Dr Michael Bowen

A16 - Badham Building
The University of Sydney


Research interests

My research uses cutting-edge cellular and preclinical research techniques to discover and develop novel pharmacotherapies for serious brain disorders that currently lack effective treatments. Some of my most important work involves the discovery and development of novel pharmacological treatments targeting the brain oxytocin system that are aimed at substance-use disorders and social disorders, such as autism spectrum disorder. In other ongoing work, I am exploring the utility of targeting extrasynaptic GABAA receptors to treat a number of neurological and mental health disorders. More recently, I have joined the Lambert Initiative for Cannabinoid Therapeutics as the Research Coordinator and have begun exploring the therapeutical potential of novel phytocannabinoids for a number of disorders, including anxiety disorders and epilepsy.

Awards and honours

2016 Finalist (top 3) for the Eureka Prize for Outstanding Early Career Researcher (winner TBA August 31st 2016)

2016 International Behavioral Neuroscience Society Early Career Award

2016 Invited into The World Economic Forum’s Young Scientist Community

2016 Invited to give the Occasional Address at University of Sydney Graduation Ceremony (7thApril 2016)

2015 Early Career Researcher of the Year - NSW Premier’s Prizes for Science and Engineering

2015 Rita and John Cornforth Medal for PhD Achievement, University of Sydney Alumni Awards

2015 Australian Psychological Society Award for Excellent PhD Thesis in Psychology

2015 Finalist (top 3) for the Awards Australia Young Achiever Awards Science Leadership Award

2015 H. Tasman Lovell Medal for best PhD Thesis awarded in the School of Psychology, University of Sydney

2015 Bowen et al (2015) PNAS paper featured as the Editor’s Choice in the high impact journal Science Signaling

2014 Postdoctoral Travel Award - IBNS meeting 2014, Las Vegas, Nevada, USA

2014 Postgraduate Publication Prize - School of Psychology, University of Sydney

2013 Glenn I. Hatton Memorial Award from the International Neuroendocrine Federation

2012 Graduate Student Travel Award - IBNS meeting 2012, Kona, Hawaii, USA

2012 Postgraduate Publication Prize - School of Psychology, University of Sydney

2011 Young Investigator Award – 9th World Congress on Neurohypophysial Hormones, Boston, USA

2011 Best poster prize – Sydney Mental Health and Neuroscience Theme Conference

2011 Finalist – Sydney University Three Minute Thesis competition

2011 Campbell Perry International Research Award – School of Psychology, University of Sydney

Patents

1. International Patent Application (PCT filed July 2016, CDIP ref #2015-038-PCT-0). Bowen MT, McGregor IS, Kassiou M, Hicks C, Jorgensen W. Therapeutic compounds and compositions for treating social disorders and substance use disorders.

2. Australian Provisional Patent Application 2015902659 (Filed 2015). Bowen MT, McGregor IS, Kassiou M, Hicks C, Jorgensen W. Therapeutic compounds and compositions for treating social disorders and substance use disorders.

3. USA Patent US9119805B2 (Granted 2015). Bowen MT, McGregor IS, Carson DS, Guastella A. Granted. Therapy and Prevention of Problem Drinking.

4. Australian Patent 2010302945 (Granted 2015). Bowen MT, McGregor IS, Carson DS, Guastella A. Granted. Therapy and Prevention of Problem Drinking.

5. European Patent EP2482835B1 (Granted 2014). Bowen MT, McGregor IS, Carson DS, Guastella A. Granted. Therapy and Prevention of Problem Drinking.

Selected grants

2016

  • Clever Sys Inc. SocialScan Suite software and hardware package for automated detection and quantification of complex rodent social behaviours; Bowen M, McGregor I, Dadds M, Hawes D; School of Psychology/Top-Slice funding under RIBG.
  • Oxytocin as a novel antagonist of the intoxicating and addictive effects of alcohol; Neumann I, McGregor I, Clarkson A, Collins M, Bowen M; National Health and Medical Research Council (NHMRC)/Project Grants.

2015

  • From ‘BIG DATA’ to evidence: Post-market surveillance of psychotropic medicines in Australia; Schneider C, Pearson S, Karanges E, McGregor I, Buckley N, McLachlan A, Wilson F, Marshall N, Hunt G, Allsop D, Bowen M, Hunt C, Russell J, Abbott M, Lintzeris N; DVC Research/HMR+ Implementation Fund - University.
  • A Mouse Biotelemetry System for Stroke, Epilepsy and Sleep Research; McGregor I, Collins M, Grunstein R, Kassiou M, Bowen M; DVC Research/Equipment Grant.
  • Preclinical assessment of the potential utility of oxytocin and a novel oxytocin agonist for the treatment of substance use disorders and social dysfunction; Bowen M; National Health and Medical Research Council (NHMRC)/Early Career Fellowships.

Selected publications

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Book Chapters

  • Bowen, M., Liu, J., Buisman-Pijlman, F. (2016). Oxytocin: Providing New Avenues for Treating and Understanding Problematic Drug Use. In Victor R. Preedy (Eds.), Neuropathology of Drug Addictions and Substance Misuse - Volume 1: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids, (pp. 82-92). London: Academic Press. [More Information]
  • Bowen, M. (2014). Miscellaneous Hormones. In Sidhartha D. Ray (Eds.), Side Effects of Drugs Annual: A worldwide yearly survey of new data in adverse drug reactions, (pp. 659-673). Amsterdam, Netherlands: Elsevier. [More Information]
  • McGregor, I., Bowen, M. (2013). Oxytocin and addiction: recent preclinical advances and future clinical potential. In E. Choleris, D. W. Pfaff, & M. Kavaliers (Eds.), Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior, (pp. 270-287). Cambridge, UK: Cambridge University Press.

Journals

  • Peters, S., Bowen, M., Bohrer, K., McGregor, I., Neumann, I. (2016). Oxytocin inhibits ethanol consumption and ethanol induced dopamine release in the nucleus accumbens. Addiction Biology, In press. [More Information]
  • Bowen, M., Peters, S., Absalom, N., Chebib, M., Neumann, I., McGregor, I. (2015). Oxytocin prevents ethanol actions at δ subunitcontaining GABAA receptors and attenuates ethanolinduced motor impairment in rats. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 112(10), 3104-3109. [More Information]
  • Bowen, M., Hari Dass, S., Booth, J., Suraev, A., Vyas, A., McGregor, I. (2014). Active coping toward predatory stress is associated with lower corticosterone and progesterone plasma levels and decreased methylation in the medial amygdala vasopressin system. Hormones and Behavior, 66(3), 561-566. [More Information]
  • Suraev, A., Bowen, M., Ali, S., Hicks, C., Ramos, L., McGregor, I. (2014). Adolescent exposure to oxytocin, but not the selective oxytocin receptor agonist TGOT, increases social behavior and plasma oxytocin in adulthood. Hormones and Behavior, 65(5), 488-496. [More Information]
  • Bowen, M., McGregor, I. (2014). Oxytocin and vasopressin modulate the social response to threat: a preclinical study. International Journal of Neuropsychopharmacology, 17, 1621-1633. [More Information]
  • Bowen, M., Kevin, R., May, M., Staples, L., Hunt, G., McGregor, I. (2013). Defensive Aggregation (Huddling) in Rattus Norvegicus toward Predator Odor: Individual Differences, Social Buffering Effects and Neural Correlates. PloS One, 8(7), 1-15. [More Information]
  • Motbey, C., Clemens, K., Apetz, N., Winstock, A., Ramsey, J., Li, K., Wyatt, N., Callaghan, P., Bowen, M., Cornish, J., McGregor, I. (2013). High levels of intravenous mephedrone (4-methylmethcathinone) self-administration in rats: Neural consequences and comparison with methamphetamine. Journal of Psychopharmacology, 27(9), 823-836. [More Information]
  • Bowen, M., Keats, K., Kendig, M., Cakic, V., Callaghan, P., McGregor, I. (2012). Aggregation in quads but not pairs of rats exposed to cat odor or bright light. Behavioural Processes, 90(3), 331-336. [More Information]
  • McGregor, I., Bowen, M. (2012). Breaking the loop: Oxytocin as a potential treatment for drug addiction. Hormones and Behavior, 61(3), 331-339. [More Information]
  • Motbey, C., Hunt, G., Bowen, M., Artiss, S., McGregor, I. (2012). Mephedrone (4-Methylmethcathinone, "Meow"): Acute Behavioural Effects and Distribution of Fos Expression in Adolescent Rats. Addiction Biology, 17(2), 409-422. [More Information]
  • May, M., Bowen, M., McGregor, I., Timberlake, W. (2012). Rubbings deposited by cats elicit defensive behavior in rats. Physiology and Behavior, 107(5), 711-718. [More Information]
  • Bowen, M., Carson, D., Spiro, A., Arnold, J., McGregor, I. (2011). Adolescent Oxytocin Exposure Causes Persistent Reductions in Anxiety and Alcohol Consumption and Enhances Sociability in Rats. PloS One, 6(11), e27237-1-e27237-11. [More Information]
  • Kendig, M., Bowen, M., Kemp, A., McGregor, I. (2011). Predatory threat induces huddling in adolescent rats and residual changes in early adulthood suggestive of increased resilience. Behavioural Brain Research, 225(2), 405-414. [More Information]

2016

  • Peters, S., Bowen, M., Bohrer, K., McGregor, I., Neumann, I. (2016). Oxytocin inhibits ethanol consumption and ethanol induced dopamine release in the nucleus accumbens. Addiction Biology, In press. [More Information]
  • Bowen, M., Liu, J., Buisman-Pijlman, F. (2016). Oxytocin: Providing New Avenues for Treating and Understanding Problematic Drug Use. In Victor R. Preedy (Eds.), Neuropathology of Drug Addictions and Substance Misuse - Volume 1: Foundations of Understanding, Tobacco, Alcohol, Cannabinoids and Opioids, (pp. 82-92). London: Academic Press. [More Information]

2015

  • Bowen, M., Peters, S., Absalom, N., Chebib, M., Neumann, I., McGregor, I. (2015). Oxytocin prevents ethanol actions at δ subunitcontaining GABAA receptors and attenuates ethanolinduced motor impairment in rats. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 112(10), 3104-3109. [More Information]

2014

  • Bowen, M., Hari Dass, S., Booth, J., Suraev, A., Vyas, A., McGregor, I. (2014). Active coping toward predatory stress is associated with lower corticosterone and progesterone plasma levels and decreased methylation in the medial amygdala vasopressin system. Hormones and Behavior, 66(3), 561-566. [More Information]
  • Suraev, A., Bowen, M., Ali, S., Hicks, C., Ramos, L., McGregor, I. (2014). Adolescent exposure to oxytocin, but not the selective oxytocin receptor agonist TGOT, increases social behavior and plasma oxytocin in adulthood. Hormones and Behavior, 65(5), 488-496. [More Information]
  • Bowen, M. (2014). Miscellaneous Hormones. In Sidhartha D. Ray (Eds.), Side Effects of Drugs Annual: A worldwide yearly survey of new data in adverse drug reactions, (pp. 659-673). Amsterdam, Netherlands: Elsevier. [More Information]
  • Bowen, M., McGregor, I. (2014). Oxytocin and vasopressin modulate the social response to threat: a preclinical study. International Journal of Neuropsychopharmacology, 17, 1621-1633. [More Information]

2013

  • Bowen, M., Kevin, R., May, M., Staples, L., Hunt, G., McGregor, I. (2013). Defensive Aggregation (Huddling) in Rattus Norvegicus toward Predator Odor: Individual Differences, Social Buffering Effects and Neural Correlates. PloS One, 8(7), 1-15. [More Information]
  • Motbey, C., Clemens, K., Apetz, N., Winstock, A., Ramsey, J., Li, K., Wyatt, N., Callaghan, P., Bowen, M., Cornish, J., McGregor, I. (2013). High levels of intravenous mephedrone (4-methylmethcathinone) self-administration in rats: Neural consequences and comparison with methamphetamine. Journal of Psychopharmacology, 27(9), 823-836. [More Information]
  • McGregor, I., Bowen, M. (2013). Oxytocin and addiction: recent preclinical advances and future clinical potential. In E. Choleris, D. W. Pfaff, & M. Kavaliers (Eds.), Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior, (pp. 270-287). Cambridge, UK: Cambridge University Press.

2012

  • Bowen, M., Keats, K., Kendig, M., Cakic, V., Callaghan, P., McGregor, I. (2012). Aggregation in quads but not pairs of rats exposed to cat odor or bright light. Behavioural Processes, 90(3), 331-336. [More Information]
  • McGregor, I., Bowen, M. (2012). Breaking the loop: Oxytocin as a potential treatment for drug addiction. Hormones and Behavior, 61(3), 331-339. [More Information]
  • Motbey, C., Hunt, G., Bowen, M., Artiss, S., McGregor, I. (2012). Mephedrone (4-Methylmethcathinone, "Meow"): Acute Behavioural Effects and Distribution of Fos Expression in Adolescent Rats. Addiction Biology, 17(2), 409-422. [More Information]
  • May, M., Bowen, M., McGregor, I., Timberlake, W. (2012). Rubbings deposited by cats elicit defensive behavior in rats. Physiology and Behavior, 107(5), 711-718. [More Information]

2011

  • Bowen, M., Carson, D., Spiro, A., Arnold, J., McGregor, I. (2011). Adolescent Oxytocin Exposure Causes Persistent Reductions in Anxiety and Alcohol Consumption and Enhances Sociability in Rats. PloS One, 6(11), e27237-1-e27237-11. [More Information]
  • Kendig, M., Bowen, M., Kemp, A., McGregor, I. (2011). Predatory threat induces huddling in adolescent rats and residual changes in early adulthood suggestive of increased resilience. Behavioural Brain Research, 225(2), 405-414. [More Information]

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