Dr Kim Bell-Anderson

Senior Lecturer

G08 - Biochemistry and Microbiology Building
The University of Sydney

Telephone +61 2 9351 6267
Fax +61 2 9361 6022

Biographical details

Obesity is fast becoming one of the most important public health problems. With now 1 billion people affected worldwide, this has increased the prevalence of the Metabolic Syndrome, risk of cardiovascular disease (CVD) and type 2 diabetes.

Treating obesity is a real challenge in an environment with increased consumption of unhealthy, calorific foods and reduced need for physical activity. However, unraveling the molecular mechanisms underlying the accumulation of adipose tissue will aid in the identification of targets to reduce fat mass. It is now becoming apparent that adipose tissue, once thought to be a passive storehouse for fat, is a metabolically active organ capable of regulating whole body energy balance. This may be in part mediated by its obvious role in lipid metabolism and insulin sensitivity, but also by numerous secreted adipose tissue factors, adipokines, which have recently been revealed as key players in metabolic function.

My research aims to gain greater understanding of the link between adiposity and metabolic disease, utilizing various techniques including in vivo metabolic testing of small laboratory animals, clinical biochemistry, and protein/gene expression analysis.

Research interests

Obesity is fast becoming one of the most important public health problems. With now 1 billion people affected worldwide, this has increased the prevalence of the Metabolic Syndrome, risk of cardiovascular disease (CVD) and type 2 diabetes.

Treating obesity is a real challenge in an environment with increased consumption of unhealthy, calorific foods and reduced need for physical activity. However, unraveling the molecular mechanisms underlying the accumulation of adipose tissue will aid in the identification of targets to reduce fat mass. It is now becoming apparent that adipose tissue, once thought to be a passive storehouse for fat, is a metabolically active organ capable of regulating whole body energy balance. This may be in part mediated by its obvious role in lipid metabolism and insulin sensitivity, but also by numerous secreted adipose tissue factors, adipokines, which have recently been revealed as key players in metabolic function. My research aims to gain greater understanding of the link between adiposity and metabolic disease, utilizing various techniques including in vivo metabolic testing of small laboratory animals, clinical biochemistry, and protein/gene expression analysis. Dissecting the role of Kruppel-like factor 3 (KLF3) using knockout mice: Mice lacking a functional KLF3 gene are skinny and resistant to diet-induced obesity and insulin resistance. Through microarray analysis of differential gene expression we are identifying Klf3 target genes and working towards defining the molecular mechanisms underlying their lean phenotype. Acute nutrient regulation of insulin sensitivity: Fat-fed insulin resistant rats can be made insulin sensitive by changing their diet. This occurs within 12 hours and suggests that nutrients can acutely modulate insulin action. The mechanism responsible is not known. We are investigating the role of the gastrointestinal tract, restricted feeding and diet composition on the reversal of this fat-induced insulin resistance in the rat. Future studies will investigate the effect of protein quality on whole body insulin sensitivity in rodents.

Keywords

Diabetes; Obesity & overweight; Physiology; Biochemistry; Nutrition and metabolism

Selected grants

2010

  • Transcriptional control of adipogenesis; Crossley P, Bell-Anderson K; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Role of the Endocannabinoid system in development of fatty liver and insulin resistance; Bell-Anderson K; DVC Research/Brown Fellowships.
  • Applied Biosystems 7500 Fast Real Time PCR system; Campbell I, Crossley P, Brand-Miller J, Caterson I, Hall R, Weiss A, Conigrave A, Mackay J, Matthews J, Sunde M, Gell D, Bell-Anderson K, Nicholas H, Crossett B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2007

  • The regulation of gene expression during adipogenesis; Crossley P, Denyer G, Bell-Anderson K; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • Regulation of gene expression by leptin using microarray analysis; Bell-Anderson K; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Establishment Gifts.

Selected publications

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Book Chapters

  • Samman, S., O'Connor, H., Bell-Anderson, K., Foster, M. (2013). Trace elements and inflammation. In Manohar L Garg and Lisa G Wood (Eds.), Nutrition and Physical Activity in Inflammatory Diseases, (pp. 128-144). Oxfordshire & Boston: CAB international.
  • Bell-Anderson, K. (2008). Food Groups: Eggs Food Groups: Herbs and Spices. In Jim Mann and A Stewart Truswell (Eds.), Essentials of Human Nutrition (2nd Ed.), (pp. 369 & 373-369 & 373). United Kingdom: Oxford University Press.

Journals

  • Funnell, A., Mak, K., Twine, N., Pelka, G., Norton, L., Radziewic, T., Power, M., Wilkins, M., Bell-Anderson, K., Fraser, S., Tam, P., et al (2013). Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Molecular and Cellular Biology, 33(15), 2976-2987. [More Information]
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis, A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]
  • Funnell, A., Norton, L., Mak, K., Burdach, J., Artuz, C., Twine, N., Wilkins, M., Power, C., Hung, T., Perdomo, J., Bell-Anderson, K., Fraser, S., et al (2012). The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo. Molecular and Cellular Biology, 32(16), 3281-3292. [More Information]
  • Bell-Anderson, K., Aouad, L., Williams, H., Sanz, F., Phuyal, J., Larter, C., Farrell, G., Caterson, I. (2011). Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice. International Journal of Obesity. [More Information]
  • Larter, C., Yeh, M., Cheng, J., Williams, J., Brown, S., Dela Pena, A., Bell-Anderson, K., Farrell, G. (2008). Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation. Journal of Gastroenterology and Hepatology, 23(2), 267-275. [More Information]
  • Bell-Anderson, K. (2008). Adipokines: linking obesity and cardiovascular disease. Expert Review of Endocrinology and Metabolism, 3(1), 61-73.
  • Larter, C., Yeh, M., Haigh, W., Williams, J., Brown, S., Bell-Anderson, K., Lee, S., Farrell, G. (2008). Hepatic free fatty acids accumulate in experimental steatohepatitis: role of adaptive pathways. Journal of Hepatology, 48(4), 638-647. [More Information]
  • Larter, C., Yeh, M., Farrell, G., Bell-Anderson, K., Williams, J. (2008). MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes. Journal of Hepatology, 49(2008), 407-416. [More Information]
  • Sue, N., Jack, B., Eaton, S., Pearson, R., Funnell, A., Turner, J., Czolij, R., Denyer, G., Bao, B., Molero-Navajas, J., Bell-Anderson, K., Crossley, P., et al (2008). Targeted disruption of the Basic Kruppel-like Factor (Klf3) gene reveals a role in adipogenesis. Molecular and Cellular Biology, 28(12), 3967-3978. [More Information]
  • Bell-Anderson, K., Samman, S. (2007). Feeding baby: consequences of over-nutrition in utero. Current Opinion in Lipidology, 18(2), 224-226. [More Information]
  • Bell-Anderson, K., Samman, S. (2006). Nutrition and metabolism: race, sex and the metabolic syndrome. Current Opinion in Lipidology, 17(1), 82-84. [More Information]
  • Walker, C., Bryson, J., Bell-Anderson, K., Hancock, D., Denyer, G., Caterson, I. (2005). Insulin determines leptin responses during a glucose challenge in fed and fasted rats. International Journal of Obesity, 29(4), 398-405. [More Information]
  • Bell-Anderson, K., Bryson, J. (2004). Leptin as a Potential Treatment for Obesity: Progress to Date. Treatments in Endocrinology, 3(1), 11-18.

2013

  • Funnell, A., Mak, K., Twine, N., Pelka, G., Norton, L., Radziewic, T., Power, M., Wilkins, M., Bell-Anderson, K., Fraser, S., Tam, P., et al (2013). Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Molecular and Cellular Biology, 33(15), 2976-2987. [More Information]
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis, A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]
  • Samman, S., O'Connor, H., Bell-Anderson, K., Foster, M. (2013). Trace elements and inflammation. In Manohar L Garg and Lisa G Wood (Eds.), Nutrition and Physical Activity in Inflammatory Diseases, (pp. 128-144). Oxfordshire & Boston: CAB international.

2012

  • Funnell, A., Norton, L., Mak, K., Burdach, J., Artuz, C., Twine, N., Wilkins, M., Power, C., Hung, T., Perdomo, J., Bell-Anderson, K., Fraser, S., et al (2012). The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo. Molecular and Cellular Biology, 32(16), 3281-3292. [More Information]

2011

  • Bell-Anderson, K., Aouad, L., Williams, H., Sanz, F., Phuyal, J., Larter, C., Farrell, G., Caterson, I. (2011). Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice. International Journal of Obesity. [More Information]

2008

  • Larter, C., Yeh, M., Cheng, J., Williams, J., Brown, S., Dela Pena, A., Bell-Anderson, K., Farrell, G. (2008). Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation. Journal of Gastroenterology and Hepatology, 23(2), 267-275. [More Information]
  • Bell-Anderson, K. (2008). Adipokines: linking obesity and cardiovascular disease. Expert Review of Endocrinology and Metabolism, 3(1), 61-73.
  • Bell-Anderson, K. (2008). Food Groups: Eggs Food Groups: Herbs and Spices. In Jim Mann and A Stewart Truswell (Eds.), Essentials of Human Nutrition (2nd Ed.), (pp. 369 & 373-369 & 373). United Kingdom: Oxford University Press.
  • Larter, C., Yeh, M., Haigh, W., Williams, J., Brown, S., Bell-Anderson, K., Lee, S., Farrell, G. (2008). Hepatic free fatty acids accumulate in experimental steatohepatitis: role of adaptive pathways. Journal of Hepatology, 48(4), 638-647. [More Information]
  • Larter, C., Yeh, M., Farrell, G., Bell-Anderson, K., Williams, J. (2008). MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes. Journal of Hepatology, 49(2008), 407-416. [More Information]
  • Sue, N., Jack, B., Eaton, S., Pearson, R., Funnell, A., Turner, J., Czolij, R., Denyer, G., Bao, B., Molero-Navajas, J., Bell-Anderson, K., Crossley, P., et al (2008). Targeted disruption of the Basic Kruppel-like Factor (Klf3) gene reveals a role in adipogenesis. Molecular and Cellular Biology, 28(12), 3967-3978. [More Information]

2007

  • Bell-Anderson, K., Samman, S. (2007). Feeding baby: consequences of over-nutrition in utero. Current Opinion in Lipidology, 18(2), 224-226. [More Information]

2006

  • Bell-Anderson, K., Samman, S. (2006). Nutrition and metabolism: race, sex and the metabolic syndrome. Current Opinion in Lipidology, 17(1), 82-84. [More Information]

2005

  • Walker, C., Bryson, J., Bell-Anderson, K., Hancock, D., Denyer, G., Caterson, I. (2005). Insulin determines leptin responses during a glucose challenge in fed and fasted rats. International Journal of Obesity, 29(4), 398-405. [More Information]

2004

  • Bell-Anderson, K., Bryson, J. (2004). Leptin as a Potential Treatment for Obesity: Progress to Date. Treatments in Endocrinology, 3(1), 11-18.

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