Professor Des Richardson
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Professor of Cancer Cell Biology/NHMRC Senior Principal Research Fellow
D06 - Blackburn Building |
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Themes | Research interests | Grants | PhD & Masters' project opportunities | Honours project opportunities | Keywords
Research interests
Professor Richardson’s major contributions to cancer research are focussed on understanding the role of iron in cancer cell proliferation and the development of novel anti-tumour agents known as iron chelators. Indeed, these studies have resulted in highly promising and potent anti-cancer drugs and are subject of a suite of active national patents.
Current national competitive grants*
2012
Pre-clinical Development of a Novel Second Generation Chemotherapeutic for Cancer Therapy
Richardson D, Lovejoy D, Mills J
NHMRC Development Grants ($570,000 over 2 years)
Pharmacology of potential anti-tumour agents: Iron and copper chelators of the ApT, BpT and DpT classes
Richardson D, Lovejoy D, Brunk U
NHMRC Project Grants ($624,685 over 3 years)
2011
Development of iron complexes for the treatment of Friedreich's Ataxia
Richardson D, Ponka P
Muscular Dystrophy Association (USA) Research Support ($450,000 over 3 years)
Development of Iron Complexes for the Treatment of Friedreich?s Ataxia & the Role of Frataxin in Iron Metabolism
Richardson D, Suryo Rahmanto Y, Ponka P
National Health and Medical Research Council Project Grant ($595,048 over 3 years)
2010
Pharmacological Targeting via AKT, PTEN, and TGF-beta Pathway Integration using Novel Therapeutics
Richardson D, Assinder S, Dong Q
NHMRC Project Grant ($611,875 over 3 years)
Alpha-2-macroglobulin and the transport and uptake of the hormone, hepcidin
Richardson D, Suryo Rahmanto Y, Kuchel P
NHMRC Project Grant ($514,500 over 3 years)
The Effect of Nitrogen Monoxide on Intracellular Iron Metabolism
Richardson D
ARC Discovery Project ($540,000 over 3 years)
2009
Senior Principal Research Fellowship
Richardson D
NHMRC Research Fellowship ($766,250 over 5 years)
* Grants administered through the University of Sydney
PhD and Masters' project opportunities
Medicinal Chemistry and Biology - Development of Novel Anti-Tumour Agents for Cancer Treatment
Honours project opportunities
Development of New Iron Chelators as Novel Drugs Against Cancer
Transport of nitric oxide in cells and its interaction with iron containing proteins in tumour cells
Investigating cellular response to iron-depletion by examining the mitogen-activated protein kinases (MAPK) signalling pathway
The Role of Iron in the Pathogenesis of the Crippling Neurodegenerative Disease, Friedreich's Ataxia
The role of ascorbate in modulating hypoxic signalling in iron metabolism
The role of GPI-linked ceruloplasmin in astrocyte iron metabolism
Molecular regulation of ERp29 in epithelial cancer cell plasticity
Dissecting the role of NDRG-1 in regulating endoplasmic reticulum stress and cancer cell survival
The Role of Melanotransferrin in Melanoma Growth and Metastasis
Molecular Regulation of eIF3a in Cancer Cell Motility and Invasion
Examining the Molecular Mechanisms Behind the Anti-Tumour Activity of NDRG1 in Pancreatic Cancer