Professor Hong Zhou

Senior Principal Research Fellow
Medicine, Concord Clinical School
ANZAC Research Institute

Telephone 02 97679164
Fax 02 97679101

Curriculum vitae Curriculum vitae

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Biographical details

Professor Hong Zhou received her Ph.D from the University of Melbourne. She has extensive skills and experience in bone cell and molecular biology and in the use and analysis of animal models of normal and abnormal bone metabolism, skeletal development, bone and cartilage biology, autoimmune arthritis, surgically induced osteoarthritis, fracture healing and cancer, including genetically modified animal models. Since 2004, she worked continuously and successfully on questions of glucocorticoid and other steroids action in bone, with research output in high-impact journals such as JCI, PNAS, JBC, Arthritis & Rheum, JBMR and Development. She has been the laboratory head since 2008 and has guided 8 PhD studentsto successfullycompleting their studies.

Research interests

Glucocorticoid action on bone and joints, bone regulated systemic metabolism, osteoarthritis.

Current projects

Effects of Exogenous Glucocorticoids on Bone, Fat and Energy Metabolism

S Gasparini, H Henneicke, C Jørgensen, M Swarbrick, H Bräuner-Osborne, H Zhou, MJ Seibel

Interaction of Exogenous Glucocorticoids and Sex Steroids in Metabolic Dysfunction

S Gasparini, H Henneicke,S Kim, D Handelsman,H Zhou, MJ Seibel

Endogenous Glucocorticoids and Ageing

H Henneicke, S Kim, M Swarbrick, P Lee, M Cooper, MJ Seibel, H Zhou

Endogenous Glucocorticoids and Diet-induced Bone, Fat and Metabolic Dysregulation

S Kim, H Henneicke, M Swarbrick, MJ Seibel, H Zhou

Endogenous Glucocorticoids in Immune Arthritis

J Tu, M Cooper, C Little, F Buttgereit, MJ Seibel, H Zhou

Preventing the Spread of Malignant Tumours to Bone

Y Zheng, C Fong-Yee, H Zhou, MJ Seibel

The role of the Vitamin D receptor in malignant bone disease

Y Zheng, K Horas, C Fong-Yee, H Zhou, MJ Seibel

International links

China

(The First Hospital Affiliated to Nanjing Medical University) collabrate with Professor Guoxian Ding to investigate the effects of glucocorticoid on body fat accumulation via suppressing the browning of white adipose tissue

Denmark

(Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen) NHMRC project grant on role of osteocalcin in fuel metabolism

Germany

(Humboldt University Berlin,) collaborate with Prof. Frank Buttgereit-Role of glucocorticoids in autoimmune arthritis

Germany

(Institute of General Zoology and Endocrinology University of Ulm, Ulm, ) the role of glucocorticoid in autoimmune arthritis using glucocorticoid receptor conditional knock out mice

United Kingdom

(University of Birmingham) Collaborate with Prof Paul Stewart and Dr Mark Cooper - Role of 11ß-HSD1 in inflammatory arthritis

United States

(University of Rochester, NY.) Co-investigator Prof. Di Chen-HNMRC Project Grant on How Osteoblasts Control Mesenchymal Progenitors.

Selected grants

2014

  • EVOS FL Auto cell imaging system; Nicholson G, Clark G, Zhou H, Jessup W, Le Couteur D, McMahon A, McLachlan A, Allan C, Handelsman D, Hart D, Walters K, Kritharides L, Kockx M, Kennerson M, Cooper M, Seibel M, Verma N, Silveira P, Fromm P, Simanainen U, Cogger V, Zheng Y; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • The Role of Osteoblastic Glucocorticoid in Ageing; Zhou H; DVC Research/Bridging Support Grant.
  • IVIS Lumina II in vivo Imaging System; Seibel M, Handelsman D, Le Couteur D, Hart D, Nicholson G, Freedman B, Kritharides L, Jessup W, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, McMahon A, Simanainen U, Kockx M, Speranza T, Zheng Y; DVC Research/Equipment Grant.
  • Novel Cytoplasmic Functions of the Vitamin D Receptor in Bone Metastases; Seibel M, Zheng Y, Croucher P, Zhou H, Guise T, Dunstan C; Cancer Council New South Wales/Research Project Grants.
  • Automacs Pro Seperator; Hart D, Handelsman D, Le Couteur D, Nicholson G, Kritharides L, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, Simanainen U, Zheng Y, Seibel M; DVC Research/Equipment Grant.

2011

  • The role of endogenous glucocorticoids in Inflammatory arthritis; Zhou H, Seibel M; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • MOLECULAR IMAGER CHEMIDoc XRS SYSTEM & MINI P ROTEAN GEL/TRANSBLOT Cell SYSTEM (BIO-RAD. AUSTRALIA; Allan C, Handelsman D, Zhou H, Seibel M, Kennerson M, Nicholson G, Blair I, Le Couteur D, McMahon A, Hart D, Clark G, Simanainen U; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • The role of endogenous glucocorticoids in Autoimmune Arthritis; Zhou H, Cooper M, Seibel M, Stewart P, Buttgereit F, Cooper M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Role of Lamin A/C in Osteoblastogenesis and Age-related Bone Loss; Duque G, Zhou H, Drissi H, Li W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The Role of the Osteoblast in Mediating Glucocorticoid-induced Metabolic Dysfunction; Seibel M, Zhou H, Gundberg C, Dunstan C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The Lunar PIXImus II DEXA Scanner; Zhou H, Seibel M, Handelsman D, Le Couteur D, Nicholson G, Clarke S, Robertson G, van Zandwijk N, Freedman B, Kennerson M, Allan C, Walters K, Cogger V, Blair I, Reid G, Simanainen U; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Osteoblast Control of Mesenchymal Progenitor Cell Differentiation: The Role of Glucocorticoids and Wnt Signalling; Zhou H, Chen D, Seibel M, Chen D, Dunstan C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Stereomicroscope-Imaging Workstation; Allan C, Seibel M, Handelsman D, Le Couteur D, Kennerson M, Robertson G, Walters K, Cogger V, Nicholson G, Zhou H, Blair I, Simanainen U, McMahon A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation; Munroe P, Jones A, Zhou H, Cairney J, Einav I, Swain M, Murphy C, Seibel M, Ringer S, Li Q, Darendeliler M, Wang X, Zhang Y, Hand S, Archer M, Ramzan I, Young P, Traini D, Richardson D, Masters A, Milthorpe B; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2008

  • How Osteoblasts control Mesenchymal Progenitors: A Novel Concept of Interaction between Mature and I; Zhou H; University of Sydney/Bridging Support.

2007

  • Leica CM3050 S cryostat; Seibel M, Blair J, Dunstan C, Handelsman D, Nicholson G, Kennerson M, Lowe H, Witting P, Allan C, Zhou H; University of Sydney/Major Equipment Grant.

2006

  • Glucocorticoid effects on bone: the role of the osteoblast; Seibel M, Zhou H, Dunstan C, Krozowski Z; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Cell culture quarantine and storage facility plus assessories; Dunstan C, Witting P, Myers S, Handelsman D, Seibel M, Nicholson G, Zhou H, Kennerson M, Allan C, Freedman B, Le Couteur D, Muller M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2005

  • Bone resorption in breast cancer metastasis; Blair J, Dunstan C, Seibel M, Zhou H; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Zheng, Y., Seibel, M., Zhou, H. (2011). Methods in Bone Biology: Cancer and Bone. In Gustavo Duque, Ken Watanabe (Eds.), Osteoporosis Research: Animal Models, (pp. 83-91). London: Springer.
  • Dunstan, C., Blair, J., Zhou, H., Seibel, M. (2007). Bone, Mineral, Connective Tissue Metabolism. In Taylor J; Triggle D (vol ed Michael Williams) (Eds.), Comprehensive Medicinal Chemistry II, (pp. 495-520). Oxford, United Kingdom: Elsevier.

Journals

  • Zhou, H., Seibel, M. (2017). Bone: Osteoblasts and global energy metabolism - beyond osteocalcin. Nature Reviews Rheumatology, 13(5), 261-262. [More Information]
  • Gasparini, S., Weber, M., Henneicke, H., Kim, S., Zhou, H., Seibel, M. (2016). Continuous corticosterone delivery via the drinking water or pellet implantation: A comparative study in mice. Steroids, 116, 76-82. [More Information]
  • Cooper, M., Seibel, M., Zhou, H. (2016). Glucocorticoids, bone and energy metabolism. Bone, 82, 64-68. [More Information]
  • Tu, J., Zhang, Y., Kim, S., Wiebe, E., Spies, C., Buttgereit, F., Cooper, M., Seibel, M., Zhou, H. (2016). Transgenic Disruption of Glucocorticoid Signaling in Osteoblasts Attenuates Joint Inflammation in Collagen Antibody-Induced Arthritis. The American Journal of Pathology, 186(5), 1293-1301. [More Information]
  • Henneicke, H., Gasparini, S., Zhou, H., Hofbauer, L., Seibel, M. (2016). Zellulare Mechanismen der Gluko-kortikoid-induzierten Osteoporose und therapeutische Ansatzpunkte. Osteologie: interdisziplinaere Zeitschrift fuer Knochen und Gelenke, 25(4), 247-252.
  • Horas, K., Zheng, Y., Zhou, H., Seibel, M. (2015). Animal Models for Breast Cancer Metastasis to Bone: Opportunities and Limitations. Cancer Investigation, 33(9), 459-468. [More Information]
  • Zheng, L., Cao, H., Chen, S., Tang, T., Fu, W., Huang, L., Chow, D., Wang, Y., Griffith, J., He, W., Zhou, H., et al (2015). Blockage of Src by Specific siRNA as a Novel Therapeutic Strategy to Prevent Destructive Repair in Steroid-Associated Osteonecrosis in Rabbits. Journal of Bone and Mineral Research, 30(11), 2044-2057. [More Information]
  • Wang, T., Li, J., Jin, Z., Wu, F., Li, Y., Wang, X., Zhou, H., Zhou, Q. (2015). Dynamic Frequency of Blood CD4+CD25+ Regulatory T Cells in Rats with Collagen-induced Arthritis. Korean Journal of Physiology and Pharmacology, 19(2), 83-88. [More Information]
  • Kong, X., Yu, J., Bi, J., Qi, H., Di, W., Wu, L., Wang, L., Zha, J., Lv, S., Zhang, F., Zhou, H., et al (2015). Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue. Diabetes, 64(2), 393-404. [More Information]
  • Bermeo, S., Vidal, C., Zhou, H., Duque, G. (2015). Lamin A/C Acts as an Essential Factor in Mesenchymal Stem Cell Differentiation through the Regulation of the Dynamics of the Wnt/B-Catenin Pathway. Journal Of Cellular Biochemistry, 116(10), 2344-2353. [More Information]
  • Ji, Z., Dang, X., Wang, K., Zhou, H. (2015). Micro-CT analysis on subchondral-bone microstructure of tibia in a mouse model of osteoarthritis. Journal of Xi'an Jiaotong University (Medical Sciences), 36(5), 623-627 and 654. [More Information]
  • Cui, X., Li, S., Li, T., Peng, H., Jin, T., Zhang, S., Liu, C., Yang, L., Zhou, H., Zheng, Y., et al (2015). Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma. Oncotarget, 7(2), 1777-1795. [More Information]
  • Spies, C., Wiebe, E., Tu, J., Li, A., Gaber, T., Huscher, D., Seibel, M., Zhou, H., Buttgereit, F. (2014). Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling. BMC Musculoskeletal Disorders, 15, 1-11. [More Information]
  • Gao, Y., Walters, K., Desai, R., Zhou, H., Handelsman, D., Simanainen, U. (2014). Androgen receptor inactivation resulted in acceleration in pubertal mammary gland growth, upregulation of ERα expression, and Wnt/β-catenin signaling in female mice. Endocrinology, 155(12), 4951-4963. [More Information]
  • Zheng, Y., Chow, S., Boernert, K., Basel, D., Mikuscheva, A., Kim, S., Fong�?Yee, C., Trivedi, T., Buttgereit, F., Sutherland, R., Dunstan, C., Zhou, H., Seibel, M. (2014). Direct Crosstalk Between Cancer and Osteoblast Lineage Cells Fuels Metastatic Growth in Bone via Auto-Amplification of IL-6 and RANKL Signaling Pathways. Journal of Bone and Mineral Research, 29(9), 1938-1949. [More Information]
  • Tu, J., Henneicke, H., Zhang, Y., Stoner, S., Cheng, T., Schindeler, A., Chen, D., Tuckermann, J., Cooper, M., Seibel, M., Zhou, H. (2014). Disruption of glucocorticoid signaling in chondrocytes delays metaphyseal fracture healing but does not affect normal cartilage and bone development. Bone, 69, 12-22. [More Information]
  • Zhao, B., Choi, J., Jaehne, M., Gao, Y., Desai, R., Tuckermann, J., Zhou, H., Handelsman, D., Simanainen, U. (2014). Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate. The Prostate, 74(10), 1068-1078. [More Information]
  • Henneicke, H., Gasparini, S., Speranza, T., Zhou, H., Seibel, M. (2014). Glucocorticoids and bone: local effects and systemic implications. Trends in Endocrinology and Metabolism, 25(4), 197-211. [More Information]
  • Zheng, Y., Basel, D., Chow, S., Fong-Yee, C., Kim, S., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M. (2014). Targeting IL-6 and RANKL signaling inhibits prostate cancer growth in bone. Clinical and Experimental Metastasis, 31(8), 921-933. [More Information]
  • Hardy, R., Hulso, C., Liu, Y., Gasparini, S., Fong-Yee, C., Tu, J., Stoner, S., Stewart, P., Raza, K., Cooper, M., Seibel, M., Zhou, H. (2013). Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation. Arthritis Research & Therapy, 15(1), 1-14. [More Information]
  • Li, A., Hardy, R., Stoner, S., Tuckermann, J., Seibel, M., Zhou, H. (2013). Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure. PloS One, 8(5), 1-11. [More Information]
  • Seibel, M., Cooper, M., Zhou, H. (2013). Glucocorticoid-induced osteoporosis: Mechanisms, management, and future perspectives. The Lancet Diabetes & Endocrinology, 1(1), 59-70. [More Information]
  • Zheng, Y., Zhou, H., Dunstan, C., Sutherland, R., Seibel, M. (2013). The role of the bone microenvironment in skeletal metastasis. Journal of Bone Oncology, 2(1), 47-57. [More Information]
  • Georgiou, K., King, T., Scherer, M., Zhou, H., Foster, B., Xian, C. (2012). Attenuated Wnt/beta-catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats. Bone, 50(6), 1223-1233. [More Information]
  • Speranza, T., Henneicke, H., Gasparini, S., Blankenstein, K., Heinevetter, U., Cogger, V., Svistounov, D., Zhang, Y., Cooney, G., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M., et al (2012). Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. Journal of Clinical Investigation, 122(11), 4172-4189. [More Information]
  • Cooper, M., Zhou, H., Seibel, M. (2012). Selective glucocorticoid receptor agonists: Glucocorticoid therapy with no regrets? Journal of Bone and Mineral Research, 27(11), 2238-2241. [More Information]
  • Henneicke, H., Herrmann, M., Kalak, R., Speranza, T., Bertollo, N., Day, R., Huscher, D., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2011). Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism. Bone, 49(4), 733-742. [More Information]
  • Buttgereit, F., Burmester, G., Straub, R., Seibel, M., Zhou, H. (2011). Exogenous and endogenous glucocorticoids in rheumatic diseases. Arthritis & Rheumatology, 63(1), 1-9. [More Information]
  • Allan, C., Kalak, R., Dunstan, C., McTavish, K., Zhou, H., Handelsman, D., Seibel, M. (2010). Follicle-stimulating hormone increases bone mass in female mice. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 107(52), 22629-22634. [More Information]
  • Liu, P., Kalak, R., Lue, Y., Jia, Y., Erkkila, K., Zhou, H., Seibel, M., Wang, C., Swerdloff, R., Dunstan, C. (2010). Genetic and Hormonal Control of Bone Volume, Architecture, and Remodeling in XXY Mice. Journal of Bone and Mineral Research, 25(10), 2148-2154. [More Information]
  • Simanainen, U., Lampinen, A., Henneicke, H., Speranza, T., Heinevetter, U., Harwood, D., McNamara, K., Herrmann, M., Seibel, M., Handelsman, D., Zhou, H. (2010). Long-Term Corticosterone Treatment Induced Lobe-Specific Pathology in Mouse Prostate. The Prostate, 71(3), 289-297. [More Information]
  • Weber, A., Li, G., Kalak, R., Street, J., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2010). Osteoblast-targeted disruption of glucocorticoid signalling does not delay intramembranous bone healing. Steroids, 75(3), 282-286. [More Information]
  • Ooi, L., Zheng, Y., Zhou, H., Trivedi, T., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis. Bone, 47(4), 795-803. [More Information]
  • Ooi, L., Zhou, H., Kalak, R., Zheng, Y., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Research, 70(5), 1835-1844. [More Information]
  • Zheng, Y., Zhou, H., Ooi, L., Snir, A., Dunstan, C., Seibel, M. (2010). Vitamin D deficiency promotes prostate cancer growth in bone. The Prostate, , 1-10. [More Information]
  • Mak, W., Shao, X., Dunstan, C., Seibel, M., Zhou, H. (2009). Biphasic Glucocorticoid-Dependent Regulation of Wnt Expression and Its Inhibitors in Mature Osteoblastic Cells. Calcified Tissue International, 85(6), 538-545. [More Information]
  • Kalak, R., Zhou, H., Street, J., Day, R., Modzelewski, J., Spies, C., Liu, P., Li, G., Dunstan, C., Seibel, M. (2009). Endogenous glucocorticoid signaling in osteoblasts is necessary to maintain normal bone structure in mice. Bone, 45(1), 61-67. [More Information]
  • Zhou, H., Mak, W., Kalak, R., Street, J., Fong-Yee, C., Zheng, Y., Dunstan, C., Seibel, M. (2009). Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice. Development, 136(3), 427-436. [More Information]
  • Herrmann, M., Henneicke, H., Street, J., Modzelewski, J., Kalak, R., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M. (2009). The challenge of continuous exogenous glucocorticoid administration in mice. Steroids, 74(2), 245-249. [More Information]
  • Buttgereit, F., Zhou, H., Kalak, R., Gaber, T., Spies, C., Huscher, D., Straub, R., Modzelewski, J., Dunstan, C., Seibel, M. (2009). Transgenic Disruption of Glucocorticoid Signaling in Mature Osteoblasts and Osteocytes Attenuates K/BxN Mouse Serum-Induced Arthritis In Vivo. Arthritis Care and Research, 60(7), 1998-2007. [More Information]
  • Buttgereit, F., Zhou, H., Seibel, M. (2008). Arthritis and endogenous glucocorticoids: the emerging role of the 11beta-HSD enzymes. Annals of the Rheumatic Diseases, 67(9), 1201-1203. [More Information]
  • Ramaswamy, Y., Wu, C., Zhou, H., Zreiqat, H. (2008). Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomaterialia, 4(5), 1487-1497. [More Information]
  • Zheng, Y., Zhou, H., Fong-Yee, C., Modzelewski, J., Seibel, M., Dunstan, C. (2008). Bone Resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis. Clinical and Experimental Metastasis, 25(5), 559-567. [More Information]
  • Zhou, H., Mak, W., Zheng, Y., Dunstan, C., Seibel, M. (2008). Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through WNT signaling. Journal of Biological Chemistry, 283(4), 1936-1945. [More Information]
  • Kartsogiannis, V., Sims, N., Quinn, J., Ly, C., Cipetic, M., Poulton, I., Walker, E., Saleh, H., Zhou, H., et al (2008). Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo. Journal of Biological Chemistry, 283(45), 30850-30860. [More Information]
  • Zheng, Y., Zhou, H., Modzelewski, J., Kalak, R., Blair, J., Seibel, M., Dunstan, C. (2007). Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone. Cancer Research, 67(19), 9542-9548. [More Information]
  • Blair, J., Zhou, H., Seibel, M., Dunstan, C. (2006). Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis. Nature Clinical Practice Oncology, 3(1), 41-49. [More Information]
  • Seibel, M., Dunstan, C., Zhou, H., Allan, C., Handelsman, D. (2006). Sex steroids, not FSH, influence bone mass. Cell, 127(6), 1079-1079. [More Information]
  • Dunstan, C., Zhou, H., Seibel, M. (2004). Fibroblast Growth Factor 23: A Phospatonin Regulating Phosphate Homeostasis? Endocrinology, 145(7), 3084-3086. [More Information]

Reference Works

  • Zhou, H., Chen, D., Dunstan, C., Seibel, M. (2009). Bone Metabolism. In Stefan Offermanns, Walter Rosenthal (Eds.), Bone Metabolism. (Vol. 1, pp. 276-282). USA: Springer.

2017

  • Zhou, H., Seibel, M. (2017). Bone: Osteoblasts and global energy metabolism - beyond osteocalcin. Nature Reviews Rheumatology, 13(5), 261-262. [More Information]

2016

  • Gasparini, S., Weber, M., Henneicke, H., Kim, S., Zhou, H., Seibel, M. (2016). Continuous corticosterone delivery via the drinking water or pellet implantation: A comparative study in mice. Steroids, 116, 76-82. [More Information]
  • Cooper, M., Seibel, M., Zhou, H. (2016). Glucocorticoids, bone and energy metabolism. Bone, 82, 64-68. [More Information]
  • Tu, J., Zhang, Y., Kim, S., Wiebe, E., Spies, C., Buttgereit, F., Cooper, M., Seibel, M., Zhou, H. (2016). Transgenic Disruption of Glucocorticoid Signaling in Osteoblasts Attenuates Joint Inflammation in Collagen Antibody-Induced Arthritis. The American Journal of Pathology, 186(5), 1293-1301. [More Information]
  • Henneicke, H., Gasparini, S., Zhou, H., Hofbauer, L., Seibel, M. (2016). Zellulare Mechanismen der Gluko-kortikoid-induzierten Osteoporose und therapeutische Ansatzpunkte. Osteologie: interdisziplinaere Zeitschrift fuer Knochen und Gelenke, 25(4), 247-252.

2015

  • Horas, K., Zheng, Y., Zhou, H., Seibel, M. (2015). Animal Models for Breast Cancer Metastasis to Bone: Opportunities and Limitations. Cancer Investigation, 33(9), 459-468. [More Information]
  • Zheng, L., Cao, H., Chen, S., Tang, T., Fu, W., Huang, L., Chow, D., Wang, Y., Griffith, J., He, W., Zhou, H., et al (2015). Blockage of Src by Specific siRNA as a Novel Therapeutic Strategy to Prevent Destructive Repair in Steroid-Associated Osteonecrosis in Rabbits. Journal of Bone and Mineral Research, 30(11), 2044-2057. [More Information]
  • Wang, T., Li, J., Jin, Z., Wu, F., Li, Y., Wang, X., Zhou, H., Zhou, Q. (2015). Dynamic Frequency of Blood CD4+CD25+ Regulatory T Cells in Rats with Collagen-induced Arthritis. Korean Journal of Physiology and Pharmacology, 19(2), 83-88. [More Information]
  • Kong, X., Yu, J., Bi, J., Qi, H., Di, W., Wu, L., Wang, L., Zha, J., Lv, S., Zhang, F., Zhou, H., et al (2015). Glucocorticoids transcriptionally regulate miR-27b expression promoting body fat accumulation via suppressing the browning of white adipose tissue. Diabetes, 64(2), 393-404. [More Information]
  • Bermeo, S., Vidal, C., Zhou, H., Duque, G. (2015). Lamin A/C Acts as an Essential Factor in Mesenchymal Stem Cell Differentiation through the Regulation of the Dynamics of the Wnt/B-Catenin Pathway. Journal Of Cellular Biochemistry, 116(10), 2344-2353. [More Information]
  • Ji, Z., Dang, X., Wang, K., Zhou, H. (2015). Micro-CT analysis on subchondral-bone microstructure of tibia in a mouse model of osteoarthritis. Journal of Xi'an Jiaotong University (Medical Sciences), 36(5), 623-627 and 654. [More Information]
  • Cui, X., Li, S., Li, T., Peng, H., Jin, T., Zhang, S., Liu, C., Yang, L., Zhou, H., Zheng, Y., et al (2015). Targeting oncogenic PLCE1 by miR-145 impairs tumor proliferation and metastasis of esophageal squamous cell carcinoma. Oncotarget, 7(2), 1777-1795. [More Information]

2014

  • Spies, C., Wiebe, E., Tu, J., Li, A., Gaber, T., Huscher, D., Seibel, M., Zhou, H., Buttgereit, F. (2014). Acute murine antigen-induced arthritis is not affected by disruption of osteoblastic glucocorticoid signalling. BMC Musculoskeletal Disorders, 15, 1-11. [More Information]
  • Gao, Y., Walters, K., Desai, R., Zhou, H., Handelsman, D., Simanainen, U. (2014). Androgen receptor inactivation resulted in acceleration in pubertal mammary gland growth, upregulation of ERα expression, and Wnt/β-catenin signaling in female mice. Endocrinology, 155(12), 4951-4963. [More Information]
  • Zheng, Y., Chow, S., Boernert, K., Basel, D., Mikuscheva, A., Kim, S., Fong�?Yee, C., Trivedi, T., Buttgereit, F., Sutherland, R., Dunstan, C., Zhou, H., Seibel, M. (2014). Direct Crosstalk Between Cancer and Osteoblast Lineage Cells Fuels Metastatic Growth in Bone via Auto-Amplification of IL-6 and RANKL Signaling Pathways. Journal of Bone and Mineral Research, 29(9), 1938-1949. [More Information]
  • Tu, J., Henneicke, H., Zhang, Y., Stoner, S., Cheng, T., Schindeler, A., Chen, D., Tuckermann, J., Cooper, M., Seibel, M., Zhou, H. (2014). Disruption of glucocorticoid signaling in chondrocytes delays metaphyseal fracture healing but does not affect normal cartilage and bone development. Bone, 69, 12-22. [More Information]
  • Zhao, B., Choi, J., Jaehne, M., Gao, Y., Desai, R., Tuckermann, J., Zhou, H., Handelsman, D., Simanainen, U. (2014). Glucocorticoid receptor in prostate epithelia is not required for corticosteroid-induced epithelial hyperproliferation in the mouse prostate. The Prostate, 74(10), 1068-1078. [More Information]
  • Henneicke, H., Gasparini, S., Speranza, T., Zhou, H., Seibel, M. (2014). Glucocorticoids and bone: local effects and systemic implications. Trends in Endocrinology and Metabolism, 25(4), 197-211. [More Information]
  • Zheng, Y., Basel, D., Chow, S., Fong-Yee, C., Kim, S., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M. (2014). Targeting IL-6 and RANKL signaling inhibits prostate cancer growth in bone. Clinical and Experimental Metastasis, 31(8), 921-933. [More Information]

2013

  • Hardy, R., Hulso, C., Liu, Y., Gasparini, S., Fong-Yee, C., Tu, J., Stoner, S., Stewart, P., Raza, K., Cooper, M., Seibel, M., Zhou, H. (2013). Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation. Arthritis Research & Therapy, 15(1), 1-14. [More Information]
  • Li, A., Hardy, R., Stoner, S., Tuckermann, J., Seibel, M., Zhou, H. (2013). Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure. PloS One, 8(5), 1-11. [More Information]
  • Seibel, M., Cooper, M., Zhou, H. (2013). Glucocorticoid-induced osteoporosis: Mechanisms, management, and future perspectives. The Lancet Diabetes & Endocrinology, 1(1), 59-70. [More Information]
  • Zheng, Y., Zhou, H., Dunstan, C., Sutherland, R., Seibel, M. (2013). The role of the bone microenvironment in skeletal metastasis. Journal of Bone Oncology, 2(1), 47-57. [More Information]

2012

  • Georgiou, K., King, T., Scherer, M., Zhou, H., Foster, B., Xian, C. (2012). Attenuated Wnt/beta-catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats. Bone, 50(6), 1223-1233. [More Information]
  • Speranza, T., Henneicke, H., Gasparini, S., Blankenstein, K., Heinevetter, U., Cogger, V., Svistounov, D., Zhang, Y., Cooney, G., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M., et al (2012). Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. Journal of Clinical Investigation, 122(11), 4172-4189. [More Information]
  • Cooper, M., Zhou, H., Seibel, M. (2012). Selective glucocorticoid receptor agonists: Glucocorticoid therapy with no regrets? Journal of Bone and Mineral Research, 27(11), 2238-2241. [More Information]

2011

  • Henneicke, H., Herrmann, M., Kalak, R., Speranza, T., Bertollo, N., Day, R., Huscher, D., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2011). Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism. Bone, 49(4), 733-742. [More Information]
  • Buttgereit, F., Burmester, G., Straub, R., Seibel, M., Zhou, H. (2011). Exogenous and endogenous glucocorticoids in rheumatic diseases. Arthritis & Rheumatology, 63(1), 1-9. [More Information]
  • Zheng, Y., Seibel, M., Zhou, H. (2011). Methods in Bone Biology: Cancer and Bone. In Gustavo Duque, Ken Watanabe (Eds.), Osteoporosis Research: Animal Models, (pp. 83-91). London: Springer.

2010

  • Allan, C., Kalak, R., Dunstan, C., McTavish, K., Zhou, H., Handelsman, D., Seibel, M. (2010). Follicle-stimulating hormone increases bone mass in female mice. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 107(52), 22629-22634. [More Information]
  • Liu, P., Kalak, R., Lue, Y., Jia, Y., Erkkila, K., Zhou, H., Seibel, M., Wang, C., Swerdloff, R., Dunstan, C. (2010). Genetic and Hormonal Control of Bone Volume, Architecture, and Remodeling in XXY Mice. Journal of Bone and Mineral Research, 25(10), 2148-2154. [More Information]
  • Simanainen, U., Lampinen, A., Henneicke, H., Speranza, T., Heinevetter, U., Harwood, D., McNamara, K., Herrmann, M., Seibel, M., Handelsman, D., Zhou, H. (2010). Long-Term Corticosterone Treatment Induced Lobe-Specific Pathology in Mouse Prostate. The Prostate, 71(3), 289-297. [More Information]
  • Weber, A., Li, G., Kalak, R., Street, J., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2010). Osteoblast-targeted disruption of glucocorticoid signalling does not delay intramembranous bone healing. Steroids, 75(3), 282-286. [More Information]
  • Ooi, L., Zheng, Y., Zhou, H., Trivedi, T., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis. Bone, 47(4), 795-803. [More Information]
  • Ooi, L., Zhou, H., Kalak, R., Zheng, Y., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Research, 70(5), 1835-1844. [More Information]
  • Zheng, Y., Zhou, H., Ooi, L., Snir, A., Dunstan, C., Seibel, M. (2010). Vitamin D deficiency promotes prostate cancer growth in bone. The Prostate, , 1-10. [More Information]

2009

  • Mak, W., Shao, X., Dunstan, C., Seibel, M., Zhou, H. (2009). Biphasic Glucocorticoid-Dependent Regulation of Wnt Expression and Its Inhibitors in Mature Osteoblastic Cells. Calcified Tissue International, 85(6), 538-545. [More Information]
  • Zhou, H., Chen, D., Dunstan, C., Seibel, M. (2009). Bone Metabolism. In Stefan Offermanns, Walter Rosenthal (Eds.), Bone Metabolism. (Vol. 1, pp. 276-282). USA: Springer.
  • Kalak, R., Zhou, H., Street, J., Day, R., Modzelewski, J., Spies, C., Liu, P., Li, G., Dunstan, C., Seibel, M. (2009). Endogenous glucocorticoid signaling in osteoblasts is necessary to maintain normal bone structure in mice. Bone, 45(1), 61-67. [More Information]
  • Zhou, H., Mak, W., Kalak, R., Street, J., Fong-Yee, C., Zheng, Y., Dunstan, C., Seibel, M. (2009). Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice. Development, 136(3), 427-436. [More Information]
  • Herrmann, M., Henneicke, H., Street, J., Modzelewski, J., Kalak, R., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M. (2009). The challenge of continuous exogenous glucocorticoid administration in mice. Steroids, 74(2), 245-249. [More Information]
  • Buttgereit, F., Zhou, H., Kalak, R., Gaber, T., Spies, C., Huscher, D., Straub, R., Modzelewski, J., Dunstan, C., Seibel, M. (2009). Transgenic Disruption of Glucocorticoid Signaling in Mature Osteoblasts and Osteocytes Attenuates K/BxN Mouse Serum-Induced Arthritis In Vivo. Arthritis Care and Research, 60(7), 1998-2007. [More Information]

2008

  • Buttgereit, F., Zhou, H., Seibel, M. (2008). Arthritis and endogenous glucocorticoids: the emerging role of the 11beta-HSD enzymes. Annals of the Rheumatic Diseases, 67(9), 1201-1203. [More Information]
  • Ramaswamy, Y., Wu, C., Zhou, H., Zreiqat, H. (2008). Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomaterialia, 4(5), 1487-1497. [More Information]
  • Zheng, Y., Zhou, H., Fong-Yee, C., Modzelewski, J., Seibel, M., Dunstan, C. (2008). Bone Resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis. Clinical and Experimental Metastasis, 25(5), 559-567. [More Information]
  • Zhou, H., Mak, W., Zheng, Y., Dunstan, C., Seibel, M. (2008). Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through WNT signaling. Journal of Biological Chemistry, 283(4), 1936-1945. [More Information]
  • Kartsogiannis, V., Sims, N., Quinn, J., Ly, C., Cipetic, M., Poulton, I., Walker, E., Saleh, H., Zhou, H., et al (2008). Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo. Journal of Biological Chemistry, 283(45), 30850-30860. [More Information]

2007

  • Zheng, Y., Zhou, H., Modzelewski, J., Kalak, R., Blair, J., Seibel, M., Dunstan, C. (2007). Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone. Cancer Research, 67(19), 9542-9548. [More Information]
  • Dunstan, C., Blair, J., Zhou, H., Seibel, M. (2007). Bone, Mineral, Connective Tissue Metabolism. In Taylor J; Triggle D (vol ed Michael Williams) (Eds.), Comprehensive Medicinal Chemistry II, (pp. 495-520). Oxford, United Kingdom: Elsevier.

2006

  • Blair, J., Zhou, H., Seibel, M., Dunstan, C. (2006). Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis. Nature Clinical Practice Oncology, 3(1), 41-49. [More Information]
  • Seibel, M., Dunstan, C., Zhou, H., Allan, C., Handelsman, D. (2006). Sex steroids, not FSH, influence bone mass. Cell, 127(6), 1079-1079. [More Information]

2004

  • Dunstan, C., Zhou, H., Seibel, M. (2004). Fibroblast Growth Factor 23: A Phospatonin Regulating Phosphate Homeostasis? Endocrinology, 145(7), 3084-3086. [More Information]

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