Associate Professor Hong Zhou

Principal Research Fellow
Medicine, Concord Clinical School
ANZAC Research Institute

Telephone 02 97679164
Fax 02 97679101

Curriculum vitae Curriculum vitae

Map

Research interests

I have a long-standing track record in basic research into bone biology. I have extensive experience in bone cell and molecular biology and in the use and analysis of animal models of bone disease, including transgenic, fracture healing and cancer models. My major scientific interests include effects of glucocorticoids on bone. I have made significant discoveries how glucocorticoids, through the osteoblast, regulate mesenchymal stem cell commitment and skeletal development in mice; fund that glucocorticoid signalling in osteoblasts up-regulates autoimmune arthritis in vivo and disrupting GC-signaling in osteoblasts protects mice against both the bone-wasting and diabetogenic effects of pharmacological GC doses.

International links

Denmark

(Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen) NHMRC project grant on role of osteocalcin in fuel metabolism

Germany

(Humboldt University Berlin,) collaborate with Prof. Frank Buttgereit-Role of glucocorticoids in autoimmune arthritis

Germany

(Institute of General Zoology and Endocrinology University of Ulm, Ulm, ) the role of glucocorticoid in autoimmune arthritis using glucocorticoid receptor conditional knock out mice

United Kingdom

(University of Birmingham) Collaborate with Prof Paul Stewart and Dr Mark Cooper - Role of 11ß-HSD1 in inflammatory arthritis

United States

(University of Rochester, NY.) Co-investigator Prof. Di Chen-HNMRC Project Grant on How Osteoblasts Control Mesenchymal Progenitors.

Selected grants

2014

  • EVOS® FL Auto cell imaging system; Nicholson G, Clark G, Zhou H, Jessup W, Le Couteur D, McMahon A, McLachlan A, Allan C, Handelsman D, Hart D, Walters K, Kritharides L, Kockx M, Kennerson M, Cooper M, Seibel M, Verma N, Silveira P, Fromm P, Simanainen U, Cogger V, Zheng Y; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • The Role of Osteoblastic Glucocorticoid in Ageing; Zhou H; DVC Research/Bridging Support Grant.
  • IVIS Lumina II in vivo Imaging System; Seibel M, Handelsman D, Le Couteur D, Hart D, Nicholson G, Freedman B, Kritharides L, Jessup W, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, McMahon A, Simanainen U, Kockx M, Speranza T, Zheng Y; DVC Research/Equipment Grant.
  • Automacs Pro Seperator; Hart D, Handelsman D, Le Couteur D, Nicholson G, Kritharides L, Zhou H, Clark G, Kennerson M, Allan C, Walters K, Cogger V, Simanainen U, Zheng Y, Seibel M; DVC Research/Equipment Grant.
  • Novel Cytoplasmic Functions of the Vitamin D Receptor in Bone Metastases; Seibel M, Zheng Y, Croucher P, Zhou H, Guise T, Dunstan C; Cancer Council New South Wales/Research Project Grants.

2011

  • The role of endogenous glucocorticoids in Inflammatory arthritis; Zhou H, Seibel M; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • MOLECULAR IMAGER CHEMIDoc XRS SYSTEM & MINI P ROTEAN GEL/TRANSBLOT Cell SYSTEM (BIO-RAD. AUSTRALIA; Allan C, Handelsman D, Zhou H, Seibel M, Kennerson M, Nicholson G, Blair I, Le Couteur D, McMahon A, Hart D, Clark G, Simanainen U; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2010

  • The Lunar PIXImus II DEXA Scanner; Zhou H, Seibel M, Handelsman D, Le Couteur D, Nicholson G, Clarke S, Robertson G, van Zandwijk N, Freedman B, Kennerson M, Allan C, Walters K, Cogger V, Blair I, Reid G, Simanainen U; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Role of Lamin A/C in Osteoblastogenesis and Age-related Bone Loss; Duque G, Zhou H, Drissi H, Li W; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The role of endogenous glucocorticoids in Autoimmune Arthritis; Zhou H, Cooper M, Seibel M, Stewart P, Buttgereit F, Cooper M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The Role of the Osteoblast in Mediating Glucocorticoid-induced Metabolic Dysfunction; Seibel M, Zhou H, Gundberg C, Dunstan C; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Osteoblast Control of Mesenchymal Progenitor Cell Differentiation: The Role of Glucocorticoids and Wnt Signalling; Zhou H, Chen D, Seibel M, Chen D, Dunstan C; National Health and Medical Research Council (NHMRC)/Project Grants.
  • A Multi-Resolution X-ray Microtomography Facility (NanoCT & MicroCT) for Non-Destructive 3D Characterisation; Munroe P, Jones A, Zhou H, Cairney J, Einav I, Swain M, Murphy C, Seibel M, Ringer S, Li Q, Darendeliler M, Wang X, Zhang Y, Hand S, Archer M, Ramzan I, Young P, Traini D, Richardson D, Masters A, Milthorpe B; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Stereomicroscope-Imaging Workstation; Allan C, Seibel M, Handelsman D, Le Couteur D, Kennerson M, Robertson G, Walters K, Cogger V, Nicholson G, Zhou H, Blair I, Simanainen U, McMahon A; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • How Osteoblasts control Mesenchymal Progenitors: A Novel Concept of Interaction between Mature and I; Zhou H; University of Sydney/Bridging Support.

2007

  • Leica CM3050 S cryostat; Seibel M, Blair J, Dunstan C, Handelsman D, Nicholson G, Kennerson M, Lowe H, Witting P, Allan C, Zhou H; University of Sydney/Major Equipment.

2006

  • Cell culture quarantine and storage facility plus assessories; Dunstan C, Witting P, Myers S, Handelsman D, Seibel M, Nicholson G, Zhou H, Kennerson M, Allan C, Freedman B, Le Couteur D, Muller M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Glucocorticoid effects on bone: the role of the osteoblast; Seibel M, Zhou H, Dunstan C, Krozowski Z; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • Bone resorption in breast cancer metastasis; Blair J, Dunstan C, Seibel M, Zhou H; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Book Chapters

  • Zheng, Y., Seibel, M., Zhou, H. (2011). Methods in Bone Biology: Cancer and Bone. In Gustavo Duque, Ken Watanabe (Eds.), Osteoporosis Research: Animal Models, (pp. 83-91). London: Springer.
  • Dunstan, C., Blair, J., Zhou, H., Seibel, M. (2007). Bone, Mineral, Connective Tissue Metabolism. In Taylor J; Triggle D (vol ed Michael Williams) (Eds.), Comprehensive Medicinal Chemistry II, (pp. 495-520). Oxford, United Kingdom: Elsevier.

Journals

  • Hardy, R., Hulso, C., Liu, Y., Gasparini, S., Fong-Yee, C., Tu, J., Stoner, S., Stewart, P., Raza, K., Cooper, M., Seibel, M., Zhou, H. (2013). Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation. Arthritis Research and Therapy, 15(1), 1-14. [More Information]
  • Li, A., Hardy, R., Stoner, S., Tuckermann, J., Seibel, M., Zhou, H. (2013). Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure. PLoS One, 8(5), 1-11. [More Information]
  • Seibel, M., Cooper, M., Zhou, H. (2013). Glucocorticoid-induced osteoporosis: Mechanisms, management, and future perspectives. The Lancet Diabetes & Endocrinology, 1(1), 59-70. [More Information]
  • Zheng, Y., Zhou, H., Dunstan, C., Sutherland, R., Seibel, M. (2013). The role of the bone microenvironment in skeletal metastasis. Journal of Bone Oncology, 2(1), 47-57. [More Information]
  • Georgiou, K., King, T., Scherer, M., Zhou, H., Foster, B., Xian, C. (2012). Attenuated Wnt/beta-catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats. Bone, 50(6), 1223-1233. [More Information]
  • Speranza, T., Henneicke, H., Gasparini, S., Blankenstein, K., Heinevetter, U., Cogger, V., Svistounov, D., Zhang, Y., Cooney, G., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M., et al (2012). Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. Journal of Clinical Investigation, 122(11). [More Information]
  • Cooper, M., Zhou, H., Seibel, M. (2012). Selective glucocorticoid receptor agonists: Glucocorticoid therapy with no regrets? Journal of Bone and Mineral Research, 27(11), 2238-2241. [More Information]
  • Henneicke, H., Herrmann, M., Kalak, R., Speranza, T., Bertollo, N., Day, R., Huscher, D., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2011). Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism. Bone, 49(4), 733-742. [More Information]
  • Buttgereit, F., Burmester, G., Straub, R., Seibel, M., Zhou, H. (2011). Exogenous and endogenous glucocorticoids in rheumatic diseases. Arthritis and Rheumatism, 63(1), 1-9. [More Information]
  • Allan, C., Kalak, R., Dunstan, C., McTavish, K., Zhou, H., Handelsman, D., Seibel, M. (2010). Follicle-stimulating hormone increases bone mass in female mice. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, Published online before print December 13, 2010, 1-6. [More Information]
  • Liu, P., Kalak, R., Lue, Y., Jia, Y., Erkkila, K., Zhou, H., Seibel, M., Wang, C., Swerdloff, R., Dunstan, C. (2010). Genetic and Hormonal Control of Bone Volume, Architecture, and Remodeling in XXY Mice. Journal of Bone and Mineral Research, 25(10), 2148-2154. [More Information]
  • Simanainen, U., Lampinen, A., Henneicke, H., Speranza, T., Heinevetter, U., Harwood, D., McNamara, K., Herrmann, M., Seibel, M., Handelsman, D., Zhou, H. (2010). Long-Term Corticosterone Treatment Induced Lobe-Specific Pathology in Mouse Prostate. The Prostate, 71(3), 289-297. [More Information]
  • Weber, A., Li, G., Kalak, R., Street, J., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2010). Osteoblast-targeted disruption of glucocorticoid signalling does not delay intramembranous bone healing. Steroids, 75(3), 282-286. [More Information]
  • Ooi, L., Zheng, Y., Zhou, H., Trivedi, T., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis. Bone, 47(4), 795-803. [More Information]
  • Ooi, L., Zhou, H., Kalak, R., Zheng, Y., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Research, 70(5), 1835-1844. [More Information]
  • Zheng, Y., Zhou, H., Ooi, L., Snir, A., Dunstan, C., Seibel, M. (2010). Vitamin D deficiency promotes prostate cancer growth in bone. The Prostate, , 1-10. [More Information]
  • Mak, W., Shao, X., Dunstan, C., Seibel, M., Zhou, H. (2009). Biphasic Glucocorticoid-Dependent Regulation of Wnt Expression and Its Inhibitors in Mature Osteoblastic Cells. Calcified Tissue International, 85(6), 538-545. [More Information]
  • Kalak, R., Zhou, H., Street, J., Day, R., Modzelewski, J., Spies, C., Liu, P., Li, G., Dunstan, C., Seibel, M. (2009). Endogenous glucocorticoid signaling in osteoblasts is necessary to maintain normal bone structure in mice. Bone, 45(1), 61-67. [More Information]
  • Zhou, H., Mak, W., Kalak, R., Street, J., Fong-Yee, C., Zheng, Y., Dunstan, C., Seibel, M. (2009). Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice. Development (Cambridge), 136(3), 427-436. [More Information]
  • Herrmann, M., Henneicke, H., Street, J., Modzelewski, J., Kalak, R., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M. (2009). The challenge of continuous exogenous glucocorticoid administration in mice. Steroids, 74(2), 245-249. [More Information]
  • Buttgereit, F., Zhou, H., Kalak, R., Gaber, T., Spies, C., Huscher, D., Straub, R., Modzelewski, J., Dunstan, C., Seibel, M. (2009). Transgenic Disruption of Glucocorticoid Signaling in Mature Osteoblasts and Osteocytes Attenuates K/BxN Mouse Serum-Induced Arthritis In Vivo. Arthritis Care and Research, 60(7), 1998-2007. [More Information]
  • Buttgereit, F., Zhou, H., Seibel, M. (2008). Arthritis and endogenous glucocorticoids: the emerging role of the 11beta-HSD enzymes. Annals of the Rheumatic Diseases, 67(9), 1201-1203. [More Information]
  • Ramaswamy, Y., Wu, C., Zhou, H., Zreiqat, H. (2008). Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomaterialia, 4(5), 1487-1497. [More Information]
  • Zheng, Y., Zhou, H., Fong-Yee, C., Modzelewski, J., Seibel, M., Dunstan, C. (2008). Bone Resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis. Clinical and Experimental Metastasis, 25(5), 559-567. [More Information]
  • Zhou, H., Mak, W., Zheng, Y., Dunstan, C., Seibel, M. (2008). Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through WNT signaling. Journal of Biological Chemistry, 283(4), 1936-1945. [More Information]
  • Kartsogiannis, V., Sims, N., Quinn, J., Ly, C., Cipetic, M., Poulton, I., Walker, E., Saleh, H., Zhou, H., et al (2008). Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo. Journal of Biological Chemistry, 283(45), 30850-30860. [More Information]
  • Zheng, Y., Zhou, H., Modzelewski, J., Kalak, R., Blair, J., Seibel, M., Dunstan, C. (2007). Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone. Cancer Research, 67(19), 9542-9548. [More Information]
  • Blair, J., Zhou, H., Seibel, M., Dunstan, C. (2006). Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis. Nature Clinical Practice Oncology, 3(1), 41-49. [More Information]
  • Seibel, M., Dunstan, C., Zhou, H., Allan, C., Handelsman, D. (2006). Sex steroids, not FSH, influence bone mass. Cell, 127(6), 1079-1079. [More Information]
  • Dunstan, C., Zhou, H., Seibel, M. (2004). Fibroblast Growth Factor 23: A Phospatonin Regulating Phosphate Homeostasis? Endocrinology, 145(7), 3084-3086.

Conferences

  • Liu, P., Kalak, R., Lue, Y., Erkkilla, K., Simanainen, U., Zhou, H., Hikim, A., Handelsman, D., Seibel, M., Wang, C., Dunstan, C., et al (2007). XXY Mice have an Osteoporotic Phenotype. 29th Annual Meeting American Society for Bone and Mineral Research (ASBMR), Washington DC, USA: American Society for Bone and Mineral Research.
  • Kartsogiannis, V., Ly, C., Zhou, H., Gallagher, O., Buckle, C., De Leenheer, E., Vanderkerken, K., Ng, K., Martin, T., Gillespie, M., et al (2005). Expression of RANKL, OPG, PTHrP and OCIL in multiple myeloma are influenced by the tumor cells'' proximity to bone. 2005 Annual Meeting Of The American Society for Bone and Mineral Research, United States: American Society for Bone and Mineral Research.

Reference Works

  • Zhou, H., Chen, D., Dunstan, C., Seibel, M. (2009). Bone Metabolism. In Stefan Offermanns, Walter Rosenthal (Eds.), Bone Metabolism. (Vol. 1, pp. 276-282). USA: Springer.

2013

  • Hardy, R., Hulso, C., Liu, Y., Gasparini, S., Fong-Yee, C., Tu, J., Stoner, S., Stewart, P., Raza, K., Cooper, M., Seibel, M., Zhou, H. (2013). Characterisation of fibroblast-like synoviocytes from a murine model of joint inflammation. Arthritis Research and Therapy, 15(1), 1-14. [More Information]
  • Li, A., Hardy, R., Stoner, S., Tuckermann, J., Seibel, M., Zhou, H. (2013). Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure. PLoS One, 8(5), 1-11. [More Information]
  • Seibel, M., Cooper, M., Zhou, H. (2013). Glucocorticoid-induced osteoporosis: Mechanisms, management, and future perspectives. The Lancet Diabetes & Endocrinology, 1(1), 59-70. [More Information]
  • Zheng, Y., Zhou, H., Dunstan, C., Sutherland, R., Seibel, M. (2013). The role of the bone microenvironment in skeletal metastasis. Journal of Bone Oncology, 2(1), 47-57. [More Information]

2012

  • Georgiou, K., King, T., Scherer, M., Zhou, H., Foster, B., Xian, C. (2012). Attenuated Wnt/beta-catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats. Bone, 50(6), 1223-1233. [More Information]
  • Speranza, T., Henneicke, H., Gasparini, S., Blankenstein, K., Heinevetter, U., Cogger, V., Svistounov, D., Zhang, Y., Cooney, G., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M., et al (2012). Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism. Journal of Clinical Investigation, 122(11). [More Information]
  • Cooper, M., Zhou, H., Seibel, M. (2012). Selective glucocorticoid receptor agonists: Glucocorticoid therapy with no regrets? Journal of Bone and Mineral Research, 27(11), 2238-2241. [More Information]

2011

  • Henneicke, H., Herrmann, M., Kalak, R., Speranza, T., Bertollo, N., Day, R., Huscher, D., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2011). Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism. Bone, 49(4), 733-742. [More Information]
  • Buttgereit, F., Burmester, G., Straub, R., Seibel, M., Zhou, H. (2011). Exogenous and endogenous glucocorticoids in rheumatic diseases. Arthritis and Rheumatism, 63(1), 1-9. [More Information]
  • Zheng, Y., Seibel, M., Zhou, H. (2011). Methods in Bone Biology: Cancer and Bone. In Gustavo Duque, Ken Watanabe (Eds.), Osteoporosis Research: Animal Models, (pp. 83-91). London: Springer.

2010

  • Allan, C., Kalak, R., Dunstan, C., McTavish, K., Zhou, H., Handelsman, D., Seibel, M. (2010). Follicle-stimulating hormone increases bone mass in female mice. Proceedings of the National Academy of Sciences (PNAS) of the United States of America, Published online before print December 13, 2010, 1-6. [More Information]
  • Liu, P., Kalak, R., Lue, Y., Jia, Y., Erkkila, K., Zhou, H., Seibel, M., Wang, C., Swerdloff, R., Dunstan, C. (2010). Genetic and Hormonal Control of Bone Volume, Architecture, and Remodeling in XXY Mice. Journal of Bone and Mineral Research, 25(10), 2148-2154. [More Information]
  • Simanainen, U., Lampinen, A., Henneicke, H., Speranza, T., Heinevetter, U., Harwood, D., McNamara, K., Herrmann, M., Seibel, M., Handelsman, D., Zhou, H. (2010). Long-Term Corticosterone Treatment Induced Lobe-Specific Pathology in Mouse Prostate. The Prostate, 71(3), 289-297. [More Information]
  • Weber, A., Li, G., Kalak, R., Street, J., Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H. (2010). Osteoblast-targeted disruption of glucocorticoid signalling does not delay intramembranous bone healing. Steroids, 75(3), 282-286. [More Information]
  • Ooi, L., Zheng, Y., Zhou, H., Trivedi, T., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes growth of MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis. Bone, 47(4), 795-803. [More Information]
  • Ooi, L., Zhou, H., Kalak, R., Zheng, Y., Conigrave, A., Seibel, M., Dunstan, C. (2010). Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Research, 70(5), 1835-1844. [More Information]
  • Zheng, Y., Zhou, H., Ooi, L., Snir, A., Dunstan, C., Seibel, M. (2010). Vitamin D deficiency promotes prostate cancer growth in bone. The Prostate, , 1-10. [More Information]

2009

  • Mak, W., Shao, X., Dunstan, C., Seibel, M., Zhou, H. (2009). Biphasic Glucocorticoid-Dependent Regulation of Wnt Expression and Its Inhibitors in Mature Osteoblastic Cells. Calcified Tissue International, 85(6), 538-545. [More Information]
  • Zhou, H., Chen, D., Dunstan, C., Seibel, M. (2009). Bone Metabolism. In Stefan Offermanns, Walter Rosenthal (Eds.), Bone Metabolism. (Vol. 1, pp. 276-282). USA: Springer.
  • Kalak, R., Zhou, H., Street, J., Day, R., Modzelewski, J., Spies, C., Liu, P., Li, G., Dunstan, C., Seibel, M. (2009). Endogenous glucocorticoid signaling in osteoblasts is necessary to maintain normal bone structure in mice. Bone, 45(1), 61-67. [More Information]
  • Zhou, H., Mak, W., Kalak, R., Street, J., Fong-Yee, C., Zheng, Y., Dunstan, C., Seibel, M. (2009). Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice. Development (Cambridge), 136(3), 427-436. [More Information]
  • Herrmann, M., Henneicke, H., Street, J., Modzelewski, J., Kalak, R., Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M. (2009). The challenge of continuous exogenous glucocorticoid administration in mice. Steroids, 74(2), 245-249. [More Information]
  • Buttgereit, F., Zhou, H., Kalak, R., Gaber, T., Spies, C., Huscher, D., Straub, R., Modzelewski, J., Dunstan, C., Seibel, M. (2009). Transgenic Disruption of Glucocorticoid Signaling in Mature Osteoblasts and Osteocytes Attenuates K/BxN Mouse Serum-Induced Arthritis In Vivo. Arthritis Care and Research, 60(7), 1998-2007. [More Information]

2008

  • Buttgereit, F., Zhou, H., Seibel, M. (2008). Arthritis and endogenous glucocorticoids: the emerging role of the 11beta-HSD enzymes. Annals of the Rheumatic Diseases, 67(9), 1201-1203. [More Information]
  • Ramaswamy, Y., Wu, C., Zhou, H., Zreiqat, H. (2008). Biological response of human bone cells to zinc-modified Ca-Si-based ceramics. Acta Biomaterialia, 4(5), 1487-1497. [More Information]
  • Zheng, Y., Zhou, H., Fong-Yee, C., Modzelewski, J., Seibel, M., Dunstan, C. (2008). Bone Resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis. Clinical and Experimental Metastasis, 25(5), 559-567. [More Information]
  • Zhou, H., Mak, W., Zheng, Y., Dunstan, C., Seibel, M. (2008). Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through WNT signaling. Journal of Biological Chemistry, 283(4), 1936-1945. [More Information]
  • Kartsogiannis, V., Sims, N., Quinn, J., Ly, C., Cipetic, M., Poulton, I., Walker, E., Saleh, H., Zhou, H., et al (2008). Osteoclast inhibitory lectin, an immune cell product that is required for normal bone physiology in vivo. Journal of Biological Chemistry, 283(45), 30850-30860. [More Information]

2007

  • Zheng, Y., Zhou, H., Modzelewski, J., Kalak, R., Blair, J., Seibel, M., Dunstan, C. (2007). Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone. Cancer Research, 67(19), 9542-9548. [More Information]
  • Dunstan, C., Blair, J., Zhou, H., Seibel, M. (2007). Bone, Mineral, Connective Tissue Metabolism. In Taylor J; Triggle D (vol ed Michael Williams) (Eds.), Comprehensive Medicinal Chemistry II, (pp. 495-520). Oxford, United Kingdom: Elsevier.
  • Liu, P., Kalak, R., Lue, Y., Erkkilla, K., Simanainen, U., Zhou, H., Hikim, A., Handelsman, D., Seibel, M., Wang, C., Dunstan, C., et al (2007). XXY Mice have an Osteoporotic Phenotype. 29th Annual Meeting American Society for Bone and Mineral Research (ASBMR), Washington DC, USA: American Society for Bone and Mineral Research.

2006

  • Blair, J., Zhou, H., Seibel, M., Dunstan, C. (2006). Mechanisms of disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis. Nature Clinical Practice Oncology, 3(1), 41-49. [More Information]
  • Seibel, M., Dunstan, C., Zhou, H., Allan, C., Handelsman, D. (2006). Sex steroids, not FSH, influence bone mass. Cell, 127(6), 1079-1079. [More Information]

2005

  • Kartsogiannis, V., Ly, C., Zhou, H., Gallagher, O., Buckle, C., De Leenheer, E., Vanderkerken, K., Ng, K., Martin, T., Gillespie, M., et al (2005). Expression of RANKL, OPG, PTHrP and OCIL in multiple myeloma are influenced by the tumor cells'' proximity to bone. 2005 Annual Meeting Of The American Society for Bone and Mineral Research, United States: American Society for Bone and Mineral Research.

2004

  • Dunstan, C., Zhou, H., Seibel, M. (2004). Fibroblast Growth Factor 23: A Phospatonin Regulating Phosphate Homeostasis? Endocrinology, 145(7), 3084-3086.

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