Dr Min Hu

NHMRC Training Fellow
Westmead Millennium Institute for Medical Research, Westmead Clinical School

Telephone +61 2 98453106
Fax 98453078

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Selected grants

2013

  • Building sustainable collaborations in diabetes and islet transplantation research and practice in Sydney and Shanghai; Hu M, Alexander S, Freckelton L, Hawthorne W, O'Connell P, Wang W, Ning G, Li X, Gu W, Dai J; DVC International/IPDF Grant.

2012

  • XXIV International Congress of The Transplantation Society (TTS) 2012, Berlin, Germany.; Hu M; Juvenile Diabetes Research Foundation/Research Support.

2011

  • Induction of Islet Transplant Tolerance in a Humanised Mouse Model; Hu M; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Journals

  • Jin, X., Wang, Y., Hawthorne, W., Hu, M., Yi, S., O'Connell, P. (2014). Enhanced Suppression of the Xenogeneic T-Cell Response in Vitro by Xenoantigen Stimulated and Expanded Regulatory T Cells. Transplantation, 97(1), 30-38. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Tan, T., Lee, S., Zhang, J., Zhang, G., Hu, M., Wang, C., Cao, Q., Zhao, Y., Harris, D., et al (2014). Regulatory T cells require renal antigen recognition through the TCR to protect against injury in nephritis. International Journal of Clinical and Experimental Pathology, 7(1), 38-47.
  • Hu, M., Fletcher, J., McCahon, E., Catchpoole, D., Zhang, G., Wang, Y., Algar, E., Alexander, S. (2013). Bilateral Wilms Tumor and Early Presentation in Pediatric Patients Is Associated with the Truncation of the Wilms Tumor 1 Protein. The Journal of Pediatrics, 163(1), 224-229. [More Information]
  • Wang, Y., Zhou, J., Wang, Y., Watson, D., Zhang, G., Hu, M., Wu, H., Zheng, G., Wang, Y., Durkan, A., Harris, D., Alexander, S. (2013). Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease. International Journal of Clinical and Experimental Pathology, 6(3), 326-333. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Zhang, G., Zhou, J., Tan, T., Cao, Q., Hu, M., Watson, D., Wu, H., Zheng, D., Wang, C., Harris, D., et al (2013). DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. Kidney International, 83(2), 223-232. [More Information]
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation, 13, 2819-2830. [More Information]
  • Hu, M., Wu, J., Zhang, G., Wang, Y., Watson, D., Yi, S., Hawthorne, W., O'Connell, P., Alexander, S. (2013). Selective Depletion of Alloreactive T cells Leads to Long-Term Islet Allograft Survival Across a Major Histocompatibility Complex Mismatch in Diabetic Mice. Cell Transplantation, 22(10), 1929-1941. [More Information]
  • Wang, Y., Zhang, G., Hu, M., Polhill, T., Sawyer, A., Zhou, J., Saito, M., Watson, D., Wu, H., Wang, Y., Wang, X., Wang, Y., Harris, D., Alexander, S. (2012). CD8+ Regulatory T Cells Induced by T Cell Vaccination Protect Against Autoimmune Nephritis. Journal of the American Society of Nephrology, 23(6), 1058-1067. [More Information]
  • Zhou, J., Wang, Y., Lee, V., Phoon, R., Zhang, G., Wang, Y., Tan, T., Hu, M., Wang, D., Saito, M., Harris, D., Durkan, A., et al (2012). DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration. International Journal of Clinical and Experimental Medicine, 5(1), 24-33. [More Information]
  • Polhill, T., Zhang, G., Hu, M., Sawyer, A., Zhou, J., Saito, M., Webster, K., Wang, Y., Wang, Y., Grey, S., Harris, D., Alexander, S., Wang, Y., et al (2012). IL-2/IL-2Ab Complexes Induce Regulatory T Cell Expansion and Protect against Proteinuric CKD. Journal of the American Society of Nephrology, 23(8), 1303-1308. [More Information]
  • Wang, Y., McRae, J., Robson, S., Cowan, P., Zhang, G., Hu, M., Polhill, T., Wang, Y., Zheng, G., Wang, Y., Lee, V., Harris, D., Alexander, S., et al (2012). Regulatory T cells participate in CD39-mediated protection from renal injury. European Journal of Immunology, 42(9), 2441-2451. [More Information]
  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, A. (2011). Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant Immunology, 24(3), 149-156. [More Information]
  • Ginn, S., Liao, S., Dane, A., Hu, M., Hyman, J., Finnie, J., Zheng, M., Cavazzana-Calvo, M., Alexander, S., Thrasher, A., Alexander, I. (2010). Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and gammac Overexpression. Molecular Therapy, 18(5), 965-976. [More Information]
  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009). Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American Journal of Pathology: cellular and molecular biology of disease, 175(2), 580-591. [More Information]
  • Zhang, G., Hu, M., Wang, Y., Alexander, S. (2009). FOXP3 as a marker of tolerance induction versus rejection. Current Opinion in Organ Transplantation, 14(1), 40-45. [More Information]
  • Watson, D., Hu, M., Zhang, G., Wang, Y., Alexander, S. (2009). Tolerance induction by removal of alloreactive T cells: in-vivo and pruning strategies. Current Opinion in Organ Transplantation, 14(4), 357-363. [More Information]
  • Alexander, S., Smith, N., Hu, M., Verran, D., Shun, A., Dorney, S., Smith, A., Webster, B., Shaw, P., Lammi, A., Stormon, M. (2008). Chimerism and Tolerance in a Recipient of a Deceased-Donor Liver Transplant. New England Journal of Medicine, 358(4), 369-374. [More Information]
  • Hu, M., Watson, D., Zhang, G., Graf, N., Wang, Y., Sartor, M., Howden, B., Fletcher, J., Alexander, S. (2008). Long-term cardiac allograft survival across an MHC mismatch after "pruning" of alloreactive CD4 T cells. Journal of Immunology, 180(10), 6593-6603. [More Information]
  • Wang, Y., Hu, M., Wang, Y., Polhill, T., Zhang, G., Wang, Y., Lee, V., Harris, D., Alexander, S. (2008). Regulatory T Cells in Renal Disease. International Journal of Clinical and Experimental Medicine, 1(4), 294-304. [More Information]
  • Wu, H., Wang, Y., Wang, Y., Hu, M., Zhang, G., Knight, J., Harris, D., Alexander, S. (2007). Depletion of γδ T Cells Exacerbates Murine Adriamycin Nephropathy. Journal of the American Society of Nephrology, 18(4), 1180-1189. [More Information]
  • Hu, M., Kramer, B., Zhang, G., McCowage, G., Alexander, I., Gunning, P., Alexander, S. (2006). Long term skin allograft survival in mice with MGMT chimeric bone marrow engraftment. Immunology and Cell Biology, 84 (Suppl.)(3), A29-A29.
  • Hu, M., Wang, C., Cordoba, S., Zhang, G., Wang, Y., Watson, D., Bishop, A., Alexander, S. (2005). Foxp3 expression correlates with tolerance in a mouse allograft model of cardiac rejection and renal tolerance. Immunology and Cell Biology, 83(4), A21-A21.
  • Fletcher, J., Hu, M., Berman, Y., Collins, F., Grigg, J., McIver, M., Juppner, H., Alexander, S. (2005). Multicystic dysplastic kidney and variable phenotype in a family with a novel deletion mutation of PAX2. Journal of the American Society of Nephrology, 16(9), 2754-2761. [More Information]
  • Hu, M., Craig, J., Howard, N., Kan, A., Chaitow, J., Little, D., Alexander, S. (2004). A Novel Mutation Of WT1 Exon 9 In A Patient With Denys-Drash Syndrome And Pyloric Stenosis. Pediatric Nephrology, 19(10), 1160-1163. [More Information]
  • Foster, A., Marangolo, M., Sartor, M., Alexander, S., Hu, M., Bradstock, K., Gottlieb, D. (2004). Human Cd62L- Memory T Cells Are Less Responsive To Alloantigen Stimulation Than Cd62L+ Naive T Cells: Potential For Adoptive Immunotherapy And Allodepletion. Blood, 104(8), 2403-2409.
  • Hu, M., Zhang, G., Walters, G., Sartor, M., Watson, D., Knight, J., Alexander, S. (2004). Matching T-Cell Receptors Identified In Renal Biopsies And Urine At The Time Of Acute Rejection In Pediatric Renal Transplant Patients. American Journal Of Transplantation, 4(11), 1859-1868.
  • Hu, M., Zhang, G., Arbuckle, S., Graf, N., Shun, A., Silink, M., Lewis, D., Alexander, S. (2004). Prophylactic Bilateral Nephrectomies In Two Paediatric Patients With Missense Mutations In The Wt1 Gene. Nephrology, Dialysis, Transplantation, 19(1), 223-226.

Conferences

  • Hu, M., Kramer, B., Zhang, G., McCowage, G., Alexander, I., Gunning, P., Alexander, S. (2006). Long term skin allograft survival in mice with MGMT chimeric bone marrow engraftment. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Wang, Y., Zhang, G., Wang, Y., Hu, M., Wu, H., Watson, D., Harris, D., Alexander, S. (2006). T cell vaccination protects against active Heymann nephritis: A CD8 T cell mechanism. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Zhang, G., Hu, M., Wang, Y., Osvath, S., Sedger, L., Alexander, S. (2005). IL-15 required for DST induced tolerance across a major class I mismatch. 6th American Transplant Congress, Oxford, UK: Blackwell Publishing Professionals.

2014

  • Jin, X., Wang, Y., Hawthorne, W., Hu, M., Yi, S., O'Connell, P. (2014). Enhanced Suppression of the Xenogeneic T-Cell Response in Vitro by Xenoantigen Stimulated and Expanded Regulatory T Cells. Transplantation, 97(1), 30-38. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Tan, T., Lee, S., Zhang, J., Zhang, G., Hu, M., Wang, C., Cao, Q., Zhao, Y., Harris, D., et al (2014). Regulatory T cells require renal antigen recognition through the TCR to protect against injury in nephritis. International Journal of Clinical and Experimental Pathology, 7(1), 38-47.

2013

  • Hu, M., Fletcher, J., McCahon, E., Catchpoole, D., Zhang, G., Wang, Y., Algar, E., Alexander, S. (2013). Bilateral Wilms Tumor and Early Presentation in Pediatric Patients Is Associated with the Truncation of the Wilms Tumor 1 Protein. The Journal of Pediatrics, 163(1), 224-229. [More Information]
  • Wang, Y., Zhou, J., Wang, Y., Watson, D., Zhang, G., Hu, M., Wu, H., Zheng, G., Wang, Y., Durkan, A., Harris, D., Alexander, S. (2013). Daedalic DNA vaccination against self antigens as a treatment for chronic kidney disease. International Journal of Clinical and Experimental Pathology, 6(3), 326-333. [More Information]
  • Wang, Y., Wang, Y., Wang, Y., Zheng, G., Zhang, G., Zhou, J., Tan, T., Cao, Q., Hu, M., Watson, D., Wu, H., Zheng, D., Wang, C., Harris, D., et al (2013). DNA vaccine encoding CD40 targeted to dendritic cells in situ prevents the development of Heymann nephritis in rats. Kidney International, 83(2), 223-232. [More Information]
  • Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation, 13, 2819-2830. [More Information]
  • Hu, M., Wu, J., Zhang, G., Wang, Y., Watson, D., Yi, S., Hawthorne, W., O'Connell, P., Alexander, S. (2013). Selective Depletion of Alloreactive T cells Leads to Long-Term Islet Allograft Survival Across a Major Histocompatibility Complex Mismatch in Diabetic Mice. Cell Transplantation, 22(10), 1929-1941. [More Information]

2012

  • Wang, Y., Zhang, G., Hu, M., Polhill, T., Sawyer, A., Zhou, J., Saito, M., Watson, D., Wu, H., Wang, Y., Wang, X., Wang, Y., Harris, D., Alexander, S. (2012). CD8+ Regulatory T Cells Induced by T Cell Vaccination Protect Against Autoimmune Nephritis. Journal of the American Society of Nephrology, 23(6), 1058-1067. [More Information]
  • Zhou, J., Wang, Y., Lee, V., Phoon, R., Zhang, G., Wang, Y., Tan, T., Hu, M., Wang, D., Saito, M., Harris, D., Durkan, A., et al (2012). DEC205-DC targeted DNA vaccines to CX3CR1 and CCL2 are potent and limit macrophage migration. International Journal of Clinical and Experimental Medicine, 5(1), 24-33. [More Information]
  • Polhill, T., Zhang, G., Hu, M., Sawyer, A., Zhou, J., Saito, M., Webster, K., Wang, Y., Wang, Y., Grey, S., Harris, D., Alexander, S., Wang, Y., et al (2012). IL-2/IL-2Ab Complexes Induce Regulatory T Cell Expansion and Protect against Proteinuric CKD. Journal of the American Society of Nephrology, 23(8), 1303-1308. [More Information]
  • Wang, Y., McRae, J., Robson, S., Cowan, P., Zhang, G., Hu, M., Polhill, T., Wang, Y., Zheng, G., Wang, Y., Lee, V., Harris, D., Alexander, S., et al (2012). Regulatory T cells participate in CD39-mediated protection from renal injury. European Journal of Immunology, 42(9), 2441-2451. [More Information]

2011

  • Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, A. (2011). Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant Immunology, 24(3), 149-156. [More Information]

2010

  • Ginn, S., Liao, S., Dane, A., Hu, M., Hyman, J., Finnie, J., Zheng, M., Cavazzana-Calvo, M., Alexander, S., Thrasher, A., Alexander, I. (2010). Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and gammac Overexpression. Molecular Therapy, 18(5), 965-976. [More Information]

2009

  • Zheng, G., Lyons, J., Tan, T., Wang, Y., Hsu, T., Min, D., Succar, L., Rangan, G., Hu, M., Henderson, B., Alexander, S., Harris, D. (2009). Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-{beta}1 in Renal Tubular Epithelial Cells. The American Journal of Pathology: cellular and molecular biology of disease, 175(2), 580-591. [More Information]
  • Zhang, G., Hu, M., Wang, Y., Alexander, S. (2009). FOXP3 as a marker of tolerance induction versus rejection. Current Opinion in Organ Transplantation, 14(1), 40-45. [More Information]
  • Watson, D., Hu, M., Zhang, G., Wang, Y., Alexander, S. (2009). Tolerance induction by removal of alloreactive T cells: in-vivo and pruning strategies. Current Opinion in Organ Transplantation, 14(4), 357-363. [More Information]

2008

  • Alexander, S., Smith, N., Hu, M., Verran, D., Shun, A., Dorney, S., Smith, A., Webster, B., Shaw, P., Lammi, A., Stormon, M. (2008). Chimerism and Tolerance in a Recipient of a Deceased-Donor Liver Transplant. New England Journal of Medicine, 358(4), 369-374. [More Information]
  • Hu, M., Watson, D., Zhang, G., Graf, N., Wang, Y., Sartor, M., Howden, B., Fletcher, J., Alexander, S. (2008). Long-term cardiac allograft survival across an MHC mismatch after "pruning" of alloreactive CD4 T cells. Journal of Immunology, 180(10), 6593-6603. [More Information]
  • Wang, Y., Hu, M., Wang, Y., Polhill, T., Zhang, G., Wang, Y., Lee, V., Harris, D., Alexander, S. (2008). Regulatory T Cells in Renal Disease. International Journal of Clinical and Experimental Medicine, 1(4), 294-304. [More Information]

2007

  • Wu, H., Wang, Y., Wang, Y., Hu, M., Zhang, G., Knight, J., Harris, D., Alexander, S. (2007). Depletion of γδ T Cells Exacerbates Murine Adriamycin Nephropathy. Journal of the American Society of Nephrology, 18(4), 1180-1189. [More Information]

2006

  • Hu, M., Kramer, B., Zhang, G., McCowage, G., Alexander, I., Gunning, P., Alexander, S. (2006). Long term skin allograft survival in mice with MGMT chimeric bone marrow engraftment. Immunology and Cell Biology, 84 (Suppl.)(3), A29-A29.
  • Hu, M., Kramer, B., Zhang, G., McCowage, G., Alexander, I., Gunning, P., Alexander, S. (2006). Long term skin allograft survival in mice with MGMT chimeric bone marrow engraftment. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.
  • Wang, Y., Zhang, G., Wang, Y., Hu, M., Wu, H., Watson, D., Harris, D., Alexander, S. (2006). T cell vaccination protects against active Heymann nephritis: A CD8 T cell mechanism. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006), Australia: Nature Publishing Group.

2005

  • Hu, M., Wang, C., Cordoba, S., Zhang, G., Wang, Y., Watson, D., Bishop, A., Alexander, S. (2005). Foxp3 expression correlates with tolerance in a mouse allograft model of cardiac rejection and renal tolerance. Immunology and Cell Biology, 83(4), A21-A21.
  • Zhang, G., Hu, M., Wang, Y., Osvath, S., Sedger, L., Alexander, S. (2005). IL-15 required for DST induced tolerance across a major class I mismatch. 6th American Transplant Congress, Oxford, UK: Blackwell Publishing Professionals.
  • Fletcher, J., Hu, M., Berman, Y., Collins, F., Grigg, J., McIver, M., Juppner, H., Alexander, S. (2005). Multicystic dysplastic kidney and variable phenotype in a family with a novel deletion mutation of PAX2. Journal of the American Society of Nephrology, 16(9), 2754-2761. [More Information]

2004

  • Hu, M., Craig, J., Howard, N., Kan, A., Chaitow, J., Little, D., Alexander, S. (2004). A Novel Mutation Of WT1 Exon 9 In A Patient With Denys-Drash Syndrome And Pyloric Stenosis. Pediatric Nephrology, 19(10), 1160-1163. [More Information]
  • Foster, A., Marangolo, M., Sartor, M., Alexander, S., Hu, M., Bradstock, K., Gottlieb, D. (2004). Human Cd62L- Memory T Cells Are Less Responsive To Alloantigen Stimulation Than Cd62L+ Naive T Cells: Potential For Adoptive Immunotherapy And Allodepletion. Blood, 104(8), 2403-2409.
  • Hu, M., Zhang, G., Walters, G., Sartor, M., Watson, D., Knight, J., Alexander, S. (2004). Matching T-Cell Receptors Identified In Renal Biopsies And Urine At The Time Of Acute Rejection In Pediatric Renal Transplant Patients. American Journal Of Transplantation, 4(11), 1859-1868.
  • Hu, M., Zhang, G., Arbuckle, S., Graf, N., Shun, A., Silink, M., Lewis, D., Alexander, S. (2004). Prophylactic Bilateral Nephrectomies In Two Paediatric Patients With Missense Mutations In The Wt1 Gene. Nephrology, Dialysis, Transplantation, 19(1), 223-226.

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