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Professor Georges Grau

Professor of Vascular Immunology
Pathology, School of Medical Sciences
Bosch Institute

Cancer research network

China studies centre

Telephone +61 2 9036 3260
Fax +61 2 9036 3177

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Biographical details

2006 - present: Professor, Chair of Vascular Immunology, Department of Pathology, School of Medical Sciences, Faculty of Medicine, University of Sydney

1999 - 2006: Professeur des Universites (Physiologie, section 40), Universite de la Mediterranee 1998 - 1999: Research Associate, CNRS, Prof. D. Raoult, Marseille 1997 - 1998: Invited Professor, Department of Pathology, University of Regensburg 1995 - 1997: Chef de Clinique Scientifique, University of Geneva 1992: Privat - Docent (Agregation de l'Enseignement Superieur), Faculty of Medicine, University of Geneva 1991 - 1995: Maitre de'Enseignement et de Recherche at the WHO Centre and at the Department of Pathology, University of Geneva 1989 - 1991: Charge de Recherche, Departement de Pathologie, University of Geneva 1984 - 1988: Assistant en Medecine Fondamentale, Department of Pathology, University of Geneva 1984: M.D. Thesis, University of Geneva 1983: Candidate-Specialist in Internal Medicine, Universite de Liege 1982 - 1995: Research Associate, World Health Organisation, Immunology Research and Training Centre, Prof. P.H. Lambert, University of Geneva, Switzerland 1981 - 1982: Post-Doctoral Fellow, Institut de Pathologie Cellulaire, Prof. M. Bessis, Hopital du Kremlin-Bicetre, Paris, France 1979 - 1983: Resident, Department of Internal Medicine, Prof. H. van Cauwenberghe, Hopital Universitaire de Baviere, Liege 1972 - 1979: Doctor of Medicine (with High Distinction), University of Liege

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Research interests

Immunopathology of microvascular lesions, particularly of cerebral and pulmonary complications of infectious and auto-immune diseases, especially in cerebral malaria, septic shock and multiple sclerosis. Analysis of the cellular and molecular mechanisms of the interactions between microvascular endothelial cells and cells of the immune system. Experience in various in vivo and in vitro experimental systems as well as in clinical studies. More recently, focus on the neurovascular lesion of murine and human cerebral malaria, using co-culture model systems involving brain endothelium, P. falciparum infected erythrocytes, as well as circulating cells, particularly platelets and monocytes.

Additional keywords: endothelium; cytokines; platelets; microparticles; brain diseases; cerebral malaria; sepsis; septic shock

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Selected grants

2016

  • AINST - Flagship Program MS; Grau G; Australian Institute of Nanoscience and Technology (AINST)/Flagship Program.
  • Antigen Presentation In Cerebral Malaria Pathogenesis: A Role For Brain Microvascular Endothelium And Microparticles; Grau G, Combes V, Hunt N, Saunders B; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Real time bio-impedance measurement of biological samples: Electrical Cell-substrate Impedance Spectroscopy ECIS Zθ equipped with Ibidi Pump System; Traini D, Young P, Zreiqat H, Grau G, Ammit A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Advanced NanoSight NS300 System; Halliday G, Richardson D, Chan K, Grau G, Shackel N; University of Sydney/Equipment Grant.

2015

  • Characterising splenic myeloid responses to CNS pathogens; Mitchell A, Grau G, Fazekas de St Groth B, King N, Palendira U; University of Sydney/Internal Scheme.
  • Portable Infrared Spectroscopy Equipment for Cancer Diagnosis, Research into Prevention of Cancer by Understanding the Role of Diet, and for Drug Development and Studies on Efficacy; Lay P, Richardson D, Banati R, Biro M, Bebawy M, Graeber M, Grau G, Hambley T, New E, Carter E; Cancer Institute New South Wales/Equipment Grant.
  • Trans-endothelial migration of leucocytes of Multiple Sclerosis (MS) patients across an in vitro blood-brain barrier model; Hawke S, Zinger A, Grau G; Medical Advances Without Animals/Research Grants.
  • CJDSGN Memorial Awards for research in CJD related diseases; Grau G, Hawke S; CJD Support Group Network/Donation.
  • Live Cell Accessories for Raman and FTIR Imaging; Lay P, Hawkins C, Grau G, Witting P, Chan K; DVC Research/Equipment Grant.
  • Developing and testing pro-thrombotic conjugates for brain AVMs; Grau G; National Health and Medical Research Council (NHMRC)/Project Grants.

2014

  • Characterizing plasma microparticle content in multiple sclerosis patients; Wheway J, Zinger A, Hawke S, Grau G, Combes V; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2013

  • Deciphering the role of microparticles from discrete origins in the pathogenesis of cerebral malaria using a novel in vitro system to replace animal models.; Grau G, Combes V; Medical Advances Without Animals/Research Grants.
  • Wide field super-resolution microscopy with ground state depletion - Exploring nanoscopic life in chronic diseases; Braet F, Weiss A, King N, Dos Remedios C, Traini D, Graeber M, Murphy C, Grau G, Soon L, Newsome T, Goldsbury C, Lovelace M, Gorrell M, Pollock C; DVC Research/Equipment Grant.

2012

  • The astrocyte: a crossroads in cerebral malaria pathogenesis; Hunt N, Ball H, Grau G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The link between the angiogenesis of live birth and cancer: a lizard model; Thompson M, Murphy C, Grau G; Australian Research Council (ARC)/Discovery Projects (DP).
  • Microparticles are pathogenic elements in the pathophysiology of cerebral malaria; Combes V, Grau G, Wheway J; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Australia-Thai Symposium - Infectious diseases and immunology: translating research into practice; Grau G, Campbell D, Freckelton L, Kakakios A, Kulthanan T, Tribuddharat C; DVC International/IPDF Grant.
  • BD Influx 3-L Cell Sorter; Britton W, King N, Grau G, Weninger W, McCaughan G, Slobedman B, Saunders B, West N, Triccas J, Abendroth A, Combes V, Bowen D, Shackel N, Ellis M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Microparticles and Cellular Signalling During Tuberculosis Infection; Saunders B, Britton W, Grau G, Combes V; DVC Research/Bridging Support Grant.

2011

  • Microparticles and Selective Trait Dominance in Multidrug Resistant Cancers; Bebawy M, Grau G, Combes V; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Fluorescence microscopy with optical tweezers: imaging cellular responses; Weninger W, Gunning P, Grau G, King N, Grewal T, Soon L; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Microparticles and Selective Trait Dominance in Multidrug Resistant Cancers; Bebawy M, Grau G, Combes V; National Health and Medical Research Council (NHMRC)/Project Grants.
  • DEEP SEQUENCING OF GLIOMA DERIVED MICROP ARTICLES; Grau G, Suter C; Cancer Council New South Wales/Innovator Grant.
  • Endothelial cells and their microparticles as immunomodulators in cerebral malaria; Wheway J, Grau G; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • The involvement of the kynurenine pathway in blood brain barrier disruption and its relevance for neuroinflammatory diseases; Guillemin G, Combes V, Grau G, Brew B; National Health and Medical Research Council (NHMRC)/Project Grants.

2010

  • Deciphering molecular mechanisms of endothelial vesiculation; Grau G; DVC Research/Bridging Support Grant.
  • A 5-D Correlative Imaging Platform: Combining the Strengths of Light and Electron Microscopy; Braet F, Mitchell H, Soon L, Overall R, Day D, Waterhouse P, Marc J, Conigrave A, Weiss A, Newsome T, Meikle S, Goetz J, Goldsbury C, Hambley T, Ramzan I, Young P, Traini D, Grewal T, Fleming S, Murphy C, Grau G, Weninger W, Dos Remedios C, Wimmer-Kleikamp S, Munroe P, Stevens-Kalceff M, Foster L, Killingsworth M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2009

  • Panthetine, a Putative Treatment for Cerebral Malaria; Sanchez-Perez A, Grau G; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • 7-laser BD LSR-II and Cellomics Array Scan VTi to Enhance Capability and Throughput for the NSW Advanced Cytometry Facility; King N, Weninger W, Gunning P, Fazekas de St Groth B, Campbell I, Christopherson R, Black J, Mason R, Richardson D, Halliday G, Grau G, Gandevia S, Kachigian L, Geczy C, Jessup W, Vadas M, Britton W, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • StreamLineTM Plus- Rapid Chemical Mapping; Lay P, Grau G, Richardson D, Hambley T, Witting P, Carter E; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Pathophysiological alterations of brain microvascular endothelial cells in cerebral malaria; Grau G, Sanchez-Perez A, Combes V; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas de St Groth B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Microparticle Mediated Transfer of P-glycoprotein in Conferring Multidrug Resistance in Cancer; Bebawy M, Grau G, Combes V; Cancer Council New South Wales/Research Project Grants.
  • Cytokine and macrophage determinants of pulmonary inflammation during tuberculosis; Saunders B, Britton W, Grau G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Novel coatings for orthopaedic implants; Grau G, Little D, Zreiqat H, Dunstan C; National Health and Medical Research Council (NHMRC)/Project Grants.

2008

  • Dysregulation of cytokine networks: a key determinant of the pathogenesis of cerebral malaria; Hunt N, Ball H, Grau G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Dako ACIS 111 Cellular Image Acquisition and Analysis System; Hambly B, Bao B, Bishop A, Black J, Campbell I, Dong Q, Gorrell M, Grau G, Hunt N, King N, Markham R, Marsh D, McDonald K, McLennan S, Rodgers K, Seth D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials and Medical Research; Lay P, McNaughton D, Maschmeyer T, Potts D, Swain M, Grau G, Sorrell T, Ramzan I, Beardall J, Bernard C, Marshall C, Dutkiewicz A, Penny D, Wood B, Yang W, Soon L, Traini D, Carter E; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Pathogenic Roles of Microparticles in Cerebal Malaria; Grau G; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological Materials, and Medical Research; Bernard C, Marshall C, Wood B, Potts D, Penny D, Dutkiewicz A, Grau G, Sorrell T, Swain M, Yang W, Soon L, Lay P, McNaughton D, Maschmeyer T, Ramzan I, Beardall J, Traini D, Carter E; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Dako ACIS III Cellular Image Acquisition and Analysis System; Gorrell M, Grau G, Bishop A, Black J, Campbell I, McLennan S, Rodgers K, Seth D, Marsh D, Dong Q, Hambly B, Bao B, King N, Markham R, McDonald K, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).

2007

  • PHERSAstar and POLARstar optima multifunctional plate readers with robotic high throughout screening system for multi-disciplinary cancer research; Grau G, Hunt N, Richardson D; Cancer Institute New South Wales/Research Grant.
  • Total internal reflectance fluorescence microscope (TIRFM); Soon L, Rendina L, Braet F, Weiss A, Grau G, Lyons G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Cell AnalySYS Facility Platform, Epic XL MCL Flow Cytometer FC-500, AutoMACS magnetic cell sorter and Geminin EM spectrofluorometer; Grau G; University of Sydney/Major Equipment Grant.
  • Odyssey Infrared imaging system; Grau G, Sorrell T; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • MFB cell analysis facility platform, EpicXL MCL flow cytometer, autoMACS magnetic cell sorter and Ge; Grau G; DEST/Major Equipment.
  • Pathogenic Role of Microparticles in Cerebral Malaria; Grau G, De Souza J, Burger D, Ryffel B, Renia L, Gouado I, Molyneux M, Combes V, Chimini G; European Commission/Framework Programme.
  • PHERAstar and POLARstar Optima multi-functional plate readers with robotic high throughput screening system for multi-disciplinary cancer research; Halliday G, Ho J, Conigrave A, Iland H, Lee C, Joshua D, Cook D, Richardson D, Reichardt J, Grau G, Lovejoy D, Hunt N, King N, Mason R, Murphy C, Sharland A, Assinder S, Dong Q, Bishop A; Cancer Institute New South Wales/Infrastructure Grant.
  • Microparticles as effectors of microvascular alterations in brain inflammation; Grau G, Hunt N; Australian Research Council (ARC)/Discovery Projects (DP).
  • Relationship between cell-cell interactions and disease severity in patients with cerebral malaria; Grau G, Cook D, Hunt N; National Health and Medical Research Council (NHMRC)/Project Grants.
  • The role of von Willebrand Factor (vWF) in malaria pathogenesis; Grau G, Craig A; Wellcome Trust (UK)/Research Support.
  • Statins, microparticles and cerebral malaria; Grau G; Rebecca Cooper Foundation/Rebecca Cooper Foundation.
  • Twister microplate handle: A robotic system for the Bruker HTS-XT infrared module.; Lay P, Hunt N, Grau G, Sorrell T, Witting P; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2006

  • University of Sydney - USYD Professorial Research fellowship; Grau G; University of Sydney/Professorial Research fellowship.
  • Pathophysiology of malaria-associated lung disease; Hunt N, Ball H, Grau G, Anstey N; National Health and Medical Research Council (NHMRC)/Project Grants.

2005

  • Platelets in pathogenesis of cerebral malaria; Grau G, Bunn J, van Rooien J, Craig A; Wellcome Trust (UK)/Research Support.
  • Pathophysiology of the micro-vascular lesion during cerebral malaria: Grau. Study of the interactions between endothelium, red blood cells and circulating cells.; Grau G, Buguet B, Fusai T; GENERAL DIRECTION OF ARMY (France)/Research Support.
  • Vesiculation and Endothelial Thrombosis: molecular and cellular mechanisms and role in the inter-cellular communication; Grau G; Foundation of France/Research Support.

2004

  • TBA; Grau G, Molyneux M, Roberts D; Wellcome Trust (UK)/Research Support.
  • TBA; Grau G; FONDATION RECHERCHE MEDICALE/Equipment.
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Selected publications

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Book Chapters

  • Grau, G., Hunt, N. (2014). Cytokines and Some of Their Effector Mechanisms in Cerebral Malaria Pathogenesis. In M. Hommel and P. G. Kremsner (Eds.), Encyclopedia of Malaria, (pp. 1-11). New York: Springer. [More Information]
  • Combes, V., El-Assaad, F., Grau, G. (2011). Immunopathology and pathophysiology of cerebral malaria. In Mauro Bendinelli, Herman Friedman and Andreas Seyfang (Eds.), Infectious Agents and Pathogenesis. tba: Springer Publishing Company.
  • Combes, V., Grau, G. (2007). Microvascular endothelium and cerebral malaria. In William Aird (Eds.), The Endothelium: A Comprehensive Reference. CRC Press.
  • Combes, V., Lou, J., Grau, G. (2007). The endothelium in cerebral malaria - Both a target cell and a major player. In William Aird (Eds.), Endothelial Biomedicine, (pp. 1303-1310). United States: Cambridge University Press.
  • Combes, V., Grau, G. (2006). Cytokines in defence and pathology of the central nervous system. In Richard M. Ransohoff, Etty N. Benveniste (Eds.), Cytokines and the CNS - 2nd Edition, (pp. 243-268). United States: CRC Press.

Journals

  • O'Regan, N., Gegenbauer, K., O'Sullivan, J., Maleki, S., Brophy, T., Chion, A., Fallon, P., Grau, G., Budde, U., Smith, O., et al (2016). A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria. Blood, 127(9), 1192-1201. [More Information]
  • Sorrell, T., Juillard, P., Djordjevic, J., Kaufman-Francis, K., Dietmann, A., Milonig, A., Combes, V., Grau, G. (2016). Cryptococcal transmigration across a model brain blood-barrier: evidence of the Trojan horse mechanism and differences between Cryptococcus neoformans var grubii strain H99 and C gattii strain R265. Microbes and Infection, 18(1), 57-67. [More Information]
  • Ghadiri, M., Mamlouk, M., Spicer, P., Jarolimek, W., Grau, G., Young, P., Traini, D. (2016). Effect of polyunsaturated fatty acids (PUFAs) on airway epithelial cells' tight junction. Pulmonary Pharmacology and Therapeutics, 40, 30-38. [More Information]
  • Wassmer, S., Grau, G. (2016). Platelets as pathogenetic effectors and killer cells in cerebral malaria. Expert Review of Hematology, 9(6), 515-517. [More Information]
  • Carvalho, T., Morahan, B., John von Freyenda, S., Boeuf, P., Grau, G., Garcia-Bustosa, J., Doerig, C. (2016). The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation. Molecular and Biochemical Parasitology, 208(1), 2-15. [More Information]
  • Ampawong, S., Chaisri, U., Viriyavejakul, P., Prapansilp, P., Grau, G., Turner, G., Pongponratn, E. (2015). A potential role for interleukin-33 and γ-epithelium sodium channel in the pathogenesis of human malaria associated lung injury. Malaria Journal, 14(1), 1-15. [More Information]
  • Bucur, O., Almasan, A., Zubarev, R., Friedman, M., Nicolson, G., Sumazin, P., Leabu, M., Nikolajczyk, B., Avram, D., Kunej, T., Richardson, D., Grau, G., et al (2015). An updated h-index measures both the primary and total scientific output of a researcher. Discoveries, 3(3), 1-6. [More Information]
  • Kam, A., Li, K., Razmovski-Naumovsk, V., Nammi, S., Chan, K., Grau, G., Li, G. (2015). Curcumin Reduces Tumour Necrosis Factor-Enhanced Annexin V-Positive Microparticle Release in Human Vascular Endothelial Cells. Journal of Pharmacy and Pharmaceutical Sciences, 18(4), 424-433.
  • Hochman, S., Madaline, T., Wassmer, S., Mbale, E., Choi, N., Seydel, K., Whitten, R., Varughese, J., Grau, G., Kamiza, S., et al (2015). Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection. MBIO, 6(5), 1-12. [More Information]
  • Latham, S., Tiberti, N., Gokoolparsadh, N., Holdaway, K., Couraud, P., Grau, G., Combes, V. (2015). Immuno-analysis of microparticles: probing at the limits of detection. Scientific Reports, 5, 1-13. [More Information]
  • Hackett, M., Aitken, J., El Assaad, F., McQuillan, J., Carter, E., Ball, H., Tobin, M., Paterson, D., De Jonge, M., Siegele, R., Grau, G., Hunt, N., Lay, P., et al (2015). Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sites. Science Advances, 6(4), 7-16. [More Information]
  • Cohen, A., Combes, V., Grau, G. (2015). MicroRNAs and Malaria – A Dynamic Interaction Still Incompletely Understood. Journal of Neuroinfectious Diseases, 6(1), 1-12. [More Information]
  • Whittington, C., Grau, G., Murphy, C., Thompson, M. (2015). Unusual angiogenic factor plays a role in lizard pregnancy but is not unique to viviparity. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 324B (2), 152-158. [More Information]
  • Danastas, K., Combes, V., Lindsay, L., Grau, G., Thompson, M., Murphy, C. (2015). VEGF111: New insights in tissue invasion. Frontiers in Physiology, 6, 1-5. [More Information]
  • Grau, G., Thompson, M., Murphy, C. (2015). VEGF: Inflammatory paradoxes. Pathogens and Global Health, 109(6), 253-254. [More Information]
  • Khaw, L., Ball, H., Mitchell, A., Grau, G., Stocker, R., Golenser, J., Hunt, N. (2014). Brain endothelial cells increase the proliferation of Plasmodium falciparum through production of soluble factors. Experimental Parasitology, 145(1), 34-41. [More Information]
  • Jaiswal, R., Grau, G., Bebawy, M. (2014). Cellular communication via microparticles: role in transfer of multidrug resistance in cancer. Future Oncology, 10(4), 655-669. [More Information]
  • Hunt, N., Ball, H., Hansen, A., Khaw, L., Guo, J., Bakmiwewa, S., Mitchell, A., Combes, V., Grau, G. (2014). Cerebral malaria: gamma-interferon redux. Frontiers in Cellular and Infection Microbiology, 4, 1-12. [More Information]
  • Ampawong, S., Chaisri, U., Viriyavejakul, P., Nontprasert, A., Grau, G., Pongponratn, E. (2014). Electron microscopic features of brain edema in rodent cerebral malaria in relation to glial fibrillary acidic protein expression. International Journal of Clinical and Experimental Pathology, 7(5), 2056-2067.
  • Wheway, J., Latham, S., Combes, V., Grau, G. (2014). Endothelial Microparticles Interact with and Support the Proliferation of T Cells. The Journal of Immunology, 193(7), 3378-3387. [More Information]
  • Wen, B., Combes, V., Bonhoure, A., Weksler, B., Couraud, P., Grau, G. (2014). Endotoxin-Induced Monocytic Microparticles Have Contrasting Effects on Endothelial Inflammatory Responses. PloS One, 9(3), e91597. [More Information]
  • El-Assaad, F., Combes, V., Grau, G., Jambou, R. (2014). Potential Efficacy of Citicoline as Adjunct Therapy in Treatment of Cerebral Malaria. Antimicrobial Agents and Chemotherapy, 58(1), 602-605. [More Information]
  • El Assaad, F., Wheway, J., Hunt, N., Grau, G., Combes, V. (2014). Production, fate and pathogenicity of plasma microparticles in murine cerebral malaria. PLoS Pathogens, 10(3), 1-14. [More Information]
  • Pai, S., Qin, J., Cavanagh, L., Mitchell, A., El-Assaad, F., Jain, R., Combes, V., Hunt, N., Grau, G., Weninger, W. (2014). Real-Time Imaging Reveals the Dynamics of Leukocyte Behaviour during Experimental Cerebral Malaria Pathogenesis. PLoS Pathogens, 10(7), 1-17. [More Information]
  • Jaiswal, R., Luk, F., Dalla, P., Grau, G., Debawy, M. (2013). Breast Cancer-Derived Microparticles Display Tissue Selectivity in the Transfer of Resistance Proteins to Cells. PloS One, 8(4), 1-10. [More Information]
  • Roseblade, A., Luk, F., Rawling, T., Ung, A., Grau, G., Bebawy, M. (2013). Cell-Derived Microparticles: New Targets in the Therapeutic Management of Disease. Journal of Pharmacy and Pharmaceutical Sciences, 16(2), 238-253. [More Information]
  • Latham, S., Chaponnier, C., Dugina, V., Couraud, P., Grau, G., Combes, V. (2013). Cooperation between beta- and gamma-cytoplasmic actins in the mechanical regulation of endothelial microparticle formation. The FASEB Journal, 27(2), 672-683. [More Information]
  • Razakandrainibe, R., Combes, V., Grau, G., Jambou, R. (2013). Crossing the wall: The opening of endothelial cell junctions during infectious diseases. The International Journal of Biochemistry and Cell Biology, 45(7), 1165-1173. [More Information]
  • El-Assaad, F., Wheway, J., Mitchell, A., Lou, J., Hunt, N., Combes, V., Grau, G. (2013). Cytoadherence of Plasmodium berghei-infected red blood cells to murine brain and lung microvascular endothelial cells in vitro. Infection and Immunity, 81(11), 3984-3991. [More Information]
  • Dietmann, A., Millonig, A., Combes, V., Couraud, P., Kachlany, S., Grau, G. (2013). Effects of aggregatibacter actinomycetemcomitans leukotoxin on endothelial cells. Microbial Pathogenesis, 61 - 62, 43-50. [More Information]
  • Khaw, L., Ball, H., Golenser, J., Combes, V., Grau, G., Wheway, J., Mitchell, A., Hunt, N. (2013). Endothelial Cells Potentiate Interferon-γ Production in a Novel Tripartite Culture Model of Human Cerebral Malaria. PloS One, 8(7), 1-13. [More Information]
  • Li, C., Eaton, S., Young, P., Lee, M., Shuttleworth, R., Humphreys, D., Grau, G., Combes, V., Bebawy, M., Gong, J., Buckland, M., et al (2013). Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells. RNA Biology, 10(8), 1333-1344. [More Information]
  • Lee, J., Siegele, R., Pastuovic, Z., Hackett, M., Hunt, N., Grau, G., Cohen, D., Lay, P. (2013). Light and heavy ion beam analysis of thin biological sections. Nuclear Instruments and Methods in Physics Research. Section B, 306, 129-133. [More Information]
  • Gong, J., Luk, F., Jaiswal, R., George, A., Grau, G., Bebawy, M. (2013). Microparticle drug sequestration provides a parallel pathway in the acquisition of cancer drug resistance. European Journal of Pharmacology, 721(1-3), 116-125. [More Information]
  • Walters, S., Kieckbusch, J., Nagalingam, G., Swain, A., Latham, S., Grau, G., Britton, W., Combes, V., Saunders, B. (2013). Microparticles from Mycobacteria-Infected Macrophages Promote Inflammation and Cellular Migration. The Journal of Immunology, 190(2), 669-677. [More Information]
  • Lu, J., Luk, F., Gong, J., Jaiswal, R., Grau, G., Bebawy, M. (2013). Microparticles mediate MRP1 intercellular transfer and the re-templating of intrinsic resistance pathways. Pharmacological Research, 76, 77-83. [More Information]
  • Liu, H., Zhang, W., Jia, Y., Yu, Q., Grau, G., Peng, L., Ran, Y., Yang, Z., Deng, H., Lou, J. (2013). Single-cell clones of liver cancer stem cells have the potential of differentiating into different types of tumor cells. Cell Death and Disease, 4(10), 1-11. [More Information]
  • Wheway, J., Obeid, S., Couraud, P., Combes, V., Grau, G. (2013). The brain microvascular endothelium supports t cell proliferation and has potential for alloantigen presentation. PloS One, 8(1), 1-8. [More Information]
  • Razakandrainibe, R., Pelleau, S., Grau, G., Jambou, R. (2012). Antigen presentation by endothelial cells: what role in the pathophysiology of malaria? Trends in Parasitology, 28(4), 151-160. [More Information]
  • Grau, G., Craig, A. (2012). Cerebral malaria pathogenesis: revisiting parasite and host contributions. Future Microbiology, 7(2), 291-302. [More Information]
  • Faille, D., El Assaad, F., Mitchell, A., Alessi, M., Chimini, G., Fusai, T., Grau, G., Combes, V. (2012). Endocytosis and intracellular processing of platelet microparticles by brain endothelial cells. Journal of Cellular and Molecular Medicine, 16(8), 1731-1738. [More Information]
  • Hackett, M., Lee, J., El Assaad, F., McQuillan, J., Carter, E., Grau, G., Hunt, N., Lay, P. (2012). FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: General implications for disease neurochemistry. ACS Chemical Neuroscience, 3(12), 1017-1024. [More Information]
  • Jaiswal, R., Luk, F., Gong, J., Mathys, J., Grau, G., Bebawy, M. (2012). Microparticle conferred microRNA profiles - implications in the transfer and dominance of cancer traits. Molecular Cancer, 11, 1-13. [More Information]
  • Jaiswal, R., Gong, J., Sambasivam, S., Combes, V., Mathys, J., Davey, R., Grau, G., Bebawy, M. (2012). Microparticle-associated nucleic acids mediate trait dominance in cancer. The FASEB Journal, 26(1), 420-429. [More Information]
  • Gong, J., Jaiswal, R., Mathys, J., Combes, V., Grau, G., Bebawy, M. (2012). Microparticles and their emerging role in cancer multidrug resistance. Cancer Treatment Reviews, 38(3), 226-234. [More Information]
  • Combes, V., Guillemin, G., Chan-Ling, T., Hunt, N., Grau, G. (2012). The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes. Trends in Parasitology, 28(8), 311-319. [More Information]
  • Hafalla, J., Claser, C., Couper, K., Grau, G., Renia, L., De Souza, J., Riley, E. (2012). The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. PLoS Pathogens, 8(2), 1-12. [More Information]
  • Craig, A., Grau, G., Janse, C., Kazura, J., Milner, D., Barnwell, J., Turner, G., Langhorne, J. (2012). The Role of Animal Models for Research on Severe Malaria. PLoS Pathogens, 8(2), 1-9. [More Information]
  • Hackett, M., McQuillan, J., El Assaad, F., Aitken, J., Levina, A., Cohen, D., Siegele, R., Carter, E., Grau, G., Hunt, N., Lay, P. (2011). Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis. The Analyst, 136(14), 2941-2952. [More Information]
  • Nantakomol, D., Dondorp, A., Krudsood, S., Udomsangpetch, R., Pattanapanyasat, K., Combes, V., Grau, G., White, N., Viriyavejakul, P., Day, N., et al (2011). Circulating red cell-derived microparticles in human malaria. The Journal of Infectious Diseases, 203(5), 700-706. [More Information]
  • Hempel, C., Combes, V., Hunt, N., Kurtzhals, J., Grau, G. (2011). CNS Hypoxia Is More Pronounced in Murine Cerebral than Noncerebral Malaria and is Reversed by Erythropoietin. The American Journal of Pathology, 179(4), 1939-1950. [More Information]
  • McQuillan, J., Mitchell, A., Ho, Y., Combes, V., Ball, H., Golenser, J., Grau, G., Hunt, N. (2011). Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria. International Journal for Parasitology, 41(2), 155-163. [More Information]
  • El Assaad, F., Hempel, C., Combes, V., Mitchell, A., Ball, H., Kurtzhals, J., Hunt, N., Mathys, J., Grau, G. (2011). Differential MicroRNA Expression in Experimental Cerebral and Noncerebral Malaria. Infection and Immunity, 79(6), 2379-2384. [More Information]
  • Saggu, R., Faille, D., Grau, G., Cozzone, P., Viola, A. (2011). In the eye of experimental cerebral malaria. The American Journal of Pathology, 179(3), 1104-1109. [More Information]
  • Jambou, R., El Assaad, F., Combes, V., Grau, G. (2011). In vitro culture of Plasmodium berghei-ANKA maintains infectivity of mouse erythrocytes inducing cerebral malaria. Malaria Journal, 10(1), A346-1-A346-5. [More Information]
  • Hackett, M., Siegele, R., El Assaad, F., McQuillan, J., Aitken, J., Carter, E., Grau, G., Hunt, N., Cohen, D., Lay, P. (2011). Investigation of the mouse cerebellum using STIM and μ-PIXE spectrometric and FTIR spectroscopic mapping and imaging. Nuclear Instruments and Methods in Physics Research. Section B, 269(20), 2260-2263. [More Information]
  • Moxon, C., Grau, G., Craig, A. (2011). Malaria: modification of the red blood cell and consequences in the human host. British Journal of Haematology, 154(6), 670-679. [More Information]
  • Ling, Z., Combes, V., Grau, G., King, N. (2011). Microparticles as immune regulators in infectious disease - an opinion. Frontiers in Immunology, 2(67), 1-8. [More Information]
  • Barbier, M., Faille, D., Loriod, B., Textoris, J., Camus, C., Puthier, D., Flori, L., Wassmer, S., Victorero, G., Alessi, M., Grau, G., et al (2011). Platelets alter gene expression profile in human brain endothelial cells in an in vitro model of cerebral malaria. PloS One, 6(5), e19651-1-e19651-14. [More Information]
  • Ampawong, S., Combes, V., Hunt, N., Radford, J., Chan-Ling, T., Pongponratn, E., Grau, G. (2011). Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. International Journal of Clinical and Experimental Pathology, 4(6), 566-574. [More Information]
  • Hee, L., Dinudom, A., Mitchell, A., Grau, G., Cook, D., Hunt, N., Ball, H. (2011). Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice. International Journal for Parasitology, 41(1), 81-88. [More Information]
  • Wassmer, S., Moxon, C., Taylor, T., Grau, G., Molyneux, M., Craig, A. (2011). Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF. Cellular Microbiology Online, 13(2), 198-209. [More Information]
  • Pankoui Mfonkeu, J., Gouado, I., Fotso Kuate, H., Zambou, O., Combes, V., Grau, G., Amvam Zollo, P. (2010). Biochemical markers of nutritional status and childhood malaria severity in Cameroon. British Journal of Nutrition, 104(6), 886-892. [More Information]
  • Pankoui Mfonkeu, J., Gouado, I., Fotso Kuate, H., Zambou, O., Amvam Zollo, P., Grau, G., Combes, V. (2010). Elevated Cell-Specific Microparticles Are a Biological Marker for Cerebral Dysfunctions in Human Severe Malaria. PloS One, 5(10), e13415 - 1-e13415 - 9. [More Information]
  • Carpintero, R., Gruaz, L., Brandt, K., Scanu, A., Faille, D., Combes, V., Grau, G., Burger, D. (2010). HDL Interfere with the Binding of T Cell Microparticles to Human Monocytes to Inhibit Pro-Inflammatory Cytokine Production. PloS One, 5(7), e11869-1-e11869-8. [More Information]
  • Combes, V., El-Assaad, F., Faille, D., Jambou, R., Hunt, N., Grau, G. (2010). Microvesiculation and cell interactions at the brain-endothelial interface in cerebral malaria pathogenesis. Progress in Neurobiology, 91(2), 140-151. [More Information]
  • Hunt, N., Grau, G., Engwerda, C., Barnum, S., van der Heyde, H., Hansen, D., Schofield, L., Golenser, J. (2010). Murine cerebral malaria: the whole story. Trends in Parasitology, 26(6), 272-4. [More Information]
  • Couper, K., Barnes, T., Hafalla, J., Combes, V., Ryffel, B., Secher, T., Grau, G., Riley, E., De Souza, J. (2010). Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation. PLoS Pathogens, 6(1), e1000744-1-e1000744-13. [More Information]
  • Jambou, R., Combes, V., Mege-Jambou, M., Weksler, B., Couraud, P., Grau, G. (2010). Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions. PLoS Pathogens, 6(7), 1-13. [More Information]
  • Bridges, D., Bunn, J., Van Mourik, J., Grau, G., Preston, R., Molyneux, M., Combes, V., O'Donnell, J., De Laat, B., Craig, A. (2010). Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings. Blood, 115(7), 1472-1474. [More Information]
  • Mitchell, A., Pradel, L., Chasson, L., Van Rooijen, N., Grau, G., Hunt, N., Chimini, G. (2010). Technical Advance: Autofluorescence as a tool for myeloid cell analysis. Journal of Leukocyte Biology, 88(3), 597-603. [More Information]
  • Zhang, W., Wu, L., Liu, H., Ye, L., Xin, Y., Grau, G., Lou, J. (2009). Abnormal blood vessels formed by human liver cavernous hemangioma endothelial cells in nude mice are suitable for drug evaluation. Microvascular research, 78(3), 379-385. [More Information]
  • El-Assaad, F., Combes, V., Grau, G. (2009). Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases. The International Journal of Biochemistry and Cell Biology, 41(7), 1467-1470. [More Information]
  • Bruzzone, R., Dubois-Dalcq, M., Grau, G., Griffin, D., Kristensson, K. (2009). Infectious diseases of the nervous system and their impact in developing countries. P L o S Pathogens, 5(2), e1000199. [More Information]
  • Bebawy, M., Combes, V., Lee, E., Jaiswal, R., Gong, J., Bonhoure, A., Grau, G. (2009). Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells. Leukemia, 23(9), 1643-1649. [More Information]
  • Gouado, I., Pankoui Mfonkeu, J., Fotso, H., Zambou, O., Nguele, S., Combes, V., Grau, G., Amvam Zollo, P. (2009). Physiopathologic factors resulting in poor outcome in childhood severe malaria in Cameroon. The Pediatric Infectious Disease Journal, 28(12), 1081-1084. [More Information]
  • Faille, D., Combes, V., Mitchell, A., Fontaine, A., Juhan-Vague, I., Alessi, M., Chimini, G., Fusai, T., Grau, G. (2009). Platelet microparticles: a new player in malaria parasite cytoadherence to human brain endothelium. The F A S E B Journal, 23(10), 3449-3458. [More Information]
  • Faille, D., El Assaad, F., Alessi, M., Fusai, T., Combes, V., Grau, G. (2009). Platelet-endothelial cell interactions in cerebral malaria: The end of a cordial understanding. Thrombosis and Haemostasis, 102(6), 1093-1102. [More Information]
  • Bechah, Y., Capo, C., Grau, G., Raoult, D., Mege, J. (2009). Rickettsia prowazekii infection of endothelial cells increases leukocyte adhesion through alpha (v)beta(3) integrin engagement. Clinical Microbiology and Infection, 15(Suppl 2), 249-250. [More Information]
  • Larkin, D., de Laat, M., Jenkins, P., Bunn, J., Craig, A., Terraube, V., Preston, R., Donkor, C., Grau, G., Van Mourik, J., et al (2009). Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition. PLoS Pathogens, 5(3), 1-8. [More Information]
  • von zur Muhlen, C., Sibson, N., Peter, K., Campbell, S., Wilainam, P., Grau, G., Bode, C., Choudhury, R., Anthony, D. (2008). A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI. Journal of Clinical Investigation, 118(3), 1198-1207. [More Information]
  • Togbe, D., de Sousa, P., Fauconnier, M., Boissay, V., Fick, L., Scheu, S., Pfeffer, K., Menard, R., Grau, G., Doan, B., Hansen, A., Ball, H., Hunt, N., et al (2008). Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PloS One, 3(7), e2608-1-e2608-12. [More Information]
  • Pankoui Mfonkeu, J., Gouado, I., Fotso Kuate, H., Zambou, O., Grau, G., Combes, V., Amvam Zollo, P. (2008). Clinical presentation, haematological indices and management of children with severe and uncomplicated malaria in Douala, Cameroon. Pakistan Journal of Biological Sciences, 11(20), 2401-2406. [More Information]
  • Hunt, N., Mitchell, A., Hee, L., Xu, Y., Ho, Y., McQuillan, J., Sanchez-Perez, A., Miu, J., Weiser, S., Austin, C., Grau, G., Combes, V., Jambou, R., Ball, H. (2008). Early interactions between malaria-infected erythrocytes and the innate immune system determine the course of immune and immunopathological outcomes. International Journal for Parasitology, 38(Suppl 1), S23-S24. [More Information]
  • Wu, L., Zhang, W., Niu, J., Ye, L., Yang, Z., Grau, G., Lou, J. (2008). Phenotypic and functional differences between human liver cancer endothelial cells and liver sinusoidal endothelial cells. Journal of Vascular Research, 45(1), 78-86. [More Information]
  • Penet, M., Abou-Hamdan, M., Coltel, N., Cornille, E., Grau, G., de Reggi, M., Gharib, B. (2008). Protection against cerebral malaria by the low-molecular-weight thiol pantethine. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 105(4), 1321-1326. [More Information]
  • Ramaswamy, Y., Wu, C., Van Hummel, A., Combes, V., Grau, G., Zreiqat, H. (2008). The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic. Biomaterials, 29(33), 4392-4402. [More Information]
  • Bechah, Y., Capo, C., Grau, G., Raoult, D., Mege, J. (2007). A murine model of infection with Rickettsia prowazekii: implications for pathogenesis of epidemic typhus. Microbes and Infection, 9(7), 898-906. [More Information]
  • Delahaye, N., Coltel, N., Puthier, D., Barbier, M., Benech, P., Joly, F., Iraqi, F., Grau, G., Nguyen, C., Rihet, P. (2007). Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice. BMC Genomics, 8(452), 1-16. [More Information]
  • Penet, M., Kober, F., Confort-Gouny, S., Le Fur, Y., Dalmasso, C., Coltel, N., Liprandi, A., Gulian, J., Grau, G., Cozzone, P., et al (2007). Magnetic Resonance Spectroscopy Reveals an Impaired Brain Metabolic Profile in Mice Resistant to Cerebral Malaria Infected with Plasmodium berghei ANKA. Journal of Biological Chemistry, 282(19), 14505-14514. [More Information]
  • Togbe, D., Schofield, L., Grau, G., Schnyder, B., Boissay, V., Charron, S., Rose, S., Beutler, B., Quesniaux, V., Ryffel, B. (2007). Murine cerebral malaria development is independent of Toll-like receptor signaling. The American Journal of Pathology, 170(5), 1640-1648.
  • Niu, J., Zhang, W., Ye, L., Wu, L., Zhu, G., Yang, Z., Grau, G., Lou, J. (2007). The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion. European Journal of Cancer Prevention, 16(6), 517-527.
  • van der Heyde, H., Nolan, J., Combes, V., Gramaglia, I., Grau, G. (2006). A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction. Trends in Parasitology, 22(11), 503-508. [More Information]
  • Meghari, S., Rolain, J., Grau, G., Platt, E., Barrassi, L., Mege, J., Raoult, D. (2006). Antiangiogenic Effect of Erythromycin: An In Vitro Model of Bartonella quintana Infection. The Journal of Infectious Diseases, 193(3), 380-386. [More Information]
  • Hunt, N., Grau, G. (2006). Blood-brain barrier in parasitic disease. International Journal for Parasitology, 36(5), 503-504. [More Information]
  • Coltel, N., Combes, V., Grau, G., Wassmer, S., Chimini, G. (2006). Cell vesiculation and immunopathology: implications in cerebral malaria. Microbes and Infection, 8(8), 2305-2316. [More Information]
  • Combes, V., Coltel, N., Faille, D., Wassmer, S., Grau, G. (2006). Cerebral malaria: role of microparticles and platelets in alterations of the blood-brain barrier. International Journal for Parasitology, 36(5), 541-546. [More Information]
  • Meghari, S., Desnues, B., Capo, C., Grau, G., Raoult, D., Mege, J. (2006). Coxiella burneti stimulates production of RANTES and MCP-1 by mononuclear cells: modulation by adhesion to endothelial cells and its implication in Q fever. European Cytokine Network (Online), 17(4), 253-259.
  • Golenser, J., Waknine, J., Krugliak, M., Hunt, N., Grau, G. (2006). Current perspectives on the mechanism of action of artemisinins. International Journal for Parasitology, 36(14), 1427-1441. [More Information]
  • Peyrefitte, C., Pastorino, B., Grau, G., Lou, J., Tolou, H., Couissinier-Paris, P. (2006). Dengue virus infection of human microvascular endothelial cells from different vascular beds promotes both common and specific functional changes. Journal of Medical Virology, 78(2), 229-242. [More Information]
  • Delahaye, N., Coltel, N., Puthier, D., Flori, L., Houlgate, R., Iraqi, F., Nguyen, C., Grau, G., Rihet, P. (2006). Gene-Expression Profiling Discriminates between Cerebral Malaria (CM)–Susceptible Mice and CM-Resistant Mice. The Journal of Infectious Diseases, 193, 312-321. [More Information]
  • Wassmer, S., Cianciolo, G., Combes, V., Grau, G. (2006). LMP-420, a new therapeutic approach for cerebral malaria? Medecine Sciences, 22(4), 343-345.
  • Zhang, W., Ye, L., Wu, L., Xin, Y., Gu, F., Niu, J., Yang, Z., Zhu, G., Grau, G., Lou, J. (2006). Morphologic, Phenotypic and Functional Characteristics of Endothelial Cells Derived from Human Hepatic Cavernous Hemangioma. Journal of Vascular Research, 43(6), 522-532. [More Information]
  • Schofield, L., Grau, G. (2006). Oversimplification of the role of immunological processes in the pathogenesis of malaria - Author reply. Nature Reviews Immunology, 6(5).
  • Wassmer, S., Combes, V., Candal, F., Juhan-Vague, I., Grau, G. (2006). Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum. Infection and Immunity, 74(1), 645-653. [More Information]
  • Wassmer, S., De Souza, J., Frère, C., Candal, F., Juhan-Vague, I., Grau, G. (2006). TGF-beta1 released from activated platelets can induce TNF-stimulated human brain endothelium apoptosis: a new mechanism for microvascular lesion during cerebral malaria. The Journal of Immunology, 176(2), 1180-1804. [More Information]
  • Combes, V., Coltel, N., Alibert, M., van Eck, M., Raymond, C., Juhan-Vague, I., Grau, G., Chimini, G. (2005). ABCA1 Gene Deletion Protects against Cerebral Malaria: Potential Pathogenic Role of Microparticles in Neuropathology. The American Journal of Pathology, 166(1), 295-302. [More Information]
  • Combes, V., De Souza, J., Rénia, L., Hunt, N., Grau, G. (2005). Cerebral malaria: Which parasite? Which model? Drug Discovery Today: Disease Models, 2(2), 141-147. [More Information]
  • Penet, M., Viola, A., Confort-Gouny, S., Le Fur, Y., Duhamel, G., Kober, F., Ibarrola, D., Izquierdo, M., Coltel, N., Gharib, B., Grau, G., et al (2005). Imaging Experimental Cerebral Malaria In Vivo: Significant Role of Ischemic Brain Edema. The Journal of Neuroscience, 25(32), 7352-7358. [More Information]
  • Schofield, L., Grau, G. (2005). Immunological processes in malaria pathogenesis. Nature Reviews Immunology, 5(9), 722-735. [More Information]
  • Grau, G., Chimini, G. (2005). Immunopathological consequences of the loss of engulfment genes: the case of ABCA1. Societe de Biologie. Journal, 199(3), 199-206. [More Information]
  • Wassmer, S., Cianciolo, G., Combes, V., Grau, G. (2005). Inhibition of Endothelial Activation: A New Way to Treat Cerebral Malaria? PLoS Medicine, 2(9), 885-890. [More Information]
  • Coltel, N., Combes, V., Hunt, N., Grau, G. (2004). Cerebral Malaria - A Neurovascular Pathology with Many Riddles Still to be Solved. Current Neurovascular Research, 1(2), 91-110.
  • Combes, V., Taylor, T., Juhan-Vague, I., Mege, J., Mwenechanya, J., Tembo, M., Grau, G., Molyneux, M. (2004). Circulating Endothelial Microparticles in Malawian Children With Severe Falciparum Malaria Complicated With Coma. JAMA: The Journal of the American Medical Association, 291(21), 2542-2544.
  • Combes, V., Rosenkranz, A., Redard, M., Pizzolato, G., Lepidi, H., Vestweber, D., Mayadas, T., Grau, G. (2004). Pathogenic Role of P-Selectin in Experimental Cerebral Malaria. The American Journal of Pathology, 164(3), 781-786.
  • Wassmer, S., Lepolard, C., Traore, B., Pouvelle, B., Gysin, J., Grau, G. (2004). Platelets Reorient Plasmodium falciparum–Infected Erythrocyte Cytoadhesion to Activated Endothelial Cells. The Journal of Infectious Diseases, 189(2), 180-189.
  • Rogerson, S., Grau, G., Hunt, N. (2004). The Microcirculation In Severe Malaria. Microcirculation, 11(7), 559-576.
  • Hunt, N., Grau, G. (2003). Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria. Trends in Immunology, 24(9), 491-499.
  • Wassmer, S., Coltel, N., Combes, V., Grau, G. (2003). Pathogenesis of cerebral malaria: facts and hypotheses. Medecine Tropicale, 63(3), 254-257.
  • Wassmer, S., Coltel, N., Combes, V., Grau, G. (2003). Pathogenèse du Neuropaludisme: faits et hypothèses. Revista da Sociedade Brasileira de Medicina Tropical (RSBMT), (63), 254-257.
  • Wassmer, S., Combes, V., Grau, G. (2003). Pathophysiology of Cerebral Malaria: Role of host cells in the modulation of cytoadhesion. Annals of the New York Academy of Sciences, 992, 30-38.
  • Grau, G., Mackenzie, C., Carr, R., Redard, M., Pizzolato, G., Allasia, C., Cataldo, C., Taylor, T., Molyneux, M. (2003). Platelet Accumulation in Brain Microvessels in Fatal Pediatric Cerebral Malaria. The Journal of Infectious Diseases, 187(3), 461-466.
  • Lucas, R., Grau, G., Matthay, M., Wendel, A. (2002). Functional dissection of Tumour Necrosis Factor in liver, brain and lungs. Trends in Immunology, (3), 47-59.
  • Dou, L., Cerini, C., Brunet, P., Guilianelli, C., Moal, V., Grau, G., De Smet, R., Vanholder, R., Sampol, J., Berland, Y. (2002). P-cresol, a uremic toxin, decreases endothelial cell response to inflammatory cytokines. Kidney International, 62(6), 1999-2009.
  • Hamacher, J., Lucas, R., Lijnen, H., Buschke, S., Dunant, Y., Wendel, A., Grau, G., Suter, P., Ricou, B. (2002). Tumor necrosis factor-alpha and angiostatin are mediators of endothelial cytotoxicity in bronchoalveolar lavages of patients with acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, 166(5), 651-656.
  • Lucas, R., Montesano, R., Pepper, M., Hafner, M., Sablon, E., Dunant, Y., Grau, G., De Baetselier, P., Mannel, D., Fransen, L. (2001). Lectin-deficient TNF mutants display comparable anti-tumour but reduced pro-metastatic potential as compared to the wild-type molecule. International Journal of Cancer, 91(4), 543-549.
  • Lou, J., Lucas, R., Grau, G. (2001). Pathogenesis of Cerebral Malaria: Recent Experimental Data and Possible Applications for Humans. Clinical Microbiology Reviews, 14(4), 810-820.
  • Stoelcker, B., Hehlgans, T., Weigl, K., Bluethmann, H., Grau, G., Mannel, D. (2001). Requirement for tumour necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria. Infection and Immunity, 70(10), 5857-5859.
  • Harbarth, S., Holeckova, K., Froidevaux, C., Pittet, D., Ricou, B., Grau, G., Vadas, L., Pugin, J. (2001). Usefulness of procalcitonin, interleukin (IL)-6 and IL-8 in critically ill patients admitted with suspected sepsis. American Journal of Respiratory and Critical Care Medicine, 164(3), 396-402.

Conferences

  • Lee, J., Carter, E., Grau, G., Combes, V., Bonhoure, B., Lay, P. (2009). The investigation of monocyte cell signalling by FT-IR spectroscopy. International Conference on Advanced Vibrational Spectroscopy, N/A: N/A.

Patents

  • Hackett, M., Lay, P., Carter, E., Hunt, N., Grau, G., Gottlieb, D. (2010). Classification of biological samples using spectroscopic analysis. Patent No. WO2009AU01423 20091030.

2016

  • O'Regan, N., Gegenbauer, K., O'Sullivan, J., Maleki, S., Brophy, T., Chion, A., Fallon, P., Grau, G., Budde, U., Smith, O., et al (2016). A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria. Blood, 127(9), 1192-1201. [More Information]
  • Sorrell, T., Juillard, P., Djordjevic, J., Kaufman-Francis, K., Dietmann, A., Milonig, A., Combes, V., Grau, G. (2016). Cryptococcal transmigration across a model brain blood-barrier: evidence of the Trojan horse mechanism and differences between Cryptococcus neoformans var grubii strain H99 and C gattii strain R265. Microbes and Infection, 18(1), 57-67. [More Information]
  • Ghadiri, M., Mamlouk, M., Spicer, P., Jarolimek, W., Grau, G., Young, P., Traini, D. (2016). Effect of polyunsaturated fatty acids (PUFAs) on airway epithelial cells' tight junction. Pulmonary Pharmacology and Therapeutics, 40, 30-38. [More Information]
  • Wassmer, S., Grau, G. (2016). Platelets as pathogenetic effectors and killer cells in cerebral malaria. Expert Review of Hematology, 9(6), 515-517. [More Information]
  • Carvalho, T., Morahan, B., John von Freyenda, S., Boeuf, P., Grau, G., Garcia-Bustosa, J., Doerig, C. (2016). The ins and outs of phosphosignalling in Plasmodium: Parasite regulation and host cell manipulation. Molecular and Biochemical Parasitology, 208(1), 2-15. [More Information]

2015

  • Ampawong, S., Chaisri, U., Viriyavejakul, P., Prapansilp, P., Grau, G., Turner, G., Pongponratn, E. (2015). A potential role for interleukin-33 and γ-epithelium sodium channel in the pathogenesis of human malaria associated lung injury. Malaria Journal, 14(1), 1-15. [More Information]
  • Bucur, O., Almasan, A., Zubarev, R., Friedman, M., Nicolson, G., Sumazin, P., Leabu, M., Nikolajczyk, B., Avram, D., Kunej, T., Richardson, D., Grau, G., et al (2015). An updated h-index measures both the primary and total scientific output of a researcher. Discoveries, 3(3), 1-6. [More Information]
  • Kam, A., Li, K., Razmovski-Naumovsk, V., Nammi, S., Chan, K., Grau, G., Li, G. (2015). Curcumin Reduces Tumour Necrosis Factor-Enhanced Annexin V-Positive Microparticle Release in Human Vascular Endothelial Cells. Journal of Pharmacy and Pharmaceutical Sciences, 18(4), 424-433.
  • Hochman, S., Madaline, T., Wassmer, S., Mbale, E., Choi, N., Seydel, K., Whitten, R., Varughese, J., Grau, G., Kamiza, S., et al (2015). Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection. MBIO, 6(5), 1-12. [More Information]
  • Latham, S., Tiberti, N., Gokoolparsadh, N., Holdaway, K., Couraud, P., Grau, G., Combes, V. (2015). Immuno-analysis of microparticles: probing at the limits of detection. Scientific Reports, 5, 1-13. [More Information]
  • Hackett, M., Aitken, J., El Assaad, F., McQuillan, J., Carter, E., Ball, H., Tobin, M., Paterson, D., De Jonge, M., Siegele, R., Grau, G., Hunt, N., Lay, P., et al (2015). Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sites. Science Advances, 6(4), 7-16. [More Information]
  • Cohen, A., Combes, V., Grau, G. (2015). MicroRNAs and Malaria – A Dynamic Interaction Still Incompletely Understood. Journal of Neuroinfectious Diseases, 6(1), 1-12. [More Information]
  • Whittington, C., Grau, G., Murphy, C., Thompson, M. (2015). Unusual angiogenic factor plays a role in lizard pregnancy but is not unique to viviparity. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 324B (2), 152-158. [More Information]
  • Danastas, K., Combes, V., Lindsay, L., Grau, G., Thompson, M., Murphy, C. (2015). VEGF111: New insights in tissue invasion. Frontiers in Physiology, 6, 1-5. [More Information]
  • Grau, G., Thompson, M., Murphy, C. (2015). VEGF: Inflammatory paradoxes. Pathogens and Global Health, 109(6), 253-254. [More Information]

2014

  • Khaw, L., Ball, H., Mitchell, A., Grau, G., Stocker, R., Golenser, J., Hunt, N. (2014). Brain endothelial cells increase the proliferation of Plasmodium falciparum through production of soluble factors. Experimental Parasitology, 145(1), 34-41. [More Information]
  • Jaiswal, R., Grau, G., Bebawy, M. (2014). Cellular communication via microparticles: role in transfer of multidrug resistance in cancer. Future Oncology, 10(4), 655-669. [More Information]
  • Hunt, N., Ball, H., Hansen, A., Khaw, L., Guo, J., Bakmiwewa, S., Mitchell, A., Combes, V., Grau, G. (2014). Cerebral malaria: gamma-interferon redux. Frontiers in Cellular and Infection Microbiology, 4, 1-12. [More Information]
  • Grau, G., Hunt, N. (2014). Cytokines and Some of Their Effector Mechanisms in Cerebral Malaria Pathogenesis. In M. Hommel and P. G. Kremsner (Eds.), Encyclopedia of Malaria, (pp. 1-11). New York: Springer. [More Information]
  • Ampawong, S., Chaisri, U., Viriyavejakul, P., Nontprasert, A., Grau, G., Pongponratn, E. (2014). Electron microscopic features of brain edema in rodent cerebral malaria in relation to glial fibrillary acidic protein expression. International Journal of Clinical and Experimental Pathology, 7(5), 2056-2067.
  • Wheway, J., Latham, S., Combes, V., Grau, G. (2014). Endothelial Microparticles Interact with and Support the Proliferation of T Cells. The Journal of Immunology, 193(7), 3378-3387. [More Information]
  • Wen, B., Combes, V., Bonhoure, A., Weksler, B., Couraud, P., Grau, G. (2014). Endotoxin-Induced Monocytic Microparticles Have Contrasting Effects on Endothelial Inflammatory Responses. PloS One, 9(3), e91597. [More Information]
  • El-Assaad, F., Combes, V., Grau, G., Jambou, R. (2014). Potential Efficacy of Citicoline as Adjunct Therapy in Treatment of Cerebral Malaria. Antimicrobial Agents and Chemotherapy, 58(1), 602-605. [More Information]
  • El Assaad, F., Wheway, J., Hunt, N., Grau, G., Combes, V. (2014). Production, fate and pathogenicity of plasma microparticles in murine cerebral malaria. PLoS Pathogens, 10(3), 1-14. [More Information]
  • Pai, S., Qin, J., Cavanagh, L., Mitchell, A., El-Assaad, F., Jain, R., Combes, V., Hunt, N., Grau, G., Weninger, W. (2014). Real-Time Imaging Reveals the Dynamics of Leukocyte Behaviour during Experimental Cerebral Malaria Pathogenesis. PLoS Pathogens, 10(7), 1-17. [More Information]

2013

  • Jaiswal, R., Luk, F., Dalla, P., Grau, G., Debawy, M. (2013). Breast Cancer-Derived Microparticles Display Tissue Selectivity in the Transfer of Resistance Proteins to Cells. PloS One, 8(4), 1-10. [More Information]
  • Roseblade, A., Luk, F., Rawling, T., Ung, A., Grau, G., Bebawy, M. (2013). Cell-Derived Microparticles: New Targets in the Therapeutic Management of Disease. Journal of Pharmacy and Pharmaceutical Sciences, 16(2), 238-253. [More Information]
  • Latham, S., Chaponnier, C., Dugina, V., Couraud, P., Grau, G., Combes, V. (2013). Cooperation between beta- and gamma-cytoplasmic actins in the mechanical regulation of endothelial microparticle formation. The FASEB Journal, 27(2), 672-683. [More Information]
  • Razakandrainibe, R., Combes, V., Grau, G., Jambou, R. (2013). Crossing the wall: The opening of endothelial cell junctions during infectious diseases. The International Journal of Biochemistry and Cell Biology, 45(7), 1165-1173. [More Information]
  • El-Assaad, F., Wheway, J., Mitchell, A., Lou, J., Hunt, N., Combes, V., Grau, G. (2013). Cytoadherence of Plasmodium berghei-infected red blood cells to murine brain and lung microvascular endothelial cells in vitro. Infection and Immunity, 81(11), 3984-3991. [More Information]
  • Dietmann, A., Millonig, A., Combes, V., Couraud, P., Kachlany, S., Grau, G. (2013). Effects of aggregatibacter actinomycetemcomitans leukotoxin on endothelial cells. Microbial Pathogenesis, 61 - 62, 43-50. [More Information]
  • Khaw, L., Ball, H., Golenser, J., Combes, V., Grau, G., Wheway, J., Mitchell, A., Hunt, N. (2013). Endothelial Cells Potentiate Interferon-γ Production in a Novel Tripartite Culture Model of Human Cerebral Malaria. PloS One, 8(7), 1-13. [More Information]
  • Li, C., Eaton, S., Young, P., Lee, M., Shuttleworth, R., Humphreys, D., Grau, G., Combes, V., Bebawy, M., Gong, J., Buckland, M., et al (2013). Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells. RNA Biology, 10(8), 1333-1344. [More Information]
  • Lee, J., Siegele, R., Pastuovic, Z., Hackett, M., Hunt, N., Grau, G., Cohen, D., Lay, P. (2013). Light and heavy ion beam analysis of thin biological sections. Nuclear Instruments and Methods in Physics Research. Section B, 306, 129-133. [More Information]
  • Gong, J., Luk, F., Jaiswal, R., George, A., Grau, G., Bebawy, M. (2013). Microparticle drug sequestration provides a parallel pathway in the acquisition of cancer drug resistance. European Journal of Pharmacology, 721(1-3), 116-125. [More Information]
  • Walters, S., Kieckbusch, J., Nagalingam, G., Swain, A., Latham, S., Grau, G., Britton, W., Combes, V., Saunders, B. (2013). Microparticles from Mycobacteria-Infected Macrophages Promote Inflammation and Cellular Migration. The Journal of Immunology, 190(2), 669-677. [More Information]
  • Lu, J., Luk, F., Gong, J., Jaiswal, R., Grau, G., Bebawy, M. (2013). Microparticles mediate MRP1 intercellular transfer and the re-templating of intrinsic resistance pathways. Pharmacological Research, 76, 77-83. [More Information]
  • Liu, H., Zhang, W., Jia, Y., Yu, Q., Grau, G., Peng, L., Ran, Y., Yang, Z., Deng, H., Lou, J. (2013). Single-cell clones of liver cancer stem cells have the potential of differentiating into different types of tumor cells. Cell Death and Disease, 4(10), 1-11. [More Information]
  • Wheway, J., Obeid, S., Couraud, P., Combes, V., Grau, G. (2013). The brain microvascular endothelium supports t cell proliferation and has potential for alloantigen presentation. PloS One, 8(1), 1-8. [More Information]

2012

  • Razakandrainibe, R., Pelleau, S., Grau, G., Jambou, R. (2012). Antigen presentation by endothelial cells: what role in the pathophysiology of malaria? Trends in Parasitology, 28(4), 151-160. [More Information]
  • Grau, G., Craig, A. (2012). Cerebral malaria pathogenesis: revisiting parasite and host contributions. Future Microbiology, 7(2), 291-302. [More Information]
  • Faille, D., El Assaad, F., Mitchell, A., Alessi, M., Chimini, G., Fusai, T., Grau, G., Combes, V. (2012). Endocytosis and intracellular processing of platelet microparticles by brain endothelial cells. Journal of Cellular and Molecular Medicine, 16(8), 1731-1738. [More Information]
  • Hackett, M., Lee, J., El Assaad, F., McQuillan, J., Carter, E., Grau, G., Hunt, N., Lay, P. (2012). FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: General implications for disease neurochemistry. ACS Chemical Neuroscience, 3(12), 1017-1024. [More Information]
  • Jaiswal, R., Luk, F., Gong, J., Mathys, J., Grau, G., Bebawy, M. (2012). Microparticle conferred microRNA profiles - implications in the transfer and dominance of cancer traits. Molecular Cancer, 11, 1-13. [More Information]
  • Jaiswal, R., Gong, J., Sambasivam, S., Combes, V., Mathys, J., Davey, R., Grau, G., Bebawy, M. (2012). Microparticle-associated nucleic acids mediate trait dominance in cancer. The FASEB Journal, 26(1), 420-429. [More Information]
  • Gong, J., Jaiswal, R., Mathys, J., Combes, V., Grau, G., Bebawy, M. (2012). Microparticles and their emerging role in cancer multidrug resistance. Cancer Treatment Reviews, 38(3), 226-234. [More Information]
  • Combes, V., Guillemin, G., Chan-Ling, T., Hunt, N., Grau, G. (2012). The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes. Trends in Parasitology, 28(8), 311-319. [More Information]
  • Hafalla, J., Claser, C., Couper, K., Grau, G., Renia, L., De Souza, J., Riley, E. (2012). The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology. PLoS Pathogens, 8(2), 1-12. [More Information]
  • Craig, A., Grau, G., Janse, C., Kazura, J., Milner, D., Barnwell, J., Turner, G., Langhorne, J. (2012). The Role of Animal Models for Research on Severe Malaria. PLoS Pathogens, 8(2), 1-9. [More Information]

2011

  • Hackett, M., McQuillan, J., El Assaad, F., Aitken, J., Levina, A., Cohen, D., Siegele, R., Carter, E., Grau, G., Hunt, N., Lay, P. (2011). Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis. The Analyst, 136(14), 2941-2952. [More Information]
  • Nantakomol, D., Dondorp, A., Krudsood, S., Udomsangpetch, R., Pattanapanyasat, K., Combes, V., Grau, G., White, N., Viriyavejakul, P., Day, N., et al (2011). Circulating red cell-derived microparticles in human malaria. The Journal of Infectious Diseases, 203(5), 700-706. [More Information]
  • Hempel, C., Combes, V., Hunt, N., Kurtzhals, J., Grau, G. (2011). CNS Hypoxia Is More Pronounced in Murine Cerebral than Noncerebral Malaria and is Reversed by Erythropoietin. The American Journal of Pathology, 179(4), 1939-1950. [More Information]
  • McQuillan, J., Mitchell, A., Ho, Y., Combes, V., Ball, H., Golenser, J., Grau, G., Hunt, N. (2011). Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria. International Journal for Parasitology, 41(2), 155-163. [More Information]
  • El Assaad, F., Hempel, C., Combes, V., Mitchell, A., Ball, H., Kurtzhals, J., Hunt, N., Mathys, J., Grau, G. (2011). Differential MicroRNA Expression in Experimental Cerebral and Noncerebral Malaria. Infection and Immunity, 79(6), 2379-2384. [More Information]
  • Combes, V., El-Assaad, F., Grau, G. (2011). Immunopathology and pathophysiology of cerebral malaria. In Mauro Bendinelli, Herman Friedman and Andreas Seyfang (Eds.), Infectious Agents and Pathogenesis. tba: Springer Publishing Company.
  • Saggu, R., Faille, D., Grau, G., Cozzone, P., Viola, A. (2011). In the eye of experimental cerebral malaria. The American Journal of Pathology, 179(3), 1104-1109. [More Information]
  • Jambou, R., El Assaad, F., Combes, V., Grau, G. (2011). In vitro culture of Plasmodium berghei-ANKA maintains infectivity of mouse erythrocytes inducing cerebral malaria. Malaria Journal, 10(1), A346-1-A346-5. [More Information]
  • Hackett, M., Siegele, R., El Assaad, F., McQuillan, J., Aitken, J., Carter, E., Grau, G., Hunt, N., Cohen, D., Lay, P. (2011). Investigation of the mouse cerebellum using STIM and μ-PIXE spectrometric and FTIR spectroscopic mapping and imaging. Nuclear Instruments and Methods in Physics Research. Section B, 269(20), 2260-2263. [More Information]
  • Moxon, C., Grau, G., Craig, A. (2011). Malaria: modification of the red blood cell and consequences in the human host. British Journal of Haematology, 154(6), 670-679. [More Information]
  • Ling, Z., Combes, V., Grau, G., King, N. (2011). Microparticles as immune regulators in infectious disease - an opinion. Frontiers in Immunology, 2(67), 1-8. [More Information]
  • Barbier, M., Faille, D., Loriod, B., Textoris, J., Camus, C., Puthier, D., Flori, L., Wassmer, S., Victorero, G., Alessi, M., Grau, G., et al (2011). Platelets alter gene expression profile in human brain endothelial cells in an in vitro model of cerebral malaria. PloS One, 6(5), e19651-1-e19651-14. [More Information]
  • Ampawong, S., Combes, V., Hunt, N., Radford, J., Chan-Ling, T., Pongponratn, E., Grau, G. (2011). Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. International Journal of Clinical and Experimental Pathology, 4(6), 566-574. [More Information]
  • Hee, L., Dinudom, A., Mitchell, A., Grau, G., Cook, D., Hunt, N., Ball, H. (2011). Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice. International Journal for Parasitology, 41(1), 81-88. [More Information]
  • Wassmer, S., Moxon, C., Taylor, T., Grau, G., Molyneux, M., Craig, A. (2011). Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF. Cellular Microbiology Online, 13(2), 198-209. [More Information]

2010

  • Pankoui Mfonkeu, J., Gouado, I., Fotso Kuate, H., Zambou, O., Combes, V., Grau, G., Amvam Zollo, P. (2010). Biochemical markers of nutritional status and childhood malaria severity in Cameroon. British Journal of Nutrition, 104(6), 886-892. [More Information]
  • Hackett, M., Lay, P., Carter, E., Hunt, N., Grau, G., Gottlieb, D. (2010). Classification of biological samples using spectroscopic analysis. Patent No. WO2009AU01423 20091030.
  • Pankoui Mfonkeu, J., Gouado, I., Fotso Kuate, H., Zambou, O., Amvam Zollo, P., Grau, G., Combes, V. (2010). Elevated Cell-Specific Microparticles Are a Biological Marker for Cerebral Dysfunctions in Human Severe Malaria. PloS One, 5(10), e13415 - 1-e13415 - 9. [More Information]
  • Carpintero, R., Gruaz, L., Brandt, K., Scanu, A., Faille, D., Combes, V., Grau, G., Burger, D. (2010). HDL Interfere with the Binding of T Cell Microparticles to Human Monocytes to Inhibit Pro-Inflammatory Cytokine Production. PloS One, 5(7), e11869-1-e11869-8. [More Information]
  • Combes, V., El-Assaad, F., Faille, D., Jambou, R., Hunt, N., Grau, G. (2010). Microvesiculation and cell interactions at the brain-endothelial interface in cerebral malaria pathogenesis. Progress in Neurobiology, 91(2), 140-151. [More Information]
  • Hunt, N., Grau, G., Engwerda, C., Barnum, S., van der Heyde, H., Hansen, D., Schofield, L., Golenser, J. (2010). Murine cerebral malaria: the whole story. Trends in Parasitology, 26(6), 272-4. [More Information]
  • Couper, K., Barnes, T., Hafalla, J., Combes, V., Ryffel, B., Secher, T., Grau, G., Riley, E., De Souza, J. (2010). Parasite-Derived Plasma Microparticles Contribute Significantly to Malaria Infection-Induced Inflammation through Potent Macrophage Stimulation. PLoS Pathogens, 6(1), e1000744-1-e1000744-13. [More Information]
  • Jambou, R., Combes, V., Mege-Jambou, M., Weksler, B., Couraud, P., Grau, G. (2010). Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions. PLoS Pathogens, 6(7), 1-13. [More Information]
  • Bridges, D., Bunn, J., Van Mourik, J., Grau, G., Preston, R., Molyneux, M., Combes, V., O'Donnell, J., De Laat, B., Craig, A. (2010). Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings. Blood, 115(7), 1472-1474. [More Information]
  • Mitchell, A., Pradel, L., Chasson, L., Van Rooijen, N., Grau, G., Hunt, N., Chimini, G. (2010). Technical Advance: Autofluorescence as a tool for myeloid cell analysis. Journal of Leukocyte Biology, 88(3), 597-603. [More Information]

2009

  • Zhang, W., Wu, L., Liu, H., Ye, L., Xin, Y., Grau, G., Lou, J. (2009). Abnormal blood vessels formed by human liver cavernous hemangioma endothelial cells in nude mice are suitable for drug evaluation. Microvascular research, 78(3), 379-385. [More Information]
  • El-Assaad, F., Combes, V., Grau, G. (2009). Citicoline (CDP-choline): What role in the treatment of complications of infectious diseases. The International Journal of Biochemistry and Cell Biology, 41(7), 1467-1470. [More Information]
  • Bruzzone, R., Dubois-Dalcq, M., Grau, G., Griffin, D., Kristensson, K. (2009). Infectious diseases of the nervous system and their impact in developing countries. P L o S Pathogens, 5(2), e1000199. [More Information]
  • Bebawy, M., Combes, V., Lee, E., Jaiswal, R., Gong, J., Bonhoure, A., Grau, G. (2009). Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells. Leukemia, 23(9), 1643-1649. [More Information]
  • Gouado, I., Pankoui Mfonkeu, J., Fotso, H., Zambou, O., Nguele, S., Combes, V., Grau, G., Amvam Zollo, P. (2009). Physiopathologic factors resulting in poor outcome in childhood severe malaria in Cameroon. The Pediatric Infectious Disease Journal, 28(12), 1081-1084. [More Information]
  • Faille, D., Combes, V., Mitchell, A., Fontaine, A., Juhan-Vague, I., Alessi, M., Chimini, G., Fusai, T., Grau, G. (2009). Platelet microparticles: a new player in malaria parasite cytoadherence to human brain endothelium. The F A S E B Journal, 23(10), 3449-3458. [More Information]
  • Faille, D., El Assaad, F., Alessi, M., Fusai, T., Combes, V., Grau, G. (2009). Platelet-endothelial cell interactions in cerebral malaria: The end of a cordial understanding. Thrombosis and Haemostasis, 102(6), 1093-1102. [More Information]
  • Bechah, Y., Capo, C., Grau, G., Raoult, D., Mege, J. (2009). Rickettsia prowazekii infection of endothelial cells increases leukocyte adhesion through alpha (v)beta(3) integrin engagement. Clinical Microbiology and Infection, 15(Suppl 2), 249-250. [More Information]
  • Larkin, D., de Laat, M., Jenkins, P., Bunn, J., Craig, A., Terraube, V., Preston, R., Donkor, C., Grau, G., Van Mourik, J., et al (2009). Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition. PLoS Pathogens, 5(3), 1-8. [More Information]
  • Lee, J., Carter, E., Grau, G., Combes, V., Bonhoure, B., Lay, P. (2009). The investigation of monocyte cell signalling by FT-IR spectroscopy. International Conference on Advanced Vibrational Spectroscopy, N/A: N/A.

2008

  • von zur Muhlen, C., Sibson, N., Peter, K., Campbell, S., Wilainam, P., Grau, G., Bode, C., Choudhury, R., Anthony, D. (2008). A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI. Journal of Clinical Investigation, 118(3), 1198-1207. [More Information]
  • Togbe, D., de Sousa, P., Fauconnier, M., Boissay, V., Fick, L., Scheu, S., Pfeffer, K., Menard, R., Grau, G., Doan, B., Hansen, A., Ball, H., Hunt, N., et al (2008). Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria. PloS One, 3(7), e2608-1-e2608-12. [More Information]
  • Pankoui Mfonkeu, J., Gouado, I., Fotso Kuate, H., Zambou, O., Grau, G., Combes, V., Amvam Zollo, P. (2008). Clinical presentation, haematological indices and management of children with severe and uncomplicated malaria in Douala, Cameroon. Pakistan Journal of Biological Sciences, 11(20), 2401-2406. [More Information]
  • Hunt, N., Mitchell, A., Hee, L., Xu, Y., Ho, Y., McQuillan, J., Sanchez-Perez, A., Miu, J., Weiser, S., Austin, C., Grau, G., Combes, V., Jambou, R., Ball, H. (2008). Early interactions between malaria-infected erythrocytes and the innate immune system determine the course of immune and immunopathological outcomes. International Journal for Parasitology, 38(Suppl 1), S23-S24. [More Information]
  • Wu, L., Zhang, W., Niu, J., Ye, L., Yang, Z., Grau, G., Lou, J. (2008). Phenotypic and functional differences between human liver cancer endothelial cells and liver sinusoidal endothelial cells. Journal of Vascular Research, 45(1), 78-86. [More Information]
  • Penet, M., Abou-Hamdan, M., Coltel, N., Cornille, E., Grau, G., de Reggi, M., Gharib, B. (2008). Protection against cerebral malaria by the low-molecular-weight thiol pantethine. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 105(4), 1321-1326. [More Information]
  • Ramaswamy, Y., Wu, C., Van Hummel, A., Combes, V., Grau, G., Zreiqat, H. (2008). The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic. Biomaterials, 29(33), 4392-4402. [More Information]

2007

  • Bechah, Y., Capo, C., Grau, G., Raoult, D., Mege, J. (2007). A murine model of infection with Rickettsia prowazekii: implications for pathogenesis of epidemic typhus. Microbes and Infection, 9(7), 898-906. [More Information]
  • Delahaye, N., Coltel, N., Puthier, D., Barbier, M., Benech, P., Joly, F., Iraqi, F., Grau, G., Nguyen, C., Rihet, P. (2007). Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice. BMC Genomics, 8(452), 1-16. [More Information]
  • Penet, M., Kober, F., Confort-Gouny, S., Le Fur, Y., Dalmasso, C., Coltel, N., Liprandi, A., Gulian, J., Grau, G., Cozzone, P., et al (2007). Magnetic Resonance Spectroscopy Reveals an Impaired Brain Metabolic Profile in Mice Resistant to Cerebral Malaria Infected with Plasmodium berghei ANKA. Journal of Biological Chemistry, 282(19), 14505-14514. [More Information]
  • Combes, V., Grau, G. (2007). Microvascular endothelium and cerebral malaria. In William Aird (Eds.), The Endothelium: A Comprehensive Reference. CRC Press.
  • Togbe, D., Schofield, L., Grau, G., Schnyder, B., Boissay, V., Charron, S., Rose, S., Beutler, B., Quesniaux, V., Ryffel, B. (2007). Murine cerebral malaria development is independent of Toll-like receptor signaling. The American Journal of Pathology, 170(5), 1640-1648.
  • Combes, V., Lou, J., Grau, G. (2007). The endothelium in cerebral malaria - Both a target cell and a major player. In William Aird (Eds.), Endothelial Biomedicine, (pp. 1303-1310). United States: Cambridge University Press.
  • Niu, J., Zhang, W., Ye, L., Wu, L., Zhu, G., Yang, Z., Grau, G., Lou, J. (2007). The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion. European Journal of Cancer Prevention, 16(6), 517-527.

2006

  • van der Heyde, H., Nolan, J., Combes, V., Gramaglia, I., Grau, G. (2006). A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction. Trends in Parasitology, 22(11), 503-508. [More Information]
  • Meghari, S., Rolain, J., Grau, G., Platt, E., Barrassi, L., Mege, J., Raoult, D. (2006). Antiangiogenic Effect of Erythromycin: An In Vitro Model of Bartonella quintana Infection. The Journal of Infectious Diseases, 193(3), 380-386. [More Information]
  • Hunt, N., Grau, G. (2006). Blood-brain barrier in parasitic disease. International Journal for Parasitology, 36(5), 503-504. [More Information]
  • Coltel, N., Combes, V., Grau, G., Wassmer, S., Chimini, G. (2006). Cell vesiculation and immunopathology: implications in cerebral malaria. Microbes and Infection, 8(8), 2305-2316. [More Information]
  • Combes, V., Coltel, N., Faille, D., Wassmer, S., Grau, G. (2006). Cerebral malaria: role of microparticles and platelets in alterations of the blood-brain barrier. International Journal for Parasitology, 36(5), 541-546. [More Information]
  • Meghari, S., Desnues, B., Capo, C., Grau, G., Raoult, D., Mege, J. (2006). Coxiella burneti stimulates production of RANTES and MCP-1 by mononuclear cells: modulation by adhesion to endothelial cells and its implication in Q fever. European Cytokine Network (Online), 17(4), 253-259.
  • Golenser, J., Waknine, J., Krugliak, M., Hunt, N., Grau, G. (2006). Current perspectives on the mechanism of action of artemisinins. International Journal for Parasitology, 36(14), 1427-1441. [More Information]
  • Combes, V., Grau, G. (2006). Cytokines in defence and pathology of the central nervous system. In Richard M. Ransohoff, Etty N. Benveniste (Eds.), Cytokines and the CNS - 2nd Edition, (pp. 243-268). United States: CRC Press.
  • Peyrefitte, C., Pastorino, B., Grau, G., Lou, J., Tolou, H., Couissinier-Paris, P. (2006). Dengue virus infection of human microvascular endothelial cells from different vascular beds promotes both common and specific functional changes. Journal of Medical Virology, 78(2), 229-242. [More Information]
  • Delahaye, N., Coltel, N., Puthier, D., Flori, L., Houlgate, R., Iraqi, F., Nguyen, C., Grau, G., Rihet, P. (2006). Gene-Expression Profiling Discriminates between Cerebral Malaria (CM)–Susceptible Mice and CM-Resistant Mice. The Journal of Infectious Diseases, 193, 312-321. [More Information]
  • Wassmer, S., Cianciolo, G., Combes, V., Grau, G. (2006). LMP-420, a new therapeutic approach for cerebral malaria? Medecine Sciences, 22(4), 343-345.
  • Zhang, W., Ye, L., Wu, L., Xin, Y., Gu, F., Niu, J., Yang, Z., Zhu, G., Grau, G., Lou, J. (2006). Morphologic, Phenotypic and Functional Characteristics of Endothelial Cells Derived from Human Hepatic Cavernous Hemangioma. Journal of Vascular Research, 43(6), 522-532. [More Information]
  • Schofield, L., Grau, G. (2006). Oversimplification of the role of immunological processes in the pathogenesis of malaria - Author reply. Nature Reviews Immunology, 6(5).
  • Wassmer, S., Combes, V., Candal, F., Juhan-Vague, I., Grau, G. (2006). Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum. Infection and Immunity, 74(1), 645-653. [More Information]
  • Wassmer, S., De Souza, J., Frère, C., Candal, F., Juhan-Vague, I., Grau, G. (2006). TGF-beta1 released from activated platelets can induce TNF-stimulated human brain endothelium apoptosis: a new mechanism for microvascular lesion during cerebral malaria. The Journal of Immunology, 176(2), 1180-1804. [More Information]

2005

  • Combes, V., Coltel, N., Alibert, M., van Eck, M., Raymond, C., Juhan-Vague, I., Grau, G., Chimini, G. (2005). ABCA1 Gene Deletion Protects against Cerebral Malaria: Potential Pathogenic Role of Microparticles in Neuropathology. The American Journal of Pathology, 166(1), 295-302. [More Information]
  • Combes, V., De Souza, J., Rénia, L., Hunt, N., Grau, G. (2005). Cerebral malaria: Which parasite? Which model? Drug Discovery Today: Disease Models, 2(2), 141-147. [More Information]
  • Penet, M., Viola, A., Confort-Gouny, S., Le Fur, Y., Duhamel, G., Kober, F., Ibarrola, D., Izquierdo, M., Coltel, N., Gharib, B., Grau, G., et al (2005). Imaging Experimental Cerebral Malaria In Vivo: Significant Role of Ischemic Brain Edema. The Journal of Neuroscience, 25(32), 7352-7358. [More Information]
  • Schofield, L., Grau, G. (2005). Immunological processes in malaria pathogenesis. Nature Reviews Immunology, 5(9), 722-735. [More Information]
  • Grau, G., Chimini, G. (2005). Immunopathological consequences of the loss of engulfment genes: the case of ABCA1. Societe de Biologie. Journal, 199(3), 199-206. [More Information]
  • Wassmer, S., Cianciolo, G., Combes, V., Grau, G. (2005). Inhibition of Endothelial Activation: A New Way to Treat Cerebral Malaria? PLoS Medicine, 2(9), 885-890. [More Information]

2004

  • Coltel, N., Combes, V., Hunt, N., Grau, G. (2004). Cerebral Malaria - A Neurovascular Pathology with Many Riddles Still to be Solved. Current Neurovascular Research, 1(2), 91-110.
  • Combes, V., Taylor, T., Juhan-Vague, I., Mege, J., Mwenechanya, J., Tembo, M., Grau, G., Molyneux, M. (2004). Circulating Endothelial Microparticles in Malawian Children With Severe Falciparum Malaria Complicated With Coma. JAMA: The Journal of the American Medical Association, 291(21), 2542-2544.
  • Combes, V., Rosenkranz, A., Redard, M., Pizzolato, G., Lepidi, H., Vestweber, D., Mayadas, T., Grau, G. (2004). Pathogenic Role of P-Selectin in Experimental Cerebral Malaria. The American Journal of Pathology, 164(3), 781-786.
  • Wassmer, S., Lepolard, C., Traore, B., Pouvelle, B., Gysin, J., Grau, G. (2004). Platelets Reorient Plasmodium falciparum–Infected Erythrocyte Cytoadhesion to Activated Endothelial Cells. The Journal of Infectious Diseases, 189(2), 180-189.
  • Rogerson, S., Grau, G., Hunt, N. (2004). The Microcirculation In Severe Malaria. Microcirculation, 11(7), 559-576.

2003

  • Hunt, N., Grau, G. (2003). Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria. Trends in Immunology, 24(9), 491-499.
  • Wassmer, S., Coltel, N., Combes, V., Grau, G. (2003). Pathogenesis of cerebral malaria: facts and hypotheses. Medecine Tropicale, 63(3), 254-257.
  • Wassmer, S., Coltel, N., Combes, V., Grau, G. (2003). Pathogenèse du Neuropaludisme: faits et hypothèses. Revista da Sociedade Brasileira de Medicina Tropical (RSBMT), (63), 254-257.
  • Wassmer, S., Combes, V., Grau, G. (2003). Pathophysiology of Cerebral Malaria: Role of host cells in the modulation of cytoadhesion. Annals of the New York Academy of Sciences, 992, 30-38.
  • Grau, G., Mackenzie, C., Carr, R., Redard, M., Pizzolato, G., Allasia, C., Cataldo, C., Taylor, T., Molyneux, M. (2003). Platelet Accumulation in Brain Microvessels in Fatal Pediatric Cerebral Malaria. The Journal of Infectious Diseases, 187(3), 461-466.

2002

  • Lucas, R., Grau, G., Matthay, M., Wendel, A. (2002). Functional dissection of Tumour Necrosis Factor in liver, brain and lungs. Trends in Immunology, (3), 47-59.
  • Dou, L., Cerini, C., Brunet, P., Guilianelli, C., Moal, V., Grau, G., De Smet, R., Vanholder, R., Sampol, J., Berland, Y. (2002). P-cresol, a uremic toxin, decreases endothelial cell response to inflammatory cytokines. Kidney International, 62(6), 1999-2009.
  • Hamacher, J., Lucas, R., Lijnen, H., Buschke, S., Dunant, Y., Wendel, A., Grau, G., Suter, P., Ricou, B. (2002). Tumor necrosis factor-alpha and angiostatin are mediators of endothelial cytotoxicity in bronchoalveolar lavages of patients with acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine, 166(5), 651-656.

2001

  • Lucas, R., Montesano, R., Pepper, M., Hafner, M., Sablon, E., Dunant, Y., Grau, G., De Baetselier, P., Mannel, D., Fransen, L. (2001). Lectin-deficient TNF mutants display comparable anti-tumour but reduced pro-metastatic potential as compared to the wild-type molecule. International Journal of Cancer, 91(4), 543-549.
  • Lou, J., Lucas, R., Grau, G. (2001). Pathogenesis of Cerebral Malaria: Recent Experimental Data and Possible Applications for Humans. Clinical Microbiology Reviews, 14(4), 810-820.
  • Stoelcker, B., Hehlgans, T., Weigl, K., Bluethmann, H., Grau, G., Mannel, D. (2001). Requirement for tumour necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria. Infection and Immunity, 70(10), 5857-5859.
  • Harbarth, S., Holeckova, K., Froidevaux, C., Pittet, D., Ricou, B., Grau, G., Vadas, L., Pugin, J. (2001). Usefulness of procalcitonin, interleukin (IL)-6 and IL-8 in critically ill patients admitted with suspected sepsis. American Journal of Respiratory and Critical Care Medicine, 164(3), 396-402.
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