Associate Professor Mark Gorrell

Associate Professor
Medicine, Central Clinical School
Centenary Institute of Cancer Medicine & Cell Biology

Telephone +61 2 9565 6152
Fax +61 2 9565 6101

Website Cenenary Institute
Curriculum vitae Curriculum vitae

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Biographical details

Associate Professor Mark Gorrell heads the Molecular Hepatology Laboratory in the Liver Injury and Cancer Program. He trained in cell biology, virology, immunology and protein biochemistry at Australian National University, University of Melbourne and Johns Hopkins University. His research is focussed upon liver cancer prevention and treatment, chronic liver disease pathogenesis, diabetes, protein and enzyme biochemistry and cell biology related to the proteases DPP4, DPP9 and fibroblast activation protein (FAP). He has authored over 130 publications attracting H index 40, i10 index 85 and > 5,400 citations. His research experience also includes small RNA viruses, transcriptomics, proteomics and cell biology. His research was important in the development of DPP4-targetted therapies for type 2 diabetes, which are now used to treat millions of patients. Inside Centenary Institute,he chairs the postgraduate research and equipment grants committees, is Sub-Dean for postgraduate research and a Commercialisation Committee member. Outside Centenary Institute, he is active in the International Proteolysis Society, the Gastroenterological Society of Australia, NHMRC grant reviews, and editorial boards of Journals including Scientific Reports.

Research interests

Mark D. Gorrell is devoted to understanding the functions of the dipeptidyl peptidase IV [DPP4] gene family enzymes and the molecular basis of chronic liver disease and how to exploit this knowledge to alleviate human illness. DPP4 is the target of a successful new type 2 diabetes therapy that is benefiting millions of patients.

With colleagues, he discovered that DPP4 modifies the activities of several chemokines [1997 J Exp Med]. He discovered DPP8, DPP9 and DPP10 (2000 FEBS J; 2004 BBA; 2006 BBA) allowing the development of DPP4 selective inhibitors. His work on DPP4 function in human T cells and on DPP9 provided key insights into the safety of DPP4 inhibitors in clinical use [2011 Scand J Immunol; 2013 PlosOne]. He also discovered novel substrate recognition sites in DPPs used in drug development, ligand binding sites on DPP4 that are binding sites of MERS virus, and constructed the first DPP4 protein structure prediction [1999 FEBS J; 1999 FEBS Lett].

His team showed that DPP4, FAP and DPP9 amplify cell death signals and alter cell adhesion [2006 FEBS J; 2005 Hepatology; 2011 Mol Cancer Res; 2015 BBA-MCR], identified several chemokines cut by DPP8 [2008 FEBS Letters], and identified most of the known substrates of FAP [2011 FEBS J] and DPP9 [2015 FEBS J]. Using novel 2-photon microscopy, showed that harmful collagen is near FAP in cirrhotic liver [2003 J Struct Biol]. He found that the levels of FAP in human blood specifically correspond to the presence of liver fibrosis [2015 Diabetes Research].

He found that mice lacking DPP9 die soon after birth and that these mice have metabolism defects [2013 PlosOne; 2016 Expl Cell Res]. He found that DPP9 influences growth factor signaling [2011 Mol Cancer Res].

Teaching and supervision

I supervise honours and postgraduate reearch students in topics related to those in which I have published.

Current projects

Current projects focus on FAP, DPP4 and DPP9 in liver diseases.

Associations

Current memberships:

· American Society for Virology [life member 2005-] 1990 -.

· Australia & New Zealand Society for Cell and Developmental Biology (ANZSCDBI) 1989 - (Governing Committee member 1994-1998, Treasurer 1994-1996).

· Australian Society for Biochemistry and Molecular Biology (ASBMB) 2002 -.

· Australian Society for Immunology 1980 -.

· Gastroenterological Society of Australia 1996 -. Research Committee member 2013-17.

International Proteolysis Society 2000 -. Treasurer and Governing Council member 2011-2015.

The Sydney Protein Group 1989 -.

Awards and honours

Current awards:

2016 Rebecca L Cooper Medical Research Foundation Ltd Equipment grant 10422. “Developing an improved therapy for type 2 diabetes”. M D Gorrell [supported by Hui Zhang, G W McCaughan, J Gamble, NA Shackel, XJ Zheng, JB Chen, R Liu]

2016 Diabetes Australia Research Trust General Grant. “Preclinical evaluation of a new therapy for type 2 diabetes.”Mark D Gorrell

2016-20 NHMRC Project Grant 1105238. “DPP4 family proteases as driversof chronic liver injury”. A/Pr MD Gorrell, Prof GW McCaughan, Prof S Twigg, Prof WW Bachovchin.

2016-18 NHMRC Project Grant 1099375. “Diabetes drug for ovarian cancer”. A/Pr Magdelina Plebanski, Dr Andrew N Stephens, Prof Martin Oehler, A/Pr MD Gorrell.

2016-17 NHMRC Development Grant 1113842. “A novel liver cancer therapytargeting tumour stroma”. A/Pr MD Gorrell, Prof GW McCaughan.

Keywords

Diabetes; Cell biology; Hepatology; Cancer; Immunology

Clinical Specialty

Gastroenterology and Hepatology

International links

Australia

(Flinders University School of Biological Sciences) research collaboration on dipeptidyl peptidases

Australia

(University of Sydney Endocrinology) research collaboration on DPP4 in diabetes complications

Australia

(University of Sydney Pharmacy Faculty) research collaboration on dipeptidyl peptidases

Germany

(Georg-August-Universität Göttingen) Dr Ruth Geiss-Friedlander: DPP9

Germany

(University of Freiburg) collaborative basic research on FAP

United States

(Tufts University) collaborative research

Selected grants

2016

  • Novel 3D printed scaffolds for intervertebral fusion; Gorrell M; Rebecca Cooper Foundation/Research Grant.
  • A novel liver cancer therapy targeting tumour stroma; Gorrell M, McCaughan G, Brokopp C; National Health and Medical Research Council (NHMRC)/Development Grants.
  • DPP4 family proteases as drivers of chronic liver injury; Gorrell M, McCaughan G, Twigg S, Bachovchin W; National Health and Medical Research Council (NHMRC)/Project Grants.

2015

  • Novel therapy approaches for diabetes and its liver and heart complications; Gorrell M, Keane F, Tu T, Shackel N, Bowen D, Bertolino P, Seth D, Chen J, Cook A, Liu R, Zheng X, Gamble J, McCaughan G; Rebecca L Cooper Medical Research Foundation/Research Support.

2014

  • Protease therapies for diabetes-associated liver disease; Gorrell M, Keane F, Cook A, Shackel N, Seth D, Chen J, Jolly C, Hare N, McCaughan G; Rebecca L Cooper Medical Research Foundation/Equipment Grant.

2013

  • Wide field super-resolution microscopy with ground state depletion - Exploring nanoscopic life in chronic diseases; Braet F, Weiss A, King N, Dos Remedios C, Traini D, Graeber M, Murphy C, Grau G, Soon L, Newsome T, Goldsbury C, Lovelace M, Gorrell M, Pollock C; DVC Research/Equipment Grant.

2012

  • Targeting proteases for a novel therapy for type 2 diabetes and liver complications.; Gorrell M, Twigg S, McLennan S, McCaughan G, Chowdhury S; Diabetes Australia Research Trust (DART)/Research Grants.
  • Novel outcome predictors in HCV post-liver transplant; Gorrell M, McCaughan G; Australian Centre for HIV and Hepatitis Virology Research (ACH2)/HIV and Hepatitis C Virology and Immunology Research Grants.
  • A novel approach to understanding and preventing tumor development; Gorrell M, Schilling O; Group of Eight/Germany Joint Research Co-operation Scheme.

2011

  • automated storage, retrieval, and UV imaging system; Jormakka M, Gamble J, Semsarian C, Rasko J, Vadas M, Xia P, Gorrell M, Clarke R, Holst J, Church W; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • The biological roles of dipeptidyl peptidases; Gorrell M; DVC Research/Bridging Support Grant.

2010

  • Next-generation high-speed flow cytometric cell sorter; Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons G, Sword G; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Diabetes exacerbates non-alcoholic steato-hepatitis (NASH); Twigg S, McLennan S, Gorrell M; National Health and Medical Research Council (NHMRC)/Project Grants.

2009

  • Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility; King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas de St Groth B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Inverted Multiphoton Intravital Microscope; Weninger W, Gorrell M, Halliday G, Jones C, Fazekas de St Groth B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2008

  • Therapeutic potential of the dipeptidyl peptidase IV gene family; Gorrell M; National Health and Medical Research Council (NHMRC)/Project Grants.
  • Dako ACIS III Cellular Image Acquisition and Analysis System; Gorrell M, Grau G, Bishop A, Black J, Campbell I, McLennan S, Rodgers K, Seth D, Marsh D, Dong Q, Hambly B, Bao B, King N, Markham R, McDonald K, Hunt N; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • Dako ACIS 111 Cellular Image Acquisition and Analysis System; Hambly B, Bao B, Bishop A, Black J, Campbell I, Dong Q, Gorrell M, Grau G, Hunt N, King N, Markham R, Marsh D, McDonald K, McLennan S, Rodgers K, Seth D; Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF).
  • a/ BMG Labtech polarstar Omega fluorescence polarization reader with luminescence b/ Dedicated PC; Gorrell M; National Health and Medical Research Council (NHMRC)/Equipment Grants.

2005

  • Cooled gradient palm cycler and rotor-shake genie; Bishop A, Sharland A, Allen R, Gorrell M, Chadban S; National Health and Medical Research Council (NHMRC)/Equipment Grants.
  • Enzyme Inhibition Test for Dipeptidyl Peptidases 8 & 9 (TPL); Tadayyon M, Gorrell M, McCaughan G; Torrent Pharmaceuticals Limited/BLO Project.
  • FACS Aria for the University of Sydney Flow Cytometry Facility; King N, Pollard J, Rasko J, Lovicu F, Bishop A, Bertolino P, Briscoe H, Gillies M, Madigan M, McAvoy J, Murphy C, Balcar V, Armour C, Hughes M, Reeve V, Christopherson R, Halliday G, Christie M, Pollock C, McCaughan G, Gorrell M, Dong Q, Abendroth A, Menzies S, Barnetson R, Byrne S, Hunt N, Hambly B, Cook D, Mason R, Day M, Black J; University of Sydney/Equipment Grant.
  • Role of Dipeptidyl Peptidases in Liver Fibrosis; Ashworth D, Gorrell M; Ferring Research Ltd/Ferring Research Ltd.

2003

  • Nucleic Acid Extraction Facility; Bishop A, McCaughan G, Gorrell M, Halliday G; Rebecca L Cooper Medical Research Foundation/Equipment Grant.
  • Molecular Pathogenesis of alcoholic liver disease; Haber P, Gorrell M, McCaughan G; Hlth & Medical Research Grants/Research Grant.

Selected publications

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Book Chapters

  • Abbott, C., Gorrell, M. (2013). Dipeptidyl Peptidase 8. In Neil D. Rawlings, Guy Salvesen (Eds.), Handbook of Proteolytic Enzymes: Volume 3, (pp. 3379-3384). London, United Kingdom: Elsevier. [More Information]
  • Gorrell, M., Park, J. (2013). Fibroblast Activation Protein alpha. In Neil D. Rawlings, Guy Salvesen (Eds.), Handbook of Proteolytic Enzymes: Volume 3, (pp. 3395-3401). London, United Kingdom: Elsevier. [More Information]
  • Keane, F., Chowdhury, S., Yao, T., Nadvi, N., Gall, M., Chen, Y., Osborne, B., Ribeiro, A., Church, W., McCaughan, G., Gorrell, M., Yu, M. (2012). Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy. In Ben Dunn (Eds.), Proteinases as Drug Targets, (pp. 118-144). Cambridge, UK: RSC Publishing.
  • McCaughan, G., Shackel, N., Williams, R., Seth, D., Haber, P., Gorrell, M. (2007). Genomics, gene arrays and proteomics in the study of liver disease. In Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, and Mario Rizzetto (Eds.), The Textbook of Hepatology: From Basic Science to Clinical Practice, (pp. 398-420). USA: Blackwell Publishers.
  • Gorrell, M., Yu, M. (2005). Diverse functions in a conserved structure: The dipeptidyl peptidase IV gene family. In Robinson J (Eds.), Trends in Protein Research, (pp. 1-78). New York: Nova Biomedical Books.
  • Stockel-Maschek, A., Stiebitz, B., Faust, J., Born, I., Kahne, T., Gorrell, M., Neubert, K. (2003). Different inhibition mechanisms of dipeptidyl peptidaseIV by tryptophan containing peptides and amides. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 69-72). NY: Springer.
  • Chen, T., Ajami, K., McCaughan, G., Gorrell, M., Abbott, C. (2003). Dipeptidyl peptidase IV gene family. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 79-88). NY: Springer.
  • Gorrell, M., Wang, X., Levy, M., Kable, E., Marinos, G., Cox, G., McCaughan, G. (2003). Intrahepatic expression of collagen and fibroblast activation protein (FAP) in hepatitis C virus infection. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 235-243). NY: Springer.
  • Ajami, K., Abbott, C., Gysbers, V., Kaehne, T., McCaughan, G., Gorrell, M. (2003). Molecular chimeras and mutational analysis in the prolyl oligopeptidase gene family. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 49-55). NY: Springer.
  • Abbott, C., Gorrell, M. (2002). The family of CD26/DPIV and related ectopeptidases: the DPIV family. In J Langner, S Ansorge (Eds.), Ectopeptises: CD13/Aminopeptidase N and CD26/Dipeptidylpeptidase IV in Medicine and Biology, (pp. 171-194). New York, USA: Staempfli Publishers Ltd.

Journals

  • Chen, Y., Gall, M., Zhang, H., Keane, F., McCaughan, G., Yu, M., Gorrell, M. (2016). Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes. Experimental Cell Research, 342(1), 72-82. [More Information]
  • Wilson, C., Zhang, H., Gorrell, M., Abbott, C. (2016). Dipeptidyl peptidase 9 substrates and their discovery: Current progress and the application of mass spectrometry-based approaches. Biological Chemistry, 397(9), 837-856. [More Information]
  • Wong, P., Gall, M., Bachovchin, W., McCaughan, G., Keane, F., Gorrell, M. (2016). Neuropeptide Y is a physiological substrate of fibroblast activation protein: Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver cirrhosis and hepatocellular carcinoma. Peptides, 75, 80-95. [More Information]
  • Williams, K., Vieira de Ribeiro, A., Prakoso, E., Veillard, A., Shackel, N., Brooks, B., Bu, Y., Cavanagh, E., Raleigh, J., McLennan, S., McCaughan, G., Keane, F., Gorrell, M., Twigg, S., et al (2015). Circulating Dipeptidyl Peptidase-4 Activity Correlates with Measures of Hepatocyte Apoptosis and Fibrosis in NAFLD in Type 2 Diabetes Mellitus and Obesity: A Dual Cohort Cross-Sectional Study. Journal of Diabetes, 7(6), 809-819. [More Information]
  • Zhang, H., Chen, Y., Wadham, C., McCaughan, G., Keane, F., Gorrell, M. (2015). Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1853 (2), 470-480. [More Information]
  • Zhang, H., Maqsudi, S., Rainczuk, A., Duffield, N., Lawrence, J., Keane, F., Justa-Schuch, D., Geiss-Friedlander, R., Gorrell, M., Stephens, A. (2015). Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis. The FEBS Journal, 282(19), 3737-3757. [More Information]
  • Jayawickrama, G., Sadig, R., Sun, G., Nematollahi, A., Nadvi, N., Hanrahan, J., Gorrell, M., Church, W. (2015). Kynurenine aminotransferases and the prospects of inhibitors for the treatment of schizophrenia. Current Medicinal Chemistry, 22(24), 2902-2918. [More Information]
  • Williams, K., Vieira de Ribeiro, A., Prakoso, E., Veillard, A., Shackel, N., Bu, Y., Brooks, B., Cavanagh, E., Raleigh, J., McLennan, S., McCaughan, G., Keane, F., Twigg, S., Gorrell, M., et al (2015). Lower serum fibroblast activation protein shows promise in the exclusion of clinically significant liver fibrosis due to non-alcoholic fatty liver disease in diabetes and obesity. Diabetes Research and Clinical Practice, 108(3), 466-472. [More Information]
  • Osborne, B., Yao, T., Wang, X., Chen, Y., Kotan, L., Nadvi, N., Herdem, M., McCaughan, G., Allen, J., Yu, M., Gorrell, M., et al (2014). A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. Biochimica et Biophysica Acta. Proteins and Proteomics, 1844 (7), 1248-1259. [More Information]
  • Nematollahi, A., Church, W., Nadvi, N., Gorrell, M., Sun, G. (2014). Homology Modeling of Human Kynurenine Aminotransferase III and Observations on Inhibitor Binding Using Molecular Docking. Central Nervous System Agents in Medicinal Chemistry, 14(1), 2-9. [More Information]
  • Keane, F., Yao, T., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]
  • Hamson, E., Keane, F., Tholen, S., Schilling, O., Gorrell, M. (2014). Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy. Proteomics - Clinical Applications, 8, 454-463. [More Information]
  • Zhang, H., Chen, Y., Keane, F., Gorrell, M. (2013). Advances in Understanding the Expression and Function of Dipeptidyl Peptidase 8 and 9. Molecular Cancer Research, 11(12), 1487-1496. [More Information]
  • Williams, K., Shackel, N., Gorrell, M., McLennan, S., Twigg, S. (2013). Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo. Endocrine Reviews, 34(1), 84-129. [More Information]
  • Harstad, E., Rosenblum, J., Gorrell, M., Achanzar, W., Minimo, L., Wu, J., Rosini-Marthaler, L., Gullo, R., Ordway, N., Kirby, M., et al (2013). DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues. Regulatory Peptides, 186, 26-35. [More Information]
  • Chowdhury, S., Chen, Y., Yao, T., Ajami, K., Wang, X., Popov, Y., Schuppan, D., Bertolino, P., McCaughan, G., Yu, M., Gorrell, M. (2013). Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World Journal of Gastroenterology, 19(19), 2883-2893. [More Information]
  • Gall, M., Chen, Y., Vieira de Ribeiro, A., Zhang, H., Bailey, C., Spielman, D., Yu, M., Gorrell, M. (2013). Targeted Inactivation of Dipeptidyl Peptidase 9 Enzymatic Activity Causes Mouse Neonate Lethality. PloS One, 8(11), 1-10. [More Information]
  • Akladios, F., Nadvi, N., Park, J., Hanrahan, J., Kapoor, V., Gorrell, M., Church, W. (2012). Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorganic & Medicinal Chemistry Letters, 22(4), 1579-1581. [More Information]
  • Yao, T., Kim, W., Yu, D., Sharbeen, G., McCaughan, G., Choi, K., Xia, P., Gorrell, M. (2011). A Novel Role of Dipeptidyl Peptidase 9 in Epidermal Growth Factor Signaling. Molecular Cancer Research, 9(7), 948-959. [More Information]
  • Lo, L., McLennan, S., Williams, P., Bonner, J., Chowdhury, S., McCaughan, G., Gorrell, M., Yue, D., Twigg, S. (2011). Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis. Journal of Hepatology, 55(2), 435-444. [More Information]
  • Song, S., Shackel, N., Wang, X., Ajami, K., McCaughan, G., Gorrell, M. (2011). Discoidin Domain Receptor 1: Isoform expression and potential functions in cirrhotic human liver. The American Journal of Pathology, 178(3), 1134-1144. [More Information]
  • Martin, J., Deacon, C., Gorrell, M., Prins, J. (2011). Incretin-based therapies - review of the physiology, pharmacology and emerging clinical experience. Internal Medicine Journal, 41(4), 299-307. [More Information]
  • Martin, J., Deacon, C., Gorrell, M., Prins, J. (2011). Incretin-based therapies - review of the physiology, pharmacology and emerging clinical experience. Internal Medicine Journal, 41(4), 299-307. [More Information]
  • Keane, F., Nadvi, N., Yao, T., Gorrell, M. (2011). Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α. The FEBS Journal, 278(8), 1316-1332. [More Information]
  • Yu, M., Slaitini, L., Gysbers, V., Riekhoff, A., Kähne, T., Knott, H., De Meester, I., Abbott, C., McCaughan, G., Gorrell, M. (2011). Soluble CD26/Dipeptidyl Peptidase IV Enhances Human Lymphocyte Proliferation In Vitro Independent of Dipeptidyl Peptidase Enzyme Activity and Adenosine Deaminase Binding. Scandinavian Journal of Immunology, 73(2), 102-111. [More Information]
  • Gorrell, M., Zekry, A., McCaughan, G., Lloyd, A. (2011). The long and the short of interferon-gamma-inducible protein 10 in hepatitis C virus infection. Hepatology, 54(5), 1875-1879. [More Information]
  • Kushner, P., Gorrell, M. (2010). DPP-4 Inhibitors in Type 2 Diabetes: Importance of Selective Enzyme Inhibition and Implications for Clinical Use. Journal Of Family Practice, 59(2).
  • Kirby, M., Yu, M., O'Connor, S., Gorrell, M. (2010). Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition. Clinical Science, 118(1), 31-41. [More Information]
  • Schuppan, D., Gorrell, M., Klein, T., Mark, M., Afdhal, N. (2010). The challenge of developing novel pharmacological therapies for non-alcoholic steatohepatitis. Liver International, 30(6), 795-808. [More Information]
  • Yu, M., Yao, T., Chowdhury, S., Nadvi, N., Osborne, B., Church, W., McCaughan, G., Gorrell, M. (2010). The dipeptidyl peptidase IV family in cancer and cell biology. The FEBS Journal, 277(5), 1126-1144. [More Information]
  • Sharland, A., Gorrell, M. (2009). Cooperation of innate and adaptive immunity in the pathogenesis of biliary atresia: There's a killer on the run. Hepatology (Baltimore Md.), 50(6), 2037-40. [More Information]
  • Manos, J., Arthur, J., Rose, B., Bell, S., Tingpej, P., Hu, H., Webb, J., Kjelleberg, S., Gorrell, M., Bye, P., Harbour, C. (2009). Gene expression characteristics of a cystic fibrosis epidemic strain of Pseudomonas aeruginosa during biofilm and planktonic growth. FEMS Microbiology Letters, 292(1), 107-114. [More Information]
  • Yu, M., Ajami, K., Gall, M., Park, J., Lee, C., Evans, K., McLaughlin, E., Pitman, M., Abbott, C., McCaughan, G., Gorrell, M. (2009). The In Vivo Expression of Dipeptidyl Peptidases 8 and 9. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, 57(11), 1025-1040. [More Information]
  • Devanshi, S., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2008). Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease. Journal of Hepatology, 48(4), 614-627. [More Information]
  • Wang, X., Yao, T., Nadvi, N., Osborne, B., McCaughan, G., Gorrell, M. (2008). Fibroblast activation protein and chronic liver disease. Frontiers in Bioscience, 13, 3168-3180. [More Information]
  • Gorrell, M. (2008). Impaired glucose tolerance and incretins in chronic liver disease. Journal of Gastroenterology and Hepatology, 23(2), 166-167. [More Information]
  • Neuman, M., Sha, K., Esguerra, R., Zakhari, S., Winkler, R., Hilzenrat, N., Wyse, J., Cooper, C., Seth, D., Gorrell, M., Haber, P., McCaughan, G., et al (2008). Inflammation and Repair in Viral Hepatitis C. Digestive Diseases and Sciences, 53(6), 1468-1487. [More Information]
  • Tran, D., Christiansen, D., Winterhalter, A., Brooks, A., Gorrell, M., Lilienfeld, B., Seebach, J., Sandrin, M., Sharland, A. (2008). Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D. Xenotransplantation, 15(5), 321-332. [More Information]
  • Park, J., Knott, H., Nadvi, N., Collyer, C., Wang, X., Church, W., Gorrell, M. (2008). Reversible Inactivation of Human Dipeptidyl Peptidases 8 and 9 by Oxidation. The Open Enzyme Inhibition Journal, 1, 52-60.
  • Ajami, K., Pitman, M., Wilson, C., Park, J., Menz, R., Starr, A., Cox, J., Abbott, C., Overall, C., Gorrell, M. (2008). Stromal cell-derived factors 1{alpha} and 1{beta}, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8. FEBS Letters, 582(5), 819-825. [More Information]
  • Manos, J., Arthur, J., Rose, B., Tingpej, P., Fung, C., Curtis, M., Webb, J., Hu, H., Kjelleberg, S., Gorrell, M., Bye, P., Harbour, C. (2008). Transcriptome analyses and biofilm-forming characteristics of a clonal Pseudomonas aeruginosa from the cystic fibrosis lung. Journal of Medical Microbiology, 57(12), 1454-1465. [More Information]
  • Gorrell, M., Warner, F. (2007). Fooling the liver: Malaria incognito. Hepatology, 45(3), 826-826. [More Information]
  • Gorrell, M. (2007). Liver fibrosis: The hepatocyte revisited. Hepatology (Baltimore Md.), 46(5), 1659-61. [More Information]
  • Huang, X., McCaughan, G., Shackel, N., Gorrell, M. (2007). Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis. Liver International, 27(7), 960-968. [More Information]
  • Park, J., Ajami, K., Yu, M., Gorrell, M. (2006). Dipeptidyl peptidase 8 has post-proline dipeptidyl aminopeptidase and prolyl endopeptidase activities. Advances in Experimental Medicine and Biology, 575, 93-102. [More Information]
  • Yu, M., Wang, X., Ajami, K., McCaughan, G., Gorrell, M. (2006). DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration and apoptosis. Advances in Experimental Medicine and Biology, 575, 63-72. [More Information]
  • Wang, X., Yu, M., McCaughan, G., Gorrell, M. (2006). Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin. Advances in Experimental Medicine and Biology, 575, 213-222. [More Information]
  • Yu, M., Wang, X., McCaughan, G., Gorrell, M. (2006). Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis. The FEBS Journal, 273(11), 2447-2460. [More Information]
  • Seth, D., Gorrell, M., Cordoba, S., McCaughan, G., Haber, P. (2006). Intrahepatic gene expression in human alcoholic hepatitis. Journal of Hepatology, 45(2), 306-320. [More Information]
  • Chen, T., Ajami, K., McCaughan, G., Gai, W., Gorrell, M., Abbott, C. (2006). Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity. Biochimica et Biophysica Acta, 1764 (1), 33-43. [More Information]
  • Seth, D., Beard, M., Gorrell, M., McCaughan, G., Haber, P. (2006). Osteopontin: An early marker for alcoholic liver injury? Alcoholism: Clinical and Experimental Research, 30(s2), 89A-89A.
  • Gorrell, M., Wang, X., Park, J., Ajami, K., Yu, M., Knott, H., Seth, D., McCaughan, G. (2006). Structure and function in dipeptidyl peptidase IV and related proteins. Advances in Experimental Medicine and Biology, 575, 45-54. [More Information]
  • Shackel, N., Seth, D., Haber, P., Gorrell, M., McCaughan, G. (2006). The hepatic transcriptome in human liver disease. Comparative Hepatology, 5, 6-6. [More Information]
  • Gorrell, M. (2005). Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders. Clinical Science, 108(4), 277-292. [More Information]
  • Wang, X., Yu, M., McCaughan, G., Gorrell, M. (2005). Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line. Hepatology, 42(4), 935-945. [More Information]
  • Ajami, K., Abbott, C., McCaughan, G., Gorrell, M. (2004). Dipeptidyl Peptidase 9 Has Two Forms, A Broad Tissue Distribution, Cytoplasmic Localization And DPIV-Like Peptidase Activity. Biochimica et Biophysica Acta, 1679 (1), 18-28. [More Information]
  • Cox, G., Kable, E., Jones, A., Fraser, I., Manconi, F., Gorrell, M. (2003). 3-Dimensional imaging of collagen using second harmonic generation. Journal of Structural Biology, 141(1), 53-62. [More Information]
  • Lorey, S., Stockel-Maschek, A., Faust, J., Brandt, W., Stiebitz, B., Gorrell, M., Kahne, T., Mrestani-Klaus, C., Wrenger, S., Reinhold, D., et al (2003). Different modes of dipetidyl pepidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites. The FEBS Journal, 270(10), 2147-2156.
  • Gorrell, M. (2003). First bite. Nature Structural and Molecular Biology, 10(1), 3-5. [More Information]
  • Seth, D., Leo, M., McGuinness, P., Lieber, C., Brennan, Y., Williams, R., Wang, X., McCaughan, G., Gorrell, M., Haber, P. (2003). Gene expression profiling of alcoholic liver disease in the Baboon (Papio hamadryas) and human liver. The American Journal of Pathology, 163(6), 2303-2317.
  • Shackel, N., McGuiness, P., Abbott, C., Gorrell, M., McCaughan, G. (2003). Novel differential gene expression in human cirrhosis detected by suppression substractive hybridization. Hepatology, 38(3), 577-588.
  • Haber, P., Warner, R., Seth, D., Gorrell, M., McCaughan, G. (2003). Pathogenesis and management of alcoholic hepatitis. Journal of Gastroenterology and Hepatology, 18(12), 1332-1344. [More Information]
  • Seth, D., Gorrell, M., McGuiness, P., Leo, M., Lieber, C., McCaughan, G., Haber, P. (2003). SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates. Journal Of Biochemical and Biophysical Methods, 55(1), 53-66. [More Information]
  • Ajami, K., Abbott, C., Obradovic, M., Gysbers, V., Kahne, T., McCaughan, G., Gorrell, M. (2003). Structural requirements for catalysis, expression, dimerization in the CD26/DPIV gene family. Biochemistry, 42(3), 694-701. [More Information]
  • Shackel, N., Gorrell, M., McCaughan, G. (2002). Gene array analysis and the liver. Hepatology, 36(6), 1313-1325. [More Information]
  • Wang, M., Gorrell, M., Abbott, C., Jaggi, R., Marguet, D., Dickinson, R. (2002). Hepatic covalent adduct formation with zomepirac in the CD26-deficient mouse. Journal of Gastroenterology and Hepatology, 17(1), 66-71. [More Information]
  • Shackel, N., McGuinness, P., Abbott, C., Gorrell, M., McCaughan, G. (2002). Insights into the pathobiology of hepatitis C virus-associated cirrhosis. The American Journal of Pathology, 160(2), 641-654.
  • Levy, M., McCaughan, G., Marinos, G., Gorrell, M. (2002). Intrahepatic expression of the hepatic stellate cell marker fibroblast activation protein correlates with the degree of fibrosis in hepatitis C virus infection. Liver International, 22(2), 93-101. [More Information]
  • McCaughan, G., Gorrell, M., Bishop, A., Abbott, C., Shackel, N., McGuinness, P., Levy, M., Sharland, A., Bowen, D., Yu, M., Slaitini, L., Napoli, J., et al (2000). Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunological Reviews, 174(1), 172-191.

Conferences

  • Banavar, M., Kable, E., Braet, F., Wang, X., Gorrell, M., Cox, G. (2006). Detection of Collagen by Second Harmonic Microscopy as a Diagnostic Tool for Liver Fibrosis. Multiphoton Microscopy in the Biomedical Sciences VI, Bellingham, Washington, USA: SPIE - International Society for Optical Engineering. [More Information]
  • Seth, D., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2006). Identification of novel therapeutic targets for alcoholic liver disease. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
  • Wang, X., Yu, D., Schnapp, A., Marguet, D., Cordoba, S., Retting, W., McCaughan, G., Gorrell, M. (2005). The role of fibroblast activation protein (FAP) in cell adhesion, migration and liver fibrosis. 56th Annual Meeting of the American Association for the Study of Liver Diseases, United States: John Wiley & Sons.

Patents

  • Abbott, C., Gorrell, M. (2011). Dipeptidyl Peptidases (Dpp8) (Japan). Patent No. 4748908.
  • Abbott, C., Gorrell, M. (2011). Dipeptidyl Peptidases (Dpp9) (USA). Patent No. 7888094.
  • Gorrell, M., Abbott, C. (2010). Nucleic Acid Molecules Encoding Prolyl Dipeptidyl Peptidases [Dipeptidyl Peptidases (Dpp9)]. Patent No. 7662944.
  • Abbott, C., Gorrell, M. (2007). Dipeptidyl Peptidases (Dpp9). Patent No. 1337629, 7276365. Austria, Belgium, Cyprus, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Monaco, Netherlands, Portugal, Spain, Sweden, Switzerland, Turkey, United Kingdom.
  • Abbott, C., Gorrell, M. (2006). Dipeptidyl Peptidases (Dpp8). Patent No. 1214344, 7148338. Austria, Belgium, Cyprus, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Monaco, Netherlands, Portugal, Spain, Sweden, Switzerland, United Kingdom.
  • Abbott, C., Gorrell, M. (2006). Patent No. 7148338.

2016

  • Chen, Y., Gall, M., Zhang, H., Keane, F., McCaughan, G., Yu, M., Gorrell, M. (2016). Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes. Experimental Cell Research, 342(1), 72-82. [More Information]
  • Wilson, C., Zhang, H., Gorrell, M., Abbott, C. (2016). Dipeptidyl peptidase 9 substrates and their discovery: Current progress and the application of mass spectrometry-based approaches. Biological Chemistry, 397(9), 837-856. [More Information]
  • Wong, P., Gall, M., Bachovchin, W., McCaughan, G., Keane, F., Gorrell, M. (2016). Neuropeptide Y is a physiological substrate of fibroblast activation protein: Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver cirrhosis and hepatocellular carcinoma. Peptides, 75, 80-95. [More Information]

2015

  • Williams, K., Vieira de Ribeiro, A., Prakoso, E., Veillard, A., Shackel, N., Brooks, B., Bu, Y., Cavanagh, E., Raleigh, J., McLennan, S., McCaughan, G., Keane, F., Gorrell, M., Twigg, S., et al (2015). Circulating Dipeptidyl Peptidase-4 Activity Correlates with Measures of Hepatocyte Apoptosis and Fibrosis in NAFLD in Type 2 Diabetes Mellitus and Obesity: A Dual Cohort Cross-Sectional Study. Journal of Diabetes, 7(6), 809-819. [More Information]
  • Zhang, H., Chen, Y., Wadham, C., McCaughan, G., Keane, F., Gorrell, M. (2015). Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1853 (2), 470-480. [More Information]
  • Zhang, H., Maqsudi, S., Rainczuk, A., Duffield, N., Lawrence, J., Keane, F., Justa-Schuch, D., Geiss-Friedlander, R., Gorrell, M., Stephens, A. (2015). Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis. The FEBS Journal, 282(19), 3737-3757. [More Information]
  • Jayawickrama, G., Sadig, R., Sun, G., Nematollahi, A., Nadvi, N., Hanrahan, J., Gorrell, M., Church, W. (2015). Kynurenine aminotransferases and the prospects of inhibitors for the treatment of schizophrenia. Current Medicinal Chemistry, 22(24), 2902-2918. [More Information]
  • Williams, K., Vieira de Ribeiro, A., Prakoso, E., Veillard, A., Shackel, N., Bu, Y., Brooks, B., Cavanagh, E., Raleigh, J., McLennan, S., McCaughan, G., Keane, F., Twigg, S., Gorrell, M., et al (2015). Lower serum fibroblast activation protein shows promise in the exclusion of clinically significant liver fibrosis due to non-alcoholic fatty liver disease in diabetes and obesity. Diabetes Research and Clinical Practice, 108(3), 466-472. [More Information]

2014

  • Osborne, B., Yao, T., Wang, X., Chen, Y., Kotan, L., Nadvi, N., Herdem, M., McCaughan, G., Allen, J., Yu, M., Gorrell, M., et al (2014). A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. Biochimica et Biophysica Acta. Proteins and Proteomics, 1844 (7), 1248-1259. [More Information]
  • Nematollahi, A., Church, W., Nadvi, N., Gorrell, M., Sun, G. (2014). Homology Modeling of Human Kynurenine Aminotransferase III and Observations on Inhibitor Binding Using Molecular Docking. Central Nervous System Agents in Medicinal Chemistry, 14(1), 2-9. [More Information]
  • Keane, F., Yao, T., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]
  • Hamson, E., Keane, F., Tholen, S., Schilling, O., Gorrell, M. (2014). Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy. Proteomics - Clinical Applications, 8, 454-463. [More Information]

2013

  • Zhang, H., Chen, Y., Keane, F., Gorrell, M. (2013). Advances in Understanding the Expression and Function of Dipeptidyl Peptidase 8 and 9. Molecular Cancer Research, 11(12), 1487-1496. [More Information]
  • Williams, K., Shackel, N., Gorrell, M., McLennan, S., Twigg, S. (2013). Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo. Endocrine Reviews, 34(1), 84-129. [More Information]
  • Abbott, C., Gorrell, M. (2013). Dipeptidyl Peptidase 8. In Neil D. Rawlings, Guy Salvesen (Eds.), Handbook of Proteolytic Enzymes: Volume 3, (pp. 3379-3384). London, United Kingdom: Elsevier. [More Information]
  • Harstad, E., Rosenblum, J., Gorrell, M., Achanzar, W., Minimo, L., Wu, J., Rosini-Marthaler, L., Gullo, R., Ordway, N., Kirby, M., et al (2013). DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues. Regulatory Peptides, 186, 26-35. [More Information]
  • Gorrell, M., Park, J. (2013). Fibroblast Activation Protein alpha. In Neil D. Rawlings, Guy Salvesen (Eds.), Handbook of Proteolytic Enzymes: Volume 3, (pp. 3395-3401). London, United Kingdom: Elsevier. [More Information]
  • Chowdhury, S., Chen, Y., Yao, T., Ajami, K., Wang, X., Popov, Y., Schuppan, D., Bertolino, P., McCaughan, G., Yu, M., Gorrell, M. (2013). Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World Journal of Gastroenterology, 19(19), 2883-2893. [More Information]
  • Gall, M., Chen, Y., Vieira de Ribeiro, A., Zhang, H., Bailey, C., Spielman, D., Yu, M., Gorrell, M. (2013). Targeted Inactivation of Dipeptidyl Peptidase 9 Enzymatic Activity Causes Mouse Neonate Lethality. PloS One, 8(11), 1-10. [More Information]

2012

  • Akladios, F., Nadvi, N., Park, J., Hanrahan, J., Kapoor, V., Gorrell, M., Church, W. (2012). Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorganic & Medicinal Chemistry Letters, 22(4), 1579-1581. [More Information]
  • Keane, F., Chowdhury, S., Yao, T., Nadvi, N., Gall, M., Chen, Y., Osborne, B., Ribeiro, A., Church, W., McCaughan, G., Gorrell, M., Yu, M. (2012). Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy. In Ben Dunn (Eds.), Proteinases as Drug Targets, (pp. 118-144). Cambridge, UK: RSC Publishing.

2011

  • Yao, T., Kim, W., Yu, D., Sharbeen, G., McCaughan, G., Choi, K., Xia, P., Gorrell, M. (2011). A Novel Role of Dipeptidyl Peptidase 9 in Epidermal Growth Factor Signaling. Molecular Cancer Research, 9(7), 948-959. [More Information]
  • Lo, L., McLennan, S., Williams, P., Bonner, J., Chowdhury, S., McCaughan, G., Gorrell, M., Yue, D., Twigg, S. (2011). Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis. Journal of Hepatology, 55(2), 435-444. [More Information]
  • Abbott, C., Gorrell, M. (2011). Dipeptidyl Peptidases (Dpp8) (Japan). Patent No. 4748908.
  • Abbott, C., Gorrell, M. (2011). Dipeptidyl Peptidases (Dpp9) (USA). Patent No. 7888094.
  • Song, S., Shackel, N., Wang, X., Ajami, K., McCaughan, G., Gorrell, M. (2011). Discoidin Domain Receptor 1: Isoform expression and potential functions in cirrhotic human liver. The American Journal of Pathology, 178(3), 1134-1144. [More Information]
  • Martin, J., Deacon, C., Gorrell, M., Prins, J. (2011). Incretin-based therapies - review of the physiology, pharmacology and emerging clinical experience. Internal Medicine Journal, 41(4), 299-307. [More Information]
  • Martin, J., Deacon, C., Gorrell, M., Prins, J. (2011). Incretin-based therapies - review of the physiology, pharmacology and emerging clinical experience. Internal Medicine Journal, 41(4), 299-307. [More Information]
  • Keane, F., Nadvi, N., Yao, T., Gorrell, M. (2011). Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-α. The FEBS Journal, 278(8), 1316-1332. [More Information]
  • Yu, M., Slaitini, L., Gysbers, V., Riekhoff, A., Kähne, T., Knott, H., De Meester, I., Abbott, C., McCaughan, G., Gorrell, M. (2011). Soluble CD26/Dipeptidyl Peptidase IV Enhances Human Lymphocyte Proliferation In Vitro Independent of Dipeptidyl Peptidase Enzyme Activity and Adenosine Deaminase Binding. Scandinavian Journal of Immunology, 73(2), 102-111. [More Information]
  • Gorrell, M., Zekry, A., McCaughan, G., Lloyd, A. (2011). The long and the short of interferon-gamma-inducible protein 10 in hepatitis C virus infection. Hepatology, 54(5), 1875-1879. [More Information]

2010

  • Kushner, P., Gorrell, M. (2010). DPP-4 Inhibitors in Type 2 Diabetes: Importance of Selective Enzyme Inhibition and Implications for Clinical Use. Journal Of Family Practice, 59(2).
  • Kirby, M., Yu, M., O'Connor, S., Gorrell, M. (2010). Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition. Clinical Science, 118(1), 31-41. [More Information]
  • Gorrell, M., Abbott, C. (2010). Nucleic Acid Molecules Encoding Prolyl Dipeptidyl Peptidases [Dipeptidyl Peptidases (Dpp9)]. Patent No. 7662944.
  • Schuppan, D., Gorrell, M., Klein, T., Mark, M., Afdhal, N. (2010). The challenge of developing novel pharmacological therapies for non-alcoholic steatohepatitis. Liver International, 30(6), 795-808. [More Information]
  • Yu, M., Yao, T., Chowdhury, S., Nadvi, N., Osborne, B., Church, W., McCaughan, G., Gorrell, M. (2010). The dipeptidyl peptidase IV family in cancer and cell biology. The FEBS Journal, 277(5), 1126-1144. [More Information]

2009

  • Sharland, A., Gorrell, M. (2009). Cooperation of innate and adaptive immunity in the pathogenesis of biliary atresia: There's a killer on the run. Hepatology (Baltimore Md.), 50(6), 2037-40. [More Information]
  • Manos, J., Arthur, J., Rose, B., Bell, S., Tingpej, P., Hu, H., Webb, J., Kjelleberg, S., Gorrell, M., Bye, P., Harbour, C. (2009). Gene expression characteristics of a cystic fibrosis epidemic strain of Pseudomonas aeruginosa during biofilm and planktonic growth. FEMS Microbiology Letters, 292(1), 107-114. [More Information]
  • Yu, M., Ajami, K., Gall, M., Park, J., Lee, C., Evans, K., McLaughlin, E., Pitman, M., Abbott, C., McCaughan, G., Gorrell, M. (2009). The In Vivo Expression of Dipeptidyl Peptidases 8 and 9. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, 57(11), 1025-1040. [More Information]

2008

  • Devanshi, S., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2008). Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease. Journal of Hepatology, 48(4), 614-627. [More Information]
  • Wang, X., Yao, T., Nadvi, N., Osborne, B., McCaughan, G., Gorrell, M. (2008). Fibroblast activation protein and chronic liver disease. Frontiers in Bioscience, 13, 3168-3180. [More Information]
  • Gorrell, M. (2008). Impaired glucose tolerance and incretins in chronic liver disease. Journal of Gastroenterology and Hepatology, 23(2), 166-167. [More Information]
  • Neuman, M., Sha, K., Esguerra, R., Zakhari, S., Winkler, R., Hilzenrat, N., Wyse, J., Cooper, C., Seth, D., Gorrell, M., Haber, P., McCaughan, G., et al (2008). Inflammation and Repair in Viral Hepatitis C. Digestive Diseases and Sciences, 53(6), 1468-1487. [More Information]
  • Tran, D., Christiansen, D., Winterhalter, A., Brooks, A., Gorrell, M., Lilienfeld, B., Seebach, J., Sandrin, M., Sharland, A. (2008). Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D. Xenotransplantation, 15(5), 321-332. [More Information]
  • Park, J., Knott, H., Nadvi, N., Collyer, C., Wang, X., Church, W., Gorrell, M. (2008). Reversible Inactivation of Human Dipeptidyl Peptidases 8 and 9 by Oxidation. The Open Enzyme Inhibition Journal, 1, 52-60.
  • Ajami, K., Pitman, M., Wilson, C., Park, J., Menz, R., Starr, A., Cox, J., Abbott, C., Overall, C., Gorrell, M. (2008). Stromal cell-derived factors 1{alpha} and 1{beta}, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8. FEBS Letters, 582(5), 819-825. [More Information]
  • Manos, J., Arthur, J., Rose, B., Tingpej, P., Fung, C., Curtis, M., Webb, J., Hu, H., Kjelleberg, S., Gorrell, M., Bye, P., Harbour, C. (2008). Transcriptome analyses and biofilm-forming characteristics of a clonal Pseudomonas aeruginosa from the cystic fibrosis lung. Journal of Medical Microbiology, 57(12), 1454-1465. [More Information]

2007

  • Abbott, C., Gorrell, M. (2007). Dipeptidyl Peptidases (Dpp9). Patent No. 1337629, 7276365. Austria, Belgium, Cyprus, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Monaco, Netherlands, Portugal, Spain, Sweden, Switzerland, Turkey, United Kingdom.
  • Gorrell, M., Warner, F. (2007). Fooling the liver: Malaria incognito. Hepatology, 45(3), 826-826. [More Information]
  • McCaughan, G., Shackel, N., Williams, R., Seth, D., Haber, P., Gorrell, M. (2007). Genomics, gene arrays and proteomics in the study of liver disease. In Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, and Mario Rizzetto (Eds.), The Textbook of Hepatology: From Basic Science to Clinical Practice, (pp. 398-420). USA: Blackwell Publishers.
  • Gorrell, M. (2007). Liver fibrosis: The hepatocyte revisited. Hepatology (Baltimore Md.), 46(5), 1659-61. [More Information]
  • Huang, X., McCaughan, G., Shackel, N., Gorrell, M. (2007). Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis. Liver International, 27(7), 960-968. [More Information]

2006

  • Banavar, M., Kable, E., Braet, F., Wang, X., Gorrell, M., Cox, G. (2006). Detection of Collagen by Second Harmonic Microscopy as a Diagnostic Tool for Liver Fibrosis. Multiphoton Microscopy in the Biomedical Sciences VI, Bellingham, Washington, USA: SPIE - International Society for Optical Engineering. [More Information]
  • Park, J., Ajami, K., Yu, M., Gorrell, M. (2006). Dipeptidyl peptidase 8 has post-proline dipeptidyl aminopeptidase and prolyl endopeptidase activities. Advances in Experimental Medicine and Biology, 575, 93-102. [More Information]
  • Abbott, C., Gorrell, M. (2006). Dipeptidyl Peptidases (Dpp8). Patent No. 1214344, 7148338. Austria, Belgium, Cyprus, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Monaco, Netherlands, Portugal, Spain, Sweden, Switzerland, United Kingdom.
  • Yu, M., Wang, X., Ajami, K., McCaughan, G., Gorrell, M. (2006). DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration and apoptosis. Advances in Experimental Medicine and Biology, 575, 63-72. [More Information]
  • Wang, X., Yu, M., McCaughan, G., Gorrell, M. (2006). Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin. Advances in Experimental Medicine and Biology, 575, 213-222. [More Information]
  • Yu, M., Wang, X., McCaughan, G., Gorrell, M. (2006). Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis. The FEBS Journal, 273(11), 2447-2460. [More Information]
  • Seth, D., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2006). Identification of novel therapeutic targets for alcoholic liver disease. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
  • Seth, D., Gorrell, M., Cordoba, S., McCaughan, G., Haber, P. (2006). Intrahepatic gene expression in human alcoholic hepatitis. Journal of Hepatology, 45(2), 306-320. [More Information]
  • Chen, T., Ajami, K., McCaughan, G., Gai, W., Gorrell, M., Abbott, C. (2006). Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity. Biochimica et Biophysica Acta, 1764 (1), 33-43. [More Information]
  • Abbott, C., Gorrell, M. (2006). Patent No. 7148338.
  • Seth, D., Beard, M., Gorrell, M., McCaughan, G., Haber, P. (2006). Osteopontin: An early marker for alcoholic liver injury? Alcoholism: Clinical and Experimental Research, 30(s2), 89A-89A.
  • Gorrell, M., Wang, X., Park, J., Ajami, K., Yu, M., Knott, H., Seth, D., McCaughan, G. (2006). Structure and function in dipeptidyl peptidase IV and related proteins. Advances in Experimental Medicine and Biology, 575, 45-54. [More Information]
  • Shackel, N., Seth, D., Haber, P., Gorrell, M., McCaughan, G. (2006). The hepatic transcriptome in human liver disease. Comparative Hepatology, 5, 6-6. [More Information]

2005

  • Gorrell, M. (2005). Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders. Clinical Science, 108(4), 277-292. [More Information]
  • Gorrell, M., Yu, M. (2005). Diverse functions in a conserved structure: The dipeptidyl peptidase IV gene family. In Robinson J (Eds.), Trends in Protein Research, (pp. 1-78). New York: Nova Biomedical Books.
  • Wang, X., Yu, M., McCaughan, G., Gorrell, M. (2005). Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line. Hepatology, 42(4), 935-945. [More Information]
  • Wang, X., Yu, D., Schnapp, A., Marguet, D., Cordoba, S., Retting, W., McCaughan, G., Gorrell, M. (2005). The role of fibroblast activation protein (FAP) in cell adhesion, migration and liver fibrosis. 56th Annual Meeting of the American Association for the Study of Liver Diseases, United States: John Wiley & Sons.

2004

  • Ajami, K., Abbott, C., McCaughan, G., Gorrell, M. (2004). Dipeptidyl Peptidase 9 Has Two Forms, A Broad Tissue Distribution, Cytoplasmic Localization And DPIV-Like Peptidase Activity. Biochimica et Biophysica Acta, 1679 (1), 18-28. [More Information]

2003

  • Cox, G., Kable, E., Jones, A., Fraser, I., Manconi, F., Gorrell, M. (2003). 3-Dimensional imaging of collagen using second harmonic generation. Journal of Structural Biology, 141(1), 53-62. [More Information]
  • Stockel-Maschek, A., Stiebitz, B., Faust, J., Born, I., Kahne, T., Gorrell, M., Neubert, K. (2003). Different inhibition mechanisms of dipeptidyl peptidaseIV by tryptophan containing peptides and amides. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 69-72). NY: Springer.
  • Lorey, S., Stockel-Maschek, A., Faust, J., Brandt, W., Stiebitz, B., Gorrell, M., Kahne, T., Mrestani-Klaus, C., Wrenger, S., Reinhold, D., et al (2003). Different modes of dipetidyl pepidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites. The FEBS Journal, 270(10), 2147-2156.
  • Chen, T., Ajami, K., McCaughan, G., Gorrell, M., Abbott, C. (2003). Dipeptidyl peptidase IV gene family. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 79-88). NY: Springer.
  • Gorrell, M. (2003). First bite. Nature Structural and Molecular Biology, 10(1), 3-5. [More Information]
  • Seth, D., Leo, M., McGuinness, P., Lieber, C., Brennan, Y., Williams, R., Wang, X., McCaughan, G., Gorrell, M., Haber, P. (2003). Gene expression profiling of alcoholic liver disease in the Baboon (Papio hamadryas) and human liver. The American Journal of Pathology, 163(6), 2303-2317.
  • Gorrell, M., Wang, X., Levy, M., Kable, E., Marinos, G., Cox, G., McCaughan, G. (2003). Intrahepatic expression of collagen and fibroblast activation protein (FAP) in hepatitis C virus infection. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 235-243). NY: Springer.
  • Ajami, K., Abbott, C., Gysbers, V., Kaehne, T., McCaughan, G., Gorrell, M. (2003). Molecular chimeras and mutational analysis in the prolyl oligopeptidase gene family. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 49-55). NY: Springer.
  • Shackel, N., McGuiness, P., Abbott, C., Gorrell, M., McCaughan, G. (2003). Novel differential gene expression in human cirrhosis detected by suppression substractive hybridization. Hepatology, 38(3), 577-588.
  • Haber, P., Warner, R., Seth, D., Gorrell, M., McCaughan, G. (2003). Pathogenesis and management of alcoholic hepatitis. Journal of Gastroenterology and Hepatology, 18(12), 1332-1344. [More Information]
  • Seth, D., Gorrell, M., McGuiness, P., Leo, M., Lieber, C., McCaughan, G., Haber, P. (2003). SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates. Journal Of Biochemical and Biophysical Methods, 55(1), 53-66. [More Information]
  • Ajami, K., Abbott, C., Obradovic, M., Gysbers, V., Kahne, T., McCaughan, G., Gorrell, M. (2003). Structural requirements for catalysis, expression, dimerization in the CD26/DPIV gene family. Biochemistry, 42(3), 694-701. [More Information]

2002

  • Shackel, N., Gorrell, M., McCaughan, G. (2002). Gene array analysis and the liver. Hepatology, 36(6), 1313-1325. [More Information]
  • Wang, M., Gorrell, M., Abbott, C., Jaggi, R., Marguet, D., Dickinson, R. (2002). Hepatic covalent adduct formation with zomepirac in the CD26-deficient mouse. Journal of Gastroenterology and Hepatology, 17(1), 66-71. [More Information]
  • Shackel, N., McGuinness, P., Abbott, C., Gorrell, M., McCaughan, G. (2002). Insights into the pathobiology of hepatitis C virus-associated cirrhosis. The American Journal of Pathology, 160(2), 641-654.
  • Levy, M., McCaughan, G., Marinos, G., Gorrell, M. (2002). Intrahepatic expression of the hepatic stellate cell marker fibroblast activation protein correlates with the degree of fibrosis in hepatitis C virus infection. Liver International, 22(2), 93-101. [More Information]
  • Abbott, C., Gorrell, M. (2002). The family of CD26/DPIV and related ectopeptidases: the DPIV family. In J Langner, S Ansorge (Eds.), Ectopeptises: CD13/Aminopeptidase N and CD26/Dipeptidylpeptidase IV in Medicine and Biology, (pp. 171-194). New York, USA: Staempfli Publishers Ltd.

2000

  • McCaughan, G., Gorrell, M., Bishop, A., Abbott, C., Shackel, N., McGuinness, P., Levy, M., Sharland, A., Bowen, D., Yu, M., Slaitini, L., Napoli, J., et al (2000). Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunological Reviews, 174(1), 172-191.

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