People_

Dr Justin Wong

Senior Lecturer
School of Medical Sciences
Faculty of Medicine and Health

Phone

02 86277434

Email

justin.wong@sydney.edu.au

Details

Member of the Charles Perkins Centre

Biographical details

Dr. Justin Wong is a Senior Lecturer at the School of Medical Sciences, Faculty of Medicine and Health, the University of Sydney. He was formerly a Faculty member and head of the Epigenetics and RNA Biology Program at the Centenary Institute from 2018-2023. He has over 15 years of experience in epigenetic and RNA biology research, which focuses mainly on understanding how these key molecular mechanisms govern cellular differentiation, and how aberrancies in these mechanisms lead to diseases including cancer and inflammatory disorders.He is passionate to determine the crosstalk between alternative splicing and modifications to RNA in normal physiology and disease development. His passion is to provide new insights into these fundamental biological mechanisms, which can be targeted to improve health.

Research interests

Dr. Justin Wong has a very strong interest in gene expression regulation. Having completed his PhD with high profile papers related to germline epimutation and cancers (New England Journal of Medicine, Cancer Cell, Gut), he has studied the role of non-coding RNA, RNA modifications and alternative splicing in normal physiology and disease. His current research topics are:

1. The mechanisms of intron retention in the development of white blood cells (Follow-up of his paper in Cell, Nature Communications, Nucleic Acids Research, Immunology).

2. The role of intron retention in acute myeloid leukaemia.

3. The role of RNA modification in white blood cell differentiation and cancer.

4. The role of RNA modification in macrophage development and function.

5. The role of RNA modification in smooth muscle cell plasticity.

Teaching and supervision

Lecturer for PHSI3X12

Honours and Postgraduate Research supervision

Themes

Cancer, Infection and Immunological Conditions

Keywords

Cancer, Cell biology, Haematological malignancy, Molecular biology, Epigenetics

Approaches

Cellular/Molecular, Genetics, Immunology

Publications

By Type

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Journals

Pinello, N., Song, R., Lee, Q., Calonne, E., Larance, M., Fuks, F., Wong, J. (2024). A multiomics dataset for the study of RNA modifications in human macrophage differentiation and polarisation. Scientific Data, 11(1). [More Information]
Wu, S., Wang, X., Xia, Y., Liu, R., Alexander, S., Wong, J., Zhang, Y., Zheng, X., Feng, Y., Song, R., et al (2024). Foxp1 Is Required for Renal Intercalated Cell Differentiation and Acid-Base Regulation. Journal of the American Society of Nephrology, 35(5), 533-548. [More Information]
Shen, C., Feng, S., Hao, Y., Zhao, A., Kirkby, M., Kurera, M., Zhang, J., Venkataraman, S., Liu, C., Song, R., Wong, J., Schumann, U., et al (2024). Inflammasome protein scaffolds the DNA damage complex during tumor development. Nature Immunology. [More Information]
Pandey, A., Shen, C., Feng, S., Enosi Tuipulotu, D., Ngo, C., Liu, C., Kurera, M., Mathur, A., Venkataraman, S., Zhang, J., Song, R., Wong, J., et al (2024). Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome. Science Advances, 10(4). [More Information]
Wong, A., Wong, J., Rasko, J., Schmitz, U. (2024). SpliceWiz: interactive analysis and visualization of alternative splicing in R. Briefings in Bioinformatics, 25(1), bbad468. [More Information]
Zhang, J., Yang, J., Duval, C., Edin, M., Williams, A., Lei, L., Tu, M., Pourmand, E., Song, R., Graves, J., Wong, J., et al (2023). CYP eicosanoid pathway mediates colon cancer-promoting effects of dietary linoleic acid. The FASEB Journal, 37(7), e23009. [More Information]
Wang, R., Zhao, Q., Liu, R., Zheng, X., Lu, D., Song, R., Du, L., Yang, X., Wu, S., Wang, X., Wong, J., et al (2023). Epicardial CCM2 Promotes Cardiac Development and Repair Via its Regulation on Cytoskeletal Reorganization. JACC: Basic to Translational Science. [More Information]
Hitchins, M., Alvarez, R., Zhou, L., Aguirre, F., Dámaso, E., Pineda, M., Capella, G., Wong, J., Yuan, X., Ryan, S., et al (2023). MLH1-methylated endometrial cancer under 60 years of age as the “sentinel” cancer in female carriers of high-risk constitutional MLH1 epimutation. Gynecologic Oncology, 171, 129-140. [More Information]
Huang, H., Song, R., Wong, J., Anggono, V., Widagdo, J. (2023). The N6-methyladenosine RNA landscape in the aged mouse hippocampus. Aging Cell, 22(1). [More Information]
Song, R., Wong, J. (2022). Altered expression of m1A regulatory genes is associated with oncogenic pathways, overall survival, and infiltration of immune cells in diverse human cancers. Genes & Diseases. [More Information]
Song, R., Tikoo, S., Jain, R., Pinello, N., Au, A., Nagarajah, R., Porse, B., Rasko, J., Wong, J. (2022). Dynamic intron retention modulates gene expression in the monocytic differentiation pathway. Immunology, 165(2), 274-286. [More Information]
Petrova, V., Song, R., Nordström, K., Walter, J., Wong, J., Armstrong, N., Rasko, J., Schmitz, U. (2022). Increased chromatin accessibility facilitates intron retention in specific cell differentiation states. Nucleic Acids Research, 50(20), 11563-11579. [More Information]
Wong, J., Schmitz, U. (2022). Intron retention: importance, challenges, and opportunities. Trends in Genetics, 38(8), 789-792. [More Information]
Zhu, S., Rao, X., Qian, Y., Chen, J., Song, R., Yan, H., Yang, X., Hu, J., Wang, X., Han, Z., Wong, J., McCaughan, G., et al (2022). Liver Endothelial Heg Regulates Vascular/Biliary Network Patterning and Metabolic Zonation Via Wnt Signaling. Cellular and Molecular Gastroenterology and Hepatology, 13(6), 1757-1783. [More Information]
Hortle, E., Tran, V., Wright, K., Fontaine, A., Pinello, N., O'Rourke, M., Wong, J., Hansbro, P., Britton, W., Oehlers, S. (2022). OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection. Life Science Alliance, 5(9), e202201476. [More Information]
Widagdo, J., Wong, J., Anggono, V. (2022). The m6A-epitranscriptome in brain plasticity, learning and memory. Seminars in Cell & Developmental Biology, 125, 110-121. [More Information]
Widagdo, J., Anggono, V., Wong, J. (2022). The multifaceted effects of YTHDC1-mediated nuclear m6A recognition. Trends in Genetics, 38(4), 325-332. [More Information]
Shah, J., Milevskiy, M., Petrova, V., Au, A., Wong, J., Visvader, J., Schmitz, U., Rasko, J. (2022). Towards resolution of the intron retention paradox in breast cancer. Breast Cancer Research, 24(1). [More Information]
Chen, X., Zhou, W., Song, R., Liu, S., Wang, S., Chen, Y., Gao, C., He, C., Xiao, J., Zhang, L., Wong, J., et al (2022). Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity. Science Advances, 8(4), eabl5220. [More Information]
Choi, J., Yang, X., He, S., Song, R., Xu, Z., Foley, M., Wong, J., Xu, C., Zheng, X. (2021). CCM2L (Cerebral Cavernous Malformation 2 Like) Deletion Aggravates Cerebral Cavernous Malformation Through Map3k3-KLF Signaling Pathway. Stroke, 52(4), 1428-1436. [More Information]
Alharbi, A., Schmitz, U., Marshall, A., Vanichkina, D., Nagarajah, R., Vellozzi, M., Wong, J., Bailey, C., Rasko, J. (2021). Ctcf haploinsufficiency mediates intron retention in a tissue-specific manner. RNA Biology, 18(1), 93-103. [More Information]
Wang, R., Wu, S., Yang, X., Qian, Y., Choi, J., Gao, R., Song, S., Wang, Y., Zhuang, T., Wong, J., Alexander, S., et al (2021). Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting. JCI Insight, 6(12), e142838. [More Information]
Green, I., Liu, R., Wong, J. (2021). The expanding role of alternative splicing in vascular smooth muscle cell plasticity. International Journal of Molecular Sciences, 22(19), 10213. [More Information]
Lan, J., Rajan, N., Bizet, M., Penning, A., Singh, N., Guallar, D., Calonne, E., Li Greci, A., Bonvin, E., Deplus, R., Song, R., Wong, J., et al (2020). Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation. Nature Communications, 11(1), 1-15. [More Information]
Li, X., Li, N., Huang, L., Xu, S., Zheng, X., Hamsath, A., Zhang, M., Dai, L., Zhang, H., Wong, J., et al (2020). Is Hydrogen Sulfide a Concern During Treatment of Lung Adenocarcinoma With Ammonium Tetrathiomolybdate? Frontiers in Oncology, 10, 234. [More Information]
Green, I., Pinello, N., Song, R., Lee, Q., Halstead, J., Kwok, C., Wong, A., Nair, S., Clark, S., Roediger, B., Schmitz, U., Larance, M., Rasko, J., Wong, J., et al (2020). Macrophage development and activation involve coordinated intron retention in key inflammatory regulators. Nucleic Acids Research, 48(12), 6513-6529. [More Information]
Lee, Q., Padula, M., Pinello, N., Williams, S., O'Rourke, M., Fumagalli, M., Orkin, J., Song, R., Shaban, B., Brenner, O., Weninger, W., Wong, J., Roediger, B., et al (2020). Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys. PLoS Pathogens, 16(1), e1008262. [More Information]
Schmitz, U., Shah, J., Dhungel, B., Monteuuis, G., Luu, P., Petrova, V., Metierre, C., Nair, S., Bailey, C., Saunders, V., Wong, J., Rasko, J., et al (2020). Widespread aberrant alternative splicing despite molecular remission in chronic myeloid leukaemia patients. Cancers, 12(12), 1-19. [More Information]
Gao, D., Pinello, N., Nguyen, T., Thoeng, A., Nagarajah, R., Holst, J., Rasko, J., Wong, J. (2019). DNA methylation/hydroxymethylation regulate gene expression and alternative splicing during terminal granulopoiesis. Epigenomics, 11(1), 95-109. [More Information]
Monteuuis, G., Wong, J., Bailey, C., Schmitz, U., Rasko, J. (2019). The changing paradigm of intron retention: regulation, ramifications and recipes. Nucleic Acids Research, 47(22), 11497-11513. [More Information]
Pinello, N., Sun, S., Wong, J. (2018). Aberrant expression of enzymes regulating m 6 A mRNA methylation: implication in cancer. Cancer Biology & Medicine, 15(4), 323-334. [More Information]
Roediger, B., Lee, Q., Tikoo, S., Cobbin, J., Henderson, J., Jormakka, M., O'Rourke, M., Padula, M., Pinello, N., Henry, M., Wynne, M., Lisowski, L., Tay, S., Harris, D., Bertolino, P., Wong, J., Gorrell, M., Holmes, E., Jolly, C., Weninger, W., et al (2018). An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis. Cell, 175(2), 530-540. [More Information]
Vanichkina, D., Schmitz, U., Wong, J., Rasko, J. (2018). Challenges in defining the role of intron retention in normal biology and disease. Seminars in Cell and Developmental Biology, 75, 40-49. [More Information]
Cook, S., Lee, Q., Wong, A., Spann, B., Vincent, J., Wong, J., Schlitzer, A., Gorrell, M., Weninger, W., Roediger, B. (2018). Differential chemokine receptor expression and usage by pre-cDC1 and pre-cDC2. Immunology and Cell Biology, 96(10), 1131-1139. [More Information]
Nair, S., Luu, P., Qu, W., Maddugoda, M., Huschtscha, L., Reddel, R., Chenevix-Trench, G., Toso, M., Kench, J., Horvath, L., Hayes, V., Rasko, J., Wong, J., et al (2018). Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten. Epigenetics & Chromatin, 11(1), 1-20. [More Information]
Rajasekhar, M., Schmitz, U., Flamant, S., Wong, J., Bailey, C., Ritchie, W., Holst, J., Rasko, J. (2018). Identifying microRNA determinants of human myelopoiesis. Scientific Reports, 8(1), 1-15. [More Information]
Wong, A., Rasko, J., Wong, J. (2018). We skip to work: alternative splicing in normal and malignant myelopoiesis. Leukemia, 32(5), 1081-1093. [More Information]
Kwok, C., Marshall, A., Rasko, J., Wong, J. (2017). Genetic alterations of m(6)A regulators predict poorer survival in acute myeloid leukemia. Journal of Hematology and Oncology, 10(1), 39. [More Information]
Schmitz, U., Pinello, N., Jia, F., Alasmari, S., Ritchie, W., Keightley, M., Shini, S., Lieschke, G., Wong, J., Rasko, J. (2017). Intron retention enhances gene regulatory complexity in vertebrates. Genome Biology, 18(1), 1-15. [More Information]
Wong, J., Gao, D., Nguyen, T., Kwok, C., van Geldermalsen, M., Middleton, R., Pinello, N., Thoeng, A., Nagarajah, R., Holst, J., Ritchie, W., Rasko, J. (2017). Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment. Nature Communications, 8, 1-13. [More Information]
Middleton, R., Gao, D., Thomas, A., Singh, B., Au, A., Wong, J., Bomane, A., Cosson, B., Eyras, E., Rasko, J., et al (2017). IRFinder: Assessing the impact of intron retention on mammalian gene expression. Genome Biology, 18(1), 1-11. [More Information]
Rasko, J., Wong, J. (2017). Nuclear microRNAs in normal hemopoiesis and cancer. Journal of Hematology and Oncology, 10(1), 1-8. [More Information]
Tan, M., Widagdo, J., Chau, Y., Zhu, T., Wong, J., Cheung, A., Anggono, V. (2017). The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons. Frontiers in Cellular Neuroscience, 11, 1-12. [More Information]
Edwards, C., Ritchie, W., Wong, J., Schmitz, U., Middleton, R., An, X., Mohandas, N., Rasko, J., Blobel, G. (2016). A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages. Blood, 127(17), e24-e34. [More Information]
Wong, J., Au, A., Ritchie, W., Rasko, J. (2016). Intron retention in mRNA: No longer nonsense: Known and putative roles of intron retention in normal and disease biology. BioEssays, 38(1), 41-49. [More Information]
Wong, J., Au, A., Gao, D., Pinello, N., Kwok, C., Thoeng, A., Lau, K., Gordon, J., Schmitz, U., Feng, Y., Nguyen, T., Middleton, R., Bailey, C., Holst, J., Rasko, J., Ritchie, W. (2016). RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever. Nucleic Acids Research, 44(6), 2888-2897. [More Information]
Wang, Q., Hardie, R., Hoy, A., van Geldermalsen, M., Gao, D., Fazli, L., Sadowski, M., Balaban, S., Schreuder, M., Nagarajah, R., Wong, J., Metierre, C., Pinello, N., Otte, N., Bailey, C., Ritchie, W., Rasko, J., Holst, J., et al (2015). Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development. Journal of Pathology, 236(3), 278-289. [More Information]
Wong, J., Lau, K., Pinello, N., Rasko, J. (2014). Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia. Cancer Science, 105(11), 1457-1463. [More Information]
Wong, J., Ritchie, W., Gao, D., Lau, K., Gonzalez, M., Choudhary, A., Taft, R., Rasko, J., Holst, J. (2014). Identification of nuclear-enriched miRNAs during mouse granulopoiesis. Journal of Hematology and Oncology, 7(1), 1-15. [More Information]
Clancy, J., Patel, H., Hussein, S., Tonge, P., Cloonan, N., Corso, A., Li, M., Lee, D., Shin, J., Wong, J., Bailey, C., Rasko, J., et al (2014). Small RNA changes en route to distinct cellular states of induced pluripotency. Nature Communications, 5, 1-9. [More Information]
Lau, K., Wong, J. (2013). Current trends of HIV recombination worldwide. Infectious Disease Reports, 5(Suppl 1), 15-20. [More Information]
Gordon, J., Wong, J., Rasko, J. (2013). MicroRNAs in myeloid malignancies. British Journal of Haematology, 162(2), 162-176. [More Information]
Wong, J., Ritchie, W., Ebner, O., Selbach, M., Wong, J., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., Thoeng, A., Khoo, T., Bailey, C., Holst, J., Rasko, J. (2013). Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation. Cell, 154(3), 583-595. [More Information]
Taft, R., Simons, C., Nahkuri, S., Oey, H., Korbie, D., Mercer, T., Holst, J., Ritchie, W., Wong, J., Rasko, J., et al (2010). Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans. Nature Structural and Molecular Biology, 17(8), 1030-1035. [More Information]

show 51 more

By Year

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2024

Pinello, N., Song, R., Lee, Q., Calonne, E., Larance, M., Fuks, F., Wong, J. (2024). A multiomics dataset for the study of RNA modifications in human macrophage differentiation and polarisation. Scientific Data, 11(1). [More Information]
Wu, S., Wang, X., Xia, Y., Liu, R., Alexander, S., Wong, J., Zhang, Y., Zheng, X., Feng, Y., Song, R., et al (2024). Foxp1 Is Required for Renal Intercalated Cell Differentiation and Acid-Base Regulation. Journal of the American Society of Nephrology, 35(5), 533-548. [More Information]
Shen, C., Feng, S., Hao, Y., Zhao, A., Kirkby, M., Kurera, M., Zhang, J., Venkataraman, S., Liu, C., Song, R., Wong, J., Schumann, U., et al (2024). Inflammasome protein scaffolds the DNA damage complex during tumor development. Nature Immunology. [More Information]
Pandey, A., Shen, C., Feng, S., Enosi Tuipulotu, D., Ngo, C., Liu, C., Kurera, M., Mathur, A., Venkataraman, S., Zhang, J., Song, R., Wong, J., et al (2024). Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome. Science Advances, 10(4). [More Information]
Wong, A., Wong, J., Rasko, J., Schmitz, U. (2024). SpliceWiz: interactive analysis and visualization of alternative splicing in R. Briefings in Bioinformatics, 25(1), bbad468. [More Information]

show 2 more

2023

Zhang, J., Yang, J., Duval, C., Edin, M., Williams, A., Lei, L., Tu, M., Pourmand, E., Song, R., Graves, J., Wong, J., et al (2023). CYP eicosanoid pathway mediates colon cancer-promoting effects of dietary linoleic acid. The FASEB Journal, 37(7), e23009. [More Information]
Wang, R., Zhao, Q., Liu, R., Zheng, X., Lu, D., Song, R., Du, L., Yang, X., Wu, S., Wang, X., Wong, J., et al (2023). Epicardial CCM2 Promotes Cardiac Development and Repair Via its Regulation on Cytoskeletal Reorganization. JACC: Basic to Translational Science. [More Information]
Hitchins, M., Alvarez, R., Zhou, L., Aguirre, F., Dámaso, E., Pineda, M., Capella, G., Wong, J., Yuan, X., Ryan, S., et al (2023). MLH1-methylated endometrial cancer under 60 years of age as the “sentinel” cancer in female carriers of high-risk constitutional MLH1 epimutation. Gynecologic Oncology, 171, 129-140. [More Information]
Huang, H., Song, R., Wong, J., Anggono, V., Widagdo, J. (2023). The N6-methyladenosine RNA landscape in the aged mouse hippocampus. Aging Cell, 22(1). [More Information]

show 1 more

2022

Song, R., Wong, J. (2022). Altered expression of m1A regulatory genes is associated with oncogenic pathways, overall survival, and infiltration of immune cells in diverse human cancers. Genes & Diseases. [More Information]
Song, R., Tikoo, S., Jain, R., Pinello, N., Au, A., Nagarajah, R., Porse, B., Rasko, J., Wong, J. (2022). Dynamic intron retention modulates gene expression in the monocytic differentiation pathway. Immunology, 165(2), 274-286. [More Information]
Petrova, V., Song, R., Nordström, K., Walter, J., Wong, J., Armstrong, N., Rasko, J., Schmitz, U. (2022). Increased chromatin accessibility facilitates intron retention in specific cell differentiation states. Nucleic Acids Research, 50(20), 11563-11579. [More Information]
Wong, J., Schmitz, U. (2022). Intron retention: importance, challenges, and opportunities. Trends in Genetics, 38(8), 789-792. [More Information]
Zhu, S., Rao, X., Qian, Y., Chen, J., Song, R., Yan, H., Yang, X., Hu, J., Wang, X., Han, Z., Wong, J., McCaughan, G., et al (2022). Liver Endothelial Heg Regulates Vascular/Biliary Network Patterning and Metabolic Zonation Via Wnt Signaling. Cellular and Molecular Gastroenterology and Hepatology, 13(6), 1757-1783. [More Information]
Hortle, E., Tran, V., Wright, K., Fontaine, A., Pinello, N., O'Rourke, M., Wong, J., Hansbro, P., Britton, W., Oehlers, S. (2022). OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection. Life Science Alliance, 5(9), e202201476. [More Information]
Widagdo, J., Wong, J., Anggono, V. (2022). The m6A-epitranscriptome in brain plasticity, learning and memory. Seminars in Cell & Developmental Biology, 125, 110-121. [More Information]
Widagdo, J., Anggono, V., Wong, J. (2022). The multifaceted effects of YTHDC1-mediated nuclear m6A recognition. Trends in Genetics, 38(4), 325-332. [More Information]
Shah, J., Milevskiy, M., Petrova, V., Au, A., Wong, J., Visvader, J., Schmitz, U., Rasko, J. (2022). Towards resolution of the intron retention paradox in breast cancer. Breast Cancer Research, 24(1). [More Information]
Chen, X., Zhou, W., Song, R., Liu, S., Wang, S., Chen, Y., Gao, C., He, C., Xiao, J., Zhang, L., Wong, J., et al (2022). Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity. Science Advances, 8(4), eabl5220. [More Information]

show 7 more

2021

Choi, J., Yang, X., He, S., Song, R., Xu, Z., Foley, M., Wong, J., Xu, C., Zheng, X. (2021). CCM2L (Cerebral Cavernous Malformation 2 Like) Deletion Aggravates Cerebral Cavernous Malformation Through Map3k3-KLF Signaling Pathway. Stroke, 52(4), 1428-1436. [More Information]
Alharbi, A., Schmitz, U., Marshall, A., Vanichkina, D., Nagarajah, R., Vellozzi, M., Wong, J., Bailey, C., Rasko, J. (2021). Ctcf haploinsufficiency mediates intron retention in a tissue-specific manner. RNA Biology, 18(1), 93-103. [More Information]
Wang, R., Wu, S., Yang, X., Qian, Y., Choi, J., Gao, R., Song, S., Wang, Y., Zhuang, T., Wong, J., Alexander, S., et al (2021). Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting. JCI Insight, 6(12), e142838. [More Information]
Green, I., Liu, R., Wong, J. (2021). The expanding role of alternative splicing in vascular smooth muscle cell plasticity. International Journal of Molecular Sciences, 22(19), 10213. [More Information]

show 1 more

2020

Lan, J., Rajan, N., Bizet, M., Penning, A., Singh, N., Guallar, D., Calonne, E., Li Greci, A., Bonvin, E., Deplus, R., Song, R., Wong, J., et al (2020). Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation. Nature Communications, 11(1), 1-15. [More Information]
Li, X., Li, N., Huang, L., Xu, S., Zheng, X., Hamsath, A., Zhang, M., Dai, L., Zhang, H., Wong, J., et al (2020). Is Hydrogen Sulfide a Concern During Treatment of Lung Adenocarcinoma With Ammonium Tetrathiomolybdate? Frontiers in Oncology, 10, 234. [More Information]
Green, I., Pinello, N., Song, R., Lee, Q., Halstead, J., Kwok, C., Wong, A., Nair, S., Clark, S., Roediger, B., Schmitz, U., Larance, M., Rasko, J., Wong, J., et al (2020). Macrophage development and activation involve coordinated intron retention in key inflammatory regulators. Nucleic Acids Research, 48(12), 6513-6529. [More Information]
Lee, Q., Padula, M., Pinello, N., Williams, S., O'Rourke, M., Fumagalli, M., Orkin, J., Song, R., Shaban, B., Brenner, O., Weninger, W., Wong, J., Roediger, B., et al (2020). Murine and related chapparvoviruses are nephro-tropic and produce novel accessory proteins in infected kidneys. PLoS Pathogens, 16(1), e1008262. [More Information]
Schmitz, U., Shah, J., Dhungel, B., Monteuuis, G., Luu, P., Petrova, V., Metierre, C., Nair, S., Bailey, C., Saunders, V., Wong, J., Rasko, J., et al (2020). Widespread aberrant alternative splicing despite molecular remission in chronic myeloid leukaemia patients. Cancers, 12(12), 1-19. [More Information]

show 2 more

2019

Gao, D., Pinello, N., Nguyen, T., Thoeng, A., Nagarajah, R., Holst, J., Rasko, J., Wong, J. (2019). DNA methylation/hydroxymethylation regulate gene expression and alternative splicing during terminal granulopoiesis. Epigenomics, 11(1), 95-109. [More Information]
Monteuuis, G., Wong, J., Bailey, C., Schmitz, U., Rasko, J. (2019). The changing paradigm of intron retention: regulation, ramifications and recipes. Nucleic Acids Research, 47(22), 11497-11513. [More Information]

2018

Pinello, N., Sun, S., Wong, J. (2018). Aberrant expression of enzymes regulating m 6 A mRNA methylation: implication in cancer. Cancer Biology & Medicine, 15(4), 323-334. [More Information]
Roediger, B., Lee, Q., Tikoo, S., Cobbin, J., Henderson, J., Jormakka, M., O'Rourke, M., Padula, M., Pinello, N., Henry, M., Wynne, M., Lisowski, L., Tay, S., Harris, D., Bertolino, P., Wong, J., Gorrell, M., Holmes, E., Jolly, C., Weninger, W., et al (2018). An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis. Cell, 175(2), 530-540. [More Information]
Vanichkina, D., Schmitz, U., Wong, J., Rasko, J. (2018). Challenges in defining the role of intron retention in normal biology and disease. Seminars in Cell and Developmental Biology, 75, 40-49. [More Information]
Cook, S., Lee, Q., Wong, A., Spann, B., Vincent, J., Wong, J., Schlitzer, A., Gorrell, M., Weninger, W., Roediger, B. (2018). Differential chemokine receptor expression and usage by pre-cDC1 and pre-cDC2. Immunology and Cell Biology, 96(10), 1131-1139. [More Information]
Nair, S., Luu, P., Qu, W., Maddugoda, M., Huschtscha, L., Reddel, R., Chenevix-Trench, G., Toso, M., Kench, J., Horvath, L., Hayes, V., Rasko, J., Wong, J., et al (2018). Guidelines for whole genome bisulphite sequencing of intact and FFPET DNA on the Illumina HiSeq X Ten. Epigenetics & Chromatin, 11(1), 1-20. [More Information]
Rajasekhar, M., Schmitz, U., Flamant, S., Wong, J., Bailey, C., Ritchie, W., Holst, J., Rasko, J. (2018). Identifying microRNA determinants of human myelopoiesis. Scientific Reports, 8(1), 1-15. [More Information]
Wong, A., Rasko, J., Wong, J. (2018). We skip to work: alternative splicing in normal and malignant myelopoiesis. Leukemia, 32(5), 1081-1093. [More Information]

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2017

Kwok, C., Marshall, A., Rasko, J., Wong, J. (2017). Genetic alterations of m(6)A regulators predict poorer survival in acute myeloid leukemia. Journal of Hematology and Oncology, 10(1), 39. [More Information]
Schmitz, U., Pinello, N., Jia, F., Alasmari, S., Ritchie, W., Keightley, M., Shini, S., Lieschke, G., Wong, J., Rasko, J. (2017). Intron retention enhances gene regulatory complexity in vertebrates. Genome Biology, 18(1), 1-15. [More Information]
Wong, J., Gao, D., Nguyen, T., Kwok, C., van Geldermalsen, M., Middleton, R., Pinello, N., Thoeng, A., Nagarajah, R., Holst, J., Ritchie, W., Rasko, J. (2017). Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment. Nature Communications, 8, 1-13. [More Information]
Middleton, R., Gao, D., Thomas, A., Singh, B., Au, A., Wong, J., Bomane, A., Cosson, B., Eyras, E., Rasko, J., et al (2017). IRFinder: Assessing the impact of intron retention on mammalian gene expression. Genome Biology, 18(1), 1-11. [More Information]
Rasko, J., Wong, J. (2017). Nuclear microRNAs in normal hemopoiesis and cancer. Journal of Hematology and Oncology, 10(1), 1-8. [More Information]
Tan, M., Widagdo, J., Chau, Y., Zhu, T., Wong, J., Cheung, A., Anggono, V. (2017). The activity-induced long non-coding RNA Meg3 modulates AMPA receptor surface expression in primary cortical neurons. Frontiers in Cellular Neuroscience, 11, 1-12. [More Information]

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2016

Edwards, C., Ritchie, W., Wong, J., Schmitz, U., Middleton, R., An, X., Mohandas, N., Rasko, J., Blobel, G. (2016). A dynamic intron retention program in the mammalian megakaryocyte and erythrocyte lineages. Blood, 127(17), e24-e34. [More Information]
Wong, J., Au, A., Ritchie, W., Rasko, J. (2016). Intron retention in mRNA: No longer nonsense: Known and putative roles of intron retention in normal and disease biology. BioEssays, 38(1), 41-49. [More Information]
Wong, J., Au, A., Gao, D., Pinello, N., Kwok, C., Thoeng, A., Lau, K., Gordon, J., Schmitz, U., Feng, Y., Nguyen, T., Middleton, R., Bailey, C., Holst, J., Rasko, J., Ritchie, W. (2016). RBM3 regulates temperature sensitive miR-142-5p and miR-143 (thermomiRs), which target immune genes and control fever. Nucleic Acids Research, 44(6), 2888-2897. [More Information]

2015

Wang, Q., Hardie, R., Hoy, A., van Geldermalsen, M., Gao, D., Fazli, L., Sadowski, M., Balaban, S., Schreuder, M., Nagarajah, R., Wong, J., Metierre, C., Pinello, N., Otte, N., Bailey, C., Ritchie, W., Rasko, J., Holst, J., et al (2015). Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development. Journal of Pathology, 236(3), 278-289. [More Information]

2014

Wong, J., Lau, K., Pinello, N., Rasko, J. (2014). Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia. Cancer Science, 105(11), 1457-1463. [More Information]
Wong, J., Ritchie, W., Gao, D., Lau, K., Gonzalez, M., Choudhary, A., Taft, R., Rasko, J., Holst, J. (2014). Identification of nuclear-enriched miRNAs during mouse granulopoiesis. Journal of Hematology and Oncology, 7(1), 1-15. [More Information]
Clancy, J., Patel, H., Hussein, S., Tonge, P., Cloonan, N., Corso, A., Li, M., Lee, D., Shin, J., Wong, J., Bailey, C., Rasko, J., et al (2014). Small RNA changes en route to distinct cellular states of induced pluripotency. Nature Communications, 5, 1-9. [More Information]

2013

Lau, K., Wong, J. (2013). Current trends of HIV recombination worldwide. Infectious Disease Reports, 5(Suppl 1), 15-20. [More Information]
Gordon, J., Wong, J., Rasko, J. (2013). MicroRNAs in myeloid malignancies. British Journal of Haematology, 162(2), 162-176. [More Information]
Wong, J., Ritchie, W., Ebner, O., Selbach, M., Wong, J., Huang, Y., Gao, D., Pinello, N., Gonzalez, M., Baidya, K., Thoeng, A., Khoo, T., Bailey, C., Holst, J., Rasko, J. (2013). Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation. Cell, 154(3), 583-595. [More Information]

2010

Taft, R., Simons, C., Nahkuri, S., Oey, H., Korbie, D., Mercer, T., Holst, J., Ritchie, W., Wong, J., Rasko, J., et al (2010). Nuclear-localized tiny RNAs are associated with transcription initiation and splice sites in metazoans. Nature Structural and Molecular Biology, 17(8), 1030-1035. [More Information]

Selected Grants

2023

Senior Lecturer in Cancer, Wong J, Faculty of Medicine and Health/New Academic Staff Funding

2022

Targeting RNA in vascular smooth muscle cells to treat aortic aneurysms, Wong J, Lee Q, Song R, Liu R, Robertson E, Bannon P, Hambly B, Rausch O, NSW Health/Early Mid-Career Researcher Grant

2021

Alternative splicing: A novel target to improve outcomes in acute myeloid leukaemia, Johnstone R, Wong J, Wong A, Rasko J, National Health and Medical Research Council (NHMRC)/Ideas Grant

2020

Deciphering the role of TET2-HDAC4 in the regulation of vascular smooth muscle plasticity, Liu R, Wong J, National Health and Medical Research Council (NHMRC)/Project Grants

2019

Deciphering the role of aberrant RNA modification to improve therapy of acute myeloid leukaemia, Wong J, Tour de Cure Ltd/Mid Career Researcher Grant

2018

The role of altered RNA N6-adenosine m6A methylation in acute myeloid leukaemia, Wong J, Rasko J, Cancer Council NSW/Project Grant
SOAR Fellowship, Wong J, DVC Research/SOAR Fellowships

2017

New Initiatives in Basic and Applied Medical Research, Rasko J, Bailey C, Wong J, Schmitz U, Philip Bushell Foundation/Research Support
Defining the role of aberrant splicing intron retention in the development and maintenance of acute myeloid leukaemia, Wong J, Rasko J, Cancer Institute NSW/Career Development Fellowship

2016

Deciphering the role of DNA methylation in the regulation of alternative splicing, Lister R, Wong J, Rasko J, National Health and Medical Research Council (NHMRC)/Project Grants

2014

Investigating widespread regulation of gene expression through intron retention, Rasko J, Ritchie W, Wong J, National Health and Medical Research Council (NHMRC)/Project Grants

2013

Linking mutations and epigenetic silencing ofsplicing factors to aberrant splicing in acutemyeloid leukaemia, Wong J, Cancer Institute NSW/Early Career Fellowship