Dr Justin Wong

Senior Research Fellow
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone 02 9565 6262

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Biographical details

Dr. Justin Wong is a Faculty member and head of the Epigenetics and RNA Biology Program at the Centenary Institute. He currently holds a Career Development Fellowship awarded by the Cancer Institute of NSW. He completed his PhD in the area of cancer epigenetics in the laboratory of Professor Robyn Ward at the University of New South Wales. HisProgram focus ondeciphering novel gene regulation mechanisms in normal biology and cancer. He is passionate aboutdetermining the control of processes such as alternative splicing and RNA modification in cells. His vision is to acquireknowledge concerning epigenetic changes, alternative splicing and RNA modification, which may be useful for thedevelopment of novel therapies for human diseases, especially cancers.

Research interests

Dr. Justin Wong has a very strong interest in gene expression regulation. Having completed his PhD with high profile papers related to germline epimutation and cancers (New England Journal of Medicine, Cancer Cell, Gut), he joined Professor John Rasko's Program at the Centenary Institue to study the role of non-coding RNA and gene expression in the development of white blood cells. His current research topics are:

1. The mechanisms of intron retention in the development of white blood cells (Follow-up of his recent paper in Cell).

2. The role of aberrant splicing factor expression in myelodysplasia and acute myeloid leukaemia.

3. The roles of RNA modifications in white blood cell differentiation and cancer.

Teaching and supervision

Honours and Postgraduate Research supervision

Selected grants

2018

  • Defining the role of aberrant splicing (intron retention) in the development and maintenance of acute myeloid leukaemia; Wong J, Rasko J; Cancer Institute NSW/Career Development Fellowship.
  • New Initiatives in Basic and Applied Medical Research; Rasko J, Bailey C, Wong J, Schmitz U; Philip Bushell Foundation/Research Support.

2017

  • Deciphering the role of DNA methylation in the regulation of alternative splicing; Lister R, Wong J, Rasko J; National Health and Medical Research Council (NHMRC)/Project Grants.

2015

  • Investigating widespread regulation of gene expression through intron retention; Rasko J, Ritchie W, Wong J; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • Linking mutations and epigenetic silencing of splicing factors to aberrant splicing in acute myeloid leukaemia; Wong J; Cancer Institute NSW/Early Career Fellowship.

Selected publications

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Journals

  • Roediger, B., Lee, Q., Tikoo, S., Cobbin, J., Henderson, J., Jormakka, M., O'Rourke, M., Padula, M., Pinello, N., Henry, M., Wynne, M., Lisowski, L., Tay, S., Harris, D., Bertolino, P., Wong, J., Gorrell, M., Holmes, E., Jolly, C., Weninger, W., et al (2018). An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis. Cell, 175(2), 530-540. [More Information]
  • Vanichkina, D., Schmitz, U., Wong, J., Rasko, J. (2018). Challenges in defining the role of intron retention in normal biology and disease. Seminars in Cell and Developmental Biology, 75, 40-49. [More Information]
  • Nair, S., Luu, P., Qu, W., Maddugoda, M., Huschtscha, L., Reddel, R., Chenevix-Trench, G., Toso, M., Kench, J., Horvath, L., Hayes, V., Rasko, J., Wong, J., et al (2018). Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten. Epigenetics & Chromatin, 11(1), 1-20. [More Information]
  • Rajasekhar, M., Schmitz, U., Flamant, S., Wong, J., Bailey, C., Ritchie, W., Holst, J., Rasko, J. (2018). Identifying microRNA determinants of human myelopoiesis. Scientific Reports, 8(1), 7264. [More Information]
  • Wong, A., Rasko, J., Wong, J. (2018). We skip to work: alternative splicing in normal and malignant myelopoiesis. Leukemia, 32(5), 1081-1093. [More Information]
  • Kwok, C., Marshall, A., Rasko, J., Wong, J. (2017). Genetic alterations of m(6)A regulators predict poorer survival in acute myeloid leukemia. Journal of Hematology and Oncology, 10(1), 39. [More Information]
  • Schmitz, U., Pinello, N., Jia, F., Alasmari, S., Ritchie, W., Keightley, M., Shini, S., Lieschke, G., Wong, J., Rasko, J. (2017). Intron retention enhances gene regulatory complexity in vertebrates. Genome Biology, 18(1), 1-15. [More Information]
  • Wong, J., Gao, D., Nguyen, T., Kwok, C., Van Geldermalsen, M., Middleton, R., Pinello, N., Thoeng, A., Nagarajah, R., Holst, J., Ritchie, W., Rasko, J. (2017). Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment. Nature Communications, 8, 1-13. [More Information]
  • Middleton, R., Gao, D., Thomas, A., Singh, B., Au, A., Wong, J., Bomane, A., Cosson, B., Eyras, E., Rasko, J., et al (2017). IRFinder: Assessing the impact of intron retention on mammalian gene expression. Genome Biology, 18(1), 1-11. [More Information]
  • Rasko, J., Wong, J. (2017). Nuclear microRNAs in normal hemopoiesis and cancer. Journal of Hematology and Oncology, 10(1), 1-8. [More Information]
  • Tan, M., Widagdo, J., Chau, Y., Zhu, T., Wong, J., Cheung, A., Anggono, V. (2017). The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons. Frontiers in Cellular Neuroscience, 11, 1-12. [More Information]
  • Edwards, C., Ritchie, W., Wong, J., Schmitz, U., Middleton, R., An, X., Mohandas, N., Rasko, J., Blobel, G. (2016). A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages. Blood, 127(17), e24-e34. [More Information]
  • Wong, J., Au, A., Ritchie, W., Rasko, J. (2016). Intron retention in mRNA: No longer nonsense: Known and putative roles of intron retention in normal and disease biology. BioEssays, 38(1), 41-49. [More Information]
  • Wong, J., Au, A., Gao, D., Pinello, N., Kwok, C., Thoeng, A., Lau, K., Gordon, J., Schmitz, U., Feng, Y., Nguyen, T., Middleton, R., Bailey, C., Holst, J., Rasko, J., Ritchie, W. (2016). RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever. Nucleic Acids Research, 44(6), 2888-2897. [More Information]
  • Wang, K., Hardie, R., Hoy, A., van Geldermalsen, M., Gao, D., Fazli, L., Sadowski, M., Balaban, S., Schreuder, M., Nagarajah, R., Wong, J., Metierre, C., Pinello, N., Otte, N., Bailey, C., Ritchie, W., Rasko, J., Holst, J., et al (2015). Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development. Journal of Pathology, 236(3), 278-289. [More Information]
  • Wong, J., Lau, K., Pinello, N., Rasko, J. (2014). Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia. Cancer science, 105(11), 1457-1463. [More Information]
  • Wong, J., Ritchie, W., Gao, D., Lau, K., Gonzalez, M., Choudhary, A., Taft, R., Rasko, J., Holst, J. (2014). Identification of nuclear-enriched miRNAs during mouse granulopoiesis. Journal of Hematology and Oncology, 7(1), 1-15. [More Information]
  • Clancy, J., Patel, H., Hussein, S., Tonge, P., Cloonan, N., Corso, A., Li, M., Lee, D., Shin, J., Wong, J., Bailey, C., Rasko, J., et al (2014). Small RNA changes en route to distinct cellular states of induced pluripotency. Nature Communications, 5, 1-9. [More Information]
  • Lau, K., Wong, J. (2013). Current trends of HIV recombination worldwide. Infectious Disease Reports, 5(Suppl 1), 15-20. [More Information]
  • Wong, J., Ritchie, W., Ebner, O., Selbach, M., Wong, J., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., Thoeng, A., Khoo, T., Bailey, C., Holst, J., Rasko, J. (2013). Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation. Cell, 154(3), 583-595. [More Information]

2018

  • Roediger, B., Lee, Q., Tikoo, S., Cobbin, J., Henderson, J., Jormakka, M., O'Rourke, M., Padula, M., Pinello, N., Henry, M., Wynne, M., Lisowski, L., Tay, S., Harris, D., Bertolino, P., Wong, J., Gorrell, M., Holmes, E., Jolly, C., Weninger, W., et al (2018). An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis. Cell, 175(2), 530-540. [More Information]
  • Vanichkina, D., Schmitz, U., Wong, J., Rasko, J. (2018). Challenges in defining the role of intron retention in normal biology and disease. Seminars in Cell and Developmental Biology, 75, 40-49. [More Information]
  • Nair, S., Luu, P., Qu, W., Maddugoda, M., Huschtscha, L., Reddel, R., Chenevix-Trench, G., Toso, M., Kench, J., Horvath, L., Hayes, V., Rasko, J., Wong, J., et al (2018). Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten. Epigenetics & Chromatin, 11(1), 1-20. [More Information]
  • Rajasekhar, M., Schmitz, U., Flamant, S., Wong, J., Bailey, C., Ritchie, W., Holst, J., Rasko, J. (2018). Identifying microRNA determinants of human myelopoiesis. Scientific Reports, 8(1), 7264. [More Information]
  • Wong, A., Rasko, J., Wong, J. (2018). We skip to work: alternative splicing in normal and malignant myelopoiesis. Leukemia, 32(5), 1081-1093. [More Information]

2017

  • Kwok, C., Marshall, A., Rasko, J., Wong, J. (2017). Genetic alterations of m(6)A regulators predict poorer survival in acute myeloid leukemia. Journal of Hematology and Oncology, 10(1), 39. [More Information]
  • Schmitz, U., Pinello, N., Jia, F., Alasmari, S., Ritchie, W., Keightley, M., Shini, S., Lieschke, G., Wong, J., Rasko, J. (2017). Intron retention enhances gene regulatory complexity in vertebrates. Genome Biology, 18(1), 1-15. [More Information]
  • Wong, J., Gao, D., Nguyen, T., Kwok, C., Van Geldermalsen, M., Middleton, R., Pinello, N., Thoeng, A., Nagarajah, R., Holst, J., Ritchie, W., Rasko, J. (2017). Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment. Nature Communications, 8, 1-13. [More Information]
  • Middleton, R., Gao, D., Thomas, A., Singh, B., Au, A., Wong, J., Bomane, A., Cosson, B., Eyras, E., Rasko, J., et al (2017). IRFinder: Assessing the impact of intron retention on mammalian gene expression. Genome Biology, 18(1), 1-11. [More Information]
  • Rasko, J., Wong, J. (2017). Nuclear microRNAs in normal hemopoiesis and cancer. Journal of Hematology and Oncology, 10(1), 1-8. [More Information]
  • Tan, M., Widagdo, J., Chau, Y., Zhu, T., Wong, J., Cheung, A., Anggono, V. (2017). The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons. Frontiers in Cellular Neuroscience, 11, 1-12. [More Information]

2016

  • Edwards, C., Ritchie, W., Wong, J., Schmitz, U., Middleton, R., An, X., Mohandas, N., Rasko, J., Blobel, G. (2016). A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages. Blood, 127(17), e24-e34. [More Information]
  • Wong, J., Au, A., Ritchie, W., Rasko, J. (2016). Intron retention in mRNA: No longer nonsense: Known and putative roles of intron retention in normal and disease biology. BioEssays, 38(1), 41-49. [More Information]
  • Wong, J., Au, A., Gao, D., Pinello, N., Kwok, C., Thoeng, A., Lau, K., Gordon, J., Schmitz, U., Feng, Y., Nguyen, T., Middleton, R., Bailey, C., Holst, J., Rasko, J., Ritchie, W. (2016). RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever. Nucleic Acids Research, 44(6), 2888-2897. [More Information]

2015

  • Wang, K., Hardie, R., Hoy, A., van Geldermalsen, M., Gao, D., Fazli, L., Sadowski, M., Balaban, S., Schreuder, M., Nagarajah, R., Wong, J., Metierre, C., Pinello, N., Otte, N., Bailey, C., Ritchie, W., Rasko, J., Holst, J., et al (2015). Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development. Journal of Pathology, 236(3), 278-289. [More Information]

2014

  • Wong, J., Lau, K., Pinello, N., Rasko, J. (2014). Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia. Cancer science, 105(11), 1457-1463. [More Information]
  • Wong, J., Ritchie, W., Gao, D., Lau, K., Gonzalez, M., Choudhary, A., Taft, R., Rasko, J., Holst, J. (2014). Identification of nuclear-enriched miRNAs during mouse granulopoiesis. Journal of Hematology and Oncology, 7(1), 1-15. [More Information]
  • Clancy, J., Patel, H., Hussein, S., Tonge, P., Cloonan, N., Corso, A., Li, M., Lee, D., Shin, J., Wong, J., Bailey, C., Rasko, J., et al (2014). Small RNA changes en route to distinct cellular states of induced pluripotency. Nature Communications, 5, 1-9. [More Information]

2013

  • Lau, K., Wong, J. (2013). Current trends of HIV recombination worldwide. Infectious Disease Reports, 5(Suppl 1), 15-20. [More Information]
  • Wong, J., Ritchie, W., Ebner, O., Selbach, M., Wong, J., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., Thoeng, A., Khoo, T., Bailey, C., Holst, J., Rasko, J. (2013). Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation. Cell, 154(3), 583-595. [More Information]

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