Professor Peter Lay

FAA; FRACI; CChem; BSc Melbourne; PhD ANU
ARC Professorial Fellow
Professor of Inorganic Chemistry

F11 - Chemistry Building
The University of Sydney

Telephone 61 2 9351 4269
Fax 61 2 9351 3329

Website Contact Details

Biographical details

  • BSc, Melbourne, 1977
  • PhD, ANU, 1981
  • CSIRO (International) Postdoctoral Fellow, Stanford University, 1981-1983
  • CSIRO (International) Postdoctoral Fellow, CSIRO Division of Applied Organic Chemistry, 1983-1984
  • Queen Elizabeth II Fellow, Deakin University, 1984-1985
  • Visiting Fellow, ANU, 1983-1985
  • University of Sydney; Lecturer, 1985-1988; Senior Lecturer, 1989-1993; Reader, 1994-1996, Professor of Inorganic Chemistry, 1997 -
  • Visiting Professor, University of Berne, 1991
  • Associate Head of School (Research), 1997-2001
  • Distinguished Visiting Professor at the National University at Rosario (UNR), Argentina, 1999
  • Associate Director (Bio-Metals), Centre for Heavy Metals Research, 2000-2008
  • Head of School, 2001-2002
  • ARC Australian Professorial Fellow, 2002-2007
  • Academic Director, Foundation for Inorganic Chemistry at The University of Sydney, 2005-
  • ARC Australian Professorial Fellow, 2009-2013
  • Leader of the Biology and Genetics Stream, Breast Cancer Special Interest Group, Sydney Cancer Network, 2013-
  • Director, Vibrational Spectroscopy Core Facility of the University of Sydney, March 3, 2014 to February 28, 2017
  • ARC Australian Laureate Fellowships – Selection Advisory Committee, 2014

Research interests

  • Cr- and Ni-induced cancers
  • Vanadium and Cr(III) anti-diabetic drugs
  • Ruthenium and gallium anti-cancer drugs
  • X-ray absorption spectroscopy of drugs, biological fluids, cells and tissues
  • Vibrational spectroscopic imaging and mapping of cells and tissues in drug treatments and understanding diseases
  • Structural and spectroscopic studies of heme proteins
  • Electrochemistry
  • Copper anti-inflammatory drugs
  • Fullerene and fulleride electrochemistry and spectroscopy
  • Inorganic reaction mechanisms
  • Solvation, pi-backbonding and pi-bonding effects on reactivity of transition metal complexes

Bioinorganic Chemistry: Various aspects of the chemistry, biochemistry and cell biology of transition metal complexes of Cr and Ni (occupational cancers), V and Cr(III) (anti-diabetic agents), Ga and Ru (anti-cancer agents), Fe (heme proteins), and Cu (anti-inflammatory drugs) have been studied. A wide variety of spectroscopic, structural, biochemical and cell biology techniques have been employed to understand better the bioinorganic chemistry of these transition metals and to develop protective dietary protocols for metal induced cancers and to develop new potential pharmaceuticals.

Biospectroscopy, Imaging, and Mapping: Complementary imaging and mapping using X-ray absorption (synchrotron-induced X-ray emission, X-ray absorption near edge-structure), proton-induced X-ray emission, vibrational (FTIR and Raman), phase-contrast (X-ray and visible), fluorescence, and other spectromicroscopies are being used to study changes in biodistributions and concentrations of elements and biochemicals in cells and tissues as a result of diseases processes and their treatment. Biospectroscopy is also being used to develop new disease diagnostics. Diseases being studied include, cancer, diabetes, graft-versus host disease, malaria, meningitis, Parkinson's disease and other bacterial and viral infections.

Physical Inorganic Chemistry: A large range of spectroscopic, electrochemical and structural techniques has been used to gain fundamental insights into chemical reactivity of transition metal complexes and solvation effects on chemical reactivity. This also includes detailed studies of fullerenes and fullerides.

Current projects

Research Projects

Biospectroscopy, medicinal inorganic chemistry, and molecular and cell biology will be used to understand the mode of action of existing drugs, the design of new drugs and to learn more about normal physiological and disease processes at a molecular and cellular level. Projects will centre on metal-based anti-cancer and anti-diabetic drugs, the active sites of heme proteins, or the use of biospectroscopy in disease diagnosis.

Biochemistry of Cr, Mo and V Anti-Diabetic Drugs and Supplements

We have amassed evidence to implicate potentially carcinogenic Cr(VI/V) complexes as the active forms of Cr dietary supplements that are widely consumed for fat reduction and the treatment and prevention of diabetes. We are using similar techniques to those used in the Cr studies to unravel the biochemistry of V and Mo supplements that are also anti-diabetics. The studies are aimed at producing safer and more efficacious treatments for the prevention and treatment of diabetes. These projects will include studies of the interactions of the complexes with biomolecules and cells using various spectroscopic techniques, including microprobes (X-ray, Raman, FTIR and fluorescence).

Anti-Cancer Drugs

The anti-cancer properties of Ru complexes will be studied, since Ru complexes are one of few classes that have strong anti-metastatic activities. Investigations will involve studies on the ability of the Ru complexes to bind to blood proteins, extracellular matrices, the cell surface, and intracellular targets in order to bring about their activities. Separate studies on Ga, V (with Dr. A. Levina) and Rh anti-cancer drugs (with Drs. R. Baker and A. Levina) have also been shown considerable promise. A project focused on any one of these classes could include a combination of synthetic chemistry, biospectroscopy, and biochemical and cell biology assays.

Heme Proteins

Heme proteins have diverse biological roles and NO-heme adducts have been implicated in many of these roles. This project involves studies into the Raman and X-ray absorption spectroscopies of heme proteins in order to understand features of their chemistry, structures, and functions. Studies will involve investigations of isolated proteins that use the binding of NO or other small molecules in signal processes, the immune system, and/or for vasodilation, or the role of such proteins in cardiovascular disease. Research into the structures of intracellular heme proteins within cells is also possible.

Vibrational Spectroscopic Studies for Studies on Disease Processes and Diagnosis

Projects will involve the use of IR and Raman techniques to diagnose various diseases and to understand disease progression at the biochemical level. The techniques rely on the ability of vibrational spectroscopic techniques to differentiate changes in amounts and distributions of biochemicals. Research could concentrate on cancer, malaria, or cardiovascular disease, in collaboration with colleagues in a number of hospitals and medical institutes.

Associations

  • Royal Australian Chemical Society, Member, 1983-1993, Fellow, 1994-
  • American Chemical Society, Member, 1982-
  • Society of Electroanalytical Chemistry, Member, 1985-2009, Life Member, 2009-
  • International EPR(ESR) Society, Member, 1995-
  • Australian and New Zealand Magnetic Society (ANZMAG), Member, 1995-
  • American Society for the Advancement of Science, Member, 1997-
  • International Society for Bioinorganic Chemistry, Member, 1997-
  • New York Academy of Sciences, Member, 1998-2001
  • International X-Ray Absorption Society, Member, 2006-
  • Australian Academy of Science, Fellow, 2007-
  • Asia-Pacific EPR/ESR Society, Member 2008-

Awards and honours

  • CSIRO Postdoctoral Fellowship (International Award), 1981-1984
  • Bloom-Gutmann Prize (RACI Electrochemistry Division), 1984
  • Australian Research Council, QEII Fellow, 1984-1985
  • Rennie Medal, RACI, 1987
  • Edgeworth David Medal (Royal Society of NSW), 1988
  • The Bulletin – High Flyers of 1998 (one of five scientists), 1988
  • New Zealand Institute of Chemistry Lecturer, 1990
  • Fellow Royal Australian Chemical Institute, 1993
  • Burrows Award (RACI Inorganic Division), 2001
  • Australian Research Council Australian Professorial Fellow, 2002-2007
  • H. G. Smith Medal (RACI), 2005
  • Fellow, Australian Academy of Science, 2007
  • Australian Research Council Australian Professorial Fellow, 2009-2013
  • Commission Scientifique pour L'enseignement du 3e Cycle en Chimie Lecturer, Switzerland, Nov 2011
  • David Craig Medal, Australian Academy of Science, 2013

Selected grants

2015

  • Bruker Fourier Transform Infrared Circular Dichroism Accessory; Lay P, Hawkins C, Grau G, Witting P, Chan K; DVC Research/Equipment Grant.
  • Live Cell Accessories for Raman and FTIR Imaging; Lay P, Lakhwani G, Hawkins C, Bilek M, Matthews J; DVC Research/Equipment Grant.

2014

  • Emerging Vibrational Spectroscopic Breakthroughs: Rapid Infectious Disease Diagnosis, Evaluation of Drug Efficacy and Mechanisms of Disease Pathology $25,000; Lay P; DVC Research/HMR+ Implementation Fund – University.
  • University of Sydney Automated Peptide Synthesis Platform; Payne R, Britton W, Byrne S, Chan H, Clarke R, Hunt N, Jolliffe K, Kassiou M, Lay P, Mackay J, Matthews J, McErlean C, New E, Rasmussen H, Rendina L, Rudrawar S, Rutledge P, Shepherd N; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Pushing the Boundaries of Multi-modal Biospectroscopic Microscopies; Lay P, Harris H, Tobin M, Paterson D, De Jonge M, Glover C, Puskar L, Vogt S, Finney L; Australian Research Council (ARC)/Discovery Projects (DP).
  • CLARIOstar Multifunctional Microplate Reader for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Huang M, Scolyer R, Fraser S, Sahni S, Speranza T, Owens T, Barrs V, Ju Y, Kovacevic Z, Lu Z, Camp A, Slobedman B, Morris B, Oliver B, Dos Remedios C, Kalinowski D, Fu D, Lai D, Lovicu F, Allbutt H, Triccas J, Burgess J, Kril J, Dixon K, Rendina L, Byrne M, King N, Groundwater P, Williamson P, Ho J, Dong Q, Bao B, Assinder S, McLennan S, Richardson D, Ammit A, Sharland A, Hardikar A, Hong A, Hambly B, Lee C, Murphy C, Goldsbury C, Johnstone D, Lane D, Hibbs D, Joshua D, Huq F, Halliday G, Sutherland G, Zreiqat H, Lok H, Lyons G, Jansson P, Black J, Zhu L, Sunde M, Day M, Naylor M, Buckland M, Murray M, Shafie N, Lay P, Poronnik P, Codd R, Mason R, Ryan R, Christopherson R, de Graaf S; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2013

  • BioMark HD High-throughput Real Time & Digital PCR System for the Open Access, Multi-Disciplinary Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Lee C, Halliday G, Murray M, Lay P, Christie M, Kench J, Damian D, Hersey P; Cancer Institute New South Wales/Equipment Grant.
  • Perpetual Travel Grants for Prof Peter Lay; Lay P, Carter E; Australian Synchrotron Company Limited/International Access Program.
  • Robotic High Throughput Western Analysis for the Open Access, Multi-User Sydney Cancer Research Core Facility; Richardson D, Scolyer R, Boyer M, Halliday G, Damian D, Christopherson R, Joshua D, Kench J, Hong A, Murray M, Lee C, Kalinowski D, Naylor M, Lay P, Lyons G, Kovacevic Z, Mason R, Dixon K, Chan-Ling T, Hawkins C, Sunde M, Lovejoy D, Owens T, Rendina L, Jansson P, Dos Remedios C, Charles (nee Slaviero) K, Lane D, Witting P, Dong Q, Ammit A, Groundwater P, Assinder S, Bao B, Byrne S, Zhou F, Buckland M, Grewal T, Huq F, Lai D, Codd R, Zhang D, Fu D, de Graaf S, Huang M, Payne R, Slobedman B, Barrs V, Ho J, Williamson P, Murphy C; DVC Research/Equipment Grant.
  • Pulsed Electron Paramagnetic Resonance - an enhanced capability for research in quantum physics, materials science, chemistry and biological sciences; McCamey D, Moran G, Brown L, Dzurak A, Reilly D, Mackay J, Hamilton A, Lay P, Schmidt T; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • SF-61SX2/s stopped-flow fluorimeter and Service and upgrade of SX-17MV stopped-flow spectrometer; Clarke R, Davies M, Lay P, Witting P, Rasmussen H, Matthews J, Pattison D, Vandenberg J; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • QX100 Droplet Digital PCR system for Shared Used at the Open Access, Multi-User Molecular Biology Core Facility; Richardson D, Kril J, Murphy C, Vandenberg R, Rendina L, Dos Remedios C, Ju Y, Kovacevic Z, Lyons G, Sutherland G, Lay P, Ammit A, Lai D, Morris B, Day M, Dong Q, Bao B, Huang M, Camp A, Boyer M, Whittington R, Byrne M, Hanrahan J, Fu D, Jansson P, Lane D, Bagley E, Hibbs D, Zhang D, Fraser S, Scolyer R, Black J, Halliday G, Christie M, Zreiqat H, Murray M, Slobedman B, Naylor M, Burgess J, Triccas J, Mason R, Chadban S, Combes V, Lovicu F, McLennan S, Kalinowski D, Sharland A, Johnstone D, Groundwater P, Dixon K, Zhou F, Lovejoy D, Lu Z, Zhu L, Goldsbury C, Witting P, Buckland M, Assinder S, Purdie (Williams) A, Codd R, Owens T, Hambly B; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The Roles of Metal Complexes and Related Metalloproteins in the Essential and Therapeutic Control of Diabetes; Lay P; Australian Research Council (ARC)/Discovery Projects (DP).

2012

  • Reactivity of ruthenium anti-cancer complexes in biological fluids; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Gel Electrophoresis of Ru anti-cancer drugs with blood serum; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Chromium and Vanadium interactions in biological systems; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Infrared Spectroscopy of Live Cells to Investigate Glucose Metabolism - travel expenses; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer; Baxter R, Halliday G, Marsh D, Gill A, Clarke S, Smith R, Little C, Jackson C, O'Neill C, Murphy C, Sharland A, Chadban S, Mason R, Assinder S, Verdurand M, Richardson D, Machaalani R, Hambly B, Chan-Ling T, Dos Remedios C, Holsinger D, Lay P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Chromium and vanadium complexes: biotransformations in biological fluids and cells (ANBF); Levina A, Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Reactivity of ruthenium anti-cancer complexes in biological fluids (ANBF); Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Gel electrophoresis of ru anti-cancer drugs with blood serum; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Biodistributions and biotransformations of anti-diabetic drugs in target cells; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Studies of cellular uptake and distribution of gallium by a combination of fluorescence microscopy and X-ray fluorescence mapping; Lay P; Australian Synchrotron Company Limited/Funding Application for Interstate User Groups.
  • Reactivity of ruthenium anti-cnacer complexes in biological fluids (ANBF); Lay P; Australian Synchrotron Company Limited/International Access Program.

2011

  • Reactivity of Ruthenium Anti-Cancer Complexes in Biological Fluids (ANBF); Lay P, O'Riley H, Lim Z, Wood M; Australian Synchrotron Company Limited/International Access Program.
  • Infrared spectroscopy of live cells to investigate glucose metabolism; Lay P, Wood M; Australian Synchrotron Company Limited/International Access Program.
  • Cr and V interactions in biological systems; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Chromium and vanadium complexes:biotransformations in biological fluids and cells; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Reactivity of Ruthenium anti-cancer complexes in biological fluids (ANBF); Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Innovative Synchrotron Science - Access Program to the Australian National Beamline Facility and Cutting-Edge Beamlines at International Synchrotrons; Lay P, Waite T, Gerson, A, Harris H, Collins R, Dillon C, Brugger J, Garrett R, Wilce M, De Marco R, Tardio J, Spiccia L, Zhang L, Aguilar M, Hambley T, Harmer-Bassell S, Burton E, Bush R, Johnston S, Trevitt A, Kepert C, Chantler C, Shimomura O, Bond C, Gray E, Noller B, Gentle I, Sullivan L, Creagh D, Low I; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2010

  • Studies of cellular uptake and distribution of gallium by a combination of fluorescence microscopy and X-ray fluorescence mapping; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Cr interactions in biological systems; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • P2602: Reactivity of Ruthenium Anti-Cancer Complexes in Biological Fluids (ANBF); Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Pharmaceutical formulations for slow release of vanadium: potential oral anti-diabetic drugs; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Reactivity of Ruthenium Anti-Cancer Complexes in Biological Fluids; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • XAS of dilute protein samples; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Metal fluorescence labels. Do they confound the biochemical information they hope to provide?; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • STIMS and PIXE mapping of diseased cerebral and other tissues; Lay P; Australian Institute of Nuclear Science and Engineering (AINSE)/Awards.
  • Effects of a Ru(III) anti-cancer drug on the hierarchical structure of collagen fibres & Unfolding and Refolding of Bovine Serum Albumin Induced by a Ru(III) Anti-Cancer Drug; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Mechanistic aspects of gallium drugs as rediopharmaceutical and anti-cancer agents: multi-modal biospectroscopic studies; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Cr interactions in biological systems; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Design and Mechanistic Studies of Metal-Based Anti-Diabetic Drugs; Lay P; Australian Research Council (ARC)/Discovery Projects (DP).
  • Oxidative Stress Bioanalytical Facility; Stocker R, Hunt N, Mason R, Witting P, Roufogalis B, Lay P, Tiganis T, Davies M, Dawes I, Drummond G, Geczy C, Kachigian L, Hogg P, Lackmann M, Thomas S, Croft K, King N, Tilley L, James D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2009

  • A novel approach to determine the origin of the oldest evidence of life on Earth; Aitken J, Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Vanadium complexes: biotransformations in biological fluids; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Biotransformation products of Ruthenium anti-cancer complexes in blood and blood products; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Biotransformation products of Ruthenium anti-cancer complexes in blood and blood products; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Distribution of metal ions in cancerous vs. normal breast tissue using X-ray Fluorescence Microspectroscopy; Lay P, Jalilehvand F; Australian Synchrotron Company Limited/International Access Program.
  • Chromium and Vanadium Complexes: Biotransformations in Biological Fluids and Cells; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Biodistributions and Biotransformations of Vanadium Anti-Diabetic Drugs in Target Cells (GUP-9789); Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Investigating subcellular biochemistry using infrared, X-ray and fluorescent microscopies; Carter E, Lay P; Australian Synchrotron Company Limited/International Access Program.
  • V complexes and their interactions with diabetes models; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Ga complexes and their anti-cancer properties; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Microprobe and Nanoprobe Studies on Intracellular Disease Processes and Their Treatment; Lay P, Harris H, De Jonge M, Vogt S, Glover C, Pattison D, Tobin M, Foran G; Australian Research Council (ARC)/Discovery Projects (DP).
  • Australian Access to and Operation of Advanced Synchrotron Radiation Facilities at the Photon Factory; Ridgway M, Lay P; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • StreamLineTM Plus- Rapid Chemical Mapping; Lay P, Grau G, Richardson D, Hambley T, Witting P, Carter E; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • XAS Studies of Metal Anti-Diabetic Supplements and Drugs & XAS Studies on Heme Proteins; Lay P; Australian Nuclear Science and Technology Organisation/Research Support.

2008

  • Cellular Imaging of Manganese Metalloporphyrin Superoxide Dismutase Mimics; Aitken J, Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Biodistributions and Biotransformations of Vanadium Anti-Diabetic Drugs in Target Cells (GUP-9789); Lay P; Australian Synchrotron Company Limited/International Access Program.
  • Metal fluorescence labels. Do they confound the biochemical information they hope to provide?; Lay P; ARC/NHMRC Research Network for Fluorescence Applications in Biotechnology and Life Sciences (NHMRC)/FABLS Support Scheme for Emerging Research Projects.
  • Chromium Complexes: Biotransformations in Biological Fluids and Cells; Lay P, Aitken J; Australian Synchrotron Company Limited/International Access Program.
  • Molybdenum and Ruthenium Drugs: Reactions with biologically relevant thiols; Lay P; Australian Synchrotron Company Limited/International Access Program.
  • High Resolution Field Emission Scanning Electron Microscopy (FESEM) Platform for Characterisation at; Ringer S, Barton G, Ramzan I, Copeland L, Potts D, Braet F, Grillet C, Lay P, Murphy C, Cairney J, Ferry M, Eggleton B, McKenzie D, Masters A, Parker A, Overall R, Weiss A, Ruys A, Sorrell C, Ye L, Harris A, Ranzi G; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • PIXE elemental mapping of malarial diseased cerebral tissue; Lay P; Australian Institute of Nuclear Science and Engineering (AINSE)/Awards.
  • Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials and Medical Research; Lay P, McNaughton D, Maschmeyer T, Potts D, Swain M, Grau G, Sorrell T, Ramzan I, Beardall J, Bernard C, Marshall C, Dutkiewicz A, Penny D, Wood B, Yang W, Soon L, Traini D, Carter E; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • High-Resolution Field Emission Scanning Electron Microscopy (FESEM) Platform for Characterisation at the Nanometre-Level; Cairney J, Ringer S, Braet F, Ferry M, Sorrell C, Ye L, Ruys A, Barton G, Harris A, Ranzi G, Eggleton B, Grillet C, Mckenzie D, Lay P, Masters A, Parker A, Overall R, Weiss A, Murphy C, Ramzan I, Copeland L, Potts D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Application of 67Ga-labelling to the studies of metabolism of gallium compounds; Lay P; Australian Institute of Nuclear Science and Engineering (AINSE)/Awards.
  • Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological Materials, and Medical Research; Bernard C, Marshall C, Wood B, Potts D, Penny D, Dutkiewicz A, Grau G, Sorrell T, Swain M, Yang W, Soon L, Lay P, McNaughton D, Maschmeyer T, Ramzan I, Beardall J, Traini D, Carter E; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2007

  • Twister microplate handle: A robotic system for the Bruker HTS-XT infrared module.; Lay P, Hunt N, Grau G, Sorrell T, Witting P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • High-resolution electron tomographic facility for nanoanlytical characterization in the material an; Braet F, Ramzan I, Ringer S, Soon L, Liu Z, Hambley T, Lay P, Warr G, Thordarson P, Murphy C, Dos Remedios C, Weiss A, Parker A; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • The roles of metal ions in glucose metabolism and the treatment of diabetes; Lay P; Australian Research Council (ARC)/Discovery Projects (DP).
  • Biomolecular chemical survival strategies of terrestrail extremophiles and the spectroscopic search for life on Mars; Lay P, Marshall C, Carter E; Australian Research Council (ARC)/Linkage International: Linkage International Awards (LX).

2006

  • Time-Resolved Multilabel Counter; et a, Lay P, Soon L; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Combinatorial Deposition and Diagnostic Facility for New Alloy Thin Film Materials; Bilek M, Lay P, Ekins-Daukes N, James B, Kable S, Schmidt T, Ostrikov K, Valanoor N, O'Connor J, Green M, Conibeer G, Riley T, McKenzie D, King B, Hoffman M, Ferry M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Nanoprobe and Microprobe Structural and Spectroscopic Studies in Biomedical Research; Lay P, Harris H, Stampfl A, Stampf A; Australian Research Council (ARC)/Discovery Projects (DP).
  • Wallac VICTOR3 V Multilabel Counter; Lay P, Braet F; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Elemental and Structural Analysis Facility Comprising a FTICR Mass Spectrometer and a CHNS Analyser; Lay P, Kable S, Downard K, Johnston G, Hanrahan J, Fisher K, Maschmeyer T, Karuso P, Gore D, McLeod M, Jolliffe K; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2005

  • Vibrational Spectroscopy Microprobe/FESEM/AFM Imaging of Cells, Tissues and Materials; Lay P, Ringer S, Maschmeyer T, Sorrell T, McKenzie D, Eggleton B, Fleming S, et a; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Metal-based anti-inflammatory drugs with high efficacy and low side effects.; Hambley T, Lay P, Dillon C, Pearce S; Newbio Ltd/Newbio Pty Ltd.

2004

  • Metal-based Anti-inflammatory Drugs with High Efficacy and Low Side-effects (LP0453765); Kaur R, Stoker S, Lay P; Nature Vet Pty Ltd/Project Support.
  • OPTIMAX TLX 120 ultracentrifuge; Witting P, Handelsman D, Nicholson G, Lay P, Kritharides L, Kril J, Le Couteur D, Lowe H, Kennerson M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Molecular and Materials Structure Network; Turner P, Kepert C, Collins M, Hambley T, Hanrahan J, Kennedy B, Lay P; Australian Research Council (ARC)/Research Networks (ARCRN).
  • Metal-based anti-inflammatory drugs with high efficacy and low side-effects; Hambley T, Lay P, Dillon C, Pearce S; Australian Research Council (ARC)/Linkage Projects (LP).
  • Nickel(III) & nickel-dioxygen peptide complexes - biomimetics of biological carcinogens and enzymes; Lay P; DVC Research/Research and Development Scheme: Research and Development (R&D).

2003

  • Metals in medicine; Lay P; Australian Research Council (ARC)/Special Research Initiatives (SRI).
  • Not known; Lay P; University of Sydney/Cancer Research Fund.
  • Nanoprobe and Microprobe Spectroscopic Techniques in Drug Design Probing Mechanisms of Diseases and Bioinorganic Chemistry; Armstrong R, Lay P; Australian Research Council (ARC)/Discovery Projects (DP).
  • Fluorescence detector for he Australian National Beamline Facility; Berry A, Gerson, A, Hambley T, Bhargava S, Garrett R, Foran G, Ridgway M, Gentle I, Best S, Riley T, Creagh D, Lay P; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Australian Synchrotron Research Program Fellowship - Dr Hugh Harris; Harris H, Lay P; Australian Nuclear Science and Technology Organisation/Research Grant.

2002

  • In vivo and in vitro microprobe and nanoprobe spectrocsopic techniques in drug design, probing mechanisms of disease and bioinorganic chemistry; Lay P; DVC Research/Research and Development Scheme: Research and Development (R&D).
  • NO adducts of heme proteins (includes studies on bioinorganic Mn, Cu, Cr XAFS) - SSRL, USA, 20 February 2002, 7 days; Lay P; Australian Nuclear Science and Technology Organisation (ANSTO)/Research Grant.
  • The Chemistry and Biochemistry of Chromium: Cancer and Nutrition; Lay P; Australian Research Council (ARC)/Discovery Projects (DP).
  • L-Band EPR spectroscopic studies of radicals in mammalian cells and tissues, and biological fluids; Lay P; WELLCOME TRUST/Research Grant.

2001

  • New Metal Complexes of NSAIDs as Veterinary Eye Ointments, Anti-Cancer Drugs and General Anti-inflam; Lay P, Hambley T, Kennedy B, Warwick B, Davies N, Weder J, Regtop H, Biffin J, Craft M; Australian Research Council (ARC)/Strategic Partnerships with Industry - Research and Training (SPIRT).
  • In Vitro Spectroscopic and Structural Studies of the Metabolism of Carcinogenic Chromium (VI) Complexes; Lay P; Australian Research Council (ARC)/Large Research Grants (LRG).
  • NO adducts of heme proteins (includes studies on bioinorganic Mn, Cu, Cr XAFS); Lay P; Australian Nuclear Science and Technology Organisation/Access to Major Research Facilities Program.

2000

  • XAS studies on dilute solutions of heme proteins - SSRL, Stanford, USA, 18 January 2000, 11 days; Lay P; Australian Nuclear Science and Technology Organisation/Access to Major Research Facilities Program.
  • Characterisations and reactivites of Cr(VI), Cr(V) and Cr(IV) intermediates. Implications for Cr-induced cancers and oxidation of organic substrates.; Lay P; Australian Research Council (ARC)/Large Research Grants (LRG).
  • Development and mechanisms of action of new non-steroidal anti-imflammatory copper drugs with high activities and low side effects; Lay P, Kennedy B, Hambley T, Zhou Q; Australian Research Council (ARC)/Strategic Partnerships with Industry - Research and Training (SPIRT).
  • New developments in fullerene chemistry; Australian Research Council (ARC)/Linkage International: ARC International Fellowships (ARCIF).
  • Fullerenes, fulleride and their complexes. Synthesis, spectroscopy and biological activity; Armstrong R, Reed C, Lay P; Australian Research Council (ARC)/Large Research Grants (LRG).
  • ANSTO Access to Major Research Facilities Program to visit Stanford, USA, commencing 26 January 2000 for 7 days for 1 person; Lay P; Australian Nuclear Science and Technology Organisation/Major Research Facilities Program.
  • NO adducts of heme proteins - SSRL, Stanford, USA, 26 January 2000, 7 days; Armstrong R, Lay P; Australian Nuclear Science and Technology Organisation (ANSTO)/Research Grant.
  • Australian Synchrotron Research Program; Lay P; Australian Nuclear Science and Technology Organisation/Major Research Facilities Program.

1999

  • SPIRT 2001: new metal complexes of NSAIDs as veterinary eye ointments, anti-cancer drugs and general; Lay P, Hambley T, Weder J, Morgan Y.

Selected publications

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Book Chapters

  • Levina, A., Codd, R., Lay, P. (2009). Chromium in cancer and dietary supplements. In G. R. Hanson and L. J. Berliner (Eds.), Biological Magnetic Resonance: High Resolution EPR Applications to Metalloenzymes and Metals in Medicine, (pp. 551-579). NY, USA: Springer.
  • Carter, E., Marshall, C., Ali, M., Ganendren, R., Sorrell, T., Wright, L., Lee, Y., Chen, C., Lay, P. (2007). Infrared Spectroscopy of Microorganisms: Characterization, Identification, and Differentiation. In Katrin Kneipp, Ricardo Aroca, Harald Kneipp and Edeline Wentrup-Byrne (Eds.), New Approaches in Biomedical Spectroscopy, (pp. 64-84). Washington DC, United States: American Chemical Society.
  • Levina, A., Mulyani, I., Lay, P. (2007). Redox chemistry and biological activities of chromium(III) complexes. In J. B. Vincent (Eds.), The Nutritional Biochemistry of Chromium(III), (pp. 225-256). Amsterdam, Netherlands: Elsevier.
  • Lay, P., Levina, A. (2004). Chromium. In A. G. Webb (Eds.), Comprehensive Coordination Chemistry II : From Biology to Nanotechnology [Volume 4: Transition Metal Groups 3-6], (pp. 313-413). Amsterdam: Pergamon Elsevier.
  • Dillon, C., Hambley, T., Kennedy, B., Lay, P., Weder, J., Zhou, Q. (2004). Copper And Zinc Complexes As Antiinflammatory Drugs. In Astrid Sigel & Helmut Sigel (Eds.), Metal Ions in Biological Systems : Volume 41 : Metal Ions and their Complexes in Medication, (pp. 253-277). New York: Marcel Dekker.
  • Levina, A., Codd, R., Dillon, C., Lay, P. (2003). Chromium in Biology: Toxicology and Nutritional aspects. In Karlin, Kenneth D (Eds.), Progress in Inorganic Chemistry, Volume 51, (pp. 145-250). Hoboken: John Wiley & Sons.

Journals

  • Levina, A., Lay, P. (2014). Influence of an anti-metastatic ruthenium(III) prodrug on extracellular protein-protein interactions: studies by bio-layer interferometry. Inorganic Chemistry Frontiers, 1(1), 44-48. [More Information]
  • Kong, S., Chan, B., Park, J., Hill, K., Aitken, J., Cottle, L., Farghaian, H., Cole, A., Lay, P., Sue, C., et al (2014). Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes alpha-Synuclein externalization via exosomes. Human Molecular Genetics, 23(11), 2816-2833. [More Information]
  • Levina, A., McLeod, A., Kremer, L., Aitken, J., Glover, C., Johannessen, B., Lay, P. (2014). Reactivity-activity relationships of oral anti-diabetic vanadium complexes in gastrointestinal media: an X-ray absorption spectroscopic study. Metallomics, 6(10), 1880-1888. [More Information]
  • Pham, T., Aitken, J., Levina, A., Lay, P. (2014). Solid-state structural studies of chromium(III) nicotinato nutritional supplements. Inorganic Chemistry, 53(19), 10685-10694. [More Information]
  • Aitken, J., Austin, C., Hunt, N., Ball, H., Lay, P. (2014). The Fe-heme structure of met-indoleamine 2,3-dioxygenase-2 determined by X-ray absorption fine structure. Biochemical and Biophysical Research Communications, 450(1), 25-29. [More Information]
  • Levina, A., McLeod, A., Lay, P. (2014). Vanadium speciation by XANES spectroscopy: A three-dimensional approach. Chemistry: A European Journal, 20(38), 12056-12060. [More Information]
  • Dickson, C., Rich, A., D'Avigdor, W., Collins, D., Lowry, J., Mollan, T., Khandros, E., Olson, J., Weiss, M., Mackay, J., Lay, P., et al (2013). Alpha-hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-alpha-hemoglobin and weakens the iron-oxygen bond. Journal of Biological Chemistry, 288(27), 19986-20001. [More Information]
  • Levina, A., Aitken, J., Gwee, Y., Lim, Z., Liu, M., Singharay, A., Wong, P., Lay, P. (2013). Biotransformations of anticancer ruthenium(III) complexes: An X-ray absorption spectroscopic study. Chemistry: A European Journal, 19(11), 3609-3619. [More Information]
  • Aitken, J., Shearer, E., Giles, N., Lai, B., Vogt, S., Reboucas, J., Batinic-Haberle, I., Lay, P., Giles, G. (2013). Intracellular targeting and pharmacological activity of the superoxide dismutase mimics MnTE-2-PyP(5+) and MnTnHex-2-PyP(5+) regulated by their porphyrin ring substituents. Inorganic Chemistry, 52(8), 4121-4123. [More Information]
  • Bartholomaus, R., Irwin, J., Shi, L., Meejoo Smith, S., Levina, A., Lay, P. (2013). Isolation, Characterization, and Nuclease Activity of Biologically Relevant Chromium(V) Complexes with Monosaccharides and Model Diols. Likely Intermediates in Chromium-Induced Cancers. Inorganic Chemistry, 52(8), 4282-4292. [More Information]
  • Lee, J., Siegele, R., Pastuovic, Z., Hackett, M., Hunt, N., Grau, G., Cohen, D., Lay, P. (2013). Light and heavy ion beam analysis of thin biological sections. Nuclear Instruments and Methods in Physics Research. Section B, 306, 129-133. [More Information]
  • Zeng, A., Bilek, M., McKenzie, D., Lay, P., Boo, J. (2013). Native oxides and their effect on electrochemical characteristics of ta-C:N films. Surface and Coatings Technology, 228(Supplement 1), S486-S489. [More Information]
  • Hackett, M., Lee, J., El Assaad, F., McQuillan, J., Carter, E., Grau, G., Hunt, N., Lay, P. (2012). FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: General implications for disease neurochemistry. ACS Chemical Neuroscience, 3(12), 1017-1024. [More Information]
  • Aitken, J., Lay, P., Duong, T., Aran, R., Witting, P., Harris, H., Lai, B., Vogt, S., Giles, G. (2012). Synchrotron radiation induced X-ray emission studies of the antioxidant mechanism of the organoselenium drug ebselen. Journal of Biological Inorganic Chemistry, 17(4), 589-598. [More Information]
  • Bartholomaus, R., Harms, K., Levina, A., Lay, P. (2012). Synthesis and characterization of a chromium(V) cis-1,2-cyclohexanediolato complex: A model of reactive intermediates in chromium-induced cancers. Inorganic Chemistry, 51(21), 11238-11240. [More Information]
  • George, G., Pickering, I., Pushie, M., Nienaber, K., Hackett, M., Ascone, I., Hedman, B., Hodgson, K., Aitken, J., Levina, A., Lay, P., et al (2012). X-ray-induced photo-chemistry and X-ray absorption spectroscopy of biological samples. Journal of Synchrotron Radiation, 19(6), 875-886. [More Information]
  • Hackett, M., McQuillan, J., El Assaad, F., Aitken, J., Levina, A., Cohen, D., Siegele, R., Carter, E., Grau, G., Hunt, N., Lay, P. (2011). Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis. The Analyst, 136(14), 2941-2952. [More Information]
  • Hackett, M., Siegele, R., El Assaad, F., McQuillan, J., Aitken, J., Carter, E., Grau, G., Hunt, N., Cohen, D., Lay, P. (2011). Investigation of the mouse cerebellum using STIM and μ-PIXE spectrometric and FTIR spectroscopic mapping and imaging. Nuclear Instruments and Methods in Physics Research. Section B, 269(20), 2260-2263. [More Information]
  • Levina, A., Lay, P. (2011). Metal-based anti-diabetic drugs: Advances and challenges. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 40(44), 11675-11686. [More Information]
  • Aitken, J., Levina, A., Lay, P. (2011). Studies on the Biotransformations and Biodistributions of Metal-Containing Drugs Using X-ray Absorption Spectroscopy. Current Topics in Medicinal Chemistry, 11(5), 553-571. [More Information]
  • Liu, M., Lim, Z., Gwee, Y., Levina, A., Lay, P. (2010). Characterization of a ruthenium(III)/NAMI-A adduct with bovine serum albumin that exhibits a high anti-metastatic activity. Angewandte Chemie (International Edition), 49(9), 1661-1664. [More Information]
  • Levina, A., Zhang, L., Lay, P. (2010). Formation and reactivity of chromium(V)-thiolato complexes: A model for the intracellular reactions of carcinogenic chromium(VI) with biological thiols. Journal of the American Chemical Society, 132(25), 8720-8731.
  • Finney, L., Chishti, Y., Khare, T., Giometti, C., Levina, A., Lay, P., Vogt, S. (2010). Imaging metals in proteins by combining electrophoresis with rapid X-ray fluorescence mapping. ACS Chemical Biology, 5(6), 577-587.
  • Bonin, A., Yanez, J., Fukuda, C., Teng, X., Dillon, C., Hambley, T., Lay, P., Davies, N. (2010). Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. Cancer Chemotherapy and Pharmacology, 66(4), 755-764. [More Information]
  • Carter, E., Rayner, B., McLeod, A., Wu, L., Marshall, C., Levina, A., Aitken, J., Witting, P., Lai, B., Cai, Z., Harris, H., Lay, P., et al (2010). Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells. Molecular BioSystems, 6(7), 1316-1322. [More Information]
  • Aitken, J., Carter, E., Eastgate, H., Hackett, M., Harris, H., Levina, A., Lee, Y., Chen, C., Lai, B., Vogt, S., Lay, P. (2009). Biomedical applications of X-ray absorption and vibrational spectroscopic microscopies in obtaining structural information from complex systems. Radiation Physics and Chemistry, 79(2), 176-184.
  • Zeng, A., Bilek, M., McKenzie, D., Lay, P. (2009). Correlation of film structure and molecular oxygen reduction at nitrogen doped amorphous carbon thin film electrochemical electrodes. Diamond and Related Materials, 18(9), 1102-1108. [More Information]
  • Sargeson, A., Lay, P. (2009). Dependence of the properties of cobalt(III) cage complex as a function of the derivatization of amine substituents. Australian Journal of Chemistry: an international journal for chemical science, 62(10), 1280-1290.
  • Duong, T., Witting, P., Antao, S., Parry, S., Kennerson, M., Lai, B., Vogt, S., Lay, P., Harris, H. (2009). Multiple protective activities of neuroglobin in cultured neuronal cells exposed to hypoxia re-oxygenation injury. Journal of Neurochemistry, 108(5), 1143-1154. [More Information]
  • Levina, A., Singharay, A., Lay, P. (2009). Recent developments in ruthenium anticancer drugs. Metallomics, 1(6), 458-470.
  • Harris, H., Vogt, S., Lay, P. (2009). Response to Guzzi & Pigattos Comments on Migration of mercury from dental amalgam through human teeth by H. H. Harris et al. (2008). J. Synchrotron Rad. 15, 123-128. Journal of Synchrotron Radiation, 16(3), 437-438.
  • Zeng, A., Bilek, M., McKenzie, D., Lay, P. (2009). Semiconductor properties and redox responses at a-C:N thin film electrochemical electrodes. Diamond and Related Materials, 18(10), 1211-1217. [More Information]
  • Carter, E., Tam, K., Armstrong, R., Lay, P. (2009). Vibrational spectroscopic mapping and imaging of tissues and cells. Biophysical Reviews, 1(2), 95-103. [More Information]
  • Harris, H., Vogt, S., Eastgate, H., Lay, P. (2008). A link between copper and dental caries in human teeth identified by X-ray fluorescence elemental mapping. Journal of Biological Inorganic Chemistry, 13(2), 303-306. [More Information]
  • Chatterjee, D., Singharay, A., Levina, A., Lay, P. (2008). A potential role for protein tyrosine phosphatase inhibition by a Ru(III)-edta complex (edta = ethylenediaminetetraacetate) in its biological activity. Chemical Communications, 2008 (25), 2864-2866.
  • Levina, A., Lay, P. (2008). Chemical properties and toxicity of chromium(III) nutritional supplements. Chemical Research in Toxicology, 21(3), 563-571.
  • Zeng, A., Bilek, M., McKenzie, D., Lay, P., La Fontaine, A., Keast, V. (2008). Correlation between film structures and potential limits for hydrogen and oxygen evolutions at a-C:N film electrochemical electrodes. Carbon, 46(4), 663-670. [More Information]
  • Zeng, A., Bilek, M., McKenzie, D., Lay, P. (2008). Deposition of a-C:N films and evaluation of their robustness in electrochemical applications. Thin Solid Films, 516(16), 5231-5235.
  • Harris, H., Vogt, S., Eastgate, H., Legnini, D., Hornberger, B., Cai, Z., Lai, B., Lay, P. (2008). Migration of mercury from dental amalgam through human teeth. Journal of Synchrotron Radiation, 15(2), 123-128.
  • Nguyen, A., Mulyani, I., Levina, A., Lay, P. (2008). Reactivity of chromium(III) nutritional supplements in biological media: An X-ray absorption spectroscopic study. Inorganic Chemistry, 47(10), 4299-4309.
  • Vogt, S., Lai, B., Finney, L., Palmer, B., Wu, L., Harris, H., Paunesku, T., de Jonge, M., Legnini, D., Maser, J., Lay, P., et al (2007). Imaging trace elements in cells with X-ray fluorescence microscopy. Microscopy and Microanalysis, 13((Suppl 2)), 40-41. [More Information]
  • Thomas, S., Terentis, A., Cai, H., Takikawa, O., Levina, A., Lay, P., Freewan, M., Stocker, R. (2007). Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide. Journal of Biological Chemistry, 282(33), 23778-23787. [More Information]
  • Levina, A., McLeod, A., Seuring, J., Lay, P. (2007). Reactivity of potential anti-diabetic molybdenum(VI) complexes in biological media: A XANES spectroscopic study. Journal of Inorganic Biochemistry, 101(11-12), 1586-1593. [More Information]
  • Levina, A., Harris, H., Lay, P. (2007). X-ray Absorption and EPR Spectroscopic Studies of the Biotransformations of Chromium(VI) in Mammalian Cells. Is Chromodulin an Artifact of Isolation Methods? Journal of the American Chemical Society, 129(5), 1065-1075.
  • Levina, A., Harris, H., Lay, P. (2006). Binding of chromium(VI) to histones: implications for chromium(VI)-induced genotoxicity. Journal of Biological Inorganic Chemistry, 11(2), 225-234. [More Information]
  • Milsmann, C., Levina, A., Harris, H., Foran, G., Turner, P., Lay, P. (2006). Charge distribution in chromium and vanadium catecholato complexes: X-ray absorption spectroscopic and computational studies. Inorganic Chemistry, 45(12), 4743-4754.
  • Codd, R., Lay, P., Tsibakhashvili, N., Kalabegishvili, T., Murusidze, I., Holman, H. (2006). Chromium(V) complexes generated in Arthrobacter oxydans by simulation analysis of EPR spectra. Journal of Inorganic Biochemistry, 100(11), 1827-1833. [More Information]
  • Armstrong, R., Foran, G., Hough, W., D'Alessandro, D., Lay, P., Crossley, M. (2006). Spectroelectrochemical evidence for communication within a laterally-bridged dimanganese(III) bis-porphyrin. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2006 (40), 4805-4813.
  • Shi, L., Jing, H., Ren, G., Levina, A., Lay, P. (2006). Studies on the mechanism of Cr-induced DNA damage in glucose and its derivative. Weisheng Yanjiu, 35, 348-351.
  • Witting, P., Harris, H., Rayner, B., Aitken, J., Dillon, C., Stocker, R., Lai, B., Cai, Z., Lay, P. (2006). The Endothelium-Derived Hyperpolarizing Factor, H-2O-2, Promotes Metal-Ion Efflux in Aortic Endothelial Cells: Elemental Mapping by a Hard X-ray Microprobe. Biochemistry, 45(41), 12500-12509. [More Information]
  • Immoos, C., Sulc, F., Farmer, P., Czarnecki, K., Bocian, D., Levina, A., Aitken, J., Armstrong, R., Lay, P. (2005). Bonding in HNO-myoglobin as characterized by X-ray absorption and resonance Raman spectroscopies. Journal of the American Chemical Society, 127(3), 814-815.
  • Mactier, S., Luxenhofer, R., Levina, A., Codd, R., Lay, P. (2005). Chromium(V) complexes of hydroxamic acids: Formation, structures, and reactivities. Inorganic Chemistry, 44(8), 2934-2943. [More Information]
  • Barnard, P., Levina, A., Lay, P. (2005). Chromium(V) peptide complexes: Synthesis and spectroscopic characterization. Inorganic Chemistry, 44(4), 1044-1053.
  • Levina, A., Lay, P. (2005). Mechanistic studies of relevance to the biological activities of chromium. Coordination Chemistry Reviews, 249(3-4), 281-298. [More Information]
  • Ramadan, S., Bonin, A., Kennedy, B., Hambley, T., Lay, P. (2005). Nuclear magnetic resonance analysis of indomethacin-induced gastric ulcers. Chemical Research in Toxicology, 18(2), 123-128.
  • Signorella, S., Garcia, S., Rizzotto, M., Levina, A., Lay, P., Sala, L. (2005). The EPR pattern of Cr-V complexes of D-ribose derivatives. Polyhedron, 24(9), 1079-1085.
  • Levina, A., Armstrong, R., Lay, P. (2005). Three-dimensional structure determination using multiple-scattering analysis of XAFS: applications to metalloproteins and coordination chemistry. Coordination Chemistry Reviews, 249(1-2), 141-160. [More Information]
  • Harris, H., Levina, A., Dillon, C., Mulyana, Y., Lai, B., Cai, Z., Lay, P. (2005). Time-dependent uptake, distribution and biotransformation of chromium(VI) in individual and bulk human lung cells: application of synchrotron radiation techniques. Journal of Biological Inorganic Chemistry, 10(2), 105-118. [More Information]
  • Mulyani, I., Levina, A., Lay, P. (2004). Biomimetic Oxidation Of Chromium(III): Does The Antidiabetic Activity Of Chromium(III) Involve Carcinogenic Chromium(VI)? Angewandte Chemie (International Edition), 43(34), 4504-4507. [More Information]
  • Aitken, J., Thomas, S., Stocker, R., Thomas, S., Takikawa, O., Armstrong, R., Lay, P. (2004). Determination Of The Nature Of The Heme Environment In Nitrosyl Indoleamine 2,3-Dioxygenase Using Multiple-Scattering Analyses Of X-Ray Absorption Fine Structure. Biochemistry, 43(17), 4892-4898.
  • Feng, L., Gell, D., Zhou, S., Gu, L., Kong, Y., Li, J., Hu, M., Yan, N., Lee, C., Rich, A., Armstrong, R., Lay, P., Mackay, J., et al (2004). Molecular Mechanism Of AHSP-Mediated Stabilization Of A-Hemoglobin. Cell, 119(5), 629-640.
  • Ramadan, S., Hambley, T., Kennedy, B., Lay, P. (2004). Nmr Spectroscopic Characterization Of Copper(Ii) And Zinc(Ii) Complexes Of Indomethacin. Inorganic Chemistry, 43(9), 2943-2946.
  • Li, J., Sun, Z., Zhu, X., Zeng, H., Xu, Z., Wang, Z., lin, J., Huang, W., Armstrong, R., Lay, P. (2004). Optical Bistability For Zno-Nb2O5-Teo2 Glasses. Optical Materials, 25(4), 401-405.
  • Rayner, B., Stocker, R., Lay, P., Witting, P. (2004). Regio- And Stereo-Chemical Oxidation Of Linoleic Acid By Human Myoglobin And Hydrogen Peroxide: Tyr(103) Affects Rate And Product Distribution. Biochemical Journal, 381(2), 365-372.
  • Levina, A., Lay, P. (2004). Solution Structures Of Chromium(Vi) Complexes With Glutathione And Model Thiols. Inorganic Chemistry, 43(1), 324-335.
  • Weeks, C., Levina, A., Dillon, C., Turner, P., Fenton, R., Lay, P. (2004). Synthesis And Characterization Of A Chromium(V) Cis-Dioxo Bis(1,10-Phenanthroline) Complex And Crystal Molecular Structures Of Its Chromium(Iii) Precursor. Inorganic Chemistry, 43(24), 7844-7856.
  • Anderberg, P., Harding, M., Lay, P. (2004). The Effect Of Metal Ions On The Electrochemistry Of The Antitumor Antibiotic Streptonigrin. Journal of Inorganic Biochemistry, 98(5), 720-726. [More Information]
  • Gallagher, S., Thompson, K., Armstrong, R., Lay, P. (2004). The Unusual Intensity Behavior Of The 281-Cm(-1) Resonance Raman Band Of C-60: A Complex Tale Of Vibronic Coupling, Symmetry Reduction, Solvatochromism, And Jahn - Teller Activity. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 108(26), 5564-5572.
  • Levina, A., Foran, G., Pattison, D., Lay, P. (2004). X-Ray Absorption Spectroscopic And Electrochemical Studies Of Tris(Catecholato (2-))Chromate (V/I V/Iii) Complexes. Angewandte Chemie (International Edition), 43(4), 462-465. [More Information]
  • Levina, A., Codd, R., Foran, G., Hambley, T., Maschmeyer, T., Masters, A., Lay, P. (2004). X-Ray Absorption Spectroscopic Studies Of Chromium(V/Iv/Iii)2-Ethyl-2-Hydroxybutanoato(2-/1-) Complexes. Inorganic Chemistry, 43(3), 1046-1055.
  • Beattie, J., Beck, C., Lay, P., Masters, A. (2003). Chemistry of cobalt acetate. 7. Electrochemical oxidation of mu3-oxo-centered cobalt(III) acetate trimers. Inorganic Chemistry, 42(25), 8366-8370.
  • Mulyani, I., Levina, A., Lay, P. (2003). Chromium(III) complexes used as nutritional supplements: structures and reactivities. Journal of Inorganic Biochemistry, 961, 196.
  • Dillon, C., Hambley, T., Kennedy, B., Lay, P., Zhou, Q., Davies, N., Biffen, R., Regtop, H. (2003). Gastrointestinal Toxicity, Antiinflammatory Activity, and Superoxide Dismutase Activity of Copper and Zinc Complexes of the Antiinflammatory Drug Indomethacin. Chemical Research in Toxicology, 16(1), 28-37.
  • Dillon, C., Kennedy, B., Lay, P., Lai, B., Cai, Z., Stampfl, A., Ilinski, P., Legnini, D., Maser, J., Rodrigues, W., et al (2003). Implementation of X-ray microscopy and micro-XANES analysis for investigations of the cellular uptake and cellular metabolism of transition metals. Journal de Physique IV (France), 104, 293-296.
  • Codd, R., Lay, P. (2003). Oxochromium(V) species formed with 2,3-dehydro-2-deoxy-N-acetylneuraminic or N-acetylneuraminic (Sialic) acids: an in vitro model system of oxochromium(V) species potentially stabilized in the respiratory tract upon inhalation of carcinogenic chromium(VI). Chemical Research in Toxicology, 16(7), 881-892.
  • Codd, R., Irwin, J., Lay, P. (2003). Sialoglycoprotein and carbohydrate complexes in chromium toxicity. Current Opinion In Chemical Biology, 7, 213-219.
  • Levina, A., Zhang, L., Lay, P. (2003). Structure and reactivity of a chromium(V) glutathione complex. Inorganic Chemistry, 42(3), 767-784.
  • Cawich, C., Ibrahim, A., Link, K., Bumgartner, A., Patro, M., Mahapatro, S., Lay, P., Levina, A., Eaton, S., Eaton, G. (2003). Synthesis of a pyridinium bis[citrato(2-)]oxochromate(V) complex and its ligand-exchange reactions. Inorganic Chemistry, 42(20), 6458-6468.
  • Kim, K., Hauke, F., Hirsch, A., Boyd, P., Carter, E., Armstrong, R., Lay, P., Reed, C. (2003). Synthesis of the C59N+ carbocation. A monomeric azafullerene isoelectronic to C60. Journal of the American Chemical Society, 125(14), 4024-4025.
  • Levina, A., Turner, P., Lay, P. (2003). X-ray absorption spectroscopic studies of chromium nitroso complexes. Crystal and molecular strucute of (Ph4P)3[Cr(NO)(NCS)5].2.4(Ch3)2CO. Inorganic Chemistry, 42(17), 5392-5398.
  • Zhou, Q., Hambley, T., Kennedy, B., Lay, P. (2003). XAFS studies of anti-inflammatory dinuclear and mononuclear Zn(II) complexes of indomethacin. Inorganic Chemistry, 42(25), 8557-8566.
  • Weder, J., Dillon, C., Hambley, T., Kennedy, B., Lay, P., Biffin, J., Regtop, H., Davies, N. (2002). Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized. Coordination Chemistry Reviews, 232(1-2), 95-126.
  • Dillon, C., Lay, P., Kennedy, B., Stampfl, A., Cai, Z., Ilinski, P., Rodrigues, W., Legnini, D., Lai, B., Maser, J. (2002). Hard X-ray microprobe studies of chromium(VI)-treated V79 Chinese hamster lung cells: intracellular mapping of the biotransformation products of a chromium carcinogen. Journal of Biological Inorganic Chemistry, 7, 640-645. [More Information]
  • Weeks, C., Turner, P., Fenton, R., Lay, P. (2002). Nickel(II) complexes with amide ligands: oxidative dehydrogenation of the amines in a tetradentate diamide-diamine ligand. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 10(6), 931-940.
  • Rizzotto, M., Levina, A., Santoro, M., García, S., Frascaroli, M., Signorella, S., Sala, L., Lay, P. (2002). Redox and ligand-exchange chemistry of chromium(VI/V)-methyl glycoside systems. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, , 3206-3213.
  • Witting, P., Mauk, A., Lay, P. (2002). Role of Tyrosine-103 in Myoglobin Peroxidase Activity: Kinetic and Steady-State Studies on the Reaction of Wild-Type and Variant Recombinant Human Myoglobins with H2O2. Biochemistry, 41(38), 11495-11503.
  • Pattison, D., Levina, A., Lay, P., Davies, M. (2001). An investigation of the chromium oxidation state of a monoanionic chromium tris(catecholate) complex by X-ray absorption and EPR spectroscopies. Inorganic Chemistry, 40, 214-217.
  • Codd, R., Lay, P. (2001). Chromium(V)-sialic (neuraminic) acid species are formed from mixtures of chromium(VI) and saliva. Journal of the American Chemical Society, 123, 11799-11800.
  • Pattison, D., Levina, A., Lay, P., Davies, M., Dixon, N. (2001). Chromium(VI) reduction by catechol(amine)s results in DNA cleavage in vitro: Relevance to chromium genotoxicity. Chemical Research in Toxicology, 14, 500-510.
  • Weder, J., Hambley, T., Kennedy, B., Lay, P., Rich, A., Foran, G. (2001). Determination of the structures of antiinflammatory copper(II) dimers of indomethacin by multiple-scattering analyses of X-ray absorption fine structure data. Inorganic Chemistry, 40, 1295-1302.
  • Headlam, H., Weeks, C., Turner, P., Hambley, T., Lay, P. (2001). Dinuclear chromium(V) amino acid complexes from the reduction of chromium(VI) in the presence of amino acid ligands: XAFS characterization of a chromium(V) amino acid complex. Inorganic Chemistry, 40, 5097-5105.
  • Levina, A., Lay, P., Dixon, N. (2001). Disproportionation of a model chromium(V) complex causes extensive chromium(III)-DNA binding in vitro. Chemical Research in Toxicology, 14, 946-950.
  • Headlam, H., Lay, P. (2001). EPR spectroscopic studies of the reduction of chromium(VI) by methanol in the presence of peptides. Formation of long-lived chromium(V) peptide complexes. Inorganic Chemistry, 40, 78-86.
  • Cheng, M., Armstrong, R., Lay, P., Bae,, I., Tolmachev, Y., Mo,, Y., Scherson, D., Scheidt, W., Ellison,, M. (2001). In situ Fe K-edge X-ray absorption spectroscopy of a nitrosyl iron(II) porphyrin adduct adsorbed on a high-area carbon electrode in aqueous electrolytes. Inorganic Chemistry, 40, 3256-3258.
  • Morgan, Y., Turner, P., Kennedy, B., Hambley, T., Lay, P., Biffin, J., Regtop, H., Warwick, B. (2001). Preparation and characterization of dinuclear copper-indomethacin anti-inflammatory drugs. Inorganica Chimica Acta, 324, 150-161.
  • Codd, R., Dillon, C., Levina, A., Lay, P. (2001). Studies on the genotoxicity of chromium: From the test tube to the cell. Coordination Chemistry Reviews, 216-217(3), 537-582.
  • Codd, R., Levina, A., Zhang, L., Hambley, T., Lay, P. (2000). Characterization and X-ray absorption spectroscopic studies of bis[quinato(2)]oxochromate(V). Inorganic Chemistry, 39(5), 990-997.

Conferences

  • Levina, A., Aitken, J., Harris, H., McLeod, A., Lim, Z., Singharay, A., Pham, T., Safitri, A., Wu, L., Lay, P. (2009). Applications of X-ray absorption spectroscopy to the studies of metabolism of biologically active metal complexes. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
  • Lay, P. (2009). Complementary microprobe (X-ray, vibrational and fluorescence) spectroscopic techniques for understanding disease physiology and potential new treatments. 2009 Annual Scientifc Meeting, N/A: N/A.
  • Lay, P. (2009). Complementary vibrational spectroscopic and X-ray microprobe mapping/imaging in cellular biomedical studies. XAFS14, N/A: N/A.
  • Hackett, M., Carter, E., Lay, P. (2009). Hypoxia, micro blood vessels and cerebral malaria pathogenesis: New investigations using EPA-FTIR spectroscopic imaging. ICAVS5 2009, Australia: N/A.
  • Tarr, S., Carter, E., Whan, R., Levina, A., Tobin, M., Lay, P. (2009). Mapping and fluorescent imaging: Investigating the effects of fluorophores on intracellular biochemistry. International Conference on Advanced Vibrational Spectroscopy, N/A: N/A.
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging (Invited Lecture). 2nd Georgian Bay International Conference on Bioinorganic Chemistry, N/A.
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging. (Invited Lecture). Australian Microbeam Analysis Society, 10th Biennial Symposium, N/A.
  • Lee, J., Carter, E., Grau, G., Combes, V., Bonhoure, B., Lay, P. (2009). The investigation of monocyte cell signalling by FT-IR spectroscopy. International Conference on Advanced Vibrational Spectroscopy, N/A: N/A.
  • Glover, C., Mckinlay, J., Clift, M., Barg, B., Boldeman, J., Ridgway, M., Foran, G., Garrett, R., Lay, P., Broadbent, A. (2006). Status of the X-ray Absorption Spectroscopy (XAS) beamline at the Australian synchrotron. 13TH INTERNATIONAL CONFERENCE ON X-RAY ABSORPTION FINE STRUCTURE-XAFS13, on line: American Institute of Physics (AIP).
  • Raynor, B., Harris, H., Carter, E., Vogt, S., Cai, Z., Lai, B., Chin, C., Lee, Y., Lay, P., Witting, P. (2006). The use of synchrotron radiation to measure ion flux and cellular protein and lipid changes within cardiac ischemia reperfusion injury. XIV International Symposium on Atherosclerosis, Ireland: Elsevier Ireland Ltd.
  • Tam, K., Lay, P., Armstrong, R., Carter, E., Harris, H., Russell, P., Lee, K., Chen, C., Mountford, C. (2005). Characterisation of Ductal Carcinoma in situ Breast Cancer using IR Microspectroscopy. Incorporating a Four Day Workshop Series, Sydney: ACOVS6 Organising Committee.
  • Ali, M., Lay, P., Armstrong, R., Carter, E., Sorrell, T., Power, D. (2005). Fourier Transform Infrared (FT-IR) Spectroscopy for Identification and Differentiation of Fungi. Incorporating a Four Day Workshop Series, Sydney: ACOVS6 Organising Committee.
  • Wu, L., Carter, E., Harris, H., Lay, P., James, D., Lee, K., Chen, C. (2005). Measuring Myogenesis: A Case Study in a Biological Application of Synchrotron IR Spectroscopy. Incorporating a Four Day Workshop Series, Sydney: ACOVS6 Organising Committee.
  • Rich, A., Armstrong, R., Lay, P., Weiss, M., Mackay, J., Gell, D. (2005). Resonance Raman Scattering of alpha-hemoglobin Stabilising Protein. Incorporating a Four Day Workshop Series, Sydney: ACOVS6 Organising Committee.
  • Carter, E., Rich, A., Wu, L., Tam, K., Lay, P., Harris, H., Levina, A., Mulyana, Y., Stamfl, A., Chen, C., et al (2005). SR-FTIR Spectroscopy of Biological Samples at Beamline 14A NSRRC. Incorporating a Four Day Workshop Series, Sydney: ACOVS6 Organising Committee.
  • Hambley, T., Bonin, A., Davies, N., Dillon, C., Weder, J., Kennedy, B., Lay, P., Morgan, Y., Zhou, Q., Biffin, J., et al (2001). Metal complexes of non-steroidal anti-inflammatory drugs: An opportunity yet to be realised. 10th International Conference on Bioinorganic Chemistry, : Ads & Adea.
  • Dillon, C., Davies, N., Hambley, T., Kennedy, B., Lay, P., Zhou, Q., Stampfl, A., Cai, Z., Lai, B., Biffin, J., et al (2001). Micro-SRIXE and micro-XANES analysis of carcinogens and anti-inflammatory drugs in mammalian cells. 10th International Conference on Bioinorganic Chemistry, : Ads & Adea.

Patents

  • Hackett, M., Lay, P., Carter, E., Hunt, N., Grau, G., Gottlieb, D. (2010). Classification of biological samples using spectroscopic analysis. Patent No. WO2009AU01423 20091030.

2014

  • Levina, A., Lay, P. (2014). Influence of an anti-metastatic ruthenium(III) prodrug on extracellular protein-protein interactions: studies by bio-layer interferometry. Inorganic Chemistry Frontiers, 1(1), 44-48. [More Information]
  • Kong, S., Chan, B., Park, J., Hill, K., Aitken, J., Cottle, L., Farghaian, H., Cole, A., Lay, P., Sue, C., et al (2014). Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes alpha-Synuclein externalization via exosomes. Human Molecular Genetics, 23(11), 2816-2833. [More Information]
  • Levina, A., McLeod, A., Kremer, L., Aitken, J., Glover, C., Johannessen, B., Lay, P. (2014). Reactivity-activity relationships of oral anti-diabetic vanadium complexes in gastrointestinal media: an X-ray absorption spectroscopic study. Metallomics, 6(10), 1880-1888. [More Information]
  • Pham, T., Aitken, J., Levina, A., Lay, P. (2014). Solid-state structural studies of chromium(III) nicotinato nutritional supplements. Inorganic Chemistry, 53(19), 10685-10694. [More Information]
  • Aitken, J., Austin, C., Hunt, N., Ball, H., Lay, P. (2014). The Fe-heme structure of met-indoleamine 2,3-dioxygenase-2 determined by X-ray absorption fine structure. Biochemical and Biophysical Research Communications, 450(1), 25-29. [More Information]
  • Levina, A., McLeod, A., Lay, P. (2014). Vanadium speciation by XANES spectroscopy: A three-dimensional approach. Chemistry: A European Journal, 20(38), 12056-12060. [More Information]

2013

  • Dickson, C., Rich, A., D'Avigdor, W., Collins, D., Lowry, J., Mollan, T., Khandros, E., Olson, J., Weiss, M., Mackay, J., Lay, P., et al (2013). Alpha-hemoglobin-stabilizing protein (AHSP) perturbs the proximal heme pocket of oxy-alpha-hemoglobin and weakens the iron-oxygen bond. Journal of Biological Chemistry, 288(27), 19986-20001. [More Information]
  • Levina, A., Aitken, J., Gwee, Y., Lim, Z., Liu, M., Singharay, A., Wong, P., Lay, P. (2013). Biotransformations of anticancer ruthenium(III) complexes: An X-ray absorption spectroscopic study. Chemistry: A European Journal, 19(11), 3609-3619. [More Information]
  • Aitken, J., Shearer, E., Giles, N., Lai, B., Vogt, S., Reboucas, J., Batinic-Haberle, I., Lay, P., Giles, G. (2013). Intracellular targeting and pharmacological activity of the superoxide dismutase mimics MnTE-2-PyP(5+) and MnTnHex-2-PyP(5+) regulated by their porphyrin ring substituents. Inorganic Chemistry, 52(8), 4121-4123. [More Information]
  • Bartholomaus, R., Irwin, J., Shi, L., Meejoo Smith, S., Levina, A., Lay, P. (2013). Isolation, Characterization, and Nuclease Activity of Biologically Relevant Chromium(V) Complexes with Monosaccharides and Model Diols. Likely Intermediates in Chromium-Induced Cancers. Inorganic Chemistry, 52(8), 4282-4292. [More Information]
  • Lee, J., Siegele, R., Pastuovic, Z., Hackett, M., Hunt, N., Grau, G., Cohen, D., Lay, P. (2013). Light and heavy ion beam analysis of thin biological sections. Nuclear Instruments and Methods in Physics Research. Section B, 306, 129-133. [More Information]
  • Zeng, A., Bilek, M., McKenzie, D., Lay, P., Boo, J. (2013). Native oxides and their effect on electrochemical characteristics of ta-C:N films. Surface and Coatings Technology, 228(Supplement 1), S486-S489. [More Information]

2012

  • Hackett, M., Lee, J., El Assaad, F., McQuillan, J., Carter, E., Grau, G., Hunt, N., Lay, P. (2012). FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: General implications for disease neurochemistry. ACS Chemical Neuroscience, 3(12), 1017-1024. [More Information]
  • Aitken, J., Lay, P., Duong, T., Aran, R., Witting, P., Harris, H., Lai, B., Vogt, S., Giles, G. (2012). Synchrotron radiation induced X-ray emission studies of the antioxidant mechanism of the organoselenium drug ebselen. Journal of Biological Inorganic Chemistry, 17(4), 589-598. [More Information]
  • Bartholomaus, R., Harms, K., Levina, A., Lay, P. (2012). Synthesis and characterization of a chromium(V) cis-1,2-cyclohexanediolato complex: A model of reactive intermediates in chromium-induced cancers. Inorganic Chemistry, 51(21), 11238-11240. [More Information]
  • George, G., Pickering, I., Pushie, M., Nienaber, K., Hackett, M., Ascone, I., Hedman, B., Hodgson, K., Aitken, J., Levina, A., Lay, P., et al (2012). X-ray-induced photo-chemistry and X-ray absorption spectroscopy of biological samples. Journal of Synchrotron Radiation, 19(6), 875-886. [More Information]

2011

  • Hackett, M., McQuillan, J., El Assaad, F., Aitken, J., Levina, A., Cohen, D., Siegele, R., Carter, E., Grau, G., Hunt, N., Lay, P. (2011). Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis. The Analyst, 136(14), 2941-2952. [More Information]
  • Hackett, M., Siegele, R., El Assaad, F., McQuillan, J., Aitken, J., Carter, E., Grau, G., Hunt, N., Cohen, D., Lay, P. (2011). Investigation of the mouse cerebellum using STIM and μ-PIXE spectrometric and FTIR spectroscopic mapping and imaging. Nuclear Instruments and Methods in Physics Research. Section B, 269(20), 2260-2263. [More Information]
  • Levina, A., Lay, P. (2011). Metal-based anti-diabetic drugs: Advances and challenges. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 40(44), 11675-11686. [More Information]
  • Aitken, J., Levina, A., Lay, P. (2011). Studies on the Biotransformations and Biodistributions of Metal-Containing Drugs Using X-ray Absorption Spectroscopy. Current Topics in Medicinal Chemistry, 11(5), 553-571. [More Information]

2010

  • Liu, M., Lim, Z., Gwee, Y., Levina, A., Lay, P. (2010). Characterization of a ruthenium(III)/NAMI-A adduct with bovine serum albumin that exhibits a high anti-metastatic activity. Angewandte Chemie (International Edition), 49(9), 1661-1664. [More Information]
  • Hackett, M., Lay, P., Carter, E., Hunt, N., Grau, G., Gottlieb, D. (2010). Classification of biological samples using spectroscopic analysis. Patent No. WO2009AU01423 20091030.
  • Levina, A., Zhang, L., Lay, P. (2010). Formation and reactivity of chromium(V)-thiolato complexes: A model for the intracellular reactions of carcinogenic chromium(VI) with biological thiols. Journal of the American Chemical Society, 132(25), 8720-8731.
  • Finney, L., Chishti, Y., Khare, T., Giometti, C., Levina, A., Lay, P., Vogt, S. (2010). Imaging metals in proteins by combining electrophoresis with rapid X-ray fluorescence mapping. ACS Chemical Biology, 5(6), 577-587.
  • Bonin, A., Yanez, J., Fukuda, C., Teng, X., Dillon, C., Hambley, T., Lay, P., Davies, N. (2010). Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. Cancer Chemotherapy and Pharmacology, 66(4), 755-764. [More Information]
  • Carter, E., Rayner, B., McLeod, A., Wu, L., Marshall, C., Levina, A., Aitken, J., Witting, P., Lai, B., Cai, Z., Harris, H., Lay, P., et al (2010). Silicon nitride as a versatile growth substrate for microspectroscopic imaging and mapping of individual cells. Molecular BioSystems, 6(7), 1316-1322. [More Information]

2009

  • Levina, A., Aitken, J., Harris, H., McLeod, A., Lim, Z., Singharay, A., Pham, T., Safitri, A., Wu, L., Lay, P. (2009). Applications of X-ray absorption spectroscopy to the studies of metabolism of biologically active metal complexes. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
  • Aitken, J., Carter, E., Eastgate, H., Hackett, M., Harris, H., Levina, A., Lee, Y., Chen, C., Lai, B., Vogt, S., Lay, P. (2009). Biomedical applications of X-ray absorption and vibrational spectroscopic microscopies in obtaining structural information from complex systems. Radiation Physics and Chemistry, 79(2), 176-184.
  • Levina, A., Codd, R., Lay, P. (2009). Chromium in cancer and dietary supplements. In G. R. Hanson and L. J. Berliner (Eds.), Biological Magnetic Resonance: High Resolution EPR Applications to Metalloenzymes and Metals in Medicine, (pp. 551-579). NY, USA: Springer.
  • Lay, P. (2009). Complementary microprobe (X-ray, vibrational and fluorescence) spectroscopic techniques for understanding disease physiology and potential new treatments. 2009 Annual Scientifc Meeting, N/A: N/A.
  • Lay, P. (2009). Complementary vibrational spectroscopic and X-ray microprobe mapping/imaging in cellular biomedical studies. XAFS14, N/A: N/A.
  • Zeng, A., Bilek, M., McKenzie, D., Lay, P. (2009). Correlation of film structure and molecular oxygen reduction at nitrogen doped amorphous carbon thin film electrochemical electrodes. Diamond and Related Materials, 18(9), 1102-1108. [More Information]
  • Sargeson, A., Lay, P. (2009). Dependence of the properties of cobalt(III) cage complex as a function of the derivatization of amine substituents. Australian Journal of Chemistry: an international journal for chemical science, 62(10), 1280-1290.
  • Hackett, M., Carter, E., Lay, P. (2009). Hypoxia, micro blood vessels and cerebral malaria pathogenesis: New investigations using EPA-FTIR spectroscopic imaging. ICAVS5 2009, Australia: N/A.
  • Tarr, S., Carter, E., Whan, R., Levina, A., Tobin, M., Lay, P. (2009). Mapping and fluorescent imaging: Investigating the effects of fluorophores on intracellular biochemistry. International Conference on Advanced Vibrational Spectroscopy, N/A: N/A.
  • Duong, T., Witting, P., Antao, S., Parry, S., Kennerson, M., Lai, B., Vogt, S., Lay, P., Harris, H. (2009). Multiple protective activities of neuroglobin in cultured neuronal cells exposed to hypoxia re-oxygenation injury. Journal of Neurochemistry, 108(5), 1143-1154. [More Information]
  • Levina, A., Singharay, A., Lay, P. (2009). Recent developments in ruthenium anticancer drugs. Metallomics, 1(6), 458-470.
  • Harris, H., Vogt, S., Lay, P. (2009). Response to Guzzi & Pigattos Comments on Migration of mercury from dental amalgam through human teeth by H. H. Harris et al. (2008). J. Synchrotron Rad. 15, 123-128. Journal of Synchrotron Radiation, 16(3), 437-438.
  • Zeng, A., Bilek, M., McKenzie, D., Lay, P. (2009). Semiconductor properties and redox responses at a-C:N thin film electrochemical electrodes. Diamond and Related Materials, 18(10), 1211-1217. [More Information]
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging (Invited Lecture). 2nd Georgian Bay International Conference on Bioinorganic Chemistry, N/A.
  • Harris, H., Carter, E., Rayner, B., McLeod, A., Crossley, E., Levina, A., Munro, K., Aitken, J., Witting, P., Lai, B., Rendina, L., Lay, P., et al (2009). Silicon nitride as a universal substrate for microspectroscopic imaging. (Invited Lecture). Australian Microbeam Analysis Society, 10th Biennial Symposium, N/A.
  • Lee, J., Carter, E., Grau, G., Combes, V., Bonhoure, B., Lay, P. (2009). The investigation of monocyte cell signalling by FT-IR spectroscopy. International Conference on Advanced Vibrational Spectroscopy, N/A: N/A.
  • Carter, E., Tam, K., Armstrong, R., Lay, P. (2009). Vibrational spectroscopic mapping and imaging of tissues and cells. Biophysical Reviews, 1(2), 95-103. [More Information]

2008

  • Harris, H., Vogt, S., Eastgate, H., Lay, P. (2008). A link between copper and dental caries in human teeth identified by X-ray fluorescence elemental mapping. Journal of Biological Inorganic Chemistry, 13(2), 303-306. [More Information]
  • Chatterjee, D., Singharay, A., Levina, A., Lay, P. (2008). A potential role for protein tyrosine phosphatase inhibition by a Ru(III)-edta complex (edta = ethylenediaminetetraacetate) in its biological activity. Chemical Communications, 2008 (25), 2864-2866.
  • Levina, A., Lay, P. (2008). Chemical properties and toxicity of chromium(III) nutritional supplements. Chemical Research in Toxicology, 21(3), 563-571.
  • Zeng, A., Bilek, M., McKenzie, D., Lay, P., La Fontaine, A., Keast, V. (2008). Correlation between film structures and potential limits for hydrogen and oxygen evolutions at a-C:N film electrochemical electrodes. Carbon, 46(4), 663-670. [More Information]
  • Zeng, A., Bilek, M., McKenzie, D., Lay, P. (2008). Deposition of a-C:N films and evaluation of their robustness in electrochemical applications. Thin Solid Films, 516(16), 5231-5235.
  • Harris, H., Vogt, S., Eastgate, H., Legnini, D., Hornberger, B., Cai, Z., Lai, B., Lay, P. (2008). Migration of mercury from dental amalgam through human teeth. Journal of Synchrotron Radiation, 15(2), 123-128.
  • Nguyen, A., Mulyani, I., Levina, A., Lay, P. (2008). Reactivity of chromium(III) nutritional supplements in biological media: An X-ray absorption spectroscopic study. Inorganic Chemistry, 47(10), 4299-4309.

2007

  • Vogt, S., Lai, B., Finney, L., Palmer, B., Wu, L., Harris, H., Paunesku, T., de Jonge, M., Legnini, D., Maser, J., Lay, P., et al (2007). Imaging trace elements in cells with X-ray fluorescence microscopy. Microscopy and Microanalysis, 13((Suppl 2)), 40-41. [More Information]
  • Carter, E., Marshall, C., Ali, M., Ganendren, R., Sorrell, T., Wright, L., Lee, Y., Chen, C., Lay, P. (2007). Infrared Spectroscopy of Microorganisms: Characterization, Identification, and Differentiation. In Katrin Kneipp, Ricardo Aroca, Harald Kneipp and Edeline Wentrup-Byrne (Eds.), New Approaches in Biomedical Spectroscopy, (pp. 64-84). Washington DC, United States: American Chemical Society.
  • Thomas, S., Terentis, A., Cai, H., Takikawa, O., Levina, A., Lay, P., Freewan, M., Stocker, R. (2007). Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide. Journal of Biological Chemistry, 282(33), 23778-23787. [More Information]
  • Levina, A., McLeod, A., Seuring, J., Lay, P. (2007). Reactivity of potential anti-diabetic molybdenum(VI) complexes in biological media: A XANES spectroscopic study. Journal of Inorganic Biochemistry, 101(11-12), 1586-1593. [More Information]
  • Levina, A., Mulyani, I., Lay, P. (2007). Redox chemistry and biological activities of chromium(III) complexes. In J. B. Vincent (Eds.), The Nutritional Biochemistry of Chromium(III), (pp. 225-256). Amsterdam, Netherlands: Elsevier.
  • Levina, A., Harris, H., Lay, P. (2007). X-ray Absorption and EPR Spectroscopic Studies of the Biotransformations of Chromium(VI) in Mammalian Cells. Is Chromodulin an Artifact of Isolation Methods? Journal of the American Chemical Society, 129(5), 1065-1075.

2006

  • Levina, A., Harris, H., Lay, P. (2006). Binding of chromium(VI) to histones: implications for chromium(VI)-induced genotoxicity. Journal of Biological Inorganic Chemistry, 11(2), 225-234. [More Information]
  • Milsmann, C., Levina, A., Harris, H., Foran, G., Turner, P., Lay, P. (2006). Charge distribution in chromium and vanadium catecholato complexes: X-ray absorption spectroscopic and computational studies. Inorganic Chemistry, 45(12), 4743-4754.
  • Codd, R., Lay, P., Tsibakhashvili, N., Kalabegishvili, T., Murusidze, I., Holman, H. (2006). Chromium(V) complexes generated in Arthrobacter oxydans by simulation analysis of EPR spectra. Journal of Inorganic Biochemistry, 100(11), 1827-1833. [More Information]
  • Armstrong, R., Foran, G., Hough, W., D'Alessandro, D., Lay, P., Crossley, M. (2006). Spectroelectrochemical evidence for communication within a laterally-bridged dimanganese(III) bis-porphyrin. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2006 (40), 4805-4813.
  • Glover, C., Mckinlay, J., Clift, M., Barg, B., Boldeman, J., Ridgway, M., Foran, G., Garrett, R., Lay, P., Broadbent, A. (2006). Status of the X-ray Absorption Spectroscopy (XAS) beamline at the Australian synchrotron. 13TH INTERNATIONAL CONFERENCE ON X-RAY ABSORPTION FINE STRUCTURE-XAFS13, on line: American Institute of Physics (AIP).
  • Shi, L., Jing, H., Ren, G., Levina, A., Lay, P. (2006). Studies on the mechanism of Cr-induced DNA damage in glucose and its derivative. Weisheng Yanjiu, 35, 348-351.
  • Witting, P., Harris, H., Rayner, B., Aitken, J., Dillon, C., Stocker, R., Lai, B., Cai, Z., Lay, P. (2006). The Endothelium-Derived Hyperpolarizing Factor, H-2O-2, Promotes Metal-Ion Efflux in Aortic Endothelial Cells: Elemental Mapping by a Hard X-ray Microprobe. Biochemistry, 45(41), 12500-12509. [More Information]
  • Raynor, B., Harris, H., Carter, E., Vogt, S., Cai, Z., Lai, B., Chin, C., Lee, Y., Lay, P., Witting, P. (2006). The use of synchrotron radiation to measure ion flux and cellular protein and lipid changes within cardiac ischemia reperfusion injury. XIV International Symposium on Atherosclerosis, Ireland: Elsevier Ireland Ltd.

2005

  • Immoos, C., Sulc, F., Farmer, P., Czarnecki, K., Bocian, D., Levina, A., Aitken, J., Armstrong, R., Lay, P. (2005). Bonding in HNO-myoglobin as characterized by X-ray absorption and resonance Raman spectroscopies. Journal of the American Chemical Society, 127(3), 814-815.
  • Tam, K., Lay, P., Armstrong, R., Carter, E., Harris, H., Russell, P., Lee, K., Chen, C., Mountford, C. (2005). Characterisation of Ductal Carcinoma in situ Breast Cancer using IR Microspectroscopy. Incorporating a Four Day Workshop Series, Sydney: ACOVS6 Organising Committee.
  • Mactier, S., Luxenhofer, R., Levina, A., Codd, R., Lay, P. (2005). Chromium(V) complexes of hydroxamic acids: Formation, structures, and reactivities. Inorganic Chemistry, 44(8), 2934-2943. [More Information]
  • Barnard, P., Levina, A., Lay, P. (2005). Chromium(V) peptide complexes: Synthesis and spectroscopic characterization. Inorganic Chemistry, 44(4), 1044-1053.
  • Ali, M., Lay, P., Armstrong, R., Carter, E., Sorrell, T., Power, D. (2005). Fourier Transform Infrared (FT-IR) Spectroscopy for Identification and Differentiation of Fungi. Incorporating a Four Day Workshop Series, Sydney: ACOVS6 Organising Committee.
  • Wu, L., Carter, E., Harris, H., Lay, P., James, D., Lee, K., Chen, C. (2005). Measuring Myogenesis: A Case Study in a Biological Application of Synchrotron IR Spectroscopy. Incorporating a Four Day Workshop Series, Sydney: ACOVS6 Organising Committee.
  • Levina, A., Lay, P. (2005). Mechanistic studies of relevance to the biological activities of chromium. Coordination Chemistry Reviews, 249(3-4), 281-298. [More Information]
  • Ramadan, S., Bonin, A., Kennedy, B., Hambley, T., Lay, P. (2005). Nuclear magnetic resonance analysis of indomethacin-induced gastric ulcers. Chemical Research in Toxicology, 18(2), 123-128.
  • Rich, A., Armstrong, R., Lay, P., Weiss, M., Mackay, J., Gell, D. (2005). Resonance Raman Scattering of alpha-hemoglobin Stabilising Protein. Incorporating a Four Day Workshop Series, Sydney: ACOVS6 Organising Committee.
  • Carter, E., Rich, A., Wu, L., Tam, K., Lay, P., Harris, H., Levina, A., Mulyana, Y., Stamfl, A., Chen, C., et al (2005). SR-FTIR Spectroscopy of Biological Samples at Beamline 14A NSRRC. Incorporating a Four Day Workshop Series, Sydney: ACOVS6 Organising Committee.
  • Signorella, S., Garcia, S., Rizzotto, M., Levina, A., Lay, P., Sala, L. (2005). The EPR pattern of Cr-V complexes of D-ribose derivatives. Polyhedron, 24(9), 1079-1085.
  • Levina, A., Armstrong, R., Lay, P. (2005). Three-dimensional structure determination using multiple-scattering analysis of XAFS: applications to metalloproteins and coordination chemistry. Coordination Chemistry Reviews, 249(1-2), 141-160. [More Information]
  • Harris, H., Levina, A., Dillon, C., Mulyana, Y., Lai, B., Cai, Z., Lay, P. (2005). Time-dependent uptake, distribution and biotransformation of chromium(VI) in individual and bulk human lung cells: application of synchrotron radiation techniques. Journal of Biological Inorganic Chemistry, 10(2), 105-118. [More Information]

2004

  • Mulyani, I., Levina, A., Lay, P. (2004). Biomimetic Oxidation Of Chromium(III): Does The Antidiabetic Activity Of Chromium(III) Involve Carcinogenic Chromium(VI)? Angewandte Chemie (International Edition), 43(34), 4504-4507. [More Information]
  • Lay, P., Levina, A. (2004). Chromium. In A. G. Webb (Eds.), Comprehensive Coordination Chemistry II : From Biology to Nanotechnology [Volume 4: Transition Metal Groups 3-6], (pp. 313-413). Amsterdam: Pergamon Elsevier.
  • Dillon, C., Hambley, T., Kennedy, B., Lay, P., Weder, J., Zhou, Q. (2004). Copper And Zinc Complexes As Antiinflammatory Drugs. In Astrid Sigel & Helmut Sigel (Eds.), Metal Ions in Biological Systems : Volume 41 : Metal Ions and their Complexes in Medication, (pp. 253-277). New York: Marcel Dekker.
  • Aitken, J., Thomas, S., Stocker, R., Thomas, S., Takikawa, O., Armstrong, R., Lay, P. (2004). Determination Of The Nature Of The Heme Environment In Nitrosyl Indoleamine 2,3-Dioxygenase Using Multiple-Scattering Analyses Of X-Ray Absorption Fine Structure. Biochemistry, 43(17), 4892-4898.
  • Feng, L., Gell, D., Zhou, S., Gu, L., Kong, Y., Li, J., Hu, M., Yan, N., Lee, C., Rich, A., Armstrong, R., Lay, P., Mackay, J., et al (2004). Molecular Mechanism Of AHSP-Mediated Stabilization Of A-Hemoglobin. Cell, 119(5), 629-640.
  • Ramadan, S., Hambley, T., Kennedy, B., Lay, P. (2004). Nmr Spectroscopic Characterization Of Copper(Ii) And Zinc(Ii) Complexes Of Indomethacin. Inorganic Chemistry, 43(9), 2943-2946.
  • Li, J., Sun, Z., Zhu, X., Zeng, H., Xu, Z., Wang, Z., lin, J., Huang, W., Armstrong, R., Lay, P. (2004). Optical Bistability For Zno-Nb2O5-Teo2 Glasses. Optical Materials, 25(4), 401-405.
  • Rayner, B., Stocker, R., Lay, P., Witting, P. (2004). Regio- And Stereo-Chemical Oxidation Of Linoleic Acid By Human Myoglobin And Hydrogen Peroxide: Tyr(103) Affects Rate And Product Distribution. Biochemical Journal, 381(2), 365-372.
  • Levina, A., Lay, P. (2004). Solution Structures Of Chromium(Vi) Complexes With Glutathione And Model Thiols. Inorganic Chemistry, 43(1), 324-335.
  • Weeks, C., Levina, A., Dillon, C., Turner, P., Fenton, R., Lay, P. (2004). Synthesis And Characterization Of A Chromium(V) Cis-Dioxo Bis(1,10-Phenanthroline) Complex And Crystal Molecular Structures Of Its Chromium(Iii) Precursor. Inorganic Chemistry, 43(24), 7844-7856.
  • Anderberg, P., Harding, M., Lay, P. (2004). The Effect Of Metal Ions On The Electrochemistry Of The Antitumor Antibiotic Streptonigrin. Journal of Inorganic Biochemistry, 98(5), 720-726. [More Information]
  • Gallagher, S., Thompson, K., Armstrong, R., Lay, P. (2004). The Unusual Intensity Behavior Of The 281-Cm(-1) Resonance Raman Band Of C-60: A Complex Tale Of Vibronic Coupling, Symmetry Reduction, Solvatochromism, And Jahn - Teller Activity. The Journal of Physical Chemistry Part A: Molecules, Spectroscopy, Kinetics, Environment and General Theory, 108(26), 5564-5572.
  • Levina, A., Foran, G., Pattison, D., Lay, P. (2004). X-Ray Absorption Spectroscopic And Electrochemical Studies Of Tris(Catecholato (2-))Chromate (V/I V/Iii) Complexes. Angewandte Chemie (International Edition), 43(4), 462-465. [More Information]
  • Levina, A., Codd, R., Foran, G., Hambley, T., Maschmeyer, T., Masters, A., Lay, P. (2004). X-Ray Absorption Spectroscopic Studies Of Chromium(V/Iv/Iii)2-Ethyl-2-Hydroxybutanoato(2-/1-) Complexes. Inorganic Chemistry, 43(3), 1046-1055.

2003

  • Beattie, J., Beck, C., Lay, P., Masters, A. (2003). Chemistry of cobalt acetate. 7. Electrochemical oxidation of mu3-oxo-centered cobalt(III) acetate trimers. Inorganic Chemistry, 42(25), 8366-8370.
  • Levina, A., Codd, R., Dillon, C., Lay, P. (2003). Chromium in Biology: Toxicology and Nutritional aspects. In Karlin, Kenneth D (Eds.), Progress in Inorganic Chemistry, Volume 51, (pp. 145-250). Hoboken: John Wiley & Sons.
  • Mulyani, I., Levina, A., Lay, P. (2003). Chromium(III) complexes used as nutritional supplements: structures and reactivities. Journal of Inorganic Biochemistry, 961, 196.
  • Dillon, C., Hambley, T., Kennedy, B., Lay, P., Zhou, Q., Davies, N., Biffen, R., Regtop, H. (2003). Gastrointestinal Toxicity, Antiinflammatory Activity, and Superoxide Dismutase Activity of Copper and Zinc Complexes of the Antiinflammatory Drug Indomethacin. Chemical Research in Toxicology, 16(1), 28-37.
  • Dillon, C., Kennedy, B., Lay, P., Lai, B., Cai, Z., Stampfl, A., Ilinski, P., Legnini, D., Maser, J., Rodrigues, W., et al (2003). Implementation of X-ray microscopy and micro-XANES analysis for investigations of the cellular uptake and cellular metabolism of transition metals. Journal de Physique IV (France), 104, 293-296.
  • Codd, R., Lay, P. (2003). Oxochromium(V) species formed with 2,3-dehydro-2-deoxy-N-acetylneuraminic or N-acetylneuraminic (Sialic) acids: an in vitro model system of oxochromium(V) species potentially stabilized in the respiratory tract upon inhalation of carcinogenic chromium(VI). Chemical Research in Toxicology, 16(7), 881-892.
  • Codd, R., Irwin, J., Lay, P. (2003). Sialoglycoprotein and carbohydrate complexes in chromium toxicity. Current Opinion In Chemical Biology, 7, 213-219.
  • Levina, A., Zhang, L., Lay, P. (2003). Structure and reactivity of a chromium(V) glutathione complex. Inorganic Chemistry, 42(3), 767-784.
  • Cawich, C., Ibrahim, A., Link, K., Bumgartner, A., Patro, M., Mahapatro, S., Lay, P., Levina, A., Eaton, S., Eaton, G. (2003). Synthesis of a pyridinium bis[citrato(2-)]oxochromate(V) complex and its ligand-exchange reactions. Inorganic Chemistry, 42(20), 6458-6468.
  • Kim, K., Hauke, F., Hirsch, A., Boyd, P., Carter, E., Armstrong, R., Lay, P., Reed, C. (2003). Synthesis of the C59N+ carbocation. A monomeric azafullerene isoelectronic to C60. Journal of the American Chemical Society, 125(14), 4024-4025.
  • Levina, A., Turner, P., Lay, P. (2003). X-ray absorption spectroscopic studies of chromium nitroso complexes. Crystal and molecular strucute of (Ph4P)3[Cr(NO)(NCS)5].2.4(Ch3)2CO. Inorganic Chemistry, 42(17), 5392-5398.
  • Zhou, Q., Hambley, T., Kennedy, B., Lay, P. (2003). XAFS studies of anti-inflammatory dinuclear and mononuclear Zn(II) complexes of indomethacin. Inorganic Chemistry, 42(25), 8557-8566.

2002

  • Weder, J., Dillon, C., Hambley, T., Kennedy, B., Lay, P., Biffin, J., Regtop, H., Davies, N. (2002). Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized. Coordination Chemistry Reviews, 232(1-2), 95-126.
  • Dillon, C., Lay, P., Kennedy, B., Stampfl, A., Cai, Z., Ilinski, P., Rodrigues, W., Legnini, D., Lai, B., Maser, J. (2002). Hard X-ray microprobe studies of chromium(VI)-treated V79 Chinese hamster lung cells: intracellular mapping of the biotransformation products of a chromium carcinogen. Journal of Biological Inorganic Chemistry, 7, 640-645. [More Information]
  • Weeks, C., Turner, P., Fenton, R., Lay, P. (2002). Nickel(II) complexes with amide ligands: oxidative dehydrogenation of the amines in a tetradentate diamide-diamine ligand. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 10(6), 931-940.
  • Rizzotto, M., Levina, A., Santoro, M., García, S., Frascaroli, M., Signorella, S., Sala, L., Lay, P. (2002). Redox and ligand-exchange chemistry of chromium(VI/V)-methyl glycoside systems. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, , 3206-3213.
  • Witting, P., Mauk, A., Lay, P. (2002). Role of Tyrosine-103 in Myoglobin Peroxidase Activity: Kinetic and Steady-State Studies on the Reaction of Wild-Type and Variant Recombinant Human Myoglobins with H2O2. Biochemistry, 41(38), 11495-11503.

2001

  • Pattison, D., Levina, A., Lay, P., Davies, M. (2001). An investigation of the chromium oxidation state of a monoanionic chromium tris(catecholate) complex by X-ray absorption and EPR spectroscopies. Inorganic Chemistry, 40, 214-217.
  • Codd, R., Lay, P. (2001). Chromium(V)-sialic (neuraminic) acid species are formed from mixtures of chromium(VI) and saliva. Journal of the American Chemical Society, 123, 11799-11800.
  • Pattison, D., Levina, A., Lay, P., Davies, M., Dixon, N. (2001). Chromium(VI) reduction by catechol(amine)s results in DNA cleavage in vitro: Relevance to chromium genotoxicity. Chemical Research in Toxicology, 14, 500-510.
  • Weder, J., Hambley, T., Kennedy, B., Lay, P., Rich, A., Foran, G. (2001). Determination of the structures of antiinflammatory copper(II) dimers of indomethacin by multiple-scattering analyses of X-ray absorption fine structure data. Inorganic Chemistry, 40, 1295-1302.
  • Headlam, H., Weeks, C., Turner, P., Hambley, T., Lay, P. (2001). Dinuclear chromium(V) amino acid complexes from the reduction of chromium(VI) in the presence of amino acid ligands: XAFS characterization of a chromium(V) amino acid complex. Inorganic Chemistry, 40, 5097-5105.
  • Levina, A., Lay, P., Dixon, N. (2001). Disproportionation of a model chromium(V) complex causes extensive chromium(III)-DNA binding in vitro. Chemical Research in Toxicology, 14, 946-950.
  • Headlam, H., Lay, P. (2001). EPR spectroscopic studies of the reduction of chromium(VI) by methanol in the presence of peptides. Formation of long-lived chromium(V) peptide complexes. Inorganic Chemistry, 40, 78-86.
  • Cheng, M., Armstrong, R., Lay, P., Bae,, I., Tolmachev, Y., Mo,, Y., Scherson, D., Scheidt, W., Ellison,, M. (2001). In situ Fe K-edge X-ray absorption spectroscopy of a nitrosyl iron(II) porphyrin adduct adsorbed on a high-area carbon electrode in aqueous electrolytes. Inorganic Chemistry, 40, 3256-3258.
  • Hambley, T., Bonin, A., Davies, N., Dillon, C., Weder, J., Kennedy, B., Lay, P., Morgan, Y., Zhou, Q., Biffin, J., et al (2001). Metal complexes of non-steroidal anti-inflammatory drugs: An opportunity yet to be realised. 10th International Conference on Bioinorganic Chemistry, : Ads & Adea.
  • Dillon, C., Davies, N., Hambley, T., Kennedy, B., Lay, P., Zhou, Q., Stampfl, A., Cai, Z., Lai, B., Biffin, J., et al (2001). Micro-SRIXE and micro-XANES analysis of carcinogens and anti-inflammatory drugs in mammalian cells. 10th International Conference on Bioinorganic Chemistry, : Ads & Adea.
  • Morgan, Y., Turner, P., Kennedy, B., Hambley, T., Lay, P., Biffin, J., Regtop, H., Warwick, B. (2001). Preparation and characterization of dinuclear copper-indomethacin anti-inflammatory drugs. Inorganica Chimica Acta, 324, 150-161.
  • Codd, R., Dillon, C., Levina, A., Lay, P. (2001). Studies on the genotoxicity of chromium: From the test tube to the cell. Coordination Chemistry Reviews, 216-217(3), 537-582.

2000

  • Codd, R., Levina, A., Zhang, L., Hambley, T., Lay, P. (2000). Characterization and X-ray absorption spectroscopic studies of bis[quinato(2)]oxochromate(V). Inorganic Chemistry, 39(5), 990-997.

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