2025

• Ni, K., Liu, Y., Di, P., Wang, L., Huang, H., Holsinger, D., Kiang, K., Jiao, J. (2025). Chromobox protein homolog 7 suppresses the stem-like phenotype of glioblastoma cells by regulating the myosin heavy chain 9-NF-κB signaling pathway. Cell Death Discovery, 11(1), 1-16. [More Information]

2024

• Huynh, Q., Holsinger, D. (2024). Development of a Cell Culture Chamber for Investigating the Therapeutic Effects of Electrical Stimulation on Neural Growth. Biomedicines, 12(2). [More Information]

2023

• Elangovan, S., Borody, T., Holsinger, D. (2023). Fecal Microbiota Transplantation Reduces Pathology and Improves Cognition in a Mouse Model of Alzheimer's Disease. Cells, 12(1). [More Information]
• Holsinger, D. (2023). Guest Editor Special Issue "Molecular Insights into Neurodegenerative Diseases". Cells, 12. [More Information]
• Holsinger, D. (2023). Guest Editor Special Issue "Therapeutic Agents for Neurological Disorders 2023". Pharmaceuticals, 16. [More Information]
• Holsinger, D. (2023). Guest Editor Special Issue "Therapeutic Approaches for Neurodegenerative Diseases". Frontiers in Aging Neuroscience. [More Information]
• Olufunmilayo, E., Holsinger, D. (2023). INPP5D/SHIP1: Expression, Regulation and Roles in Alzheimer’s Disease Pathophysiology. Genes, 14(10), 1845. [More Information]
• Mirza, F., Zahid, S., Holsinger, D. (2023). Neuroprotective Effects of Carnosic Acid: Insight into its Mechanisms of Action. Molecules, 28(5), 2306. [More Information]
• Olufunmilayo, E., Gerke, M., Holsinger, D. (2023). Oxidative Stress and Antioxidants in Neurodegenerative Disorders. Antioxidants, 12(2), 517. [More Information]
• Olufunmilayo, E., Holsinger, D. (2023). Roles of Non-Coding RNA in Alzheimer's Disease Pathophysiology. International Journal of Molecular Sciences, 24(14), 12498. [More Information]
• Matheson, J., Holsinger, D. (2023). The Role of Fecal Microbiota Transplantation in the Treatment of Neurodegenerative Diseases: A Review. International Journal of Molecular Sciences, 24(2), 1001. [More Information]

2022

• Huynh, Q., Elangovan, S., Holsinger, D. (2022). Non-Pharmacological Therapeutic Options for the Treatment of Alzheimer's Disease. International Journal of Molecular Sciences, 23, 11037. [More Information]
• Olufunmilayo, E., Holsinger, D. (2022). Variant TREM2 Signaling in Alzheimer's Disease. Journal of Molecular Biology, 434(7), 167470. [More Information]

2021

• Kwasi, V., Niwa, R., Hara, T., Holsinger, D. (2021). Diagnostic Conundrums in Cerebellar Cryptic Arteriovenous Malformations. Journal of Neurology and Neuroscience, 12(5), 368.
• Moylan, C., Cao, T., Huynh, Q., Pratap, A., Holsinger, D. (2021). Exercise-Induced Alterations in TrkB expression in the 5XFAD Mouse Model of Alzheimer's Disease. Alzheimer's and Dementia, 17, e058733. [More Information]
• Rahman, M., Islam, T., Shahjaman, M., Rana, M., Holsinger, D., Quinn, J., Gov, E., Moni, M. (2021). Genome-Wide Integrative Analysis Reveals Common Molecular Signatures in Blood and Brain of Alzheimer's Disease. Biointerface Research in Applied Chemistry, 11(2), 8686-8701. [More Information]
• Paasila, P., Fok, S., Flores-Rodriguez, N., Sajjan, S., Svahn, A., Dennis, C., Holsinger, D., Kril, J., Becker, T., Banati, R., Sutherland, G., Graeber, M. (2021). Ground state depletion microscopy as a tool for studying microglia-synapse interactions. Journal of Neuroscience Research, 99(6), 1515-1532. [More Information]
• Holsinger, D. (2021). Guest Editor Special Issue "Therapeutic Agents for Neurological Disorders 2022". Pharmaceuticals, 2. [More Information]
• Huynh, Q., Holsinger, D. (2021). Regenerating spiral ganglion neurons employing the cochlear implant. Alzheimer's and Dementia, 17, e058565. [More Information]

2020

• Pratap, A., Holsinger, D. (2020). Altered Brain Adiponectin Receptor Expression in the 5XFAD Mouse Model of Alzheimer's Disease. Pharmaceuticals, 13(7), 1-13. [More Information]
• Pratap, A., Holsinger, D. (2020). Altered Brain Leptin and Leptin Receptor Expression in the 5XFAD Mouse Model of Alzheimer's Disease. Pharmaceuticals, 13(11), 1-15. [More Information]
• Elangovan, S., Holsinger, D. (2020). Cyclical amyloid beta-astrocyte activity induces oxidative stress in Alzheimer's disease. Biochimie, 171-172, 38-42. [More Information]
• Holsinger, D. (2020). Guest Editor Special Issue "Therapeutic Agents for Neurological Disorders". Pharmaceuticals, 13(4), 1-1. [More Information]
• Rahman, M., Islam, T., Zaman, T., Shahjaman, M., Karim, M., Huq, F., Quinn, J., Holsinger, D., Gov, E., Moni, M. (2020). Identification of molecular signatures and pathways to identify novel therapeutic targets in Alzheimer's disease: Insights from a systems biomedicine perspective. Genomics, 112(2), 1290-1299. [More Information]
• Gaukas, N., Huynh, Q., Pratap, A., Einarsrud, M., Grande, T., Holsinger, D., Glaum, J. (2020). In Vitro Biocompatibility of Piezoelectric K05Na05NbO3 Thin Films on Platinized Silicon Substrates. ACS Applied Bio Materials, 3(12), 8714-8721. [More Information]
• Banati, R., Wilcox, P., Xu, R., Yin, G., Si, E., Son, E., Shimizu, M., Holsinger, D., Parmar, A., Zahra, D., Liu, G., Graeber, M., et al (2020). Selective, high-contrast detection of syngeneic glioblastoma in vivo. Scientific Reports, 10(1), 9968. [More Information]
• Banati, R., Wilcox, P., Xu, R., Yin, G., Si, E., Son, E., Shimizu, M., Holsinger, D., Parmar, A., Zahra, D., Liu, G., Graeber, M., et al (2020). Selective, high-contrast detection of syngeneic glioblastoma in vivo (Erratum). Scientific Reports, 10(1), 9968. [More Information]

2018

• Buljan, V., Graeber, M., Holsinger, D., Brown, D., Hambly, B., Delikatny, E., Vuletic, V., Krebs, X., Tomas, I., Bohorquez-Florez, J., Banati, R., et al (2018). Calcium-axonemal microtubuli interactions underlie mechanism(s) of primary cilia morphological changes. Journal of Biological Physics, 44(1), 53-80. [More Information]
• Wang, R., Holsinger, D. (2018). Exercise-Induced Brain-Derived Neurotrophic Factor Expression: Therapeutic Implications for Alzheimer's Dementia. Ageing Research Reviews, 48, 109-121. [More Information]
• Porto, R., Dutra, F., Crestani, A., Holsinger, D., Quillfeldt, J., de Bittencourt, P., de Oliveira Alvares, L. (2018). HSP70 Facilitates Memory Consolidation of Fear Conditioning through MAPK Pathway in the Hippocampus. Neuroscience, 375(April), 108-118. [More Information]
• Elangovan, S., Holsinger, D. (2018). Personalized Medicine in Neurodegenerative Diseases. Source Journal of Neurological Disorders and Therapies, 11, 1-11.

2017

• Kosaraju, J., Holsinger, D., Guo, L., Tam, K. (2017). Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease. Molecular Neurobiology, 54(8), 6074-6084. [More Information]

2016

• Rollo, J., Banihashemi, N., Vafaee, F., Crawford, J., Kuncic, Z., Holsinger, D. (2016). Unraveling the mechanistic complexity of Alzheimer's disease through systems biology. Alzheimer's and Dementia, 12(6), 708-718. [More Information]

2015

• Holsinger, D. (2015). Translation of low-risk dementia-associated interventions into practice- a call to action. Healthy Aging Research, 4(30), 1-9. [More Information]

2014

• Thompson, G., Ireland, T., Larkin, X., Arnold, J., Holsinger, D. (2014). A Novel Segmentation-Based Algorithm for the Quantification of Magnified Cells. Journal Of Cellular Biochemistry, 115, 1849-1854. [More Information]
• Buljan, V., Holsinger, D., Hambly, B., Kanellis, V., Matar, E., Larkin, X., Liu, G., Bohorquez-Florez, J., Banati, R. (2014). Intrinsic synergistic-topological mechanism versus synergistic-topological matrix in microtubule self-organization. EPJ Nonlinear Biomedical Physics, 2, 1-28. [More Information]
• Sajjan, S., Holsinger, D., Fok, S., Ebrahimkhani, S., Rollo, J., Banati, R., Graeber, M. (2014). Up-regulation of matrix metallopeptidase 12 in motor neurons undergoing synaptic stripping. Neuroscience, 274, 331-340. [More Information]

2013

• Holsinger, D., Petersen, G., Hilbert, B., Strappe, P. (2013). Generation of induced neuronal cells from adult stem cells for tissue engineering applications by lentiviral vector expression of transcription factors. Australian Society of Biomaterials and Tissue Engineering (ASBTE), Tanunda, Barossa Valley, South Australia: ASBTE.
• Buljan, V., Holsinger, D., Hambly, B., Banati, R., Ivanova, E. (2013). Intrinsic microtubule GTP-cap dynamics in semi-confined systems: kinetochore-microtubule interface. Journal of Biological Physics, 39(1), 81-98. [More Information]
• Kosaraju, J., Gali, C., Khatwal, R., Dubala, A., Chinni, S., Holsinger, D., Madhunapantula, V., Nataraj, S., Basavan, D. (2013). Saxagliptin: A dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease. Neuropharmacology, 72, 291-300. [More Information]
• Buljan, V., Holsinger, D., Brown, D., Bohorquez-Florez, J., Hambly, B., Delikatny, E., Ivanova, E., Banati, R. (2013). Spinodal decomposition and the emergence of dissipative transient periodic spatio-temporal patterns in acentrosomal microtubule multitudes of different morphology. Chaos, 23(2), 1-16. [More Information]
• Holsinger, D., Goense, N., Bohorquez-Florez, J., Strappe, P. (2013). Splice variants of the Alzheimer's disease beta-secretase, BACE1. Neurogenetics, 14(1), 1-9. [More Information]
• Li, W., Holsinger, D., Kruse, C., Flugel, A., Graeber, M. (2013). The Potential for Genetically Altered Microglia to Influence Glioma Treatment. CNS & Neurological Disorders - Drug Targets, 12(6), 750-762. [More Information]

2012

• Holsinger, D., Chua, Y., Goense, N., Alomari, M., Rao, G., Bohorquez, J., Chen, Y. (2012). A novel BACE1-regulating protein with therapeutic potential. Alzheimer’s Association Internatonal Conference 2012, Vancouver, Canada.: Alzheimer’s Association Internatonal Conference 2012.
• Holsinger, D., Li, W., Graeber, M. (2012). Microglia as a therapeutic target in glioma. Personalised Medicine Workshop - HMRI, University of Newcastle NSW: Personalised Medicine Workshop HMRI.
• Holsinger, D., Brown, R., Richmond, R., Kay-Lambkin, F., Kirby, A., Chan, D. (2012). Prevalence of the long-allele genotype of the serotonin transporter-linked gene in female centenarians. Journal of the American Geriatrics Society, 60(9), 1786-1788. [More Information]
• Holsinger, D., Li, W., Garebar, M. (2012). The need for multidimensional tissue analysis: Alzheimer's disease as an example. Biomarker Discovery Conference 2012, Shoal Bay NSW: Biomarker Discovery Conference 2012.

2010

• George, A., Gordon, L., Beissbarth, T., Koukoulas, I., Holsinger, D., Perreau, V., Cappai, R., Tan, S., Masters, C., Scott, H., et al (2010). A Serial Analysis of Gene Expression Profile of the Alzheimer's Disease Tg2576 Mouse Model. Neurotoxicity Research, 17(4), 360-379. [More Information]

2009

• Kassiou, M., Banati, R., Holsinger, D., Meikle, S. (2009). Challenges in molecular imaging of Parkinson's disease: A brief overview. Brain Research Bulletin, 78(2-3), 105-108. [More Information]

2008

• Holsinger, D., Alomari, M. (2008). An endogenous regulator decreases levels of the Alzheimer’s disease BACE1. Society of Neuroscience Abstract, Washington DC USA: Society of Neuroscience Abstract.
• Einfeld, S., Goetz, J., Holsinger, D. (2008). Pathogenetic mechanisms in Down Syndrome. Journal of Intellectual Disability Research, 52(10), 813-813. [More Information]
• Einfeld, S., Goetz, J., Holsinger, R. (2008). Two novel genes associated with Down's syndrome. Journal of Intellectual Disability Research, 52(10), 813.

2006

• George, A., Gordon, L., Beissbarth, T., Koukoulase, L., Holsinger, R., Perreaua, V., Cappai, R., Tan, S., Masters, C., Scott, H., et al (2006). A Serial Analysis of Gene Expression (SAGE) profile of the Alzheimer’s disease Tg2576 mouse model. The 10th International Conference on Alzheimer’s Disease and Related Disorders, Madrid, Spain: The 10th International Conference on Alzheimer’s Disease and Related Disorders.
• White, A., Du, T., Laughton, K., Volitakis, I., Sharples, R., Hoke, D., Holsinger, R., Evin, G., Cherny, R., Hill, A., et al (2006). Clioquinol induces metal-dependent degradation of the Alzheimer's disease amyloid beta peptide by up-regulation of matrix metalloproteases. Journal of Neurochemistry, 98(90).
• Holsinger, D., Lee, J., Boyd, A., Masters, C., Collins, S. (2006). CSF BACE1 activity is increased in CJD and Alzheimer disease other dementias. Neurology, 67(4), 710-712. [More Information]
• George, A., Holsinger, D., McLean, C., Tan, S., Scott, H., Cardamone, T., Cappai, R., Masters, C., Li, Q. (2006). Decreased phosphatidylethanolamine binding protein expression correlates with Aβ accumulation in the Tg2576 mouse model of Alzheimer's disease. Neurobiology of Aging, 27(4), 614-623. [More Information]
• White, A., Du, T., Laughton, K., Volitakis, I., Sharples, R., Xilinas, M., Hoke, D., Holsinger, D., Evin, G., Cherny, R., et al (2006). Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity. Journal of Biological Chemistry, 281(26), 17670-17680. [More Information]
• Beckman, M., Holsinger, D., Small, D. (2006). Heparin activates beta-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme. Biochemistry, 45(21), 6703-6714. [More Information]
• Small, D., Holsinger, R., Beckman, M. (2006). Heparin activates β-secertase (BACE1) of Alzheimer’s disease and increases autocatalysis of the enzyme. The 10th International Conference on Alzheimer’s Disease and Related Disorders, Madrid, Spain: The 10th International Conference on Alzheimer’s Disease and Related Disorders.

2005

• Mok, S., Holsinger, R., Li, Q., Cappai, R., Masters, C., Culvenor, J. (2005). Alpha-synuclein mutations increase sensitivity of human neuroblastoma cells to cytotoxicity. Journal of Neurochemistry, 94, 118-118.
• Mok, S., Holsinger, R., Li, Q., Cappai, R., Masters, C., Culvenor, J. (2005). Effect of pathogenic alpha-synucleain mutations on sensitivity of human neuroblastoma cells to toxicity. 7th International Conference AD/PD, Sorrento, Italy: 7th International Conference AD/PD.
• Holsinger, R., Saez-Valero, J., Lee, J., Collins, S., Masters, C., Evin, G. (2005). Evaluating BACE 1 as a diagnostic marker for Alzheimer’s disease. 7th International Conference AD/PD, Sorrento, Italy: 7th International Conference AD/PD.
• Chua, Y., Helfenbaum, L., Masters, C., Evin, G., Holsinger, R. (2005). Identification of Proteins Interacting with the Alzheimer’s Disease β-secretase Enzyme, BACE1. Society of Neuroscience Abstract, Washington DC USA: Society of Neuroscience Abstract.
• White, A., Du, T., Hill, A., Sharples, R., Barnham, K., Holsinger, R., Ciccotosto, G., Hoke, D., Evin, G., Laughton, K., et al (2005). Modulation of APP and Aβ metabolism by metal chelators. ISN and ESN 20th Biennial Meeting, Insbruck, Austria: ISN and ESN 20th Biennial Meeting.
• Holsinger, R., Tan, N., Masters, C., Evin, G., Tan, J. (2005). Suppression of the Alzheimer’s disease BACE1 by RNA interference. Society of Neuroscience Abstract, Washington DC USA: Society of Neuroscience Abstract.

2004

• Holsinger, R., McLean, C., Masters, C., Evin, G. (2004). Analysis of BACE protein and activity in human cerebrospinal fluid. Neurobiology of Aging, 25, 528-528.
• George, A., Holsinger, D., McLean, C., Laughton, K., Beyreuther, K., Evin, G., Masters, C., Li, Q. (2004). APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease. Neurobiology of Disease, 16(1), 124-132. [More Information]
• George, A., Holsinger, R., McLean, C., Laughton, K., Evin, G., Masters, C., Li, Q. (2004). Dietary cholesterol regulates APP processing in the Alzheimer's transgenic mouse model. Australian Neuroscience Society, Melbourne, Victoria Australia: Australian Neuroscience Society.
• Evin, G., Canterford, L., Hoke, D., Holsinger, R., Culvenor, J., Masters, C. (2004). Gamma-secretase inhibitors stabilize a 900 KDA presenilin complex: A tetrameric model for gamma-secretase. Neurobiology of Aging, 25, 558-558. [More Information]
• Holsinger, D., McLean, C., Collins, S., Masters, C., Evin, G. (2004). Increased β-secretase activity in cerebrospinal fluid of Alzheimer's disease subjects. Annals of Neurology, 55(6), 898-899. [More Information]

2003

• Evin, G., Canterford, L., Holsinger, R., Masters, C. (2003). Analysis of Alzheimer's Disease gamma-Secretase Complex Using Biotinylated Inhibitors. International Conference on Aspartic Proteases and Inhibitors, Kyoto, Japan.: International Conference on Aspartic Proteases and Inhibitors.
• Holsinger, R., Chua, Y., Masters, C., Evin, G. (2003). Detection of the Alzheimer’s disease β secretase enzyme, BACE, using different extraction techniques. Society for Neuroscience Abstracts 2003, New Orleans, USA: Society for Neuroscience Abstract.
• Evin, G., Culvenor, J., Sernee, M., Hoke, D., Canterford, L., Holsinger, R., Cappai, R., Beyreuther, K., Masters, C. (2003). Gamma-secretase processing of APP transmembravpmne domain. 6th International Conference AD/PD, Seville, Spain: 6th International Conference AD/PD.
• Evin, G., Zhu, A., Holsinger, D., Masters, C., Li, Q. (2003). Proteolytic processing of the Alzheimer's Disease amyloid precursor protein in brain and platelets. Journal of Neuroscience Research, 74, 386-392. [More Information]
• Holsinger, R., Cullen, K., Culvenor, J., Roytta, K., Canterford, L., Masters, C., Evin, G. (2003). Redefinition of BACE1 transmembrane domain to include residues 455-460. International Conference on Aspartic Proteases and Inhibitors, Kyoto, Japan.: International Conference on Aspartic Proteases and Inhibitors.
• Holsinger, R., Cullen, K., Culvenor, J., Roytta, K., Masters, C., Evin, G. (2003). Redefinition of BACE1 transmembrane domain to include residues 455-460. 28th Lorne Conference on Protein Structure and Function, Victoria, Australia: 28th Lorne Conference on Protein Structure and Function.
• George, A., Holsinger, R., McLean, C., Laughton, K., Beyreuther, K., Evin, G., Masters, C., Li, Q. (2003). Regulation of APP processing in the Alzheimer’s transgenic mouse model with diet-induced hypercholesterolemia. Combio 2003 ASBMB, Melbourne, Australia: Combio 2003 ASBMB.

2002

• Evin, G., Holsinger, R., Canterford, L., Hoke, D., Masters, C., Eggert, S., Weidemann, A., Beyreuther, K. (2002). APP C-terminal fragments in Alzheimer's disease brain. Neurobiology of Aging, 23(1), 656.
• Holsinger, R., McLean, C., Masters, C., Evin, G., Beyreuther, K. (2002). BACE and beta-secretase product CTF beta are increased in sporadic Alzheimer's disease brain. Neurobiology of Aging, 23(1), 663.
• Evin, G., Holsinger, R., Eggert, S., Weidmann, A., Canterford, L., Hoke, D., Gandy, S., McLean, C., Beyreuther, K., Masters, C. (2002). Carboxyl-terminal fragments of the amyloid precursor protein in Alzheimer's disease brain: detection of γ-secretase products. Brain Aging International Journal, 29(3), 61-66.
• Holsinger, D., McLean, C., Beyreuther, K., Masters, C., Evin, G. (2002). Increased expression of the amyloid precursor beta secretase in Alzheimer's Disease. Annals of Neurology, 51(6), 783-786. [More Information]
• Evin, G., Sernee, M., Barnham, K., Holsinger, R., Culvenor, J., Hoke, D., Li, Q., et al (2002). Modulation of Alzheimer's disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds. In K. Iqbal and B Winblad (Eds.), Alzheimer’s disease and related disorders: Research advances, (pp. 513-523). Bucharest, Romania: "Ana Alsan" International Academy of Aging.
• Fahnestock, M., Garzon, D., Holsinger, D., Michalski, B. (2002). Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule? Journal of Neural Transmission, 62(suppl.), 239-252.

2001

• Evin, G., Sharples, R., Weidemann, A., Reinhard, F., Carbone, V., Culvenor, J., Holsinger, D., Sernee, M., Beyreuther, K., Masters, C. (2001). Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease. Biochemistry, 62, 239-250.
• Holsinger, R., McLean, C., Beyreuther, K., Masters, C., Evin, G. (2001). Increased BACE Immunoreactivity in Alzheimer’s Disease Brain. Society for Neuroscience Abstract 2001, San Diego, USA: Society for Neuroscience Abstract 2001.

2000

• Holsinger, R., Schnarr, J., Henry, P., Castelo, V., Fahnestock, M. (2000). Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Molecular Brain Research, 76(2), 347-354.
• Holsinger, R., Cappai, R., McLean, C., Smith, M., Reinhard, F., Multhaup, G., Weidemann, A., Beyreuther, K., Masters, C., Evin, G. (2000). Quantitative analysis of BACE1 in normal and Alzheimer’s disease brain. Society for Neuroscience Abstract 2000, New Orleans USA: Society for Neuroscience Abstract 2000.