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Gut microbiome

Getting to the guts of weight control

Discovering the influence of our gut microorganisms over our metabolism, immune and nervous systems, our food choices and other behaviours.

We have brought together a collaborative team of microbiologists, neuropathologists, nutrition scientists and behavioural psychologists to determine the nature and extent of the influence of gut microorganisms on the overall functioning of the human body.

We know our gut houses an enormous population of microorganisms, with each of us having an individual gut micro-organism ‘profile’. The activity of these micro-organisms modifies the chemical composition of the food we eat, influencing how our bodies use it to produce energy and fight disease. Despite their microscopic size, these tiny living things hold substantial sway over the body’s major regulatory control systems, including our metabolic, immune and nervous systems, and ultimately over our food choices and other behaviours.

Our multidisciplinary team is investigating exactly how our gut micro-organisms interact with the rest of our bodies.

We will correlate our findings to develop personalised lifestyle interventions that take into account each individual’s gut micro-organism profile, making successful weight management more achievable.

We envisage that this research will create a more personalised, nuanced understanding of the gut, and lead to specifically tailored plans for weight management.

  • Associate Professor Andrew Holmes, Medicine, University of Sydney, Project lead
  • Lise Mellor, Research support officer
  • Dr Kim Bell-Anderson, Science, University of Sydney
  • Professor Ian Caterson, Science, University of Sydney, Boden Institute of Obesity, Nutrition, Exercise & Eating Disorders
  • Julie Clarke
  • Feyza Colakoglu, European Molecular Biology Laboratory
  • Associate Professor Greg Cooney, Garvan Institute of Medical Research
  • Dr Liam Elbourne, Macquarie University
  • Clarissa Asha Febinia, Eijkman Institute
  • Dr Nick Fuller, Medicine, University of Sydney
  • Associate Professor Anandwardhan Hardikar, Medicine, University of Sydney
  • Dr Markus Hofer, Science, University of Sydney
  • Professor Jon Iredell, Medicine, University of Sydney
  • Chau Le
  • Elissa Liew, Royal North Shore Hospital and University of Technology, Sydney.
  • Dr Trevor Lockett, CSIRO
  • Sarafina Malik
  • Dr Sally Partridge, Medicine, University of Sydney, Westmead Clinical School
  • Professor Ian Paulsen, Macquarie University
  • Fleur Ponton, Macquarie University
  • Professor Peter Reeves, Science, University of Sydney
  • Professor Stephen Simpson, Science, University of Sydney
  • Professor Len Storlien, Medicine, University of Sydney
  • Ketut Suastika
  • Dr Herawati Sudoyo, Eijkman Institute
  • Dr David Topping, CSIRO
  • Ken Wilson
  • Laura Woolfenden
  • Mia Zeric, Science, University of Sydney