Intensive Care Medicine

Research Staff


The Critical Care Team (click on for larger view)

Clinical Professor Anthony McLean

Clinical Professor McLean

Professor Anthony McLean

The Nepean Hospital Critical Care Division has a very strong focus on research under the leadership of Clinical Professor Tony McLean. Due to the wide varieties of research interests and the increasing research activities, a special Critical Care Research Team was set-up to administer the research activities within the Division. The Team is chaired by Clinical Professor Tony McLean, and is run by Dr Stephen Huang and Dr Ian Seppelt. The Unit has a number of supporting staff, including research registrars, research nurses, data-managing nurses and sonographers. The research activities can be broadly divided into three main types: Clinical trials, clinical science research and quality improvement research.

In addition to clinical trials, Clinical Professor McLean’s special interests in clinical and physiological sciences research has resulted in the publications of a number of articles. The main research interests in this area are cardiovascular diseases, their diagnoses and treatments. One of the most powerful non-invasive tool to evaluate heart functions is echocardiography. Nepean ICU is recognized not only to be one of the birth places of intensive care echocardiography but also as a center of excellence in such applications. Refinement and exploration of new echocardiographic techniques are part of the many research themes.

The Nepean Department of Intensive Care Medicine research has attracted external fundings of more than a quarter of a million over the last 2 years. Such fundings are expected to increase in the following years. In recognizing Intensive Care Medicine as a specialized and unique area, the Critical Care Research Team welcome any interested individuals, with medical, nursing or science background, either to pursue a postgraduate research degree (PhD or MSc) or to collaborate research studies.

Research interests
  • Relationship between mean systemic pressure and acute renal failure
  • Pharmacogenetics in the critically ill patients
  • New biomarkers for cardiac dysfunction in the critically ill
  • Assessment of cardiac function and haemodynamics with ultrasound
  • The human enterobiome in critical illness
  • Ecological effects of antibiotics in critical illness
  • Right ventricular function in acute respiratory distress syndrome
  • Acute kidney injury and right ventricular function
  • Lactate infusion in out of hospital cardiac arrest
  • Lung ultrasound in acute heart failure
  • Immune dysfunction in sepsis
  • Aerobic glycolysis in leukocytes
  • Critical ill obstetric patients
  • Gene expression and genetic markers for sepsis

Associate Professor Stuart Lane


Associate Professor and Coordinator of Clinical Studies, Sydney Medical Program
Senior Lecturer in Intensive Care Medicine, Nepean Clinical School

Associate Professor Stuart Lane graduated Medical School at the University of Newcastle-upon-Tyne, UK. He commenced his appointment with Sydney Medical School in 2007 as a Senior Lecturer in Intensive Care Medicine, and Staff Specialist in Intensive Care Medicine at Nepean Hospital. He has a strong passion and decorated record for teaching, and has developed a national and international reputation in researching human experience using qualitative methodologies. He is also a part 1 and part 2 examiner for the College of Intensive Care Medicine (CICM), NSW CICM Supervisor of training, and deputy chair of the NSW CICM regional committee. He is a keen swimmer and has just swum the English Channel in September.

Associate Professor Lane is Coordinator of clinical studies and Chair of the Personal and Professional Development theme (PPD) for the Sydney Medical Program. He also teaches and examines students in all stages of the SMP both at central faculty and Nepean Clinical School, where he has been awarded teacher of the year for 6 years.

Current Projects

Associate Professor Lane's primary research interest is phenomenological analysis of human experience. He is commencing Australia's first Intensive Care Unit (ICU) follow-up clinic, developing knowledge and theory to optimise patient experience and management whilst they are in the ICU and beyond. His PhD thesis 'Saying Sorry: Doctors' experiences of open disclosure after medication error. A phenomenological study using simulation', illuminated the clinical experiencesof medical interns during the open disclosure process. It also explored the utility of high-fidelity simulation to develop critical refection and cognitive resilience.

Associate Professor Stephen Huang


Associate Professor & Principal Research Fellow
Intensive Care Medicine, Nepean Clinical School

Associate Professor Stephen Huang established an internationally recognised reputation in critical care ultrasound. He is an Associate Professor and a Principal Research Fellow of the Discipline of Intensive Care Medicine, Nepean Clinical School. He received his PhD from University of Hong Kong in 1990, and worked at the Chinese University Medical School as a lecture until 1995 after which he migrated to Australia. Since then, he obtained further professional qualifications, including sonography and biostatistics. He is also a lawyer of the Supreme Court of NSW. He is the Director of the Nepean Institute of Critical Care Education and Research, and also served in the Curriculum Board (CCPU) at the Australasian Society for Ultrasound in Medicine.

He has a wide range of research experience, and is interested in critical care research. More specifically, his works examine the use of ultrasound in assessing the cardiac function and haemodynamics of critically ill patients.

Research Interests

Intensive care medicine, intensive care echocardiography, respiratory physiology/medicine, cardiovascular physiology/medicine, medical legal issues

Read More:
A/P Stephen Huang

Telephone +61 2 47342320
Fax +61 2 47343134



Associate Professor Benjamin Tang is the head of the Nepean Genomic Research Group.

He is a critical care physician and immunogeneticist and leads the translational research program at the Department of Intensive Care Medicine, Nepean Hospital.

Dr Tang received his medical training at Sydney Medical School. He is a Fellow of College of Intensive Care Medicine of Australia and New Zealand and was awarded the Matt Spence medal from the College of Intensive Care Medicine in recognition of his early research work.

Dr Tang was also trained in clinical epidemiology at the School of Public Health, University of Sydney and has published several highly cited systemic reviews and meta-analyses in Lancet, Lancet Infectious Diseases and Critical Care Medicine.

Dr Tang undertook his PhD work in the laboratory of geneticist Ian Dawes. His research in the genomic study of sepsis led to him receiving the prestigious NHMRC Post-doctoral fellowship. During his post-doctoral years, he worked with immunogeneticist David Booth to investigate the immune response of influenza infection. This work has recently led to him receiving the prestigious Clive and Vera Ramaciotti Establishment Grant for young scientist.

Currently, his research includes viral immunology, sepsis and development of molecular diagnostics and focuses on translating the science of gene discovery into the development of new molecular diagnostics and novel immunotherapy.

Read More:Associate Professor Benjamin Tang

Research Interests:
  • The impact of genetic polymorphism on drug response in critically ill patients.
  • The monitoring of immuno-suppression in patients with sepsis.
  • The profiling of metabolic pathways derrangements in immune cells in severe infection.
  • The use of interferon derived biomarker in the diagnosis of severe pneumonia.
  • The use of genomic biomarker in the management of influenza infection.
  • The role of plasmacytoid dendritic cell activity in the pathogenesis of viral infection.
  • The use of dendritic cell vaccination therapy in septic patients with immunosuppression
  • Dendritic cell derived therapy and its mechanism of action in the in vitro setting.
  • The mechanism of immune cell dysregulation in viral and bacterial pneumonia.

Contact details

PO Box 63
Derby St
Penrith, NSW 2751

Tel: (02) 4734 2490
Fax: (02) 4734 3134
Email: Novea Riley