Associate Professor Nicholas Shackel

Associate Professor
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 9565 6286
Fax +61 2 9565 6101

Curriculum vitae Curriculum vitae

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Biographical details

Dr Shackel is a clinical scientist with an established tract record in academia being the recipient of multiple awards including a NHMRC Gustav-Nossal Scholarship and a NHMRC C. J. Martin Fellowship. Dr Shackel has authored 36 publications (23 as first or last author, H factor, 12) and 4 book chapters. These have consistently been at a high academic level and resulted in 679 citations (five of these manuscripts have 164, 100, 52 and 37 citations respectively).

Dr Shackel pioneered the use of functional genomics methods to study human liver. Dr Shackel¿s academic output to-date has resulted in a number of significant novel findings including: 1. Identification of a Th1 immune phenotype in HCV liver injury 2. Identification of increased WNT pathway gene expression in biliary liver disease 3. Identification of the collagen receptor DDR1 on human hepatocytes and its increased expression in human cirrhosis 4. Identification of increased RERE expression and trans-alternate splicing in HCV cirrhosis 5. Identification of EMMPRIN in human cirrhosis (funded in NHMRC project grant 512283) 6. The initial description of the Hh pathway in human liver disease (funded in NHMRC project grant 632701) Dr Shackel¿s academic output is further evidenced by the 79 abstracts accepted at national and international meetings, with 19 of these being accepted at international meetings including 11 oral presentations overseas of which one was a plenary session at AASLD and another at APASL. Dr Shackel has been awarded a number of prizes overseas for research excellence including the 1st Poster Prize at the 2002 Basel Liver Week, an American Australian Association Keith Murdoch Award in 2002, an American Liver Foundation Post-Doctoral Fellowship in 2003 and poster prize at the 2007 Australian Gastroenterology Week. Current Appointments: ¿ Staff Specialist in Gastroenterology Royal Prince Alfred Hospital Camperdown, Sydney ¿ Head of Genomic Medicine and Research Officer, Centenary Institute, Sydney ¿ Senior Lecturer, The University of Sydney (Conjoint appointment) o Teaching: Senior Lecturer, Department of Medicine University of Sydney o Lectures to Medical Students, University of Sydney. ¿ Supervision of Students and Staff: 2 RA, 5 Honours student and 6 PhD students (4 Honors students supervised by Dr Shackel in the period from 2007-2011 have all been awarded the University Medal ¿ all Honours students under Dr Shackel have been awarded independently funded PhD scholarships) Membership, Committees, Societies, Education and Professional Duties: ¿ American Association for the Study of Liver Disease ¿ Australian Society of Medical Research ¿ Gastroenterology Society of Australia ¿ Grant reviewer: NHMRC 2005 and NHMRC Review Panel 2006-2008 ¿ Journal Reviewer: Gastroenterology, PLosOne, Hepatology, GUT, American Journal of Transplantation, Liver Transplantation, Australian New Zealand Journal of Medicine and Journal of Gastroenterology and Hepatology ¿ Chair person and scientific organizer 5th Australian Meeting on Hepatitis C ¿ Conference organizer TSANZ Annual Meeting Canberra June 2010 Career Highlights: 1988 BSc University Medal Physiology and Pharmacology 1991 MB BS (Hons) (part of a combined BSc MB BS) 1997 NHMRC Gustav-Nossal Postgraduate Research Scholarship 1998 FRACP 1998 ASMR Campion-Ma-Playoust Memorial Award 2001 PhD Centenary Institute of Cancer Medicine and Cell Biology 2002 NHMRC C. J. Martin Fellow Liver Laboratory of Prof. Rockey Duke University USA 2002 American Australian Association Keith Murdoch Award 2003 American Liver Foundation Post-Doctoral Fellowship 2005 Staff Specialist Physician in Gastroenterology, Hepatology and Transplantation 2008 CIA Project Grant 512283 studying EMMPRIN in Liver Disease 2010 CIB Project Grant 632701 studying The Hedgehog Pathway in Liver Disease 2010 Organizer TSANZ Annual Meeting Canberra June 2010 2011 Appointed Head of Genomic Medicine at Centenary Institute

Research interests

To understand the molecular mechanisms regulating liver fibrosis aiming to developed novel therapeutic agents as well as developing new diagnostic investigations.

The current focus of the research group is to further understand the role of the glycoprotein CD147 in mediating basic and fundamental aspects of tissue inflammatory responses and carcinogenesis. Our group has made the fundamental discovery that CD147 mediates a process of inflammatory cell aggregation, which was previously not recognised, that mediates inflammatory responses and carcinogenesis. Taking this novel discovery from the bench through to high impact papers is the current focus of the group.

Selected grants

2014

  • The Role of the Hepatocyte and EMMPRIN in Liver Injury; Shackel N, McCaughan G, McLennan S; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Discovering novel diagnostic and prognostic markers in solid organ transplantation allograft rejection; Chadban S, Shackel N; RPA Transplant Institute/Research Support.
  • Protease therapies for diabetes-associated liver disease; Gorrell M, Keane F, Cook A, Shackel N, Seth D, Chen J, Jolly C, Hare N, McCaughan G; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2013

  • Leica PowerMosaic plus microsope upgrade for flexible, high-resolution slide scanning; Gamble J, McCaughan G, Feng C, Fazekas B, Weninger W, Shackel N, Bertolino P, Lovelace M, Saunders B, Armati P, Pollard J, Pai S, Arnold J, Triccas J, Goldsbury C, Bailey C, Mrass P, Rasko J, Biro M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • QIAxcel high throughput automated DNA, RNA and protein capillary electrophoresis system; Weninger W, Fazekas B, Feng C, Jolly C, Semsarian C, Vadas M, Bertolino P, McCaughan G, Shackel N, Bagnall R, Shklovskaya E, Bailey C; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Discovering Novel Bio Markers in Heptocellular Carcinoma; Shackel N; Sydney Foundation for Medical Research/Research Support.
  • A Novel Mechanism of Liver Injury Mediated by CD147; Shackel N; DVC Research/Bridging Support Grant.

2012

  • BD Influx 3-L Cell Sorter; Britton W, King N, Grau G, Weninger W, McCaughan G, Slobedman B, Saunders B, West N, Triccas J, Abendroth A, Combes V, Bowen D, Shackel N, Ellis M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • HCV Immunity Post Liver Transplant; Bowen D, Luciani F, Bull R, Shackel N, Bassendine M; DVC Research/Bridging Support Grant.

2011

  • Discovering Novel Non-Invasive Diagnostic and Prognostic Markers in Hepatocellular Carcinoma; Shackel N; Cancer Council New South Wales/Innovator Grant.

2010

  • High speed 3D live cell imaging of cancer genesis, growth, metastasis and death.; Weninger W, Vadas M, Richardson D, Fazekas B, Gamble J, McCaughan G, Rasko J, Shackel N, Haass N; Cancer Institute New South Wales/Equipment Grant.
  • The role of the hepatocyte hedgehog pathway in progressive liver injury; McCaughan G, Shackel N, Warner F; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • Novel Gene discovery; Shackel N; Philip Bushell Foundation/Research Support.
  • The role of the Hepatocyte in extracellular matrix interactions in Liver Fibrogenesis; Shackel N, McLennan S, Warner F; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Analysis of gene expression in peripheral blood mononuclear cells (PBMC) in chronic hepatitis C (HCV) Infection; Shackel N; Sylvia and Charles Viertel Charitable Foundation/Viertel Clinical Investigator Awards.

2002

  • Differential gene expression in hepatic wound healing; National Health and Medical Research Council (NHMRC)/Early Career Fellowships (ECF).

Selected publications

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Book Chapters

  • Shackel, N., Patel, K., McHutchison, J. (2013). Cirrhosis. In Geoffrey S. Ginsburg, Huntington F. Willard (Eds.), Genomic and Personalized Medicine, (pp. 935-954). London: Academic Press Elsevier.
  • Shackel, N., Patel, K., McHutchison, J. (2013). Viral Hepatitis. In Geoffrey S. Ginsburg, Huntington F. Willard (Eds.), Genomic and Personalized Medicine, (pp. 1173-1190). London: Academic Press Elsevier.
  • Bowen, D., Zekry, A., Bertolino, P., Shackel, N., McCaughan, G. (2009). Pathology and pathogenesis of hepatitis C. In G. Dore, M. Temple-Smith, A. Lloyd (Eds.), Hepatitis C: An Expanding Perspective, (pp. 43-75). East Hawthorn, Victoria: IP Communications.
  • McCaughan, G., Shackel, N., Williams, R., Seth, D., Haber, P., Gorrell, M. (2007). Genomics, gene arrays and proteomics in the study of liver disease. In Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, and Mario Rizzetto (Eds.), The Textbook of Hepatology: From Basic Science to Clinical Practice, (pp. 398-420). USA: Blackwell Publishers.

Journals

  • Beard, M., Ffrench, R., Gowans, E., Helbig, K., Eyre, N., Douglas, M., Grebely, J., Ahlenstiel, G., Locarnini, S., George, J., et al (2014). A Summary of the 20(th) International Symposium on Hepatitis C Virus and Related Viruses. Gastroenterology, 147(1), e1-e4. [More Information]
  • Shackel, N., Vadas, M., Gamble, J., McCaughan, G. (2014). Beyond Liver Fibrosis: Hepatic Stellate Cell Senescence Links Obesity to Liver Cancer by Way of the Microbiome. Hepatology, 59(6), 2413-2415. [More Information]
  • Grzelak, C., Martelotto, L., Sigglekow, N., Patkunanathan, B., Ajami, K., Calabro, S., Dwyer, B., Tirnitz-Parker, J., Watkins, D., Warner, F., Shackel, N., McCaughan, G. (2014). The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury. Journal of Hepatology, 60(1), 143-151. [More Information]
  • Tu, T., Shackel, N., McCaughan, G. (2013). "Testing your methyl": DNA methylation profiling of serum DNA of HCC patients. Hepatology International, 7(3), 785-787. [More Information]
  • Prakoso, E., Jones, C., Koorey, D., Strasser, S., Bowen, D., McCaughan, G., Shackel, N. (2013). Author reply: RE Terlipressin therapy for moderate to severe hyponatraemia in patients with liver failure. Internal Medicine Journal, 43(5), 607-607. [More Information]
  • Pok, S., Wen, V., Shackel, N., Alsop, A., Pyakurel, P., Fahrer, A., Farrell, G., Teoh, N. (2013). Cyclin E facilitates dysplastic hepatocytes to bypass G1/S checkpoint in hepatocarcinogenesis. Journal of Gastroenterology and Hepatology, 28(9), 1545-1554. [More Information]
  • Williams, K., Shackel, N., Gorrell, M., McLennan, S., Twigg, S. (2013). Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo. Endocrine Reviews, 34(1), 84-129. [More Information]
  • Chung, S., Shen, W., Jayawardana, K., Wang, P., Yang, J., Shackel, N., Gillies, M. (2013). Differential gene expression profiling after conditional müller-cell ablation in a novel transgenic model. Investigative Ophthalmology and Visual Science, 54(3), 2142-2152. [More Information]
  • Bowen, D., Shackel, N. (2013). Hepatitis C Pathogenesis and Outcomes After Liver Transplantation: Probing MicroRNA Expression for New Insights. Liver Transplantation, 19(4), 355-357. [More Information]
  • Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., Moses, J., Prado-Lourenco, L., Khachigian, L., Ng, M., Lichtenstein, I., Tran, N., Shackel, N., Kench, J., McCaughan, G., Vadas, M., Gamble, J., et al (2013). Regulation of vascular leak and recovery from ischaemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919. [More Information]
  • Prakoso, E., Jones, C., Koorey, D., Strasser, S., Bowen, D., McCaughan, G., Shackel, N. (2013). Terlipressin Therapy for Moderate to Severe Hyponatremia in Patients with Liver Failure. Internal Medicine Journal, 43(3), 240-246. [More Information]
  • Perera, N., Steinbeck, K., Shackel, N. (2013). The Adverse Health Consequences of the Use of Multiple Performance-Enhancing Substances - A Deadly Cocktail. Journal of Clinical Endocrinology and Metabolism, 98(12), 4613-4618. [More Information]
  • McLennan, S., Warner, F., Shackel, N. (2013). The role of CD147 in Liver Injury - "The truth is in the details" - letter to the editor. Journal of Hepatology, 58(4), 836-837. [More Information]
  • Rahman, W., Huang, P., Belov, L., Chrisp, J., Christopherson, R., Stapelberg, P., Warner, F., George, J., Bowen, D., Strasser, S., Koorey, D., Sharland, A., McCaughan, G., Shackel, N. (2012). Analysis of human liver disease using a cluster of differentiation (CD) antibody microarray. Liver International, 32(10), 1527-1534. [More Information]
  • Graaf, E., Kench, J., Dilworth, P., Shackel, N., Strasser, S., Joseph, D., Pleass, H., Crawford, M., McCaughan, G., Verran, D. (2012). Grade of Deceased Donor Liver Macrovesicular Steatosis Impacts Graft and Recipient Outcomes More than Donor Risk Index. Journal of Gastroenterology and Hepatology, 27(3), 540-546. [More Information]
  • Shackel, N. (2012). Looking into Pandoras box. Liver Transplantation, 18(3), 274-276. [More Information]
  • Tan, S., Cavanagh, L., d’Advigor, W., Shackel, N., Fazekas, B., Weninger, W. (2012). Phenotype and functions of conventional dendritic cells are not compromised in aged mice. Immunology and Cell Biology, 90(7), 722-732. [More Information]
  • Shackel, N. (2012). When has the horse bolted? Journal of Gastroenterology and Hepatology, 27(7), 1133-1134. [More Information]
  • Song, S., Shackel, N., Wang, X., Ajami, K., McCaughan, G., Gorrell, M. (2011). Discoidin Domain Receptor 1: Isoform expression and potential functions in cirrhotic human liver. The American Journal of Pathology: cellular and molecular biology of disease, 178(3), 1134-1144. [More Information]
  • McCaughan, G., Shackel, N., Bowen, D. (2011). Liver transplantation and hepatitis C: will understanding the interleukin-28B polymorphisms improve outcomes? Liver Transplantation, 17(3), 219-221. [More Information]
  • Prakoso, E., Verran, D., Dilworth, P., Kyd, G., Tang, P., Tse, C., Koorey, D., Strasser, S., Stormon, M., Shun, A., Allen, R., et al (2010). Increasing liver transplantation waiting list mortality: a report from the Australian National Liver Transplantation Unit, Sydney. Internal Medicine Journal, 40(9), 619-625. [More Information]
  • McCaughan, G., Shackel, N., Strasser, S., Dilworth, P., Tang, P. (2010). Minimal but significant improvement in survival for non-hepatitis C-related adult liver transplant patients beyond the one-year posttransplant mark. Liver Transplantation, 16(2), 130-137. [More Information]
  • Bao, W., Min, D., Twigg, S., Shackel, N., Warner, F., Yue, D., McLennan, S. (2010). Monocyte CD147 is induced by advanced glycation end products and high glucose concentration: possible role in diabetic complications. American Journal of Physiology: Cell Physiology, 299(5), C1212-C1219. [More Information]
  • Shackel, N., Bowen, D., McCaughan, G. (2010). Snipping away at hepatitis C. Hepatology, 51(2), 703-705. [More Information]
  • Shackel, N. (2010). The balancing act of hepatocyte apoptosis. Hepatology, 52(6), 2231-2233. [More Information]
  • Eckersley-Maslin, M., Grzelak, C., McCaughan, G., Shackel, N. (2009). Bone marrow stem cells and the liver: are they relevant? Journal of Gastroenterology and Hepatology, 24(10), 1608-1616. [More Information]
  • Rauch, A., James, I., Pfafferott, K., Nolan, D., Klenerman, P., Cheng, W., Mollison, L., McCaughan, G., Shackel, N., Jeffrey, G., et al (2009). Diverged Adaptation of Hepatitis C Virus Genotypes 1 and 3 to Human Leukocyte Antigen-Restricted Immune Pressure. Hepatology, 50(4), 1017-1029. [More Information]
  • Sandroussi, C., Crawford, M., Lockwood, D., Tang, P., Gallagher, J., Pleass, H., Strasser, S., Shackel, N., McCaughan, G., Verran, D. (2009). Donor and recipient selection leads to good patient and graft outcomes for right lobe split transplantation versus whole graft liver transplantation in adult recipients. Liver Transplantation, 15(11), 1586-1593. [More Information]
  • Shackel, N., Jamias, J., Rahman, W., Prakoso, E., Strasser, S., Koorey, D., Crawford, M., Verran, D., Gallagher, J., McCaughan, G. (2009). Early High Peak Hepatitis C Viral Load Levels Independently Predict Hepatitis C–Related Liver Failure Post–Liver Transplantation. Liver Transplantation, 15(7), 709-718. [More Information]
  • Gaudieri, S., Rauch, A., Pfafferott, K., Barnes, E., McCaughan, G., Shackel, N., Cheng, W., Jeffrey, G., Mollison, L., Baker, R., et al (2009). Hepatitis C Virus Drug Resistance and Immune-Driven Adaptations: Relevance to New Antiviral Therapy. Hepatology, 49(4), 1069-1082. [More Information]
  • Shackel, N. (2009). Liver tick tock".". Hepatology, 50(4), 1310-1311. [More Information]
  • McCaughan, G., Shackel, N., Bertolino, P., Bowen, D. (2009). Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes. Transplantation, 87(8), 1105-1111. [More Information]
  • Shackel, N., McCaughan, G., Warner, F. (2008). Hepatocellular carcinoma development requires hepatic stem cells with altered transforming growth factor and interleukin-6 signaling. Hepatology, 47(6), 2134-2136. [More Information]
  • Shackel, N. (2007). Growth factors as indicators of prognosis in liver failure. Journal of Gastroenterology and Hepatology, 22(8), 1171-1173. [More Information]
  • Shackel, N., Warner, F. (2007). Identification of Resident Hepatic Stem Cell Populations. Hepatology, 46. [More Information]
  • Shackel, N., McCaughan, G. (2007). Intrahepatic interferon-stimulated gene responses: Can they predict treatment responses in chronic hepatitis C infection? Hepatology (Baltimore Md.), 46(5), 1326-8. [More Information]
  • Shackel, N., McCaughan, G. (2007). Treatment for Cirrhosis-Associated Hyponatremia? Vaptans and Aquaresis. Hepatology, 45, 1080-1081. [More Information]
  • Huang, X., McCaughan, G., Shackel, N., Gorrell, M. (2007). Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis. Liver International, 27(7), 960-968. [More Information]
  • Shackel, N. (2007). Zebrafish and the understanding of liver development: the emerging role of the Wnt pathway in liver biology. Hepatology (Baltimore Md.), 45(2), 540-541. [More Information]
  • Shackel, N., Seth, D., Haber, P., Gorrell, M., McCaughan, G. (2006). The hepatic transcriptome in human liver disease. Comparative Hepatology, 5, 6-6. [More Information]
  • Shackel, N., McGuiness, P., Abbott, C., Gorrell, M., McCaughan, G. (2003). Novel differential gene expression in human cirrhosis detected by suppression substractive hybridization. Hepatology, 38(3), 577-588.
  • Shackel, N., Gorrell, M., McCaughan, G. (2002). Gene array analysis and the liver. Hepatology, 36(6), 1313-1325.
  • Shackel, N., McGuinness, P., Abbott, C., Gorrell, M., McCaughan, G. (2002). Insights into the pathobiology of hepatitis C virus-associated cirrhosis. The American Journal of Pathology: cellular and molecular biology of disease, 160(2), 641-654.
  • Shackel, N., McGuinness, P., Abbott, C., Gorell, M., McCaughan, G. (2001). Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression. Gut (English Edition): an international journal of gastroenterology and hepatology, 49, 565-576.
  • Yin, J., Shackel, N., Zekry, A., McGuinness, P., Richards, C., van der Putten, K., McCaughan, G., Eris, J., Bishop, A. (2001). Real-time reverse transcriptases-polymerase chain reaction (RT-PCR) for measurement of cytokine and growth factor mRNA expression with fluorogenic probes or SYBR Green 1. Immunology and Cell Biology, 79(3), 213-221.
  • McCaughan, G., Gorrell, M., Bishop, A., Abbott, C., Shackel, N., McGuinness, P., Levy, M., Sharland, A., Bowen, D., Yu, M., Slaitini, L., Napoli, J., et al (2000). Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunological Reviews, 174(1), 172-191.

2014

  • Beard, M., Ffrench, R., Gowans, E., Helbig, K., Eyre, N., Douglas, M., Grebely, J., Ahlenstiel, G., Locarnini, S., George, J., et al (2014). A Summary of the 20(th) International Symposium on Hepatitis C Virus and Related Viruses. Gastroenterology, 147(1), e1-e4. [More Information]
  • Shackel, N., Vadas, M., Gamble, J., McCaughan, G. (2014). Beyond Liver Fibrosis: Hepatic Stellate Cell Senescence Links Obesity to Liver Cancer by Way of the Microbiome. Hepatology, 59(6), 2413-2415. [More Information]
  • Grzelak, C., Martelotto, L., Sigglekow, N., Patkunanathan, B., Ajami, K., Calabro, S., Dwyer, B., Tirnitz-Parker, J., Watkins, D., Warner, F., Shackel, N., McCaughan, G. (2014). The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury. Journal of Hepatology, 60(1), 143-151. [More Information]

2013

  • Tu, T., Shackel, N., McCaughan, G. (2013). "Testing your methyl": DNA methylation profiling of serum DNA of HCC patients. Hepatology International, 7(3), 785-787. [More Information]
  • Prakoso, E., Jones, C., Koorey, D., Strasser, S., Bowen, D., McCaughan, G., Shackel, N. (2013). Author reply: RE Terlipressin therapy for moderate to severe hyponatraemia in patients with liver failure. Internal Medicine Journal, 43(5), 607-607. [More Information]
  • Shackel, N., Patel, K., McHutchison, J. (2013). Cirrhosis. In Geoffrey S. Ginsburg, Huntington F. Willard (Eds.), Genomic and Personalized Medicine, (pp. 935-954). London: Academic Press Elsevier.
  • Pok, S., Wen, V., Shackel, N., Alsop, A., Pyakurel, P., Fahrer, A., Farrell, G., Teoh, N. (2013). Cyclin E facilitates dysplastic hepatocytes to bypass G1/S checkpoint in hepatocarcinogenesis. Journal of Gastroenterology and Hepatology, 28(9), 1545-1554. [More Information]
  • Williams, K., Shackel, N., Gorrell, M., McLennan, S., Twigg, S. (2013). Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo. Endocrine Reviews, 34(1), 84-129. [More Information]
  • Chung, S., Shen, W., Jayawardana, K., Wang, P., Yang, J., Shackel, N., Gillies, M. (2013). Differential gene expression profiling after conditional müller-cell ablation in a novel transgenic model. Investigative Ophthalmology and Visual Science, 54(3), 2142-2152. [More Information]
  • Bowen, D., Shackel, N. (2013). Hepatitis C Pathogenesis and Outcomes After Liver Transplantation: Probing MicroRNA Expression for New Insights. Liver Transplantation, 19(4), 355-357. [More Information]
  • Young, J., Ting, K., Li, J., Moller, T., Dunn, L., Lu, Y., Moses, J., Prado-Lourenco, L., Khachigian, L., Ng, M., Lichtenstein, I., Tran, N., Shackel, N., Kench, J., McCaughan, G., Vadas, M., Gamble, J., et al (2013). Regulation of vascular leak and recovery from ischaemic injury by general and VE-cadherin-restricted miRNA antagonists of miR-27. Blood, 122(16), 2911-2919. [More Information]
  • Prakoso, E., Jones, C., Koorey, D., Strasser, S., Bowen, D., McCaughan, G., Shackel, N. (2013). Terlipressin Therapy for Moderate to Severe Hyponatremia in Patients with Liver Failure. Internal Medicine Journal, 43(3), 240-246. [More Information]
  • Perera, N., Steinbeck, K., Shackel, N. (2013). The Adverse Health Consequences of the Use of Multiple Performance-Enhancing Substances - A Deadly Cocktail. Journal of Clinical Endocrinology and Metabolism, 98(12), 4613-4618. [More Information]
  • McLennan, S., Warner, F., Shackel, N. (2013). The role of CD147 in Liver Injury - "The truth is in the details" - letter to the editor. Journal of Hepatology, 58(4), 836-837. [More Information]
  • Shackel, N., Patel, K., McHutchison, J. (2013). Viral Hepatitis. In Geoffrey S. Ginsburg, Huntington F. Willard (Eds.), Genomic and Personalized Medicine, (pp. 1173-1190). London: Academic Press Elsevier.

2012

  • Rahman, W., Huang, P., Belov, L., Chrisp, J., Christopherson, R., Stapelberg, P., Warner, F., George, J., Bowen, D., Strasser, S., Koorey, D., Sharland, A., McCaughan, G., Shackel, N. (2012). Analysis of human liver disease using a cluster of differentiation (CD) antibody microarray. Liver International, 32(10), 1527-1534. [More Information]
  • Graaf, E., Kench, J., Dilworth, P., Shackel, N., Strasser, S., Joseph, D., Pleass, H., Crawford, M., McCaughan, G., Verran, D. (2012). Grade of Deceased Donor Liver Macrovesicular Steatosis Impacts Graft and Recipient Outcomes More than Donor Risk Index. Journal of Gastroenterology and Hepatology, 27(3), 540-546. [More Information]
  • Shackel, N. (2012). Looking into Pandoras box. Liver Transplantation, 18(3), 274-276. [More Information]
  • Tan, S., Cavanagh, L., d’Advigor, W., Shackel, N., Fazekas, B., Weninger, W. (2012). Phenotype and functions of conventional dendritic cells are not compromised in aged mice. Immunology and Cell Biology, 90(7), 722-732. [More Information]
  • Shackel, N. (2012). When has the horse bolted? Journal of Gastroenterology and Hepatology, 27(7), 1133-1134. [More Information]

2011

  • Song, S., Shackel, N., Wang, X., Ajami, K., McCaughan, G., Gorrell, M. (2011). Discoidin Domain Receptor 1: Isoform expression and potential functions in cirrhotic human liver. The American Journal of Pathology: cellular and molecular biology of disease, 178(3), 1134-1144. [More Information]
  • McCaughan, G., Shackel, N., Bowen, D. (2011). Liver transplantation and hepatitis C: will understanding the interleukin-28B polymorphisms improve outcomes? Liver Transplantation, 17(3), 219-221. [More Information]

2010

  • Prakoso, E., Verran, D., Dilworth, P., Kyd, G., Tang, P., Tse, C., Koorey, D., Strasser, S., Stormon, M., Shun, A., Allen, R., et al (2010). Increasing liver transplantation waiting list mortality: a report from the Australian National Liver Transplantation Unit, Sydney. Internal Medicine Journal, 40(9), 619-625. [More Information]
  • McCaughan, G., Shackel, N., Strasser, S., Dilworth, P., Tang, P. (2010). Minimal but significant improvement in survival for non-hepatitis C-related adult liver transplant patients beyond the one-year posttransplant mark. Liver Transplantation, 16(2), 130-137. [More Information]
  • Bao, W., Min, D., Twigg, S., Shackel, N., Warner, F., Yue, D., McLennan, S. (2010). Monocyte CD147 is induced by advanced glycation end products and high glucose concentration: possible role in diabetic complications. American Journal of Physiology: Cell Physiology, 299(5), C1212-C1219. [More Information]
  • Shackel, N., Bowen, D., McCaughan, G. (2010). Snipping away at hepatitis C. Hepatology, 51(2), 703-705. [More Information]
  • Shackel, N. (2010). The balancing act of hepatocyte apoptosis. Hepatology, 52(6), 2231-2233. [More Information]

2009

  • Eckersley-Maslin, M., Grzelak, C., McCaughan, G., Shackel, N. (2009). Bone marrow stem cells and the liver: are they relevant? Journal of Gastroenterology and Hepatology, 24(10), 1608-1616. [More Information]
  • Rauch, A., James, I., Pfafferott, K., Nolan, D., Klenerman, P., Cheng, W., Mollison, L., McCaughan, G., Shackel, N., Jeffrey, G., et al (2009). Diverged Adaptation of Hepatitis C Virus Genotypes 1 and 3 to Human Leukocyte Antigen-Restricted Immune Pressure. Hepatology, 50(4), 1017-1029. [More Information]
  • Sandroussi, C., Crawford, M., Lockwood, D., Tang, P., Gallagher, J., Pleass, H., Strasser, S., Shackel, N., McCaughan, G., Verran, D. (2009). Donor and recipient selection leads to good patient and graft outcomes for right lobe split transplantation versus whole graft liver transplantation in adult recipients. Liver Transplantation, 15(11), 1586-1593. [More Information]
  • Shackel, N., Jamias, J., Rahman, W., Prakoso, E., Strasser, S., Koorey, D., Crawford, M., Verran, D., Gallagher, J., McCaughan, G. (2009). Early High Peak Hepatitis C Viral Load Levels Independently Predict Hepatitis C–Related Liver Failure Post–Liver Transplantation. Liver Transplantation, 15(7), 709-718. [More Information]
  • Gaudieri, S., Rauch, A., Pfafferott, K., Barnes, E., McCaughan, G., Shackel, N., Cheng, W., Jeffrey, G., Mollison, L., Baker, R., et al (2009). Hepatitis C Virus Drug Resistance and Immune-Driven Adaptations: Relevance to New Antiviral Therapy. Hepatology, 49(4), 1069-1082. [More Information]
  • Shackel, N. (2009). Liver tick tock".". Hepatology, 50(4), 1310-1311. [More Information]
  • McCaughan, G., Shackel, N., Bertolino, P., Bowen, D. (2009). Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes. Transplantation, 87(8), 1105-1111. [More Information]
  • Bowen, D., Zekry, A., Bertolino, P., Shackel, N., McCaughan, G. (2009). Pathology and pathogenesis of hepatitis C. In G. Dore, M. Temple-Smith, A. Lloyd (Eds.), Hepatitis C: An Expanding Perspective, (pp. 43-75). East Hawthorn, Victoria: IP Communications.

2008

  • Shackel, N., McCaughan, G., Warner, F. (2008). Hepatocellular carcinoma development requires hepatic stem cells with altered transforming growth factor and interleukin-6 signaling. Hepatology, 47(6), 2134-2136. [More Information]

2007

  • McCaughan, G., Shackel, N., Williams, R., Seth, D., Haber, P., Gorrell, M. (2007). Genomics, gene arrays and proteomics in the study of liver disease. In Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, and Mario Rizzetto (Eds.), The Textbook of Hepatology: From Basic Science to Clinical Practice, (pp. 398-420). USA: Blackwell Publishers.
  • Shackel, N. (2007). Growth factors as indicators of prognosis in liver failure. Journal of Gastroenterology and Hepatology, 22(8), 1171-1173. [More Information]
  • Shackel, N., Warner, F. (2007). Identification of Resident Hepatic Stem Cell Populations. Hepatology, 46. [More Information]
  • Shackel, N., McCaughan, G. (2007). Intrahepatic interferon-stimulated gene responses: Can they predict treatment responses in chronic hepatitis C infection? Hepatology (Baltimore Md.), 46(5), 1326-8. [More Information]
  • Shackel, N., McCaughan, G. (2007). Treatment for Cirrhosis-Associated Hyponatremia? Vaptans and Aquaresis. Hepatology, 45, 1080-1081. [More Information]
  • Huang, X., McCaughan, G., Shackel, N., Gorrell, M. (2007). Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis. Liver International, 27(7), 960-968. [More Information]
  • Shackel, N. (2007). Zebrafish and the understanding of liver development: the emerging role of the Wnt pathway in liver biology. Hepatology (Baltimore Md.), 45(2), 540-541. [More Information]

2006

  • Shackel, N., Seth, D., Haber, P., Gorrell, M., McCaughan, G. (2006). The hepatic transcriptome in human liver disease. Comparative Hepatology, 5, 6-6. [More Information]

2003

  • Shackel, N., McGuiness, P., Abbott, C., Gorrell, M., McCaughan, G. (2003). Novel differential gene expression in human cirrhosis detected by suppression substractive hybridization. Hepatology, 38(3), 577-588.

2002

  • Shackel, N., Gorrell, M., McCaughan, G. (2002). Gene array analysis and the liver. Hepatology, 36(6), 1313-1325.
  • Shackel, N., McGuinness, P., Abbott, C., Gorrell, M., McCaughan, G. (2002). Insights into the pathobiology of hepatitis C virus-associated cirrhosis. The American Journal of Pathology: cellular and molecular biology of disease, 160(2), 641-654.

2001

  • Shackel, N., McGuinness, P., Abbott, C., Gorell, M., McCaughan, G. (2001). Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression. Gut (English Edition): an international journal of gastroenterology and hepatology, 49, 565-576.
  • Yin, J., Shackel, N., Zekry, A., McGuinness, P., Richards, C., van der Putten, K., McCaughan, G., Eris, J., Bishop, A. (2001). Real-time reverse transcriptases-polymerase chain reaction (RT-PCR) for measurement of cytokine and growth factor mRNA expression with fluorogenic probes or SYBR Green 1. Immunology and Cell Biology, 79(3), 213-221.

2000

  • McCaughan, G., Gorrell, M., Bishop, A., Abbott, C., Shackel, N., McGuinness, P., Levy, M., Sharland, A., Bowen, D., Yu, M., Slaitini, L., Napoli, J., et al (2000). Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunological Reviews, 174(1), 172-191.

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