Dr Kim Bell-Anderson

Senior Lecturer

G08 - Biochemistry and Microbiology Building
The University of Sydney

Telephone +61 2 9351 6267
Fax +61 2 9361 6022

Research interests

Metabolic Phenotyping in Rodents

The emerging Metabolic Phenotyping Facitlity in the Charles Perkins Centre houses essential equipment to precisely measure energy expenditure, feeding behaviour and intake, physical activity, body composition and insulin sensitivity in mice and rats. In vivo physiological testing complemented with large scale proteomics, metabolomics and genomics will be an important systems biology approach to key questions addressing chronic metabolic diseases such as obesity, type 2 diabetes and cardiovascular disease.

Acute nutrient regulation of insulin sensitivity

Fat-fed insulin resistant rats can be made insulin sensitive by changing their diet. This occurs within 12 hours and suggests that nutrients can acutely modulate insulin action. The mechanism responsible is not known. We are investigating the role of the hepatoportal region and diet composition on the reversal of fat-induced insulin resistance in the rat.

Effect of glycemic index on epigenetic regulation and gene expression in offspring

A collaboration with Prof Jennie Brand-Miller and A/Prof Cath Suter (Victor Chang Cardiac Research Institute) investigating the effect of maternal high versus low glycemic index diets on FTO expression and methylation, and IRX3 expression in the hypothalamus, placenta and other tissues of offspring pups (mice).

Measuring energy content by bomb calorimetry

Custodian and operator of a Parr 1356 Isoperibol Bomb Calorimeter. I am very happy to collaborate with researchers requiring measurement of energy content in samples. Recently, I have measured energy content of rodent diets, mouse faeces and seeds.

Teaching and supervision

Course Coordinator NUTM3004 Metabolic Cybernetics

Associations

Chair of the Nutrition Society Australia Sydney Group (since 2011).

Awards and honours

2014 Nutrition Society Australia Mid-career Research Award

In the media

Mutant mice stay skinny on a high fat diet study discovers


6 May 2013http://sydney.edu.au/news/molecular_bioscience/1893.html?newsstoryid=11491

Keywords

Diabetes; Obesity & overweight; Physiology; Biochemistry; Nutrition and metabolism

Selected grants

2015

  • Nutrient regulation of insulin sensitivity; Bell-Anderson K; University of Sydney/SMB Internal Stimulus Grant.

2010

  • Transcriptional control of adipogenesis; Crossley P, Bell-Anderson K; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Role of the Endocannabinoid system in development of fatty liver and insulin resistance; Bell-Anderson K; DVC Research/Brown Fellowships.
  • Applied Biosystems 7500 Fast Real Time PCR system; Campbell I, Crossley P, Brand-Miller J, Caterson I, Hall R, Weiss A, Conigrave A, Mackay J, Matthews J, Sunde M, Gell D, Bell-Anderson K, Nicholas H, Crossett B; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2007

  • The regulation of gene expression during adipogenesis; Crossley P, Denyer G, Bell-Anderson K; National Health and Medical Research Council (NHMRC)/Project Grants.

2002

  • Regulation of gene expression by leptin using microarray analysis; Bell-Anderson K; Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Establishment Gifts.

Selected publications

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Book Chapters

  • Samman, S., O'Connor, H., Bell-Anderson, K., Foster, M. (2013). Trace elements and inflammation. In Manohar L Garg and Lisa G Wood (Eds.), Nutrition and Physical Activity in Inflammatory Diseases, (pp. 128-144). Oxfordshire & Boston: CAB international.
  • Bell-Anderson, K. (2008). Food Groups: Eggs Food Groups: Herbs and Spices. In Jim Mann and A Stewart Truswell (Eds.), Essentials of Human Nutrition (2nd Ed.), (pp. 369 & 373-369 & 373). United Kingdom: Oxford University Press.

Journals

  • Knights, A., Yik, J., Jusoh, H., Norton, L., Funnell, A., Pearson, R., Bell-Anderson, K., Crossley, M., Quinlan, K. (2016). Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3). The Journal of Biological Chemistry, 291(31), 16048-16058. [More Information]
  • Haczeyni, F., Barn, V., Mridha, A., Yeh, M., Estevez, E., Febbraio, M., Nolan, C., Bell-Anderson, K., Teoh, N., Farrell, G. (2015). Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice. Obesity, 23(9), 1845-1855. [More Information]
  • Chu, A., Foster, M., Hancock, D., Bell-Anderson, K., Petocz, P., Samman, S. (2015). TNF-α gene expression is increased following zinc supplementation in type 2 diabetes mellitus. Genes & Nutrition, 10(1), 1-10. [More Information]
  • Knights, A., Funnell, A., Pearson, R., Crossley, M., Bell-Anderson, K. (2014). Adipokines and insulin action: A sensitive issue. Adipocyte, 3(2), 88-96. [More Information]
  • Sullivan, M., Aroney, S., Li, S., Warren, F., Joo, J., Mak, K., Stapleton, D., Bell-Anderson, K., Gilbert, R. (2014). Changes in Glycogen Structure over Feeding Cycle Sheds New Light on Blood-Glucose Control. Biomacromolecules, 15(2), 660-665. [More Information]
  • Liu, M., Montgomery, M., Fiveash, C., Osborne, B., Cooney, G., Bell-Anderson, K., Turner, N. (2014). PPARa-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis. Scientific Reports, 4, 1-9. [More Information]
  • Funnell, A., Mak, K., Twine, N., Pelka, G., Norton, L., Radziewic, T., Power, M., Wilkins, M., Bell-Anderson, K., Fraser, S., Tam, P., et al (2013). Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Molecular and Cellular Biology, 33(15), 2976-2987. [More Information]
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis (nee Sainsbury), A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]
  • Funnell, A., Norton, L., Mak, K., Burdach, J., Artuz, C., Twine, N., Wilkins, M., Power, C., Hung, T., Perdomo, J., Bell-Anderson, K., Fraser, S., et al (2012). The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo. Molecular and Cellular Biology, 32(16), 3281-3292. [More Information]
  • Bell-Anderson, K., Aouad, L., Williams, H., Sanz, F., Phuyal, J., Larter, C., Farrell, G., Caterson, I. (2011). Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice. International Journal of Obesity, 35(12), 1539-1548. [More Information]
  • Larter, C., Yeh, M., Cheng, J., Williams, J., Brown, S., Dela Pena, A., Bell-Anderson, K., Farrell, G. (2008). Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation. Journal of Gastroenterology and Hepatology, 23(2), 267-275. [More Information]
  • Bell-Anderson, K. (2008). Adipokines: linking obesity and cardiovascular disease. Expert Review of Endocrinology & Metabolism, 3(1), 61-73.
  • Larter, C., Yeh, M., Haigh, W., Williams, J., Brown, S., Bell-Anderson, K., Lee, S., Farrell, G. (2008). Hepatic free fatty acids accumulate in experimental steatohepatitis: role of adaptive pathways. Journal of Hepatology, 48(4), 638-647. [More Information]
  • Larter, C., Yeh, M., Farrell, G., Bell-Anderson, K., Williams, J. (2008). MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes. Journal of Hepatology, 49(2008), 407-416. [More Information]
  • Sue, N., Jack, B., Eaton, S., Pearson, R., Funnell, A., Turner, J., Czolij, R., Denyer, G., Bao, B., Molero-Navajas, J., Bell-Anderson, K., Crossley, P., et al (2008). Targeted disruption of the Basic Kruppel-like Factor (Klf3) gene reveals a role in adipogenesis. Molecular and Cellular Biology, 28(12), 3967-3978. [More Information]
  • Bell-Anderson, K., Samman, S. (2007). Feeding baby: consequences of over-nutrition in utero. Current Opinion in Lipidology, 18(2), 224-226. [More Information]
  • Bell-Anderson, K., Samman, S. (2006). Nutrition and metabolism: race, sex and the metabolic syndrome. Current Opinion in Lipidology, 17(1), 82-84. [More Information]
  • Walker, C., Bryson, J., Bell-Anderson, K., Hancock, D., Denyer, G., Caterson, I. (2005). Insulin determines leptin responses during a glucose challenge in fed and fasted rats. International Journal of Obesity, 29(4), 398-405. [More Information]
  • Bell-Anderson, K., Bryson, J. (2004). Leptin as a Potential Treatment for Obesity: Progress to Date. Treatments in Endocrinology, 3(1), 11-18.

2016

  • Knights, A., Yik, J., Jusoh, H., Norton, L., Funnell, A., Pearson, R., Bell-Anderson, K., Crossley, M., Quinlan, K. (2016). Krüppel-like Factor 3 (KLF3/BKLF) Is Required for Widespread Repression of the Inflammatory Modulator Galectin-3 (Lgals3). The Journal of Biological Chemistry, 291(31), 16048-16058. [More Information]

2015

  • Haczeyni, F., Barn, V., Mridha, A., Yeh, M., Estevez, E., Febbraio, M., Nolan, C., Bell-Anderson, K., Teoh, N., Farrell, G. (2015). Exercise improves adipose function and inflammation and ameliorates fatty liver disease in obese diabetic mice. Obesity, 23(9), 1845-1855. [More Information]
  • Chu, A., Foster, M., Hancock, D., Bell-Anderson, K., Petocz, P., Samman, S. (2015). TNF-α gene expression is increased following zinc supplementation in type 2 diabetes mellitus. Genes & Nutrition, 10(1), 1-10. [More Information]

2014

  • Knights, A., Funnell, A., Pearson, R., Crossley, M., Bell-Anderson, K. (2014). Adipokines and insulin action: A sensitive issue. Adipocyte, 3(2), 88-96. [More Information]
  • Sullivan, M., Aroney, S., Li, S., Warren, F., Joo, J., Mak, K., Stapleton, D., Bell-Anderson, K., Gilbert, R. (2014). Changes in Glycogen Structure over Feeding Cycle Sheds New Light on Blood-Glucose Control. Biomacromolecules, 15(2), 660-665. [More Information]
  • Liu, M., Montgomery, M., Fiveash, C., Osborne, B., Cooney, G., Bell-Anderson, K., Turner, N. (2014). PPARa-independent actions of omega-3 PUFAs contribute to their beneficial effects on adiposity and glucose homeostasis. Scientific Reports, 4, 1-9. [More Information]

2013

  • Funnell, A., Mak, K., Twine, N., Pelka, G., Norton, L., Radziewic, T., Power, M., Wilkins, M., Bell-Anderson, K., Fraser, S., Tam, P., et al (2013). Generation of mice deficient in both KLF3/BKLF and KLF8 reveals a genetic interaction and a role for these factors in embryonic globin gene silencing. Molecular and Cellular Biology, 33(15), 2976-2987. [More Information]
  • Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis (nee Sainsbury), A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]
  • Samman, S., O'Connor, H., Bell-Anderson, K., Foster, M. (2013). Trace elements and inflammation. In Manohar L Garg and Lisa G Wood (Eds.), Nutrition and Physical Activity in Inflammatory Diseases, (pp. 128-144). Oxfordshire & Boston: CAB international.

2012

  • Funnell, A., Norton, L., Mak, K., Burdach, J., Artuz, C., Twine, N., Wilkins, M., Power, C., Hung, T., Perdomo, J., Bell-Anderson, K., Fraser, S., et al (2012). The CACCC-Binding Protein KLF3/BKLF Represses a Subset of KLF1/EKLF Target Genes and Is Required for Proper Erythroid Maturation In Vivo. Molecular and Cellular Biology, 32(16), 3281-3292. [More Information]

2011

  • Bell-Anderson, K., Aouad, L., Williams, H., Sanz, F., Phuyal, J., Larter, C., Farrell, G., Caterson, I. (2011). Coordinated improvement in glucose tolerance, liver steatosis and obesity-associated inflammation by cannabinoid 1 receptor antagonism in fat Aussie mice. International Journal of Obesity, 35(12), 1539-1548. [More Information]

2008

  • Larter, C., Yeh, M., Cheng, J., Williams, J., Brown, S., Dela Pena, A., Bell-Anderson, K., Farrell, G. (2008). Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation. Journal of Gastroenterology and Hepatology, 23(2), 267-275. [More Information]
  • Bell-Anderson, K. (2008). Adipokines: linking obesity and cardiovascular disease. Expert Review of Endocrinology & Metabolism, 3(1), 61-73.
  • Bell-Anderson, K. (2008). Food Groups: Eggs Food Groups: Herbs and Spices. In Jim Mann and A Stewart Truswell (Eds.), Essentials of Human Nutrition (2nd Ed.), (pp. 369 & 373-369 & 373). United Kingdom: Oxford University Press.
  • Larter, C., Yeh, M., Haigh, W., Williams, J., Brown, S., Bell-Anderson, K., Lee, S., Farrell, G. (2008). Hepatic free fatty acids accumulate in experimental steatohepatitis: role of adaptive pathways. Journal of Hepatology, 48(4), 638-647. [More Information]
  • Larter, C., Yeh, M., Farrell, G., Bell-Anderson, K., Williams, J. (2008). MCD-induced steatohepatitis is associated with hepatic adiponectin resistance and adipogenic transformation of hepatocytes. Journal of Hepatology, 49(2008), 407-416. [More Information]
  • Sue, N., Jack, B., Eaton, S., Pearson, R., Funnell, A., Turner, J., Czolij, R., Denyer, G., Bao, B., Molero-Navajas, J., Bell-Anderson, K., Crossley, P., et al (2008). Targeted disruption of the Basic Kruppel-like Factor (Klf3) gene reveals a role in adipogenesis. Molecular and Cellular Biology, 28(12), 3967-3978. [More Information]

2007

  • Bell-Anderson, K., Samman, S. (2007). Feeding baby: consequences of over-nutrition in utero. Current Opinion in Lipidology, 18(2), 224-226. [More Information]

2006

  • Bell-Anderson, K., Samman, S. (2006). Nutrition and metabolism: race, sex and the metabolic syndrome. Current Opinion in Lipidology, 17(1), 82-84. [More Information]

2005

  • Walker, C., Bryson, J., Bell-Anderson, K., Hancock, D., Denyer, G., Caterson, I. (2005). Insulin determines leptin responses during a glucose challenge in fed and fasted rats. International Journal of Obesity, 29(4), 398-405. [More Information]

2004

  • Bell-Anderson, K., Bryson, J. (2004). Leptin as a Potential Treatment for Obesity: Progress to Date. Treatments in Endocrinology, 3(1), 11-18.

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