Dr Daniel Brown

Research Fellow in Meniere's Disease
Surgery, Central Clinical School

Telephone +61 2 9351 0748
Fax +61 2 9351 0855

Curriculum vitae Curriculum vitae

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Research interests

Dr Brown’s current research involves determining the cause of Ménière’s disease, and the development of a cure. He has developed the first laboratory fully devoted to research into Ménière’s disease with funds raised by Ménière’s Research Fund Incorporated, and located in The Brain & Mind Research Institute.

Dr Brown has a broader interest in sensory electrophysiology, neuroscience and homeostasis, and the development of tools for clinical and experimental diagnosis.

International links

Italy

(MSA ENT Academy) Research COllaboration

United States

(Washington University, School of Medicine. Dept. of Otolaryngology) Sponsored Postdoctoral Fellowship

Selected grants

2015

  • Morphological changes in Membranous Labyrinth of Menieres Disease compared to Animal Models; Mukherjee P, Brown D, Morey A, Curthoys I, Gibson W, Biggs D, Flanagan D; Garnett Passe & Rodney Williams Memorial Foundation/Conjoint Grant.

2014

  • Evaluating Cochlear Implant after Labyrinthectomy -a human and animal study; Mukherjee P, Brown D; Garnett Passe & Rodney Williams Memorial Foundation/Conjoint Grant.

2013

  • How endolymphatic hydrops affects vestibular function; Curthoys I, Brown D; Garnett Passe & Rodney Williams Memorial Foundation/Project Grants.
  • Effects of Increased Endolymph Volume on Cochlear and Vestibular Function and Morphology of Inner Ear Tissues; Brown D, Curthoys I; National Health and Medical Research Council (NHMRC)/Project Grants.

2012

  • Talking to cells - biointerface as a key parameter in communication with cells; Chrzanowski W, Brown D, Dehghani F, Hibbs D, Ravarian R, Wassef A, Wong J, Yun Y, Lee J, Jang J, Hwang J, Shin S, Shin U, Lee S, Kim H; DVC International/IPDF Grant.

2009

  • Endolymphatic Hydrops in Ménière's Disease: Effects and Objective Measurement in Humans; Gibson W, Brown D; Australian Society of Otolaryngology Head & Neck Surgery Ltd (ASOHNS)/Grace Kathleen Fanton Bequest.

Selected publications

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Journals

  • Brown, D., Chihara, Y., Curthoys, I., Wang, Y., Bos, M. (2013). Changes in cochlear function during acute endolymphatic hydrops development in guinea pigs. Hearing Research, 296, 96-106. [More Information]
  • Brown, D., Chihara, Y., Wang, Y. (2013). Changes in utricular function during artificial endolymph injections in guinea pigs. Hearing Research, 304, 70-76. [More Information]
  • Chihara, Y., Wang, V., Brown, D. (2013). Evidence for the utricular origin of the vestibular short-latency-evoked potential (VsEP) to bone-conducted vibration in guinea pig. Experimental Brain Research, 229(2), 157-170. [More Information]
  • Buljan, V., Holsinger, D., Brown, D., Bohorquez-Florez, J., Hambly, B., Delikatny, E., Ivanova, E., Banati, R. (2013). Spinodal decomposition and the emergence of dissipative transient periodic spatio-temporal patterns in acentrosomal microtubule multitudes of different morphology. Chaos, 23(2), 1-16. [More Information]
  • Chihara, Y., Wong, C., Curthoys, I., Brown, D. (2013). The effect of systemic administration of desmopressin on cochlear function in guinea pigs. Acta Oto-Laryngologica, 133(7), 676-684. [More Information]
  • Brown, D., Gibson, W. (2011). On the differential diagnosis of Meniere's disease using low-frequency acoustic biasing of the 2f1-f2 DPOAE. Hearing Research, 282(1-2), 119-127. [More Information]
  • Brown, D., Patuzzi, R. (2010). Evidence that the compound action potential (CAP) from the auditory nerve is a stationary potential generated across dura mater. Hearing Research, 267(1-2), 12-26. [More Information]
  • Salt, A., Brown, D., Hartsock, J., Plontke, S. (2009). Displacements of the organ of Corti by gel injections into the cochlear apex. Hearing Research, 250, 63-75. [More Information]
  • Brown, D., Hartsock, J., Gill, R., Fitzgerald, H., Salt, A. (2009). Estimating the operating point of the cochlear transducer using low-frequency biased distortion products. Journal of the Acoustical Society of America, 125(4), 2129-2145. [More Information]
  • Patuzzi, R., Brown, D., McMahon, C., Halliday, A. (2004). Determinants of the spectrum of the neural electrical activity at the round window: transmitter release and neural depolarisation. Hearing Research, 190(1-2), 87-108.
  • Brown, D., McMahon, C., Patuzzi, R. (2004). K+ currents produce P1 in the RW CAP: evidence from DC current bias, K+ channel blockade and recordings from cochlea and brainstem. Hearing Research, 190(1-2), 60-74.
  • McMahon, C., Brown, D., Patuzzi, R. (2004). Transient focal cooling at the round window and cochlear nucleus shows round window CAP originates from cochlear neurones alone. Hearing Research, 190(1-2), 75-86.

2013

  • Brown, D., Chihara, Y., Curthoys, I., Wang, Y., Bos, M. (2013). Changes in cochlear function during acute endolymphatic hydrops development in guinea pigs. Hearing Research, 296, 96-106. [More Information]
  • Brown, D., Chihara, Y., Wang, Y. (2013). Changes in utricular function during artificial endolymph injections in guinea pigs. Hearing Research, 304, 70-76. [More Information]
  • Chihara, Y., Wang, V., Brown, D. (2013). Evidence for the utricular origin of the vestibular short-latency-evoked potential (VsEP) to bone-conducted vibration in guinea pig. Experimental Brain Research, 229(2), 157-170. [More Information]
  • Buljan, V., Holsinger, D., Brown, D., Bohorquez-Florez, J., Hambly, B., Delikatny, E., Ivanova, E., Banati, R. (2013). Spinodal decomposition and the emergence of dissipative transient periodic spatio-temporal patterns in acentrosomal microtubule multitudes of different morphology. Chaos, 23(2), 1-16. [More Information]
  • Chihara, Y., Wong, C., Curthoys, I., Brown, D. (2013). The effect of systemic administration of desmopressin on cochlear function in guinea pigs. Acta Oto-Laryngologica, 133(7), 676-684. [More Information]

2011

  • Brown, D., Gibson, W. (2011). On the differential diagnosis of Meniere's disease using low-frequency acoustic biasing of the 2f1-f2 DPOAE. Hearing Research, 282(1-2), 119-127. [More Information]

2010

  • Brown, D., Patuzzi, R. (2010). Evidence that the compound action potential (CAP) from the auditory nerve is a stationary potential generated across dura mater. Hearing Research, 267(1-2), 12-26. [More Information]

2009

  • Salt, A., Brown, D., Hartsock, J., Plontke, S. (2009). Displacements of the organ of Corti by gel injections into the cochlear apex. Hearing Research, 250, 63-75. [More Information]
  • Brown, D., Hartsock, J., Gill, R., Fitzgerald, H., Salt, A. (2009). Estimating the operating point of the cochlear transducer using low-frequency biased distortion products. Journal of the Acoustical Society of America, 125(4), 2129-2145. [More Information]

2004

  • Patuzzi, R., Brown, D., McMahon, C., Halliday, A. (2004). Determinants of the spectrum of the neural electrical activity at the round window: transmitter release and neural depolarisation. Hearing Research, 190(1-2), 87-108.
  • Brown, D., McMahon, C., Patuzzi, R. (2004). K+ currents produce P1 in the RW CAP: evidence from DC current bias, K+ channel blockade and recordings from cochlea and brainstem. Hearing Research, 190(1-2), 60-74.
  • McMahon, C., Brown, D., Patuzzi, R. (2004). Transient focal cooling at the round window and cochlear nucleus shows round window CAP originates from cochlear neurones alone. Hearing Research, 190(1-2), 75-86.

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