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Neuropathology Research Group

Understanding how brain disorders develop so we can stop dementia

We’re making inroads into understanding what goes wrong in the human brain when neurodegenerative diseases occur and how lifestyle increases risk. We’re also continuously refining the criteria for dementia diagnosis.

We explore the pathogenesis of neurodegenerative diseases to gain insights into the onset and progression of disease and to assist in diagnosis. We provide high quality tissue and associated clinical and lifestyle information to other researchers so they can further the understanding of the brain in health and disease through their research.

We aim to:

  • use histological and molecular techniques to understand how brain disorders develop
  • understand the role lifestyle factors play in disease risk.

We use a range of histological and molecular techniques to understand the pathogenesis of neurodegenerative disorders. We pay particular attention to the role of lifestyle factors in disease risk.

We also run the NSW Brain Tissue Resource Centre, which is funded by the National Institute of Health. The NSW Brain Tissue Resource Centre is an internationally recognised research facility that collects, characterises, stores, and distributes human post-mortem brain tissue to researchers worldwide.

As a leading research group in human neuropathology, we’ve improved understanding of brain diseases and played a role in the formulation of current diagnostic criteria.

We were the first to demonstrate the selective neuronal loss that occurs in alcoholics. We also mapped the pattern and extent of brain atrophy in alcoholics and patients with dementia, especially frontotemporal dementia.

Through the work of the NSW Brain Tissue Resource Centre we’re able to facilitate research into brain function and dysfunction and promote the use of human post-mortem tissue by researchers.

Since opening in 2000, the NSW Brain Tissue Resource Centre has provided over 100,000 tissue samples to researchers who have published close to 500 publications. 

  • Frontotemporal dementia and motor systems degeneration in collaboration with the University of Sydney Brain and Mind Centre, the University of New South Wales Faculty of Science, and the Garvan Institute
  • Diabetes and dementia with collaborators from the University of New South Wales and the University of South Australia
  • Smoking in alcoholics with collaborators from the University of South Australia.

Read more through the Bosch Institute website and the NSW Brain Tissue Resource Centre.

Project lead

Professor Jillian Kril
Professor Jillian Kril
"Being co-located with groups from different faculties and schools has opened up new collaborative opportunities for the group."
View Jillian Kril's profile