer; Balleine R, Clarke C; University of Sydney/Cancer Research Fund.
  • Breast cancer biospecimen resource; Kefford R, Balleine R, Baxter R, Clarke C, Bilous M; National Breast Cancer Foundation/Facilitation Grant.

2006

  • Impact of progesterone receptor submuclear localisation on progesterone action in endocrine target cells; Clarke C, Graham J; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • Breast Cancer biospecimen resource; Boyages J, Spigelman A, Forbes J, Marsh D, Friedlander M, Morey A, Spigelman A, Sutherland R, Scott R, Balleine R, Baxter R, Bilous M, Kefford R, Clarke C; National Breast Cancer Foundation/Grant-in-Aid.
  • Progesterone receptor action in the normal human breast; Clarke C, Mote P; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Breast cancer biospecimen resource; Marsh D, Clarke C, Harnett P, Spigelman A, Forbes J, Harnett P, Friedlander M, Sutherland R, Boyages J, Morey A, Spigelman A, Scott R, Balleine R, Baxter R, Bilous M, Kefford R; Cancer Institute New South Wales/Research Grant.
  • Cell architectural determinants of transcriptional disruption in breast cancer; Clarke C, Graham J; National Breast Cancer Foundation/Concept Awards.
  • Top-up grant (NHMRC Enabling ); Clarke C; National Breast Cancer Foundation/Facilitation Grant.
  • Research Fellowship PRF - Clarke; Clarke C; National Health and Medical Research Council (NHMRC)/Established Career Fellowships.

2004

  • Zeiss axiovert 200M cell observer system; Henderson B, Cunningham A, Farrell G, Clarke C, Diefenbach R, Kefford R, Rizos H; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Progestin regulation of gene expression pathways in human breast cancer; Clarke C; University of Sydney/Cancer Research Fund.
  • Breast cancer biospecimen resource; Clarke C, Balleine R, Bilous M, Kefford R, Baxter R, Harnett P, Spigelman A, Forbes J, Spigelman A, Marsh D, Boyages J, Friedlander M, Harnett P, Morey A, Scott R, Sutherland R; National Health and Medical Research Council (NHMRC)/Enabling Grants.

2003

  • PALM MicroBeam laser system with flourescent upgrade; North K, Clarke C, Cunningham A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Progestin regulation of gene expression pathways in human breast cancer; Graham J, Clarke C; Cure Cancer Australia Foundation/Research Support.

2002

  • Modulation of cytoskeletal structure by progesterone receptor isoforms; Clarke C, Weinberger R; National Health and Medical Research Council (NHMRC)/Project Grants.

2001

  • Hormonal regulation of cytoskeletal proteins affects cell morphology in breast cancer cells; Clarke C, Weinberger R; Leo and Jenny Leukaemia and Cancer Foundation/Leukaemia and Cancer Foundation.
  • Expression and function of progesterone and oestrogen receptors in human breast cancer; Clarke C; National Health and Medical Research Council (NHMRC)/Project Grants.

2000

  • Physiological role of progesterone receptors in normal and malignant target tissues; Clarke C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Mechanisms underlying the protective effects of tamoxifen on normal mammary gland; deFazio A, Clarke C; Cancer Council New South Wales/Research Project Grants.
  • Transgenomic WAVE 2100 denaturing HPLC system for DNA variant analysis; Farrell G, Clarke C, Cunningham A, deFazio A, Kirk J, Leary J, Liddle C, Manolios N, Mitchell P, Stewart G, Mann G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Early events predisposing to breast cancer in women with a genetic susceptibility; Clarke C, Leary J, Balleine R, Kirk J; Leo and Jenny Leukaemia and Cancer Foundation/Leukaemia and Cancer Foundation.
  • Significance and mechanisms of relative progesterone receptor isoform expression in normal and malignant target tissues; Clarke C; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Hilton, H., Graham, J., Clarke, C. (2012). Estrogen and Progestin Stimulation of Breast Proliferation. In R. Paul Robinson (Eds.), Translational Endocrinology & Metabolism: Breast Cancer Update, (pp. 1-28). Maryland, United States: The Endocrine Society.

Journals

  • Purrington, K., Visscher, D., Wang, C., Yannoukakos, D., Hamann, U., Nevanlinna, H., Cox, A., Giles, G., Eckel-Passow, J., Clarke, C., Carpenter, J., et al (2016). Genes associated with histopathologic features of triple negative breast tumors predict molecular subtypes. Breast Cancer Research and Treatment, 157(1), 117-131. [More Information]
  • Zeng, C., Guo, X., Long, J., Kuchenbaecker, K., Droit, A., Michailidou, K., Ghoussaini, M., Kar, S., Freeman, A., Carpenter, J., Clarke, C., et al (2016). Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. Breast Cancer Research, 18(1), 1-21. [More Information]
  • Southey, M., Goldgar, D., Winqvist, R., Pylkas, K., Couch, F., Tischkowitz, M., Foulkes, W., Dennis, J., Michailidou, K., et al, Carpenter, J., Clarke, C. (2016). PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS. Journal of Medical Genetics, tba(tba), tba-tba. [More Information]
  • Oh, T., Wang, S., Acharya, B., Goode, J., Graham, J., Clarke, C., Yap, A., Muscat, G. (2016). The Nuclear Receptor, ROR(gamma), Regulates Pathways Necessary for Breast Cancer Metastasis. EBioMedicine, 6, 59-72. [More Information]
  • Bonneterre, J., Hutt, E., Bosq, J., Graham, J., Powell, M., Leblanc, E., Fujiwara, K., Herzog, T., Coleman, R., Clarke, C., et al (2015). Development of a technique to detect the activated form of the progesterone receptor and correlation with clinical and histopathological characteristics of endometrioid adenocarcinoma of the uterine corpus. Gynecologic Oncology, 138(3), 663-667. [More Information]
  • Hilton, H., Clarke, C. (2015). Impact of Progesterone on Stem/Progenitor Cells in the Human Breast. Journal of Mammary Gland Biology and Neoplasia, 20(1-2), 27-37. [More Information]
  • Hilton, H., Graham, J., Clarke, C. (2015). Minireview: Progesterone Regulation of Proliferation in the Normal Human Breast and in Breast Cancer: A Tale of Two Scenarios? Molecular Endocrinology, 29(9), 1230-1242. [More Information]
  • Mavaddat, N., Pharoah, P., Michailidou, K., Tyrer, J., Book, M., Bolla, M., Wang, Q., Dennis, J., Dunning, A., Shah, M., Balleine, R., Carpenter, J., Clarke, C., et al (2015). Prediction of breast cancer risk based on profiling with common genetic variants. Journal of the National Cancer Institute, 107(5), 1-15. [More Information]
  • Clarke, C., Dontu, G., Hilton, H., Meier-Abt, F., Sartorius, C. (2015). Preface. Journal of Mammary Gland Biology and Neoplasia, 20(1-2), 5-7. [More Information]
  • Wong-Brown, M., Meldrum, C., Carpenter, J., Clarke, C., Narod, S., Jakubowska, A., Rudnicka, H., Lubinski, J., Scott, R. (2015). Prevalence of BRCA1 and BRCA2 germline mutations in patients with triple-negative breast cancer. Breast Cancer Research and Treatment, 150(1), 71-80. [More Information]
  • Mote, P., Gompell, A., Howe, C., Hilton, H., Sestak, I., Cuzick, J., Dowsett, M., Hugol, D., Forgez, P., Byth Wilson, K., Graham, J., Clarke, C. (2015). Progesterone receptor A predominance is a discriminator of benefit from endocrine therapy in the ATAC trial. Breast Cancer Research and Treatment, 151(2), 309-318. [More Information]
  • Hilton, H., Doan, T., Graham, J., Oakes, S., Silvestri, A., Santucci, N., Kantimm, S., Huschtscha, L., Ormandy, C., Funder, J., Kuczek, E., Clarke, C., et al (2014). Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease. Oncotarget, 5(18), 8651-8664.
  • Khushi, M., Liddle, C., Clarke, C., Graham, J. (2014). Binding Sites Analyser (BiSA): Software for Genomic Binding Sites Archiving and Overlap Analysis. PloS One, 9(2), 1-12. [More Information]
  • Carpenter, J., Clarke, C. (2014). Biobanking Sustainability-Experiences of the Australian Breast Cancer Tissue Bank (ABCTB). Biopreservation and Biobanking, 12(6), 395-401. [More Information]
  • Khushi, M., Clarke, C., Graham, J. (2014). Bioinformatic analysis of cis-regulatory interactions between progesterone and estrogen receptors in breast cancer. PeerJ, 2, 1-20. [More Information]
  • Doan, T., Eriksson, N., Graham, J., Funder, J., Simpson, E., Kuczek, E., Clyne, C., Leedman, P., Tilley, W., Fuller, P., Clarke, C., et al (2014). Breast cancer prognosis predicted by nuclear receptor-coregulator networks. Molecular Oncology, 8(5), 998-1013. [More Information]
  • Purrington, K., Slettedahl, S., Bolla, M., Michailidou, K., Czene, K., Nevanlinna, H., Bojesen, S., Andrulis, I., Cox, A., Per, H., Clarke, C., Balleine, R., et al (2014). Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade. Human Molecular Genetics, 23(22), 6034-6046. [More Information]
  • Purrington, K., Slager, S., Eccles, D., Yannoukakos, D., Fasching, P., Miron, P., Jane, C., Chang-Claude, J., Martin, N., Montgomery, G., Clarke, C., et al (2014). Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. Carcinogenesis, 35(5), 1012-1019. [More Information]
  • Emmanuel, C., Chiew, Y., George, J., Etemadmoghadam, D., Anglesio, M., Sharma, R., Russell, P., Kennedy, C., Fereday, S., Hung, J., Hogg, R., Wain, G., Brand, A., Balleine, R., Clarke, C., Harnett, P., deFazio, A., et al (2014). Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver. Clinical Cancer Research, 20(24), 6618-6630. [More Information]
  • Oh, T., Bailey, P., Dray, E., Smith, A., Goode, J., Eriksson, N., Funder, J., Fuller, P., Simpson, E., Tilley, W., Clarke, C., et al (2014). PRMT2 and RORĪ³ expression are associated with breast cancer survival outcomes. Molecular Endocrinology, 28(7), 1166-1185. [More Information]
  • Hilton, H., Santucci, N., Silvestri, A., Kantimm, S., Huschtscha, L., Graham, J., Clarke, C. (2014). Progesterone stimulates progenitor cells in normal human breast and breast cancer cells. Breast Cancer Research and Treatment, 143(3), 423-433.
  • Spurdle, A., Couch, F., Parsons, M., McGuffog, L., Barrowdale, D., Bolla, M., Wang, Q., Healey, S., Schmutzler, R., Balleine, R., Carpenter, J., Clarke, C. (2014). Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia. Breast Cancer Research, 16(9), 1-16. [More Information]
  • Hilton, H., Kantimm, S., Graham, J., Clarke, C. (2013). Changed lineage composition is an early event in breast carcinogenesis. Histology and histopathology, 28(9), 1197-1204. [More Information]
  • Knower, K., Chand, A., Eriksson, N., Takagi, K., Miki, Y., Sasano, H., Visvader, J., Lindeman, G., Funder, J., Fuller, P., Graham, J., Clarke, C., et al (2013). Distinct nuclear receptor expression in stroma adjacent to breast tumors. Breast Cancer Research and Treatment, 142(1), 211-223. [More Information]
  • Khushi, M., Edwards, G., de Marcos, D., Carpenter, J., Graham, J., Clarke, C. (2013). Open source tools for management and archiving of digital microscopy data to allow integration with patient pathology and treatment information. Diagnostic Pathology, 8(1), 1-7. [More Information]
  • Webster, L., Provan, P., Graham, J., Byth Wilson, K., Walker, R., Davis, S., Salisbury, E., Morey, A., Ward, R., Hawkins, N., Clarke, C., Balleine, R., et al (2013). Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33. Pathology, 45(7), 629-636. [More Information]
  • Muscat, G., Eriksson, N., Byth Wilson, K., Loi, S., Graham, D., Jindal, S., Davis, M., Clyne, C., Funder, J., Simpson, E., Kuczek, E., Clarke, C., et al (2013). Research Resource: Nuclear Receptors as Transcriptome: Discriminant and Prognostic Value in Breast Cancer. Molecular Endocrinology, 27(2), 350-365. [More Information]
  • Khushi, M., Carpenter, J., Balleine, R., Clarke, C. (2012). Development of a data entry auditing protocol and quality assurance for a tissue bank database. Cell and Tissue Banking, 13(1), 9-13. [More Information]
  • Khushi, M., Carpenter, J., Balleine, R., Clarke, C. (2012). Electronic Biorepository Application System: Web-Based Software to Manage Receipt, Peer Review, and Approval of Researcher Applications. Biopreservation and Biobanking, 10(1), 37-44. [More Information]
  • Clarke, C., Graham, J. (2012). Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes. PloS One, 7(4), 1-14. [More Information]
  • Graham, J., Clarke, C. (2012). Preview: MCE special issue on molecular mechanisms of action in progesterone signalling. Molecular And Cellular Endocrinology, 357(1/2), 1-3. [More Information]
  • Hilton, H., Graham, J., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, L., Mote, P., Clarke, C. (2012). Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast. Molecular And Cellular Endocrinology, 361(1-2), 191-201. [More Information]
  • Dowhan, D., Harrison, M., Eriksson, N., Bailey, P., Pearen, M., Fuller, P., Funder, J., Simpson, E., Leedman, P., Tilley, W., Clarke, C., et al (2012). Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes. Endocrine-Related Cancer, 19(4), 509-526. [More Information]
  • Haiman, C., Chen, G., Vachon, C., Canzian, F., Dunning, A., Millikan, R., Wang, X., Ademuyiwa, F., Ahmed, S., Ambrosone, C., Balleine, R., Carpenter, J., Clarke, C., et al (2011). A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nature Genetics, 43(12), 1210-1215. [More Information]
  • Stevens, K., Vachon, C., Lee, A., Slager, S., Lesnick, T., Oswald, C., Fasching, P., Miron, P., Carpenter, J., Clarke, C., Balleine, R., et al (2011). Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer. Cancer Research, 71(19), 6240-6249. [More Information]
  • Emmanuel, C., Gava, N., Kennedy, C., Balleine, R., Sharma, R., Wain, G., Brand, A., Hogg, R., Etemadmoghadam, D., George, J., Clarke, C., Harnett, P., deFazio, A., et al (2011). Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis. PloS One, 6(3), e17617-1-e17617-18. [More Information]
  • Pathmanathan, N., Salisbury, E., Provan, P., Bilous, M., Byth Wilson, K., Milliken, J., Clarke, C., Balleine, R. (2010). A class discovery and class prediction approach to histopathological classification of mammographic screen detected columnar cell lesions of the breast. Pathology, 42(1), 28-36. [More Information]
  • Joshi, P., Jackson, H., Beristain, A., Di Grappa, M., Mote, P., Clarke, C., Stingl, J., Khokha, R., Waterhouse, P. (2010). Progesterone induces adult mammary stem cell expansion. Nature, 465(7299), 803-807. [More Information]
  • Hilton, H., Kalyuga, M., Cowley, M., Alles, M., Lee, H., Caldon, C., Blazek, K., Kaplan, W., Musgrove, E., Daly, R., Graham, J., Clarke, C., et al (2010). The Antiproliferative Effects of Progestins in T47D Breast Cancer Cells Are Tempered by Progestin Induction of the ETS Transcription Factor Elf5. Molecular Endocrinology, 24(7), 1380-1392. [More Information]
  • Graham, J., Mote, P., Salagame, U., Van Dijk, J., Balleine, R., Huschtscha-Holliday, L., Reddel, R., Clarke, C. (2009). DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology, 150(7), 3318-3326. [More Information]
  • Graham, J., Mote, P., Salagame, U., Balleine, R., Huschtscha-Holliday, L., Clarke, C. (2009). Hormone-Responsive Model of Primary Human Breast Epithelium. Journal of Mammary Gland Biology and Neoplasia, 14(4), 367-379. [More Information]
  • Graham, J., Hanson, A., Croft, A., Fox, A., Clarke, C. (2009). Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci. The F A S E B Journal, 23(2), 546-556. [More Information]
  • Scarpin, K., Graham, J., Mote, P., Clarke, C. (2009). Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression. Nuclear Receptor Signaling, 7, 1-13. [More Information]
  • Cops, E., Bianco-Miotto, T., Moore, N., Clarke, C., Birrell, S., Butler, L., Tilley, W. (2008). Antiproliferative actions of the synthetic androgen, mibolerone, in breast cancer cells are mediated by both androgen and progesterone receptors. Journal of Steroid Biochemistry and Molecular Biology, 110(3-5), 236-243. [More Information]
  • Gava, N., Clarke, C., Bye, C., Byth Wilson, K., deFazio, A. (2008). Global gene expression profiles of ovarian surface epithelial cells in vivo. Journal of Molecular Endocrinology, 40, 281-296. [More Information]
  • Balleine, R., Webster, L., Davis, S., Salisbury, E., Palazzo, J., Schwartz, G., Cornfield, D., Walker, R., Byth Wilson, K., Clarke, C., et al (2008). Molecular Grading of Ductal Carcinoma In situ of the Breast. Clinical Cancer Research, 14(24), 8244-8252. [More Information]
  • Webster, L., Lee, S., Ringland, C., Morey, A., Hanby, A., Morgan, G., Byth Wilson, K., Mote, P., Provan, P., Ellis, I., Lamoury, G., Clarke, C., Balleine, R., et al (2008). Poor-prognosis estrogen receptor-positive breast cancer identified by histopathologic subclassification. Clinical Cancer Research, 14(20), 6625-6633. [More Information]
  • Easton, D., Pooley, K., Dunning, A., Pharoah, P., Thompson, D., Ballinger, D., Struewing, J., Morrison, J., Field, H., Luben, R., et al (2007). Genome-wide association study identifies novel breast cancer susceptibility loci. Nature, 447(7148), 1087-1093. [More Information]
  • Gurney, H., Wong, M., Balleine, R., Rivory, L., McLachlan, A., Hoskins, J., Wilcken, N., Clarke, C., Mann, G., Collins, M., et al (2007). Imatinib Disposition and ABCB1 (MDR1, P-Glycoprotein) Genotype. Clinical Pharmacology & Therapeutics, 82(1), 33-40. [More Information]
  • Mote, P., Graham, J., Clarke, C. (2007). Progesterone receptor isoforms in normal and malignant breast. Ernst Schering Research Foundation Workshop, (1), 77-107. [More Information]
  • Mann, G., Thorne, H., Balleine, R., Butow, P., Clarke, C., Edkins, E., Evans, G., Fereday, S., Haan, E., Gattas, M., Kirk, J., Leary, J., Pupo, G., et al (2006). Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource. Breast Cancer Research, 8(1), 1-15. [More Information]
  • Arnett-Mansfield, R., Graham, J., Hanson, A., Mote, P., Gompel, A., Scurr, L., Gava, N., deFazio, A., Clarke, C. (2006). Focal subnuclear distribution of progesterone receptor is ligand-dependent and associated with transcriptional activity. Molecular Endocrinology, 21(1), 14-29. [More Information]
  • Mote, P., Arnett-Mansfield, R., Gava, N., deFazio, A., Mulac-Jericevic, B., Conneely, O., Clarke, C. (2006). Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Endocrinology, 147(12), 5503-5512. [More Information]
  • WONG, M., Balleine, R., Blair, E., McLachlan, A., Ackland, S., Garg, M., Evans, S., Farlow, D., Collins, M., Rivory, L., Hoskins, J., Mann, G., Clarke, C., Gurney, H. (2006). Predictors of Vinorelbine Pharmacokinetics and Pharmacodynamics in Patients With Cancer. Journal of Clinical Oncology, 24(16), 2448-2455. [More Information]
  • Cowell, L., Graham, J., Bouton, A., Clarke, C., O'Neill, G. (2006). Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway. Oncogene, 25(58), 7597-7607. [More Information]
  • Graham, J., Yager, M., Hill, H., Byth Wilson, K., O'Neill, G., Clarke, C. (2005). Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells. Molecular Endocrinology, 19(11), 2713-2735. [More Information]
  • Aghmesheh, M., Edwards, L., Clarke, C., Byth Wilson, K., Katzenellenbogen, B., Russell, P., Friedlander, M., Tucker, K., deFazio, A. (2005). Expression of steroid hormone receptors in BRCA1-associated ovarian carcinomas. Gynecologic Oncology, 97(1), 16-25. [More Information]
  • Wong, M., Evans, S., Rivory, L., Hoskins, J., Mann, G., Farlow, D., Clarke, C., Balleine, R., Gurney, H. (2005). Hepatic technetium Tc 99m-labeled sestamibi elimination rate and ABCB1 (MDR1) genotype as indicators of ABCB1 (P-glycoprotein) activity in patients with cancer. Clinical Pharmacology & Therapeutics, 77(1), 33-42. [More Information]
  • Webster, L., Bilous, M., Willis, L., Byth Wilson, K., Burgemeister, F., Salisbury, E., Clarke, C., Balleine, R. (2005). Histopathologic indicators of breast cancer biology: insights from population mammographic screening. British Journal of Cancer, 92(8), 1366-1371. [More Information]
  • van den Heuvel, M., Chantakru, S., Xie, X., Evans, S., Tekpetey, F., Mote, P., Clarke, C., Croy, B. (2005). Trafficking of Circulating Pro-NK Cells to the Decidualizing Uterus: Regulatory Mechanisms in the Mouse and Human. Immunological Investigations, 34(3), 273-293. [More Information]
  • Wong, M., Balleine, R., Collins, M., Liddle, C., Clarke, C., Gurney, H. (2004). Cyp3A5 Genotype And Midazolam Clearance In Australian Patients Receiving Chemotherapy. Pharmacology and Therapeutics, 75(6), 529-538. [More Information]
  • McGowan, E., Saad, S., Bendall, L., Bradstock, K., Clarke, C. (2004). Effect Of Progesterone Receptor A Predominance On Breast Cancer Cell Migration Into Bone Marrow Fibroblasts. Breast Cancer Research and Treatment, 83(3), 211-220.
  • Balleine, R., Earls, P., Webster, L., Mote, P., deFazio, A., Harnett, P., Clarke, C. (2004). Expression Of Progesterone Receptor A And B Isoforms In Low-Grade Endometrial Stromal Sarcoma. International Journal of Gynecological Pathology, 23(2), 138-144.
  • Gava, N., Clarke, C., Byth Wilson, K., Arnett-Mansfield, R., deFazio, A. (2004). Expression Of Progesterone Receptors A And B In The Mouse Ovary During The Estrous Cycle. Endocrinology, 145(7), 3487-3494.
  • Mote, P., Leary, J., Avery, K., Sandelin, K., Chenevix-Trench, G., kConFab Investigators., Kirk, J., Clarke, C. (2004). Germ-Line Mutations In Brca1 Or Brca2 In The Normal Breast Are Associated With Altered Expression Of Estrogen-Responsive Proteins And The Predominance Of Progesterone Receptor A. Genes Chromosomes and Cancer, 39(3), 236-248. [More Information]
  • Arnett-Mansfield, R., deFazio, A., Mote, P., Clarke, C. (2004). Subnuclear Distribution Of Progesterone Receptors A And B In Normal And Malignant Endometrium. Journal of Clinical Endocrinology and Metabolism, 89(3), 1429-1442.
  • McGowan, E., Weinberger, R., Graham, J., Hill, H., Hughes, J., O'Neill, G., Clarke, C. (2003). Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels. Journal of Molecular Endocrinology, 31(2), 241-253.
  • Kennedy, C., Byth, K., Clarke, C., deFazio, A. (2002). Cell proliferation in the normal mouse mammary gland and inhibition by phenylbutyrate. Molecular Cancer Therapeutics, 1(12), 1025-1033.
  • Mote, P., Bartow, S., Tran, N., Clarke, C. (2002). Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcinogenesis. Breast Cancer Research and Treatment, 72(2), 163-172.
  • Graham, J., Clarke, C. (2002). Progesterone receptors - animal models and cell signaling in breast cancer: expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells. Breast Cancer Research, 4(5), 187-190.
  • Mote, P., Clarke, C., Johnston, J., Manninen, T., Tuohimaa, P. (2001). Detection of progesterone receptor forms A and B by immunohistochemical analysis. Journal of Clinical Pathology, 54, 624-630.
  • Tilley, W., Clarke, C., Birrell, S., Bruchovsky, N. (2001). Hormones and Cancer: new insights, new challenges. Trends in Endocrinology and Metabolism, 12(5), 186-188.
  • Arnett-Mansfield, R., Wain, G., Jaworski, R., Mote, P., Clarke, C., deFazio, A., Byth, K. (2001). Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium1. Cancer Research, 61, 4576-4582.
  • Balleine, R., Humphrey, K., Clarke, C. (2001). Tumour banks: providing human tissue for cancer research. Medical Journal of Australia, 175, 293-294.
  • Mote, P., Balleine, R., McGowan, E., Clarke, C. (2000). Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma. Human Reproduction, 15(supp3), 48-56.
  • Davis, T., Kennedy, C., Chiew, Y., Clarke, C., deFazio, A. (2000). Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells. Clinical Cancer Research, 6(11), 4334-4342.
  • Balleine, R., Schoenberg Fejzo, M., Sathasivam, P., Basset, P., Clarke, C., Byrne, J. (2000). The hD52 (TDP52) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma. Genes Chromosomes and Cancer, 29(1), 48-57.

Conferences

  • Carpenter, J., Clarke, C. (2006). Twenty-first century tissue banking: Lessons from the past are shaping the future - Breast Cancer Tissue Bank, Australia. ISBER 2006 7th Annual Meeting "The Repository of the Future", United States: Mary Ann Liebert Inc. Publishers.

2016

  • Purrington, K., Visscher, D., Wang, C., Yannoukakos, D., Hamann, U., Nevanlinna, H., Cox, A., Giles, G., Eckel-Passow, J., Clarke, C., Carpenter, J., et al (2016). Genes associated with histopathologic features of triple negative breast tumors predict molecular subtypes. Breast Cancer Research and Treatment, 157(1), 117-131. [More Information]
  • Zeng, C., Guo, X., Long, J., Kuchenbaecker, K., Droit, A., Michailidou, K., Ghoussaini, M., Kar, S., Freeman, A., Carpenter, J., Clarke, C., et al (2016). Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. Breast Cancer Research, 18(1), 1-21. [More Information]
  • Southey, M., Goldgar, D., Winqvist, R., Pylkas, K., Couch, F., Tischkowitz, M., Foulkes, W., Dennis, J., Michailidou, K., et al, Carpenter, J., Clarke, C. (2016). PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS. Journal of Medical Genetics, tba(tba), tba-tba. [More Information]
  • Oh, T., Wang, S., Acharya, B., Goode, J., Graham, J., Clarke, C., Yap, A., Muscat, G. (2016). The Nuclear Receptor, ROR(gamma), Regulates Pathways Necessary for Breast Cancer Metastasis. EBioMedicine, 6, 59-72. [More Information]

2015

  • Bonneterre, J., Hutt, E., Bosq, J., Graham, J., Powell, M., Leblanc, E., Fujiwara, K., Herzog, T., Coleman, R., Clarke, C., et al (2015). Development of a technique to detect the activated form of the progesterone receptor and correlation with clinical and histopathological characteristics of endometrioid adenocarcinoma of the uterine corpus. Gynecologic Oncology, 138(3), 663-667. [More Information]
  • Hilton, H., Clarke, C. (2015). Impact of Progesterone on Stem/Progenitor Cells in the Human Breast. Journal of Mammary Gland Biology and Neoplasia, 20(1-2), 27-37. [More Information]
  • Hilton, H., Graham, J., Clarke, C. (2015). Minireview: Progesterone Regulation of Proliferation in the Normal Human Breast and in Breast Cancer: A Tale of Two Scenarios? Molecular Endocrinology, 29(9), 1230-1242. [More Information]
  • Mavaddat, N., Pharoah, P., Michailidou, K., Tyrer, J., Book, M., Bolla, M., Wang, Q., Dennis, J., Dunning, A., Shah, M., Balleine, R., Carpenter, J., Clarke, C., et al (2015). Prediction of breast cancer risk based on profiling with common genetic variants. Journal of the National Cancer Institute, 107(5), 1-15. [More Information]
  • Clarke, C., Dontu, G., Hilton, H., Meier-Abt, F., Sartorius, C. (2015). Preface. Journal of Mammary Gland Biology and Neoplasia, 20(1-2), 5-7. [More Information]
  • Wong-Brown, M., Meldrum, C., Carpenter, J., Clarke, C., Narod, S., Jakubowska, A., Rudnicka, H., Lubinski, J., Scott, R. (2015). Prevalence of BRCA1 and BRCA2 germline mutations in patients with triple-negative breast cancer. Breast Cancer Research and Treatment, 150(1), 71-80. [More Information]
  • Mote, P., Gompell, A., Howe, C., Hilton, H., Sestak, I., Cuzick, J., Dowsett, M., Hugol, D., Forgez, P., Byth Wilson, K., Graham, J., Clarke, C. (2015). Progesterone receptor A predominance is a discriminator of benefit from endocrine therapy in the ATAC trial. Breast Cancer Research and Treatment, 151(2), 309-318. [More Information]

2014

  • Hilton, H., Doan, T., Graham, J., Oakes, S., Silvestri, A., Santucci, N., Kantimm, S., Huschtscha, L., Ormandy, C., Funder, J., Kuczek, E., Clarke, C., et al (2014). Acquired convergence of hormone signaling in breast cancer: ER and PR transition from functionally distinct in normal breast to predictors of metastatic disease. Oncotarget, 5(18), 8651-8664.
  • Khushi, M., Liddle, C., Clarke, C., Graham, J. (2014). Binding Sites Analyser (BiSA): Software for Genomic Binding Sites Archiving and Overlap Analysis. PloS One, 9(2), 1-12. [More Information]
  • Carpenter, J., Clarke, C. (2014). Biobanking Sustainability-Experiences of the Australian Breast Cancer Tissue Bank (ABCTB). Biopreservation and Biobanking, 12(6), 395-401. [More Information]
  • Khushi, M., Clarke, C., Graham, J. (2014). Bioinformatic analysis of cis-regulatory interactions between progesterone and estrogen receptors in breast cancer. PeerJ, 2, 1-20. [More Information]
  • Doan, T., Eriksson, N., Graham, J., Funder, J., Simpson, E., Kuczek, E., Clyne, C., Leedman, P., Tilley, W., Fuller, P., Clarke, C., et al (2014). Breast cancer prognosis predicted by nuclear receptor-coregulator networks. Molecular Oncology, 8(5), 998-1013. [More Information]
  • Purrington, K., Slettedahl, S., Bolla, M., Michailidou, K., Czene, K., Nevanlinna, H., Bojesen, S., Andrulis, I., Cox, A., Per, H., Clarke, C., Balleine, R., et al (2014). Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade. Human Molecular Genetics, 23(22), 6034-6046. [More Information]
  • Purrington, K., Slager, S., Eccles, D., Yannoukakos, D., Fasching, P., Miron, P., Jane, C., Chang-Claude, J., Martin, N., Montgomery, G., Clarke, C., et al (2014). Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer. Carcinogenesis, 35(5), 1012-1019. [More Information]
  • Emmanuel, C., Chiew, Y., George, J., Etemadmoghadam, D., Anglesio, M., Sharma, R., Russell, P., Kennedy, C., Fereday, S., Hung, J., Hogg, R., Wain, G., Brand, A., Balleine, R., Clarke, C., Harnett, P., deFazio, A., et al (2014). Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver. Clinical Cancer Research, 20(24), 6618-6630. [More Information]
  • Oh, T., Bailey, P., Dray, E., Smith, A., Goode, J., Eriksson, N., Funder, J., Fuller, P., Simpson, E., Tilley, W., Clarke, C., et al (2014). PRMT2 and RORĪ³ expression are associated with breast cancer survival outcomes. Molecular Endocrinology, 28(7), 1166-1185. [More Information]
  • Hilton, H., Santucci, N., Silvestri, A., Kantimm, S., Huschtscha, L., Graham, J., Clarke, C. (2014). Progesterone stimulates progenitor cells in normal human breast and breast cancer cells. Breast Cancer Research and Treatment, 143(3), 423-433.
  • Spurdle, A., Couch, F., Parsons, M., McGuffog, L., Barrowdale, D., Bolla, M., Wang, Q., Healey, S., Schmutzler, R., Balleine, R., Carpenter, J., Clarke, C. (2014). Refined histopathological predictors of BRCA1 and BRCA2 mutation status: a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia. Breast Cancer Research, 16(9), 1-16. [More Information]

2013

  • Hilton, H., Kantimm, S., Graham, J., Clarke, C. (2013). Changed lineage composition is an early event in breast carcinogenesis. Histology and histopathology, 28(9), 1197-1204. [More Information]
  • Knower, K., Chand, A., Eriksson, N., Takagi, K., Miki, Y., Sasano, H., Visvader, J., Lindeman, G., Funder, J., Fuller, P., Graham, J., Clarke, C., et al (2013). Distinct nuclear receptor expression in stroma adjacent to breast tumors. Breast Cancer Research and Treatment, 142(1), 211-223. [More Information]
  • Khushi, M., Edwards, G., de Marcos, D., Carpenter, J., Graham, J., Clarke, C. (2013). Open source tools for management and archiving of digital microscopy data to allow integration with patient pathology and treatment information. Diagnostic Pathology, 8(1), 1-7. [More Information]
  • Webster, L., Provan, P., Graham, J., Byth Wilson, K., Walker, R., Davis, S., Salisbury, E., Morey, A., Ward, R., Hawkins, N., Clarke, C., Balleine, R., et al (2013). Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33. Pathology, 45(7), 629-636. [More Information]
  • Muscat, G., Eriksson, N., Byth Wilson, K., Loi, S., Graham, D., Jindal, S., Davis, M., Clyne, C., Funder, J., Simpson, E., Kuczek, E., Clarke, C., et al (2013). Research Resource: Nuclear Receptors as Transcriptome: Discriminant and Prognostic Value in Breast Cancer. Molecular Endocrinology, 27(2), 350-365. [More Information]

2012

  • Khushi, M., Carpenter, J., Balleine, R., Clarke, C. (2012). Development of a data entry auditing protocol and quality assurance for a tissue bank database. Cell and Tissue Banking, 13(1), 9-13. [More Information]
  • Khushi, M., Carpenter, J., Balleine, R., Clarke, C. (2012). Electronic Biorepository Application System: Web-Based Software to Manage Receipt, Peer Review, and Approval of Researcher Applications. Biopreservation and Biobanking, 10(1), 37-44. [More Information]
  • Hilton, H., Graham, J., Clarke, C. (2012). Estrogen and Progestin Stimulation of Breast Proliferation. In R. Paul Robinson (Eds.), Translational Endocrinology & Metabolism: Breast Cancer Update, (pp. 1-28). Maryland, United States: The Endocrine Society.
  • Clarke, C., Graham, J. (2012). Non-overlapping progesterone receptor cistromes contribute to cell-specific transcriptional outcomes. PloS One, 7(4), 1-14. [More Information]
  • Graham, J., Clarke, C. (2012). Preview: MCE special issue on molecular mechanisms of action in progesterone signalling. Molecular And Cellular Endocrinology, 357(1/2), 1-3. [More Information]
  • Hilton, H., Graham, J., Kantimm, S., Santucci, N., Cloosterman, D., Huschtscha, L., Mote, P., Clarke, C. (2012). Progesterone and estrogen receptors segregate into different cell subpopulations in the normal human breast. Molecular And Cellular Endocrinology, 361(1-2), 191-201. [More Information]
  • Dowhan, D., Harrison, M., Eriksson, N., Bailey, P., Pearen, M., Fuller, P., Funder, J., Simpson, E., Leedman, P., Tilley, W., Clarke, C., et al (2012). Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes. Endocrine-Related Cancer, 19(4), 509-526. [More Information]

2011

  • Haiman, C., Chen, G., Vachon, C., Canzian, F., Dunning, A., Millikan, R., Wang, X., Ademuyiwa, F., Ahmed, S., Ambrosone, C., Balleine, R., Carpenter, J., Clarke, C., et al (2011). A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nature Genetics, 43(12), 1210-1215. [More Information]
  • Stevens, K., Vachon, C., Lee, A., Slager, S., Lesnick, T., Oswald, C., Fasching, P., Miron, P., Carpenter, J., Clarke, C., Balleine, R., et al (2011). Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer. Cancer Research, 71(19), 6240-6249. [More Information]
  • Emmanuel, C., Gava, N., Kennedy, C., Balleine, R., Sharma, R., Wain, G., Brand, A., Hogg, R., Etemadmoghadam, D., George, J., Clarke, C., Harnett, P., deFazio, A., et al (2011). Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis. PloS One, 6(3), e17617-1-e17617-18. [More Information]

2010

  • Pathmanathan, N., Salisbury, E., Provan, P., Bilous, M., Byth Wilson, K., Milliken, J., Clarke, C., Balleine, R. (2010). A class discovery and class prediction approach to histopathological classification of mammographic screen detected columnar cell lesions of the breast. Pathology, 42(1), 28-36. [More Information]
  • Joshi, P., Jackson, H., Beristain, A., Di Grappa, M., Mote, P., Clarke, C., Stingl, J., Khokha, R., Waterhouse, P. (2010). Progesterone induces adult mammary stem cell expansion. Nature, 465(7299), 803-807. [More Information]
  • Hilton, H., Kalyuga, M., Cowley, M., Alles, M., Lee, H., Caldon, C., Blazek, K., Kaplan, W., Musgrove, E., Daly, R., Graham, J., Clarke, C., et al (2010). The Antiproliferative Effects of Progestins in T47D Breast Cancer Cells Are Tempered by Progestin Induction of the ETS Transcription Factor Elf5. Molecular Endocrinology, 24(7), 1380-1392. [More Information]

2009

  • Graham, J., Mote, P., Salagame, U., Van Dijk, J., Balleine, R., Huschtscha-Holliday, L., Reddel, R., Clarke, C. (2009). DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology, 150(7), 3318-3326. [More Information]
  • Graham, J., Mote, P., Salagame, U., Balleine, R., Huschtscha-Holliday, L., Clarke, C. (2009). Hormone-Responsive Model of Primary Human Breast Epithelium. Journal of Mammary Gland Biology and Neoplasia, 14(4), 367-379. [More Information]
  • Graham, J., Hanson, A., Croft, A., Fox, A., Clarke, C. (2009). Nuclear matrix binding is critical for progesterone receptor movement into nuclear foci. The F A S E B Journal, 23(2), 546-556. [More Information]
  • Scarpin, K., Graham, J., Mote, P., Clarke, C. (2009). Progesterone action in human tissues: regulation by progesterone receptor (PR) isoform expression, nuclear positioning and coregulator expression. Nuclear Receptor Signaling, 7, 1-13. [More Information]

2008

  • Cops, E., Bianco-Miotto, T., Moore, N., Clarke, C., Birrell, S., Butler, L., Tilley, W. (2008). Antiproliferative actions of the synthetic androgen, mibolerone, in breast cancer cells are mediated by both androgen and progesterone receptors. Journal of Steroid Biochemistry and Molecular Biology, 110(3-5), 236-243. [More Information]
  • Gava, N., Clarke, C., Bye, C., Byth Wilson, K., deFazio, A. (2008). Global gene expression profiles of ovarian surface epithelial cells in vivo. Journal of Molecular Endocrinology, 40, 281-296. [More Information]
  • Balleine, R., Webster, L., Davis, S., Salisbury, E., Palazzo, J., Schwartz, G., Cornfield, D., Walker, R., Byth Wilson, K., Clarke, C., et al (2008). Molecular Grading of Ductal Carcinoma In situ of the Breast. Clinical Cancer Research, 14(24), 8244-8252. [More Information]
  • Webster, L., Lee, S., Ringland, C., Morey, A., Hanby, A., Morgan, G., Byth Wilson, K., Mote, P., Provan, P., Ellis, I., Lamoury, G., Clarke, C., Balleine, R., et al (2008). Poor-prognosis estrogen receptor-positive breast cancer identified by histopathologic subclassification. Clinical Cancer Research, 14(20), 6625-6633. [More Information]

2007

  • Easton, D., Pooley, K., Dunning, A., Pharoah, P., Thompson, D., Ballinger, D., Struewing, J., Morrison, J., Field, H., Luben, R., et al (2007). Genome-wide association study identifies novel breast cancer susceptibility loci. Nature, 447(7148), 1087-1093. [More Information]
  • Gurney, H., Wong, M., Balleine, R., Rivory, L., McLachlan, A., Hoskins, J., Wilcken, N., Clarke, C., Mann, G., Collins, M., et al (2007). Imatinib Disposition and ABCB1 (MDR1, P-Glycoprotein) Genotype. Clinical Pharmacology & Therapeutics, 82(1), 33-40. [More Information]
  • Mote, P., Graham, J., Clarke, C. (2007). Progesterone receptor isoforms in normal and malignant breast. Ernst Schering Research Foundation Workshop, (1), 77-107. [More Information]

2006

  • Mann, G., Thorne, H., Balleine, R., Butow, P., Clarke, C., Edkins, E., Evans, G., Fereday, S., Haan, E., Gattas, M., Kirk, J., Leary, J., Pupo, G., et al (2006). Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource. Breast Cancer Research, 8(1), 1-15. [More Information]
  • Arnett-Mansfield, R., Graham, J., Hanson, A., Mote, P., Gompel, A., Scurr, L., Gava, N., deFazio, A., Clarke, C. (2006). Focal subnuclear distribution of progesterone receptor is ligand-dependent and associated with transcriptional activity. Molecular Endocrinology, 21(1), 14-29. [More Information]
  • Mote, P., Arnett-Mansfield, R., Gava, N., deFazio, A., Mulac-Jericevic, B., Conneely, O., Clarke, C. (2006). Overlapping and distinct expression of progesterone receptors A and B in mouse uterus and mammary gland during the estrous cycle. Endocrinology, 147(12), 5503-5512. [More Information]
  • WONG, M., Balleine, R., Blair, E., McLachlan, A., Ackland, S., Garg, M., Evans, S., Farlow, D., Collins, M., Rivory, L., Hoskins, J., Mann, G., Clarke, C., Gurney, H. (2006). Predictors of Vinorelbine Pharmacokinetics and Pharmacodynamics in Patients With Cancer. Journal of Clinical Oncology, 24(16), 2448-2455. [More Information]
  • Cowell, L., Graham, J., Bouton, A., Clarke, C., O'Neill, G. (2006). Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway. Oncogene, 25(58), 7597-7607. [More Information]
  • Carpenter, J., Clarke, C. (2006). Twenty-first century tissue banking: Lessons from the past are shaping the future - Breast Cancer Tissue Bank, Australia. ISBER 2006 7th Annual Meeting "The Repository of the Future", United States: Mary Ann Liebert Inc. Publishers.

2005

  • Graham, J., Yager, M., Hill, H., Byth Wilson, K., O'Neill, G., Clarke, C. (2005). Altered progesterone receptor isoform expression remodels progestin responsiveness of breast cancer cells. Molecular Endocrinology, 19(11), 2713-2735. [More Information]
  • Aghmesheh, M., Edwards, L., Clarke, C., Byth Wilson, K., Katzenellenbogen, B., Russell, P., Friedlander, M., Tucker, K., deFazio, A. (2005). Expression of steroid hormone receptors in BRCA1-associated ovarian carcinomas. Gynecologic Oncology, 97(1), 16-25. [More Information]
  • Wong, M., Evans, S., Rivory, L., Hoskins, J., Mann, G., Farlow, D., Clarke, C., Balleine, R., Gurney, H. (2005). Hepatic technetium Tc 99m-labeled sestamibi elimination rate and ABCB1 (MDR1) genotype as indicators of ABCB1 (P-glycoprotein) activity in patients with cancer. Clinical Pharmacology & Therapeutics, 77(1), 33-42. [More Information]
  • Webster, L., Bilous, M., Willis, L., Byth Wilson, K., Burgemeister, F., Salisbury, E., Clarke, C., Balleine, R. (2005). Histopathologic indicators of breast cancer biology: insights from population mammographic screening. British Journal of Cancer, 92(8), 1366-1371. [More Information]
  • van den Heuvel, M., Chantakru, S., Xie, X., Evans, S., Tekpetey, F., Mote, P., Clarke, C., Croy, B. (2005). Trafficking of Circulating Pro-NK Cells to the Decidualizing Uterus: Regulatory Mechanisms in the Mouse and Human. Immunological Investigations, 34(3), 273-293. [More Information]

2004

  • Wong, M., Balleine, R., Collins, M., Liddle, C., Clarke, C., Gurney, H. (2004). Cyp3A5 Genotype And Midazolam Clearance In Australian Patients Receiving Chemotherapy. Pharmacology and Therapeutics, 75(6), 529-538. [More Information]
  • McGowan, E., Saad, S., Bendall, L., Bradstock, K., Clarke, C. (2004). Effect Of Progesterone Receptor A Predominance On Breast Cancer Cell Migration Into Bone Marrow Fibroblasts. Breast Cancer Research and Treatment, 83(3), 211-220.
  • Balleine, R., Earls, P., Webster, L., Mote, P., deFazio, A., Harnett, P., Clarke, C. (2004). Expression Of Progesterone Receptor A And B Isoforms In Low-Grade Endometrial Stromal Sarcoma. International Journal of Gynecological Pathology, 23(2), 138-144.
  • Gava, N., Clarke, C., Byth Wilson, K., Arnett-Mansfield, R., deFazio, A. (2004). Expression Of Progesterone Receptors A And B In The Mouse Ovary During The Estrous Cycle. Endocrinology, 145(7), 3487-3494.
  • Mote, P., Leary, J., Avery, K., Sandelin, K., Chenevix-Trench, G., kConFab Investigators., Kirk, J., Clarke, C. (2004). Germ-Line Mutations In Brca1 Or Brca2 In The Normal Breast Are Associated With Altered Expression Of Estrogen-Responsive Proteins And The Predominance Of Progesterone Receptor A. Genes Chromosomes and Cancer, 39(3), 236-248. [More Information]
  • Arnett-Mansfield, R., deFazio, A., Mote, P., Clarke, C. (2004). Subnuclear Distribution Of Progesterone Receptors A And B In Normal And Malignant Endometrium. Journal of Clinical Endocrinology and Metabolism, 89(3), 1429-1442.

2003

  • McGowan, E., Weinberger, R., Graham, J., Hill, H., Hughes, J., O'Neill, G., Clarke, C. (2003). Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels. Journal of Molecular Endocrinology, 31(2), 241-253.

2002

  • Kennedy, C., Byth, K., Clarke, C., deFazio, A. (2002). Cell proliferation in the normal mouse mammary gland and inhibition by phenylbutyrate. Molecular Cancer Therapeutics, 1(12), 1025-1033.
  • Mote, P., Bartow, S., Tran, N., Clarke, C. (2002). Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcinogenesis. Breast Cancer Research and Treatment, 72(2), 163-172.
  • Graham, J., Clarke, C. (2002). Progesterone receptors - animal models and cell signaling in breast cancer: expression and transcriptional activity of progesterone receptor A and progesterone receptor B in mammalian cells. Breast Cancer Research, 4(5), 187-190.

2001

  • Mote, P., Clarke, C., Johnston, J., Manninen, T., Tuohimaa, P. (2001). Detection of progesterone receptor forms A and B by immunohistochemical analysis. Journal of Clinical Pathology, 54, 624-630.
  • Tilley, W., Clarke, C., Birrell, S., Bruchovsky, N. (2001). Hormones and Cancer: new insights, new challenges. Trends in Endocrinology and Metabolism, 12(5), 186-188.
  • Arnett-Mansfield, R., Wain, G., Jaworski, R., Mote, P., Clarke, C., deFazio, A., Byth, K. (2001). Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium1. Cancer Research, 61, 4576-4582.
  • Balleine, R., Humphrey, K., Clarke, C. (2001). Tumour banks: providing human tissue for cancer research. Medical Journal of Australia, 175, 293-294.

2000

  • Mote, P., Balleine, R., McGowan, E., Clarke, C. (2000). Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma. Human Reproduction, 15(supp3), 48-56.
  • Davis, T., Kennedy, C., Chiew, Y., Clarke, C., deFazio, A. (2000). Histone deacetylase inhibitors decrease proliferation and modulate cell cycle gene expression in normal mammary epithelial cells. Clinical Cancer Research, 6(11), 4334-4342.
  • Balleine, R., Schoenberg Fejzo, M., Sathasivam, P., Basset, P., Clarke, C., Byrne, J. (2000). The hD52 (TDP52) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma. Genes Chromosomes and Cancer, 29(1), 48-57.

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