People_
Dr Aviva Levina
Senior Research Associate
Address
F11 - Chemistry Building
The University of Sydney
Details
Member of The Centre for Drug Discovery Innovation
Publications
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Book Chapters
- Levina, A., Lay, P. (2019). Redox chemistry and biological activities of chromium(III) complexes. In John B. Vincent (Eds.), The Nutritional Biochemistry of Chromium (III), (pp. 281-321). Amsterdam: Elsevier. [More Information]
- Levina, A., Codd, R., Lay, P. (2009). Chromium in cancer and dietary supplements. In G. R. Hanson and L. J. Berliner (Eds.), Biological Magnetic Resonance: High Resolution EPR Applications to Metalloenzymes and Metals in Medicine, (pp. 551-579). NY, USA: Springer. [More Information]
- Levina, A., Mulyani, I., Lay, P. (2007). Redox chemistry and biological activities of chromium(III) complexes. In J. B. Vincent (Eds.), The Nutritional Biochemistry of Chromium(III), (pp. 225-256). Amsterdam, Netherlands: Elsevier. [More Information]
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Journals
- Haase, A., Zadrozny, J., Levina, A., Lay, P., Crans, D., Markham, S., Murakami, H., Hagan, J., Kostenkova, K., Koehn, J., Uslan, C., et al (2024). Halogenated non-innocent vanadium(v) Schiff base complexes: chemical and anti-proliferative properties. New Journal of Chemistry. [More Information]
- Ryder, W., Levina, A., Graziotto, M., Hawkins, B., Hibbs, D., New, E., Gale, P. (2024). Subcellular targeted anion transporters. Chem. [More Information]
- Mohammed Asiri, S., Levina, A., New, E., Lay, P. (2023). Investigations of cellular copper metabolism in ovarian cancer cells using a ratiometric fluorescent copper dye. Journal of Biological Inorganic Chemistry, 28(1), 43-55. [More Information]
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Conferences
- Safitri, A., Levina, A., Lee, J., Carter, E., Lay, P. (2017). Biospectroscopy for studying the influences of anti-diabetic metals (V, Cr, Mo, and W) to the insulin signaling pathway. International Conference on Chemistry, Chemical Process and Engineering (IC3PE 2017), Melville, NY: AIP Publishing. [More Information]
- Levina, A., Aitken, J., Harris, H., McLeod, A., Lim, Z., Singharay, A., Pham, T., Safitri, A., Wu, L., Lay, P. (2009). Applications of X-ray absorption spectroscopy to the studies of metabolism of biologically active metal complexes. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
- Tarr, S., Carter, E., Whan, R., Levina, A., Tobin, M., Lay, P. (2009). Mapping and fluorescent imaging: Investigating the effects of fluorophores on intracellular biochemistry. International Conference on Advanced Vibrational Spectroscopy, N/A: N/A.
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2024
- Haase, A., Zadrozny, J., Levina, A., Lay, P., Crans, D., Markham, S., Murakami, H., Hagan, J., Kostenkova, K., Koehn, J., Uslan, C., et al (2024). Halogenated non-innocent vanadium(v) Schiff base complexes: chemical and anti-proliferative properties. New Journal of Chemistry. [More Information]
- Ryder, W., Levina, A., Graziotto, M., Hawkins, B., Hibbs, D., New, E., Gale, P. (2024). Subcellular targeted anion transporters. Chem. [More Information]
2023
- Mohammed Asiri, S., Levina, A., New, E., Lay, P. (2023). Investigations of cellular copper metabolism in ovarian cancer cells using a ratiometric fluorescent copper dye. Journal of Biological Inorganic Chemistry, 28(1), 43-55. [More Information]
- Levina, A., Uslan, C., Murakami, H., Crans, D., Lay, P. (2023). Substitution Kinetics, Albumin and Transferrin Affinities, and Hypoxia All Affect the Biological Activities of Anticancer Vanadium(V) Complexes. Inorganic Chemistry, 62(43), 17804-17817. [More Information]
- Stephens, L., Dallerba, E., Kelderman, J., Levina, A., Werrett, M., Lay, P., Massi, M., Andrews, P. (2023). Synthesis and the photophysical and biological properties of tricarbonyl Re(i) diimine complexes bound to thiotetrazolato ligands. Dalton Transactions, 52(15), 4835-4848. [More Information]
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2022
- Levina, A., Crans, D., Lay, P. (2022). Advantageous Reactivity of Unstable Metal Complexes: Potential Applications of Metal-Based Anticancer Drugs for Intratumoral Injections. Pharmaceutics, 14(4). [More Information]
- Levina, A., Chetcuti, A., Lay, P. (2022). Controversial Role of Transferrin in the Transport of Ruthenium Anticancer Drugs. Biomolecules, 12(9). [More Information]
- Levina, A., Wang, B., Lay, P. (2022). Urea gel electrophoresis in studies of conformational changes of transferrin on binding and transport of non-ferric metal ions. Gels, 8(1), 19. [More Information]
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2020
- Levina, A., Pires Vieira, A., Wijetunga, A., Kaur, R., Koehn, J., Crans, D., Lay, P. (2020). A Short-Lived but Highly Cytotoxic Vanadium(V) Complex as a Potential Drug Lead for Brain Cancer Treatment by Intratumoral Injections. Angewandte Chemie - International Edition, 59(37), 15834-15838. [More Information]
- Stephens, L., Levina, A., Trinh, I., Blair, V., Werrett, M., Lay, P., Andrews, P. (2020). Ruthenium(II)–Arene Thiocarboxylates: Identification of a Stable Dimer Selectively Cytotoxic to Invasive Breast Cancer Cells. ChemBioChem, 21(8), 1188-1200. [More Information]
- Levina, A., Lay, P. (2020). Vanadium(V/IV)-Transferrin Binding Disrupts the Transferrin Cycle and Reduces Vanadium Uptake and Antiproliferative Activity in Human Lung Cancer Cells. Inorganic Chemistry, 59(22), 16143-16153. [More Information]
2019
- Crans, D., Koehn, J., Petry, S., Glover, C., Wijetunga, A., Kaur, R., Levina, A., Lay, P. (2019). Hydrophobicity may enhance membrane affinity and anti-cancer effects of Schiff base vanadium(V) catecholate complexes. Dalton Transactions, 48(19), 6383-6395. [More Information]
- Liang, J., Levina, A., Jia, J., Kappen, P., Glover, C., Johannessen, B., Lay, P. (2019). Reactivity and transformation of antimetastatic and cytotoxic rhodium(III)-dimethyl sulfoxide complexes in biological fluids: An XAS speciation study. Inorganic Chemistry, 58(8), 4880-4893. [More Information]
- Levina, A., Lay, P. (2019). Redox chemistry and biological activities of chromium(III) complexes. In John B. Vincent (Eds.), The Nutritional Biochemistry of Chromium (III), (pp. 281-321). Amsterdam: Elsevier. [More Information]
show 2 more
2017
- Markham, J., Liang, J., Levina, A., Mak, R., Johannessen, B., Kappen, P., Glover, C., Lai, B., Vogt, S., Lay, P. (2017). (Pentamethylcyclopentadienato)rhodium complexes for delivery of the curcumin anticancer drug. European Journal of Inorganic Chemistry, 2017 (12), 1812-1823. [More Information]
- Safitri, A., Levina, A., Lay, P. (2017). Biospeciation of Cr(III) nutritional supplements in biological fluids. Makara Journal of Science, 21(2), 83-90. [More Information]
- Safitri, A., Levina, A., Lee, J., Carter, E., Lay, P. (2017). Biospectroscopy for studying the influences of anti-diabetic metals (V, Cr, Mo, and W) to the insulin signaling pathway. International Conference on Chemistry, Chemical Process and Engineering (IC3PE 2017), Melville, NY: AIP Publishing. [More Information]
show 4 more
2016
- Levina, A., Pham, T., Lay, P. (2016). Binding of chromium(III) to transferrin could be involved in detoxification of dietary chromium(III) rather than transport of an essential trace element. Angewandte Chemie - International Edition, 55(28), 8104-8107. [More Information]
- Wu, L., Levina, A., Harris, H., Cai, Z., Lai, B., Vogt, S., James, D., Lay, P. (2016). Carcinogenic chromium(VI) compounds formed by intracellular oxidation of chromium(III) dietary supplements by adipocytes. Angewandte Chemie - International Edition, 55(5), 1742-1745. [More Information]
- Gransbury, G., Kappen, P., Glover, C., Hughes, J., Levina, A., Lay, P., Musgrave, I., Harris, H. (2016). Comparison of KP1019 and NAMI-A in tumour-mimetic environments. Metallomics, 8(8), 762-773. [More Information]
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2015
- Levina, A., McLeod, A., Pulte, A., Aitken, J., Lay, P. (2015). Biotransformations of antidiabetic vanadium prodrugs in mammalian cells and cell culture media: A XANES spectroscopic study. Inorganic Chemistry, 54(14), 6707-6718. [More Information]
- Weeks, C., Levina, A., Fenton, R., Lay, P. (2015). EXAFS and EPR studies of the alkene oxidation catalyst species trans-[CrIII(bpb)(L)2]n+ and Crv oxidation products (bpb = N,N'-bis(2-pyridinecarboxamido)-1,2-benzene). Australian Journal of Chemistry, 68(4), 581-592. [More Information]
- Levina, A., McLeod, A., Gasparini, S., Nguyen, A., De Silva, W., Aitken, J., Harris, H., Glover, C., Johannessen, B., Lay, P. (2015). Reactivity and speciation of anti-diabetic vanadium complexes in whole blood and its components: The important role of red blood cells. Inorganic Chemistry, 54(16), 7753-7766. [More Information]
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2014
- Levina, A., Lay, P. (2014). Influence of an anti-metastatic ruthenium(III) prodrug on extracellular protein-protein interactions: studies by bio-layer interferometry. Inorganic Chemistry Frontiers, 1(1), 44-48. [More Information]
- Levina, A., McLeod, A., Kremer, L., Aitken, J., Glover, C., Johannessen, B., Lay, P. (2014). Reactivity-activity relationships of oral anti-diabetic vanadium complexes in gastrointestinal media: an X-ray absorption spectroscopic study. Metallomics, 6(10), 1880-1888. [More Information]
- Pham, T., Aitken, J., Levina, A., Lay, P. (2014). Solid-state structural studies of chromium(III) nicotinato nutritional supplements. Inorganic Chemistry, 53(19), 10685-10694. [More Information]
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2013
- Levina, A., Aitken, J., Gwee, Y., Lim, Z., Liu, M., Singharay, A., Wong, P., Lay, P. (2013). Biotransformations of anticancer ruthenium(III) complexes: An X-ray absorption spectroscopic study. Chemistry - A European Journal, 19(11), 3609-3619. [More Information]
- Bartholomaus, R., Irwin, J., Shi, L., Meejoo Smith, S., Levina, A., Lay, P. (2013). Isolation, Characterization, and Nuclease Activity of Biologically Relevant Chromium(V) Complexes with Monosaccharides and Model Diols. Likely Intermediates in Chromium-Induced Cancers. Inorganic Chemistry, 52(8), 4282-4292. [More Information]
2012
- Bartholomaus, R., Harms, K., Levina, A., Lay, P. (2012). Synthesis and characterization of a chromium(V) cis-1,2-cyclohexanediolato complex: A model of reactive intermediates in chromium-induced cancers. Inorganic Chemistry, 51(21), 11238-11240. [More Information]
- George, G., Pickering, I., Pushie, M., Nienaber, K., Hackett, M., Ascone, I., Hedman, B., Hodgson, K., Aitken, J., Levina, A., Lay, P., et al (2012). X-ray-induced photo-chemistry and X-ray absorption spectroscopy of biological samples. Journal of Synchrotron Radiation, 19(6), 875-886. [More Information]
2011
- Hackett, M., McQuillan, J., El Assaad, F., Aitken, J., Levina, A., Cohen, D., Siegele, R., Carter, E., Grau, G., Hunt, N., Lay, P. (2011). Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis. Analyst, 136(14), 2941-2952. [More Information]
- Levina, A., Lay, P. (2011). Metal-based anti-diabetic drugs: Advances and challenges. Dalton Transactions, 40(44), 11675-11686. [More Information]
- Aitken, J., Levina, A., Lay, P. (2011). Studies on the Biotransformations and Biodistributions of Metal-Containing Drugs Using X-ray Absorption Spectroscopy. Current Topics in Medicinal Chemistry, 11(5), 553-571. [More Information]
2010
- Liu, M., Lim, Z., Gwee, Y., Levina, A., Lay, P. (2010). Characterization of a ruthenium(III)/NAMI-A adduct with bovine serum albumin that exhibits a high anti-metastatic activity. Angewandte Chemie - International Edition, 49(9), 1661-1664. [More Information]
- Levina, A., Zhang, L., Lay, P. (2010). Formation and reactivity of chromium(V)-thiolato complexes: A model for the intracellular reactions of carcinogenic chromium(VI) with biological thiols. Journal of the American Chemical Society, 132(25), 8720-8731. [More Information]
- Finney, L., Chishti, Y., Khare, T., Giometti, C., Levina, A., Lay, P., Vogt, S. (2010). Imaging metals in proteins by combining electrophoresis with rapid X-ray fluorescence mapping. ACS Chemical Biology, 5(6), 577-587. [More Information]
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2009
- Levina, A., Aitken, J., Harris, H., McLeod, A., Lim, Z., Singharay, A., Pham, T., Safitri, A., Wu, L., Lay, P. (2009). Applications of X-ray absorption spectroscopy to the studies of metabolism of biologically active metal complexes. 14th International Conference on Biological Inorganic Chemistry, N/A: N/A.
- Aitken, J., Carter, E., Eastgate, H., Hackett, M., Harris, H., Levina, A., Lee, Y., Chen, C., Lai, B., Vogt, S., Lay, P. (2009). Biomedical applications of X-ray absorption and vibrational spectroscopic microscopies in obtaining structural information from complex systems. Radiation Physics and Chemistry, 79(2), 176-184. [More Information]
- Levina, A., Codd, R., Lay, P. (2009). Chromium in cancer and dietary supplements. In G. R. Hanson and L. J. Berliner (Eds.), Biological Magnetic Resonance: High Resolution EPR Applications to Metalloenzymes and Metals in Medicine, (pp. 551-579). NY, USA: Springer. [More Information]
show 4 more
2008
- Chatterjee, D., Singharay, A., Levina, A., Lay, P. (2008). A potential role for protein tyrosine phosphatase inhibition by a Ru(III)-edta complex (edta = ethylenediaminetetraacetate) in its biological activity. Chemical Communications, 2008 (25), 2864-2866. [More Information]
- Levina, A., Lay, P. (2008). Chemical properties and toxicity of chromium(III) nutritional supplements. Chemical Research in Toxicology, 21(3), 563-571. [More Information]
- Nguyen, A., Mulyani, I., Levina, A., Lay, P. (2008). Reactivity of chromium(III) nutritional supplements in biological media: An X-ray absorption spectroscopic study. Inorganic Chemistry, 47(10), 4299-4309. [More Information]
2007
- Thomas, S., Terentis, A., Cai, H., Takikawa, O., Levina, A., Lay, P., Freewan, M., Stocker, R. (2007). Post-translational regulation of human indoleamine 2,3-dioxygenase activity by nitric oxide. Journal of Biological Chemistry, 282(33), 23778-23787. [More Information]
- Levina, A., McLeod, A., Seuring, J., Lay, P. (2007). Reactivity of potential anti-diabetic molybdenum(VI) complexes in biological media: A XANES spectroscopic study. Journal of Inorganic Biochemistry, 101(11-12), 1586-1593. [More Information]
- Levina, A., Mulyani, I., Lay, P. (2007). Redox chemistry and biological activities of chromium(III) complexes. In J. B. Vincent (Eds.), The Nutritional Biochemistry of Chromium(III), (pp. 225-256). Amsterdam, Netherlands: Elsevier. [More Information]
show 1 more
2006
- Levina, A., Harris, H., Lay, P. (2006). Binding of chromium(VI) to histones: implications for chromium(VI)-induced genotoxicity. Journal of Biological Inorganic Chemistry, 11(2), 225-234. [More Information]
- Milsmann, C., Levina, A., Harris, H., Foran, G., Turner, P., Lay, P. (2006). Charge distribution in chromium and vanadium catecholato complexes: X-ray absorption spectroscopic and computational studies. Inorganic Chemistry, 45(12), 4743-4754. [More Information]
- Shi, L., Jing, H., Ren, G., Levina, A., Lay, P. (2006). Studies on the mechanism of Cr-induced DNA damage in glucose and its derivative. Weisheng Yanjiu, 35, 348-351.
2005
- Immoos, C., Sulc, F., Farmer, P., Czarnecki, K., Bocian, D., Levina, A., Aitken, J., Armstrong, R., Lay, P. (2005). Bonding in HNO-myoglobin as characterized by X-ray absorption and resonance Raman spectroscopies. Journal of the American Chemical Society, 127(3), 814-815. [More Information]
- Mactier, S., Luxenhofer, R., Levina, A., Codd, R., Lay, P. (2005). Chromium(V) complexes of hydroxamic acids: Formation, structures, and reactivities. Inorganic Chemistry, 44(8), 2934-2943. [More Information]
- Barnard, P., Levina, A., Lay, P. (2005). Chromium(V) peptide complexes: Synthesis and spectroscopic characterization. Inorganic Chemistry, 44(4), 1044-1053. [More Information]
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2004
- Mulyani, I., Levina, A., Lay, P. (2004). Biomimetic Oxidation Of Chromium(III): Does The Antidiabetic Activity Of Chromium(III) Involve Carcinogenic Chromium(VI)? Angewandte Chemie - International Edition, 43(34), 4504-4507. [More Information]
- Lay, P., Levina, A. (2004). Chromium. In A. G. Webb (Eds.), Comprehensive Coordination Chemistry II : From Biology to Nanotechnology [Volume 4: Transition Metal Groups 3-6], (pp. 313-413). Amsterdam: Pergamon Elsevier. [More Information]
- Levina, A., Lay, P. (2004). Solution Structures Of Chromium(Vi) Complexes With Glutathione And Model Thiols. Inorganic Chemistry, 43(1), 324-335. [More Information]
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2003
- Levina, A., Codd, R., Dillon, C., Lay, P. (2003). Chromium in Biology: Toxicology and Nutritional aspects. In Karlin, Kenneth D (Eds.), Progress in Inorganic Chemistry, Volume 51, (pp. 145-250). Hoboken: John Wiley & Sons.
- Mulyani, I., Levina, A., Lay, P. (2003). Chromium(III) complexes used as nutritional supplements: structures and reactivities. Journal of Inorganic Biochemistry, 961, 196.
- Levina, A., Zhang, L., Lay, P. (2003). Structure and reactivity of a chromium(V) glutathione complex. Inorganic Chemistry, 42(3), 767-784. [More Information]
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2002
- Rizzotto, M., Levina, A., Santoro, M., GarcÃa, S., Frascaroli, M., Signorella, S., Sala, L., Lay, P. (2002). Redox and ligand-exchange chemistry of chromium(VI/V)-methyl glycoside systems. Dalton Transactions, , 3206-3213. [More Information]
2001
- Pattison, D., Levina, A., Lay, P., Davies, M. (2001). An investigation of the chromium oxidation state of a monoanionic chromium tris(catecholate) complex by X-ray absorption and EPR spectroscopies. Inorganic Chemistry, 40, 214-217. [More Information]
- Pattison, D., Levina, A., Lay, P., Davies, M., Dixon, N. (2001). Chromium(VI) reduction by catechol(amine)s results in DNA cleavage in vitro: Relevance to chromium genotoxicity. Chemical Research in Toxicology, 14, 500-510. [More Information]
- Levina, A., Lay, P., Dixon, N. (2001). Disproportionation of a model chromium(V) complex causes extensive chromium(III)-DNA binding in vitro. Chemical Research in Toxicology, 14, 946-950. [More Information]
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2000
- Codd, R., Levina, A., Zhang, L., Hambley, T., Lay, P. (2000). Characterization and X-ray absorption spectroscopic studies of bis[quinato(2)]oxochromate(V). Inorganic Chemistry, 39(5), 990-997.
Selected Grants
2011
- Chromium and vanadium complexes: biotransformations in biological fluids and cells (ANBF), Levina A, Lay P, Australian Synchrotron/International Access Program