Professor Roland Stocker

Professor of Biochemistry in Vascular Medicine
Pathology, School of Medical Sciences
Bosch Institute

K25 - Medical Foundation Building
The University of Sydney
NSW 2006 Australia

T: +61 2 9036 3207
F: +61 2 9036 3038
E:

Biographical details

Roland Stocker received his training as a biochemist at the ETH Zürich (Switzerland), ANU (Canberra, Australia) and the University of California (Berkeley, USA). Following an appointment as Assistant Professor at the University of Berne (Switzerland), Roland moved permanently to Australia in 1988 where he worked as Group Leader at the Heart Research Institute for 13 years, as a Professor at the Centre for Vascular Research at the University of New South Wales for 5 years, before taking up a Professorial Chair at the University of Sydney in late 2006. [More...]

Research interests

Our research focuses on the hardening of blood vessels (a process also called atherosclerosis) that is the single major cause of heart attacks and stroke, and hence death, in Australia. We study the contribution of oxidation to atherosclerosis, and how the disease can be inhibited. We have identified a protein, the up-regulation of which affects many biological processes, resulting in the inhibition of disease in several animal models. We are now studying how a change in a single protein can have such multiple biological effects. We also have discovered a novel protein that regulates the tone of blood vessels and blood pressure in conditions of inflammation, and are now seeking to better understand the underlying principles of this action. Finally, we have established a new Core Facility to assess oxidative stress in vitro and in vivo, and we are developing new methods and tools to apply this to cardiovascular and other research.

Current national competitive grants*

2012

NOX enzymes as mediators of inflammation-triggered neurodegeneration: modulating NOX enzymes as novel therapies
Stocker R
NHMRC NHMRC-European Collaborative Research Grant ($949,792 over 4 years)

Does inhibition of myeloperoxidase attenuate atherosclerosis?
Stocker R, Kettle A
NHMRC Project Grants ($546,073 over 3 years)

A novel pathway for the regulation of vascular tone
Stocker R, Payne R
NHMRC Project Grants ($569,685 over 3 years)

Heme Oxygenase Integrates Cellular Responses to Oxygen Stress
Stocker R, Clarke C, Madeo F
ARC Discovery Projects ($360,000 over 3 years)

2011

Senior Principal Research Fellowship
Stocker R
NHMRC Career Award: Research Fellowship ($905,805 over 5 years)

* Grants administered through the University of Sydney

International links

Finland. (University of Eastern Finland) Seppo Ylä-Herttuala: Inhibitors of myeloperoxidase as anti-atherosclerotic agents.
Sweden. (Karolinska Institute) Rikard Holmdahl: NOX enzymes as mediators of inflammation-triggered neurodegeneration. FP7 Project NEURINOX Tomas Olsson: NOX enzymes as mediators of inflammation-triggered neurodegeneration. FP7 Project NEURINOX.
Germany. (Bayer Schering Pharma AG) Johannes-Peter Stasch: Novel activators of soluble guanylate cyclase derived from tryptophan metabolism by indoleamine 2,3-dioxygenase.
Greece. (Biomedical Research Foundation Academy of Athens) Antonia Vlahou: NOX enzymes as mediators of inflammation-triggered neurodegeneration. FP7 Project NEURINOX.
Singapore. (National University of Singapore) Professors Barry Halliwell and Frank Watt: Mechanisms of vascular protection by haem oxygenase - changes in the elemental metal composition in the artery wall..
Italy. (University of Torino) Adriano Chio: NOX enzymes as mediators of inflammation-triggered neurodegeneration. FP7 Project NEURINOX.
Greece. (University of Athens) Despina Sanoudou: NOX enzymes as mediators of inflammation-triggered neurodegeneration. FP7 Project NEURINOX.
Sweden. (AstraZeneca Mölndal) Eva-Lotte Lindstedt: The potential of inhibitors of myeloperoxidase as novel agents to treat cardiovascular disease.
New Zealand. (University of Otago) Anthony Kettle: Inhibitors of myeloperoxidase as anti-atherosclerotic agents Mark Hampton: Changes to cellular redox state during endotoxemia.
Switzerland. (University of Zürich) Dominik Schaer: Cellular adaption to heme oxygenase-1 - a proteomics approach Adriano Aguzzi: NOX enzymes as mediators of inflammation-triggered neurodegeneration. FP7 Project NEURINOX.
France. (Joseph Fourier University) Antoine Depaulis: NOX enzymes as mediators of inflammation-triggered neurodegeneration. FP7 Project NEURINOX.
United States. (University of California, Los Angeles) Catherine F Clarke: A novel link between heme oxygenase-1 and mitochondrial function.
Austria. (University of Graz) Frank Madeo: Heme oxygenase-1 and life expectancy in yeast Wolfgang Sattler: Novel tools to assess the breakdown of the brain blood barrier.
Sweden. (AstraZeneca Mölndal) Eva-Lotte Lindstedt: The potential of inhibitors of myeloperoxidase as novel agents to treat cardiovascular disease.
Switzerland. (University of Geneva) Professor Beat Imhof: Role of heme oxygenases and indoleamine 2,3-dioxygenase in angiogenesis. Karl-Heinz Krause: NOX enzymes as mediators of inflammation-triggered neurodegeneration. FP7 Project NEURINOX Richard Fish: Participation of heme oxygenase-1 in embryonic development.
United States. (University of Massachusetts Medical School) Professor John Keaney.
Switzerland. (University of Berne) Stefan Christen: Oxidative stress associated with meningitis.