Professor Trevor Hambley

FAA; BSc UWA; PhD Adelaide
Professor of Chemistry
Dean of Science

F11 - Chemistry Building
The University of Sydney

Telephone 61 2 9351 4123
Fax 61 2 9351 3329

Website Research Group
Faculty of Science Contact Details

Biographical details

Trevor Hambley is Professor of Chemistry at the University of Sydney's School of Chemistry. He has studied and worked at the Universities of Western Australia (BSc Hons(I)) and Adelaide (PhD), ANU, The University of Sydney, Emory University and Birkbeck College, University of London.

His research interests are in the area of medicinal inorganic chemistry with an emphasis on platinum anticancer drugs, hypoxia selective cobalt complexes, and metal based anti-inflammatory compounds. He has published 3 books, 13 reviews, and more than 400 refereed journal papers, including four recent reviews of the relationship between the structure of Pt anticancer agents and their toxicity and anticancer activity and on the modelling of Pt/DNA interactions.

Professor Hambley was the recipient of the Edgeworth David Medal for contributions to Science by an Australian under the age of 35 and has received the “Supervisor of the Year” award at the University of Sydney in 1997 and an Excellence in Teaching Award for Postgraduate Supervision in 1998.

Research interests

  • Medicinal inorganic chemistry, in particular, Pt anticancer drugs
  • Investigating the relationship between the reduction potentials of Pt(IV) complexes and their biological activity
  • Investigating methods for controlling the physical and biological properties of platinum(IV) complexes
  • Development of synchrotron radiation based methods for the in situ determination of oxidation states of platinum in biological environments and for reliably determining platinum distributions in these environments
  • Investigation of cobalt complexes as delivery agents for matrix metalloproteinase inhibitors and other anticancer agents
  • Employing XANES technique to determine oxidation states of the cobalt complexes in solution
  • Investigating and optimizing anticancer drug uptake in solid tumours and tumour models.
  • Please see our home page for detailed coverage of our research activities.

Current projects

Please see our home page for detailed coverage of our research activities at http://sydney.edu.au/science/chemistry/~hamble_t/

Awards and honours

  • Edgeworth David Medal for contributions to Science by an Australian under the age of 35
  • “Supervisor of the Year” award at the University of Sydney in 1997
  • Excellence in Teaching Award for Postgraduate Supervision in 1998.

Selected grants

2014

  • Perpetual Account for Australian Synchrotron Access Programme T W Hambley; Hambley T; Australian Synchrotron Company Limited/Funding Application for Interstate User Groups.

2011

  • Innovative Synchrotron Science - Access Program to the Australian National Beamline Facility and Cutting-Edge Beamlines at International Synchrotrons; Lay P, Waite T, Gerson, A, Harris H, Collins R, Dillon C, Brugger J, Garrett R, Wilce M, De Marco R, Tardio J, Spiccia L, Zhang L, Aguilar M, Hambley T, Harmer-Bassell S, Burton E, Bush R, Johnston S, Trevitt A, Kepert C, Chantler C, Shimomura O, Bond C, Gray E, Noller B, Gentle I, Sullivan L, Creagh D, Low I; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Development of prodrug strategies for achieving increased penetration and selective activation in solid tumours; Hambley T, Metzler-Nolte N; Australian Research Council (ARC)/Discovery Projects (DP).

2010

  • Radiolabelled MMP Binding Agents for the Identification, Quantification, and Targeting of MMPs in CNS Disorders and Tumours; Hambley T, Kassiou M; Australian Research Council (ARC)/Discovery Projects (DP).

2007

  • Rational Optimisation of the Uptake of metal-Based Anti-Cancer Agents by Tumours; Hambley T; Australian Research Council (ARC)/Discovery Projects (DP).

Selected publications

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Books

  • Comba, P., Hambley, T., Martin, B. (2009). Molecular Modeling of Inorganic Compounds: Third, Completely Revised and Enlarged Edition. Federal Republic of Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Hambley, T., Comba, P. (2001). Molecular Modeling of Inorganic Compounds. Germany: Wiley - V C H Verlag GmbH & Co. KGaA.

Book Chapters

  • Norman, J., Hambley, T. (2011). Targeting strategies for metal-based therapeutics. In Professor Enzo Alessio (Eds.), Bioinorganic Medicinal Chemistry, (pp. 49-78). Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Zhang, J., Whan, R., Hambley, T. (2009). Platinum anticancer drugs, chemical biology of. In Natanya Civjan (Eds.), Wiley Encyclopaedia of Chemical Biology, (pp. 721-730). Hoboken, New Jersey, USA: John Wiley & Sons.
  • Guenther, K., Hambley, T., Kassiou, M. (2008). Radiolabelled probes for imaging multidrug resistance using single photon emission tomography (SPECT) and positron emission tomography (PET). In Nicola Antonio Colabufo (Eds.), Multidrug Resistance: Biological and Pharmaceutical Advances in Antitumour Treatment, (pp. 291-320). India: Research Signpost.
  • Dillon, C., Hambley, T., Kennedy, B., Lay, P., Weder, J., Zhou, Q. (2004). Copper And Zinc Complexes As Antiinflammatory Drugs. In Astrid Sigel & Helmut Sigel (Eds.), Metal Ions in Biological Systems : Volume 41 : Metal Ions and their Complexes in Medication, (pp. 253-277). New York: Marcel Dekker.
  • Rendina, L., Hambley, T. (2004). Platinum. In D. E. Fenton (Eds.), Comprehensive Coordination Chemistry II : From biology to nanotechnology. Volume 6: Transition Metal groups 9-12, (pp. 673-745). Amsterdam: Elsevier.
  • Hall, M., Dolman, R., Hambley, T. (2004). Platinum(Iv) Anticancer Complexes. In Astrid Sigel & Helmut Sigel (Eds.), Metal Ions in Biological Systems: Volume 42. Metal Complexes in Tumor Diagnosis and as Anticancer Agents, (pp. 297-322). New York: Marcel Dekker.

Journals

  • Renfrew, A., Bryce, N., Hambley, T. (2013). Delivery and release of curcumin by a hypoxia-activated cobalt chaperone: a XANES and FLIM study. Chemical Science, 4(9), 3731-3739. [More Information]
  • Zhang, J., Bonnitcha, P., Wexselblatt, E., Klein, A., Najajreh, Y., Gibson, D., Hambley, T. (2013). Facile preparation of mono-, di- and mixed-carboxylato platinum(IV) complexes for versatile anticancer prodrug design. Chemistry: A European Journal, 19(5), 1672-1676. [More Information]
  • Chen, C., Zhang, J., Aitken, J., Hambley, T. (2013). Influence of equatorial and axial carboxylato ligands on the kinetic inertness of platinum(IV) complexes in the presence of ascorbate and cysteine and within DLD-1 cancer cells. Journal of Medicinal Chemistry, 56(21), 8757-8764. [More Information]
  • Roberts, M., Pham, T., Doan, J., Fraser, B., Hambley, T., Greguric, I. (2013). Radiosynthesis of [18F]-ethynyl-4-fluorobenzene for click conjugation. Journal of Labelled Compounds and Radiopharmaceuticals, 56(S1), P091-P091.
  • Bryce, N., Pham, T., Fong, N., Jain, N., Pan, E., Whan, R., Hambley, T., Hawkett, B. (2013). The composition and end-group functionality of sterically stabilized nanoparticles enhances the effectiveness of co-administered cytotoxins. Biomaterials Science, 1(12), 1260-1272. [More Information]
  • Bonnitcha, P., Kim, B., Hocking, R., Clegg, J., Turner, P., Neville, S., Hambley, T. (2012). Cobalt complexes with tripodal ligands: Implications for the design of drug chaperones. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 41(37), 11293-11304. [More Information]
  • Yamamoto, N., Renfrew, A., Kim, B., Bryce, N., Hambley, T. (2012). Dual Targeting of Hypoxic and Acidic Tumor Environments with a Cobalt(III) Chaperone Complex. Journal of Medicinal Chemistry, 55(24), 11013-11021. [More Information]
  • Yamamoto, N., Bryce, N., Metzler-Nolte, N., Hambley, T. (2012). Effects of enzymatic activation on the distribution of fluorescently tagged MMP-2 cleavable peptides in cancer cells and spheroids. Bioconjugate chemistry, 23(6), 1110-1118. [More Information]
  • Zhang, J., Bryce, N., Lanzirotti, A., Chen, C., Paterson, D., De Jonge, M., Howard, D., Hambley, T. (2012). Getting to the core of platinum drug bio-distributions: the penetration of anti-cancer platinum complexes into spheroid tumour models. Metallomics, 4(11), 1209-1217. [More Information]
  • Zhang, J., Wexselblatt, E., Hambley, T., Gibson, D. (2012). Pt(IV) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate. Chemical Communications, 48(6), 847-849. [More Information]
  • Hall, M., Daly, H., Zhang, J., Zhang, M., Alderden, R., Pursche, D., Foran, G., Hambley, T. (2012). Quantitative measurement of the reduction of platinum(IV) complexes using X-ray absorption near-edge spectroscopy (XANES). Metallomics, 4(6), 568-575. [More Information]
  • Failes, T., Battle, A., Chen, C., Cullinane, C., Woods, R., Elliott, R., Deacon, G., Hambley, T. (2012). Structural and anticancer properties of hydrogen bonded diphenyl phosphate adducts of Pt(IV) complexes: The importance of pKa matching. Journal of Inorganic Biochemistry, 115, 220-225. [More Information]
  • Guo, S., Mason, D., Turland, S., Lawrenz, E., Kelly, L., Fallon, G., Gatehouse, B., Bond, A., Deacon, G., Battle, A., Hambley, T., et al (2012). Systematic differences in electrochemical reduction of the structurally characterized anti-cancer platinum(IV) complexes [Pt{((p-HC6F4)NCH2)2}-(pyridine)2Cl2], [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)2], and [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)Cl]. Journal of Inorganic Biochemistry, 115(2012), 226-239. [More Information]
  • Zhang, J., Bryce, N., Siegele, R., Carter, E., Paterson, D., De Jonge, M., Howard, D., Ryan, C., Hambley, T. (2012). The use of spectroscopic imaging and mapping techniques in the characterisation and study of DLD-1 cell spheroid tumour models. Integrative Biology, 4(9), 1072-1080. [More Information]
  • Wolf, S., Huynh, T., Bryce, N., Hambley, T., Wakelin, L., Stewart, B., Catchpoole, D. (2011). Intracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cells. BMC Cell Biology, 12(36), 1-11. [More Information]
  • Yadav, P., Beveridge, R., Blay, J., Boyd, A., Chojnacka, M., Decken, A., Deshpande, A., Gardiner, M., Hambley, T., Hughes, M., New, E., et al (2011). Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies. MedChemComm (Medicinal Chemistry Communications), 2(4), 274-277. [More Information]
  • Daly, H., Hall, M., Failes, T., Zhang, M., Foran, G., Hambley, T. (2011). Stabilization of Triam(m)inechloridoplatinum Complexes by Oxidation to Pt(IV). Australian Journal of Chemistry: an international journal for chemical science, 64(3), 273-278. [More Information]
  • Cubo, L., Hambley, T., Sanz Miguel, P., Carnero, A., Navarro-Ranninger, C., Quiroga, A. (2011). The preparation and characterization of trans-platinum(IV) complexes with unusually high cytotoxicity. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 40(2), 344-347. [More Information]
  • Kim, B., Hambley, T., Bryce, N. (2011). Visualising the hypoxia selectivity of cobalt(III) prodrugs. Chemical Science, 2(11), 2135-2142. [More Information]
  • Ma, Y., Bryce, N., Whan, R., Xiao, L., Li, K., Ruys, A., Hambley, T., Boughton, P. (2010). Growth of DLD-1 Colon Cancer Cells on Variotis™ Scaffolds of Controlled Porosity: A Preliminary Study. Journal of Biomimetics, Biomaterials, and Tissue Engineering, 8, 79-89. [More Information]
  • Bonin, A., Yanez, J., Fukuda, C., Teng, X., Dillon, C., Hambley, T., Lay, P., Davies, N. (2010). Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. Cancer Chemotherapy and Pharmacology, 66(4), 755-764. [More Information]
  • Battle, A., Bond, A., Chow, A., Daniels, D., Deacon, G., Hambley, T., Junk, P., Mason, D., Wang, J. (2010). Syntheses and structures of N-polyfluorophenyl- and N,N'-bis(polyfluorophenyl)ethane-1,2-diaminato(1- or 2-)platinum(II) complexes. Journal of Fluorine Chemistry, 131(11), 1229-1236.
  • Bryce, N., Zhang, J., Whan, R., Yamamoto, N., Hambley, T. (2009). Accumulation of an anthraquinone and its platinum complexes in cancer cell spheroids: The effect of charge on drug distribution in solid tumour models. Chemical Communications, 2009 (19), 2673-2675.
  • Whan, R., Messerle, B., Hambley, T. (2009). Binding of [Pt(1C3)(dien)]2+ to the duplex DNA oligonucleotide 5'-d(TGGCCA)-3': The effect of an appended positive charge on the orientation and location of anthraquinone intercalation. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2009 (6), 932-939.
  • Er, H., Hambley, T. (2009). Enantioselectivity and stereoselectivity in the reactions of the enantiomers of the platinum complex [PtCl(2)(ahaz)] (ahaz = 3(R)- or 3(S)-aminohexahydroazepine) with DNA. Journal of Inorganic Biochemistry, 103(2), 168-173. [More Information]
  • New, E., Roche, C., Madawala, R., Zhang, J., Hambley, T. (2009). Fluorescent analogues of quinoline reveal amine ligand loss from cis and trans platinum(II) complexes in cancer cells. Journal of Inorganic Biochemistry, 103(8), 1120-1125. [More Information]
  • Diakos, C., Messerie, B., Murdoch, P., Parkinson, J., Sadler, P., Fenton, R., Hambley, T. (2009). Identification by NMR spectroscopy of the two stereoisomers of the platinum complex [PtCl2(S-ahaz)] (S-ahaz = 3(S)-aminohexahydroazepine) bound to a DNA 14-mer oligonucleotide. NMR evidence of structural alteration of a platinated A x T-rich 14-mer DNA duplex. Inorganic Chemistry, 48(7), 3047-56. [More Information]
  • Diakos, C., Messerle, B., Murdoch, P., Parkinson, J., Sadler, P., Fenton, R., Hambley, T. (2009). Identification by NMR spectroscopy of the two steroisomers of the platinum complex [PtCl2(S-ahaz)] (S-ahaz = 3(S)-aminohexahydroazepine) bound to a DNA 14-mer oligonucleotide. NMR evidence of structural alteration of a platinated A.T-rich 14-mer DNA duplex. Inorganic Chemistry, 48(7), 3047-3056.
  • New, E., Duan, R., Zhang, J., Hambley, T. (2009). Investigations using fluorescent ligands to monitor platinum(IV) reduction and platinum(II) reactions in cancer cells. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2009 (16), 3092-3101.
  • Clarke, A., Yamamoto, N., Jensen, P., Hambley, T. (2009). Iron(III) complexes of fluorescent hydroxamate ligands: preparation, properties, and cellular processing. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2009 (48), 10787-10798.
  • Hambley, T. (2009). Is anticancer drug development heading in the right direction? Cancer Research, 69(4), 1259-1262.
  • Klein, A., Hambley, T. (2009). Platinum drug distribution in cancer cells and tumors. Chemical Reviews, 109(10), 4911-4920.
  • Diakos, C., Zhang, M., Beale, P., Fenton, R., Hambley, T. (2009). Synthesis, characterisation and in vitro cytotoxicity studies of a series of chiral platinum(II) complexes based on the 2-aminomethylpyrrolidine ligand: X-ray crystal structure of [PtC12(R-dimepyrr)] (R-dimepyrr = N-dimethyl-2(R)-aminomethylpyrrolidine). European Journal of Medicinal Chemistry, 44(7), 2807-2814. [More Information]
  • Hambley, T. (2009). Targeted cancer therapeutics response. Cancer Research, 69(4), 1267-1267.
  • Davies, M., Hall, M., Berners-Price, S., Hambley, T. (2008). [(1)H, (15)N] Heteronuclear Single Quantum Coherence NMR Study of the Mechanism of Aquation of Platinum(IV) Ammine Complexes. Inorganic Chemistry, 47(17), 7673-7680.
  • Yamamoto, N., Danos, S., Bonnitcha, P., Failes, T., New, E., Hambley, T. (2008). Cellular uptake and distribution of cobalt complexes of fluorescent ligands. Journal of Biological Inorganic Chemistry, 13(6), 861-871. [More Information]
  • Hambley, T. (2008). Physiological Targeting to Improve Anticancer Drug Selectivity. Australian Journal of Chemistry: an international journal for chemical science, 61(9), 647-653.
  • Hall, M., Mellor, H., Callaghan, R., Hambley, T. (2007). Basis for design and development of platinum(IV) anticancer complexes. Journal of Medicinal Chemistry, 50(15), 3403-3411.
  • Hall, M., Failes, T., Yamamoto, N., Hambley, T. (2007). Bioreductive activation and drug chaperoning in cobalt pharmaceuticals. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, (36), 3983-3990.
  • Hocking, R., Hambley, T. (2007). Database analysis of transition metal carbonyl bond lengths: Insight into the periodicity of pi back-bonding, sigma donation, and the factors affecting the electronic structure of the TM-C=O moiety. Organometallics, 26(11), 2815-2823.
  • Hambley, T. (2007). Developing new metal-based therapeutics: Challenges and opportunities. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2007 (43), 4929-4937.
  • Hocking, R., Deeth, R., Hambley, T. (2007). DFT study of the systematic variations in metal-ligand bond lengths of coordination complexes: The crucial role of the condensed phase. Inorganic Chemistry, 46(20), 8238-8244.
  • Alderden, R., Mellor, H., Modok, S., Hall, M., Sutton, S., Newville, M., Callaghan, R., Hambley, T. (2007). Elemental tomography of cancer-cell spheroids reveals incomplete uptake of both platinum(II) and platinum(IV) complexes. Journal of the American Chemical Society, 129(44), 13400-13401.
  • Hambley, T. (2007). Metal-based therapeutics. Science, 318(5855), 1392-1393.
  • Failes, T., Cullinane, C., Diakos, C., Yamamoto, N., Lyons, J., Hambley, T. (2007). Studies of a Cobalt(III) complex of the MMP inhibitor marimastat: A potential hypoxia-activated prodrug. Chemistry: A European Journal, 13(10), 2974-2982. [More Information]
  • Failes, T., Hambley, T. (2007). Towards bioreductively activated prodrugs: Fe(III) complexes of hydroxamic acids and the MMP inhibitor marimastat. Journal of Inorganic Biochemistry, 101, 396-403. [More Information]
  • Modok, S., Scott, R., Alderden, R., Hall, M., Mellor, H., Bohic, S., Roose, T., Hambley, T., Callaghan, R. (2007). Transport kinetics of four- and six-coordinate platinum compounds in the multicell layer tumour model. British Journal of Cancer, 97(2), 194-200.
  • Hall, M., Underwood, C., Failes, T., Foran, G., Hambley, T. (2007). Using XANES to monitor the oxidation state of cobalt complexes. Australian Journal of Chemistry: an international journal for chemical science, 60(3), 180-183.
  • Alderden, R., Mellor, H., Modok, S., Hambley, T., Callaghan, R. (2006). Cytotoxic efficacy of an anthraquinone linked platinum anticancer drug. Biochemical Pharmacology, 71(8), 1136-1145. [More Information]
  • Diakos, C., Fenton, R., Hambley, T. (2006). DNA-binding and molecular mechanics modelling studies of the bulky chiral platinum(II) complex [PtCl2(mepyrr)] (mepyrr = N-methyl-2-aminomethylpyrrolidine). Journal of Inorganic Biochemistry, 100(12), 1965-1973. [More Information]
  • Costa, L., Hambley, T., Rocha, W., De Almeida, W., Dos Santos, H. (2006). Kinetics and structural aspects of the cisplatin interactions with guanine: A quantum mechanical description. International Journal of Quantum Chemistry, 106(9), 2129-2144. [More Information]
  • Failes, T., Hambley, T. (2006). Models of hypoxia activated prodrugs: Co(III) complexes of hydroxamic acids. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2006 (15), 1895-1901.
  • Battle, A., Choi, R., Hibbs, D., Hambley, T. (2006). Platinum(IV) analogues of AMD473 (cis-[PtCl2(NH3)(2-picoline)]): preparative, structural, and electrochemical studies. Inorganic Chemistry, 45(16), 6317-6322. [More Information]
  • Alderden, R., Hall, M., Hambley, T. (2006). The discovery and development of cisplatin. Journal of Chemical Education, 83(5), 728-734.
  • Hall, M., Alderden, R., Zhang, M., Beale, P., Cai, Z., Lai, B., Stampfl, A., Hambley, T. (2006). The fate of platinum(II) and platinum(IV) anti-cancer agents in cancer cells and tumours. Journal of Structural Biology, 155(1), 38-44. [More Information]
  • Bonnitcha, P., Hall, M., Underwood, C., Foran, G., Zhang, M., Beale, P., Hambley, T. (2006). XANES investigation of the Co oxidation state in solution and in cancer cells treated with Co(III) complexes. Journal of Inorganic Biochemistry, 100(5-6), 963-971. [More Information]
  • Malina, J., Voitiskova, M., Brabec, V., Diakos, C., Hambley, T. (2005). DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins. Biochemical and Biophysical Research Communications, 332(4), 1034-1041. [More Information]
  • Ramadan, S., Bonin, A., Kennedy, B., Hambley, T., Lay, P. (2005). Nuclear magnetic resonance analysis of indomethacin-induced gastric ulcers. Chemical Research in Toxicology, 18(2), 123-128.
  • Hocking, R., Hambley, T. (2005). Structural measures of element-oxygen bond covalency from the changes to the delocalisation of the carboxylate ligand. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2005 (5), 969-978.
  • Mellor, H., Hall, M., Hambley, T., Snelling, S., Modok, S., Jaffar, M., Callaghan, R. (2005). The influence of tumour microenvironmental factors on the efficacy of cisplatin and novel platinum(IV) complexes. Biochemical Pharmacology, 70(8), 1137-1146. [More Information]
  • Hall, M., Martin, C., Ferguson, D., Phillips, R., Hambley, T., Callaghan, R. (2004). Comparative Efficacy Of Novel Platinum(IV) Compounds With Established Chemotherapeutic Drugs In Solid Tumour Models. Biochemical Pharmacology, 67(1), 17-30. [More Information]
  • Ramadan, S., Hambley, T., Kennedy, B., Lay, P. (2004). Nmr Spectroscopic Characterization Of Copper(Ii) And Zinc(Ii) Complexes Of Indomethacin. Inorganic Chemistry, 43(9), 2943-2946.
  • Allan, R., Greenwood, J., Hambley, T., Hanrahan, J., Hibbs, D., Itani, S., Tran, H., Turner, P. (2004). Studies On Pyridazine Azide Cyclisation Reactions. Organic and Biomolecular Chemistry, 2(12), 1782-8-1788.
  • Hall, M., Amjadi, S., Zhang, M., Beale, P., Hambley, T. (2004). The mechanism of action of platinum(IV) complexes in ovarian cancer cell lines. Journal of Inorganic Biochemistry, 98, 1614-1624. [More Information]
  • Levina, A., Codd, R., Foran, G., Hambley, T., Maschmeyer, T., Masters, A., Lay, P. (2004). X-Ray Absorption Spectroscopic Studies Of Chromium(V/Iv/Iii)2-Ethyl-2-Hydroxybutanoato(2-/1-) Complexes. Inorganic Chemistry, 43(3), 1046-1055.
  • Failes, T., Diakos, C., Underwood, C., Hambley, T., Cullinane, C., Lyons, J. (2003). Can metal complexes serve as hypoxia activated prodrugs? Investigations of a Co(III) complex of the MMP inhibitor marimastat. Journal of Inorganic Biochemistry, 96(1), 128.
  • Field, L., Messerle, B., Rehr, M., Soler, L., Hambley, T. (2003). Cationic iridium(I) complexes as catalysts for the alcoholysis of silanes. Organometallics, 22(12), 2387-2395.
  • Hall, M., Hambley, T., Beale, P., Zhang, M., Dillon, C., Foran, G., Stampfl, A., Lai, B. (2003). Does platinum(IV) survive in tumour cells? Journal of Inorganic Biochemistry, 96(1), 141.
  • Waller, M., Hibbs, D., Overgaard, J., Hanrahan, J., Hambley, T. (2003). Flavone. Acta Crystallographica. Section E: Structure Reports Online, 59(6), o767-o768.
  • Dillon, C., Hambley, T., Kennedy, B., Lay, P., Zhou, Q., Davies, N., Biffen, R., Regtop, H. (2003). Gastrointestinal Toxicity, Antiinflammatory Activity, and Superoxide Dismutase Activity of Copper and Zinc Complexes of the Antiinflammatory Drug Indomethacin. Chemical Research in Toxicology, 16(1), 28-37.
  • Alderden, R., Hall, M., Amjadi, S., Hambley, T., Beale, P., Zhang, M., Lai, M., Stampfl, A. (2003). Increasing the cellular accumulation of platinum(IV) complexes. Journal of Inorganic Biochemistry, 96(1), 89.
  • Failes, T., Hambley, T. (2003). Insights into Pt(II)-hydroxamate bonding through the crystal structures of DMSO complexes. Australian Journal of Chemistry: an international journal for chemical science, 56(1), 45-48.
  • Bulluss, G., Waller, M., Hambley, T. (2003). Investigation of rotamers about the Pt-N7 bonds in bulky [Pt(d(GpG))(diamine)] complexes. Journal of Inorganic Biochemistry, 96(1), 108.
  • Munk, V., Diakos, C., Ellis, L., Fenton, R., Hambley, T., Messerle, B. (2003). Investigations into the interactions between DNA and conformationally constrained pyridylamineplatinum(II) analogues of AMD473. Inorganic Chemistry, 42(11), 3582-3590.
  • Bernhardt, P., Hambley, T., Lawrance, G., Maeder, M., Wilkes, E. (2003). Isomers of 1,4,8,11-tetraazacyclotetradecane-6,13-dicarboxylate characterized as cobalt(III) complexes. Australian Journal of Chemistry: an international journal for chemical science, 56(7), 679-684.
  • Bulluss, G., Waller, M., Hambley, T. (2003). Mechanism of action of platinum complex binding to DNA. Journal of Inorganic Biochemistry, 96(1), 109.
  • Brown, K., Geue, R., Hambley, T., Hockless, D., Rae, A., Sargeson, A. (2003). Specificity in template syntheses of hexaaza-macrobicyclic cages: [Pt(Me5-tricosatrieneN6)]4+ and [Pt(Me5-tricosaneN6)]4+. Organic and Biomolecular Chemistry, 1, 1598-1608.
  • Hocking, R., Hambley, T. (2003). Structural insights into transition-metal carbonyl bonding. Chemical Communications, 2003 (13), 1516-1517.
  • Hocking, R., Hambley, T. (2003). Structural measure of metal-ligand covalency from the bonding in carboxylate ligands. Inorganic Chemistry, 42(9), 2833-2835.
  • Hall, M., Dillon, C., Zhang, M., Beale, P., Cai, Z., Lai, B., Stampfl, A., Hambley, T. (2003). The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells. Journal of Biological Inorganic Chemistry, 8(7), 726-732. [More Information]
  • Hibbs, D., Overgaard, J., Hambley, T., Gatti, C. (2003). The electron density in flavones I. Baicalein. New Journal of Chemistry, 27(9), 1392-1398.
  • Failes, T., Hall, M., Hambley, T. (2003). The first examples of platinum amine hydroxamate complexes: structures and biological activity. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2003 (8), 1596-1600.
  • Underwood, C., Min, D., Lyons, J., Hambley, T. (2003). The interaction of metal ions and Marimastat with matrix metalloproteinase 9. Journal of Inorganic Biochemistry, 95(2-3), 165-170.
  • Ellis, L., Perkins, D., Turner, P., Hambley, T. (2003). The preparation and charcterisation of cyclam/anthraquinone macrocyle/intercalator complexes and their interactions with DNA. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2003 (13), 2728-2736.
  • Giannikopoulos, G., Teo, C., Hall, M., Fenton, R., Hambley, T. (2003). The synthesis and in vitro cytotoxicity of two trans-platinum complexes of heterocyclic amines. Australian Journal of Chemistry: an international journal for chemical science, 56(7), 685-689.
  • Zhou, Q., Hambley, T., Kennedy, B., Lay, P. (2003). XAFS studies of anti-inflammatory dinuclear and mononuclear Zn(II) complexes of indomethacin. Inorganic Chemistry, 42(25), 8557-8566.
  • Hall, M., Foran, G., Zhang, M., Beale, P., Hambley, T. (2003). XANES determination of the platinum oxidation state distribution in cancer cells treated with platinum(IV) anticancer agents. Journal of the American Chemical Society, 125(25), 7524-7525.
  • Hotze, A., Chen, Y., Hambley, T., Parsons, S., Kratochwil, N., Parkinson, J., Munk, V., Sadler, P. (2002). Cis-[PtCl2(NH3){2-(2-hydroxyethyl)pyridine}] - an Analogue of the Anticancer Drug AMD473: Unusual Hydrolysis Rates and pKa Values for the Diaqua Adduct. European Journal of Inorganic Chemistry, 2002 (5), 1035-1039.
  • Weder, J., Dillon, C., Hambley, T., Kennedy, B., Lay, P., Biffin, J., Regtop, H., Davies, N. (2002). Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized. Coordination Chemistry Reviews, 232(1-2), 95-126.
  • Battle, A., Deacon, G., Dolman, R., Hambley, T. (2002). Electrochemistry, Protein Binding and Crystal Structures of Platinum(II) and Platinum(IV) Carboxylato Complexes. Australian Journal of Chemistry: an international journal for chemical science, 55(11), 699-704.
  • Davies, M., Wong, P., Battle, A., Haddad, G., McKeage, M., Hambley, T. (2002). Examination of the effects of oxidation and ring closure on the cytotoxicities of the platinum complexes of N-(2-hydroxyethyl)ethane-1,2-diamine and ethane-1,2-diamine-N,N9-diacetic acid. Journal of Inorganic Biochemistry, 91(1), 205-211.
  • Hambley, T., Hibbs, D., Turner, P., Howard, S., Hursthouse, M. (2002). Insights into bonding and hydrogen bond directionality in thioacetamide from the experimental charge distribution. Journal of the Chemical Society Perkin Transactions 2, 2(2002), 235-239.
  • Munk, V., Cham, S., Fenton, R., Hocking, R., Hambley, T. (2002). Insights into the van der Waals Radius of Low-Spin Ni(II) from Molecular Mechanics Studies and the Crystal Structures of [Ni(cis-cyclohexane-1,3-diamine)2]Cl2, [Ni{(R)-5,5,7-trimethyl-1,4-diazacycloheptane}2]Cl2.H2O and [Ni(5,7-dimethyl-1,4-diazacyclohept. Australian Journal of Chemistry: an international journal for chemical science, 55(8), 523-529.
  • Field, L., Messerle, B., Soler, L., Hambley, T., Turner, P. (2002). Iron(II) complexes containing poly(1-pyrazolyl)methane ligands. Journal of Organometallic Chemistry, 655(1-2), 146-157.
  • Greguric, A., Greguric, I., Hambley, T., Aldrich-Wright, J., Collins, J. (2002). Minor groove intercalation of Delta-[Ru(Me2phen)2dppz]2+ to the hexanucleotide d(GTCGAC)2. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 10, 849-855.
  • Hall, M., Hambley, T. (2002). Platinum(IV) antitumour compounds: their bioinorganic chemistry. Coordination Chemistry Reviews, 232(1-2), 49-67.
  • Cullinane, C., Deacon, G., Drago, P., Hambley, T., Nelson, K., Webster, L. (2002). Preparation and cell growth inhibitory activity of [PtR2L2] (R=polyfluorophenyl, L2 = diene, cyclohexane-1,2-diamine (chxn) or cis-(dimethyl sulfoxide)2) and the X-ray crystal structure of [Pt(C6F5)2(cis-chxn)]. Journal of Inorganic Biochemistry, , 293-301.
  • Hocking, R., Hambley, T. (2002). Statistical and Molecular Mechanics Analysis of the Effects of Changing Donor Type on Bond Length in the Two Series [CoIIINnO6-n] and [NiIINnO6-n] (n = 0-6): A New Route to Bond-Stretch Parameters. Inorganic Chemistry, 41(10), 2660-2666.
  • Munk, V., Diakos, C., Messerle, B., Fenton, R., Hambley, T. (2002). Stereospecificity and Enantioselectivity in the Binding of the Platinum(II) Complex [PtCl2(tmdz)] (tmdz=5,5,7-Trimethyl-1,4-diazacycloheptane) to Dinucleotides and Oligonucleotides. Chemistry: A European Journal, 8(23), 5486-5493.
  • Hall, M., Failes, T., Hibbs, D., Hambley, T. (2002). Structural Investigations of Palladium(II) and Platinum(II) Complexes of Salicylhydroxamic Acid. Inorganic Chemistry, 41(5), 1223-1228.
  • Dolman, R., Deacon, G., Hambley, T. (2002). Studies of the binding of a series of platinum(IV) complexes to plasma proteins. Journal of Inorganic Biochemistry, 88(3-4), 260-267.
  • Wei, G., Hambley, T., Lawrance, G., Maeder, M. (2002). Synthesis and Complexation of a Chiral Sexidentate Pendant-Arm Macropolycyclic Polyamino Acid. Australian Journal of Chemistry: an international journal for chemical science, 55(10), 667-673.
  • Battle, A., Platts, J., Hambley, T., Deacon, G. (2002). Synthesis, spectroscopy, and theoretical studies of platinum(II) phosphate complexes. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, , 1898-1902.
  • Aldrich-Wright, J., Fenton, R., Greguric, A., Hambley, T., Williams, P. (2002). The stereospecific synthesis of lambda-alpha-{dipyrido[3,2-a:2'3'-c]-(6,7,8,9-tetrahydro)phenazine[N,N'-di(2-picolyl)-2,5-dimethyl-2S,5S-diaminocyclohexane]ruthenium(II)} and related beta-isomers. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 24, 4666-4671.
  • Hambley, T., Katsifis, A., Knott, R., Mattner,, F., Dikic, B. (2002). The Structures of Imidazenil and Iodoimidazenil. Australian Journal of Chemistry: an international journal for chemical science, 55(11), 737-739.
  • Field, L., Hambley, T., Humphrey, P., Masters, A., Turner, P. (2002). X-ray Crystal Structure of (eta5-Pentaphenylcyclopentadienyl){1-(eta5/6-phenyl)-2,3,4,5-tetraphenylcyclopentadienyl}iron(II), [Fe(eta5-C5Ph5){eta5/6-C6H5)C5Ph4}], a Linkage Isomer of Decaphenylferrocene. Inorganic Chemistry, 41(18), 4618-4620.
  • Hambley, T., Turner, P., Jackson, T., Kojima,, M., Knott,, R., Lambrecht,, R. (2001). 6,6,9,9-tetramethyl-1,2,5,6,9,9a-hexahydro-imidazo[2,1-d][1,2,5]dithiazepin-1-ium triiodide. Acta Crystallographica. Section E: Structure Reports Online, E57, 315-317.
  • Hall, B., Hanrahan, J., Johnston, G., Hambley, T., Hibbs, D. (2001). 6-Methylflavone. Acta Crystallographica. Section E: Structure Reports Online, E57.
  • Platts, J., Hibbs, D., Hambley, T., Hall, M. (2001). Calculation of the hydrophobicity of platinum drugs. Journal of Medicinal Chemistry, 44(3), 472-474.
  • Weder, J., Hambley, T., Kennedy, B., Lay, P., Rich, A., Foran, G. (2001). Determination of the structures of antiinflammatory copper(II) dimers of indomethacin by multiple-scattering analyses of X-ray absorption fine structure data. Inorganic Chemistry, 40, 1295-1302.
  • Headlam, H., Weeks, C., Turner, P., Hambley, T., Lay, P. (2001). Dinuclear chromium(V) amino acid complexes from the reduction of chromium(VI) in the presence of amino acid ligands: XAFS characterization of a chromium(V) amino acid complex. Inorganic Chemistry, 40, 5097-5105.
  • Cham, S., Diakos, C., Ellis, L., Fenton, R., Munk, V., Hambley, T., Messerle, B. (2001). Isomer formation in the binding of [PtCl2(cis-cyclohexane-1,3-diamine)] to oligonucleotides and the X-ray crystal structure of [PtCl2(cis-cyclohexane-1,3-diamine)].dimethylformamide. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2001, 2769-2774.
  • Hambley, T., Lindoy, L., Reimers, J., Turner, P., Wei, G., Widmer-Cooper, A. (2001). Macrocyclic ligand design. X-ray, DFT and solution studies of the effect of N-methylation and N-benzylation of 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane on its affinity for selected transition and post-transition metal ions. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2001, 614-620.
  • Hambley, T., Jones, A. (2001). Molecular mechanics modelling of Pt/nucleotide and Pt/DNA interactions. Coordination Chemistry Reviews, 212, 35-59.
  • Wong, P., Davies, M., Hambley, T. (2001). Oxidation of [PtIICl2(ethane-1,2-diamine-N,N'dicarboxylic Acid)] and Ligand Ring Closure in the Platinum(IV) Oxidation State. Australian Journal of Chemistry: an international journal for chemical science, 54, 303-306.
  • Hambley, T. (2001). Platinum binding to DNA: Structural controls and consequences. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2001, 2711-2718.
  • Field, L., Soler, L., Buys, I., Hambley, T., Messerle, B. (2001). Polypyrazolylmethane complexes of ruthenium. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2001, 1959-1965.
  • Morgan, Y., Turner, P., Kennedy, B., Hambley, T., Lay, P., Biffin, J., Regtop, H., Warwick, B. (2001). Preparation and characterization of dinuclear copper-indomethacin anti-inflammatory drugs. Inorganica Chimica Acta, 324, 150-161.
  • Hambley, T., Ling, E., Munk, V., Davies, M. (2001). Steric control of stereoselective interactions between the platinum(II) complex [PtCl2(1,4-diazacycloheptane)] and DNA: Comparison with cis-[PtCl2(NH3)2] and [PtCl2(ethane-1,2-diamine)] using DNA binding and molecular modeling studies. Journal of Biological Inorganic Chemistry, 6(5-6), 534-542.
  • Hambley, T., Habtemariam,, A., Parkinson, J., Margiotta, N., Parsons, S., Sadler, P. (2001). Structure and dynamics of a platinum(II) aminophosphine complex and its nucleobase adducts. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2001, 362-372.
  • Davies, M., Diakos, C., Messerle, B., Hambley, T. (2001). Structure, stability, and interconversion barriers of the rotamers of cis-[PtIICl2(quinoline)2] and cis-[[PtIICl2(3-bromoquinoline)(quinoline)] from X-ray crystallography, NMR spectroscopy and molecular mechanics evidence. Inorganic Chemistry, 40, 3048-3054.
  • Giannikopoulos, G., Carter, J., Fenton, R., Hambley, T. (2001). The synthesis of ethane-1,2-diamine-N,N'-bis(methylenephosphonic) acid and its platinum(II) complex, Bis{ethane-1,2-diamine-N,N'-bis(methylenephosphonato)}platinum(II). Australian Journal of Chemistry: an international journal for chemical science, 54, 127-130.
  • Liu, X., Kassiou, M., Christie, M., Hambley, T. (2001). Trishomocubanes: requirements for sigma receptor binding and subtype selectivity. Australian Journal of Chemistry: an international journal for chemical science, 54, 31-36.
  • Burns, C., Field, L., Hambley, T., Lin, T., Ridley, D., Turner, P., Wilkinson, M. (2001). X-ray crystal structural determination of copper(II)-nitrilotriacetic acid-Bis(N-methylimidazol-2-yl)ketone ternary complex. ARKIVOC, vii, 157-165.
  • Codd, R., Levina, A., Zhang, L., Hambley, T., Lay, P. (2000). Characterization and X-ray absorption spectroscopic studies of bis[quinato(2)]oxochromate(V). Inorganic Chemistry, 39(5), 990-997.

Conferences

  • Hambley, T. (2009). Improving anticancer drug penetration in solid tumours (Invited lecture). 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
  • Hambley, T., Gui, X. (2009). Investigations into the electrochemical properties of Pt(IV) agents. 14th International Conference on Bioinorganic Chemistry.
  • Zhang, J., Bryce, N., Hambley, T. (2009). The penetration and accumulation of anti-tumour platinum(II) complexes in spheroid tumour models. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
  • Bryce, N., Zhang, J., Hambley, T. (2009). Visualising drug diffusion in a 3-dimensional tumour spheroid model system. 100th Annual Meeting of the American Association for Cancer Research, USA: N/A.
  • Yamamoto, N., Bryce, N., Danos, S., Hambley, T. (2009). Visualising the uptake of fluorescently tagged cobalt chaperones in solid tumour models. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
  • Hambley, T., Bonin, A., Davies, N., Dillon, C., Weder, J., Kennedy, B., Lay, P., Morgan, Y., Zhou, Q., Biffin, J., et al (2001). Metal complexes of non-steroidal anti-inflammatory drugs: An opportunity yet to be realised. 10th International Conference on Bioinorganic Chemistry, : Ads & Adea.
  • Dillon, C., Davies, N., Hambley, T., Kennedy, B., Lay, P., Zhou, Q., Stampfl, A., Cai, Z., Lai, B., Biffin, J., et al (2001). Micro-SRIXE and micro-XANES analysis of carcinogens and anti-inflammatory drugs in mammalian cells. 10th International Conference on Bioinorganic Chemistry, : Ads & Adea.
  • Hall, M., Dillon, C., Hambley, T., Davies, M., Price, A. (2001). Reactions and reduction of platinum(IV) anticancer complexes. 10th International Conference on Bioinorganic Chemistry, : Ads & Adea.

Patents

  • Hawkett, B., Hambley, T., Bryce, N., Pham, T., Jain, N. (2012). School of Chemistry, The University of Sydney. Patent No. WO2012142669.

2013

  • Renfrew, A., Bryce, N., Hambley, T. (2013). Delivery and release of curcumin by a hypoxia-activated cobalt chaperone: a XANES and FLIM study. Chemical Science, 4(9), 3731-3739. [More Information]
  • Zhang, J., Bonnitcha, P., Wexselblatt, E., Klein, A., Najajreh, Y., Gibson, D., Hambley, T. (2013). Facile preparation of mono-, di- and mixed-carboxylato platinum(IV) complexes for versatile anticancer prodrug design. Chemistry: A European Journal, 19(5), 1672-1676. [More Information]
  • Chen, C., Zhang, J., Aitken, J., Hambley, T. (2013). Influence of equatorial and axial carboxylato ligands on the kinetic inertness of platinum(IV) complexes in the presence of ascorbate and cysteine and within DLD-1 cancer cells. Journal of Medicinal Chemistry, 56(21), 8757-8764. [More Information]
  • Roberts, M., Pham, T., Doan, J., Fraser, B., Hambley, T., Greguric, I. (2013). Radiosynthesis of [18F]-ethynyl-4-fluorobenzene for click conjugation. Journal of Labelled Compounds and Radiopharmaceuticals, 56(S1), P091-P091.
  • Bryce, N., Pham, T., Fong, N., Jain, N., Pan, E., Whan, R., Hambley, T., Hawkett, B. (2013). The composition and end-group functionality of sterically stabilized nanoparticles enhances the effectiveness of co-administered cytotoxins. Biomaterials Science, 1(12), 1260-1272. [More Information]

2012

  • Hawkett, B., Hambley, T., Bryce, N., Pham, T., Jain, N. (2012). School of Chemistry, The University of Sydney. Patent No. WO2012142669.
  • Bonnitcha, P., Kim, B., Hocking, R., Clegg, J., Turner, P., Neville, S., Hambley, T. (2012). Cobalt complexes with tripodal ligands: Implications for the design of drug chaperones. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 41(37), 11293-11304. [More Information]
  • Yamamoto, N., Renfrew, A., Kim, B., Bryce, N., Hambley, T. (2012). Dual Targeting of Hypoxic and Acidic Tumor Environments with a Cobalt(III) Chaperone Complex. Journal of Medicinal Chemistry, 55(24), 11013-11021. [More Information]
  • Yamamoto, N., Bryce, N., Metzler-Nolte, N., Hambley, T. (2012). Effects of enzymatic activation on the distribution of fluorescently tagged MMP-2 cleavable peptides in cancer cells and spheroids. Bioconjugate chemistry, 23(6), 1110-1118. [More Information]
  • Zhang, J., Bryce, N., Lanzirotti, A., Chen, C., Paterson, D., De Jonge, M., Howard, D., Hambley, T. (2012). Getting to the core of platinum drug bio-distributions: the penetration of anti-cancer platinum complexes into spheroid tumour models. Metallomics, 4(11), 1209-1217. [More Information]
  • Zhang, J., Wexselblatt, E., Hambley, T., Gibson, D. (2012). Pt(IV) analogs of oxaliplatin that do not follow the expected correlation between electrochemical reduction potential and rate of reduction by ascorbate. Chemical Communications, 48(6), 847-849. [More Information]
  • Hall, M., Daly, H., Zhang, J., Zhang, M., Alderden, R., Pursche, D., Foran, G., Hambley, T. (2012). Quantitative measurement of the reduction of platinum(IV) complexes using X-ray absorption near-edge spectroscopy (XANES). Metallomics, 4(6), 568-575. [More Information]
  • Failes, T., Battle, A., Chen, C., Cullinane, C., Woods, R., Elliott, R., Deacon, G., Hambley, T. (2012). Structural and anticancer properties of hydrogen bonded diphenyl phosphate adducts of Pt(IV) complexes: The importance of pKa matching. Journal of Inorganic Biochemistry, 115, 220-225. [More Information]
  • Guo, S., Mason, D., Turland, S., Lawrenz, E., Kelly, L., Fallon, G., Gatehouse, B., Bond, A., Deacon, G., Battle, A., Hambley, T., et al (2012). Systematic differences in electrochemical reduction of the structurally characterized anti-cancer platinum(IV) complexes [Pt{((p-HC6F4)NCH2)2}-(pyridine)2Cl2], [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)2], and [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)Cl]. Journal of Inorganic Biochemistry, 115(2012), 226-239. [More Information]
  • Zhang, J., Bryce, N., Siegele, R., Carter, E., Paterson, D., De Jonge, M., Howard, D., Ryan, C., Hambley, T. (2012). The use of spectroscopic imaging and mapping techniques in the characterisation and study of DLD-1 cell spheroid tumour models. Integrative Biology, 4(9), 1072-1080. [More Information]

2011

  • Wolf, S., Huynh, T., Bryce, N., Hambley, T., Wakelin, L., Stewart, B., Catchpoole, D. (2011). Intracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cells. BMC Cell Biology, 12(36), 1-11. [More Information]
  • Yadav, P., Beveridge, R., Blay, J., Boyd, A., Chojnacka, M., Decken, A., Deshpande, A., Gardiner, M., Hambley, T., Hughes, M., New, E., et al (2011). Platinum-oxazoline complexes as anti-cancer agents: syntheses, characterisation and initial biological studies. MedChemComm (Medicinal Chemistry Communications), 2(4), 274-277. [More Information]
  • Daly, H., Hall, M., Failes, T., Zhang, M., Foran, G., Hambley, T. (2011). Stabilization of Triam(m)inechloridoplatinum Complexes by Oxidation to Pt(IV). Australian Journal of Chemistry: an international journal for chemical science, 64(3), 273-278. [More Information]
  • Norman, J., Hambley, T. (2011). Targeting strategies for metal-based therapeutics. In Professor Enzo Alessio (Eds.), Bioinorganic Medicinal Chemistry, (pp. 49-78). Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Cubo, L., Hambley, T., Sanz Miguel, P., Carnero, A., Navarro-Ranninger, C., Quiroga, A. (2011). The preparation and characterization of trans-platinum(IV) complexes with unusually high cytotoxicity. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 40(2), 344-347. [More Information]
  • Kim, B., Hambley, T., Bryce, N. (2011). Visualising the hypoxia selectivity of cobalt(III) prodrugs. Chemical Science, 2(11), 2135-2142. [More Information]

2010

  • Ma, Y., Bryce, N., Whan, R., Xiao, L., Li, K., Ruys, A., Hambley, T., Boughton, P. (2010). Growth of DLD-1 Colon Cancer Cells on Variotis™ Scaffolds of Controlled Porosity: A Preliminary Study. Journal of Biomimetics, Biomaterials, and Tissue Engineering, 8, 79-89. [More Information]
  • Bonin, A., Yanez, J., Fukuda, C., Teng, X., Dillon, C., Hambley, T., Lay, P., Davies, N. (2010). Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats. Cancer Chemotherapy and Pharmacology, 66(4), 755-764. [More Information]
  • Battle, A., Bond, A., Chow, A., Daniels, D., Deacon, G., Hambley, T., Junk, P., Mason, D., Wang, J. (2010). Syntheses and structures of N-polyfluorophenyl- and N,N'-bis(polyfluorophenyl)ethane-1,2-diaminato(1- or 2-)platinum(II) complexes. Journal of Fluorine Chemistry, 131(11), 1229-1236.

2009

  • Bryce, N., Zhang, J., Whan, R., Yamamoto, N., Hambley, T. (2009). Accumulation of an anthraquinone and its platinum complexes in cancer cell spheroids: The effect of charge on drug distribution in solid tumour models. Chemical Communications, 2009 (19), 2673-2675.
  • Whan, R., Messerle, B., Hambley, T. (2009). Binding of [Pt(1C3)(dien)]2+ to the duplex DNA oligonucleotide 5'-d(TGGCCA)-3': The effect of an appended positive charge on the orientation and location of anthraquinone intercalation. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2009 (6), 932-939.
  • Er, H., Hambley, T. (2009). Enantioselectivity and stereoselectivity in the reactions of the enantiomers of the platinum complex [PtCl(2)(ahaz)] (ahaz = 3(R)- or 3(S)-aminohexahydroazepine) with DNA. Journal of Inorganic Biochemistry, 103(2), 168-173. [More Information]
  • New, E., Roche, C., Madawala, R., Zhang, J., Hambley, T. (2009). Fluorescent analogues of quinoline reveal amine ligand loss from cis and trans platinum(II) complexes in cancer cells. Journal of Inorganic Biochemistry, 103(8), 1120-1125. [More Information]
  • Diakos, C., Messerie, B., Murdoch, P., Parkinson, J., Sadler, P., Fenton, R., Hambley, T. (2009). Identification by NMR spectroscopy of the two stereoisomers of the platinum complex [PtCl2(S-ahaz)] (S-ahaz = 3(S)-aminohexahydroazepine) bound to a DNA 14-mer oligonucleotide. NMR evidence of structural alteration of a platinated A x T-rich 14-mer DNA duplex. Inorganic Chemistry, 48(7), 3047-56. [More Information]
  • Diakos, C., Messerle, B., Murdoch, P., Parkinson, J., Sadler, P., Fenton, R., Hambley, T. (2009). Identification by NMR spectroscopy of the two steroisomers of the platinum complex [PtCl2(S-ahaz)] (S-ahaz = 3(S)-aminohexahydroazepine) bound to a DNA 14-mer oligonucleotide. NMR evidence of structural alteration of a platinated A.T-rich 14-mer DNA duplex. Inorganic Chemistry, 48(7), 3047-3056.
  • Hambley, T. (2009). Improving anticancer drug penetration in solid tumours (Invited lecture). 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
  • Hambley, T., Gui, X. (2009). Investigations into the electrochemical properties of Pt(IV) agents. 14th International Conference on Bioinorganic Chemistry.
  • New, E., Duan, R., Zhang, J., Hambley, T. (2009). Investigations using fluorescent ligands to monitor platinum(IV) reduction and platinum(II) reactions in cancer cells. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2009 (16), 3092-3101.
  • Clarke, A., Yamamoto, N., Jensen, P., Hambley, T. (2009). Iron(III) complexes of fluorescent hydroxamate ligands: preparation, properties, and cellular processing. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2009 (48), 10787-10798.
  • Hambley, T. (2009). Is anticancer drug development heading in the right direction? Cancer Research, 69(4), 1259-1262.
  • Comba, P., Hambley, T., Martin, B. (2009). Molecular Modeling of Inorganic Compounds: Third, Completely Revised and Enlarged Edition. Federal Republic of Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Zhang, J., Whan, R., Hambley, T. (2009). Platinum anticancer drugs, chemical biology of. In Natanya Civjan (Eds.), Wiley Encyclopaedia of Chemical Biology, (pp. 721-730). Hoboken, New Jersey, USA: John Wiley & Sons.
  • Klein, A., Hambley, T. (2009). Platinum drug distribution in cancer cells and tumors. Chemical Reviews, 109(10), 4911-4920.
  • Diakos, C., Zhang, M., Beale, P., Fenton, R., Hambley, T. (2009). Synthesis, characterisation and in vitro cytotoxicity studies of a series of chiral platinum(II) complexes based on the 2-aminomethylpyrrolidine ligand: X-ray crystal structure of [PtC12(R-dimepyrr)] (R-dimepyrr = N-dimethyl-2(R)-aminomethylpyrrolidine). European Journal of Medicinal Chemistry, 44(7), 2807-2814. [More Information]
  • Hambley, T. (2009). Targeted cancer therapeutics response. Cancer Research, 69(4), 1267-1267.
  • Zhang, J., Bryce, N., Hambley, T. (2009). The penetration and accumulation of anti-tumour platinum(II) complexes in spheroid tumour models. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
  • Bryce, N., Zhang, J., Hambley, T. (2009). Visualising drug diffusion in a 3-dimensional tumour spheroid model system. 100th Annual Meeting of the American Association for Cancer Research, USA: N/A.
  • Yamamoto, N., Bryce, N., Danos, S., Hambley, T. (2009). Visualising the uptake of fluorescently tagged cobalt chaperones in solid tumour models. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.

2008

  • Davies, M., Hall, M., Berners-Price, S., Hambley, T. (2008). [(1)H, (15)N] Heteronuclear Single Quantum Coherence NMR Study of the Mechanism of Aquation of Platinum(IV) Ammine Complexes. Inorganic Chemistry, 47(17), 7673-7680.
  • Yamamoto, N., Danos, S., Bonnitcha, P., Failes, T., New, E., Hambley, T. (2008). Cellular uptake and distribution of cobalt complexes of fluorescent ligands. Journal of Biological Inorganic Chemistry, 13(6), 861-871. [More Information]
  • Hambley, T. (2008). Physiological Targeting to Improve Anticancer Drug Selectivity. Australian Journal of Chemistry: an international journal for chemical science, 61(9), 647-653.
  • Guenther, K., Hambley, T., Kassiou, M. (2008). Radiolabelled probes for imaging multidrug resistance using single photon emission tomography (SPECT) and positron emission tomography (PET). In Nicola Antonio Colabufo (Eds.), Multidrug Resistance: Biological and Pharmaceutical Advances in Antitumour Treatment, (pp. 291-320). India: Research Signpost.

2007

  • Hall, M., Mellor, H., Callaghan, R., Hambley, T. (2007). Basis for design and development of platinum(IV) anticancer complexes. Journal of Medicinal Chemistry, 50(15), 3403-3411.
  • Hall, M., Failes, T., Yamamoto, N., Hambley, T. (2007). Bioreductive activation and drug chaperoning in cobalt pharmaceuticals. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, (36), 3983-3990.
  • Hocking, R., Hambley, T. (2007). Database analysis of transition metal carbonyl bond lengths: Insight into the periodicity of pi back-bonding, sigma donation, and the factors affecting the electronic structure of the TM-C=O moiety. Organometallics, 26(11), 2815-2823.
  • Hambley, T. (2007). Developing new metal-based therapeutics: Challenges and opportunities. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2007 (43), 4929-4937.
  • Hocking, R., Deeth, R., Hambley, T. (2007). DFT study of the systematic variations in metal-ligand bond lengths of coordination complexes: The crucial role of the condensed phase. Inorganic Chemistry, 46(20), 8238-8244.
  • Alderden, R., Mellor, H., Modok, S., Hall, M., Sutton, S., Newville, M., Callaghan, R., Hambley, T. (2007). Elemental tomography of cancer-cell spheroids reveals incomplete uptake of both platinum(II) and platinum(IV) complexes. Journal of the American Chemical Society, 129(44), 13400-13401.
  • Hambley, T. (2007). Metal-based therapeutics. Science, 318(5855), 1392-1393.
  • Failes, T., Cullinane, C., Diakos, C., Yamamoto, N., Lyons, J., Hambley, T. (2007). Studies of a Cobalt(III) complex of the MMP inhibitor marimastat: A potential hypoxia-activated prodrug. Chemistry: A European Journal, 13(10), 2974-2982. [More Information]
  • Failes, T., Hambley, T. (2007). Towards bioreductively activated prodrugs: Fe(III) complexes of hydroxamic acids and the MMP inhibitor marimastat. Journal of Inorganic Biochemistry, 101, 396-403. [More Information]
  • Modok, S., Scott, R., Alderden, R., Hall, M., Mellor, H., Bohic, S., Roose, T., Hambley, T., Callaghan, R. (2007). Transport kinetics of four- and six-coordinate platinum compounds in the multicell layer tumour model. British Journal of Cancer, 97(2), 194-200.
  • Hall, M., Underwood, C., Failes, T., Foran, G., Hambley, T. (2007). Using XANES to monitor the oxidation state of cobalt complexes. Australian Journal of Chemistry: an international journal for chemical science, 60(3), 180-183.

2006

  • Alderden, R., Mellor, H., Modok, S., Hambley, T., Callaghan, R. (2006). Cytotoxic efficacy of an anthraquinone linked platinum anticancer drug. Biochemical Pharmacology, 71(8), 1136-1145. [More Information]
  • Diakos, C., Fenton, R., Hambley, T. (2006). DNA-binding and molecular mechanics modelling studies of the bulky chiral platinum(II) complex [PtCl2(mepyrr)] (mepyrr = N-methyl-2-aminomethylpyrrolidine). Journal of Inorganic Biochemistry, 100(12), 1965-1973. [More Information]
  • Costa, L., Hambley, T., Rocha, W., De Almeida, W., Dos Santos, H. (2006). Kinetics and structural aspects of the cisplatin interactions with guanine: A quantum mechanical description. International Journal of Quantum Chemistry, 106(9), 2129-2144. [More Information]
  • Failes, T., Hambley, T. (2006). Models of hypoxia activated prodrugs: Co(III) complexes of hydroxamic acids. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2006 (15), 1895-1901.
  • Battle, A., Choi, R., Hibbs, D., Hambley, T. (2006). Platinum(IV) analogues of AMD473 (cis-[PtCl2(NH3)(2-picoline)]): preparative, structural, and electrochemical studies. Inorganic Chemistry, 45(16), 6317-6322. [More Information]
  • Alderden, R., Hall, M., Hambley, T. (2006). The discovery and development of cisplatin. Journal of Chemical Education, 83(5), 728-734.
  • Hall, M., Alderden, R., Zhang, M., Beale, P., Cai, Z., Lai, B., Stampfl, A., Hambley, T. (2006). The fate of platinum(II) and platinum(IV) anti-cancer agents in cancer cells and tumours. Journal of Structural Biology, 155(1), 38-44. [More Information]
  • Bonnitcha, P., Hall, M., Underwood, C., Foran, G., Zhang, M., Beale, P., Hambley, T. (2006). XANES investigation of the Co oxidation state in solution and in cancer cells treated with Co(III) complexes. Journal of Inorganic Biochemistry, 100(5-6), 963-971. [More Information]

2005

  • Malina, J., Voitiskova, M., Brabec, V., Diakos, C., Hambley, T. (2005). DNA adducts of the enantiomers of the Pt(II) complexes of the ahaz ligand (ahaz=3-aminohexahydroazepine) and recognition of these adducts by HMG domain proteins. Biochemical and Biophysical Research Communications, 332(4), 1034-1041. [More Information]
  • Ramadan, S., Bonin, A., Kennedy, B., Hambley, T., Lay, P. (2005). Nuclear magnetic resonance analysis of indomethacin-induced gastric ulcers. Chemical Research in Toxicology, 18(2), 123-128.
  • Hocking, R., Hambley, T. (2005). Structural measures of element-oxygen bond covalency from the changes to the delocalisation of the carboxylate ligand. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2005 (5), 969-978.
  • Mellor, H., Hall, M., Hambley, T., Snelling, S., Modok, S., Jaffar, M., Callaghan, R. (2005). The influence of tumour microenvironmental factors on the efficacy of cisplatin and novel platinum(IV) complexes. Biochemical Pharmacology, 70(8), 1137-1146. [More Information]

2004

  • Hall, M., Martin, C., Ferguson, D., Phillips, R., Hambley, T., Callaghan, R. (2004). Comparative Efficacy Of Novel Platinum(IV) Compounds With Established Chemotherapeutic Drugs In Solid Tumour Models. Biochemical Pharmacology, 67(1), 17-30. [More Information]
  • Dillon, C., Hambley, T., Kennedy, B., Lay, P., Weder, J., Zhou, Q. (2004). Copper And Zinc Complexes As Antiinflammatory Drugs. In Astrid Sigel & Helmut Sigel (Eds.), Metal Ions in Biological Systems : Volume 41 : Metal Ions and their Complexes in Medication, (pp. 253-277). New York: Marcel Dekker.
  • Ramadan, S., Hambley, T., Kennedy, B., Lay, P. (2004). Nmr Spectroscopic Characterization Of Copper(Ii) And Zinc(Ii) Complexes Of Indomethacin. Inorganic Chemistry, 43(9), 2943-2946.
  • Rendina, L., Hambley, T. (2004). Platinum. In D. E. Fenton (Eds.), Comprehensive Coordination Chemistry II : From biology to nanotechnology. Volume 6: Transition Metal groups 9-12, (pp. 673-745). Amsterdam: Elsevier.
  • Hall, M., Dolman, R., Hambley, T. (2004). Platinum(Iv) Anticancer Complexes. In Astrid Sigel & Helmut Sigel (Eds.), Metal Ions in Biological Systems: Volume 42. Metal Complexes in Tumor Diagnosis and as Anticancer Agents, (pp. 297-322). New York: Marcel Dekker.
  • Allan, R., Greenwood, J., Hambley, T., Hanrahan, J., Hibbs, D., Itani, S., Tran, H., Turner, P. (2004). Studies On Pyridazine Azide Cyclisation Reactions. Organic and Biomolecular Chemistry, 2(12), 1782-8-1788.
  • Hall, M., Amjadi, S., Zhang, M., Beale, P., Hambley, T. (2004). The mechanism of action of platinum(IV) complexes in ovarian cancer cell lines. Journal of Inorganic Biochemistry, 98, 1614-1624. [More Information]
  • Levina, A., Codd, R., Foran, G., Hambley, T., Maschmeyer, T., Masters, A., Lay, P. (2004). X-Ray Absorption Spectroscopic Studies Of Chromium(V/Iv/Iii)2-Ethyl-2-Hydroxybutanoato(2-/1-) Complexes. Inorganic Chemistry, 43(3), 1046-1055.

2003

  • Failes, T., Diakos, C., Underwood, C., Hambley, T., Cullinane, C., Lyons, J. (2003). Can metal complexes serve as hypoxia activated prodrugs? Investigations of a Co(III) complex of the MMP inhibitor marimastat. Journal of Inorganic Biochemistry, 96(1), 128.
  • Field, L., Messerle, B., Rehr, M., Soler, L., Hambley, T. (2003). Cationic iridium(I) complexes as catalysts for the alcoholysis of silanes. Organometallics, 22(12), 2387-2395.
  • Hall, M., Hambley, T., Beale, P., Zhang, M., Dillon, C., Foran, G., Stampfl, A., Lai, B. (2003). Does platinum(IV) survive in tumour cells? Journal of Inorganic Biochemistry, 96(1), 141.
  • Waller, M., Hibbs, D., Overgaard, J., Hanrahan, J., Hambley, T. (2003). Flavone. Acta Crystallographica. Section E: Structure Reports Online, 59(6), o767-o768.
  • Dillon, C., Hambley, T., Kennedy, B., Lay, P., Zhou, Q., Davies, N., Biffen, R., Regtop, H. (2003). Gastrointestinal Toxicity, Antiinflammatory Activity, and Superoxide Dismutase Activity of Copper and Zinc Complexes of the Antiinflammatory Drug Indomethacin. Chemical Research in Toxicology, 16(1), 28-37.
  • Alderden, R., Hall, M., Amjadi, S., Hambley, T., Beale, P., Zhang, M., Lai, M., Stampfl, A. (2003). Increasing the cellular accumulation of platinum(IV) complexes. Journal of Inorganic Biochemistry, 96(1), 89.
  • Failes, T., Hambley, T. (2003). Insights into Pt(II)-hydroxamate bonding through the crystal structures of DMSO complexes. Australian Journal of Chemistry: an international journal for chemical science, 56(1), 45-48.
  • Bulluss, G., Waller, M., Hambley, T. (2003). Investigation of rotamers about the Pt-N7 bonds in bulky [Pt(d(GpG))(diamine)] complexes. Journal of Inorganic Biochemistry, 96(1), 108.
  • Munk, V., Diakos, C., Ellis, L., Fenton, R., Hambley, T., Messerle, B. (2003). Investigations into the interactions between DNA and conformationally constrained pyridylamineplatinum(II) analogues of AMD473. Inorganic Chemistry, 42(11), 3582-3590.
  • Bernhardt, P., Hambley, T., Lawrance, G., Maeder, M., Wilkes, E. (2003). Isomers of 1,4,8,11-tetraazacyclotetradecane-6,13-dicarboxylate characterized as cobalt(III) complexes. Australian Journal of Chemistry: an international journal for chemical science, 56(7), 679-684.
  • Bulluss, G., Waller, M., Hambley, T. (2003). Mechanism of action of platinum complex binding to DNA. Journal of Inorganic Biochemistry, 96(1), 109.
  • Brown, K., Geue, R., Hambley, T., Hockless, D., Rae, A., Sargeson, A. (2003). Specificity in template syntheses of hexaaza-macrobicyclic cages: [Pt(Me5-tricosatrieneN6)]4+ and [Pt(Me5-tricosaneN6)]4+. Organic and Biomolecular Chemistry, 1, 1598-1608.
  • Hocking, R., Hambley, T. (2003). Structural insights into transition-metal carbonyl bonding. Chemical Communications, 2003 (13), 1516-1517.
  • Hocking, R., Hambley, T. (2003). Structural measure of metal-ligand covalency from the bonding in carboxylate ligands. Inorganic Chemistry, 42(9), 2833-2835.
  • Hall, M., Dillon, C., Zhang, M., Beale, P., Cai, Z., Lai, B., Stampfl, A., Hambley, T. (2003). The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells. Journal of Biological Inorganic Chemistry, 8(7), 726-732. [More Information]
  • Hibbs, D., Overgaard, J., Hambley, T., Gatti, C. (2003). The electron density in flavones I. Baicalein. New Journal of Chemistry, 27(9), 1392-1398.
  • Failes, T., Hall, M., Hambley, T. (2003). The first examples of platinum amine hydroxamate complexes: structures and biological activity. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2003 (8), 1596-1600.
  • Underwood, C., Min, D., Lyons, J., Hambley, T. (2003). The interaction of metal ions and Marimastat with matrix metalloproteinase 9. Journal of Inorganic Biochemistry, 95(2-3), 165-170.
  • Ellis, L., Perkins, D., Turner, P., Hambley, T. (2003). The preparation and charcterisation of cyclam/anthraquinone macrocyle/intercalator complexes and their interactions with DNA. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2003 (13), 2728-2736.
  • Giannikopoulos, G., Teo, C., Hall, M., Fenton, R., Hambley, T. (2003). The synthesis and in vitro cytotoxicity of two trans-platinum complexes of heterocyclic amines. Australian Journal of Chemistry: an international journal for chemical science, 56(7), 685-689.
  • Zhou, Q., Hambley, T., Kennedy, B., Lay, P. (2003). XAFS studies of anti-inflammatory dinuclear and mononuclear Zn(II) complexes of indomethacin. Inorganic Chemistry, 42(25), 8557-8566.
  • Hall, M., Foran, G., Zhang, M., Beale, P., Hambley, T. (2003). XANES determination of the platinum oxidation state distribution in cancer cells treated with platinum(IV) anticancer agents. Journal of the American Chemical Society, 125(25), 7524-7525.

2002

  • Hotze, A., Chen, Y., Hambley, T., Parsons, S., Kratochwil, N., Parkinson, J., Munk, V., Sadler, P. (2002). Cis-[PtCl2(NH3){2-(2-hydroxyethyl)pyridine}] - an Analogue of the Anticancer Drug AMD473: Unusual Hydrolysis Rates and pKa Values for the Diaqua Adduct. European Journal of Inorganic Chemistry, 2002 (5), 1035-1039.
  • Weder, J., Dillon, C., Hambley, T., Kennedy, B., Lay, P., Biffin, J., Regtop, H., Davies, N. (2002). Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized. Coordination Chemistry Reviews, 232(1-2), 95-126.
  • Battle, A., Deacon, G., Dolman, R., Hambley, T. (2002). Electrochemistry, Protein Binding and Crystal Structures of Platinum(II) and Platinum(IV) Carboxylato Complexes. Australian Journal of Chemistry: an international journal for chemical science, 55(11), 699-704.
  • Davies, M., Wong, P., Battle, A., Haddad, G., McKeage, M., Hambley, T. (2002). Examination of the effects of oxidation and ring closure on the cytotoxicities of the platinum complexes of N-(2-hydroxyethyl)ethane-1,2-diamine and ethane-1,2-diamine-N,N9-diacetic acid. Journal of Inorganic Biochemistry, 91(1), 205-211.
  • Hambley, T., Hibbs, D., Turner, P., Howard, S., Hursthouse, M. (2002). Insights into bonding and hydrogen bond directionality in thioacetamide from the experimental charge distribution. Journal of the Chemical Society Perkin Transactions 2, 2(2002), 235-239.
  • Munk, V., Cham, S., Fenton, R., Hocking, R., Hambley, T. (2002). Insights into the van der Waals Radius of Low-Spin Ni(II) from Molecular Mechanics Studies and the Crystal Structures of [Ni(cis-cyclohexane-1,3-diamine)2]Cl2, [Ni{(R)-5,5,7-trimethyl-1,4-diazacycloheptane}2]Cl2.H2O and [Ni(5,7-dimethyl-1,4-diazacyclohept. Australian Journal of Chemistry: an international journal for chemical science, 55(8), 523-529.
  • Field, L., Messerle, B., Soler, L., Hambley, T., Turner, P. (2002). Iron(II) complexes containing poly(1-pyrazolyl)methane ligands. Journal of Organometallic Chemistry, 655(1-2), 146-157.
  • Greguric, A., Greguric, I., Hambley, T., Aldrich-Wright, J., Collins, J. (2002). Minor groove intercalation of Delta-[Ru(Me2phen)2dppz]2+ to the hexanucleotide d(GTCGAC)2. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 10, 849-855.
  • Hall, M., Hambley, T. (2002). Platinum(IV) antitumour compounds: their bioinorganic chemistry. Coordination Chemistry Reviews, 232(1-2), 49-67.
  • Cullinane, C., Deacon, G., Drago, P., Hambley, T., Nelson, K., Webster, L. (2002). Preparation and cell growth inhibitory activity of [PtR2L2] (R=polyfluorophenyl, L2 = diene, cyclohexane-1,2-diamine (chxn) or cis-(dimethyl sulfoxide)2) and the X-ray crystal structure of [Pt(C6F5)2(cis-chxn)]. Journal of Inorganic Biochemistry, , 293-301.
  • Hocking, R., Hambley, T. (2002). Statistical and Molecular Mechanics Analysis of the Effects of Changing Donor Type on Bond Length in the Two Series [CoIIINnO6-n] and [NiIINnO6-n] (n = 0-6): A New Route to Bond-Stretch Parameters. Inorganic Chemistry, 41(10), 2660-2666.
  • Munk, V., Diakos, C., Messerle, B., Fenton, R., Hambley, T. (2002). Stereospecificity and Enantioselectivity in the Binding of the Platinum(II) Complex [PtCl2(tmdz)] (tmdz=5,5,7-Trimethyl-1,4-diazacycloheptane) to Dinucleotides and Oligonucleotides. Chemistry: A European Journal, 8(23), 5486-5493.
  • Hall, M., Failes, T., Hibbs, D., Hambley, T. (2002). Structural Investigations of Palladium(II) and Platinum(II) Complexes of Salicylhydroxamic Acid. Inorganic Chemistry, 41(5), 1223-1228.
  • Dolman, R., Deacon, G., Hambley, T. (2002). Studies of the binding of a series of platinum(IV) complexes to plasma proteins. Journal of Inorganic Biochemistry, 88(3-4), 260-267.
  • Wei, G., Hambley, T., Lawrance, G., Maeder, M. (2002). Synthesis and Complexation of a Chiral Sexidentate Pendant-Arm Macropolycyclic Polyamino Acid. Australian Journal of Chemistry: an international journal for chemical science, 55(10), 667-673.
  • Battle, A., Platts, J., Hambley, T., Deacon, G. (2002). Synthesis, spectroscopy, and theoretical studies of platinum(II) phosphate complexes. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, , 1898-1902.
  • Aldrich-Wright, J., Fenton, R., Greguric, A., Hambley, T., Williams, P. (2002). The stereospecific synthesis of lambda-alpha-{dipyrido[3,2-a:2'3'-c]-(6,7,8,9-tetrahydro)phenazine[N,N'-di(2-picolyl)-2,5-dimethyl-2S,5S-diaminocyclohexane]ruthenium(II)} and related beta-isomers. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 24, 4666-4671.
  • Hambley, T., Katsifis, A., Knott, R., Mattner,, F., Dikic, B. (2002). The Structures of Imidazenil and Iodoimidazenil. Australian Journal of Chemistry: an international journal for chemical science, 55(11), 737-739.
  • Field, L., Hambley, T., Humphrey, P., Masters, A., Turner, P. (2002). X-ray Crystal Structure of (eta5-Pentaphenylcyclopentadienyl){1-(eta5/6-phenyl)-2,3,4,5-tetraphenylcyclopentadienyl}iron(II), [Fe(eta5-C5Ph5){eta5/6-C6H5)C5Ph4}], a Linkage Isomer of Decaphenylferrocene. Inorganic Chemistry, 41(18), 4618-4620.

2001

  • Hambley, T., Turner, P., Jackson, T., Kojima,, M., Knott,, R., Lambrecht,, R. (2001). 6,6,9,9-tetramethyl-1,2,5,6,9,9a-hexahydro-imidazo[2,1-d][1,2,5]dithiazepin-1-ium triiodide. Acta Crystallographica. Section E: Structure Reports Online, E57, 315-317.
  • Hall, B., Hanrahan, J., Johnston, G., Hambley, T., Hibbs, D. (2001). 6-Methylflavone. Acta Crystallographica. Section E: Structure Reports Online, E57.
  • Platts, J., Hibbs, D., Hambley, T., Hall, M. (2001). Calculation of the hydrophobicity of platinum drugs. Journal of Medicinal Chemistry, 44(3), 472-474.
  • Weder, J., Hambley, T., Kennedy, B., Lay, P., Rich, A., Foran, G. (2001). Determination of the structures of antiinflammatory copper(II) dimers of indomethacin by multiple-scattering analyses of X-ray absorption fine structure data. Inorganic Chemistry, 40, 1295-1302.
  • Headlam, H., Weeks, C., Turner, P., Hambley, T., Lay, P. (2001). Dinuclear chromium(V) amino acid complexes from the reduction of chromium(VI) in the presence of amino acid ligands: XAFS characterization of a chromium(V) amino acid complex. Inorganic Chemistry, 40, 5097-5105.
  • Cham, S., Diakos, C., Ellis, L., Fenton, R., Munk, V., Hambley, T., Messerle, B. (2001). Isomer formation in the binding of [PtCl2(cis-cyclohexane-1,3-diamine)] to oligonucleotides and the X-ray crystal structure of [PtCl2(cis-cyclohexane-1,3-diamine)].dimethylformamide. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2001, 2769-2774.
  • Hambley, T., Lindoy, L., Reimers, J., Turner, P., Wei, G., Widmer-Cooper, A. (2001). Macrocyclic ligand design. X-ray, DFT and solution studies of the effect of N-methylation and N-benzylation of 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane on its affinity for selected transition and post-transition metal ions. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2001, 614-620.
  • Hambley, T., Bonin, A., Davies, N., Dillon, C., Weder, J., Kennedy, B., Lay, P., Morgan, Y., Zhou, Q., Biffin, J., et al (2001). Metal complexes of non-steroidal anti-inflammatory drugs: An opportunity yet to be realised. 10th International Conference on Bioinorganic Chemistry, : Ads & Adea.
  • Dillon, C., Davies, N., Hambley, T., Kennedy, B., Lay, P., Zhou, Q., Stampfl, A., Cai, Z., Lai, B., Biffin, J., et al (2001). Micro-SRIXE and micro-XANES analysis of carcinogens and anti-inflammatory drugs in mammalian cells. 10th International Conference on Bioinorganic Chemistry, : Ads & Adea.
  • Hambley, T., Jones, A. (2001). Molecular mechanics modelling of Pt/nucleotide and Pt/DNA interactions. Coordination Chemistry Reviews, 212, 35-59.
  • Hambley, T., Comba, P. (2001). Molecular Modeling of Inorganic Compounds. Germany: Wiley - V C H Verlag GmbH & Co. KGaA.
  • Wong, P., Davies, M., Hambley, T. (2001). Oxidation of [PtIICl2(ethane-1,2-diamine-N,N'dicarboxylic Acid)] and Ligand Ring Closure in the Platinum(IV) Oxidation State. Australian Journal of Chemistry: an international journal for chemical science, 54, 303-306.
  • Hambley, T. (2001). Platinum binding to DNA: Structural controls and consequences. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2001, 2711-2718.
  • Field, L., Soler, L., Buys, I., Hambley, T., Messerle, B. (2001). Polypyrazolylmethane complexes of ruthenium. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2001, 1959-1965.
  • Morgan, Y., Turner, P., Kennedy, B., Hambley, T., Lay, P., Biffin, J., Regtop, H., Warwick, B. (2001). Preparation and characterization of dinuclear copper-indomethacin anti-inflammatory drugs. Inorganica Chimica Acta, 324, 150-161.
  • Hall, M., Dillon, C., Hambley, T., Davies, M., Price, A. (2001). Reactions and reduction of platinum(IV) anticancer complexes. 10th International Conference on Bioinorganic Chemistry, : Ads & Adea.
  • Hambley, T., Ling, E., Munk, V., Davies, M. (2001). Steric control of stereoselective interactions between the platinum(II) complex [PtCl2(1,4-diazacycloheptane)] and DNA: Comparison with cis-[PtCl2(NH3)2] and [PtCl2(ethane-1,2-diamine)] using DNA binding and molecular modeling studies. Journal of Biological Inorganic Chemistry, 6(5-6), 534-542.
  • Hambley, T., Habtemariam,, A., Parkinson, J., Margiotta, N., Parsons, S., Sadler, P. (2001). Structure and dynamics of a platinum(II) aminophosphine complex and its nucleobase adducts. Dalton Transactions: an international journal of inorganic, organometallic and bioinorganic chemistry, 2001, 362-372.
  • Davies, M., Diakos, C., Messerle, B., Hambley, T. (2001). Structure, stability, and interconversion barriers of the rotamers of cis-[PtIICl2(quinoline)2] and cis-[[PtIICl2(3-bromoquinoline)(quinoline)] from X-ray crystallography, NMR spectroscopy and molecular mechanics evidence. Inorganic Chemistry, 40, 3048-3054.
  • Giannikopoulos, G., Carter, J., Fenton, R., Hambley, T. (2001). The synthesis of ethane-1,2-diamine-N,N'-bis(methylenephosphonic) acid and its platinum(II) complex, Bis{ethane-1,2-diamine-N,N'-bis(methylenephosphonato)}platinum(II). Australian Journal of Chemistry: an international journal for chemical science, 54, 127-130.
  • Liu, X., Kassiou, M., Christie, M., Hambley, T. (2001). Trishomocubanes: requirements for sigma receptor binding and subtype selectivity. Australian Journal of Chemistry: an international journal for chemical science, 54, 31-36.
  • Burns, C., Field, L., Hambley, T., Lin, T., Ridley, D., Turner, P., Wilkinson, M. (2001). X-ray crystal structural determination of copper(II)-nitrilotriacetic acid-Bis(N-methylimidazol-2-yl)ketone ternary complex. ARKIVOC, vii, 157-165.

2000

  • Codd, R., Levina, A., Zhang, L., Hambley, T., Lay, P. (2000). Characterization and X-ray absorption spectroscopic studies of bis[quinato(2)]oxochromate(V). Inorganic Chemistry, 39(5), 990-997.

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