Dr Claire Goldsbury

Level C (Research Only) Academic
Brain & Mind Research Institute, School of Medical Sciences

Telephone +61 2 9351 0878
Fax +61 2 9351 0731

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Biographical details

Claire Goldsbury is a Senior Research Fellow and Group Leader at the BMRI. Her lab was established in July 2007 and comprises a team of Australian PhD and honours students and visiting international students. We collaborate with other groups in the wider University of Sydney and NSW community and internationally.

Selected grants

2014

  • La Vision BioTec Ultramicroscope; Murphy C, Braet F, Byrne M, Chan-Ling T, Fraser S, Goldsbury C, Halliday G, Hambly B, Johnstone D, Keay K, Lovelace M, Lyons G, Mason R, Overall R, Owens T, Richardson D, Stone J, Weiss A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • Leica PowerMosaic plus microsope upgrade for flexible, high-resolution slide scanning; Gamble J, McCaughan G, Feng C, Fazekas de St Groth B, Weninger W, Shackel N, Bertolino P, Lovelace M, Saunders B, Armati P, Pollard J, Pai S, Arnold J, Triccas J, Goldsbury C, Bailey C, Mrass P, Rasko J, Biro M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Wide field super-resolution microscopy with ground state depletion - Exploring nanoscopic life in chronic diseases; Braet F, Weiss A, King N, Dos Remedios C, Traini D, Graeber M, Murphy C, Grau G, Soon L, Newsome T, Goldsbury C, Lovelace M, Gorrell M, Pollock C; DVC Research/Equipment Grant.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2012

  • Novel auto-antibodies to nervous system antigens in paralyzing disorders; Goldsbury C, Mathey E; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2011

  • How Alzheimers-associated cytoskeletal inclusions form road blocks and impair trafficking in neurons; Goldsbury C; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Detection of brain/nerve reactive antibodies and causes of neuronal dysfunction in neurological disorders; Goldsbury C, Mathey E; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • A 5-D Correlative Imaging Platform: Combining the Strengths of Light and Electron Microscopy; Braet F, Mitchell H, Soon L, Overall R, Day D, Waterhouse P, Marc J, Conigrave A, Weiss A, Newsome T, Meikle S, Goetz J, Goldsbury C, Hambley T, Ramzan I, Young P, Traini D, Grewal T, Fleming S, Murphy C, Grau G, Weninger W, Dos Remedios C, Wimmer-Kleikamp S, Munroe P, Stevens-Kalceff M, Foster L, Killingsworth M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2009

  • Neuronal energy crisis in Alzheimers disease: Evidence from human neuropatholgy and cell culture models; Cullen K, Goldsbury C; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Pathogenic mechanisms of neuronal dysfunction and drug discovery for neurodegenerative diseases; Goldsbury C; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Mitochondrial Dysfunction as an initiator of Cytoskeletal Abnormalities in Alzhiemer's Disease; Whiteman I, Cullen K, Goldsbury C; Judith Jane Mason and Harold Stannett Williams Memorial Foundation/Medical and Scientific Research Grants.
  • Mitochondrial Dysfunction as an initiator of Cytoskeletal Abnormalities in Alzhiemers Disease; Goldsbury C; Judith Jane Mason and Harold Stannett Williams Memorial Foundation/Medical and Scientific Research Grants.
  • Energy Deficiency as a cause of neuritic pathology in AD; Goldsbury C; Sir Zelman Cowen Universities Fund/Research Support.

2006

  • University of Sydney - International Senior Research Fellow; Goldsbury C; University of Sydney/International Senior Research Fellow.

Selected publications

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Book Chapters

  • Goldsbury, C., Scheuring, S. (2003). Atomic Force Microscopy in biology. In John E. Coligan (Eds.), Current Protocols in Protein Science, (pp. 17.7.1-17.7.19). John Wiley & Sons.

Journals

  • Rahman, T., Davies, D., Tannenberg, R., Fok, S., Shepherd, C., Dodd, P., Cullen, K., Goldsbury, C. (2014). Cofilin rods and aggregates concur with tau pathology and the development of alzheimer's disease. Journal of Alzheimer's Disease, 42(4), 1443-1460. [More Information]
  • Acosta, J., Goldsbury, C., Winnick, C., Badrock, A., Fraser, S., Laird, A., Hall, T., Don, E., Fifita, J., Blair, I., Nicholson, G., Cole, N. (2014). Mutant Human FUS Is Ubiquitously Mislocalized and Generates Persistent Stress Granules in Primary Cultured Transgenic Zebrafish Cells. PloS One, 9(6), 1-9. [More Information]
  • Saberi, S., Du, Y., Christie, M., Goldsbury, C. (2013). Human Chorionic Gonadotropin Increases b-Cleavage of Amyloid Precursor Protein in SH-SY5Y Cells. Cellular and Molecular Neurobiology, 33(6), 747-751. [More Information]
  • Goldsbury, C., Baxa, U., Simon, M., Steven, A., Engel, A., Wall, J., Aebi, U., Mueller, S. (2011). Amyloid Structure and Assembly: Insights from Scanning Transmission Electron Microscopy. Journal of Structural Biology, 173(1), 1-13. [More Information]
  • Whiteman, I., Minamide, L., Goh, D., Bamburg, J., Goldsbury, C. (2011). Rapid Changes in Phospho-MAP/Tau Epitopes during Neuronal Stress: Cofilin-Actin Rods Primarily Recruit Microtubule Binding Domain Epitopes. PloS One, 6(6), e20878-1-e20878-12. [More Information]
  • Bamburg, J., Bernstein, B., Davis, R., Flynn, K., Goldsbury, C., Jensen, J., Maloney, M., Marsden, I., Minamide, L., et al (2010). ADF/Cofilin-actin rods in neurodegenerative diseases. Current Alzheimer Research, 7(3), 241-50. [More Information]
  • Whiteman, I., Gervasio, O., Cullen, K., Guillemin, G., Jeong, E., Witting, P., Antao, S., Minamide, L., Bamburg, J., Goldsbury, C. (2009). Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. The Journal of Neuroscience, 29(41), 12994-13005. [More Information]
  • Goldsbury, C., Scheuring, S., Kreplak, L. (2009). Introduction to atomic force microscopy (AFM) in biology. Current Protocols in Protein Science, , 17.7.1-17.7.19.
  • Goldsbury, C., Whiteman, I., Jeong, E., Lim, Y. (2008). Oxidative stress increases levels of endogenous amyloid-β peptides secreted from primary chick brain neurons. Aging Cell, 7(5), 771-775. [More Information]
  • Goldsbury, C., Thies, E., Konzack, S., Mandelkow, E. (2007). Quantification of Amyloid Precursor Protein and tau for the study of axonal traffic pathways. The Journal of Neuroscience, 27(13), 3357-3363. [More Information]
  • Goldsbury, C., Mocanu, M., Thies, E., Kaether, C., Haass, C., Keller, P., Biernat, J., Mandelkow, E., Mandelkow, E. (2006). Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides. Traffic: the international journal of intracellular transport, 7(7), 873-888. [More Information]
  • Goldsbury, C., Frey, P., Olivieri, V., Aebi, U., Mueller, S. (2005). Multiple assembly pathways underlie amyloid-β fibril polymorphisms. Journal of Molecular Biology, 352(2), 282-298. [More Information]
  • Goldsbury, C., Green, J. (2005). Time-lapse atomic force microscopy in the characterization of amyloid-like fibril assembly and oligomeric intermediates. Methods in Molecular Biology, 299, 103-128. [More Information]
  • Green, J., Kreplak, L., Goldsbury, C., Blatter, X., Stolz, M., Cooper, G., Seelig, A., Kistler, J., Aebi, U. (2004). Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide. Journal of Molecular Biology, 342(3), 877-887. [More Information]
  • Green, J., Goldsbury, C., Kistler, J., Cooper, G., Aebi, U. (2004). Human amylin oligomer growth and fibril elongation define two distinct phases in amyloid formation. Journal of Biological Chemistry, 279(13), 12206-12212.
  • Green, J., Goldsbury, C., Mini, T., Sunderji, S., Frey, P., Kistler, J., Cooper, G., Aebi, U. (2003). Full-length Rat Amylin Forms Fibrils Following Substitution of Single Residues from Human Amylin. Journal of Molecular Biology, 326(4), 1147-1156.
  • Cardoso, I., Goldsbury, C., Muller, S., Olivieri, V., Wirtz, S., Damas, A., Aebi, U., Saraiva, M. (2002). Transthyretin fibrillogenesis entails the assembly of monomers: a molecular model for in vitro assembled transthyretin amyloid-like fibrils. Journal of Molecular Biology, 317(5), 683-695.
  • Goldsbury, C., Aebi, U., Frey, P. (2001). Visualizing the growth of Alzheimer's Abeta amyloid-like fibrils. Trends in Molecular Medicine, 7(12), 582.

Conferences

  • Goldsbury, C., Aebi, U., Frey, P. (2007). Assembly and structure of Alzheimer's A-beta amyloid-like fibrils. American Society for Cell Biology Meeting.
  • Goldsbury, C. (2007). Quantification of the amyloid precursor protein and tau for the study of axonal trafficking pathways. International Brain Research Organisation World Congress of Neuroscience.
  • Goldsbury, C. (2006). Is amyloid-beta generation linked to axonal transport of APP? The sixth Eibsee Meeting, Not Published: Not Published.
  • Goldsbury, C. (2006). Linkage of axonal transport and generation of amyloid-beta peptides. The 10th International Conference on Alzheimer's Disease and Related Disorders, Not Published: Not Published.
  • Goldsbury, C. (2002). Tracking assembly and structure of amyloid-beta fibrils by time-lapse atomic force microscopy. International Conference on Cell and Molecular Biology of Alzheimer's Disease, Not Published: Not Published.
  • Goldsbury, C. (2001). Amyloid-Beta assembly into fibrils involves multiple pathways: Implications for inhibition strategies. The 9th International Symposium on Amyloidosis, Not Published: Not Published.
  • Goldsbury, C. (2001). Assessing the efficacy of amyloid fibril formation inhibitors using time-lapse AFM: potential therapeutic candidates for Alzheimer's disease. 27th Meeting of the Federation of European Biochemical Societies (FEBS), Not Published: Not Published.
  • Cardoso, I., Goldsbury, C., Aebi, U., Saraiva, M. (2001). Dynamics of TTR fibrils assembly: Leu55Pro fibrils formed at physiological pH versus WT fibrils produced by acidification. The 9th International Symposium on Amyloidosis, Not Published: Not Published.
  • Green, J., Aebi, U., Kistler, J., Cooper, G., Goldsbury, C. (2001). Investigating early steps in human amylin fibril formation. The 9th International Symposium on Amyloidosis, Not Published: Not Published.
  • Green, J., Goldsbury, C., Kistler, J., Aebi, U., Cooper, G. (2001). Investigating the amino acid residues in the human amylin peptide required for fibril formation. American Society for Cell Biology Meeting.

2014

  • Rahman, T., Davies, D., Tannenberg, R., Fok, S., Shepherd, C., Dodd, P., Cullen, K., Goldsbury, C. (2014). Cofilin rods and aggregates concur with tau pathology and the development of alzheimer's disease. Journal of Alzheimer's Disease, 42(4), 1443-1460. [More Information]
  • Acosta, J., Goldsbury, C., Winnick, C., Badrock, A., Fraser, S., Laird, A., Hall, T., Don, E., Fifita, J., Blair, I., Nicholson, G., Cole, N. (2014). Mutant Human FUS Is Ubiquitously Mislocalized and Generates Persistent Stress Granules in Primary Cultured Transgenic Zebrafish Cells. PloS One, 9(6), 1-9. [More Information]

2013

  • Saberi, S., Du, Y., Christie, M., Goldsbury, C. (2013). Human Chorionic Gonadotropin Increases b-Cleavage of Amyloid Precursor Protein in SH-SY5Y Cells. Cellular and Molecular Neurobiology, 33(6), 747-751. [More Information]

2011

  • Goldsbury, C., Baxa, U., Simon, M., Steven, A., Engel, A., Wall, J., Aebi, U., Mueller, S. (2011). Amyloid Structure and Assembly: Insights from Scanning Transmission Electron Microscopy. Journal of Structural Biology, 173(1), 1-13. [More Information]
  • Whiteman, I., Minamide, L., Goh, D., Bamburg, J., Goldsbury, C. (2011). Rapid Changes in Phospho-MAP/Tau Epitopes during Neuronal Stress: Cofilin-Actin Rods Primarily Recruit Microtubule Binding Domain Epitopes. PloS One, 6(6), e20878-1-e20878-12. [More Information]

2010

  • Bamburg, J., Bernstein, B., Davis, R., Flynn, K., Goldsbury, C., Jensen, J., Maloney, M., Marsden, I., Minamide, L., et al (2010). ADF/Cofilin-actin rods in neurodegenerative diseases. Current Alzheimer Research, 7(3), 241-50. [More Information]

2009

  • Whiteman, I., Gervasio, O., Cullen, K., Guillemin, G., Jeong, E., Witting, P., Antao, S., Minamide, L., Bamburg, J., Goldsbury, C. (2009). Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations. The Journal of Neuroscience, 29(41), 12994-13005. [More Information]
  • Goldsbury, C., Scheuring, S., Kreplak, L. (2009). Introduction to atomic force microscopy (AFM) in biology. Current Protocols in Protein Science, , 17.7.1-17.7.19.

2008

  • Goldsbury, C., Whiteman, I., Jeong, E., Lim, Y. (2008). Oxidative stress increases levels of endogenous amyloid-β peptides secreted from primary chick brain neurons. Aging Cell, 7(5), 771-775. [More Information]

2007

  • Goldsbury, C., Aebi, U., Frey, P. (2007). Assembly and structure of Alzheimer's A-beta amyloid-like fibrils. American Society for Cell Biology Meeting.
  • Goldsbury, C., Thies, E., Konzack, S., Mandelkow, E. (2007). Quantification of Amyloid Precursor Protein and tau for the study of axonal traffic pathways. The Journal of Neuroscience, 27(13), 3357-3363. [More Information]
  • Goldsbury, C. (2007). Quantification of the amyloid precursor protein and tau for the study of axonal trafficking pathways. International Brain Research Organisation World Congress of Neuroscience.

2006

  • Goldsbury, C., Mocanu, M., Thies, E., Kaether, C., Haass, C., Keller, P., Biernat, J., Mandelkow, E., Mandelkow, E. (2006). Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides. Traffic: the international journal of intracellular transport, 7(7), 873-888. [More Information]
  • Goldsbury, C. (2006). Is amyloid-beta generation linked to axonal transport of APP? The sixth Eibsee Meeting, Not Published: Not Published.
  • Goldsbury, C. (2006). Linkage of axonal transport and generation of amyloid-beta peptides. The 10th International Conference on Alzheimer's Disease and Related Disorders, Not Published: Not Published.

2005

  • Goldsbury, C., Frey, P., Olivieri, V., Aebi, U., Mueller, S. (2005). Multiple assembly pathways underlie amyloid-β fibril polymorphisms. Journal of Molecular Biology, 352(2), 282-298. [More Information]
  • Goldsbury, C., Green, J. (2005). Time-lapse atomic force microscopy in the characterization of amyloid-like fibril assembly and oligomeric intermediates. Methods in Molecular Biology, 299, 103-128. [More Information]

2004

  • Green, J., Kreplak, L., Goldsbury, C., Blatter, X., Stolz, M., Cooper, G., Seelig, A., Kistler, J., Aebi, U. (2004). Atomic force microscopy reveals defects within mica supported lipid bilayers induced by the amyloidogenic human amylin peptide. Journal of Molecular Biology, 342(3), 877-887. [More Information]
  • Green, J., Goldsbury, C., Kistler, J., Cooper, G., Aebi, U. (2004). Human amylin oligomer growth and fibril elongation define two distinct phases in amyloid formation. Journal of Biological Chemistry, 279(13), 12206-12212.

2003

  • Goldsbury, C., Scheuring, S. (2003). Atomic Force Microscopy in biology. In John E. Coligan (Eds.), Current Protocols in Protein Science, (pp. 17.7.1-17.7.19). John Wiley & Sons.
  • Green, J., Goldsbury, C., Mini, T., Sunderji, S., Frey, P., Kistler, J., Cooper, G., Aebi, U. (2003). Full-length Rat Amylin Forms Fibrils Following Substitution of Single Residues from Human Amylin. Journal of Molecular Biology, 326(4), 1147-1156.

2002

  • Goldsbury, C. (2002). Tracking assembly and structure of amyloid-beta fibrils by time-lapse atomic force microscopy. International Conference on Cell and Molecular Biology of Alzheimer's Disease, Not Published: Not Published.
  • Cardoso, I., Goldsbury, C., Muller, S., Olivieri, V., Wirtz, S., Damas, A., Aebi, U., Saraiva, M. (2002). Transthyretin fibrillogenesis entails the assembly of monomers: a molecular model for in vitro assembled transthyretin amyloid-like fibrils. Journal of Molecular Biology, 317(5), 683-695.

2001

  • Goldsbury, C. (2001). Amyloid-Beta assembly into fibrils involves multiple pathways: Implications for inhibition strategies. The 9th International Symposium on Amyloidosis, Not Published: Not Published.
  • Goldsbury, C. (2001). Assessing the efficacy of amyloid fibril formation inhibitors using time-lapse AFM: potential therapeutic candidates for Alzheimer's disease. 27th Meeting of the Federation of European Biochemical Societies (FEBS), Not Published: Not Published.
  • Cardoso, I., Goldsbury, C., Aebi, U., Saraiva, M. (2001). Dynamics of TTR fibrils assembly: Leu55Pro fibrils formed at physiological pH versus WT fibrils produced by acidification. The 9th International Symposium on Amyloidosis, Not Published: Not Published.
  • Green, J., Aebi, U., Kistler, J., Cooper, G., Goldsbury, C. (2001). Investigating early steps in human amylin fibril formation. The 9th International Symposium on Amyloidosis, Not Published: Not Published.
  • Green, J., Goldsbury, C., Kistler, J., Aebi, U., Cooper, G. (2001). Investigating the amino acid residues in the human amylin peptide required for fibril formation. American Society for Cell Biology Meeting.
  • Goldsbury, C., Aebi, U., Frey, P. (2001). Visualizing the growth of Alzheimer's Abeta amyloid-like fibrils. Trends in Molecular Medicine, 7(12), 582.

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