Professor Georges Grau
Professor of Vascular Immunology
Pathology, School of Medical Sciences
Bosch Institute
Member of China Studies Centre
Member of The University of Sydney Nano Institute
Member of the Charles Perkins Centre
Telephone | +61 2 9036 3260 |
Fax | +61 2 -------------- |
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Website |
Marie Bashir Institute Bosch Institute Sydney Nano Institute |
Curriculum vitae | Curriculum vitae |
Biographical details
2006 - present: Professor, Chair of Vascular Immunology, Department of Pathology, School of Medical Sciences, Faculty of Medicine, University of Sydney
1999 - 2006: Professeur des Universites (Physiologie, section 40), Universite de la Mediterranee 1998 - 1999: Research Associate, CNRS, Prof. D. Raoult, Marseille 1997 - 1998: Invited Professor, Department of Pathology, University of Regensburg 1995 - 1997: Chef de Clinique Scientifique, University of Geneva 1992: Privat - Docent (Agregation de l'Enseignement Superieur), Faculty of Medicine, University of Geneva 1991 - 1995: Maitre de'Enseignement et de Recherche at the WHO Centre and at the Department of Pathology, University of Geneva 1989 - 1991: Charge de Recherche, Departement de Pathologie, University of Geneva 1984 - 1988: Assistant en Medecine Fondamentale, Department of Pathology, University of Geneva 1984: M.D. Thesis, University of Geneva 1983: Candidate-Specialist in Internal Medicine, Universite de Liege 1982 - 1995: Research Associate, World Health Organisation, Immunology Research and Training Centre, Prof. P.H. Lambert, University of Geneva, Switzerland 1981 - 1982: Post-Doctoral Fellow, Institut de Pathologie Cellulaire, Prof. M. Bessis, Hopital du Kremlin-Bicetre, Paris, France 1979 - 1983: Resident, Department of Internal Medicine, Prof. H. van Cauwenberghe, Hopital Universitaire de Baviere, Liege 1972 - 1979: Doctor of Medicine (with High Distinction), University of Liege
Research interests
Immunopathology of microvascular lesions, particularly of cerebral and pulmonary complications of infectious and auto-immune diseases, especially in cerebral malaria, septic shock and multiple sclerosis. Analysis of the cellular and molecular mechanisms of the interactions between microvascular endothelial cells and cells of the immune system. Experience in various in vivo and in vitro experimental systems as well as in clinical studies. More recently, focus on the neurovascular lesion of murine and human cerebral malaria, using co-culture model systems involving brain endothelium, P. falciparum infected erythrocytes, as well as circulating cells, particularly platelets and monocytes.
Additional keywords: endothelium; cytokines; platelets; microparticles; brain diseases; cerebral malaria; sepsis; septic shock
Honours project opportunities
- The role of microparticles in the immune response to WNV
- Extracellular vesicles in the pathogenesis of infectious diseases
- Monocyte subset characterisation in brain complications of infectious diseases
- Monocyte subset characterisation in brain complications of infectious diseases
- Defining the antigen presentation capacity of endothelial cells and their microparticles
- Investigating the roles of extracellular vesicles (EV) in cancer
Selected grants
2019
- SpectraMax iD5 Multi-Mode Microplate Reader; Dunstan C, Grau G, Murray M; DVC Research/Equipment Grant.
2018
- Zebrafish models of mycobacterial infection; Oehlers S, Grau G; DVC Research/Postdoctoral Research Fellowship Scheme.
- Bioinorganic Chemistry of Chemical Warfare of Immune Cells with Pathogens; Lay P, Grau G; Australian Research Council (ARC)/Discovery Projects (DP).
- Understanding the induction of disease quiescence by immunomodulating drug in multiple sclerosis; Hodgkinson S, Grau G, Hawke S, Byrne S, Zinger A, Barnett M; Multiple Sclerosis Research Australia/Project Grant.
- Sydney Nano Research Collaboration Award; Grau G; Australian Institute of Nanoscience and Technology (AINST)/Research Collaboration Award.
2017
- RES: Groups 5-10 CBA Mice are to be infected with the Pba strain of malaria- with Cour Pharma; King N, Grau G, Niewold P, Cohen A; COUR Pharmaceuticals Development Co. INC/Client Commissioned Research.
2016
- Understanding the role of B lymphocytes and microparticles in multiple sclerosis (MS); Grau G; Sydney Medical School Foundation/Foundation Grant.
- AINST - Flagship Program MS; Grau G; Australian Institute of Nanoscience and Technology (AINST)/Flagship Program.
- Antigen Presentation In Cerebral Malaria Pathogenesis: A Role For Brain Microvascular Endothelium And Microparticles; Grau G, Combes V, Hunt N, Saunders B; National Health and Medical Research Council (NHMRC)/Project Grants.
- Real time bio-impedance measurement of biological samples: Electrical Cell-substrate Impedance Spectroscopy ECIS Zθ equipped with Ibidi Pump System; Traini D, Young P, Zreiqat H, Grau G, Ammit A; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Advanced NanoSight NS300 System; Halliday G, Richardson D, Chan H, Grau G, Shackel N; University of Sydney/Equipment Grant.
2015
- Characterising splenic myeloid responses to CNS pathogens; Mitchell A, Grau G, Fazekas de St Groth B, King N, Palendira U; University of Sydney/Internal Scheme.
- Portable Infrared Spectroscopy Equipment for Cancer Diagnosis, Research into Prevention of Cancer by Understanding the Role of Diet, and for Drug Development and Studies on Efficacy; Lay P, Richardson D, Banati R, Biro M, Bebawy M, Graeber M, Grau G, Hambley T, New E, Carter E; Cancer Institute NSW/Equipment Grant.
- Trans-endothelial migration of leucocytes of Multiple Sclerosis (MS) patients across an in vitro blood-brain barrier model; Hawke S, Zinger A, Grau G; Medical Advances Without Animals/Research Grants.
- CJDSGN Memorial Awards for research in CJD related diseases; Grau G, Hawke S; CJD Support Group Network/Donation.
- Developing and testing pro-thrombotic conjugates for brain AVMs; Grau G; National Health and Medical Research Council (NHMRC)/Project Grants.
- Live Cell Accessories for Raman and FTIR Imaging; Lay P, Hawkins C, Grau G, Witting P, Chan H; DVC Research/Equipment Grant.
2014
- Characterizing plasma microparticle content in multiple sclerosis patients; Wheway J, Zinger A, Hawke S, Grau G, Combes V; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
2013
- Deciphering the role of microparticles from discrete origins in the pathogenesis of cerebral malaria using a novel in vitro system to replace animal models.; Grau G, Combes V; Medical Advances Without Animals/Research Grants.
- Wide field super-resolution microscopy with ground state depletion - Exploring nanoscopic life in chronic diseases; Braet F, Weiss A, King N, Dos Remedios C, Traini D, Graeber M, Murphy C, Grau G, Soon L, Newsome T, Goldsbury C, Lovelace M, Gorrell M, Pollock C; DVC Research/Equipment Grant.
2012
- The link between the angiogenesis of live birth and cancer: a lizard model; Thompson M, Murphy C, Grau G; Australian Research Council (ARC)/Discovery Projects (DP).
- Australia-Thai Symposium - Infectious diseases and immunology: translating research into practice; Grau G, Campbell D, Freckelton L, Kakakios A, Kulthanan T, Tribuddharat C; Office of Global Engagement/IPDF Grant.
- BD Influx 3-L Cell Sorter; Britton W, King N, Grau G, Weninger W, McCaughan G, Slobedman B, Saunders B, West N, Triccas J, Abendroth A, Combes V, Bowen D, Shackel N, Ellis M; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Microparticles are pathogenic elements in the pathophysiology of cerebral malaria; Combes V, Grau G, Wheway J; National Health and Medical Research Council (NHMRC)/Project Grants.
- The astrocyte: a crossroads in cerebral malaria pathogenesis; Hunt N, Ball H, Grau G; National Health and Medical Research Council (NHMRC)/Project Grants.
- Microparticles and Cellular Signalling During Tuberculosis Infection; Saunders B, Britton W, Grau G, Combes V; DVC Research/Bridging Support Grant.
2011
- The involvement of the kynurenine pathway in blood brain barrier disruption and its relevance for neuroinflammatory diseases; Guillemin G, Combes V, Grau G, Brew B; National Health and Medical Research Council (NHMRC)/Project Grants.
- Fluorescence microscopy with optical tweezers: imaging cellular responses; Weninger W, Gunning P, Grau G, King N, Grewal T, Soon L; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
- Microparticles and Selective Trait Dominance in Multidrug Resistant Cancers; Bebawy M, Grau G, Combes V; National Health and Medical Research Council (NHMRC)/Project Grants.
- DEEP SEQUENCING OF GLIOMA DERIVED MICROP ARTICLES; Grau G, Suter C; Cancer Council New South Wales/Innovator Grant.
- Microparticles and Selective Trait Dominance in Multidrug Resistant Cancers; Bebawy M, Grau G, Combes V; National Health and Medical Research Council (NHMRC)/Project Grants.
- Endothelial cells and their microparticles as immunomodulators in cerebral malaria; Wheway J, Grau G; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
2010
- Deciphering molecular mechanisms of endothelial vesiculation; Grau G; DVC Research/Bridging Support Grant.
- A 5-D Correlative Imaging Platform: Combining the Strengths of Light and Electron Microscopy; Braet F, Mitchell H, Soon L, Overall R, Day D, Waterhouse P, Marc J, Conigrave A, Weiss A, Newsome T, Meikle S, Goetz J, Goldsbury C, Hambley T, Ramzan I, Young P, Traini D, Grewal T, Fleming S, Murphy C, Grau G, Weninger W, Dos Remedios C, Wimmer-Kleikamp S, Munroe P, Stevens-Kalceff M, Foster L, Killingsworth M; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
- Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
2009
- Panthetine, a Putative Treatment for Cerebral Malaria; Sanchez-Perez A, Grau G; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
- Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas de St Groth B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- 7-laser BD LSR-II and Cellomics Array Scan VTi to Enhance Capability and Throughput for the NSW Advanced Cytometry Facility; King N, Weninger W, Gunning P, Fazekas de St Groth B, Campbell I, Christopherson R, Black J, Mason R, Richardson D, Halliday G, Grau G, Gandevia S, Kachigian L, Geczy C, Jessup W, Vadas M, Britton W, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
- StreamLineTM Plus- Rapid Chemical Mapping; Lay P, Grau G, Richardson D, Hambley T, Witting P, Carter E; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Pathophysiological alterations of brain microvascular endothelial cells in cerebral malaria; Grau G, Sanchez-Perez A, Combes V; National Health and Medical Research Council (NHMRC)/Project Grants.
- Cytokine and macrophage determinants of pulmonary inflammation during tuberculosis; Saunders B, Britton W, Grau G; National Health and Medical Research Council (NHMRC)/Project Grants.
- Novel coatings for orthopaedic implants; Grau G, Little D, Zreiqat H, Dunstan C; National Health and Medical Research Council (NHMRC)/Project Grants.
- Microparticle Mediated Transfer of P-glycoprotein in Conferring Multidrug Resistance in Cancer; Bebawy M, Grau G, Combes V; Cancer Council New South Wales/Research Project Grants.
2008
- Dako ACIS 111 Cellular Image Acquisition and Analysis System; Hambly B, Bao B, Bishop A, Black J, Campbell I, Dong Q, Gorrell M, Grau G, Hunt N, King N, Markham R, Marsh D, McDonald K, McLennan S, Rodgers K, Seth D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
- Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological Materials, and Medical Research; Bernard C, Marshall C, Wood B, Potts D, Penny D, Dutkiewicz A, Grau G, Sorrell T, Swain M, Yang W, Soon L, Lay P, McNaughton D, Maschmeyer T, Ramzan I, Beardall J, Traini D, Carter E; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
- Dysregulation of cytokine networks: a key determinant of the pathogenesis of cerebral malaria; Hunt N, Ball H, Grau G; National Health and Medical Research Council (NHMRC)/Project Grants.
- Integrated Vibrational Spectroscopic Mapping for Archeological, Biological, Geological, Materials and Medical Research; Lay P, McNaughton D, Maschmeyer T, Potts D, Swain M, Grau G, Sorrell T, Ramzan I, Beardall J, Bernard C, Marshall C, Dutkiewicz A, Penny D, Wood B, Yang W, Soon L, Traini D, Carter E; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
- Dako ACIS III Cellular Image Acquisition and Analysis System; Gorrell M, Grau G, Bishop A, Black J, Campbell I, McLennan S, Rodgers K, Seth D, Marsh D, Dong Q, Hambly B, Bao B, King N, Markham R, McDonald K, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
- Pathogenic Roles of Microparticles in Cerebal Malaria; Grau G; National Health and Medical Research Council (NHMRC)/Project Grants.
2007
- PHERSAstar and POLARstar optima multifunctional plate readers with robotic high throughout screening system for multi-disciplinary cancer research; Grau G, Hunt N, Richardson D; Cancer Institute NSW/Research Grant.
- Odyssey Infrared imaging system; Grau G, Sorrell T; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- Cell AnalySYS Facility Platform, Epic XL MCL Flow Cytometer FC-500, AutoMACS magnetic cell sorter and Geminin EM spectrofluorometer; Grau G; University of Sydney/Major Equipment Grant.
- PHERAstar and POLARstar Optima multi-functional plate readers with robotic high throughput screening system for multi-disciplinary cancer research; Halliday G, Ho P, Conigrave A, Iland H, Lee C, Joshua D, Cook D, Richardson D, Reichardt J, Grau G, Lovejoy D, Hunt N, King N, Mason R, Murphy C, Sharland A, Assinder S, Dong Q, Bishop A; Cancer Institute NSW/Infrastructure Grant.
- Microparticles as effectors of microvascular alterations in brain inflammation; Grau G, Hunt N; Australian Research Council (ARC)/Discovery Projects (DP).
- Total internal reflectance fluorescence microscope (TIRFM); Soon L, Rendina L, Braet F, Weiss A, Grau G, Lyons G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- The role of von Willebrand Factor (vWF) in malaria pathogenesis; Grau G, Craig A; Wellcome Trust (UK)/Research Support.
- Pathogenic Role of Microparticles in Cerebral Malaria; Grau G, De Souza J, Burger D, Ryffel B, Renia L, Gouado I, Molyneux M, Combes V, Chimini G; European Commission (Belgium)/Framework Programme FPRx2095 SCHx5247.
- Twister microplate handle: A robotic system for the Bruker HTS-XT infrared module.; Lay P, Hunt N, Grau G, Sorrell T, Witting P; National Health and Medical Research Council (NHMRC)/Equipment Grants.
- MFB cell analysis facility platform, EpicXL MCL flow cytometer, autoMACS magnetic cell sorter and Ge; Grau G; DEST/Major Equipment.
- Relationship between cell-cell interactions and disease severity in patients with cerebral malaria; Grau G, Cook D, Hunt N; National Health and Medical Research Council (NHMRC)/Project Grants.
- Statins, microparticles and cerebral malaria; Grau G; Rebecca L Cooper Medical Research Foundation/Rebecca Cooper Foundation FPRx394 SCHx758.
2006
- University of Sydney - USYD Professorial Research fellowship; Grau G; University of Sydney/Professorial Research fellowship.
- Pathophysiology of malaria-associated lung disease; Hunt N, Ball H, Grau G, Anstey N; National Health and Medical Research Council (NHMRC)/Project Grants.
2005
- Pathophysiology of the micro-vascular lesion during cerebral malaria: Grau. Study of the interactions between endothelium, red blood cells and circulating cells.; Grau G, Buguet B, Fusai T; GENERAL DIRECTION OF ARMY (France)/Research Support.
- Platelets in pathogenesis of cerebral malaria; Grau G, Bunn J, van Rooien J, Craig A; Wellcome Trust (UK)/Research Support.
- Vesiculation and Endothelial Thrombosis: molecular and cellular mechanisms and role in the inter-cellular communication; Grau G; Foundation of France/Research Support.
2004
- TBA; Grau G, Molyneux M, Roberts D; Wellcome Trust (UK)/Research Support.
- TBA; Grau G; FONDATION RECHERCHE MEDICALE/Equipment.
Selected publications
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