Dr Claire Goldsbury
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Dr Claire Goldsbury

Senior Lecturer, Discipline of Anatomy and Histology, School of Medical Sciences
Phone
+61 2 9351 0878
Dr Claire Goldsbury

Research interests include the role of glia in the development of Alzheimer's disease

Neurosciences and Mental Health
Project titleResearch student
Investigating Extracellular Vesicles signalling in the pathophysiology of Multiple SclerosisDrishya MAINALI

Publications

Book Chapters

  • Goldsbury, C., Scheuring, S. (2003). Atomic Force Microscopy in biology. In John E. Coligan (Eds.), Current Protocols in Protein Science, (pp. 17.7.1-17.7.19). John Wiley & Sons.

Journals

  • Rogerson-Wood, L., Goldsbury, C., Sawatari, A., Leamey, C. (2024). An early enriched experience drives targeted microglial engulfment of miswired neural circuitry during a restricted postnatal period. GLIA, 72(7), 1217-1235. [More Information]
  • Rogerson-Wood, L., Petersen, J., Kairouz, A., Goldsbury, C., Sawatari, A., Leamey, C. (2023). An Early Enriched Experience Drives an Activated Microglial Profile at Site of Corrective Neuroplasticity in Ten-m3 Knock-Out Mice. eNeuro, 10(1). [More Information]
  • Filipello, F., Goldsbury, C., You, S., Locca, A., Karch, C., Piccio, L. (2022). Soluble TREM2: Innocent bystander or active player in neurological diseases? Neurobiology of Disease, 165, 105630. [More Information]

Conferences

  • Goldsbury, C., Aebi, U., Frey, P. (2007). Assembly and structure of Alzheimer's A-beta amyloid-like fibrils. American Society for Cell Biology Meeting.
  • Goldsbury, C. (2007). Quantification of the amyloid precursor protein and tau for the study of axonal trafficking pathways. International Brain Research Organisation World Congress of Neuroscience.
  • Goldsbury, C. (2006). Is amyloid-beta generation linked to axonal transport of APP? The sixth Eibsee Meeting, Not Published: Not Published.

2024

  • Rogerson-Wood, L., Goldsbury, C., Sawatari, A., Leamey, C. (2024). An early enriched experience drives targeted microglial engulfment of miswired neural circuitry during a restricted postnatal period. GLIA, 72(7), 1217-1235. [More Information]

2023

  • Rogerson-Wood, L., Petersen, J., Kairouz, A., Goldsbury, C., Sawatari, A., Leamey, C. (2023). An Early Enriched Experience Drives an Activated Microglial Profile at Site of Corrective Neuroplasticity in Ten-m3 Knock-Out Mice. eNeuro, 10(1). [More Information]

2022

  • Filipello, F., Goldsbury, C., You, S., Locca, A., Karch, C., Piccio, L. (2022). Soluble TREM2: Innocent bystander or active player in neurological diseases? Neurobiology of Disease, 165, 105630. [More Information]

2021

  • Abey, A., Davies, D., Goldsbury, C., Buckland, M., Valenzuela, M., Duncan, T. (2021). Distribution of tau hyperphosphorylation in canine dementia resembles early Alzheimer’s disease and other tauopathies. Brain Pathology, 31(1), 144-162. [More Information]

2020

  • Paasila, P., Davies, D., Sutherland, G., Goldsbury, C. (2020). Clustering of activated microglia occurs before the formation of dystrophic neurites in the evolution of A Beta plaques in Alzheimer's disease. Free Neuropathology, 1, 1-18. [More Information]

2019

  • Hansra, G., Popov, G., Banaczek, P., Vogiatzis, M., Jegathees, T., Goldbury, C., Cullen, K. (2019). The neuritic plaque in Alzheimer's disease: perivascular degeneration of neuronal processes. Neurobiology of Aging, 82, 88-101. [More Information]
  • Paasila, P., Davies, D., Kril, J., Goldsbury, C., Sutherland, G. (2019). The relationship between the morphological subtypes of microglia and Alzheimer's disease neuropathology. Brain Pathology, 29(6), 726-740. [More Information]

2018

  • Acosta, J., Watchon, M., Yuan, K., Fifita, J., Svahn, A., Don, E., Winnick, C., Blair, I., Nicholson, G., Cole, N., Goldsbury, C., et al (2018). Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease. Biology Open, 7(10), 1-7. [More Information]

2017

  • Watchon, M., Yuan, K., Mackovski, N., Svahn, A., Cole, N., Goldsbury, C., Rinkwitz, S., Becker, T., Nicholson, G., Laird, A. (2017). Calpain inhibition is protective in machado-joseph disease zebrafish due to induction of autophagy. Journal of Neuroscience, 37(32), 7782-7794. [More Information]
  • Davies, D., Ma, J., Jegathees, T., Goldsbury, C. (2017). Microglia show altered morphology and reduced arborization in human brain during aging and Alzheimer's disease. Brain Pathology, 27(6), 795-808. [More Information]

2016

  • Benda, A., Aitken, H., Davies, D., Whan, R., Goldsbury, C. (2016). STED imaging of tau filaments in Alzheimer's disease cortical grey matter. Journal of Structural Biology, 195(3), 345-352. [More Information]

2014

  • Rahman, T., Davies, D., Tannenberg, R., Fok, S., Shepherd, C., Dodd, P., Cullen, K., Goldsbury, C. (2014). Cofilin rods and aggregates concur with tau pathology and the development of alzheimer's disease. Journal of Alzheimer's Disease, 42(4), 1443-1460. [More Information]
  • Acosta, J., Goldsbury, C., Winnick, C., Badrock, A., Fraser, S., Laird, A., Hall, T., Don, E., Fifita, J., Blair, I., Nicholson, G., Cole, N. (2014). Mutant Human FUS Is Ubiquitously Mislocalized and Generates Persistent Stress Granules in Primary Cultured Transgenic Zebrafish Cells. PloS One, 9(6), 1-9. [More Information]

2013

  • Saberi, S., Du, Y., Christie, M., Goldsbury, C. (2013). Human Chorionic Gonadotropin Increases b-Cleavage of Amyloid Precursor Protein in SH-SY5Y Cells. Cellular and Molecular Neurobiology, 33(6), 747-751. [More Information]

2011

  • Goldsbury, C., Baxa, U., Simon, M., Steven, A., Engel, A., Wall, J., Aebi, U., Mueller, S. (2011). Amyloid Structure and Assembly: Insights from Scanning Transmission Electron Microscopy. Journal of Structural Biology, 173(1), 1-13. [More Information]
  • Whiteman, I., Minamide, L., Goh, D., Bamburg, J., Goldsbury, C. (2011). Rapid Changes in Phospho-MAP/Tau Epitopes during Neuronal Stress: Cofilin-Actin Rods Primarily Recruit Microtubule Binding Domain Epitopes. PloS One, 6(6), e20878-1-e20878-12. [More Information]

2010

  • Bamburg, J., Bernstein, B., Davis, R., Flynn, K., Goldsbury, C., Jensen, J., Maloney, M., Marsden, I., Minamide, L., et al (2010). ADF/Cofilin-actin rods in neurodegenerative diseases. Current Alzheimer Research, 7(3), 177-188. [More Information]

2009

  • Whiteman, I., Gervasio, O., Cullen, K., Guillemin, G., Jeong, E., Witting, P., Antao, S., Minamide, L., Bamburg, J., Goldsbury, C. (2009). Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. Journal of Neuroscience, 29(41), 12994-13005. [More Information]
  • Goldsbury, C., Scheuring, S., Kreplak, L. (2009). Introduction to atomic force microscopy (AFM) in biology. Current Protocols in Protein Science, , 17.7.1-17.7.19.

2008

  • Goldsbury, C., Whiteman, I., Jeong, E., Lim, Y. (2008). Oxidative stress increases levels of endogenous amyloid-β peptides secreted from primary chick brain neurons. Aging Cell, 7(5), 771-775. [More Information]

2007

  • Goldsbury, C., Aebi, U., Frey, P. (2007). Assembly and structure of Alzheimer's A-beta amyloid-like fibrils. American Society for Cell Biology Meeting.
  • Goldsbury, C., Thies, E., Konzack, S., Mandelkow, E. (2007). Quantification of Amyloid Precursor Protein and tau for the study of axonal traffic pathways. Journal of Neuroscience, 27(13), 3357-3363. [More Information]
  • Goldsbury, C. (2007). Quantification of the amyloid precursor protein and tau for the study of axonal trafficking pathways. International Brain Research Organisation World Congress of Neuroscience.

2006

  • Goldsbury, C., Mocanu, M., Thies, E., Kaether, C., Haass, C., Keller, P., Biernat, J., Mandelkow, E., Mandelkow, E. (2006). Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides. Traffic, 7(7), 873-888. [More Information]
  • Goldsbury, C. (2006). Is amyloid-beta generation linked to axonal transport of APP? The sixth Eibsee Meeting, Not Published: Not Published.
  • Goldsbury, C. (2006). Linkage of axonal transport and generation of amyloid-beta peptides. The 10th International Conference on Alzheimer's Disease and Related Disorders, Not Published: Not Published.

2005

  • Goldsbury, C., Frey, P., Olivieri, V., Aebi, U., Mueller, S. (2005). Multiple assembly pathways underlie amyloid-β fibril polymorphisms. Journal of Molecular Biology, 352(2), 282-298. [More Information]
  • Goldsbury, C., Green, J. (2005). Time-lapse atomic force microscopy in the characterization of amyloid-like fibril assembly and oligomeric intermediates. Methods in Molecular Biology, 299, 103-128. [More Information]

2004

  • Green, J., Kreplak, L., Goldsbury, C., Blatter, X., Stolz, M., Cooper, G., Seelig, A., Kistler, J., Aebi, U. (2004). Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide. Journal of Molecular Biology, 342(3), 877-887. [More Information]
  • Green, J., Goldsbury, C., Kistler, J., Cooper, G., Aebi, U. (2004). Human amylin oligomer growth and fibril elongation define two distinct phases in amyloid formation. Journal of Biological Chemistry, 279(13), 12206-12212. [More Information]

2003

  • Goldsbury, C., Scheuring, S. (2003). Atomic Force Microscopy in biology. In John E. Coligan (Eds.), Current Protocols in Protein Science, (pp. 17.7.1-17.7.19). John Wiley & Sons.
  • Green, J., Goldsbury, C., Mini, T., Sunderji, S., Frey, P., Kistler, J., Cooper, G., Aebi, U. (2003). Full-length Rat Amylin Forms Fibrils Following Substitution of Single Residues from Human Amylin. Journal of Molecular Biology, 326(4), 1147-1156. [More Information]

2002

  • Goldsbury, C. (2002). Tracking assembly and structure of amyloid-beta fibrils by time-lapse atomic force microscopy. International Conference on Cell and Molecular Biology of Alzheimer's Disease, Not Published: Not Published.
  • Cardoso, I., Goldsbury, C., Muller, S., Olivieri, V., Wirtz, S., Damas, A., Aebi, U., Saraiva, M. (2002). Transthyretin fibrillogenesis entails the assembly of monomers: a molecular model for in vitro assembled transthyretin amyloid-like fibrils. Journal of Molecular Biology, 317(5), 683-695.

2001

  • Goldsbury, C. (2001). Amyloid-Beta assembly into fibrils involves multiple pathways: Implications for inhibition strategies. The 9th International Symposium on Amyloidosis, Not Published: Not Published.
  • Goldsbury, C. (2001). Assessing the efficacy of amyloid fibril formation inhibitors using time-lapse AFM: potential therapeutic candidates for Alzheimer's disease. 27th Meeting of the Federation of European Biochemical Societies (FEBS), Not Published: Not Published.
  • Cardoso, I., Goldsbury, C., Aebi, U., Saraiva, M. (2001). Dynamics of TTR fibrils assembly: Leu55Pro fibrils formed at physiological pH versus WT fibrils produced by acidification. The 9th International Symposium on Amyloidosis, Not Published: Not Published.

Selected Grants

2022

  • Targeting TREM2 on microglia to modulate lipid metabolism and enhance remyelination in multiple sclerosis, Piccio L, Goldsbury C, Don A, Buckland M, Multiple Sclerosis Australia/Project Grant

2013

  • La Vision BioTec Ultramicroscope, Murphy C, Braet F, Byrne M, Chan-Ling T, Fraser S, Goldsbury C, Halliday G, Hambly B, Johnstone D, Keay K, Lovelace M, Lyons J, Mason R, Overall R, Owens T, Richardson D, Stone J, Weiss A, National Health and Medical Research Council (NHMRC)/Equipment Grant
  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility, Allbutt H, Ammit A, Assinder S, Bao B, Barrs V, Black J, Brennan-Speranza T, Buckland M, Burgess J, Byrne M, Camp A, Christopherson R, Codd R, Day M, de Graaf S, Dixon K, Dong Q, Dos Remedios C, Fraser S, Fu D, Goldsbury C, Groundwater P, Halliday G, Hambly B, Hardikar A, Hibbs D, Ho P, Hong A, Huang M, Huq F, Jansson P, Johnstone D, Joshua D, Ju Y, Kalinowski D, King N, Kovacevic Z, Kril J, Lai D, Lane D, Lay P, Lee C, Lok H, Lovicu F, Lu Z, Lyons J, Mason R, McLennan S, Morris B, Murphy C, Murray M, Naylor M, Oliver B, Owens T, Poronnik P, Rendina L, Richardson D, Ryan R, Sahni S, Scolyer R, Shafie N, Sharland A, Slobedman B, Sunde M, Sutherland G, Triccas J, Williamson P, Zhu L, Zreiqat H, National Health and Medical Research Council (NHMRC)/Equipment Grant