Dr Alyson Ashe

School of Life and Environmental Sciences

G08 - Biochemistry and Microbiology Building
The University of Sydney

Biographical details

Dr Ashe is an early career research fellow in the School of Life and Environmental Sciences. She is interested in all areas of epigenetics and small RNA molecules.

She completed her undergraduate degree in Molecular Biology and Genetics at the University of Sydney, and her PhD at the University of Sydney and the Queensland Institute of Medical Research. After three years in Brisbane she moved to The Gurdon Institute in Cambridge, UK, where she spent four years as a postdoctoral research fellow.

During her PhD Dr Ashe developed a fascination with the area of epigenetics using mice as a model organism. She kept up this interest but broadened her horizons by moving to a new model organism (the nematode worm C. elegans) and the world of RNA molecules during her postdoctoral work.

Research interests

Dr Ashe studies epigenetic regulation of gene expression: the interplay between the environment that an organism encounters during its lifetime, and the expression patterns of its genes. Importantly, these environmental signals can sometimes get passed between generations (Darwin was wrong!), and Dr Ashe's work is trying to understand how this occurs.

To do this Dr Ashe mainly uses the model organism C. elegans, a small nematode worm, but is also branching out into other species such as the honey bee.

Current research students

Project title Research student
Investigating the mechanisms of transgenerational epigenetic inheritance in Caenorhabditis elegans Rachel WOODHOUSE

Awards and honours

Lorne Genome Conference Women in Science Award 2016

Centenary Institute Lawrence Creative Prize (Shortlised) 2015

ARC Discovery Early Career Researcher Award 2014

Themes

Environment; Molecular biology and biotechnology; Genetics and genomics

Selected grants

2015

  • Parental imprinting and epigenetic inheritance in honey bees; Oldroyd B, Ashe A; Australian Research Council (ARC)/Discovery Projects (DP).

2014

  • Determining the mechanisms of transgenerational epigenetic inheritance.; Ashe A; Australian Research Council (ARC)/Discovery Early Career Researcher Award (DECRA).

Selected publications

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Journals

  • Remnant, E., Shi, M., Buchmann, G., Blacquiere, T., Holmes, E., Beekman, M., Ashe, A. (2017). A Diverse Range of Novel RNA Viruses in Geographically Distinct Honey Bee Populations. Journal of Virology, 91(16), e00158-17. [More Information]
  • Remnant, E., Ashe, A., Young, P., Buchmann, G., Beekman, M., Allsopp, M., Suter, C., Drewell, R., Oldroyd, B. (2016). Parent-of-origin effects on genome-wide DNA methylation in the Cape honey bee (Apis mellifera capensis) may be confounded by allele-specific methylation. BMC Genomics, 17(1), 1-14. [More Information]
  • Ashe, A., Sarkies, P., Le Pen, J., Tanguy, M., Miska, E. (2015). Antiviral RNA against Orsay virus is neither systemic nor transgenerational in Caenorhabditis elegans. Journal of Virology, 89(23), 12035-12046. [More Information]
  • Ashe, A., Bélicard, T., Le Pen, J., Sarkies, P., Frézal, L., Lehrbach, N., Félix, M., Miska, E. (2013). A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity. eLife, 2, e00994. [More Information]
  • Daxinger, L., Harten, S., Oey, H., Epp, T., Isbel, L., Huang, E., Whitelaw, N., Apedaile, A., Sorolla, A., Yong, J., et al (2013). An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biology, 14(9), 1-17. [More Information]
  • Sarkies, P., Ashe, A., Le Pen, J., McKie, M., Miska, E. (2013). Competition between virus-derived and endogenous small RNAs regulates gene expression in Caenorhabditis elegans. Genome Research, 23(8), 1258-1270. [More Information]
  • Youngson, N., Epp, T., Roberts, A., Daxinger, L., Ashe, A., Huang, E., Lester, K., Harten, S., Kay, G., Cox, T., Matthews, J., et al (2013). No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations. Mammalian Genome, 24(5-6), 206-217. [More Information]
  • Daxinger, L., Oey, H., Apedaile, A., Sutton, J., Ashe, A., Whitelaw, E. (2012). A Forward Genetic Screen Identifies Eukaryotic Translation Initiation Factor 3, Subunit H (eIF3h), as an Enhancer of Variegation in the Mouse. G3: Genes, Genomes, Genetics, 2(11), 1393-1396. [More Information]
  • Ashe, A., Butterfield, N., Town, L., Courtney, A., Cooper, A., Ferguson, C., Barry, R., Olsson, F., Liem, K., Parton, R., et al (2012). Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Human Molecular Genetics, 21(8), 1808-1823. [More Information]
  • Ashe, A., Sapetschnig, A., Weick, E., Mitchell, J., Bagijn, M., Cording, A., Doebley, A., Goldstein, L., Lehrbach, N., Le Pen, J., et al (2012). piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans. Cell, 150(1), 88-99. [More Information]
  • Liem, K., Ashe, A., He, M., Satir, P., Moran, J., Beier, D., Wicking, C., Anderson, K. (2012). The IFT-A complex regulates Shh signalling through cilia structure and membrane protein trafficking. The Journal of Cell Biology, 197(6), 789-800. [More Information]
  • Felix, M., Ashe, A., Piffaretti, J., Wu, G., Nuez, I., Belicard, T., Jiang, Y., Zhao, G., Franz, C., Goldstein, L., et al (2011). Natural and Experimental Infection of Caenorhabditis Nematodes by Novel Viruses Related to Nodaviruses. PLoS Biology, 9(1), 1-14. [More Information]
  • Whitelaw, N., Chong, S., Morgan, D., Nestor, C., Bruxner, T., Ashe, A., Lambley, E., Meehan, R., Whitelaw, E. (2010). Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise. Genome Biology, 11, R111. [More Information]
  • Ashe, A., Morgan, D., Whitelaw, N., Bruxner, T., Vickaryous, N., Cox, L., Butterfield, N., Wicking, C., Blewitt, M., Wilkins, S., et al (2008). A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biology, 9, R182. [More Information]
  • Chong, S., Vickaryous, N., Ashe, A., Zamudio, N., Youngson, N., Hemley, S., Stopka, T., Skoultchi, A., Matthews, J., Scott, H., Blewitt, M., et al (2007). Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nature Genetics, 39(5), 614-622. [More Information]
  • Blewitt, M., Vickaryous, N., Hemley, S., Ashe, A., Bruxner, T., Preis, J., Arkell, R., Whitelaw, E. (2005). An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 102(21), 7629-7634. [More Information]
  • Ashe, A., Oldroyd, B. (2003). Do queens select sperm?: Response from Ashe and Oldroyd. Trends in Ecology and Evolution, 18(3), 108-108. [More Information]
  • Ashe, A., Oldroyd, B. (2002). Genetic determination of caste in harvester ants. Trends in Ecology and Evolution, 17(10), 448-449. [More Information]

2017

  • Remnant, E., Shi, M., Buchmann, G., Blacquiere, T., Holmes, E., Beekman, M., Ashe, A. (2017). A Diverse Range of Novel RNA Viruses in Geographically Distinct Honey Bee Populations. Journal of Virology, 91(16), e00158-17. [More Information]

2016

  • Remnant, E., Ashe, A., Young, P., Buchmann, G., Beekman, M., Allsopp, M., Suter, C., Drewell, R., Oldroyd, B. (2016). Parent-of-origin effects on genome-wide DNA methylation in the Cape honey bee (Apis mellifera capensis) may be confounded by allele-specific methylation. BMC Genomics, 17(1), 1-14. [More Information]

2015

  • Ashe, A., Sarkies, P., Le Pen, J., Tanguy, M., Miska, E. (2015). Antiviral RNA against Orsay virus is neither systemic nor transgenerational in Caenorhabditis elegans. Journal of Virology, 89(23), 12035-12046. [More Information]

2013

  • Ashe, A., Bélicard, T., Le Pen, J., Sarkies, P., Frézal, L., Lehrbach, N., Félix, M., Miska, E. (2013). A deletion polymorphism in the Caenorhabditis elegans RIG-I homolog disables viral RNA dicing and antiviral immunity. eLife, 2, e00994. [More Information]
  • Daxinger, L., Harten, S., Oey, H., Epp, T., Isbel, L., Huang, E., Whitelaw, N., Apedaile, A., Sorolla, A., Yong, J., et al (2013). An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Genome Biology, 14(9), 1-17. [More Information]
  • Sarkies, P., Ashe, A., Le Pen, J., McKie, M., Miska, E. (2013). Competition between virus-derived and endogenous small RNAs regulates gene expression in Caenorhabditis elegans. Genome Research, 23(8), 1258-1270. [More Information]
  • Youngson, N., Epp, T., Roberts, A., Daxinger, L., Ashe, A., Huang, E., Lester, K., Harten, S., Kay, G., Cox, T., Matthews, J., et al (2013). No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations. Mammalian Genome, 24(5-6), 206-217. [More Information]

2012

  • Daxinger, L., Oey, H., Apedaile, A., Sutton, J., Ashe, A., Whitelaw, E. (2012). A Forward Genetic Screen Identifies Eukaryotic Translation Initiation Factor 3, Subunit H (eIF3h), as an Enhancer of Variegation in the Mouse. G3: Genes, Genomes, Genetics, 2(11), 1393-1396. [More Information]
  • Ashe, A., Butterfield, N., Town, L., Courtney, A., Cooper, A., Ferguson, C., Barry, R., Olsson, F., Liem, K., Parton, R., et al (2012). Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. Human Molecular Genetics, 21(8), 1808-1823. [More Information]
  • Ashe, A., Sapetschnig, A., Weick, E., Mitchell, J., Bagijn, M., Cording, A., Doebley, A., Goldstein, L., Lehrbach, N., Le Pen, J., et al (2012). piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans. Cell, 150(1), 88-99. [More Information]
  • Liem, K., Ashe, A., He, M., Satir, P., Moran, J., Beier, D., Wicking, C., Anderson, K. (2012). The IFT-A complex regulates Shh signalling through cilia structure and membrane protein trafficking. The Journal of Cell Biology, 197(6), 789-800. [More Information]

2011

  • Felix, M., Ashe, A., Piffaretti, J., Wu, G., Nuez, I., Belicard, T., Jiang, Y., Zhao, G., Franz, C., Goldstein, L., et al (2011). Natural and Experimental Infection of Caenorhabditis Nematodes by Novel Viruses Related to Nodaviruses. PLoS Biology, 9(1), 1-14. [More Information]

2010

  • Whitelaw, N., Chong, S., Morgan, D., Nestor, C., Bruxner, T., Ashe, A., Lambley, E., Meehan, R., Whitelaw, E. (2010). Reduced levels of two modifiers of epigenetic gene silencing, Dnmt3a and Trim28, cause increased phenotypic noise. Genome Biology, 11, R111. [More Information]

2008

  • Ashe, A., Morgan, D., Whitelaw, N., Bruxner, T., Vickaryous, N., Cox, L., Butterfield, N., Wicking, C., Blewitt, M., Wilkins, S., et al (2008). A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development. Genome Biology, 9, R182. [More Information]

2007

  • Chong, S., Vickaryous, N., Ashe, A., Zamudio, N., Youngson, N., Hemley, S., Stopka, T., Skoultchi, A., Matthews, J., Scott, H., Blewitt, M., et al (2007). Modifiers of epigenetic reprogramming show paternal effects in the mouse. Nature Genetics, 39(5), 614-622. [More Information]

2005

  • Blewitt, M., Vickaryous, N., Hemley, S., Ashe, A., Bruxner, T., Preis, J., Arkell, R., Whitelaw, E. (2005). An N-ethyl-N-nitrosourea screen for genes involved in variegation in the mouse. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 102(21), 7629-7634. [More Information]

2003

  • Ashe, A., Oldroyd, B. (2003). Do queens select sperm?: Response from Ashe and Oldroyd. Trends in Ecology and Evolution, 18(3), 108-108. [More Information]

2002

  • Ashe, A., Oldroyd, B. (2002). Genetic determination of caste in harvester ants. Trends in Ecology and Evolution, 17(10), 448-449. [More Information]

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