Professor Tailoi Chan-Ling
Professor of Neurobiology & Visual Science
F13 - Anderson Stuart Building
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Dr Chan-Ling has made a sustained contribution to the understanding of glial-vascular biology during normal CNS development as well as key understanding to the disease processes in Retinopathy of Prematurity (the leading cause of infant blindness in the world) animal models of multiple sclerosis, cerebral malaria and inflammation.
Current national competitive grants*
Rationale for non-invasive treatment of Retinopathy of Prematurity: Dark Rearing as a means of mimicking physiological vascularisation
National Health and Medical Research Council Project Grant ($399,615 over 3 years)
NHMRC Principal Research Fellowship
NHMRC Research Fellowships ($677,500 over 5 years)
* Grants administered through the University of Sydney
PhD and Masters' project opportunities
United Kingdom. (Department of Opthalmology & Visual Science, Queens University Belfast.) Dr Tom Gardiner - Collaborative studies utilising transmission electron microscopy to characterise changes in pericyte and smooth muscle cell ensheathment of retinal and choroidal blood vessels during normal development, in disease and in aging.
Chan-Ling T, Page M, Gardiner T, Baxter L and Hughes S, Desmin Ensheathment ratio (DER) as an indicator of vessel stability: Evidence in normal development and in Retinopathy of prematurity (2004) 165(4) American Journal of Pathology 1301.
Hughes S, Gardiner T, Hu P, Baxter E, Rosinova E and Chan-Ling T, Altered pericyte-endothelial relationship during physiological aging: Implications for vessel stability (2006) 27(12) Neurobiology of Aging 1838. E article, available, Nov 2005. http://linkinghub.elsevier.com/retrieve/pii/S0197458005003490
Hughes S, Gardiner T, Baxter L, Chan-Ling T, Changes in pericytes and smooth muscle cells in the kitten model of Retinopathy of Prematurity (ROP): Implications for plus disease (2007) 48 Investigative Ophthalmology and Visual Science 1368-1379..
United States. (Department of Pharmacology & Therapeutics, University of Florida) Professor Maria Grant - Collaborative studies to maximise the repair functions of hematopoietic stem cells in stemming vision loss. Two grants awarded to Professor Chan-Ling (International Science Linkages grant, Department of Education, Science and Technology). Publications arising: Chan-Ling T, Baxter L, Afzal A, Sengupta N, Caballero S, Rosinova E and Grant MB, Hematopoietic stem cells provide repair functions after laser-induced Bruchs membrane rupture model of choroidal neovascularisation (2006) 168 American Journal of Pathology 1031. Chang KH, Chan-Ling T, McFarland EL, Afzal A, Pan H, Baxter LC, Shaw LC, Caballero S, Sengupta N, Calzi SL, Sullivan SM, and Grant MB, IGF Binding Protein-3 Regulates Hematopoietic Stem and Endothelial Precursor Cell Differentiation, Migration and Retinal Development (2007) 104 Proceedings of the National Academy of Sciences (PNAS) 10595 Kielczewski JL, McFarland EL, Jarajapu Y, Afzal A, Calzi S, Chang KH, Lydic T, Shaw LC, Busik J, Hughes J, Cardounel AJ, Wilson K, Lyons TJ, Cai J, Boulton ME, Mames RN, Gardiner T, Chan-Ling T, and Grant MB, Insulin-like growth factor binding protein-3 (IGFBP-3) mediates vascular repair by enhancing nitric oxide generation. (2009) J Circulation Research. Accepted.
United States. (Department of Neurology, University of Washington) Undertook lab visit in January 2008 to gain training in the application of the Helios Gene Gun for complete visualisation of cell morphology. Future visits will provide further experience with HPLC and imaging of ion sensitive dyes with the aim of gaining insights into glial, neuronal and vascular interactions using the rat retinal wholemount preparation. Calcium imaging and hemichannels on human fetal astrocytes. Publication arising: Co-authored a comprehensive review of astrocyte developmental biology and astrocyte function, Ransom and Chan-Ling, In Youmans Neurological Surgery, 2004..
Australia. (Canberra Hospital, Australian National University) Collaborative work with Professor Jane Dahlstrom - Histopathologist. Publications arising: Cellular and molecular mechanisms of formation of the human choroidal and retinal vasculature. Papers arising: Chan-Ling T, Baxter LC, Sterling RA, Dahlstrom J, Bean EG, Hughes S, Human choroidal formation takes place via hematopoietic differentiation, vasculogenesis and angiogenesis Submitted for publication..
United States. (Harkness Eye Institute, Columbia University) Professor John Flynn - Understanding Retinopathy of Prematurity: The Gift of Sight. Professor Chan-Ling currently holds the appointment of Adjunct Professor of Ophthalmic Science(Ophthalmology),Harkness Eye Institute, Columbia University Medical Center New York, USA Publication arising: ROP, Two distinct mechanisms underlying Zone 1 Zone 2 disease (2006) 142 American Journal of Ophthalmology 46.