Dr Kimberley Kaufman

BMedSc (Hons), PhD
Cancer Institute NSW Research Fellow
BrainStorm Brain Cancer Research Group at the Brain and Mind Centre
Manager of RPA Neuropathology Tumour and Tissue Bank
RPA Honorary Research Fellow

M02F - 88 Mallett Street - Building F
The University of Sydney

Telephone 9351 0846

Website RPA Neuropathology Department
BrainStorm, Brain Cancer Research Charity

Biographical details

I am an Early Career Research Fellow in the School of Life and Environmental Sciences, USYD and an Honorary Associate of the Neuropathology Department, RPAH. I work with the BrainStorm Brain Cancer Research Group at the Brain and Mind Centre. I have contributed to the field of the clinical proteomics for more than 13 years, conducting some of the first human brain proteome studies in 2004.

Research interests

My research utilises cutting-edge mass spectrometry with novel sample preparation procedures to resolve the molecular landscape of cancer. This information can support important clinical questions, e.g., disease stratification, treatment pre-selection and prognostication as well as identify therapeutic targets and chemo-resistance mechanisms. I am active in biomarker research, resolving novel protein markers by quantitative proteomic strategies using surgical tissues, aspirates and peripheral serums.

Current research students

Project title Research student
Modulation of Neuroglia Function by Glioblastoma Stem Cell-derived Extracellular Vesicles Susannah HALLAL

Associations

Cancer Insitute NSWNeuro-Oncology Advisory Group, 2015 - current

Brain Cancer Biobanking Australia, 2015 - current

Experimental Neuropathology Affinity Group, Sydney Neuroscience Network, 2015 - current

European Association for NeuroOncology, 2014- current

The Australian and New Zealand Society for Neuropathology, 2014 - current

NHMRC Research Translation Faculty, 2012 - current

European Association for Cancer Research, 2012 - current

Australian Proteomics Society, 2010 – current

Cancer Research Network Sydney University, 2009 - current

Tumour Microenvionment Special Interest Group, 2009 - current

Sydney Protein Group, 2008 – current

Awards and honours

Travel grant ($2500) to present at European Association for NeuroOncology meeting in Italy (2014)

Travel award ($3000) to present at Human Proteome Organisation World Congress in Spain (2014)

Award for outstanding abstract, S.Mactier, K.Kaufman et al., “Protein signatures correspond to survival outcomes of AJCC stage III melanoma patients”,Annual Paris Melanoma Conference (2014)

Fellowship travel grant ($2000) to attend the European Cancer Congress, Netherlands (2013)

Poster prize at Australasian Proteomics Symposium, Senior Author (2013)

Australasian Proteomics Society Early Postdoctoral Fellow Travel Award (2010)

Nerve Research Foundation ‘Bannigan Prize for the Best PhD in Neuroscience’ (2008).

Scholarship for internship at Brain Science Institute, RIKEN, Tokyo, Japan. Supervised by Molecular Psychiatrist, Dr Takeo Yoshikawa (2006).

Bercovici Prize for Excellence in Medical Research’ awarded to the postgraduate with the most outstanding publication at the University of Sydney (2006).

Summer Research Scholarship, Schizophrenia Research Institute (2003 – 2004)

I am manager of the RPA Hospital Neurological Tumour and Tissue Bank (NTTB).

Themes

Molecular biology and biotechnology; Genetics and genomics; Human health

Selected grants

2014

  • Mechanisms of tumour recurrence and chemotherapy escape in glioblastoma multiforme; Kaufman (nee Alexander) K; Cancer Institute New South Wales/Early Career Fellowship.

2011

  • Surface Antigen Profiles of NeuralEctoderm Tumors:; Kaufman (nee Alexander) K; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

Selected publications

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Book Chapters

  • Matsumoto, I., Kaufman (nee Alexander), K., Matsuda-Matsumoto, H., Kashem, M., Harper, C. (2008). Ethanol-Related Encephalopathies. In GianPietro Sechi (Eds.), Drug related Encephalopathies, (pp. 147-181). New York: Nova Science Publishers.

Journals

  • Mallawaaratchy, D., Hallal, S., Russell, B., Ly, L., Ebrahimkhani, S., Wei, H., Christopherson, R., Buckland, M., Kaufman (nee Alexander), K. (2017). Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. Journal of Neuro-Oncology, 131(2), 233-244. [More Information]
  • Azimi, A., Kaufman (nee Alexander), K., Ali, M., Kossard, S., Fernandez Penas, P. (2016). In Silico Analysis Validates Proteomic Findings of Formalin-fixed Paraffin Embedded Cutaneous Squamous Cell Carcinoma Tissue. Cancer Genomics & Proteomics, 13(6), 453-466. [More Information]
  • Huang, P., Mactier, S., Armacki, N., Best, O., Belov, L., Kaufman (nee Alexander), K., Pascovici, D., Mulligan, S., Christopherson, R. (2016). Protein profiles distinguish stable and progressive chronic lymphocytic leukemia. Leukemia & Lymphoma, 57(5), 1033-1043. [More Information]
  • Mallawaaratchy, D., Buckland, M., McDonald, K., Li, C., Ly, L., Sykes, E., Christopherson, R., Kaufman (nee Alexander), K. (2015). Membrane proteome analysis of glioblastoma cell invasion. Journal of Neuropathology and Experimental Neurology, 74(5), 425-441. [More Information]
  • Hare, N., Chan, B., Chan, E., Kaufman (nee Alexander), K., Britton, W., Saunders, B. (2015). Microparticles released from Mycobacterium tuberculosis-infected human macrophages contain increased levels of the type I interferon inducible proteins including ISG15. Proteomics, 15(17), 3020-3029. [More Information]
  • Wilcox, P., Li, C., Lee, M., Shivalingam, B., Brennan, J., Suter, C., Kaufman, K., Lum, T., Buckland, M. (2015). Oligoastrocytomas: throwing the baby out with the bathwater? Acta Neuropathologica, 129(1), 147-149. [More Information]
  • Zhou, J., Belov, L., Chapuis, P., Chan, C., Armstrong, N., Kaufman (nee Alexander), K., Solomon, M., Clarke, S., Christopherson, R. (2015). Surface profiles of live colorectal cancer cells and tumor infiltrating lymphocytes from surgical samples correspond to prognostic categories. Journal of Immunological Methods, 416, 59-68. [More Information]
  • Kaufman, K., Jenkins, Y., Alomari, M., Mirzaei, M., Best, O., Pascovici, D., Mactier, S., Mulligan, S., Haynes, P., Christopherson, R. (2015). The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia. Oncotarget, 6(38), 40981-40997. [More Information]
  • Alomari, M., Mactier, S., Kaufman (nee Alexander), K., Best, O., Mulligan, S., Christopherson, R. (2014). Profiling the lipid raft proteome from human MEC1 chronic lymphocytic Leukemia Cells. Journal of Proteomics & Bioinformatics, S7, 005. [More Information]
  • Mactier, S., Kaufman (nee Alexander), K., Wang, P., Crossett, B., Pupo, G., Kohnke, P., Thompson, J., Scolyer, R., Yang, J., Mann, G., Christopherson, R. (2014). Protein signatures correspond to survival outcomes of AJCC stage III melanoma patients. Pigment Cell & Melanoma Research, 27(6), 1106-1116. [More Information]
  • Kaufman (nee Alexander), K., Mactier, S., Armstrong, N., Mallawaaratchy, D., Byrne, S., Haydu, L., Jakrot, V., Thompson, J., Mann, G., Scolyer, R., Christopherson, R. (2014). Surface antigen profiles of leukocytes and melanoma cells in lymph node metastases are associated with survival in AJCC stage III melanoma patients. Clinical and Experimental Metastasis, 31, 407-421. [More Information]
  • Che, Y., Best, G., Zhong, L., Kaufman (nee Alexander), K., Mactier, S., Raftery, M., Graves, L., Mulligan, S., Christopherson, R. (2013). Hsp90 Inhibitor SNX-7081 Dysregulates Proteins Involved with DNA Repair and Replication and the Cell Cycle in Human Chronic Lymphocytic Leukemia (CLL) Cells. Journal of Proteome Research, 12(4), 1710-1722. [More Information]
  • Mallawaaratchy, D., Mactier, S., Kaufman (nee Alexander), K., Blomfield, S., Christopherson, R. (2012). The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells. Journal of Proteomics, 75(5), 1590-1599. [More Information]
  • Heath, E., Kaufman (nee Alexander), K., Christopherson, R. (2011). B-RAF: A Contributor to the Melanoma Phenotype. The International Journal of Biochemistry and Cell Biology, 43(1), 29-32. [More Information]
  • Zahr, N., Kaufman (nee Alexander), K., Harper, C. (2011). Clinical and pathological features of alcohol-related brain damage. Nature Reviews. Neurology, 7(5), 284-294. [More Information]
  • Kaufman (nee Alexander), K., Belov, L., Huang, P., Mactier, S., Scolyer, R., Mann, G., Christopherson, R. (2010). An extended antibody microarray for surface profiling metastatic melanoma. Journal of Immunological Methods, 358(40210 (1-2)), 23-34. [More Information]
  • Kaufman (nee Alexander), K., Harper, C. (2009). Transketolase: Observations in alcohol-related brain damage research. The International Journal of Biochemistry and Cell Biology, 41(4), 717-720. [More Information]
  • Kaufman (nee Alexander), K., Cordwell, S., Harper, C., Matsumoto, I. (2007). A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. Proteomics - Clinical Applications, 1(1), 62-72. [More Information]
  • Kaufman (nee Alexander), K., Harper, C., Wilce, P., Matsumoto, I. (2007). Cerebellar Vermis Proteome of Chronic Alcoholic Individuals. Alcoholism: Clinical and Experimental Research, 31(8), 1286-1296. [More Information]
  • Matsumoto, I., Kaufman (nee Alexander), K., Iwazaki, T., Kashem, M., Matsuda-Matsumoto, H. (2007). CNS proteomes in alcohol and drug abuse and dependence. Expert Review of Proteomics, 4(4), 539-552. [More Information]
  • Kaufman (nee Alexander), K., Dedova, I., Harper, C., Matsumoto, I. (2007). Proteome analysis of the dorsolateral prefrontal region from healthy individuals. Neurochemistry International, 51(6-7), 433-439. [More Information]
  • Matsumoto, I., Kaufman (nee Alexander), K., Harper, C. (2006). Alcohol-induced brain damage: Proteomics on postmortem human brain. Alcoholism: Clinical and Experimental Research, 30(Sup.2), 85A-85A.
  • Kaufman (nee Alexander), K., James, G., Sheedy, D., Harper, C., Matsumoto, I. (2006). Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study. Molecular Psychiatry, 11(1), 56-65. [More Information]

Conferences

  • Kaufman (nee Alexander), K., Harper, C., Matsumoto, I. (2006). A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
  • Matsumoto, I., Kaufman (nee Alexander), K. (2006). Alcohol-specific cascades underlying alcohol-induced prefrontal cortex damage: Insight proteomics studies. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.

2017

  • Mallawaaratchy, D., Hallal, S., Russell, B., Ly, L., Ebrahimkhani, S., Wei, H., Christopherson, R., Buckland, M., Kaufman (nee Alexander), K. (2017). Comprehensive proteome profiling of glioblastoma-derived extracellular vesicles identifies markers for more aggressive disease. Journal of Neuro-Oncology, 131(2), 233-244. [More Information]

2016

  • Azimi, A., Kaufman (nee Alexander), K., Ali, M., Kossard, S., Fernandez Penas, P. (2016). In Silico Analysis Validates Proteomic Findings of Formalin-fixed Paraffin Embedded Cutaneous Squamous Cell Carcinoma Tissue. Cancer Genomics & Proteomics, 13(6), 453-466. [More Information]
  • Huang, P., Mactier, S., Armacki, N., Best, O., Belov, L., Kaufman (nee Alexander), K., Pascovici, D., Mulligan, S., Christopherson, R. (2016). Protein profiles distinguish stable and progressive chronic lymphocytic leukemia. Leukemia & Lymphoma, 57(5), 1033-1043. [More Information]

2015

  • Mallawaaratchy, D., Buckland, M., McDonald, K., Li, C., Ly, L., Sykes, E., Christopherson, R., Kaufman (nee Alexander), K. (2015). Membrane proteome analysis of glioblastoma cell invasion. Journal of Neuropathology and Experimental Neurology, 74(5), 425-441. [More Information]
  • Hare, N., Chan, B., Chan, E., Kaufman (nee Alexander), K., Britton, W., Saunders, B. (2015). Microparticles released from Mycobacterium tuberculosis-infected human macrophages contain increased levels of the type I interferon inducible proteins including ISG15. Proteomics, 15(17), 3020-3029. [More Information]
  • Wilcox, P., Li, C., Lee, M., Shivalingam, B., Brennan, J., Suter, C., Kaufman, K., Lum, T., Buckland, M. (2015). Oligoastrocytomas: throwing the baby out with the bathwater? Acta Neuropathologica, 129(1), 147-149. [More Information]
  • Zhou, J., Belov, L., Chapuis, P., Chan, C., Armstrong, N., Kaufman (nee Alexander), K., Solomon, M., Clarke, S., Christopherson, R. (2015). Surface profiles of live colorectal cancer cells and tumor infiltrating lymphocytes from surgical samples correspond to prognostic categories. Journal of Immunological Methods, 416, 59-68. [More Information]
  • Kaufman, K., Jenkins, Y., Alomari, M., Mirzaei, M., Best, O., Pascovici, D., Mactier, S., Mulligan, S., Haynes, P., Christopherson, R. (2015). The Hsp90 inhibitor SNX-7081 is synergistic with fludarabine nucleoside via DNA damage and repair mechanisms in human, p53-negative chronic lymphocytic leukemia. Oncotarget, 6(38), 40981-40997. [More Information]

2014

  • Alomari, M., Mactier, S., Kaufman (nee Alexander), K., Best, O., Mulligan, S., Christopherson, R. (2014). Profiling the lipid raft proteome from human MEC1 chronic lymphocytic Leukemia Cells. Journal of Proteomics & Bioinformatics, S7, 005. [More Information]
  • Mactier, S., Kaufman (nee Alexander), K., Wang, P., Crossett, B., Pupo, G., Kohnke, P., Thompson, J., Scolyer, R., Yang, J., Mann, G., Christopherson, R. (2014). Protein signatures correspond to survival outcomes of AJCC stage III melanoma patients. Pigment Cell & Melanoma Research, 27(6), 1106-1116. [More Information]
  • Kaufman (nee Alexander), K., Mactier, S., Armstrong, N., Mallawaaratchy, D., Byrne, S., Haydu, L., Jakrot, V., Thompson, J., Mann, G., Scolyer, R., Christopherson, R. (2014). Surface antigen profiles of leukocytes and melanoma cells in lymph node metastases are associated with survival in AJCC stage III melanoma patients. Clinical and Experimental Metastasis, 31, 407-421. [More Information]

2013

  • Che, Y., Best, G., Zhong, L., Kaufman (nee Alexander), K., Mactier, S., Raftery, M., Graves, L., Mulligan, S., Christopherson, R. (2013). Hsp90 Inhibitor SNX-7081 Dysregulates Proteins Involved with DNA Repair and Replication and the Cell Cycle in Human Chronic Lymphocytic Leukemia (CLL) Cells. Journal of Proteome Research, 12(4), 1710-1722. [More Information]

2012

  • Mallawaaratchy, D., Mactier, S., Kaufman (nee Alexander), K., Blomfield, S., Christopherson, R. (2012). The phosphoinositide 3-kinase inhibitor LY294002, decreases aminoacyl-tRNA synthetases, chaperones and glycolytic enzymes in human HT-29 colorectal cancer cells. Journal of Proteomics, 75(5), 1590-1599. [More Information]

2011

  • Heath, E., Kaufman (nee Alexander), K., Christopherson, R. (2011). B-RAF: A Contributor to the Melanoma Phenotype. The International Journal of Biochemistry and Cell Biology, 43(1), 29-32. [More Information]
  • Zahr, N., Kaufman (nee Alexander), K., Harper, C. (2011). Clinical and pathological features of alcohol-related brain damage. Nature Reviews. Neurology, 7(5), 284-294. [More Information]

2010

  • Kaufman (nee Alexander), K., Belov, L., Huang, P., Mactier, S., Scolyer, R., Mann, G., Christopherson, R. (2010). An extended antibody microarray for surface profiling metastatic melanoma. Journal of Immunological Methods, 358(40210 (1-2)), 23-34. [More Information]

2009

  • Kaufman (nee Alexander), K., Harper, C. (2009). Transketolase: Observations in alcohol-related brain damage research. The International Journal of Biochemistry and Cell Biology, 41(4), 717-720. [More Information]

2008

  • Matsumoto, I., Kaufman (nee Alexander), K., Matsuda-Matsumoto, H., Kashem, M., Harper, C. (2008). Ethanol-Related Encephalopathies. In GianPietro Sechi (Eds.), Drug related Encephalopathies, (pp. 147-181). New York: Nova Science Publishers.

2007

  • Kaufman (nee Alexander), K., Cordwell, S., Harper, C., Matsumoto, I. (2007). A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. Proteomics - Clinical Applications, 1(1), 62-72. [More Information]
  • Kaufman (nee Alexander), K., Harper, C., Wilce, P., Matsumoto, I. (2007). Cerebellar Vermis Proteome of Chronic Alcoholic Individuals. Alcoholism: Clinical and Experimental Research, 31(8), 1286-1296. [More Information]
  • Matsumoto, I., Kaufman (nee Alexander), K., Iwazaki, T., Kashem, M., Matsuda-Matsumoto, H. (2007). CNS proteomes in alcohol and drug abuse and dependence. Expert Review of Proteomics, 4(4), 539-552. [More Information]
  • Kaufman (nee Alexander), K., Dedova, I., Harper, C., Matsumoto, I. (2007). Proteome analysis of the dorsolateral prefrontal region from healthy individuals. Neurochemistry International, 51(6-7), 433-439. [More Information]

2006

  • Kaufman (nee Alexander), K., Harper, C., Matsumoto, I. (2006). A proteome analysis of the dorsolateral prefrontal cortex in human alcoholic patients. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
  • Matsumoto, I., Kaufman (nee Alexander), K., Harper, C. (2006). Alcohol-induced brain damage: Proteomics on postmortem human brain. Alcoholism: Clinical and Experimental Research, 30(Sup.2), 85A-85A.
  • Matsumoto, I., Kaufman (nee Alexander), K. (2006). Alcohol-specific cascades underlying alcohol-induced prefrontal cortex damage: Insight proteomics studies. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
  • Kaufman (nee Alexander), K., James, G., Sheedy, D., Harper, C., Matsumoto, I. (2006). Differential protein expression in the prefrontal white matter of human alcoholics: a proteomics study. Molecular Psychiatry, 11(1), 56-65. [More Information]

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