Professor Nicholas Buckley

Professor of Clinical Pharmacology
Pharmacology, School of Medical Sciences


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Biographical details

MD FRACP

Professor of Clinical Pharmacology, University of Sydney

Visiting Professor, University of Peradeniya, Sri Lanka & Research Director, South Asian Clinical Toxicology Research Collaboration (SACTRC)

Consultant Clinical Pharmacologist & Toxicologist, NSW Poisons Information Centre & Royal PrinceAlfred Hospital.

Member of Editorial boards of TOXINZ & Hypertox (electronic databases of poisoning information), and the journals Drug Safety, & Clinical Toxicology.

Chair of the Editorial Advisory Board of the Australian Medicines Handbook

Member of the Australian Advisory Committee on the Safety of Medicines (ACSOM)

President–Elect of the Asia Pacific Association of Medical Toxicology.

Research interests

  • Mechanisms and outcomes from acute kidney injury after poisoning/snakebite
  • Effect of pesticide bans and safe storage of pesticides
  • Descriptive studies of the mechanism of toxicity of a range of pesticide poisonings
  • Comparisons of the relative toxicity of different pesticides
  • Measurement of long-term neurotoxicity after acute poisoning
  • Trials of regulatory restrictions and reformulation of pesticides
  • Evaluation of investigations used in poisoning
  • Clinical trials of existing antidotes for poisoning
  • Development of new antidotes for poisoning
  • Clinical trials comparing different strategies to manage snakebite
  • Systematic reviews of treatments of poisoning
  • Developmenttal toxicity from pesticides
  • Paracetamol poisoning
  • Pharmacometrics - modelling of drug concentrations and effects.
  • Cardiotoxicity of psychotropic drugs
  • Toxicovigilance - detection of emerging toxicological problems
  • Epidemiology of poisoning and drug abuse
  • Coronial data on lethal poisoning and adverse drug effects
  • Pharmaco-epidemiology studies on adverse drug effects and drug interactions

Teaching and supervision

My particular interests within undergraduate teaching are problem-based learning, evidence-based clinical teaching and computer-assisted learning (CAL) with a focus on clinical pharmacology and toxicology and understanding the immediate relevance of mechanisms to clinical practice.

International links

Sri Lanka

(South Asian Clinical Toxicology Research Collaboration, University of Peradeniya, Sri Lanka) Research Director

Selected grants

2014

  • Neuromuscular toxicity after pesticides and snakebite; Buckley N, Senanayake N, de Silva H, Karalliedde L; National Health and Medical Research Council (NHMRC)/Project Grants.

Selected publications

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Journals

  • Rajapakse, B., Neeman, T., Buckley, N. (2014). Effect of acetylcholinesterase (AChE) point-of-care testing in OP poisoning on knowledge, attitudes and practices of treating physicians in Sri Lanka. BMC Health Services Research, 14(1), 1-24. [More Information]
  • Wunnapuk, K., Liu, X., Gobe, G., Endre, Z., Peake, P., Grice, J., Roberts, M., Buckley, N. (2014). Kidney biomarkers in MCPA-induced acute kidney injury in rats: Reduced clearance enhances early biomarker performance. Toxicology Letters, 225(3), 467-478. [More Information]
  • Buckley, N., Dawson, A., Isbister, G. (2014). Serotonin syndrome. BMJ, 348, 1-4. [More Information]
  • Pearson, M., Zwi, A., Rouse, A., Fernando, R., Buckley, N., McDuie-Ra, D. (2014). Taking stock - what is known about suicide in Sri Lanka. Crisis-the Journal of Crisis Intervention and Suicide Prevention, 35(2), 390-101. [More Information]
  • Wunnapuk, K., Gobe, G., Endre, Z., Peake, P., Grice, J., Roberts, M., Buckley, N., Liu, X. (2014). Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers. Toxicology Letters, 225(1), 192-200. [More Information]
  • Isbister, G., Buckley, N., Page, C., Scorgie, F., Lincz, L., Seldon, M., Brown, S. (2013). A randomized controlled trial of fresh frozen plasma for treating venom-induced consumption coagulopathy in cases of Australian snakebite (ASP-18). Journal of Thrombosis and Haemostasis, 11(7), 1310-1318. [More Information]
  • Roberts, D., Hall, M., Falkland, M., Strasser, S., Buckley, N. (2013). Amanita phalloides poisoning and treatment with silibinin in the Australian Capital Territory and New South Wales. Medical Journal of Australia, 198(1), 43-47. [More Information]
  • Buckley, N., Juurlink, D. (2013). Carbon monoxide treatment guidelines must acknowledge the limitations of the existing evidence. American Journal of Respiratory and Critical Care Medicine, 187(12), 1390-1390.
  • Brown, J., Buckley, N. (2013). Carbon monoxide-induced death and toxicity from charcoal briquettes. Comment. Medical Journal of Australia, 198(2), 86-86. [More Information]
  • Isbister, G., Maduwage, K., Shahmy, S., Mohamed, F., Abeysinghe, C., Karunathilake, H., Ariaratnam, C., Buckley, N. (2013). Diagnostic 20-min whole blood clotting test in Russell's viper envenoming delays antivenom administration. QJM: Quarterly Journal of Medicine, 106(10), 925-932. [More Information]
  • Senarathna, L., Buckley, N., Dibley, M., Kelly, P., Jayamanna, S., Gawarammana, I., Dawson, A. (2013). Effect of a Brief Outreach Educational Intervention on the Translation of Acute Poisoning Treatment Guidelines to Practice in Rural Sri Lankan Hospitals: A Cluster Randomized Controlled Trial. PLoS One, 8(8), 1-10. [More Information]
  • Konickx, L., Worek, F., Jayamanne, S., Thiermann, H., Buckley, N., Eddleston, M. (2013). Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides. Toxicological Sciences, 136(2), 274-283. [More Information]
  • Wunnapuk, K., Liu, X., Peake, P., Gobe, G., Endre, Z., Grice, J., Roberts, M., Buckley, N. (2013). Renal biomarkers predict nephrotoxicity after paraquat. Toxicology Letters, 222(3), 280-288. [More Information]
  • Isbister, G., Brown, S., Page, C., McCoubrie, D., Greene, S., Buckley, N. (2013). Snakebite in Australia: a practical approach to diagnosis and treatment. Medical Journal of Australia, 199(11), 763-768. [More Information]
  • Buckley, N., Dawson, A. (2013). The intralipid genie is out of the bottle-spin and wishful thinking. Anaesthesia and Intensive Care, 41(2), 154-156. [More Information]
  • Isbister, G., Buckley, N., Brown, S. (2013). Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13). Medical Journal of Australia, 198(4), 194-195. [More Information]
  • Brown, J., Buckley, N. (2013). Toxicity from bodybuilding supplements and recreational use of products containing 1,3-dimethylamylamine. Medical Journal of Australia, 198(8), 414-415. [More Information]
  • Buckley, N., Faunce, T. (2013). Trials and tribulations in the removal of dextropropoxyphene from the Australian Register of Therapeutic Goods. Medical Journal of Australia, 199(4), 257-260. [More Information]
  • Senarathna, L., Jayamanna, S., Kelly, P., Buckley, N., Dibley, M., Dawson, A. (2012). Changing epidemiologic patterns of deliberate self poisoning in a rural district of Sri Lanka. BMC Public Health, 12, 1-8. [More Information]
  • Allen, G., Brown, S., Buckley, N., O'Leary, M., Page, C., Currie, B., White, J., Isbister, G., et al (2012). Clinical effects and antivenom dosing in brown snake (Pseudonaja spp.) envenoming--Australian snakebite project (ASP-14). PLoS One, 7(12), e53188. [More Information]
  • Stavrou, E., Buckley, N., Olivier, J., Pearson, S. (2012). Discontinuation of statin therapy in older people: does a cancer diagnosis make a difference? An observational cohort study using data linkage. BMJ Open, 2(3), 1-6. [More Information]
  • Eddleston, M., Adhikari, S., Egodage, S., Ranganath, H., Mohamed, F., Manuweera, G., Azher, S., Jayamanne, S., Juzczak, E., Sheriff, M., Dawson, A., et al (2012). Effects of a provincial ban of two toxic organophosphorus insecticides on pesticide poisoning hospital admissions. Clinical Toxicology, 50(3), 202-209. [More Information]
  • Jayasinghe, S., Pathirana, K., Buckley, N. (2012). Effects of acute organophosphorus poisoning on function of peripheral nerves: a cohort study. PLoS One, 7(11), e49405. [More Information]
  • Jayawardene, P., Senanayake, N., Buckley, N., Dawson, A. (2012). Electrophysiological correlates of respiratory failure in acute organophosphate poisoning: Evidence for differential roles of muscarinic and nicotinic stimulation. Clinical Toxicology, 50(4), 250-253. [More Information]
  • Stavrou, E., Lu, C., Buckley, N., Pearson, S. (2012). The role of comorbidities on the uptake of systemic treatment and 3-year survival in older cancer patients. Annals of Oncology, 23(9), 2422-2428. [More Information]
  • Senarathna, L., Buckley, N., Jayamanna, S., Kelly, P., Dibley, M., Dawson, A. (2012). Validity of referral hospitals for the toxicovigilance of acute poisoning in Sri Lanka. Bulletin of the World Health Organization, 90(6), 436-443A. [More Information]
  • Pearson, M., Konradsen, F., Gunnell, D., Dawson, A., Pieris, R., Weerasinghe, M., Knipe, D., Jayamanne, S., Metcalfe, C., Hawton, K., et al (2011). A community-based cluster randomised trial of safe storage to reduce pesticide self-poisoning in rural Sri Lanka: study protocol. BMC Public Health, 11(Article no. 879), 879-1-879-8. [More Information]
  • Buckley, N., Rossi, S. (2011). Bringing greater transparency to "black box" warnings. Clinical Toxicology, 49(6), 448-451. [More Information]
  • Roberts, D., Wilks, M., Roberts, M., Swaminathan, R., Mohamed, F., Dawson, A., Buckley, N. (2011). Changes in the concentrations of creatinine, cystatin C and NGAL in patients with acute paraquat self-poisoning. Toxicology Letters, 202(1), 69-74. [More Information]
  • Williams, S., Wijesinghe, C., Jayamanne, S., Buckley, N., Dawson, A., Lalloo, D., de Silva, H. (2011). Delayed psychological morbidity associated with snakebite envenoming. PLoS Neglected Tropical Diseases, 5(8), e1255-e1255. [More Information]
  • Roberts, D., Buckley, N. (2011). Enhanced elimination in acute barbiturate poisoning - a systematic review. Clinical Toxicology, 49(1), 2-12. [More Information]
  • Rajapakse, B., Thiermann, H., Eyer, P., Worek, F., Bowe, S., Dawson, A., Buckley, N. (2011). Evaluation of the Test-mate ChE (Cholinesterase) Field Kit in Acute Organophosphorus Poisoning. Annals of Emergency Medicine, 58(6), 559-564. [More Information]
  • Wilks, M., Tomenson, J., Fernando, R., Ariyananda, R., Berry, D., Buckley, N., Gawarammana, I., Jayamanne, S., Gunnell, D., Dawson, A. (2011). Formulation changes and time trends in outcome following paraquat ingestion in Sri Lanka. Clinical Toxicology. [More Information]
  • Buckley, N., Juurlink, D., Isbister, G., Bennett, M., Lavonas, E. (2011). Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database of Systematic Reviews, 4, CD002041. [More Information]
  • Gawarammana, I., Buckley, N. (2011). Medical management of paraquat ingestion. British Journal of Clinical Pharmacology, 72(5), 745-757. [More Information]
  • Buckley, N., Eddleston, M., Li, Y., Bevan, M., Robertson, J. (2011). Oximes for acute organophosphate pesticide poisoning. Cochrane Database of Systematic Reviews, 2, CD005085. [More Information]
  • Wunnapuk, K., Medley, G., Liu, X., Grice, J., Jayasinghe, S., Gawarammana, I., Buckley, N., Roberts, M. (2011). Simple and sensitive liquid chromatography-tandem mass spectrometry methods for quantification of paraquat in plasma and urine: application to experimental and clinical toxicological studies. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 879(28), 3047-3052. [More Information]
  • Roberts, D., Dawson, A., Senarathna, L., Mohamed, F., Cheng, R., Eaglesham, G., Buckley, N. (2011). Toxicokinetics, including saturable protein binding, of 4-chloro-2-methyl phenoxyacetic acid (MCPA) in patients with acute poisoning. Toxicology Letters, 201(3), 270-276. [More Information]
  • Dawson, A., Buckley, N. (2011). Toxicologists in public health--Following the path of Louis Roche (based on the Louis Roche lecture "An accidental toxicologist in public health", Bordeaux, 2010). Clinical Toxicology, 49(2), 94-101. [More Information]
  • Roberts, D., Buckley, N., Mohamed, F., Eddleston, M., Goldstein, D., Mehrsheikh, A., Bleeke, M., Dawson, A. (2010). A prospective observational study of the clinical toxicology of glyphosate-containing herbicides in adults with acute self-poisoning. Clinical Toxicology, 48(2), 129-136. [More Information]
  • Shihana, F., Dissanayake, D., Buckley, N., Dawson, A. (2010). A simple quantitative bedside test to determine methemoglobin. Annals of Emergency Medicine, 55(2), 184-185. [More Information]
  • Dawson, A., Eddleston, M., Senarathna, L., Mohamed, F., Gawarammana, I., Bowe, S., Manuweera, G., Buckley, N. (2010). Acute human lethal toxicity of agricultural pesticides: a prospective cohort study. PLoS Medicine, 7(10), e1000357. [More Information]
  • Ireland, G., Brown, S., Buckley, N., Stormer, J., Curie, B., White, J., Spain, D., Isbister, G. (2010). Changes in serial laboratory test results in snakebite patients: when can we safely exclude envenoming? Medical Journal of Australia, 193(5), 285-290.
  • Churchman, A., O'Leary, M., Buckley, N., Page, C., Tankel, A., Gavaghan, C., Holdgate, A., Brown, S., Isbister, G. (2010). Clinical effects of red-bellied black snake (Pseudechis porphyriacus) envenoming and correlation with venom concentrations: Australian Snakebite Project (ASP-11). Medical Journal of Australia, 193(11-12), 696-700.
  • Gawarammana, I., Mohamed, F., Bowe, S., Rathnathilake, A., Narangoda, S., Azher, S., Dawson, A., Buckley, N. (2010). Fructose-1, 6-diphosphate (FDP) as a novel antidote for yellow oleander-induced cardiac toxicity: a randomized controlled double blind study. BMC Emergency Medicine, 10, 15-15. [More Information]
  • Moffatt, A., Mohammed, F., Eddleston, M., Azher, S., Eyer, P., Buckley, N. (2010). Hypothermia and Fever after organophosphorus poisoning in humans - a prospective case series. Journal of Medical Toxicology, 6(4), 379-385. [More Information]
  • Pearson, M., Zwi, A., Buckley, N. (2010). Prospective policy analysis: how an epistemic community informed policymaking on intentional self poisoning in Sri Lanka. Health Research Policy and Systems, 8(Article number 19), 1-11. [More Information]
  • Perera, P., Jayamanna, S., Hettiarachchi, R., Abeysinghe, C., Karunatilake, H., Dawson, A., Buckley, N. (2009). A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning. Trials, 10, 73-73. [More Information]
  • Eddleston, M., Buckley, N. (2009). A strategy for changing plasma pralidoxime kinetics and, perhaps, effect in organophosphorus insecticide poisoning. Critical Care Medicine, 39(4), 908-909. [More Information]
  • Fahim, M., Gawarammana, I., Robertson, T., Roberts, M., Palangasinghe, C., Zawahir, S., Jayamanne, S., Kandasamy, J., Eddleston, M., Buckley, N., Dawson, A., et al (2009). Acute human self-poisoning with imidacloprid compound: a neonicotinoid insecticide. PLoS One, 4, e5127. [More Information]
  • Zawahir, S., Roberts, D., Palangasinghe, C., Fahim, M., Eddleston, M., Dawson, A., Buckley, N., Ren, L., Medley, G., Gawarammana, I. (2009). Acute intentional self-poisoning with a herbicide product containing fenoxaprop-P-ethyl, ethoxysulfuron, and isoxadifen ethyl: a prospective observational study. Clinical Toxicology, 47, 792-797. [More Information]
  • Roberts, D., Heilmair, R., Buckley, N., Dawson, A., Fahim, M., Eddleston, M., Eyer, P. (2009). Clinical outcomes and kinetics of propanil following acute self-poisoning: a prospective case series. BMC Clinical Pharmacology, 9, 3. [More Information]
  • Eyer, F., Roberts, D., Buckley, N., Eddleston, M., Thiermann, H., Worek, F., Eyer, P. (2009). Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF). Biochemical Pharmacology, 78(5), 531-537. [More Information]
  • Eddleston, M., Worek, F., Eyer, P., Thiermann, H., Von Meyer, L., Jeganathan, K., Sheriff, M., Dawson, A., Buckley, N. (2009). Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos. QJM: Quarterly Journal of Medicine, 102(11), 785-792. [More Information]
  • Eddleston, M., Eyer, P., Worek, F., Juszczak, E., Alder, N., Fahim, M., Senarathna, L., Hittarage, A., Azher, S., Jeganathan, K., Dawson, A., et al (2009). Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial. PLoS Medicine, 6(6), e1000104. [More Information]
  • Gunja, N., Roberts, D., McCoubrie, D., Lamberth, P., Jan, A., Simes, D., Hackett, P., Buckley, N. (2009). Survival after massive hydroxychloroquine overdose. Anaesthesia and Intensive Care, 37(1), 130-133. [More Information]
  • Wilks, M., Fernando, R., Ariyananda, P., Eddleston, M., Berry, D., Tomenson, J., Buckley, N., Jayamanne, S., Gunnell, D., Dawson, A. (2008). mprovement in survival after paraquat ingestion following introduction of a new formulation in Sri Lanka. PLoS Medicine, 5(2), 0250-0259. [More Information]
  • Senarathna, L., Adams, J., De Silva, D., Buckley, N., Dawson, A. (2008). Personal and professional challenges in the management of deliberate self-poisoning patients in rural Sri Lanka: a qualitative study of rural hospital doctors' experiences and perceptions. BMC Public Health, 8, 1-7. [More Information]
  • Roberts, D., Buckley, N. (2008). Prolonged absorption and delayed peak paracetamol concentration following poisoning with extended-release formulation. Medical Journal of Australia, 188(5), 310-311.
  • Jayawardane, P., Dawson, A., Weerasinghe, V., Karalliede, L., Buckley, N., Senanayake, N. (2008). The spectrum of intermediate syndrome following acute organophosphate poisoning: a prospective cohort study from Sri Lanka. PLoS Medicine, 5, e147. [More Information]
  • Ringland, C., Mant, A., McGettigan, P., Mitchell, P., Kelman, C., Buckley, N., Pearson, S. (2008). Uncovering the potential risk of serotonin toxicity in Australian veterans using pharmaceutical claims data. British Journal of Clinical Pharmacology, 66(5), 682-688. [More Information]
  • Isbister, G., Friberg, L., Stokes, B., Buckley, N., Lee, C., Gunja, N., Brown, S., MacDonald, E., Graudins, A., Holdgate, A., et al (2007). Activated charcoal decreases the risk of QT prolongation after citalopram overdose. Annals of Emergency Medicine, 50(5), 593-600 +600.e1-600.e46. [More Information]
  • Eddleston, M., Buckley, N., Gunnell, D., Dawson, A., Konradsen, F. (2006). Identification of strategies to prevent death after pesticide self-poisoning using a Haddon matrix. Injury Prevention, 12, 333-337. [More Information]
  • Cooper, G., Le Couteur, D., Richardson, D., Buckley, N. (2005). A randomized clinical trial of activated charcoal for the routine management of oral drug overdose. QJM, 98(9), 655-660. [More Information]
  • Roberts, D., Buckley, N. (2005). Alkalinisation for organophosphorus pesticide poisoning. Cochrane Database of Systematic Reviews. [More Information]
  • Isbister, G., Buckley, N. (2005). Clomipramine and neuroleptic malignant syndrome: literature on adverse reactions to psychotropic drugs continues to confuse. BMJ (online). [More Information]
  • Roberts, D., Fraser, J., Buckley, N., Venkatesh, B. (2005). Experiences of anticholinesterase pesticide poisonings in an Australian tertiary hospital. Anaesthesia and Intensive Care, 33(4), 469-476. [More Information]
  • Juurlink, D., Buckley, N., Stanbrook, M., Isbister, G., Bennett, M., McGuigan, M. (2005). Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database of Systematic Reviews. [More Information]
  • Buckley, N., Isbister, G., Stokes, B., Juurlink, D. (2005). Hyperbaric oxygen for carbon monoxide poisoning: A systematic review and critical analysis of the evidence. Toxicological Reviews, 24(2), 75-92. [More Information]
  • Bromley, J., Hughes, B., Leong, D., Buckley, N. (2005). Life-threatening interaction between complementary medicines: cyanide toxicity following ingestion of amygdalin and vitamin C. The Annals of Pharmacotherapy, 39(9), 1566-9. [More Information]
  • Buckley, N., Eddleston, M., Szinicz, L. (2005). Oximes for acute organophosphate pesticide poisoning (Review). Cochrane Database of Systematic Reviews, 2005 (1), CD005085. [More Information]
  • Buckley, N. (2005). Reporting clinical research: an example of balancing a simple clinical message with data required to help future research. Emergency Medicine Australasia, 17(2), 102-3. [More Information]
  • Kerr, F., Dawson, A., Whyte, I., Buckley, N., Murray, L., Graudins, A., Chan, B., Trudinger, B. (2005). The Australasian Clinical Toxicology Investigators Collaboration Randomized Trial of Different Loading Infusion Rates of N-Acetylcysteine. Annals of Emergency Medicine, 45(4), 402-408. [More Information]
  • Buckley, N., Chevalier, S., Leditschke, A., O'Connell, D., Leitch, J., Pond, S. (2003). The limited utility of electrocardiography variables used to predict arrhythmia in psychotropic drug overdose. Critical Care, 7(5), R101-R107.
  • Whyte, I., Buckley, N., Dawson, A. (2002). Data Collection in Clinical Toxicology: Are There Too Many Variables? Journal of Toxicology. Clinical Toxicology, 40(3), 223-230.
  • Buckley, N., Whyte, I., Dawson, A. (2002). Diagnostic Data in Clinical Toxicology-Should We Use a Bayesian Approach? Journal of Toxicology. Clinical Toxicology, , 213-222.
  • Buckley, N., McManus, P. (2002). Fatal toxicity of serotoninergic and other antidepressant drugs: analysis of United Kingdom mortalilty data. BMJ: British Medical Journal, , 1332-1333.
  • Eddleston, M., Szinicz, L., Eyer, P., Buckley, N. (2002). Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials. QJM, 95(5), 275-283.
  • Eddleston, M., Karalliedde, L., Buckley, N., Fernando, R., Hutchinson, G., Isbister, G., Konradsen, F., Murray, D., Piola, J., Senanayake, N., et al (2002). Pesticide poisoning in the developing world - a minimum pesticides list. The Lancet, 360(9340), 1163-1167.
  • Eddleston, M., Rajapakshe, M., Roberts, D., Reginald, K., Sheriff, M., Dissanayake, W., Buckley, N. (2002). Severe Propanil Pesticide Self-Poisoning. Journal of Toxicology. Clinical Toxicology, 40(7), 847-854.
  • Buckley, N., Srinivasan, J. (2002). Should a Lower Treatment Line be Used When Treating Paracetamol Poisoning in Patients with Chronic Alcoholism. Drug Safety, 25(9), 619-624.

2014

  • Rajapakse, B., Neeman, T., Buckley, N. (2014). Effect of acetylcholinesterase (AChE) point-of-care testing in OP poisoning on knowledge, attitudes and practices of treating physicians in Sri Lanka. BMC Health Services Research, 14(1), 1-24. [More Information]
  • Wunnapuk, K., Liu, X., Gobe, G., Endre, Z., Peake, P., Grice, J., Roberts, M., Buckley, N. (2014). Kidney biomarkers in MCPA-induced acute kidney injury in rats: Reduced clearance enhances early biomarker performance. Toxicology Letters, 225(3), 467-478. [More Information]
  • Buckley, N., Dawson, A., Isbister, G. (2014). Serotonin syndrome. BMJ, 348, 1-4. [More Information]
  • Pearson, M., Zwi, A., Rouse, A., Fernando, R., Buckley, N., McDuie-Ra, D. (2014). Taking stock - what is known about suicide in Sri Lanka. Crisis-the Journal of Crisis Intervention and Suicide Prevention, 35(2), 390-101. [More Information]
  • Wunnapuk, K., Gobe, G., Endre, Z., Peake, P., Grice, J., Roberts, M., Buckley, N., Liu, X. (2014). Use of a glyphosate-based herbicide-induced nephrotoxicity model to investigate a panel of kidney injury biomarkers. Toxicology Letters, 225(1), 192-200. [More Information]

2013

  • Isbister, G., Buckley, N., Page, C., Scorgie, F., Lincz, L., Seldon, M., Brown, S. (2013). A randomized controlled trial of fresh frozen plasma for treating venom-induced consumption coagulopathy in cases of Australian snakebite (ASP-18). Journal of Thrombosis and Haemostasis, 11(7), 1310-1318. [More Information]
  • Roberts, D., Hall, M., Falkland, M., Strasser, S., Buckley, N. (2013). Amanita phalloides poisoning and treatment with silibinin in the Australian Capital Territory and New South Wales. Medical Journal of Australia, 198(1), 43-47. [More Information]
  • Buckley, N., Juurlink, D. (2013). Carbon monoxide treatment guidelines must acknowledge the limitations of the existing evidence. American Journal of Respiratory and Critical Care Medicine, 187(12), 1390-1390.
  • Brown, J., Buckley, N. (2013). Carbon monoxide-induced death and toxicity from charcoal briquettes. Comment. Medical Journal of Australia, 198(2), 86-86. [More Information]
  • Isbister, G., Maduwage, K., Shahmy, S., Mohamed, F., Abeysinghe, C., Karunathilake, H., Ariaratnam, C., Buckley, N. (2013). Diagnostic 20-min whole blood clotting test in Russell's viper envenoming delays antivenom administration. QJM: Quarterly Journal of Medicine, 106(10), 925-932. [More Information]
  • Senarathna, L., Buckley, N., Dibley, M., Kelly, P., Jayamanna, S., Gawarammana, I., Dawson, A. (2013). Effect of a Brief Outreach Educational Intervention on the Translation of Acute Poisoning Treatment Guidelines to Practice in Rural Sri Lankan Hospitals: A Cluster Randomized Controlled Trial. PLoS One, 8(8), 1-10. [More Information]
  • Konickx, L., Worek, F., Jayamanne, S., Thiermann, H., Buckley, N., Eddleston, M. (2013). Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides. Toxicological Sciences, 136(2), 274-283. [More Information]
  • Wunnapuk, K., Liu, X., Peake, P., Gobe, G., Endre, Z., Grice, J., Roberts, M., Buckley, N. (2013). Renal biomarkers predict nephrotoxicity after paraquat. Toxicology Letters, 222(3), 280-288. [More Information]
  • Isbister, G., Brown, S., Page, C., McCoubrie, D., Greene, S., Buckley, N. (2013). Snakebite in Australia: a practical approach to diagnosis and treatment. Medical Journal of Australia, 199(11), 763-768. [More Information]
  • Buckley, N., Dawson, A. (2013). The intralipid genie is out of the bottle-spin and wishful thinking. Anaesthesia and Intensive Care, 41(2), 154-156. [More Information]
  • Isbister, G., Buckley, N., Brown, S. (2013). Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13). Medical Journal of Australia, 198(4), 194-195. [More Information]
  • Brown, J., Buckley, N. (2013). Toxicity from bodybuilding supplements and recreational use of products containing 1,3-dimethylamylamine. Medical Journal of Australia, 198(8), 414-415. [More Information]
  • Buckley, N., Faunce, T. (2013). Trials and tribulations in the removal of dextropropoxyphene from the Australian Register of Therapeutic Goods. Medical Journal of Australia, 199(4), 257-260. [More Information]

2012

  • Senarathna, L., Jayamanna, S., Kelly, P., Buckley, N., Dibley, M., Dawson, A. (2012). Changing epidemiologic patterns of deliberate self poisoning in a rural district of Sri Lanka. BMC Public Health, 12, 1-8. [More Information]
  • Allen, G., Brown, S., Buckley, N., O'Leary, M., Page, C., Currie, B., White, J., Isbister, G., et al (2012). Clinical effects and antivenom dosing in brown snake (Pseudonaja spp.) envenoming--Australian snakebite project (ASP-14). PLoS One, 7(12), e53188. [More Information]
  • Stavrou, E., Buckley, N., Olivier, J., Pearson, S. (2012). Discontinuation of statin therapy in older people: does a cancer diagnosis make a difference? An observational cohort study using data linkage. BMJ Open, 2(3), 1-6. [More Information]
  • Eddleston, M., Adhikari, S., Egodage, S., Ranganath, H., Mohamed, F., Manuweera, G., Azher, S., Jayamanne, S., Juzczak, E., Sheriff, M., Dawson, A., et al (2012). Effects of a provincial ban of two toxic organophosphorus insecticides on pesticide poisoning hospital admissions. Clinical Toxicology, 50(3), 202-209. [More Information]
  • Jayasinghe, S., Pathirana, K., Buckley, N. (2012). Effects of acute organophosphorus poisoning on function of peripheral nerves: a cohort study. PLoS One, 7(11), e49405. [More Information]
  • Jayawardene, P., Senanayake, N., Buckley, N., Dawson, A. (2012). Electrophysiological correlates of respiratory failure in acute organophosphate poisoning: Evidence for differential roles of muscarinic and nicotinic stimulation. Clinical Toxicology, 50(4), 250-253. [More Information]
  • Stavrou, E., Lu, C., Buckley, N., Pearson, S. (2012). The role of comorbidities on the uptake of systemic treatment and 3-year survival in older cancer patients. Annals of Oncology, 23(9), 2422-2428. [More Information]
  • Senarathna, L., Buckley, N., Jayamanna, S., Kelly, P., Dibley, M., Dawson, A. (2012). Validity of referral hospitals for the toxicovigilance of acute poisoning in Sri Lanka. Bulletin of the World Health Organization, 90(6), 436-443A. [More Information]

2011

  • Pearson, M., Konradsen, F., Gunnell, D., Dawson, A., Pieris, R., Weerasinghe, M., Knipe, D., Jayamanne, S., Metcalfe, C., Hawton, K., et al (2011). A community-based cluster randomised trial of safe storage to reduce pesticide self-poisoning in rural Sri Lanka: study protocol. BMC Public Health, 11(Article no. 879), 879-1-879-8. [More Information]
  • Buckley, N., Rossi, S. (2011). Bringing greater transparency to "black box" warnings. Clinical Toxicology, 49(6), 448-451. [More Information]
  • Roberts, D., Wilks, M., Roberts, M., Swaminathan, R., Mohamed, F., Dawson, A., Buckley, N. (2011). Changes in the concentrations of creatinine, cystatin C and NGAL in patients with acute paraquat self-poisoning. Toxicology Letters, 202(1), 69-74. [More Information]
  • Williams, S., Wijesinghe, C., Jayamanne, S., Buckley, N., Dawson, A., Lalloo, D., de Silva, H. (2011). Delayed psychological morbidity associated with snakebite envenoming. PLoS Neglected Tropical Diseases, 5(8), e1255-e1255. [More Information]
  • Roberts, D., Buckley, N. (2011). Enhanced elimination in acute barbiturate poisoning - a systematic review. Clinical Toxicology, 49(1), 2-12. [More Information]
  • Rajapakse, B., Thiermann, H., Eyer, P., Worek, F., Bowe, S., Dawson, A., Buckley, N. (2011). Evaluation of the Test-mate ChE (Cholinesterase) Field Kit in Acute Organophosphorus Poisoning. Annals of Emergency Medicine, 58(6), 559-564. [More Information]
  • Wilks, M., Tomenson, J., Fernando, R., Ariyananda, R., Berry, D., Buckley, N., Gawarammana, I., Jayamanne, S., Gunnell, D., Dawson, A. (2011). Formulation changes and time trends in outcome following paraquat ingestion in Sri Lanka. Clinical Toxicology. [More Information]
  • Buckley, N., Juurlink, D., Isbister, G., Bennett, M., Lavonas, E. (2011). Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database of Systematic Reviews, 4, CD002041. [More Information]
  • Gawarammana, I., Buckley, N. (2011). Medical management of paraquat ingestion. British Journal of Clinical Pharmacology, 72(5), 745-757. [More Information]
  • Buckley, N., Eddleston, M., Li, Y., Bevan, M., Robertson, J. (2011). Oximes for acute organophosphate pesticide poisoning. Cochrane Database of Systematic Reviews, 2, CD005085. [More Information]
  • Wunnapuk, K., Medley, G., Liu, X., Grice, J., Jayasinghe, S., Gawarammana, I., Buckley, N., Roberts, M. (2011). Simple and sensitive liquid chromatography-tandem mass spectrometry methods for quantification of paraquat in plasma and urine: application to experimental and clinical toxicological studies. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 879(28), 3047-3052. [More Information]
  • Roberts, D., Dawson, A., Senarathna, L., Mohamed, F., Cheng, R., Eaglesham, G., Buckley, N. (2011). Toxicokinetics, including saturable protein binding, of 4-chloro-2-methyl phenoxyacetic acid (MCPA) in patients with acute poisoning. Toxicology Letters, 201(3), 270-276. [More Information]
  • Dawson, A., Buckley, N. (2011). Toxicologists in public health--Following the path of Louis Roche (based on the Louis Roche lecture "An accidental toxicologist in public health", Bordeaux, 2010). Clinical Toxicology, 49(2), 94-101. [More Information]

2010

  • Roberts, D., Buckley, N., Mohamed, F., Eddleston, M., Goldstein, D., Mehrsheikh, A., Bleeke, M., Dawson, A. (2010). A prospective observational study of the clinical toxicology of glyphosate-containing herbicides in adults with acute self-poisoning. Clinical Toxicology, 48(2), 129-136. [More Information]
  • Shihana, F., Dissanayake, D., Buckley, N., Dawson, A. (2010). A simple quantitative bedside test to determine methemoglobin. Annals of Emergency Medicine, 55(2), 184-185. [More Information]
  • Dawson, A., Eddleston, M., Senarathna, L., Mohamed, F., Gawarammana, I., Bowe, S., Manuweera, G., Buckley, N. (2010). Acute human lethal toxicity of agricultural pesticides: a prospective cohort study. PLoS Medicine, 7(10), e1000357. [More Information]
  • Ireland, G., Brown, S., Buckley, N., Stormer, J., Curie, B., White, J., Spain, D., Isbister, G. (2010). Changes in serial laboratory test results in snakebite patients: when can we safely exclude envenoming? Medical Journal of Australia, 193(5), 285-290.
  • Churchman, A., O'Leary, M., Buckley, N., Page, C., Tankel, A., Gavaghan, C., Holdgate, A., Brown, S., Isbister, G. (2010). Clinical effects of red-bellied black snake (Pseudechis porphyriacus) envenoming and correlation with venom concentrations: Australian Snakebite Project (ASP-11). Medical Journal of Australia, 193(11-12), 696-700.
  • Gawarammana, I., Mohamed, F., Bowe, S., Rathnathilake, A., Narangoda, S., Azher, S., Dawson, A., Buckley, N. (2010). Fructose-1, 6-diphosphate (FDP) as a novel antidote for yellow oleander-induced cardiac toxicity: a randomized controlled double blind study. BMC Emergency Medicine, 10, 15-15. [More Information]
  • Moffatt, A., Mohammed, F., Eddleston, M., Azher, S., Eyer, P., Buckley, N. (2010). Hypothermia and Fever after organophosphorus poisoning in humans - a prospective case series. Journal of Medical Toxicology, 6(4), 379-385. [More Information]
  • Pearson, M., Zwi, A., Buckley, N. (2010). Prospective policy analysis: how an epistemic community informed policymaking on intentional self poisoning in Sri Lanka. Health Research Policy and Systems, 8(Article number 19), 1-11. [More Information]

2009

  • Perera, P., Jayamanna, S., Hettiarachchi, R., Abeysinghe, C., Karunatilake, H., Dawson, A., Buckley, N. (2009). A phase II clinical trial to assess the safety of clonidine in acute organophosphorus pesticide poisoning. Trials, 10, 73-73. [More Information]
  • Eddleston, M., Buckley, N. (2009). A strategy for changing plasma pralidoxime kinetics and, perhaps, effect in organophosphorus insecticide poisoning. Critical Care Medicine, 39(4), 908-909. [More Information]
  • Fahim, M., Gawarammana, I., Robertson, T., Roberts, M., Palangasinghe, C., Zawahir, S., Jayamanne, S., Kandasamy, J., Eddleston, M., Buckley, N., Dawson, A., et al (2009). Acute human self-poisoning with imidacloprid compound: a neonicotinoid insecticide. PLoS One, 4, e5127. [More Information]
  • Zawahir, S., Roberts, D., Palangasinghe, C., Fahim, M., Eddleston, M., Dawson, A., Buckley, N., Ren, L., Medley, G., Gawarammana, I. (2009). Acute intentional self-poisoning with a herbicide product containing fenoxaprop-P-ethyl, ethoxysulfuron, and isoxadifen ethyl: a prospective observational study. Clinical Toxicology, 47, 792-797. [More Information]
  • Roberts, D., Heilmair, R., Buckley, N., Dawson, A., Fahim, M., Eddleston, M., Eyer, P. (2009). Clinical outcomes and kinetics of propanil following acute self-poisoning: a prospective case series. BMC Clinical Pharmacology, 9, 3. [More Information]
  • Eyer, F., Roberts, D., Buckley, N., Eddleston, M., Thiermann, H., Worek, F., Eyer, P. (2009). Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF). Biochemical Pharmacology, 78(5), 531-537. [More Information]
  • Eddleston, M., Worek, F., Eyer, P., Thiermann, H., Von Meyer, L., Jeganathan, K., Sheriff, M., Dawson, A., Buckley, N. (2009). Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos. QJM: Quarterly Journal of Medicine, 102(11), 785-792. [More Information]
  • Eddleston, M., Eyer, P., Worek, F., Juszczak, E., Alder, N., Fahim, M., Senarathna, L., Hittarage, A., Azher, S., Jeganathan, K., Dawson, A., et al (2009). Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial. PLoS Medicine, 6(6), e1000104. [More Information]
  • Gunja, N., Roberts, D., McCoubrie, D., Lamberth, P., Jan, A., Simes, D., Hackett, P., Buckley, N. (2009). Survival after massive hydroxychloroquine overdose. Anaesthesia and Intensive Care, 37(1), 130-133. [More Information]

2008

  • Wilks, M., Fernando, R., Ariyananda, P., Eddleston, M., Berry, D., Tomenson, J., Buckley, N., Jayamanne, S., Gunnell, D., Dawson, A. (2008). mprovement in survival after paraquat ingestion following introduction of a new formulation in Sri Lanka. PLoS Medicine, 5(2), 0250-0259. [More Information]
  • Senarathna, L., Adams, J., De Silva, D., Buckley, N., Dawson, A. (2008). Personal and professional challenges in the management of deliberate self-poisoning patients in rural Sri Lanka: a qualitative study of rural hospital doctors' experiences and perceptions. BMC Public Health, 8, 1-7. [More Information]
  • Roberts, D., Buckley, N. (2008). Prolonged absorption and delayed peak paracetamol concentration following poisoning with extended-release formulation. Medical Journal of Australia, 188(5), 310-311.
  • Jayawardane, P., Dawson, A., Weerasinghe, V., Karalliede, L., Buckley, N., Senanayake, N. (2008). The spectrum of intermediate syndrome following acute organophosphate poisoning: a prospective cohort study from Sri Lanka. PLoS Medicine, 5, e147. [More Information]
  • Ringland, C., Mant, A., McGettigan, P., Mitchell, P., Kelman, C., Buckley, N., Pearson, S. (2008). Uncovering the potential risk of serotonin toxicity in Australian veterans using pharmaceutical claims data. British Journal of Clinical Pharmacology, 66(5), 682-688. [More Information]

2007

  • Isbister, G., Friberg, L., Stokes, B., Buckley, N., Lee, C., Gunja, N., Brown, S., MacDonald, E., Graudins, A., Holdgate, A., et al (2007). Activated charcoal decreases the risk of QT prolongation after citalopram overdose. Annals of Emergency Medicine, 50(5), 593-600 +600.e1-600.e46. [More Information]

2006

  • Eddleston, M., Buckley, N., Gunnell, D., Dawson, A., Konradsen, F. (2006). Identification of strategies to prevent death after pesticide self-poisoning using a Haddon matrix. Injury Prevention, 12, 333-337. [More Information]

2005

  • Cooper, G., Le Couteur, D., Richardson, D., Buckley, N. (2005). A randomized clinical trial of activated charcoal for the routine management of oral drug overdose. QJM, 98(9), 655-660. [More Information]
  • Roberts, D., Buckley, N. (2005). Alkalinisation for organophosphorus pesticide poisoning. Cochrane Database of Systematic Reviews. [More Information]
  • Isbister, G., Buckley, N. (2005). Clomipramine and neuroleptic malignant syndrome: literature on adverse reactions to psychotropic drugs continues to confuse. BMJ (online). [More Information]
  • Roberts, D., Fraser, J., Buckley, N., Venkatesh, B. (2005). Experiences of anticholinesterase pesticide poisonings in an Australian tertiary hospital. Anaesthesia and Intensive Care, 33(4), 469-476. [More Information]
  • Juurlink, D., Buckley, N., Stanbrook, M., Isbister, G., Bennett, M., McGuigan, M. (2005). Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database of Systematic Reviews. [More Information]
  • Buckley, N., Isbister, G., Stokes, B., Juurlink, D. (2005). Hyperbaric oxygen for carbon monoxide poisoning: A systematic review and critical analysis of the evidence. Toxicological Reviews, 24(2), 75-92. [More Information]
  • Bromley, J., Hughes, B., Leong, D., Buckley, N. (2005). Life-threatening interaction between complementary medicines: cyanide toxicity following ingestion of amygdalin and vitamin C. The Annals of Pharmacotherapy, 39(9), 1566-9. [More Information]
  • Buckley, N., Eddleston, M., Szinicz, L. (2005). Oximes for acute organophosphate pesticide poisoning (Review). Cochrane Database of Systematic Reviews, 2005 (1), CD005085. [More Information]
  • Buckley, N. (2005). Reporting clinical research: an example of balancing a simple clinical message with data required to help future research. Emergency Medicine Australasia, 17(2), 102-3. [More Information]
  • Kerr, F., Dawson, A., Whyte, I., Buckley, N., Murray, L., Graudins, A., Chan, B., Trudinger, B. (2005). The Australasian Clinical Toxicology Investigators Collaboration Randomized Trial of Different Loading Infusion Rates of N-Acetylcysteine. Annals of Emergency Medicine, 45(4), 402-408. [More Information]

2003

  • Buckley, N., Chevalier, S., Leditschke, A., O'Connell, D., Leitch, J., Pond, S. (2003). The limited utility of electrocardiography variables used to predict arrhythmia in psychotropic drug overdose. Critical Care, 7(5), R101-R107.

2002

  • Whyte, I., Buckley, N., Dawson, A. (2002). Data Collection in Clinical Toxicology: Are There Too Many Variables? Journal of Toxicology. Clinical Toxicology, 40(3), 223-230.
  • Buckley, N., Whyte, I., Dawson, A. (2002). Diagnostic Data in Clinical Toxicology-Should We Use a Bayesian Approach? Journal of Toxicology. Clinical Toxicology, , 213-222.
  • Buckley, N., McManus, P. (2002). Fatal toxicity of serotoninergic and other antidepressant drugs: analysis of United Kingdom mortalilty data. BMJ: British Medical Journal, , 1332-1333.
  • Eddleston, M., Szinicz, L., Eyer, P., Buckley, N. (2002). Oximes in acute organophosphorus pesticide poisoning: a systematic review of clinical trials. QJM, 95(5), 275-283.
  • Eddleston, M., Karalliedde, L., Buckley, N., Fernando, R., Hutchinson, G., Isbister, G., Konradsen, F., Murray, D., Piola, J., Senanayake, N., et al (2002). Pesticide poisoning in the developing world - a minimum pesticides list. The Lancet, 360(9340), 1163-1167.
  • Eddleston, M., Rajapakshe, M., Roberts, D., Reginald, K., Sheriff, M., Dissanayake, W., Buckley, N. (2002). Severe Propanil Pesticide Self-Poisoning. Journal of Toxicology. Clinical Toxicology, 40(7), 847-854.
  • Buckley, N., Srinivasan, J. (2002). Should a Lower Treatment Line be Used When Treating Paracetamol Poisoning in Patients with Chronic Alcoholism. Drug Safety, 25(9), 619-624.

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