Factors that may predict next pandemic

Humans are creating or exacerbating the environmental conditions that could lead to further pandemics, new University of Sydney research finds.

Modelling from the Sydney School of Veterinary Science suggests pressure on ecosystems, climate change and economic development are key factors associated with the diversification of pathogens (disease-causing agents, like viruses and bacteria). This has potential to lead to disease outbreaks.

The research undertaken by Professor Michael Ward, Associate Professor Navneet Dhand and Dr Balbir B Singh is published in the international journal, Transboundary and Emerging Diseases.

They found a greater diversity of zoonotic diseases (diseases transmitted between animals and humans) in higher income countries with larger land areas, more dense human populations, and greater forest coverage.

The study also confirms increasing population growth and density are major drivers in the emergence of zoonotic diseases.

The global human population has increased from about 1.6 billion in 1900 to about 7.8 billion today, putting pressure on ecosystems.

“As the human population increases, so does the demand for housing," said Associate Professor Dhand.

"To meet this demand, humans are encroaching on wild habitats. This increases interactions between wildlife, domestic animals and human beings which increases the potential for bugs to jump from animals to humans.

Zoonotic diseases that have recently devastated human populations include SARS, avian (H5N1) and swine (H1N1) flu, Ebola and Nipah – a bat-borne virus.

“To date, such disease models have been limited, and we continue to be frustrated in understanding why diseases continue to emerge,” said Professor Ward, an infectious diseases expert.

“This information can help inform disease mitigation and may prevent the next COVID-19.”

The researchers discovered country-level factors predicting three categories of disease: zoonotic, emerging (newly discovered diseases, or those diseases that have increased in occurrence or occurred in new locations), and human.

• Zoonotic diseases: land area, human population density, and area of forest. Areas with high zoonotic disease diversity include Europe, North America, Latin America, Australia, and China.
• Emerging diseases: land area, human population density and the human development index. Areas with high emerging disease diversity include Europe, North America, Latin America, and India.
• Human diseases: high per capita health expenditure, mean annual temperature, land area, human population density, human development index and rainfall. Areas with high human disease diversity include North America, Latin America, China and India.

“Countries within a longitude of -50 to -100 like Brazil, developed countries like United States and dense countries such as India were predicted to have a greater diversity of emerging diseases,” Professor Ward said.

The researchers also noted weather variables, such as temperature and rainfall, could influence the diversity of human diseases. At warmer temperatures, there tend to be more emerging pathogens.

Their analyses demonstrate that weather variables (temperature and rainfall) have the potential to influence pathogen diversity.

These factors combined confirm human development – including human-influenced climate change – not only damages our environment but is responsible for the emergence of infectious diseases, such as, potentially, COVID-19.

“Our analysis suggests sustainable development is not only critical to maintaining ecosystems and slowing climate change; it can inform disease control, mitigation, or prevention,” Professor Ward said.

“Due to our use of national-level data, all countries could use these models to inform their public health policies and planning for future potential pandemics.”

Methodology: The authors used 13,892 unique pathogen–country combinations and 49 socioeconomic and environmental variables to develop this model. Information from 190 countries was analysed using statistical models to identify drivers for emerging and zoonotic diseases.

Declaration: The authors would like to thank the Australian Government’s Department of Education and Trainingfor awarding a 2018 Endeavour Research Fellowship to the primary author of this research.

The authors acknowledge the data relied on for this research is incomplete. Reasons include underreporting of some previously known and undiscovered pathogens, particularly in less developed countries. For some of the predictor variables, the latest data available had missing values because recent data had not been updated.