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Oral steroids in sciatica: The OASIS Trial

OASIS is a double-blind, randomised controlled trial of oral steroids for the reduction of leg pain severity in sciatica. We will establish whether adequate, sustained doses of oral steroids can effectively reduce pain, and be safe and cost-effective in people with acute sciatica.

Participants will receive one of the interventions (a daily dose of an oral steroid or placebo). Both groups will be asked to complete 6 surveys over 12 months and provide a daily pain score for up to 3 months.

Eligibility

You will not be able to participate in this study if you:

have serious spinal pathology
have contraindications or precautions to glucocorticoids where risks outweigh potential benefit
are planning to undergo spinal surgery
had spinal surgery or other interventional procedures (e.g. an epidural injection) in the preceding 6 months
have used a systemic glucocorticoid (for any condition) via any method of administration since the start of this episode of sciatica.
females who are pregnant, breast feeding or planning conception

How to participate

If you are interested, please contact us or complete your online pre-screen at: https://www.oasis-trial.com/

Ethics committee approval number: 2019/740

Looking for volunteers?

Find out how to get your study listed here