Dr Angela D'Rozario

BSc(Hons) RPSGT PhD
NHMRC-ARC Dementia Research Development Research Fellow - School of Psychology
Research Leader, Sleep Neurobiology Theme - CIRUS, Centre for Sleep and Chronobiology, Woolcock Institute of Medical Research

M02F - 88 Mallett Street - Building F
The University of Sydney

Telephone 02 91140435
Fax 02 9114 0014

Website Contact Details
Research Gate
CIRUS Centre for Sleep and Chronobiology

Biographical details

Dr D’Rozario is an early career clinical researcher and NHMRC-ARC Dementia Research Fellow at the School of Psychology, University of Sydney and NHMRC NeuroSleep Centre of Research Excellence (CRE), Woolcock Institute. She leads the Facility for High-density Electroencephalography Investigation at the University of Sydney and is Research Leader, Sleep Neurobiology Theme at CIRUS, Centre for Sleep and Chronobiology. She was recently awarded an NHMRC-ARC Dementia Research Development Fellowship (2016-20) for her work investigating links between abnormal sleep neurophysiology and cognitive decline in dementia.

After completing her Bachelor’s degree in Applied Biological Sciences (Hons) in Bristol, UK she trained as a sleep technologist at St Thomas’ Hospital (London, UK) and later moved to Sydney in 2004 to work with leading sleep expert Prof Ron Grunstein. She has been a credentialed Registered Polysomnographic Technologist since 2005. She has more than 15 years’ experience in the field of sleep medicine and has successfully managed two NHMRC Centres of Clinical Research Excellence in Interdisciplinary Sleep Health (2009-13) and Respiratory and Sleep Medicine (2005-9). She was a recipient of the prestigious NHMRC Dora Lush Priority PhD Scholarship to examine novel brain activity biomarkers of cognitive dysfunction and sleepiness in obstructive sleep apnea (OSA). She was awarded her PhD in Sleep Medicine in 2014 at Sydney Medial School, University of Sydney. Dr D’Rozario has expertise in advanced neurophysiology techniques, neurocognitive assessments and clinical sleep research methodologies. She has led several projects to develop and validate novel quantitative electroencephalography (EEG) analysis tools and currently leads the sleep neurobiology research program using high-density EEG.

Research interests

The research undertaken by the Sleep Neurobiology Research Team provides neurophysiology and imaging insights into cognitive deficits in sleep disorders and neurodegenerative disease. Our work aims to discover new clinical brain-based biomarkers to differentiate between patient phenotypes i.e. identify those sleep-disordered patients who are at high-risk of having a fall-asleep motor vehicle accident. We also examine how altered brain activity during sleep may be risk factors for cognitive impairment and neurodegeneration. We investigate interventions for optimizing sleep brain activity to restore normal sleeping patterns and improve sleep-dependent cognitive processes.
Technological advances in measuring brain activity using our new high-density electroencephalography (hdEEG) system together with our neuroimaging expertise provide a powerful platform for our growing research program. We use these tools to investigate functional brain activity and neurobiological pathology in patients with sleep disorders and neurodegenerative disease, and to evaluate novel treatment approaches aimed at improving sleep, cognition and clinical outcomes.

Teaching and supervision

Dr D’Rozario currently co-supervises 1 Honours and 3 PhD students. Her 3 completed Honours students have been awarded 1st class Honours.

Current research students

Project title Research student
Characterising and optimising sleep dependant memory (SDM) in mild cognitive impaired (MCI) subtypes Carla HAROUTONIAN

Current projects

Current Sleep Neurobiology Research projects include:

Obstructive Sleep Apnea (OSA)
• Identifying predictors of vulnerability to alertness failure after extended time awake in OSA
• Examining the links between sleep spindles and overnight implicit memory consolidation
• Investigating the effect of CPAP treatment on altered sleep spindles and slow wave activity during sleep and cognitive performance
• Investigating the effect of 40-h of sleep deprivation on brain activity during sleep/wake and performance

Insomnia
• Measuring brain activity during the transition from wake to sleep to distinguish different types of insomnia patients
• Understanding brain changes using neuroimaging and hdEEG to better understand Chronic Fatigue Syndrome and non-restorative sleep

Mild Cognitive Impairment (MCI)
• Exploring the relationship between sleep quality and sleep-dependent memory consolidation in individuals at high-risk of developing dementia

Schizophrenia
• Identifying new biomarkers of cognitive deficits using hdEEG and targeting sleep to improve clinical outcomes in schizophrenia

Associations

American Association of Sleep Technologists. 2005-Present

Australasian Sleep Technologists Association. 2005-Present

Australasian Sleep Association. 2014-Present

Sleep Research Society. 2013-Present

British Sleep Society. 2002-Present

In the media

The Sydney Morning Herald article: Two for one: lose sleep and brain cells http://www.smh.com.au/lifestyle/life/two-for-one-lose-sleep-and-brain-cells-20140321-358m0.html

Selected grants

2017

  • 31st Annual Meeting of the Associated Professional Sleep Societies (APSS) - Ian Potter Travel grant; D'Rozario A; Ian Potter Foundation/Travel Support.

2016

  • Sleep, plasticity and neurodegeneration: Targeting sleep to improve cognitive in Mild Cognitive Impairment (MCI); D'Rozario A; National Health and Medical Research Council (NHMRC)/NHMRC-ARC Dementia Research Development Fellowships.

Selected publications

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Journals

  • Miller, C., Rae, C., Green, M., Yee, B., Gordon, C., D'Rozario, A., Kyle, S., Espie, C., Grunstein, R., Bartlett, D. (2017). An Objective Short Sleep Insomnia Disorder Subtype Is Associated With Reduced Brain Metabolite Concentrations In Vivo: A Preliminary Magnetic Resonance Spectroscopy Assessment. Sleep. [More Information]
  • Zobaer, M., Anderson, R., Kerr, C., Robinson, P., Wong, K., D'Rozario, A. (2017). K-complexes, spindles, and ERPs as impulse responses: unification via neural field theory. Biological Cybernetics, 111(2), 149-164. [More Information]
  • Szentkiralyi, A., Wong, K., Grunstein, R., D'Rozario, A., Kim, J. (2017). Performance of an automated algorithm to process artefacts for quantitative EEG analysis during a simultaneous driving simulator performance task. International Journal of Psychophysiology, 121, 12-17. [More Information]
  • Miller, C., Bartlett, D., Mullins, A., Dodds, K., Gordon, C., Kyle, S., Kim, J., D'Rozario, A., Lee, R., Comas, M., Marshall, N., Yee, B., Grunstein, R., et al (2016). Clusters of Insomnia Disorder: An Exploratory Cluster Analysis of Objective Sleep Parameters Reveals Differences in Neurocognitive Functioning, Quantitative EEG, and Heart Rate Variability. Sleep, 39(11), 1993-2004. [More Information]
  • Vakulin, A., D'Rozario, A., Kim, J., Watson, B., Cross, N., Wang, D., Coeytaux Jackson, A., Bartlett, D., Wong, K., Grunstein, R. (2016). Quantitative sleep EEG and polysomnographic predictors of driving simulator performance in obstructive sleep apnea. Clinical Neurophysiology, 127(2), 1428-1435. [More Information]
  • Miller, C., Gordon, C., Toubia, L., Bartlett, D., Grunstein, R., D'Rozario, A., Marshall, N. (2015). Agreement between simple questions about sleep duration and sleep diaries in a large online survey. Sleep Health, 1(2), 133-137. [More Information]
  • D'Rozario, A., Dungan, G., Banks, S., Liu, P., Wong, K., Killick, R., Grunstein, R., Kim, J. (2015). An automated algorithm to identify and reject artefacts for quantitative EEG analysis during sleep in patients with sleep-disordered breathing. Sleep and Breathing, 19(2), 607-615. [More Information]
  • Serinel, Y., Marshall, N., D'Rozario, A., Crawford, M., Yee, B., Grunstein, R., Phillips, C. (2015). Ethics, consent and blinding: lessons from a placebo/sham controlled CPAP crossover trial. Thorax, 70(3), 265-269. [More Information]
  • Wang, D., Bai, X., Williams, S., Hua, S., Kim, J., Marshall, N., D'Rozario, A., Grunstein, R. (2015). Modafinil Increases Awake EEG Activation and Improves Performance in Obstructive Sleep Apnea During Continuous Positive Airway Pressure Withdrawal. Sleep, 38(8), 1297-1303. [More Information]
  • Gamble, A., D'Rozario, A., Bartlett, D., Williams, S., Bin, Y., Grunstein, R., Marshall, N. (2014). Adolescent sleep patterns and night-time technology use: results of the Australian Broadcasting Corporation's Big Sleep Survey. PloS One, 9(11), 1-9. [More Information]
  • Wang, D., Piper, A., Yee, B., Wong, K., Kim, J., D'Rozario, A., Rowsell, L., Dijk, D., Grunstein, R. (2014). Hypercapnia is a Key Correlate of EEG Activation and Daytime Sleepiness in Hypercapnic Sleep Disordered Breathing Patients. The Journal of Clinical Sleep Medicine, 10(5), 517-522. [More Information]
  • D'Rozario, A., Kim, J., Wong, K., Bartlett, D., Marshall, N., Dijk, D., Robinson, P., Grunstein, R. (2013). A new EEG biomarker of neurobehavioural impairment and sleepiness in sleep apnea patients and controls during extended wakefulness. Clinical Neurophysiology, 124(8), 1605-1614. [More Information]
  • Vakulin, A., D'Rozario, A., Grunstein, R. (2012). Driving Impairment and Accident Risk in Sleep Apnea: We Need Better Assessment Tools. Journal of Sleep Disorders : Treatment & Care, 1(1), 1.00E+105-1.00E+105. [More Information]
  • D'Rozario, A., Wong, K., Dungan, G., Gilholme, J., Marshall, N., Grunstein, R. (2012). Residual sleep-disordered breathing during autotitrating continuous positive airway pressure therapy. European Respiratory Journal, 39(6), 1391-1397. [More Information]
  • Rae, C., Bartlett, D., Yang, Q., Walton, D., D'Rozario, A., Sachinwalla, T., Grunstein, R. (2009). Dynamic changes in brain bioenergetics during obstructive sleep apnea. Journal of Cerebral Blood Flow and Metabolism, 29(8), 1421-1428. [More Information]

Conferences

  • Miller, C., Bartlett, D., Mullins, A., Dodds, K., Gordon, C., Kyle, S., Kim, J., D'Rozario, A., Marshall, N., Yee, B., Grunstein, R., et al (2016). Phenotypes of insomnia disorder built from cluster analysis of objective sleep parameters reveal differences in neurocognitive functioning, quantitative EEG, and heart rate variability. SLEEP, the 30th Annual Meeting of the Associated Professional Sleep Societies LLC (APSS) 2016, USA: The American Academy of Sleep Medicine.
  • Arciuli, J., Vakulin, A., D'Rozario, A., Openshaw, H., Stevens, D., McEvoy, D., Wong, K., Rae, C., Grunstein, R. (2015). Is statistical learning affected by sleep apnea? EuroAsianPacific Joint Conference on Cognitive Science, Torino, Italy: CEUR-WS.
  • Gordon, C., Harrowell, L., Openshaw, H., Marshall, N., Mullins, A., D'Rozario, A., Kim, J., Grunstein, R., Vakulin, A. (2013). Thermoregulatory Responses in Obstructive Sleep Apnea Patients During Simulated Driving Across Extended Wakefulness. Sleep DownUnder 2013, River of Dreams, 25th ASM of Australasian Sleep Association and Australasian Sleep Technologists Association, Tokyo, Japan: The Japanese Society of sleep Research.

2017

  • Miller, C., Rae, C., Green, M., Yee, B., Gordon, C., D'Rozario, A., Kyle, S., Espie, C., Grunstein, R., Bartlett, D. (2017). An Objective Short Sleep Insomnia Disorder Subtype Is Associated With Reduced Brain Metabolite Concentrations In Vivo: A Preliminary Magnetic Resonance Spectroscopy Assessment. Sleep. [More Information]
  • Zobaer, M., Anderson, R., Kerr, C., Robinson, P., Wong, K., D'Rozario, A. (2017). K-complexes, spindles, and ERPs as impulse responses: unification via neural field theory. Biological Cybernetics, 111(2), 149-164. [More Information]
  • Szentkiralyi, A., Wong, K., Grunstein, R., D'Rozario, A., Kim, J. (2017). Performance of an automated algorithm to process artefacts for quantitative EEG analysis during a simultaneous driving simulator performance task. International Journal of Psychophysiology, 121, 12-17. [More Information]

2016

  • Miller, C., Bartlett, D., Mullins, A., Dodds, K., Gordon, C., Kyle, S., Kim, J., D'Rozario, A., Lee, R., Comas, M., Marshall, N., Yee, B., Grunstein, R., et al (2016). Clusters of Insomnia Disorder: An Exploratory Cluster Analysis of Objective Sleep Parameters Reveals Differences in Neurocognitive Functioning, Quantitative EEG, and Heart Rate Variability. Sleep, 39(11), 1993-2004. [More Information]
  • Miller, C., Bartlett, D., Mullins, A., Dodds, K., Gordon, C., Kyle, S., Kim, J., D'Rozario, A., Marshall, N., Yee, B., Grunstein, R., et al (2016). Phenotypes of insomnia disorder built from cluster analysis of objective sleep parameters reveal differences in neurocognitive functioning, quantitative EEG, and heart rate variability. SLEEP, the 30th Annual Meeting of the Associated Professional Sleep Societies LLC (APSS) 2016, USA: The American Academy of Sleep Medicine.
  • Vakulin, A., D'Rozario, A., Kim, J., Watson, B., Cross, N., Wang, D., Coeytaux Jackson, A., Bartlett, D., Wong, K., Grunstein, R. (2016). Quantitative sleep EEG and polysomnographic predictors of driving simulator performance in obstructive sleep apnea. Clinical Neurophysiology, 127(2), 1428-1435. [More Information]

2015

  • Miller, C., Gordon, C., Toubia, L., Bartlett, D., Grunstein, R., D'Rozario, A., Marshall, N. (2015). Agreement between simple questions about sleep duration and sleep diaries in a large online survey. Sleep Health, 1(2), 133-137. [More Information]
  • D'Rozario, A., Dungan, G., Banks, S., Liu, P., Wong, K., Killick, R., Grunstein, R., Kim, J. (2015). An automated algorithm to identify and reject artefacts for quantitative EEG analysis during sleep in patients with sleep-disordered breathing. Sleep and Breathing, 19(2), 607-615. [More Information]
  • Serinel, Y., Marshall, N., D'Rozario, A., Crawford, M., Yee, B., Grunstein, R., Phillips, C. (2015). Ethics, consent and blinding: lessons from a placebo/sham controlled CPAP crossover trial. Thorax, 70(3), 265-269. [More Information]
  • Arciuli, J., Vakulin, A., D'Rozario, A., Openshaw, H., Stevens, D., McEvoy, D., Wong, K., Rae, C., Grunstein, R. (2015). Is statistical learning affected by sleep apnea? EuroAsianPacific Joint Conference on Cognitive Science, Torino, Italy: CEUR-WS.
  • Wang, D., Bai, X., Williams, S., Hua, S., Kim, J., Marshall, N., D'Rozario, A., Grunstein, R. (2015). Modafinil Increases Awake EEG Activation and Improves Performance in Obstructive Sleep Apnea During Continuous Positive Airway Pressure Withdrawal. Sleep, 38(8), 1297-1303. [More Information]

2014

  • Gamble, A., D'Rozario, A., Bartlett, D., Williams, S., Bin, Y., Grunstein, R., Marshall, N. (2014). Adolescent sleep patterns and night-time technology use: results of the Australian Broadcasting Corporation's Big Sleep Survey. PloS One, 9(11), 1-9. [More Information]
  • Wang, D., Piper, A., Yee, B., Wong, K., Kim, J., D'Rozario, A., Rowsell, L., Dijk, D., Grunstein, R. (2014). Hypercapnia is a Key Correlate of EEG Activation and Daytime Sleepiness in Hypercapnic Sleep Disordered Breathing Patients. The Journal of Clinical Sleep Medicine, 10(5), 517-522. [More Information]

2013

  • D'Rozario, A., Kim, J., Wong, K., Bartlett, D., Marshall, N., Dijk, D., Robinson, P., Grunstein, R. (2013). A new EEG biomarker of neurobehavioural impairment and sleepiness in sleep apnea patients and controls during extended wakefulness. Clinical Neurophysiology, 124(8), 1605-1614. [More Information]
  • Gordon, C., Harrowell, L., Openshaw, H., Marshall, N., Mullins, A., D'Rozario, A., Kim, J., Grunstein, R., Vakulin, A. (2013). Thermoregulatory Responses in Obstructive Sleep Apnea Patients During Simulated Driving Across Extended Wakefulness. Sleep DownUnder 2013, River of Dreams, 25th ASM of Australasian Sleep Association and Australasian Sleep Technologists Association, Tokyo, Japan: The Japanese Society of sleep Research.

2012

  • Vakulin, A., D'Rozario, A., Grunstein, R. (2012). Driving Impairment and Accident Risk in Sleep Apnea: We Need Better Assessment Tools. Journal of Sleep Disorders : Treatment & Care, 1(1), 1.00E+105-1.00E+105. [More Information]
  • D'Rozario, A., Wong, K., Dungan, G., Gilholme, J., Marshall, N., Grunstein, R. (2012). Residual sleep-disordered breathing during autotitrating continuous positive airway pressure therapy. European Respiratory Journal, 39(6), 1391-1397. [More Information]

2009

  • Rae, C., Bartlett, D., Yang, Q., Walton, D., D'Rozario, A., Sachinwalla, T., Grunstein, R. (2009). Dynamic changes in brain bioenergetics during obstructive sleep apnea. Journal of Cerebral Blood Flow and Metabolism, 29(8), 1421-1428. [More Information]

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