Professor Richard Payne
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Professor Richard Payne

FAA, FRSC, FRSN, FRACI; BSc Canterbury; PhD Cambridge
Professor of Organic Chemistry and Chemical Biology
NHMRC Investigator Leadership Fellow
Deputy Director, ARC Centre of Excellence for Innovations in Peptide and Protein Science
Professor Richard Payne

Richard J. Payne FAA graduated with 1st class honours from the University of Canterbury, New Zealand in 2002. In 2003, he was awarded a Gates Scholarship to undertake his PhD at the University of Cambridge under the supervision of the late Professor Chris Abell FRS FMedSci. After his PhD, Richard moved to The Scripps Research Institute under the auspices of a Lindemann Postdoctoral Fellowship where he worked in the laboratory of Professor Chi-Huey Wong. In 2008, he was recruited to the University of Sydney as a Lecturer of Organic within the School of Chemistry. Since 2015 he has held the position as Professor of Organic Chemistry and Chemical Biology and since 2020 has been a NHMRC Investigator Leadership Fellow and Deputy Director of the ARC Centre of Excellence for Innovations in Peptide and Protein Science. Prof. Payne’s research focuses on the design and synthesis of complex biomolecules with a view to addressing important problems in biology and medicine. His lab is recognized for pioneering a number of technologies for the assembly of large polypeptides and proteins by chemical synthesis. These methods have underpinned the discovery of modified peptide and protein drug leads for a range of diseases including anti-inflammatories, anti-thrombotics and anti-infectives. His research has been recognized by a number of awards including the Prime Minister’s Prize for Physical Scientist of the Year, HG Smith Medal and the AJ Birch Medal and election to the Australian Academy of Science.

Research in my group is focussed on utilising the tools of chemistry to address problems of biochemical and medicinal significance. Projects are multidisciplinary in nature, involving a combination of solution- and solid-phase organic synthesis, computer-aided drug discovery, compound screening technologies. Current projects include:

  • Rational design, synthesis and evaluation of new anti-infectives. More specifically, we are developing inhibitors that target novel pathways operating in pathogenic bacteria e.g. Mycobacterium tuberculosis (cause of TB), parasitic organisms e.g. Plasmodium falciparum (cause of malaria) and viruses, including SARS-CoV-2 (COVID-19).
  • Total synthesis of glycopeptides and glycoproteins of therapeutic interest.
  • Development of synthetic vaccines for cancer and infectious diseases.
  • Bioactive natural product total synthesis

For current research activities and opportunities please visit our home page at https://payneresearchgroup.com/

For details on the ARC Centre of Excellence for Innovations in Peptide and Protein Science see https://cipps.org.au/

Fellow of the Australian Academy of Science

Fellow of the Royal Society of Chemistry

Fellow of the Royal Australian Chemical Institute

Fellow of the Royal Society of New South Wales

Chair of the Australian Peptide Association

  • 2008 Royal Australian Chemical Institute Biota Medal for Medicinal Chemistry
  • 2010 New South Wales Young Tall Poppy Award
  • 2011 Rennie Memorial Medal
  • 2012 RACI Organic Chemistry Division Athel Beckwith lectureship
  • 2013 Tregear Award in Peptide Science
  • 2013 ARC Future Fellowship
  • 2014 Le Fèvre Memorial Prize
  • 2014 Edgeworth David Medal
  • 2015 MedChemComm Emerging Investigator Lectureship
  • 2015 Leo Dintenfass Memorial Award for Excellence in Research
  • 2015 Chemical Society of Japan Distinguished Lectureship Award
  • 2016 The Malcolm McIntosh Prime Minister's Prize for Physical Scientist of the Year
  • 2017 Vice Chancellor's Award for Research Excellence
  • 2018 Faculty of Science Learning and Teaching Award for Outstanding Higher Degree Supervision
  • 2018 A. J. Birch Medal
  • 2019 IUPAC Periodic Table of Younger Chemists (Selenium)
  • 2019 H. G. Smith Memorial Medal
  • 2021 Vice Chancellor's Award for outstanding higher degree supervision
  • 2022 Liversidge Lectureship
  • 2023 Elected as fellow od the Australian Academy of Science
  • 2024 Periscope award
Project titleResearch student
Synthesis of Diverse Anti-inflammatory SulfoproteinsAnthony AYOUB
Engineering Macrocyclic Sulfopeptides to become LYTACsBernardo CAVALLAZZI SEBOLD
Lysosome-targeting Chimaeras for Extracellular Protein DegradationBeiyuan CUI
Development of antimycobacterial cyclic peptides targeting the Clp proteolytic machineryBryton FORSTER
Development of drug carriers by using lipid nanoparticles and protein condensatesJordan KAMBANIS
Exploring the Sulfoproteome using Synthethic SulfoproteinsSebastian LOPEZ
Greening the production of peptides and proteinsAyman RACHID
Metal Extrusion Assays as a tool for Sulfate recognition in aqueous mediaGabrielle SHIELS
Proteolytically stable cyclic peptide drug discovery using mirror-image mRNA displayBelinda ZHANG

Publications

Book Chapters

  • Watson, E., Malins, L., Payne, R. (2021). Expanding Native Chemical Ligation Methodology with Synthetic Amino Acid Derivatives. In Ashraf Brik, Philip Dawson, Lei Liu (Eds.), Total Chemical Synthesis of Proteins, (pp. 119-159). Weinheim: Wiley-VCH. [More Information]
  • Malins, L., Payne, R. (2015). Modern Extensions of Native Chemical Ligation for Chemical Protein Synthesis. In Lei Liu (Eds.), Protein Ligation and Total Synthesis I, (pp. 27-87). Cham: Springer. [More Information]
  • Bennett, C., Payne, R., Koeller, K., Wong, C. (2008). Biologically relevant glycopeptides: Synthesis and applications. In Bertram O Fraser-Reid, Kuniaki Tatsuta, Joachim Thiem (Eds.), Glycoscience. Chemistry and Chemical Biology, (pp. 1795-1857). New York, USA: Springer.

Journals

  • Hao, H., Yuan, Y., Ito, A., Eberand, B., Tjondro, H., Cielesh, M., Norris, N., Moreno, C., Maxwell, J., Neely, G., Payne, R., Kebede, M., Larance, M., et al (2025). FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains. Nature Chemical Biology. [More Information]
  • Chernykh, A., Woods, R., Thaysen-Andersen, M., Abrahams, J., Grant, O., Kambanis, L., Sumer-Bayraktar, Z., Ugonotti, J., Kawahara, R., Corcilius, L., Payne, R. (2024). Position-specific N- and O-glycosylation of the reactive center loop impacts neutrophil elastase–mediated proteolysis of corticosteroid-binding globulin. Journal of Biological Chemistry, 300(1), 105519. [More Information]
  • Devkota, S., Aryal, P., Wilce, M., Payne, R., Stone, M., Bhusal, R. (2024). Structural basis of chemokine recognition by the class A3 tick evasin EVA-ACA1001. Protein Science, 33(6), e4999. [More Information]

Conferences

  • Fernandes, K., Deplazes, E., Payne, R., Carter, D. (2021). Lactoferrin & lactofungin as antifungal synergents. 15th International Conference on Lactoferrin Structure, Function & Applications .
  • Payne, R. (2009). Inhibition of Shikimate pathway enzymes as novel antibacterial leads (Biota Medal Lecture). 7th AFMC International Medicinal Chemistry Symposium, Cairns.
  • Payne, R. (2009). Ligation-based assembly of glycopeptides and glycoproteins. Seminar, School of Chemistry, Monash University, N/A: N/A.

Patents

  • Payne, R., Jackson, S. (2021). Novel Antithrombotics for Safer Stroke Therapy. Patent No. 11091535, 2017376839.
  • Payne, R., Thompson, R. (2019). Peptide Ligation with Selective Desulfurization. Patent No. 3004134. , Belgium, Denmark, France, Germany, Ireland, Luxembourg, Monaco, Switzerland, United Kingdom.

2025

  • Hao, H., Yuan, Y., Ito, A., Eberand, B., Tjondro, H., Cielesh, M., Norris, N., Moreno, C., Maxwell, J., Neely, G., Payne, R., Kebede, M., Larance, M., et al (2025). FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains. Nature Chemical Biology. [More Information]

2024

  • Chernykh, A., Woods, R., Thaysen-Andersen, M., Abrahams, J., Grant, O., Kambanis, L., Sumer-Bayraktar, Z., Ugonotti, J., Kawahara, R., Corcilius, L., Payne, R. (2024). Position-specific N- and O-glycosylation of the reactive center loop impacts neutrophil elastase–mediated proteolysis of corticosteroid-binding globulin. Journal of Biological Chemistry, 300(1), 105519. [More Information]
  • Devkota, S., Aryal, P., Wilce, M., Payne, R., Stone, M., Bhusal, R. (2024). Structural basis of chemokine recognition by the class A3 tick evasin EVA-ACA1001. Protein Science, 33(6), e4999. [More Information]
  • Patel, K., Jiramongkol, Y., Norman, A., Maxwell, J., Mohanty, B., Payne, R., Cook, K., White, M. (2024). The enzymatic oxygen sensor cysteamine dioxygenase binds its protein substrates through their N-termini. Journal of Biological Chemistry, 300(9), 107653. [More Information]

2023

  • Thijssen, V., Vermeir, S., Liu, M., Li, W., Chatziandreou, M., Donselaar, T., Du, W., Drulyte, I., Bosch, B., Snijder, J., Payne, R., Franck, C., Norman, A., et al (2023). A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein. Proceedings of the National Academy of Sciences of the United States of America, 120(26), e2303292120. [More Information]
  • Vigder, N., Suarna, C., Corcilius, L., Nadel, J., Chen, W., Payne, R., Tumanov, S., Stocker, R. (2023). An improved method for the detection of myeloperoxidase chlorinating activity in biological systems using the redox probe hydroethidine. Free Radical Biology and Medicine, 195, 23-35. [More Information]
  • Tran, P., Schroeder, C., Tran, H., McMahon, K., Deuis, J., Ragnarsson, L., Norman, A., Sharpe, S., Payne, R., Vetter, I. (2023). Changes in Potency and Subtype Selectivity of Bivalent NaV Toxins are Knot-Specific. Bioconjugate Chemistry, 34(6), 1072-1083. [More Information]

2022

  • Johansen-Leete, J., Ullrich, S., Fry, S., Frkic, R., Bedding, M., Aggarwal, A., Ashhurst, A., Ekanayake, K., Mahawaththa, M., Mini Sasi, V., Ford, D., Passioura, T., Larance, M., Payne, R., et al (2022). Antiviral cyclic peptides targeting the main protease of SARS-CoV-2. Chemical Science, (13), 3826-3836. [More Information]
  • Hanna, C., Kriegesmann, J., Dowman, L., Becker, C., Payne, R. (2022). Chemical Synthesis and Semisynthesis of Lipidated Proteins. Angewandte Chemie - International Edition, 61(15), e202111266. [More Information]
  • MacKay, A., Payne, R., Malins, L. (2022). Electrochemistry for the Chemoselective Modification of Peptides and Proteins. Journal of the American Chemical Society, 144(1), 23-41. [More Information]

2021

  • Robinson, S., Kambanis, L., Clayton, D., Hinneburg, H., Corcilius, L., Mueller, A., Walker, A., Keramidas, A., Kulkarni, S., Jones, A., Payne, R., et al (2021). A pain-causing and paralytic ant venom glycopeptide. iScience, 24(10), 103175. [More Information]
  • Patel, K., Solomon, P., Walshe, J., Ford, D., Wilkinson-White, L., Payne, R., Low, J., Mackay, J. (2021). BET-Family Bromodomains Can Recognize Diacetylated Sequences from Transcription Factors Using a Conserved Mechanism. Biochemistry, 60(9), 648-662. [More Information]
  • Premdjee, B., Andersen, A., Larance, M., Conde-Frieboes, K., Payne, R. (2021). Chemical Synthesis of Phosphorylated Insulin-like Growth Factor Binding Protein 2. Journal of the American Chemical Society, 143(14), 5336-5342. [More Information]

2020

  • Zhong, Y., Paudel, B., Ryan, D., Low, J., Franck, C., Patel, K., Bedward, M., Torrado, M., Payne, R., Van Oijen, A., Mackay, J. (2020). CHD4 slides nucleosomes by decoupling entry- and exit-side DNA translocation. Nature Communications, 11(1), 1519. [More Information]
  • Clayton, D., Kulkarni, S., Sayers, J., Dowman, L., Ripoll-Rozada, J., Barbosa Pereira, P., Payne, R. (2020). Chemical Synthesis of a Haemathrin Sulfoprotein Library Reveals Enhanced Thrombin Inhibition Following Tyrosine Sulfation. RSC Chemical Biology, 2020 (1), 379-384. [More Information]
  • Patel, K., Walport, L., Walshe, J., Solomon, P., Low, J., Tran, D., Mouradian, K., Silva, A., Wilkinson-White, L., Norman, A., Franck, C., Matthews, J., Guss, M., Payne, R., Passioura, T., Mackay, J., et al (2020). Cyclic peptides can engage a single binding pocket through highly divergent modes. Proceedings of the National Academy of Sciences of the United States of America, 117(43), 26728-26738. [More Information]

2019

  • Pinto, M., Ripoll-Rozada, J., Ramos, H., Watson, E., Franck, C., Payne, R., Saraiva, L., Barbosa Pereira, P., Pastore, A., Rocha, F., et al (2019). A simple linearization method unveils hidden enzymatic assay interferences. Biophysical Chemistry, 252, 1-15. [More Information]
  • Wei, R., Liu, H., Tang, A., Payne, R., Li, X. (2019). A solution to chemical pseudaminylation via a bimodal glycosyl donor for highly stereocontrolled alpha- and beta-glycosylation. Organic Letters, 21(10), 3584-3588. [More Information]
  • Kulkarni, S., Watson, E., Premdjee, B., Conde-Frieboes, K., Payne, R. (2019). Diselenide-selenoester ligation for chemical protein synthesis. Nature Protocols, 14(7), 2229-2257. [More Information]

2018

  • Robinson, S., Mueller, A., Clayton, D., Starobova, H., Hamilton, B., Payne, R., Vetter, I., King, G., Undheim, E. (2018). A comprehensive portrait of the venom of the giant red bull ant, Myrmecia glulosa, reveals a hyperdiverse hymenopteran toxin gene family. Science Advances, 4(9), 1-12. [More Information]
  • Payne, R. (2018). Bioactive molecules Australasia. Tetrahedron, 74(12), 1165-1166. [More Information]
  • Imin, N., Patel, N., Corcilius, L., Payne, R., Djordjevic, M. (2018). CLE peptide tri-arabinosylation and peptide domain sequence composition are essential for SUNN-dependent autoregulation of nodulation in Medicago truncatula. New Phytologist, 218(1), 73-80. [More Information]

2017

  • Mitchell, N., Sayers, J., Kulkarni, S., Clayton, D., Goldys, A., Ripoll-Rozada, J., Barbosa Pereira, P., Chan, B., Radom, L., Payne, R. (2017). Accelerated protein synthesis via one-pot ligation-deselenization chemistry. Chem, 2(5), 703-715. [More Information]
  • Corcilius, L., Hastwell, A., Zhang, M., Williams, J., Mackay, J., Gresshoff, P., Ferguson, B., Payne, R. (2017). Arabinosylation modulates the growth-regulating activity of the peptide hormone CLE40a from soybean. Cell Chemical Biology, 24(11), 1347-1355.e7. [More Information]
  • Phillips, A., Taleski, D., Koplinski, C., Getschman, A., Moussouras, N., Richard, A., Peterson, F., Dwinell, M., Volkman, B., Payne, R., et al (2017). CCR7 sulfotyrosine enhances CCL21 binding. International Journal of Molecular Sciences, 18(9), 1-13. [More Information]

2016

  • Kiermaier, E., Moussion, C., Veldkamp, C., Gerardy-Schahn, R., de Vries, I., Williams, L., Chaffee, G., Phillips, A., Freiberger, F., Imre, R., Taleski, D., Payne, R., et al (2016). Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science, 351(6269), 186-190. [More Information]
  • Rogers, S., Fey, D., McCloy, R., Parker, B., Mitchell, N., Payne, R., Daly, R., James, D., Caldon, C., Watkins, D., et al (2016). PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells. Journal of Cell Science, 129(7), 1340-1354. [More Information]
  • Isahak, N., Gody, G., Malins, L., Mitchell, N., Payne, R., Perrier, S. (2016). Single addition of an allylamine monomer enables access to end-functionalized RAFT polymers for native chemical ligation. Chemical Communications, 52(88), 12952-12955. [More Information]

2015

  • Reeks, T., Jones, A., Brust, A., Sridharan, S., Corcilius, L., Wilkinson, B., Thaysen-Andersen, M., Payne, R., Kini, R., Daly, N., et al (2015). A defined alpha-helix in the bifunctional O-glycosylated natriuretic peptide TcNPa from the venom of Tropidechis carinatus. Angewandte Chemie - International Edition, 54(16), 4828-4831. [More Information]
  • Watson, G., Gunzburg, M., Ambaye, N., Lucas, W., Traore, D., Kulkarni, K., Cergol, K., Payne, R., Panjikar, S., Pero, S., et al (2015). Cyclic peptides incorporating phosphotyrosine mimetics as potent and specific inhibitors of the Grb7 breast cancer target. Journal of Medicinal Chemistry, 58(19), 7707-7718. [More Information]
  • Stone, M., Payne, R. (2015). Homogeneous sulfopeptides and sulfoproteins: Synthetic approaches and applications to characterize the effects of tyrosine sulfation on biochemical function. Accounts Of Chemical Research, 48(8), 2251-2261. [More Information]

2014

  • Maghzal, G., Cergol, K., Shengule, S., Suarna, C., Newington, D., Kettle, A., Payne, R., Stocker, R. (2014). Assessment of myeloperoxidase activity by the conversion of hydroethidine to 2-chloroethidium. Journal of Biological Chemistry, 289(9), 5580-5595. [More Information]
  • Malins, L., Cergol, K., Payne, R. (2014). Chemoselective sulfenylation and peptide ligation at tryptophan. Chemical Science, 5(1), 260-266. [More Information]
  • Huma, Z., Ludeman, J., Wilkinson, B., Payne, R., Stone, M. (2014). NMR characterization of cooperativity: fast ligand binding coupled to slow protein dimerization. Chemical Science, 5(7), 2783-2788. [More Information]

2013

  • Roche, M., Salimi, H., Duncan, R., Wilkinson, B., Chikere, K., Moore, M., Webb, N., Zappi, H., Sterjovski, J., Flynn, J., Payne, R., et al (2013). A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations. Retrovirology, 10(43), 1-20. [More Information]
  • Thompson, R., Chan, B., Radom, L., Jolliffe, K., Payne, R. (2013). Chemoselective peptide ligation-desulfurization at aspartate. Angewandte Chemie - International Edition, 52(37), 9723-9727. [More Information]
  • Collin, F., Thompson, R., Jolliffe, K., Payne, R., Maxwell, A. (2013). Fragments of the bacterial toxin microcin B17 as gyrase poisons. PloS One, 8(4), 1-9. [More Information]

2012

  • Tan, J., Canals, M., Ludeman, J., Wedderburn, J., Boston, C., Butler, S., Carrick, A., Parody, T., Taleski, D., Christopoulos, A., Payne, R., et al (2012). Design and receptor interactions of obligate dimeric mutant of chemokine monocyte chemoattractant protein-1 (MCP-1). Journal of Biological Chemistry, 287(18), 14692-14702. [More Information]
  • Hsieh, Y., Taleski, D., Wilkinson, B., Wijeyewickrema, L., Adams, T., Pike, R., Payne, R. (2012). Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin. Chemical Communications, 48(10), 1547-1549. [More Information]
  • Tran, A., West, N., Britton, W., Payne, R. (2012). Elucidation of Mycobacterium tuberculosis Type II Dehydroquinase Inhibitors using a Fragment Elaboration Strategy. ChemMedChem: chemistry enabling drug discovery, 7(6), 1031-1043. [More Information]

2011

  • Taleski, D., Butler, S., Stone, M., Payne, R. (2011). Divergent and Site-Selective Solid-Phase Synthesis of Sulfopeptides. Chemistry: An Asian Journal, 6(6), 1316-1320. [More Information]
  • West, N., Cergol, K., Xue, M., Randall, E., Britton, W., Payne, R. (2011). Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads. Chemical Communications, 47(18), 5166-5168. [More Information]
  • Thomas, G., Hsieh, Y., Chun, C., Cai, Z., Reimers, J., Payne, R. (2011). Peptide ligations accelerated by N-terminal aspartate and glutamate residues. Organic Letters, 13(18), 4770-4773. [More Information]

2010

  • Payne, R., Wong, C. (2010). Advances in chemical ligation strategies for the synthesis of glycopeptides and glycoproteins. Chemical Communications, 46(1), 21-43. [More Information]
  • Holt, D., Payne, R., Chow, W., Abell, C. (2010). Fluorosurfactants for microdroplets: Interfacial tension analysis. Journal of Colloid and Interface Science, 350(1), 205-211. [More Information]
  • Payne, R., Bulloch, E., Kerbarh, O., Abell, C. (2010). Inhibition of chorismate-utilising enzymes by 2-amino-4-carboxypyridine and 4-carboxypyridone and 5-carboxypyridone analogues. Organic and Biomolecular Chemistry, 8(15), 3534-3542. [More Information]

2009

  • Conroy, T., Jolliffe, K., Payne, R. (2009). Efficient use of the Dmab protecting group: Applications for the solid-phase synthesis of N-linked glycopeptides. Organic and Biomolecular Chemistry, 7(11), 2255-2258. [More Information]
  • Payne, R. (2009). Inhibition of Shikimate pathway enzymes as novel antibacterial leads (Biota Medal Lecture). 7th AFMC International Medicinal Chemistry Symposium, Cairns.
  • Payne, R. (2009). Ligation-based assembly of glycopeptides and glycoproteins. Seminar, School of Chemistry, Monash University, N/A: N/A.

2008

  • Bennett, C., Payne, R., Koeller, K., Wong, C. (2008). Biologically relevant glycopeptides: Synthesis and applications. In Bertram O Fraser-Reid, Kuniaki Tatsuta, Joachim Thiem (Eds.), Glycoscience. Chemistry and Chemical Biology, (pp. 1795-1857). New York, USA: Springer.
  • Payne, R., Ficht, S., Greenberg, W., Wong, C. (2008). Cysteine-free peptide and glycopeptide ligation by direct aminolysis. Angewandte Chemie - International Edition, 47(23), 4411-4415. [More Information]
  • Ficht, S., Payne, R., Guy, R., Wong, C. (2008). Solid-phase synthesis of peptide and glycopeptide thioesters through side-chain-anchoring strategies. Chemistry - A European Journal, 14(12), 3620-3629. [More Information]

2007

  • Payne, R., Riboldi-Tunnicliffe, A., Kerbarh, O., Abell, A., Lapthorn, A., Abell, C. (2007). Design, Synthesis, and Structural Studies on Potent Biaryl Inhibitors of Type II Dehydroquinases. ChemMedChem: chemistry enabling drug discovery, 2(7), 1010-1013. [More Information]
  • Payne, R., Ficht, S., Tang, S., Brik, A., Yang, Y., Case, D., Wong, C. (2007). Extended Sugar-Assisted Glycopeptide Ligations: Development, Scope, and Applications. Journal of the American Chemical Society, 129(44), 13527-13536. [More Information]
  • Abell, A., Jones, M., Neffe, A., Aitken, S., Cain, T., Payne, R., McNabb, S., Coxon, J., Stuart, B., Pearson, D., et al (2007). Investigation into the P3 Binding Domain of m-Calpain Using Photoswitchable Diazo- and Triazene-dipeptide Aldehydes: New Anticataract Agents. Journal of Medicinal Chemistry, 50(12), 2916-2920. [More Information]

2005

  • Payne, R., Bulloch, E., Abell, A., Abell, C. (2005). Design and synthesis of aromatic inhibitors of anthranilate synthase. Organic and Biomolecular Chemistry, 3(20), 3629-3635. [More Information]
  • Payne, R., Kerbarh, O., Miguel, R., Abell, A., Abell, C. (2005). Inhibition studies on salicylate synthase. Organic and Biomolecular Chemistry, 3(10), 1825-1827. [More Information]
  • Payne, R., Edmonds, M. (2005). Isolation of Shikimic Acid from Star Aniseed. Journal of Chemical Education, 82(4), 599-600.

2004

  • Payne, R., Brown, K., Coxon, J., Morton, J., Lee, H., Abell, A. (2004). Peptidic aldehydes based on alpha- and beta-amino acids: Synthesis, inhibition of m-calpain, and anti-cataract properties. Australian Journal of Chemistry, 57(9), 877-884. [More Information]
  • Payne, R., Daines, A., Clark, B., Abell, A. (2004). Synthesis and protein conjugation studies of vitamin K analogues. Bioorganic and Medicinal Chemistry, 12(22), 5785-5791. [More Information]

2003

  • de Zwart, F., Slow, S., Payne, R., Lever, M., George, P., Gerrard, J., Chambers, S. (2003). Glycine betaine and glycine betaine analogues in common foods. Food Chemistry, 83(2), 197-204. [More Information]
  • Daines, A., Payne, R., Humphries, M., Abell, A. (2003). The Synthesis of Naturally Occurring Vitamin K and Vitamin K Analogues. Current Organic Chemistry, 7(16), 1625-1634. [More Information]

2002

  • Payne, R., Abell, A. (2002). Protein binding studies of vitamin K analogues for use in an immunological assay. Chemistry in New Zealand, 66(1), 16-26.

Selected Grants

2025

  • Reprogrammed cyclic peptides as next-generation targeted protein degraders, Payne R, Mackay J, Zhong Y, Australian Research Council (ARC)/Linkage Projects (LP)

2024

  • Exploring and Driving Cooperative International Strategies in Sustainable Chiral Pool Natural Product Synthesis, Payne R, UK Research and Innovation/Biotechnology and Biological Sciences Research Council
  • A new diagnostic test for AD based on a neurotoxic Abeta Dimer, Payne R, Schey K, National Institutes of Health (USA)/Research Support

In the media

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