Dr Kavitha Kothur

Clinical Lecturer
Children's Hospital at Westmead Clinical School

Member of the Brain and Mind Centre

Telephone 98452657

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Research interests

Dr Kothur is a paediatric neurologist. She completed a PhD in the development of cerebrospinal fluid biomarkers in paediatric neurological disorders. Her research is focussed on genetic testing in refractory epilepsy, functional genomics, improving seizure, social and cognitive outcomes following epilepsy surgery and understanding role of inflammation in epilepsy. She aims to translate reteach into the practice of personalised medicine of epilepsy.

She has key collaborations with A/Prof Bruce Bennett (Molecular genetics laboratory), Sarah McIntyre (CPAlliance), Dr Deepak Gill (Epilepsy), Prof Sunny Lah (Psychosocial outcome), Prof Patrick Kwan (Genomics), and Prof Mary Collins (GABAR functional genomics).

Current projects

Epilepsy in Cerebral Palsy: defining prevalence and risk factors, quality of life, and subgroups of genetic and surgically remediable epilepsy

Clinical utility and cost-effectiveness of genome sequencing for refractory epilepsy in children and adults: a multicentre randomised controlled trial

Associations

Kids Neuroscience Centre, The Sydeny Children's Hospital Network

Selected publications

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Journals

  • Jones, H., Sharma, S., Mohammad, S., Kothur, K., Patel, S., Brilot-Turville, F., Guastella, A., Dale, R., Hofer, M. (2019). Maternal thyroid autoimmunity associated with acute-onset neuropsychiatric disorders and global regression in offspring. Developmental Medicine and Child Neurology, In Press, 1-5. [More Information]
  • Kothur, K., Bandodkar, S., Chu, S., Wienholt, L., Johnson, A., Barclay, P., Brogan, P., Rice, G., Crow, Y., Dale, R. (2018). An open-label trial of JAK 1/2 blockade in progressive IFIH1-associated neuroinflammation. Neurology, 90(6), 289-291. [More Information]
  • Kothur, K., Holman, K., Farnsworth, E., Ho, G., Lorentzos, M., Troedson, C., Gupta, S., Webster, R., Procopis, P., Menezes, M., Ardern-Holmes, S., Dale, R., Gill, D., Bennetts, B., et al (2018). Diagnostic yield of targeted massively parallel sequencing in children with epileptic encephalopathy. Seizure, 59, 132-140. [More Information]
  • Kothur, K., Gill, D., Wong, M., Mohammad, S., Bandodkar, S., Arbunckle, S., Wienholt, L., Dale, R. (2017). Cerebrospinal fluid cyto-/chemokine profile during acute herpes simplex virus induced anti-N-methyl-d-aspartate receptor encephalitis and in chronic neurological sequelae. Developmental Medicine and Child Neurology, 59(8), 806-814. [More Information]
  • Nosadini, M., Mohammad, S., Corazza, F., Ruga, E., Kothur, K., Perilongo, G., Frigo, A., Toldo, I., Dale, R., Sartori, S. (2017). Herpes simplex virus-induced anti-N-methyl-D-aspartate receptor encephalitis: a systematic literature review with analysis of 43 cases. Developmental Medicine and Child Neurology, 59(8), 796-805. [More Information]
  • Kothur, K., Wienholt, L., Tantsis, E., Earl, J., Bandodkar, S., Prelog, K., Tea, F., Ramanathan, S., Brilot-Turville, F., Dale, R. (2016). B Cell, Th17, and Neutrophil Related Cerebrospinal Fluid Cytokine/Chemokines Are Elevated in MOG Antibody Associated Demyelination. PloS One, 11(2), 1-16. [More Information]
  • Kothur, K., Wienholt, L., Brilot, F., Dale, R. (2016). CSF cytokines/chemokines as biomarkers in neuroinflammatory CNS disorders: A systematic review. Cytokine, 77, 227-237. [More Information]
  • Kothur, K., Wienholt, L., Mohammad, S., Tantsis, E., Pillai, S., Britton, P., Jones, C., Angiti, R., Barnes, E., Schlub, T., Brilot-Turville, F., Dale, R., et al (2016). Utility of CSF Cytokine/Chemokines as Markers of Active Intrathecal Inflammation: Comparison of Demyelinating, Anti-NMDAR and Enteroviral Encephalitis. PloS One, 11(8), 1-19. [More Information]
  • Chudleigh, C., Kozlowska, K., Kothur, K., Davies, F., Baxter, H., Landini, A., Hazell, P., Baslet, G. (2013). Managing Non-epileptic Seizures and Psychogenic Dystonia in an Adolescent Girl with Preterm Brain Injury. Harvard Review of Psychiatry, 21(3), 163-174. [More Information]
  • Kothur, K., Kaul, S., Rammurthi, S., Srinivasarao Bandar, V., Suryaprabha, S., Rukmini Mrudula, K. (2012). Use of thrombolytic therapy in cerebral venous sinus thrombosis with ulcerative colitis. Annals of Indian Academy of Neurology, 15(1), 35-38. [More Information]

2019

  • Jones, H., Sharma, S., Mohammad, S., Kothur, K., Patel, S., Brilot-Turville, F., Guastella, A., Dale, R., Hofer, M. (2019). Maternal thyroid autoimmunity associated with acute-onset neuropsychiatric disorders and global regression in offspring. Developmental Medicine and Child Neurology, In Press, 1-5. [More Information]

2018

  • Kothur, K., Bandodkar, S., Chu, S., Wienholt, L., Johnson, A., Barclay, P., Brogan, P., Rice, G., Crow, Y., Dale, R. (2018). An open-label trial of JAK 1/2 blockade in progressive IFIH1-associated neuroinflammation. Neurology, 90(6), 289-291. [More Information]
  • Kothur, K., Holman, K., Farnsworth, E., Ho, G., Lorentzos, M., Troedson, C., Gupta, S., Webster, R., Procopis, P., Menezes, M., Ardern-Holmes, S., Dale, R., Gill, D., Bennetts, B., et al (2018). Diagnostic yield of targeted massively parallel sequencing in children with epileptic encephalopathy. Seizure, 59, 132-140. [More Information]

2017

  • Kothur, K., Gill, D., Wong, M., Mohammad, S., Bandodkar, S., Arbunckle, S., Wienholt, L., Dale, R. (2017). Cerebrospinal fluid cyto-/chemokine profile during acute herpes simplex virus induced anti-N-methyl-d-aspartate receptor encephalitis and in chronic neurological sequelae. Developmental Medicine and Child Neurology, 59(8), 806-814. [More Information]
  • Nosadini, M., Mohammad, S., Corazza, F., Ruga, E., Kothur, K., Perilongo, G., Frigo, A., Toldo, I., Dale, R., Sartori, S. (2017). Herpes simplex virus-induced anti-N-methyl-D-aspartate receptor encephalitis: a systematic literature review with analysis of 43 cases. Developmental Medicine and Child Neurology, 59(8), 796-805. [More Information]

2016

  • Kothur, K., Wienholt, L., Tantsis, E., Earl, J., Bandodkar, S., Prelog, K., Tea, F., Ramanathan, S., Brilot-Turville, F., Dale, R. (2016). B Cell, Th17, and Neutrophil Related Cerebrospinal Fluid Cytokine/Chemokines Are Elevated in MOG Antibody Associated Demyelination. PloS One, 11(2), 1-16. [More Information]
  • Kothur, K., Wienholt, L., Brilot, F., Dale, R. (2016). CSF cytokines/chemokines as biomarkers in neuroinflammatory CNS disorders: A systematic review. Cytokine, 77, 227-237. [More Information]
  • Kothur, K., Wienholt, L., Mohammad, S., Tantsis, E., Pillai, S., Britton, P., Jones, C., Angiti, R., Barnes, E., Schlub, T., Brilot-Turville, F., Dale, R., et al (2016). Utility of CSF Cytokine/Chemokines as Markers of Active Intrathecal Inflammation: Comparison of Demyelinating, Anti-NMDAR and Enteroviral Encephalitis. PloS One, 11(8), 1-19. [More Information]

2013

  • Chudleigh, C., Kozlowska, K., Kothur, K., Davies, F., Baxter, H., Landini, A., Hazell, P., Baslet, G. (2013). Managing Non-epileptic Seizures and Psychogenic Dystonia in an Adolescent Girl with Preterm Brain Injury. Harvard Review of Psychiatry, 21(3), 163-174. [More Information]

2012

  • Kothur, K., Kaul, S., Rammurthi, S., Srinivasarao Bandar, V., Suryaprabha, S., Rukmini Mrudula, K. (2012). Use of thrombolytic therapy in cerebral venous sinus thrombosis with ulcerative colitis. Annals of Indian Academy of Neurology, 15(1), 35-38. [More Information]

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