People_

Professor Mark Gorrell

Professor of Liver Science

Phone

+61 2 9565 6152

Fax

+61 2 9565 6101

Email

mark.gorrell@sydney.edu.au

Details

Member of The Centre for Drug Discovery Innovation

Member of the Charles Perkins Centre

Websites

Centenary Institute

The University of Sydney

Resume

Curriculum vitae

Biographical details

Professor Mark Gorrell heads the Liver Enzymes in Metabolism and Inflammation Program of Centenary Institute. He trained in cell biology, virology, immunology and protein biochemistry at Australian National University, University of Melbourne and Johns Hopkins University. His research is focussed upon liver cancer prevention and treatment, chronic liver disease pathogenesis, diabetes, and protein and enzyme biochemistry and cell biology related to the proteases DPP4, DPP9 and fibroblast activation protein (FAP). He has authored over 178 publications attracting H index 51, i10 index 127 and > 10400 citations. His research experience also includes small RNA viruses, transcriptomics, proteomics and cell biology. His research was important in the development of DPP4-targetted therapies for type 2 diabetes, which are now used to treat millions of patients. Inside Centenary Institute, he chairs the postgraduate research committee, is a Commercialisation Committee member. Outside Centenary Institute, he is active in the International Proteolysis Society, the Gastroenterological Society of Australia, NHMRC, MRFF and Flanders Fund grant reviews, and editorial boards of journals including Cancers andScientific Reports.

Research interests

Professor Mark D. Gorrell is devoted to understanding the functions of the dipeptidyl peptidase IV [DPP4] gene family enzymes and the molecular basis of chronic liver disease, including cancer, and how to exploit this knowledge to alleviate human illness. DPP4 is the target of a successful new type 2 diabetes therapy that is benefiting millions of patients.

With colleagues, he discovered that DPP4 modifies the activities of several chemokines [1997 J Exp Med]. He discovered DPP8, DPP9 and DPP10 (2000 FEBS J; 2004 BBA; 2006 BBA) allowing the development of DPP4 selective inhibitors for diabetes therapy, and FAP inhibitors for tumour imaging. His work on DPP4 and DPP9 provided key insights into the safety of DPP4 inhibitors in clinical use [Scand J Immunol; PlosOne]. He also discovered novel substrate recognition sites in DPPs used in drug development, ligand binding sites on DPP4 that are binding sites of MERS virus, and constructed the first DPP4 protein structure prediction [1999 FEBS J; FEBS Lett].

His team showed that DPP4, FAP and DPP9 amplify cell death signals and alter cell adhesion [FEBS J; Hepatology; Mol Cancer Res; BBA-MCR], identified several chemokines cut by DPP8, and identified most of the known substrates of FAP [FEBS J; Peptides; 2019 Mol Cell Proteomics] and DPP9 [FEBS J]. He found that the levels of FAP in human blood specifically correspond to the presence of liver fibrosis and developed this into diagnostic blood test.

He found that mice lacking DPP9 die soon after birth and that these mice have metabolism defects [2013 PlosOne; 2016 Expl Cell Res]. He found that DPP9 is not essential for an intact immune system in adult mice [2019 Sci Rep]. Showed that humans are very likely similar [2021 Cancers] and, in a consortium, that severe DPP9 deficiency in humans causes a severe immune deficiency [2022 Scince Immunology].

He uses mouse models of fatty liver and NASH [2011 J Hepatol], liver fibrosis and liver cancer [2018 Sci Rep].

Teaching and supervision

I have supervised honours, postgraduate and undergraduate research students in topics related to those in which I have published. This includes biochemistry, cell biology, and mouse models of fatty liver, liver fibrosis and primary and liver cancer. I also develop improved diagnosis of liver fibrosis in patients. Currently, I have no open positions but assist with supervision of students supervised by Dr B Boumelhem.

I am recipient of the 2018 Sydney Research Supervisor award and a 2019 SUPRA Postgraduate Research Coordinator of the Year award.

Current projects

Current projects focus on fibrosis and fatty liver in chronic liver diseases, primary liver cancer and type 2 diabetes and the functions of FAP, DPP4 and DPP9.

Currently, there are no open positions.

Associations

American Association for the Study of Liver Diseases [AASLD] since 2018
European Association for the Study of Liver [EASL] since 2016.
Australia & New Zealand Society for Cell and Developmental Biology (ANZSCDBI) since 1989. (Governing Committee member 1994-1998, Treasurer 1994-1996).
Australian Society for Biochemistry and Molecular Biology (ASBMB) since 2002.
Australian Society for Immunology 1980 - 2019.
Gastroenterological Society of Australia since 1996. Research Committee member 2013-17.
International Proteolysis Society since 2000. Treasurer and Governing Council member 2011-2015 and 2023-2027.
The Sydney Protein Group since 1989.
American Society for Virology (ASV) member since 1990 and Life Member since 2004.

Awards and honours

Current awards:

2021-2 DAAD (Deutscher Akademischer Austauschdienst) / Universities Australia Australia–Germany Joint Research Cooperation Scheme grant ID57559557Degradomics in NASH. Prof Gorrell & Prof Schilling .

2020 Centenary Institute Recognition Award to Mark Gorrell for excellence in higher degree research management.

2021-3 Philanthropic grant. “DPP4 and related proteases”. MD Gorrell

2021 and 2016: Outstanding Editorial Board Member of World Journal of Gastroenterology(IF 5.74), with photograph on front cover of journal.

2022-3 Australian Cancer Research Foundation grant. Molecular Theranostics Laboratory. Professors Philip Hogg, John Simes, Mark Gorrell, Geoffrey W McCaughan, Rachel Codd, Martin Stockler.

2022 ACH2 project grant. Fibrosis in HBV. Avik Majumdar, Mark Gorrell, Jessica Howell, Geoff McCaughan.

2022-3 USyd-UEdin Partnership Collaboration Award.Understanding human enzymes in severe lung infections. Professors Mark Gorrell and Kenneth Baillie, with Dr B Boumelhem and Dr S Biddie.

Recent awards:

2018 Award for Research Student Supervision in medical and health research. Awarded bySydney Research to Prof Mark Gorrell

2019 Sydney University Postgraduate Research Association Postgraduate Research Coordinator of the Year

2016-20 NHMRC Project Grant 1105238. “DPP4 family proteases as driversof chronic liver injury”. A/Pr MD Gorrell, Prof GW McCaughan, Prof S Twigg, Prof WW Bachovchin.

2016-18 NHMRC Project Grant 1099375. “Diabetes drug for ovarian cancer”. A/Pr Magdelina Plebanski, Dr Andrew N Stephens, Prof Martin Oehler, A/Pr MD Gorrell.

2016-18 NHMRC Development Grant 1113842. “A novel liver cancer therapytargeting tumour stroma”. A/Pr MD Gorrell, Prof GW McCaughan.

Themes

Obesity, Diabetes and Cardiovascular Disease, Cancer, Healthy Ageing

Keywords

Cancer, Cell biology, Diabetes, Liver fibrosis, fatty liver

Approaches

Animal Models, Cellular/Molecular, Pathogenesis

International links

Australia	(Flinders University School of Biological Sciences) research collaboration on dipeptidyl peptidases
Australia	(University of Sydney Endocrinology) research collaboration on FAP-alpha and DPP4 in diabetes complications
Germany	(University of Freiburg) collaborative basic research on FAP
Germany	(University of Freiburg) Dr Ruth Geiss-Friedlander: DPP9
Singapore	(National University of Singapore) Human genetics of DPP9. Prof Bruno Reversade.
United States	(Tufts University) collaborative research

PhD and master's project opportunities

Biology of Dipeptidyl Peptidase IV and related proteins

Current research students

Project title	Research student
The protease dipeptidyl peptidase 9 in lung pathogenesis	Jasmine NGUYEN
Understanding Dipeptidyl Peptidase-9 in Human liver cancer and hepatitis	Mingchang ZHANG

Publications

By Type

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Book Chapters

Gorrell, M., Zhang, H. (2018). Dipeptidyl Peptidase 8. Encyclopedia of Signaling Molecules - 2nd Edition, (pp. 1414-1417). Cham: Springer International Publishing. [More Information]
Zhang, H., Gorrell, M. (2018). Dipeptidyl Peptidase 9. Encyclopedia of Signaling Molecules - 2nd Edition, (pp. 1418-1422). Cham: Springer International Publishing. [More Information]
Polak, N., Gorrell, M. (2018). Fibroblast activation protein. Encyclopedia of Signaling Molecules - 2nd Edition, (pp. 1676-1681). Cham: Springer International Publishing. [More Information]
Gall, M., Gorrell, M. (2017). The Multifunctional Post-proline Dipeptidyl Peptidase, DPP9, in Mice, Cell Biology and Immunity. In Sajal Chakraborti and Naranjan S. Dhalla (Eds.), Pathophysiological Aspects of Proteases, (pp. 23-45). Singapore: Springer. [More Information]
Abbott, C., Gorrell, M. (2013). Dipeptidyl Peptidase 8. In Neil D. Rawlings, Guy Salvesen (Eds.), Handbook of Proteolytic Enzymes: Volume 3, (pp. 3379-3384). London, United Kingdom: Elsevier. [More Information]
Gorrell, M., Park, J. (2013). Fibroblast Activation Protein alpha. In Neil D. Rawlings, Guy Salvesen (Eds.), Handbook of Proteolytic Enzymes: Volume 3, (pp. 3395-3401). London, United Kingdom: Elsevier. [More Information]
Keane, F., Chowdhury, S., Yao, T., Nadvi, N., Gall, M., Chen, Y., Osborne, B., Ribeiro, A., Church, W., McCaughan, G., Gorrell, M., Yu, M. (2012). Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy. In Ben Dunn (Eds.), Proteinases as Drug Targets, (pp. 118-144). Cambridge, UK: RSC Publishing. [More Information]
McCaughan, G., Shackel, N., Williams, R., Seth, D., Haber, P., Gorrell, M. (2007). Genomics, gene arrays and proteomics in the study of liver disease. In Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, and Mario Rizzetto (Eds.), The Textbook of Hepatology: From Basic Science to Clinical Practice, (pp. 398-420). USA: Blackwell Publishers. [More Information]
Gorrell, M., Yu, M. (2005). Diverse functions in a conserved structure: The dipeptidyl peptidase IV gene family. In Robinson J (Eds.), Trends in Protein Research, (pp. 1-78). New York: Nova Biomedical Books.
Stockel-Maschek, A., Stiebitz, B., Faust, J., Born, I., Kahne, T., Gorrell, M., Neubert, K. (2003). Different inhibition mechanisms of dipeptidyl peptidaseIV by tryptophan containing peptides and amides. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 69-72). NY: Springer.
Chen, T., Ajami, K., McCaughan, G., Gorrell, M., Abbott, C. (2003). Dipeptidyl peptidase IV gene family. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 79-88). NY: Springer.
Gorrell, M., Wang, X., Levy, M., Kable, E., Marinos, G., Cox, G., McCaughan, G. (2003). Intrahepatic expression of collagen and fibroblast activation protein (FAP) in hepatitis C virus infection. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 235-243). NY: Springer.
Ajami, K., Abbott, C., Gysbers, V., Kaehne, T., McCaughan, G., Gorrell, M. (2003). Molecular chimeras and mutational analysis in the prolyl oligopeptidase gene family. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 49-55). NY: Springer.
Abbott, C., Gorrell, M. (2002). The family of CD26/DPIV and related ectopeptidases: the DPIV family. In J Langner, S Ansorge (Eds.), Ectopeptises: CD13/Aminopeptidase N and CD26/Dipeptidylpeptidase IV in Medicine and Biology, (pp. 171-194). New York, USA: Staempfli Publishers Ltd.

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Journals

Ly, M., Lau, N., Dennis, C., Chen, J., Risbey, C., Tan, S., Chen, R., Wang, C., Gorrell, M., McKenzie, C., Kench, J., Liu, K., McCaughan, G., Crawford, M., Pulitano, C. (2025). Long Term Ex-Situ Normothermic Machine Perfusion Allows Regeneration of Human Livers with Severe Bile Duct Injury. American Journal Of Transplantation, 25(1), 60-71. [More Information]
Hargett, S., Shrestha, R., Janitz, M., Gorrell, M., Bruce, C., Wilkins, M., Hoehn, K., Byrne, F., Lahiri, S., Kowalski, G., et al (2024). Bile acids mediate fructose-associated liver tumour growth in mice. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870 (3), 167029. [More Information]
Liu, X., Huang, Y., Liu, D., Jiang, Y., Zhao, M., Chung, L., Han, X., Zhao, Y., Chen, J., Coleman, P., Ting, K., Tran, C., Su, Y., Don, A., Vadas, M., Gorrell, M., Murray, M., Kavurma, M., McCaughan, G., Gamble, J., Qi, Y., et al (2024). Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis. Journal of Translational Medicine, 22(1), 43. [More Information]
Liu, X., Chung, L., Liu, D., Chen, J., Huang, Y., Teo, J., Han, X., Zhao, Y., Guan, F., Tran, C., Lee, J., Couttas, T., McCaughan, G., Gorrell, M., Don, A., Qi, Y., et al (2022). Ablation of sphingosine kinase 2 suppresses fatty liver- associated hepatocellular carcinoma via downregulation of ceramide transfer protein. Oncogenesis, 11(1), 1-12. [More Information]
Jaenisch, S., Abbott, C., Gorrell, M., Bampton, P., Butler, R., Yazbeck, R. (2022). Circulating Dipeptidyl Peptidase Activity Is a Potential Biomarker for Inflammatory Bowel Disease. Clinical and Translational Gastroenterology, 13(1), E00452. [More Information]
Bolgi, O., Weiss, K., Donzelli, L., Gorrell, M., Grade, M., Riemer, J., Urlaub, H., Dobbelstein, M., Huber, R., Geiss-Friedlander, R., et al (2022). Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair. EMBO Reports, 23(10), e54136. [More Information]
Harapas, C., Robinson, K., Lay, K., Wong, J., Traspas, R., Nabavizadeh, N., Rass-Rothschild, A., Boisson, B., Drutman, S., Laohamonthonkul, P., Gorrell, M., et al (2022). DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling. Science Immunology, 7(75). [More Information]
Ren, J., Wang, X., Yee, C., Gorrell, M., McLennan, S., Twigg, S. (2022). Sitagliptin Is More Effective Than Gliclazide in Preventing Pro-Fibrotic and Pro-Inflammatory Changes in a Rodent Model of Diet-Induced Non-Alcoholic Fatty Liver Disease. Molecules, 27(3), 727. [More Information]
Ren, J., Wang, X., Parry, S., Yee, C., Gorrell, M., McLennan, S., Twigg, S. (2022). Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes. Journal of Cell Communication and Signaling, 16(3), 447-460. [More Information]
Xi, C., Di Fazio, A., Nadvi, N., Xiang, M., Zhang, H., Deshpande, C., Chen, Y., Sharifi Tabar, M., Wang, X., Bailey, C., McCaughan, G., Church, W., Gorrell, M. (2021). An improved production and purification protocol for recombinant soluble human fibroblast activation protein alpha. Protein Expression and Purification, 181, 1-8. [More Information]
Stein, S., Weber, J., Nusser-Stein, S., Pahla, J., Zhang, H., Mohammed, S., Oppi, S., Gaul, D., Paneni, F., Tailleux, A., et al (2021). Deletion of fibroblast activation protein provides atheroprotection. Cardiovascular Research, 117(4), 1060-1069. [More Information]
Chen, H., Li, G., Chan, Y., Zhang, H., Gorrell, M., Pollock, C., Saad, S., Oliver, B. (2021). Differential Effects of Vaping' on Lipid and Glucose Profiles and Liver Metabolic Markers in Obese Versus Non-obese Mice. Frontiers in Physiology, 12, 755124. [More Information]
Henderson, J., Xiang, M., Huang, C., Wetzel, S., Jiang, L., Lai, J., Wu, W., Kench, J., Bachovchin, W., Roediger, B., McCaughan, G., Zhang, H., Gorrell, M. (2021). Dipeptidyl peptidase inhibition enhances cd8 t cell recruitment and activates intrahepatic inflammasome in a murine model of hepatocellular carcinoma. Cancers, 13(21), 5495. [More Information]
Wilson, A., Moffitt, L., Wilson, K., Bilandzic, M., Wright, M., Gorrell, M., Oehler, M., Plebanski, M., Stephens, A. (2021). DPP4 inhibitor sitagliptin enhances lymphocyte recruitment and prolongs survival in a syngeneic ovarian cancer mouse model. Cancers, 13(3), 1-18. [More Information]
Huang, C., Emran, A., Endaya, J., McCaughan, G., Gorrell, M., Zhang, H. (2021). Dpp9: Comprehensive in silico analyses of loss of function gene variants and associated gene expression signatures in human hepatocellular carcinoma. Cancers, 13(7), 1637-1-1637-18. [More Information]
Xi, C., Di Fazio, A., Nadvi, N., Patel, K., Xiang, M., Zhang, H., Deshpande, C., Low, J., Chen, Y., McMillan, C., Osborne, B., Vieira de Ribeiro, A., McCaughan, G., Mackay, J., Church, W., Gorrell, M., et al (2020). A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2. Molecules, 25(22). [More Information]
Johansen, M., Irving, A., Montagutelli, X., Tate, M., Rudloff, I., Nold, M., Hansbro, N., Kim, R., Donovan, C., Liu, G., McCaughan, G., Gorrell, M., Cole, A., Moreno, C., Le Couteur, D., Hesselson, D., Triccas, J., Neely, G., Gamble, J., Simpson, S., et al (2020). Animal and translational models of SARS-CoV-2 infection and COVID-19. Mucosal Immunology, 13(6), 877-891. [More Information]
Bassendine, M., Bridge, S., McCaughan, G., Gorrell, M. (2020). Covid-19 and co-morbidities: a role for Dipeptidyl Peptidase 4 (DPP4) in disease severity? Journal of Diabetes, 12(9), 649-658. [More Information]
Moffitt, L., Bilandzic, M., Wilson, A., Chen, Y., Gorrell, M., Oehler, M., Plebanski, M., Stephens, A. (2020). Hypoxia regulates dpp4 expression, proteolytic inactivation, and shedding from ovarian cancer cells. International Journal of Molecular Sciences, 21(21), 1-14. [More Information]
Zhang, H., Henderson, J., Gorrell, M. (2019). Animal models for hepatocellular carcinoma. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1865 (5), 993-1002. [More Information]
Lay, A., Zhang, H., McCaughan, G., Gorrell, M. (2019). Fibroblast activation protein in liver fibrosis. Frontiers in Bioscience, 24, 1-17. [More Information]
Zhang, H., Hamson, E., Koczorowska, M., Tholen, S., Chowdhury, S., Bailey, C., Lay, A., Twigg, S., Lee, Q., Roediger, B., O'Rourke, M., McCaughan, G., Keane, F., Gorrell, M., et al (2019). Identification of novel natural substrates of fibroblast activation protein-alpha by differential degradomics and proteomics. Molecular and Cellular Proteomics, 18(1), 65-85. [More Information]
Gall, M., Zhang, H., Lee, Q., Jolly, C., McCaughan, G., Cook, A., Roediger, B., Gorrell, M. (2019). Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity. Scientific Reports, 9(1), 1-10. [More Information]
Wilson, A., Wilson, K., Bilandzic, M., Moffitt, L., Makanji, M., Gorrell, M., Oehler, M., Rainczuk, A., Stephens, A., Plebanski, M. (2019). Non-Invasive Fluorescent Monitoring of Ovarian Cancer in an Immunocompetent Mouse Model. Cancers, 11(1), 1-19. [More Information]
Roediger, B., Lee, Q., Tikoo, S., Cobbin, J., Henderson, J., Jormakka, M., O'Rourke, M., Padula, M., Pinello, N., Henry, M., Wynne, M., Lisowski, L., Tay, S., Harris, D., Bertolino, P., Wong, J., Gorrell, M., Holmes, E., Jolly, C., Weninger, W., et al (2018). An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis. Cell, 175(2), 530-540. [More Information]
Zhang, H., Brewer, K., Jeffrey, G., Twigg, S., McGaughan, G., Williams, K., Adams, L., Gorrell, M. (2018). Circulating Fibroblast Activation Protein activity as a liver fibrosis biomarker in NAFLD. Journal of Hepatology, 66(1), S666-S667. [More Information]
Sinnathura, P., Lau, W., Vieira de Ribeiro, A., Bachovchin, W., Englert, H., Howe, G., Spencer, D., Manolios, N., Gorrell, M. (2018). Circulating fibroblast activation protein and dipeptidyl peptidase 4 in rheumatoid arthritis and systemic sclerosis. International Journal of Rheumatic Diseases, 21(11), 1915-1923. [More Information]
Cook, S., Lee, Q., Wong, A., Spann, B., Vincent, J., Wong, J., Schlitzer, A., Gorrell, M., Weninger, W., Roediger, B. (2018). Differential chemokine receptor expression and usage by pre-cDC1 and pre-cDC2. Immunology and Cell Biology, 96(10), 1131-1139. [More Information]
Zhang, H., Gall, M., Gorrell, M. (2018). Letter to Editor. Developmental Biology, 439(1), 1. [More Information]
Henderson, J., Polak, N., Chen, J., Roediger, B., Weninger, W., Kench, J., McCaughan, G., Zhang, H., Gorrell, M. (2018). Multiple liver insults synergize to accelerate experimental hepatocellular carcinoma. Scientific Reports, 8(1), 1-12. [More Information]
De Willige, S., Keane, F., Bowen, D., Malfliet, J., Zhang, H., Maneck, B., McCaughan, G., Leebeek, F., Rijken, D., Gorrell, M. (2017). Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease. PloS One, 12(6), 1-8. [More Information]
Tan, S., Chowdhury, S., Polak, N., Gorrell, M., Weninger, W. (2017). Fibroblast activation protein is dispensable in the anti-influenza immune response in mice. PloS One, 12(2), 1-15. [More Information]
Henderson, J., Zhang, H., Polak, N., Gorrell, M. (2017). Hepatocellular carcinoma: Mouse models and the potential roles of proteases. Cancer Letters, 387, 106-113. [More Information]
Nadvi, N., Salam, N., Park, J., Akladios, F., Kapoor, V., Collyer, C., Gorrell, M., Church, W. (2017). High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate. Protein Science, 26(4), 727-736. [More Information]
Jayawickrama, G., Nematollahi, A., Sun, G., Gorrell, M., Church, W. (2017). Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives. Scientific Reports, 7(1), 1-11. [More Information]
Wang, X., Holz, L., Chowdhury, S., Cordoba, S., Evans, K., Gall, M., Vieira de Ribeiro, A., Zheng, Y., Levy, M., Yu, M., Yao, T., Polak, N., Jolly, C., Bertolino, P., McCaughan, G., Gorrell, M. (2017). The pro-fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride-induced experimental liver injury. Immunology and Cell Biology, 95(5), 443-453. [More Information]
Chen, Y., Gall, M., Zhang, H., Keane, F., McCaughan, G., Yu, M., Gorrell, M. (2016). Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes. Experimental Cell Research, 342(1), 72-82. [More Information]
Wilson, C., Zhang, H., Gorrell, M., Abbott, C. (2016). Dipeptidyl peptidase 9 substrates and their discovery: Current progress and the application of mass spectrometry-based approaches. Biological Chemistry, 397(9), 837-856. [More Information]
Wong, P., Gall, M., Bachovchin, W., McCaughan, G., Keane, F., Gorrell, M. (2016). Neuropeptide Y is a physiological substrate of fibroblast activation protein: Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver cirrhosis and hepatocellular carcinoma. Peptides, 75, 80-95. [More Information]
Williams, K., Vieira de Ribeiro, A., Prakoso, E., Veillard, A., Shackel, N., Brooks, B., Bu, Y., Cavanagh, E., Raleigh, J., McLennan, S., McCaughan, G., Keane, F., Gorrell, M., Twigg, S., et al (2015). Circulating Dipeptidyl Peptidase-4 Activity Correlates with Measures of Hepatocyte Apoptosis and Fibrosis in NAFLD in Type 2 Diabetes Mellitus and Obesity: A Dual Cohort Cross-Sectional Study. Journal of Diabetes, 7(6), 809-819. [More Information]
Zhang, H., Chen, Y., Wadham, C., McCaughan, G., Keane, F., Gorrell, M. (2015). Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1853 (2), 470-480. [More Information]
Zhang, H., Maqsudi, S., Rainczuk, A., Duffield, N., Lawrence, J., Keane, F., Justa-Schuch, D., Geiss-Friedlander, R., Gorrell, M., Stephens, A. (2015). Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis. FEBS Journal, 282(19), 3737-3757. [More Information]
Jayawickrama, G., Sadig, R., Sun, G., Nematollahi, A., Nadvi, N., Hanrahan, J., Gorrell, M., Church, W. (2015). Kynurenine aminotransferases and the prospects of inhibitors for the treatment of schizophrenia. Current Medicinal Chemistry, 22(24), 2902-2918. [More Information]
Williams, K., Vieira de Ribeiro, A., Prakoso, E., Veillard, A., Shackel, N., Bu, Y., Brooks, B., Cavanagh, E., Raleigh, J., McLennan, S., McCaughan, G., Keane, F., Twigg, S., Gorrell, M., et al (2015). Lower serum fibroblast activation protein shows promise in the exclusion of clinically significant liver fibrosis due to non-alcoholic fatty liver disease in diabetes and obesity. Diabetes Research and Clinical Practice, 108(3), 466-472. [More Information]
Osborne, B., Yao, T., Wang, X., Chen, Y., Kotan, L., Nadvi, N., Herdem, M., McCaughan, G., Allen, J., Yu, M., Gorrell, M., et al (2014). A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. Biochimica et Biophysica Acta. Proteins and Proteomics, 1844 (7), 1248-1259. [More Information]
Nematollahi, A., Church, W., Nadvi, N., Gorrell, M., Sun, G. (2014). Homology Modeling of Human Kynurenine Aminotransferase III and Observations on Inhibitor Binding Using Molecular Docking. Central Nervous System Agents in Medicinal Chemistry, 14(1), 2-9. [More Information]
Keane, F., Yao, T., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]
Hamson, E., Keane, F., Tholen, S., Schilling, O., Gorrell, M. (2014). Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy. Proteomics - Clinical Applications, 8, 454-463. [More Information]
Zhang, H., Chen, Y., Keane, F., Gorrell, M. (2013). Advances in Understanding the Expression and Function of Dipeptidyl Peptidase 8 and 9. Molecular Cancer Research, 11(12), 1487-1496. [More Information]
Williams, K., Shackel, N., Gorrell, M., McLennan, S., Twigg, S. (2013). Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo. Endocrine Reviews, 34(1), 84-129. [More Information]
Harstad, E., Rosenblum, J., Gorrell, M., Achanzar, W., Minimo, L., Wu, J., Rosini-Marthaler, L., Gullo, R., Ordway, N., Kirby, M., et al (2013). DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues. Regulatory Peptides, 186, 26-35. [More Information]
Chowdhury, S., Chen, Y., Yao, T., Ajami, K., Wang, X., Popov, Y., Schuppan, D., Bertolino, P., McCaughan, G., Yu, M., Gorrell, M. (2013). Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World Journal of Gastroenterology, 19(19), 2883-2893. [More Information]
Gall, M., Chen, Y., Vieira de Ribeiro, A., Zhang, H., Bailey, C., Spielman, D., Yu, M., Gorrell, M. (2013). Targeted Inactivation of Dipeptidyl Peptidase 9 Enzymatic Activity Causes Mouse Neonate Lethality. PloS One, 8(11), 1-10. [More Information]
Akladios, F., Nadvi, N., Park, J., Hanrahan, J., Kapoor, V., Gorrell, M., Church, W. (2012). Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorganic & Medicinal Chemistry Letters, 22(4), 1579-1581. [More Information]
Yao, T., Kim, W., Yu, D., Sharbeen, G., McCaughan, G., Choi, K., Xia, P., Gorrell, M. (2011). A Novel Role of Dipeptidyl Peptidase 9 in Epidermal Growth Factor Signaling. Molecular Cancer Research, 9(7), 948-959. [More Information]
Lo, L., McLennan, S., Williams, P., Bonner, J., Chowdhury, S., McCaughan, G., Gorrell, M., Yue, D., Twigg, S. (2011). Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis. Journal of Hepatology, 55(2), 435-444. [More Information]
Song, S., Shackel, N., Wang, X., Ajami, K., McCaughan, G., Gorrell, M. (2011). Discoidin Domain Receptor 1: Isoform expression and potential functions in cirrhotic human liver. American Journal of Pathology, 178(3), 1134-1144. [More Information]
Martin, J., Deacon, C., Gorrell, M., Prins, J. (2011). Incretin-based therapies - review of the physiology, pharmacology and emerging clinical experience. Internal Medicine Journal, 41(4), 299-307. [More Information]
Keane, F., Nadvi, N., Yao, T., Gorrell, M. (2011). Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-Î±. FEBS Journal, 278(8), 1316-1332. [More Information]
Yu, M., Slaitini, L., Gysbers, V., Riekhoff, A., Kahne, T., Knott, H., De Meester, I., Abbott, C., McCaughan, G., Gorrell, M. (2011). Soluble CD26/Dipeptidyl Peptidase IV Enhances Human Lymphocyte Proliferation In Vitro Independent of Dipeptidyl Peptidase Enzyme Activity and Adenosine Deaminase Binding. Scandinavian Journal of Immunology, 73(2), 102-111. [More Information]
Gorrell, M., Zekry, A., McCaughan, G., Lloyd, A. (2011). The long and the short of interferon-gamma-inducible protein 10 in hepatitis C virus infection. Hepatology, 54(5), 1875-1879. [More Information]
Kushner, P., Gorrell, M. (2010). DPP-4 Inhibitors in Type 2 Diabetes: Importance of Selective Enzyme Inhibition and Implications for Clinical Use. Journal Of Family Practice, 59(2), 0.
Kirby, M., Yu, M., O'Connor, S., Gorrell, M. (2010). Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition. Clinical Science, 118(1), 31-41. [More Information]
Schuppan, D., Gorrell, M., Klein, T., Mark, M., Afdhal, N. (2010). The challenge of developing novel pharmacological therapies for non-alcoholic steatohepatitis. Liver International, 30(6), 795-808. [More Information]
Yu, M., Yao, T., Chowdhury, S., Nadvi, N., Osborne, B., Church, W., McCaughan, G., Gorrell, M. (2010). The dipeptidyl peptidase IV family in cancer and cell biology. FEBS Journal, 277(5), 1126-1144. [More Information]
Sharland, A., Gorrell, M. (2009). Cooperation of innate and adaptive immunity in the pathogenesis of biliary atresia: There's a killer on the run. Hepatology, 50(6), 2037-40. [More Information]
Manos, J., Arthur, J., Rose, B., Bell, S., Tingpej, P., Hu, H., Webb, J., Kjelleberg, S., Gorrell, M., Bye, P., Harbour, C. (2009). Gene expression characteristics of a cystic fibrosis epidemic strain of Pseudomonas aeruginosa during biofilm and planktonic growth. FEMS Microbiology Letters, 292(1), 107-114. [More Information]
Yu, M., Ajami, K., Gall, M., Park, J., Lee, C., Evans, K., McLaughlin, E., Pitman, M., Abbott, C., McCaughan, G., Gorrell, M. (2009). The In Vivo Expression of Dipeptidyl Peptidases 8 and 9. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, 57(11), 1025-1040. [More Information]
Devanshi, S., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2008). Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease. Journal of Hepatology, 48(4), 614-627. [More Information]
Wang, X., Yao, T., Nadvi, N., Osborne, B., McCaughan, G., Gorrell, M. (2008). Fibroblast activation protein and chronic liver disease. Frontiers in Bioscience, 13, 3168-3180. [More Information]
Gorrell, M. (2008). Impaired glucose tolerance and incretins in chronic liver disease. Journal of Gastroenterology and Hepatology, 23(2), 166-167. [More Information]
Neuman, M., Sha, K., Esguerra, R., Zakhari, S., Winkler, R., Hilzenrat, N., Wyse, J., Cooper, C., Seth, D., Gorrell, M., Haber, P., McCaughan, G., et al (2008). Inflammation and Repair in Viral Hepatitis C. Digestive Diseases and Sciences, 53(6), 1468-1487. [More Information]
Tran, D., Christiansen, D., Winterhalter, A., Brooks, A., Gorrell, M., Lilienfeld, B., Seebach, J., Sandrin, M., Sharland, A. (2008). Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D. Xenotransplantation, 15(5), 321-332. [More Information]
Park, J., Knott, H., Nadvi, N., Collyer, C., Wang, X., Church, W., Gorrell, M. (2008). Reversible Inactivation of Human Dipeptidyl Peptidases 8 and 9 by Oxidation. The Open Enzyme Inhibition Journal, 1, 52-60.
Ajami, K., Pitman, M., Wilson, C., Park, J., Menz, R., Starr, A., Cox, J., Abbott, C., Overall, C., Gorrell, M. (2008). Stromal cell-derived factors 1{alpha} and 1{beta}, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8. FEBS Letters, 582(5), 819-825. [More Information]
Manos, J., Arthur, J., Rose, B., Tingpej, P., Fung, C., Curtis, M., Webb, J., Hu, H., Kjelleberg, S., Gorrell, M., Bye, P., Harbour, C. (2008). Transcriptome analyses and biofilm-forming characteristics of a clonal Pseudomonas aeruginosa from the cystic fibrosis lung. Journal of Medical Microbiology, 57(12), 1454-1465. [More Information]
Gorrell, M., Warner, F. (2007). Fooling the liver: Malaria incognito. Hepatology, 45(3), 826-826. [More Information]
Gorrell, M. (2007). Liver fibrosis: The hepatocyte revisited. Hepatology, 46(5), 1659-61. [More Information]
Huang, X., McCaughan, G., Shackel, N., Gorrell, M. (2007). Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis. Liver International, 27(7), 960-968. [More Information]
Park, J., Ajami, K., Yu, M., Gorrell, M. (2006). Dipeptidyl peptidase 8 has post-proline dipeptidyl aminopeptidase and prolyl endopeptidase activities. Advances in Experimental Medicine and Biology, 575, 93-102. [More Information]
Yu, M., Wang, X., Ajami, K., McCaughan, G., Gorrell, M. (2006). DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration and apoptosis. Advances in Experimental Medicine and Biology, 575, 63-72. [More Information]
Wang, X., Yu, M., McCaughan, G., Gorrell, M. (2006). Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin. Advances in Experimental Medicine and Biology, 575, 213-222. [More Information]
Yu, M., Wang, X., McCaughan, G., Gorrell, M. (2006). Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis. FEBS Journal, 273(11), 2447-2460. [More Information]
Seth, D., Gorrell, M., Cordoba, S., McCaughan, G., Haber, P. (2006). Intrahepatic gene expression in human alcoholic hepatitis. Journal of Hepatology, 45(2), 306-320. [More Information]
Chen, T., Ajami, K., McCaughan, G., Gai, W., Gorrell, M., Abbott, C. (2006). Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity. Biochimica et Biophysica Acta, 1764 (1), 33-43. [More Information]
Seth, D., Beard, M., Gorrell, M., McCaughan, G., Haber, P. (2006). Osteopontin: An early marker for alcoholic liver injury? Alcoholism: Clinical and Experimental Research, 30(s2), 89A-89A.
Gorrell, M., Wang, X., Park, J., Ajami, K., Yu, M., Knott, H., Seth, D., McCaughan, G. (2006). Structure and function in dipeptidyl peptidase IV and related proteins. Advances in Experimental Medicine and Biology, 575, 45-54. [More Information]
Shackel, N., Seth, D., Haber, P., Gorrell, M., McCaughan, G. (2006). The hepatic transcriptome in human liver disease. Comparative Hepatology, 5, 6-6. [More Information]
Gorrell, M. (2005). Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders. Clinical Science, 108(4), 277-292. [More Information]
Wang, X., Yu, M., McCaughan, G., Gorrell, M. (2005). Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line. Hepatology, 42(4), 935-945. [More Information]
Ajami, K., Abbott, C., McCaughan, G., Gorrell, M. (2004). Dipeptidyl Peptidase 9 Has Two Forms, A Broad Tissue Distribution, Cytoplasmic Localization And DPIV-Like Peptidase Activity. Biochimica et Biophysica Acta, 1679 (1), 18-28. [More Information]
Cox, G., Kable, E., Jones, A., Fraser, I., Manconi, F., Gorrell, M. (2003). 3-Dimensional imaging of collagen using second harmonic generation. Journal of Structural Biology, 141(1), 53-62. [More Information]
Lorey, S., Stockel-Maschek, A., Faust, J., Brandt, W., Stiebitz, B., Gorrell, M., Kahne, T., Mrestani-Klaus, C., Wrenger, S., Reinhold, D., et al (2003). Different modes of dipetidyl pepidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites. FEBS Journal, 270(10), 2147-2156. [More Information]
Gorrell, M. (2003). First bite. Nature Structural and Molecular Biology, 10(1), 3-5. [More Information]
Seth, D., Leo, M., McGuinness, P., Lieber, C., Brennan, Y., Williams, R., Wang, X., McCaughan, G., Gorrell, M., Haber, P. (2003). Gene expression profiling of alcoholic liver disease in the Baboon (Papio hamadryas) and human liver. American Journal of Pathology, 163(6), 2303-2317. [More Information]
Shackel, N., McGuiness, P., Abbott, C., Gorrell, M., McCaughan, G. (2003). Novel differential gene expression in human cirrhosis detected by suppression substractive hybridization. Hepatology, 38(3), 577-588. [More Information]
Haber, P., Warner, R., Seth, D., Gorrell, M., McCaughan, G. (2003). Pathogenesis and management of alcoholic hepatitis. Journal of Gastroenterology and Hepatology, 18(12), 1332-1344. [More Information]
Seth, D., Gorrell, M., McGuiness, P., Leo, M., Lieber, C., McCaughan, G., Haber, P. (2003). SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates. Journal Of Biochemical and Biophysical Methods, 55(1), 53-66. [More Information]
Ajami, K., Abbott, C., Obradovic, M., Gysbers, V., Kahne, T., McCaughan, G., Gorrell, M. (2003). Structural requirements for catalysis, expression, dimerization in the CD26/DPIV gene family. Biochemistry, 42(3), 694-701. [More Information]
Shackel, N., Gorrell, M., McCaughan, G. (2002). Gene array analysis and the liver. Hepatology, 36(6), 1313-1325. [More Information]
Wang, M., Gorrell, M., Abbott, C., Jaggi, R., Marguet, D., Dickinson, R. (2002). Hepatic covalent adduct formation with zomepirac in the CD26-deficient mouse. Journal of Gastroenterology and Hepatology, 17(1), 66-71. [More Information]
Shackel, N., McGuinness, P., Abbott, C., Gorrell, M., McCaughan, G. (2002). Insights into the pathobiology of hepatitis C virus-associated cirrhosis. American Journal of Pathology, 160(2), 641-654. [More Information]
Levy, M., McCaughan, G., Marinos, G., Gorrell, M. (2002). Intrahepatic expression of the hepatic stellate cell marker fibroblast activation protein correlates with the degree of fibrosis in hepatitis C virus infection. Liver International, 22(2), 93-101. [More Information]
McCaughan, G., Gorrell, M., Bishop, A., Abbott, C., Shackel, N., McGuinness, P., Levy, M., Sharland, A., Bowen, D., Yu, M., Slaitini, L., Napoli, J., et al (2000). Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunological Reviews, 174(1), 172-191. [More Information]

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Conferences

Banavar, M., Kable, E., Braet, F., Wang, X., Gorrell, M., Cox, G. (2006). Detection of Collagen by Second Harmonic Microscopy as a Diagnostic Tool for Liver Fibrosis. Multiphoton Microscopy in the Biomedical Sciences VI, Bellingham, Washington, USA: SPIE - International Society for Optical Engineering. [More Information]
Seth, D., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2006). Identification of novel therapeutic targets for alcoholic liver disease. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
Wang, X., Yu, D., Schnapp, A., Marguet, D., Cordoba, S., Retting, W., McCaughan, G., Gorrell, M. (2005). The role of fibroblast activation protein (FAP) in cell adhesion, migration and liver fibrosis. 56th Annual Meeting of the American Association for the Study of Liver Diseases, United States: John Wiley & Sons.

Patents

Abbott, C., Gorrell, M. (2011). Dipeptidyl Peptidases (Dpp8) (Japan). Patent No. 4748908.
Abbott, C., Gorrell, M. (2011). Dipeptidyl Peptidases (Dpp9) (USA). Patent No. 7888094.
Gorrell, M., Abbott, C. (2010). Nucleic Acid Molecules Encoding Prolyl Dipeptidyl Peptidases [Dipeptidyl Peptidases (Dpp9)]. Patent No. 7662944.
Abbott, C., Gorrell, M. (2007). Dipeptidyl Peptidases (Dpp9). Patent No. 1337629, 7276365. , Austria, Belgium, Cyprus, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Monaco, Netherlands, Portugal, Spain, Sweden, Switzerland, Turkey, United Kingdom.
Abbott, C., Gorrell, M. (2006). Dipeptidyl Peptidases (Dpp8). Patent No. 1214344, 7148338. , Austria, Belgium, Cyprus, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Monaco, Netherlands, Portugal, Spain, Sweden, Switzerland, United Kingdom.
Abbott, C., Gorrell, M. (2006). Patent No. 7148338.

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By Year

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2025

Ly, M., Lau, N., Dennis, C., Chen, J., Risbey, C., Tan, S., Chen, R., Wang, C., Gorrell, M., McKenzie, C., Kench, J., Liu, K., McCaughan, G., Crawford, M., Pulitano, C. (2025). Long Term Ex-Situ Normothermic Machine Perfusion Allows Regeneration of Human Livers with Severe Bile Duct Injury. American Journal Of Transplantation, 25(1), 60-71. [More Information]

2024

Hargett, S., Shrestha, R., Janitz, M., Gorrell, M., Bruce, C., Wilkins, M., Hoehn, K., Byrne, F., Lahiri, S., Kowalski, G., et al (2024). Bile acids mediate fructose-associated liver tumour growth in mice. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870 (3), 167029. [More Information]
Liu, X., Huang, Y., Liu, D., Jiang, Y., Zhao, M., Chung, L., Han, X., Zhao, Y., Chen, J., Coleman, P., Ting, K., Tran, C., Su, Y., Don, A., Vadas, M., Gorrell, M., Murray, M., Kavurma, M., McCaughan, G., Gamble, J., Qi, Y., et al (2024). Targeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis. Journal of Translational Medicine, 22(1), 43. [More Information]

2022

Liu, X., Chung, L., Liu, D., Chen, J., Huang, Y., Teo, J., Han, X., Zhao, Y., Guan, F., Tran, C., Lee, J., Couttas, T., McCaughan, G., Gorrell, M., Don, A., Qi, Y., et al (2022). Ablation of sphingosine kinase 2 suppresses fatty liver- associated hepatocellular carcinoma via downregulation of ceramide transfer protein. Oncogenesis, 11(1), 1-12. [More Information]
Jaenisch, S., Abbott, C., Gorrell, M., Bampton, P., Butler, R., Yazbeck, R. (2022). Circulating Dipeptidyl Peptidase Activity Is a Potential Biomarker for Inflammatory Bowel Disease. Clinical and Translational Gastroenterology, 13(1), E00452. [More Information]
Bolgi, O., Weiss, K., Donzelli, L., Gorrell, M., Grade, M., Riemer, J., Urlaub, H., Dobbelstein, M., Huber, R., Geiss-Friedlander, R., et al (2022). Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair. EMBO Reports, 23(10), e54136. [More Information]
Harapas, C., Robinson, K., Lay, K., Wong, J., Traspas, R., Nabavizadeh, N., Rass-Rothschild, A., Boisson, B., Drutman, S., Laohamonthonkul, P., Gorrell, M., et al (2022). DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling. Science Immunology, 7(75). [More Information]
Ren, J., Wang, X., Yee, C., Gorrell, M., McLennan, S., Twigg, S. (2022). Sitagliptin Is More Effective Than Gliclazide in Preventing Pro-Fibrotic and Pro-Inflammatory Changes in a Rodent Model of Diet-Induced Non-Alcoholic Fatty Liver Disease. Molecules, 27(3), 727. [More Information]
Ren, J., Wang, X., Parry, S., Yee, C., Gorrell, M., McLennan, S., Twigg, S. (2022). Targeting CCN2 protects against progressive non-alcoholic steatohepatitis in a preclinical model induced by high-fat feeding and type 2 diabetes. Journal of Cell Communication and Signaling, 16(3), 447-460. [More Information]

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2021

Xi, C., Di Fazio, A., Nadvi, N., Xiang, M., Zhang, H., Deshpande, C., Chen, Y., Sharifi Tabar, M., Wang, X., Bailey, C., McCaughan, G., Church, W., Gorrell, M. (2021). An improved production and purification protocol for recombinant soluble human fibroblast activation protein alpha. Protein Expression and Purification, 181, 1-8. [More Information]
Stein, S., Weber, J., Nusser-Stein, S., Pahla, J., Zhang, H., Mohammed, S., Oppi, S., Gaul, D., Paneni, F., Tailleux, A., et al (2021). Deletion of fibroblast activation protein provides atheroprotection. Cardiovascular Research, 117(4), 1060-1069. [More Information]
Chen, H., Li, G., Chan, Y., Zhang, H., Gorrell, M., Pollock, C., Saad, S., Oliver, B. (2021). Differential Effects of Vaping' on Lipid and Glucose Profiles and Liver Metabolic Markers in Obese Versus Non-obese Mice. Frontiers in Physiology, 12, 755124. [More Information]
Henderson, J., Xiang, M., Huang, C., Wetzel, S., Jiang, L., Lai, J., Wu, W., Kench, J., Bachovchin, W., Roediger, B., McCaughan, G., Zhang, H., Gorrell, M. (2021). Dipeptidyl peptidase inhibition enhances cd8 t cell recruitment and activates intrahepatic inflammasome in a murine model of hepatocellular carcinoma. Cancers, 13(21), 5495. [More Information]
Wilson, A., Moffitt, L., Wilson, K., Bilandzic, M., Wright, M., Gorrell, M., Oehler, M., Plebanski, M., Stephens, A. (2021). DPP4 inhibitor sitagliptin enhances lymphocyte recruitment and prolongs survival in a syngeneic ovarian cancer mouse model. Cancers, 13(3), 1-18. [More Information]
Huang, C., Emran, A., Endaya, J., McCaughan, G., Gorrell, M., Zhang, H. (2021). Dpp9: Comprehensive in silico analyses of loss of function gene variants and associated gene expression signatures in human hepatocellular carcinoma. Cancers, 13(7), 1637-1-1637-18. [More Information]

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2020

Xi, C., Di Fazio, A., Nadvi, N., Patel, K., Xiang, M., Zhang, H., Deshpande, C., Low, J., Chen, Y., McMillan, C., Osborne, B., Vieira de Ribeiro, A., McCaughan, G., Mackay, J., Church, W., Gorrell, M., et al (2020). A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2. Molecules, 25(22). [More Information]
Johansen, M., Irving, A., Montagutelli, X., Tate, M., Rudloff, I., Nold, M., Hansbro, N., Kim, R., Donovan, C., Liu, G., McCaughan, G., Gorrell, M., Cole, A., Moreno, C., Le Couteur, D., Hesselson, D., Triccas, J., Neely, G., Gamble, J., Simpson, S., et al (2020). Animal and translational models of SARS-CoV-2 infection and COVID-19. Mucosal Immunology, 13(6), 877-891. [More Information]
Bassendine, M., Bridge, S., McCaughan, G., Gorrell, M. (2020). Covid-19 and co-morbidities: a role for Dipeptidyl Peptidase 4 (DPP4) in disease severity? Journal of Diabetes, 12(9), 649-658. [More Information]
Moffitt, L., Bilandzic, M., Wilson, A., Chen, Y., Gorrell, M., Oehler, M., Plebanski, M., Stephens, A. (2020). Hypoxia regulates dpp4 expression, proteolytic inactivation, and shedding from ovarian cancer cells. International Journal of Molecular Sciences, 21(21), 1-14. [More Information]

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2019

Zhang, H., Henderson, J., Gorrell, M. (2019). Animal models for hepatocellular carcinoma. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1865 (5), 993-1002. [More Information]
Lay, A., Zhang, H., McCaughan, G., Gorrell, M. (2019). Fibroblast activation protein in liver fibrosis. Frontiers in Bioscience, 24, 1-17. [More Information]
Zhang, H., Hamson, E., Koczorowska, M., Tholen, S., Chowdhury, S., Bailey, C., Lay, A., Twigg, S., Lee, Q., Roediger, B., O'Rourke, M., McCaughan, G., Keane, F., Gorrell, M., et al (2019). Identification of novel natural substrates of fibroblast activation protein-alpha by differential degradomics and proteomics. Molecular and Cellular Proteomics, 18(1), 65-85. [More Information]
Gall, M., Zhang, H., Lee, Q., Jolly, C., McCaughan, G., Cook, A., Roediger, B., Gorrell, M. (2019). Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity. Scientific Reports, 9(1), 1-10. [More Information]
Wilson, A., Wilson, K., Bilandzic, M., Moffitt, L., Makanji, M., Gorrell, M., Oehler, M., Rainczuk, A., Stephens, A., Plebanski, M. (2019). Non-Invasive Fluorescent Monitoring of Ovarian Cancer in an Immunocompetent Mouse Model. Cancers, 11(1), 1-19. [More Information]

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2018

Roediger, B., Lee, Q., Tikoo, S., Cobbin, J., Henderson, J., Jormakka, M., O'Rourke, M., Padula, M., Pinello, N., Henry, M., Wynne, M., Lisowski, L., Tay, S., Harris, D., Bertolino, P., Wong, J., Gorrell, M., Holmes, E., Jolly, C., Weninger, W., et al (2018). An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis. Cell, 175(2), 530-540. [More Information]
Zhang, H., Brewer, K., Jeffrey, G., Twigg, S., McGaughan, G., Williams, K., Adams, L., Gorrell, M. (2018). Circulating Fibroblast Activation Protein activity as a liver fibrosis biomarker in NAFLD. Journal of Hepatology, 66(1), S666-S667. [More Information]
Sinnathura, P., Lau, W., Vieira de Ribeiro, A., Bachovchin, W., Englert, H., Howe, G., Spencer, D., Manolios, N., Gorrell, M. (2018). Circulating fibroblast activation protein and dipeptidyl peptidase 4 in rheumatoid arthritis and systemic sclerosis. International Journal of Rheumatic Diseases, 21(11), 1915-1923. [More Information]
Cook, S., Lee, Q., Wong, A., Spann, B., Vincent, J., Wong, J., Schlitzer, A., Gorrell, M., Weninger, W., Roediger, B. (2018). Differential chemokine receptor expression and usage by pre-cDC1 and pre-cDC2. Immunology and Cell Biology, 96(10), 1131-1139. [More Information]
Gorrell, M., Zhang, H. (2018). Dipeptidyl Peptidase 8. Encyclopedia of Signaling Molecules - 2nd Edition, (pp. 1414-1417). Cham: Springer International Publishing. [More Information]
Zhang, H., Gorrell, M. (2018). Dipeptidyl Peptidase 9. Encyclopedia of Signaling Molecules - 2nd Edition, (pp. 1418-1422). Cham: Springer International Publishing. [More Information]
Polak, N., Gorrell, M. (2018). Fibroblast activation protein. Encyclopedia of Signaling Molecules - 2nd Edition, (pp. 1676-1681). Cham: Springer International Publishing. [More Information]
Zhang, H., Gall, M., Gorrell, M. (2018). Letter to Editor. Developmental Biology, 439(1), 1. [More Information]
Henderson, J., Polak, N., Chen, J., Roediger, B., Weninger, W., Kench, J., McCaughan, G., Zhang, H., Gorrell, M. (2018). Multiple liver insults synergize to accelerate experimental hepatocellular carcinoma. Scientific Reports, 8(1), 1-12. [More Information]

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2017

De Willige, S., Keane, F., Bowen, D., Malfliet, J., Zhang, H., Maneck, B., McCaughan, G., Leebeek, F., Rijken, D., Gorrell, M. (2017). Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease. PloS One, 12(6), 1-8. [More Information]
Tan, S., Chowdhury, S., Polak, N., Gorrell, M., Weninger, W. (2017). Fibroblast activation protein is dispensable in the anti-influenza immune response in mice. PloS One, 12(2), 1-15. [More Information]
Henderson, J., Zhang, H., Polak, N., Gorrell, M. (2017). Hepatocellular carcinoma: Mouse models and the potential roles of proteases. Cancer Letters, 387, 106-113. [More Information]
Nadvi, N., Salam, N., Park, J., Akladios, F., Kapoor, V., Collyer, C., Gorrell, M., Church, W. (2017). High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate. Protein Science, 26(4), 727-736. [More Information]
Jayawickrama, G., Nematollahi, A., Sun, G., Gorrell, M., Church, W. (2017). Inhibition of human kynurenine aminotransferase isozymes by estrogen and its derivatives. Scientific Reports, 7(1), 1-11. [More Information]
Gall, M., Gorrell, M. (2017). The Multifunctional Post-proline Dipeptidyl Peptidase, DPP9, in Mice, Cell Biology and Immunity. In Sajal Chakraborti and Naranjan S. Dhalla (Eds.), Pathophysiological Aspects of Proteases, (pp. 23-45). Singapore: Springer. [More Information]
Wang, X., Holz, L., Chowdhury, S., Cordoba, S., Evans, K., Gall, M., Vieira de Ribeiro, A., Zheng, Y., Levy, M., Yu, M., Yao, T., Polak, N., Jolly, C., Bertolino, P., McCaughan, G., Gorrell, M. (2017). The pro-fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride-induced experimental liver injury. Immunology and Cell Biology, 95(5), 443-453. [More Information]

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2016

Chen, Y., Gall, M., Zhang, H., Keane, F., McCaughan, G., Yu, M., Gorrell, M. (2016). Dipeptidyl peptidase 9 enzymatic activity influences the expression of neonatal metabolic genes. Experimental Cell Research, 342(1), 72-82. [More Information]
Wilson, C., Zhang, H., Gorrell, M., Abbott, C. (2016). Dipeptidyl peptidase 9 substrates and their discovery: Current progress and the application of mass spectrometry-based approaches. Biological Chemistry, 397(9), 837-856. [More Information]
Wong, P., Gall, M., Bachovchin, W., McCaughan, G., Keane, F., Gorrell, M. (2016). Neuropeptide Y is a physiological substrate of fibroblast activation protein: Enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver cirrhosis and hepatocellular carcinoma. Peptides, 75, 80-95. [More Information]

2015

Williams, K., Vieira de Ribeiro, A., Prakoso, E., Veillard, A., Shackel, N., Brooks, B., Bu, Y., Cavanagh, E., Raleigh, J., McLennan, S., McCaughan, G., Keane, F., Gorrell, M., Twigg, S., et al (2015). Circulating Dipeptidyl Peptidase-4 Activity Correlates with Measures of Hepatocyte Apoptosis and Fibrosis in NAFLD in Type 2 Diabetes Mellitus and Obesity: A Dual Cohort Cross-Sectional Study. Journal of Diabetes, 7(6), 809-819. [More Information]
Zhang, H., Chen, Y., Wadham, C., McCaughan, G., Keane, F., Gorrell, M. (2015). Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin. Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, 1853 (2), 470-480. [More Information]
Zhang, H., Maqsudi, S., Rainczuk, A., Duffield, N., Lawrence, J., Keane, F., Justa-Schuch, D., Geiss-Friedlander, R., Gorrell, M., Stephens, A. (2015). Identification of novel dipeptidyl peptidase 9 substrates by two-dimensional differential in-gel electrophoresis. FEBS Journal, 282(19), 3737-3757. [More Information]
Jayawickrama, G., Sadig, R., Sun, G., Nematollahi, A., Nadvi, N., Hanrahan, J., Gorrell, M., Church, W. (2015). Kynurenine aminotransferases and the prospects of inhibitors for the treatment of schizophrenia. Current Medicinal Chemistry, 22(24), 2902-2918. [More Information]
Williams, K., Vieira de Ribeiro, A., Prakoso, E., Veillard, A., Shackel, N., Bu, Y., Brooks, B., Cavanagh, E., Raleigh, J., McLennan, S., McCaughan, G., Keane, F., Twigg, S., Gorrell, M., et al (2015). Lower serum fibroblast activation protein shows promise in the exclusion of clinically significant liver fibrosis due to non-alcoholic fatty liver disease in diabetes and obesity. Diabetes Research and Clinical Practice, 108(3), 466-472. [More Information]

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2014

Osborne, B., Yao, T., Wang, X., Chen, Y., Kotan, L., Nadvi, N., Herdem, M., McCaughan, G., Allen, J., Yu, M., Gorrell, M., et al (2014). A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation. Biochimica et Biophysica Acta. Proteins and Proteomics, 1844 (7), 1248-1259. [More Information]
Nematollahi, A., Church, W., Nadvi, N., Gorrell, M., Sun, G. (2014). Homology Modeling of Human Kynurenine Aminotransferase III and Observations on Inhibitor Binding Using Molecular Docking. Central Nervous System Agents in Medicinal Chemistry, 14(1), 2-9. [More Information]
Keane, F., Yao, T., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y., Wu, W., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, M., Seth, D., Haber, P., Wang, C., Thomson, S., Twigg, S., McLennan, S., McCaughan, G., Gorrell, M., et al (2014). Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs. FEBS Open Bio, 4, 43-54. [More Information]
Hamson, E., Keane, F., Tholen, S., Schilling, O., Gorrell, M. (2014). Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy. Proteomics - Clinical Applications, 8, 454-463. [More Information]

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2013

Zhang, H., Chen, Y., Keane, F., Gorrell, M. (2013). Advances in Understanding the Expression and Function of Dipeptidyl Peptidase 8 and 9. Molecular Cancer Research, 11(12), 1487-1496. [More Information]
Williams, K., Shackel, N., Gorrell, M., McLennan, S., Twigg, S. (2013). Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo. Endocrine Reviews, 34(1), 84-129. [More Information]
Abbott, C., Gorrell, M. (2013). Dipeptidyl Peptidase 8. In Neil D. Rawlings, Guy Salvesen (Eds.), Handbook of Proteolytic Enzymes: Volume 3, (pp. 3379-3384). London, United Kingdom: Elsevier. [More Information]
Harstad, E., Rosenblum, J., Gorrell, M., Achanzar, W., Minimo, L., Wu, J., Rosini-Marthaler, L., Gullo, R., Ordway, N., Kirby, M., et al (2013). DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues. Regulatory Peptides, 186, 26-35. [More Information]
Gorrell, M., Park, J. (2013). Fibroblast Activation Protein alpha. In Neil D. Rawlings, Guy Salvesen (Eds.), Handbook of Proteolytic Enzymes: Volume 3, (pp. 3395-3401). London, United Kingdom: Elsevier. [More Information]
Chowdhury, S., Chen, Y., Yao, T., Ajami, K., Wang, X., Popov, Y., Schuppan, D., Bertolino, P., McCaughan, G., Yu, M., Gorrell, M. (2013). Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World Journal of Gastroenterology, 19(19), 2883-2893. [More Information]
Gall, M., Chen, Y., Vieira de Ribeiro, A., Zhang, H., Bailey, C., Spielman, D., Yu, M., Gorrell, M. (2013). Targeted Inactivation of Dipeptidyl Peptidase 9 Enzymatic Activity Causes Mouse Neonate Lethality. PloS One, 8(11), 1-10. [More Information]

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2012

Akladios, F., Nadvi, N., Park, J., Hanrahan, J., Kapoor, V., Gorrell, M., Church, W. (2012). Design and synthesis of novel inhibitors of human kynurenine aminotransferase-I. Bioorganic & Medicinal Chemistry Letters, 22(4), 1579-1581. [More Information]
Keane, F., Chowdhury, S., Yao, T., Nadvi, N., Gall, M., Chen, Y., Osborne, B., Ribeiro, A., Church, W., McCaughan, G., Gorrell, M., Yu, M. (2012). Targeting Dipeptidyl Peptidase-4 (DPP-4) and Fibroblast Activation Protein (FAP) for Diabetes and Cancer Therapy. In Ben Dunn (Eds.), Proteinases as Drug Targets, (pp. 118-144). Cambridge, UK: RSC Publishing. [More Information]

2011

Yao, T., Kim, W., Yu, D., Sharbeen, G., McCaughan, G., Choi, K., Xia, P., Gorrell, M. (2011). A Novel Role of Dipeptidyl Peptidase 9 in Epidermal Growth Factor Signaling. Molecular Cancer Research, 9(7), 948-959. [More Information]
Lo, L., McLennan, S., Williams, P., Bonner, J., Chowdhury, S., McCaughan, G., Gorrell, M., Yue, D., Twigg, S. (2011). Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis. Journal of Hepatology, 55(2), 435-444. [More Information]
Abbott, C., Gorrell, M. (2011). Dipeptidyl Peptidases (Dpp8) (Japan). Patent No. 4748908.
Abbott, C., Gorrell, M. (2011). Dipeptidyl Peptidases (Dpp9) (USA). Patent No. 7888094.
Song, S., Shackel, N., Wang, X., Ajami, K., McCaughan, G., Gorrell, M. (2011). Discoidin Domain Receptor 1: Isoform expression and potential functions in cirrhotic human liver. American Journal of Pathology, 178(3), 1134-1144. [More Information]
Martin, J., Deacon, C., Gorrell, M., Prins, J. (2011). Incretin-based therapies - review of the physiology, pharmacology and emerging clinical experience. Internal Medicine Journal, 41(4), 299-307. [More Information]
Keane, F., Nadvi, N., Yao, T., Gorrell, M. (2011). Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-Î±. FEBS Journal, 278(8), 1316-1332. [More Information]
Yu, M., Slaitini, L., Gysbers, V., Riekhoff, A., Kahne, T., Knott, H., De Meester, I., Abbott, C., McCaughan, G., Gorrell, M. (2011). Soluble CD26/Dipeptidyl Peptidase IV Enhances Human Lymphocyte Proliferation In Vitro Independent of Dipeptidyl Peptidase Enzyme Activity and Adenosine Deaminase Binding. Scandinavian Journal of Immunology, 73(2), 102-111. [More Information]
Gorrell, M., Zekry, A., McCaughan, G., Lloyd, A. (2011). The long and the short of interferon-gamma-inducible protein 10 in hepatitis C virus infection. Hepatology, 54(5), 1875-1879. [More Information]

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2010

Kushner, P., Gorrell, M. (2010). DPP-4 Inhibitors in Type 2 Diabetes: Importance of Selective Enzyme Inhibition and Implications for Clinical Use. Journal Of Family Practice, 59(2), 0.
Kirby, M., Yu, M., O'Connor, S., Gorrell, M. (2010). Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition. Clinical Science, 118(1), 31-41. [More Information]
Gorrell, M., Abbott, C. (2010). Nucleic Acid Molecules Encoding Prolyl Dipeptidyl Peptidases [Dipeptidyl Peptidases (Dpp9)]. Patent No. 7662944.
Schuppan, D., Gorrell, M., Klein, T., Mark, M., Afdhal, N. (2010). The challenge of developing novel pharmacological therapies for non-alcoholic steatohepatitis. Liver International, 30(6), 795-808. [More Information]
Yu, M., Yao, T., Chowdhury, S., Nadvi, N., Osborne, B., Church, W., McCaughan, G., Gorrell, M. (2010). The dipeptidyl peptidase IV family in cancer and cell biology. FEBS Journal, 277(5), 1126-1144. [More Information]

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2009

Sharland, A., Gorrell, M. (2009). Cooperation of innate and adaptive immunity in the pathogenesis of biliary atresia: There's a killer on the run. Hepatology, 50(6), 2037-40. [More Information]
Manos, J., Arthur, J., Rose, B., Bell, S., Tingpej, P., Hu, H., Webb, J., Kjelleberg, S., Gorrell, M., Bye, P., Harbour, C. (2009). Gene expression characteristics of a cystic fibrosis epidemic strain of Pseudomonas aeruginosa during biofilm and planktonic growth. FEMS Microbiology Letters, 292(1), 107-114. [More Information]
Yu, M., Ajami, K., Gall, M., Park, J., Lee, C., Evans, K., McLaughlin, E., Pitman, M., Abbott, C., McCaughan, G., Gorrell, M. (2009). The In Vivo Expression of Dipeptidyl Peptidases 8 and 9. Journal of Histochemistry and Cytochemistry: imaging the spectrum of cell biology, 57(11), 1025-1040. [More Information]

2008

Devanshi, S., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2008). Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease. Journal of Hepatology, 48(4), 614-627. [More Information]
Wang, X., Yao, T., Nadvi, N., Osborne, B., McCaughan, G., Gorrell, M. (2008). Fibroblast activation protein and chronic liver disease. Frontiers in Bioscience, 13, 3168-3180. [More Information]
Gorrell, M. (2008). Impaired glucose tolerance and incretins in chronic liver disease. Journal of Gastroenterology and Hepatology, 23(2), 166-167. [More Information]
Neuman, M., Sha, K., Esguerra, R., Zakhari, S., Winkler, R., Hilzenrat, N., Wyse, J., Cooper, C., Seth, D., Gorrell, M., Haber, P., McCaughan, G., et al (2008). Inflammation and Repair in Viral Hepatitis C. Digestive Diseases and Sciences, 53(6), 1468-1487. [More Information]
Tran, D., Christiansen, D., Winterhalter, A., Brooks, A., Gorrell, M., Lilienfeld, B., Seebach, J., Sandrin, M., Sharland, A. (2008). Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D. Xenotransplantation, 15(5), 321-332. [More Information]
Park, J., Knott, H., Nadvi, N., Collyer, C., Wang, X., Church, W., Gorrell, M. (2008). Reversible Inactivation of Human Dipeptidyl Peptidases 8 and 9 by Oxidation. The Open Enzyme Inhibition Journal, 1, 52-60.
Ajami, K., Pitman, M., Wilson, C., Park, J., Menz, R., Starr, A., Cox, J., Abbott, C., Overall, C., Gorrell, M. (2008). Stromal cell-derived factors 1{alpha} and 1{beta}, inflammatory protein-10 and interferon-inducible T cell chemo-attractant are novel substrates of dipeptidyl peptidase 8. FEBS Letters, 582(5), 819-825. [More Information]
Manos, J., Arthur, J., Rose, B., Tingpej, P., Fung, C., Curtis, M., Webb, J., Hu, H., Kjelleberg, S., Gorrell, M., Bye, P., Harbour, C. (2008). Transcriptome analyses and biofilm-forming characteristics of a clonal Pseudomonas aeruginosa from the cystic fibrosis lung. Journal of Medical Microbiology, 57(12), 1454-1465. [More Information]

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2007

Abbott, C., Gorrell, M. (2007). Dipeptidyl Peptidases (Dpp9). Patent No. 1337629, 7276365. , Austria, Belgium, Cyprus, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Monaco, Netherlands, Portugal, Spain, Sweden, Switzerland, Turkey, United Kingdom.
Gorrell, M., Warner, F. (2007). Fooling the liver: Malaria incognito. Hepatology, 45(3), 826-826. [More Information]
McCaughan, G., Shackel, N., Williams, R., Seth, D., Haber, P., Gorrell, M. (2007). Genomics, gene arrays and proteomics in the study of liver disease. In Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, and Mario Rizzetto (Eds.), The Textbook of Hepatology: From Basic Science to Clinical Practice, (pp. 398-420). USA: Blackwell Publishers. [More Information]
Gorrell, M. (2007). Liver fibrosis: The hepatocyte revisited. Hepatology, 46(5), 1659-61. [More Information]
Huang, X., McCaughan, G., Shackel, N., Gorrell, M. (2007). Up-regulation of proproliferative genes and the ligand/receptor pair placental growth factor and vascular endothelial growth factor receptor 1 in hepatitis C cirrhosis. Liver International, 27(7), 960-968. [More Information]

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2006

Banavar, M., Kable, E., Braet, F., Wang, X., Gorrell, M., Cox, G. (2006). Detection of Collagen by Second Harmonic Microscopy as a Diagnostic Tool for Liver Fibrosis. Multiphoton Microscopy in the Biomedical Sciences VI, Bellingham, Washington, USA: SPIE - International Society for Optical Engineering. [More Information]
Park, J., Ajami, K., Yu, M., Gorrell, M. (2006). Dipeptidyl peptidase 8 has post-proline dipeptidyl aminopeptidase and prolyl endopeptidase activities. Advances in Experimental Medicine and Biology, 575, 93-102. [More Information]
Abbott, C., Gorrell, M. (2006). Dipeptidyl Peptidases (Dpp8). Patent No. 1214344, 7148338. , Austria, Belgium, Cyprus, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Monaco, Netherlands, Portugal, Spain, Sweden, Switzerland, United Kingdom.
Yu, M., Wang, X., Ajami, K., McCaughan, G., Gorrell, M. (2006). DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration and apoptosis. Advances in Experimental Medicine and Biology, 575, 63-72. [More Information]
Wang, X., Yu, M., McCaughan, G., Gorrell, M. (2006). Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin. Advances in Experimental Medicine and Biology, 575, 213-222. [More Information]
Yu, M., Wang, X., McCaughan, G., Gorrell, M. (2006). Extraenzymatic functions of the dipeptidyl peptidase IV-related proteins DP8 and DP9 in cell adhesion, migration and apoptosis. FEBS Journal, 273(11), 2447-2460. [More Information]
Seth, D., Hogg, P., Gorrell, M., McCaughan, G., Haber, P. (2006). Identification of novel therapeutic targets for alcoholic liver disease. International Society for Biomedical Research on Alcoholism World congress on Alcohol Research (ISBRA 2006), Maryland: Wiley-Blackwell Publishing.
Seth, D., Gorrell, M., Cordoba, S., McCaughan, G., Haber, P. (2006). Intrahepatic gene expression in human alcoholic hepatitis. Journal of Hepatology, 45(2), 306-320. [More Information]
Chen, T., Ajami, K., McCaughan, G., Gai, W., Gorrell, M., Abbott, C. (2006). Molecular characterization of a novel dipeptidyl peptidase like 2-short form (DPL2-s) that is highly expressed in the brain and lacks dipeptidyl peptidase activity. Biochimica et Biophysica Acta, 1764 (1), 33-43. [More Information]
Abbott, C., Gorrell, M. (2006). Patent No. 7148338.
Seth, D., Beard, M., Gorrell, M., McCaughan, G., Haber, P. (2006). Osteopontin: An early marker for alcoholic liver injury? Alcoholism: Clinical and Experimental Research, 30(s2), 89A-89A.
Gorrell, M., Wang, X., Park, J., Ajami, K., Yu, M., Knott, H., Seth, D., McCaughan, G. (2006). Structure and function in dipeptidyl peptidase IV and related proteins. Advances in Experimental Medicine and Biology, 575, 45-54. [More Information]
Shackel, N., Seth, D., Haber, P., Gorrell, M., McCaughan, G. (2006). The hepatic transcriptome in human liver disease. Comparative Hepatology, 5, 6-6. [More Information]

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2005

Gorrell, M. (2005). Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders. Clinical Science, 108(4), 277-292. [More Information]
Gorrell, M., Yu, M. (2005). Diverse functions in a conserved structure: The dipeptidyl peptidase IV gene family. In Robinson J (Eds.), Trends in Protein Research, (pp. 1-78). New York: Nova Biomedical Books.
Wang, X., Yu, M., McCaughan, G., Gorrell, M. (2005). Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line. Hepatology, 42(4), 935-945. [More Information]
Wang, X., Yu, D., Schnapp, A., Marguet, D., Cordoba, S., Retting, W., McCaughan, G., Gorrell, M. (2005). The role of fibroblast activation protein (FAP) in cell adhesion, migration and liver fibrosis. 56th Annual Meeting of the American Association for the Study of Liver Diseases, United States: John Wiley & Sons.

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2004

Ajami, K., Abbott, C., McCaughan, G., Gorrell, M. (2004). Dipeptidyl Peptidase 9 Has Two Forms, A Broad Tissue Distribution, Cytoplasmic Localization And DPIV-Like Peptidase Activity. Biochimica et Biophysica Acta, 1679 (1), 18-28. [More Information]

2003

Cox, G., Kable, E., Jones, A., Fraser, I., Manconi, F., Gorrell, M. (2003). 3-Dimensional imaging of collagen using second harmonic generation. Journal of Structural Biology, 141(1), 53-62. [More Information]
Stockel-Maschek, A., Stiebitz, B., Faust, J., Born, I., Kahne, T., Gorrell, M., Neubert, K. (2003). Different inhibition mechanisms of dipeptidyl peptidaseIV by tryptophan containing peptides and amides. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 69-72). NY: Springer.
Lorey, S., Stockel-Maschek, A., Faust, J., Brandt, W., Stiebitz, B., Gorrell, M., Kahne, T., Mrestani-Klaus, C., Wrenger, S., Reinhold, D., et al (2003). Different modes of dipetidyl pepidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites. FEBS Journal, 270(10), 2147-2156. [More Information]
Chen, T., Ajami, K., McCaughan, G., Gorrell, M., Abbott, C. (2003). Dipeptidyl peptidase IV gene family. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 79-88). NY: Springer.
Gorrell, M. (2003). First bite. Nature Structural and Molecular Biology, 10(1), 3-5. [More Information]
Seth, D., Leo, M., McGuinness, P., Lieber, C., Brennan, Y., Williams, R., Wang, X., McCaughan, G., Gorrell, M., Haber, P. (2003). Gene expression profiling of alcoholic liver disease in the Baboon (Papio hamadryas) and human liver. American Journal of Pathology, 163(6), 2303-2317. [More Information]
Gorrell, M., Wang, X., Levy, M., Kable, E., Marinos, G., Cox, G., McCaughan, G. (2003). Intrahepatic expression of collagen and fibroblast activation protein (FAP) in hepatitis C virus infection. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 235-243). NY: Springer.
Ajami, K., Abbott, C., Gysbers, V., Kaehne, T., McCaughan, G., Gorrell, M. (2003). Molecular chimeras and mutational analysis in the prolyl oligopeptidase gene family. In M. Hildebrandt, B. F. Klapp, T. Hoffman and H.-U. Demuth (Eds.), Dipeptidyl Aminopeptidases in Health and Disease, (pp. 49-55). NY: Springer.
Shackel, N., McGuiness, P., Abbott, C., Gorrell, M., McCaughan, G. (2003). Novel differential gene expression in human cirrhosis detected by suppression substractive hybridization. Hepatology, 38(3), 577-588. [More Information]
Haber, P., Warner, R., Seth, D., Gorrell, M., McCaughan, G. (2003). Pathogenesis and management of alcoholic hepatitis. Journal of Gastroenterology and Hepatology, 18(12), 1332-1344. [More Information]
Seth, D., Gorrell, M., McGuiness, P., Leo, M., Lieber, C., McCaughan, G., Haber, P. (2003). SMART amplification maintains representation of relative gene expression: quantitative validation by real time PCR and application to studies of alcoholic liver disease in primates. Journal Of Biochemical and Biophysical Methods, 55(1), 53-66. [More Information]
Ajami, K., Abbott, C., Obradovic, M., Gysbers, V., Kahne, T., McCaughan, G., Gorrell, M. (2003). Structural requirements for catalysis, expression, dimerization in the CD26/DPIV gene family. Biochemistry, 42(3), 694-701. [More Information]

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2002

Shackel, N., Gorrell, M., McCaughan, G. (2002). Gene array analysis and the liver. Hepatology, 36(6), 1313-1325. [More Information]
Wang, M., Gorrell, M., Abbott, C., Jaggi, R., Marguet, D., Dickinson, R. (2002). Hepatic covalent adduct formation with zomepirac in the CD26-deficient mouse. Journal of Gastroenterology and Hepatology, 17(1), 66-71. [More Information]
Shackel, N., McGuinness, P., Abbott, C., Gorrell, M., McCaughan, G. (2002). Insights into the pathobiology of hepatitis C virus-associated cirrhosis. American Journal of Pathology, 160(2), 641-654. [More Information]
Levy, M., McCaughan, G., Marinos, G., Gorrell, M. (2002). Intrahepatic expression of the hepatic stellate cell marker fibroblast activation protein correlates with the degree of fibrosis in hepatitis C virus infection. Liver International, 22(2), 93-101. [More Information]
Abbott, C., Gorrell, M. (2002). The family of CD26/DPIV and related ectopeptidases: the DPIV family. In J Langner, S Ansorge (Eds.), Ectopeptises: CD13/Aminopeptidase N and CD26/Dipeptidylpeptidase IV in Medicine and Biology, (pp. 171-194). New York, USA: Staempfli Publishers Ltd.

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2000

McCaughan, G., Gorrell, M., Bishop, A., Abbott, C., Shackel, N., McGuinness, P., Levy, M., Sharland, A., Bowen, D., Yu, M., Slaitini, L., Napoli, J., et al (2000). Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunological Reviews, 174(1), 172-191. [More Information]

Selected Grants

2021

Understanding advanced fatty liver disease with a noveldegradomics strategy, Gorrell M, Universities Australia/Germany Joint Research Co-operation scheme

2020

Targeting a unique enzyme as a novel therapy for primary liver cancer, Zhang H, Gorrell M, McCaughan G, Majumdar A, Gastroenterological Society of Australia (GESA)/Research Grant
Can exercise training treat established NASH fibrosis in diabetes, Twigg S, Min D, Keating S, Wang X, Johnson N, Gorrell M, Diabetes Australia/Diabetes Research Grant Program

2017

A New Anti-Diabetes Drug as a Novel Therapy for Ovarian Cancer, Gorrell M, Plebanski M, Oehler M, National Health and Medical Research Council (NHMRC)/Project Grants

2016

Novel 3D printed scaffolds for intervertebral fusion, Gorrell M, Rebecca L Cooper Medical Research Foundation/Research Grant FPRx394 SCHx3601

2015

Refrigerated Incubator and Analytical Apparatus, McCaughan G, Gorrell M, Sharland A, Haber P, Church W, Bertolino P, National Health and Medical Research Council (NHMRC)/Equipment Grant
A novel liver cancer therapy targeting tumour stroma, Gorrell M, McCaughan G, Brokopp C, National Health and Medical Research Council (NHMRC)/Development Grants
DPP4 family proteases as drivers of chronic liver injury, Gorrell M, McCaughan G, Twigg S, Bachovchin W, National Health and Medical Research Council (NHMRC)/Project Grants
Novel therapy approaches for diabetes and its liver and heart complications, Gorrell M, Keane F, Tu T, Shackel N, Bowen D, Bertolino P, Seth D, Chen J, Cook A, Liu R, Zheng X, Gamble J, McCaughan G, Rebecca L Cooper Medical Research Foundation/Research Support

2013

Protease therapies for diabetes-associated liver disease, Gorrell M, Keane F, Cook A, Shackel N, Seth D, Chen J, Jolly C, Hare N, McCaughan G, Rebecca L Cooper Medical Research Foundation/Equipment Grant

2012

Wide field super-resolution microscopy with ground state depletion - Exploring nanoscopic life in chronic diseases, Braet F, Weiss A, King N, Dos Remedios C, Traini D, Graeber M, Murphy C, Grau G, Soon L, Newsome T, Goldsbury C, Lovelace M, Gorrell M, Pollock C, DVC Research/Equipment Grant

2011

A novel approach to understanding and preventing tumor development, Gorrell M, Schilling O, Group of Eight/Germany Joint Research Co-operation Scheme
Targeting proteases for a novel therapy for type 2 diabetes and liver complications., Gorrell M, Twigg S, McLennan S, McCaughan G, Chowdhury S, Diabetes Australia Research Trust (DART)/Research Grants
Novel outcome predictors in HCV post-liver transplant, Gorrell M, McCaughan G, Australian Centre for HIV and Hepatitis Virology Research (ACH2)/HIV and Hepatitis C Virology and Immunology Research Grants

2010

The biological roles of dipeptidyl peptidases, Gorrell M, DVC Research/Bridging Support Grant
Automated storage, retrieval, and UV imaging system, Jormakka M, Gamble J, Semsarian C, Rasko J, Vadas M, Xia P, Gorrell M, Clarke R, Holst J, Church W, National Health and Medical Research Council (NHMRC)/Equipment Grant

2009

Next-generation high-speed flow cytometric cell sorter, Fazekas de St Groth B, King N, Simpson S, Britton W, Campbell I, Vadas M, Grau G, Weninger W, Christopherson R, Gamble J, Rasko J, McCaughan G, Xia P, Beale P, Holst J, Haass N, Combes V, Saunders B, Byrne S, West N, Gorrell M, Bertolino P, Bowen D, Warner F, Seth D, Grimshaw M, Jolly C, Martiniello-Wilks R, Mrass P, Lyons J, Sword G, National Health and Medical Research Council (NHMRC)/Equipment Grant
Diabetes exacerbates non-alcoholic steato-hepatitis (NASH), Twigg S, McLennan S, Gorrell M, National Health and Medical Research Council (NHMRC)/Project Grants

2008

Core Resource Facility - application for 7-laser flow cytometer and high content bioimaging system to enhance capabilities and throughput for the NSW Advanced Cytometry Facility, King N, Vadas M, Campbell I, Grau G, Britton W, Fazekas de St Groth B, Richardson D, Halliday G, Christopherson R, Gamble J, Mason R, Rasko J, McCaughan G, Weninger W, Xia P, Gorrell M, Holst J, Pile A, Sword G, McArthur C, Dong Q, Haass N, Sharland A, Saunders B, Triccas J, Norris J, Bertolino P, Bowen D, Sze D, National Health and Medical Research Council (NHMRC)/Equipment Grant
Inverted Multiphoton Intravital Microscope, Gorrell M, Weninger W, Halliday G, Jones C, Fazekas de St Groth B, Richardson D, Clarke S, Gamble J, Bertolino P, Vadas M, Dong Q, Rasko J, Holst J, McCaughan G, Byrne S, Saunders B, Triccas J, Haass N, National Health and Medical Research Council (NHMRC)/Equipment Grant

2007

Therapeutic potential of the dipeptidyl peptidase IV gene family, Gorrell M, National Health and Medical Research Council (NHMRC)/Project Grants
Dako ACIS III Cellular Image Acquisition and Analysis System, Bao B, Bishop A, Black J, Campbell I, Dong Q, Gorrell M, Grau G, Hambly B, Hunt N, King N, Markham R, Marsh D, McDonald K, McLennan S, Rodgers K, Seth D, Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF)
Dako ACIS 111 Cellular Image Acquisition and Analysis System, Hambly B, Bao B, Bishop A, Black J, Campbell I, Dong Q, Gorrell M, Grau G, Hunt N, King N, Markham R, Marsh D, McDonald K, McLennan S, Rodgers K, Seth D, Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF)
a/ BMG Labtech polarstar Omega fluorescence polarization reader with luminescence b/ Dedicated PC, Gorrell M, National Health and Medical Research Council (NHMRC)/Equipment Grant

2004

FACS Aria for the University of Sydney Flow Cytometry Facility, Abendroth A, Armour C, Balcar V, Barnetson R, Bertolino P, Bishop A, Black J, Briscoe H, Byrne S, Christie M, Christopherson R, Cook D, Day M, Dong Q, Gillies M, Gorrell M, Halliday G, Hambly B, Hughes M, Hunt N, King N, Lovicu F, Madigan M, Mason R, McAvoy J, McCaughan G, Menzies S, Murphy C, Pollard J, Pollock C, Rasko J, Reeve V, University of Sydney/Equipment Grant
Role of Dipeptidyl Peptidases in Liver Fibrosis, Ashworth D, Gorrell M, Ferring Research Ltd/Ferring Research Ltd
Cooled gradient palm cycler and rotor-shake genie, Allen R, Bishop A, Chadban S, Gorrell M, Sharland A, National Health and Medical Research Council (NHMRC)/Equipment Grant
Enzyme Inhibition Test for Dipeptidyl Peptidases 8 & 9 (TPL), Gorrell M, McCaughan G, Tadayyon M, Torrent Pharmaceuticals Limited/BLO Project

2002

Nucleic Acid Extraction Facility, Bishop A, Gorrell M, Halliday G, McCaughan G, Rebecca L Cooper Medical Research Foundation/Equipment Grant
Molecular Pathogenesis of alcoholic liver disease, Gorrell M, Haber P, McCaughan G, Hlth & Medical Research Grants/Research Grant

In the media

Interview on coronavirus for Deadly Science radio show, 2020.

Faculty of Medicine and Health

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Professor Mark Gorrell

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In the media