Peter is a Professor of Chemistry at The University of Sydney. He received his BSc (Chemistry & Biochemistry) and MSc (Chemistry) from the University of Auckland, and completed his DPhil at the Dyson Perrins Laboratory in Oxford, working on penicillin biosynthesis with Professor Sir Jack Baldwin.

Research interests

Antibiotics Chemistry: The rise and rise of the so-called 'Superbugs' is well documented in the media. Bacteria that are resistant to (i.e. not killed by) most current antibiotics are increasingly widespread, and the need for new drugs and new strategies to combat them grows ever more important. We are widely interested in antibiotics chemistry and antibiotic biosynthesis, and are pursuing a number of approaches to meet the challenges posed by antibiotic resistant bacteria. Current strategies include the synthesis of new cyclobutanone antibiotics and the design of antibiotics with novel 'double-punch' and 'resistance-activated' modes of action.

Hydrocarbon Oxidation and C-H Activation:The conversion of simple hydrocarbons (alkanes, alkenes and aromatic compounds) to functionalised targets is of great interest in synthetic and medicinal chemistry, but many of these key transformations are inaccessible with current synthetic methods. Nature uses highly efficient enzyme systems to oxidise hydrocarbons in high yield with complete selectivity. We are working to develop new catalysts inspired by these biological systems, and to use them for the selective oxidation of hydrocarbon substrates: new reagents for synthesis and for the environment. We have synthesised a series of small-molecule systems that mimic the non-heme iron oxidase (NHIO) active site and are developing these as catalysts for biomimetic hydrocarbon oxidation and iron-mediated C-H activation.

Metal Sensing: Heavy metals like cadmium and mercury form some of the most toxic materials known. Yet some plants and microbes have developed strategies to live in locales prone to high levels of cadmium and mercury pollution, using sulfur-rich proteins to bind and the toxic metal ions and sequester them away from the rest of the cell's machinery. These proteins incorporate high numbers of cysteine residues, which makes them effective agents for heavy metal sequestration: the numerous sulfur atoms bind tightly to mercury, cadmium and other metal ions. Our approach uses thiol- and sulfide-rich peptides as agents for binding and sensing mercury.

Nitrile Hydratase Mimics and Mechanism: Nitrile hydratase is an unusual metalloenzyme that brings about the selective conversion of nitriles to primary amides. Crystal structures of nitrile hydratases show a remarkable ligand environment in the active site. Two nitrogen atoms from main-chain amides bind to the metal (iron(III) or cobalt(III)), along with three sulfur atoms, each in a different oxidation state. And these five metal binding ligands are located in a short section of the primary sequence, spread across only six amino acids in one peptide chain. We are working to develop new peptide-based systems as bio-inspired catalysts for nitrile hydration, to study the unusual sulfur oxidation that occurs at the nitrile hydratase active site, and to elucidate a detailed mechanism for nitrile hydratase catalysis.

For further details on all of these areas, please visit http://sydney.edu.au/science/chemistry/~rutledge/

Awards and honours

Faculty of Science Award for Outstanding Teaching (2019)
Pearson Education RACI Centenary of Federation Chemistry Educator of the Year Award (2012)
Vice-Chancellor's Award for Outstanding Teaching (2011)
Vice-Chancellor's Award for Support of the Student Experience (2010)
RACI NSW President's Citation (2009)
NSW and ACT Young Tall Poppy Science Award (2008)
RACI Athel Beckwith Lectureship (2007)
RACI Nyholm Lectureship (2006)

PhD and master's project opportunities

‘Magic Bullet’ Cancer Drugs and Antibiotics

Current research students

Project title	Research student
Peptide inhibitors targeting FANCM RMI interaction as a novel therapeutic strategy against ALT positive cancers	Eva GAO
Total synthesis of polycyclic ethers	Shaolei YAO

Publications

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Book Chapters

Motion, A., Golumbic, Y., Pullen, R., Rutledge, P. (2023). One-Line Stories as Connections Between Slides. In Susan Rowland, Louise Kuchel (Eds.), Teaching Science Students to Communicate: A Practical Guide, (pp. 331-335). Switzerland: Springer Nature Switzerland. [More Information]
Rutledge, P. (2015). Isopenicillin N Synthase. In Robert P. Hausinger, Christopher J. Schofield (Eds.), 2-Oxoglutarate-Dependent Oxygenases, (pp. 414-424). Cambridge: RSC Publishing. [More Information]
Rutledge, P. (2005). Nitriles with a heteroatom attached to the cyanocarbon. In Alan R Katritzky and Richard JK Taylor (Eds.), Comprehensive organic functional group transformationsII, (pp. 1023-1080). UK: Pergamon Elsevier.

Journals

Xie, S., Wang, Y., Morton, C., Metcalfe, R., Dogovski, C., Pasaje, C., Dunn, E., Luth, M., Kumpornsin, K., Istvan, E., Rutledge, P., et al (2024). Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature Communications, 15(1). [More Information]
Preston, C., Golumbic, Y., Kenneally, C., Phway, T., Rutledge, P., Martin, J., Braz Sousa, L., Motion, A. (2023). Citizen science in schools - Perceptions of project leaders and teachers. Teaching Science, 69(3), 22-35.
Scroggie, K., Burrell-Sander, K., Rutledge, P., Motion, A. (2023). GitHub as an open electronic laboratory notebook for real-time sharing of knowledge and collaboration. Digital Discovery, 2(4), 1188-1196. [More Information]
Golumbic, Y., Scroggie, K., Kenneally, C., Lin, J., Blyth, M., Firmer, G., Rutledge, P., Motion, A. (2023). Meet the Medicines—A Crowdsourced Approach to Collecting and Communicating Information about Essential Medicines Online. International Journal of Environmental Research and Public Health, 20(5). [More Information]
Ball, S., Adamson, J., Sullivan, M., Zimmermann, M., Lo, V., Sanz-Hernandez, M., Jiang, X., Kwan, A., McKenzie, A., Werry, E., Kassiou, M., Rutledge, P., Sunde, M., et al (2023). Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid. ACS Chemical Neuroscience, 14(1), 87-98. [More Information]
Lacey, H., Chen, R., Vuong, D., Lacey, E., Rutledge, P., Chooi, Y., Piggott, A., Booth, T. (2023). Resorculins: hybrid polyketide macrolides from Streptomyces sp. MST-91080. Organic and Biomolecular Chemistry, 21(12), 2531-2538. [More Information]
Smith, N., Quan, D., Nagalingam, G., Triccas, J., Rendina, L., Rutledge, P. (2022). Carborane clusters increase the potency of bis-substituted cyclam derivatives against Mycobacterium tuberculosis. RSC Medicinal Chemistry, 13(10), 1234-1238. [More Information]
Lacey, H., Rutledge, P. (2022). Recently Discovered Secondary Metabolites from Streptomyces Species. Molecules, 27(3), 887. [More Information]
Lacey, H., Chen, R., Vuong, D., Fisher, M., Lacey, E., Rutledge, P., Piggott, A. (2022). Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3. The Journal of Antibiotics, 75(9), 483-490. [More Information]
Lacey, H., Chen, R., Vuong, D., Cowled, M., Lacey, E., Rutledge, P., Piggott, A. (2022). Yeppoonic acids A-D: 1,2,4-trisubstituted arene carboxylic acid co-metabolites of conglobatin from an Australian Streptomyces sp. The Journal of Antibiotics, 75(2), 108-112. [More Information]
Counsell, A., Yu, M., Shi, M., Jones, A., Batten, J., Turner, P., Todd, M., Rutledge, P. (2021). Copper(ii) complexes ofN-propargyl cyclam ligands reveal a range of coordination modes and colours, and unexpected reactivity. Dalton Transactions, 50(11), 3931-3942. [More Information]
Chapman, N., Rutledge, P. (2021). Isopenicillin N Synthase: Crystallographic Studies. ChemBioChem, 22(10), 1687-1705. [More Information]
George-Williams, S., Motion, A., Pullen, R., Rutledge, P., Schmid, S., Wilkinson, S. (2020). Chemistry in the Time of COVID-19: Reflections on a Very Unusual Semester. Journal of Chemical Education. [More Information]
Lacey, H., Booth, T., Vuong, D., Rutledge, P., Lacey, E., Chooi, Y., Piggott, A. (2020). Conglobatins B-E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin. The Journal of Antibiotics, 73(11), 756-765. [More Information]
Frei, A., Zuegg, J., Elliott, A., Baker, M., Braese, S., Brown, C., Chen, F., G. Dowson, C., Dujardin, G., Jung, N., Renfrew, A., Rutledge, P., Todd, M., et al (2020). Metal complexes as a promising source for new antibiotics. Chemical Science, 11(10), 2627-2639. [More Information]
Korsik, M., Tse, E., Smith, D., Lewis, W., Rutledge, P., Todd, M. (2020). tele-Substitution Reactions in the Synthesis of a Promising Class of 1,2,4-Triazolo[4,3- a]pyrazine-Based Antimalarials. The Journal of Organic Chemistry, 85(21), 13438-13452. [More Information]
Quan, D., Nagalingam, G., Luck, I., Proschogo, N., Pillalamarri, V., Addlagatta, A., Martinez, E., Sintchenko, V., Rutledge, P., Triccas, J. (2019). Bengamides display potent activity against drug-resistant Mycobacterium tuberculosis. Scientific Reports, 9(1), 14396. [More Information]
Lacey, H., Gilchrist, C., Crombie, A., Kalaitzis, J., Vuong, D., Rutledge, P., Turner, P., Pitt, J., Lacey, E., Chooi, Y., et al (2019). Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis. Beilstein Journal of Organic Chemistry, 15, 2631-2643. [More Information]
Spain, M., Wong, J., Nagalingam, G., Batten, J., Hortle, E., Oehlers, S., Jiang, X., Murage, H., Orford, J., Crisologo, P., Triccas, J., Rutledge, P., Todd, M. (2018). Antitubercular bis-substituted cyclam derivatives: Structure-activity relationships and in vivo studies. Journal of Medicinal Chemistry, 61(8), 3595-3608. [More Information]
Guardia, A., Baiget, J., Cacho, M., Perez, A., Ortega-Guerra, M., Nxumalo, W., Khanye, S., Rullas, J., Ortega, F., Jimenez, E., Osende, J., Badiola, K., Rutledge, P., Todd, M., et al (2018). Easy-to-synthesize spirocyclic compounds possess remarkable in vivo activity against Mycobacterium tuberculosis. Journal of Medicinal Chemistry, 61(24), 11327-11340. [More Information]
Lau, Y., Clegg, J., Price, J., Macquart, R., Todd, M., Rutledge, P. (2018). Molecular Switches for any pH: A Systematic Study of the Versatile Coordination Behaviour of Cyclam Scorpionands. Chemistry - A European Journal, 24(7), 1573-1585. [More Information]
Devi, P., Rutledge, P. (2017). Cyclobutanone analogues of (Beta)-lactam antibiotics: (Beta)-lactamase inhibitors with untapped potential? ChemBioChem, 18(4), 338-351. [More Information]
Wong, J., Todd, M., Rutledge, P. (2017). Recent advances in macrocyclic fluorescent probes for ion sensing. Molecules, 22(2), 1-28. [More Information]
Wong, J., Proschogo, N., Todd, M., Rutledge, P. (2017). Selective displacement of a scorpionand triazole ligand from metallocyclam complexes visualised with NMR spectroscopy. European Journal of Inorganic Chemistry, 2017 (7), 1075-1086. [More Information]
McNeill, L., Brown, T., Sami, M., Clifton, I., Burzlaff, N., Claridge, T., Adlington, R., Baldwin, J., Rutledge, P., Schofield, C. (2017). Terminally truncated isopenicillin N synthase generates a dithioester product: Evidence for a thioaldehyde intermediate during catalysis and a new mode of reaction for non-heme iron oxidases. Chemistry - A European Journal, 23(52), 12815-12824. [More Information]
Hossain, M., Canning, J., Yu, Z., Ast, S., Rutledge, P., Wong, J., Jamalipour, A., Crossley, M. (2017). Time-resolved and temperature tuneable measurements of fluorescent intensity using a smartphone fluorimeter. Analyst, 142(11), 1953-1961. [More Information]
Counsell, A., Jones, A., Todd, M., Rutledge, P. (2016). A direct method for the N-tetraalkylation of azamacrocycles. Beilstein Journal of Organic Chemistry, 12, 2457-2461. [More Information]
Yu, M., Nagalingam, G., Ellis, S., Martinez, E., Sintchenko, V., Spain, M., Rutledge, P., Todd, M., Triccas, J. (2016). Nontoxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis. Journal of Medicinal Chemistry, 59(12), 5917-5921. [More Information]
Wong, J., Ast, S., Yu, M., Flehr, R., Counsell, A., Turner, P., Crisologo, P., Todd, M., Rutledge, P. (2016). Synthesis and evaluation of 1,8-disubstituted-cyclam/naphthalimide conjugates as probes for metal ions. ChemistryOpen, 5(4), 375-385. [More Information]
Canning, J., Ast, S., Hossain, M., Chan, H., Rutledge, P., Jamalipour, A. (2015). Bend and twist intramolecular charge transfer and emission for selective metal ion sensing. Optical Materials Express, 5(11), 2675-2681. [More Information]
Hossain, M., Canning, J., Ast, S., Cook, K., Rutledge, P., Jamalipour, A. (2015). Combined "dual" absorption and fluorescence smartphone spectrometers. Optics Letters, 40(8), 1737-1740. [More Information]
Rutledge, P., Challis, G. (2015). Discovery of microbial natural products by activation of silent biosynthetic gene clusters. Nature Reviews Microbiology, 13(8), 509-523. [More Information]
Hossain, M., Canning, J., Ast, S., Rutledge, P., Jamalipour, A. (2015). Early Warning Smartphone Diagnostics for Water Security and Analysis Using Real-Time pH Mapping. Photonic Sensors, 5(4), 289-297. [More Information]
Yu, M., Wong, J., Tang, C., Turner, P., Todd, M., Rutledge, P. (2015). Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Bronsted acids. Beilstein Journal of Organic Chemistry, 11, 37-41. [More Information]
Porter, D., Poon, B., Rutledge, P. (2015). Iron complexes of tetramine ligands catalyse allylic hydroxy-amination via a nitroso-ene mechanism. Beilstein Journal of Organic Chemistry, 11, 2549-2556. [More Information]
Hossain, M., Canning, J., Ast, S., Rutledge, P., Yen, T., Jamalipour, A. (2015). Lab-in-a-phone: Smartphone-based portable fluorometer for pH measurements of environmental water. IEEE Sensors Journal, 15(9), 5095-5102. [More Information]
Devi, P., Barry, S., Houlihan, K., Murphy, M., Turner, P., Jensen, P., Rutledge, P. (2015). Synthesis and structural characterisation of amides from picolinic acid and pyridine-2,6-dicarboxylic acid. Scientific Reports, 9, 1-6. [More Information]
Ast, S., Kuke, S., Rutledge, P., Todd, M. (2015). Using click chemistry to tune the properties and the fluorescence response mechanism of structurally similar probes for metal ions. European Journal of Inorganic Chemistry, 2015 (1), 58-66. [More Information]
Byrne, C., Houlihan, K., Devi, P., Jensen, P., Rutledge, P. (2014). Bio-inspired nitrile hydration by peptidic ligands based on L-cysteine, L-methionine or L-penicillamine and pyridine-2,6-dicarboxylic acid. Molecules, 19(12), 20751-20767. [More Information]
Yu, M., Ast, S., Yu, Q., Lo, A., Flehr, R., Todd, M., Rutledge, P. (2014). Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates. PloS One, 9(7), 1-12. [More Information]
Yu, M., Ryan, T., Ellis, S., Bush, A., Triccas, J., Rutledge, P., Todd, M. (2014). Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid beta. Metallomics, 6(10), 1931-1940. [More Information]
Ast, S., Rutledge, P., Todd, M. (2014). pH-Responsive quantum dots (RQDs) that combine a fluorescent nanoparticle with a pH-sensitive dye. Physical Chemistry Chemical Physics, 16(46), 25255-25257. [More Information]
Ast, S., Rutledge, P., Todd, M. (2014). The properties and performance of a pH-responsive functionalised nanoparticle. Faraday Discussions, 175, 171-187. [More Information]
Yu, M., Yu, Q., Rutledge, P., Todd, M. (2013). A fluorescent "allosteric scorpionand" complex visualizes a biological recognition event. ChemBioChem, 14(2), 224-229. [More Information]
Yu, M., Lim, N., Ellis, S., Nagase, H., Triccas, J., Rutledge, P., Todd, M. (2013). Incorporation of bulky and cationic cyclam-triazole moieties into marimastat can generate potent MMP inhibitory activity without inducing cytotoxicity. ChemistryOpen, 2(3), 99-105. [More Information]
Dungan, V., Poon, B., Barrett, E., Rutledge, P. (2013). L-Proline derived mimics of the non-haem iron active site catalyse allylic oxidation in acetonitrile solutions. Tetrahedron Letters, 54(10), 1236-1238. [More Information]
Cheung, S., McCarl, V., Holmes, A., Coleman, N., Rutledge, P. (2013). Substrate range and enantioselectivity of epoxidation reactions mediated by the ethene-oxidising Mycobacterium strain NBB4. Applied Microbiology and Biotechnology, 97(3), 1131-1140. [More Information]
Clifton, I., Ge, W., Adlington, R., Baldwin, J., Rutledge, P. (2013). The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site. FEBS Letters, 587(16), 2705-2709. [More Information]
Daruzzaman, A., Clifton, I., Adlington, R., Baldwin, J., Rutledge, P. (2013). The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue. Archives of Biochemistry and Biophysics, 530(1), 48-53. [More Information]
Daruzzaman, A., Clifton, I., Adlington, R., Baldwin, J., Rutledge, P. (2013). The Interaction of Isopenicillin N Synthase with Homologated Substrate Analogues delta-(L-alpha-Aminoadipoyl)-L-homocysteinyl-D-Xaa Characterised by Protein Crystallography. ChemBioChem, 14(5), 599-606. [More Information]
Dungan, V., Mueller-Bunz, H., Rutledge, P. (2012). (2S,4S)-3-benzoyl-4-benzyl-2-tert-butyl-1,3-oxazolidin-5-one. Acta Crystallographica. Section E: Structure Reports Online, 68(9). [More Information]
Beare, K., Coster, M., Rutledge, P. (2012). Diketoacid Inhibitors of HIV-1 Integrase: From L-708,906 to Raltegravir and Beyond. Current Medicinal Chemistry, 19(8), 1177-1192. [More Information]
Barry, S., Mueller-Bunz, H., Rutledge, P. (2012). Investigating the oxidation of alkenes by non-heme iron enzyme mimics. Organic and Biomolecular Chemistry, 10(36), 7372-7381. [More Information]
Dungan, V., Wong, S., Barry, S., Rutledge, P. (2012). L-proline-derived ligands to mimic the '2-His-1-carboxylate' triad of the non-haem iron oxidase active site. Tetrahedron, 68(15), 3231-3236. [More Information]
Ast, S., Rutledge, P., Todd, M. (2012). Reversing the triazole topology in a cyclam-triazole-dye ligand gives a 10-fold brighter signal response to Zn(2+) in aqueous solution. European Journal of Inorganic Chemistry, 2012 (34), 5611-5615. [More Information]
Lau, Y., Price, J., Todd, M., Rutledge, P. (2011). A Click Fluorophore Sensor that Can Distinguish Cu(II) and Hg(II) via Selective Anion-Induced Demetallation. Chemistry - A European Journal, 17(10), 2850-2858. [More Information]
Bridgeman, A., Rutledge, P., Todd, M., Connor, R. (2011). A treasure hunt for chemistry. Journal of Chemical Education, 88(4), 437-439. [More Information]
Lau, Y., Rutledge, P., Watkinson, M., Todd, M. (2011). Chemical sensors that incorporate click-derived triazoles. Chemical Society Reviews, 40(5), 2848-2866. [More Information]
Yu, M., Price, J., Jensen, P., Lovitt, C., Shelper, T., Duffy, S., Windus, L., Avery, V., Rutledge, P., Todd, M. (2011). Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic. Inorganic Chemistry, 50(24), 12823-12835. [More Information]
Clifton, I., Ge, W., Adlington, R., Baldwin, J., Rutledge, P. (2011). Isopenicillin N synthase binds delta-(L-alpha-aminoadipolyl)-L-Cysteinyl-D-thia-allo-Isoleucine through both Sulfur Atoms. ChemBioChem, 12(12), 1881-1885. [More Information]
Lo, A., Salam, N., Hibbs, D., Rutledge, P., Todd, M. (2011). Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal. PloS One, 6(5), e17446-1-e17446-13. [More Information]
Hosseini, S., Bhadbhade, M., Clarke, R., Rutledge, P., Rendina, L. (2011). Synthesis, carbohydrate- and DNA-binding studies of cationic 2,2':6',2"-terpyridineplatinum(II) complexes containing N- and S-donor boronic acid ligands. Dalton Transactions, 40(2), 506-513. [More Information]
Scully, C., Lau, Y., Jensen, P., Rutledge, P. (2011). Synthesis, electrochemistry and metal binding properties of monosubstituted ferrocenoyl peptides with thioether-containing sidechains. Journal of Organometallic Chemistry, 696(3), 715-721. [More Information]
Clifton, I., Ge, W., Adlington, R., Baldwin, J., Rutledge, P. (2011). The crystal structure of isopenicillin N synthase with delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-methionine reveals thioether coordination to iron. Archives of Biochemistry and Biophysics, 516(2), 103-107. [More Information]
Morrison, D., Issa, F., Bhadbhade, M., Groebler, L., Witting, P., Kassiou, M., Rutledge, P., Rendina, L. (2010). Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake. Journal of Biological Inorganic Chemistry, 15(8), 1305-1318. [More Information]
Ge, W., Clifton, I., Stok, J., Adlington, R., Baldwin, J., Rutledge, P. (2010). Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase. Biochemical and Biophysical Research Communications, 398(4), 659-664. [More Information]
Dungan, V., Ortin, Y., Mueller-Bunz, H., Rutledge, P. (2010). Design and synthesis of a tetradentate '3-amine-1-carboxylate' ligand to mimic the metal binding environment at the non-heme iron(II) oxidase active site. Organic and Biomolecular Chemistry, 8(7), 1666-1673. [More Information]
Manos-Turvey, A., Bulloch, E., Rutledge, P., Baker, E., Lott, J., Payne, R. (2010). Inhibition studies of mycobacterium tuberculosis salicylate synthase (Mbtl). ChemMedChem: chemistry enabling drug discovery, 5(7), 1067-1079. [More Information]
Scully, C., Rutledge, P. (2010). Synthesis and electrochemical studies of disubstituted ferrocene/dipeptide conjugates with sulfur-containing side chains. Tetrahedron, 66(30), 5653-5659. [More Information]
Ge, W., Clifton, I., Stok, J., Adlington, R., Baldwin, J., Rutledge, P. (2010). The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase. Organic and Biomolecular Chemistry, 8(1), 122-127. [More Information]
Rutledge, P. (2009). Profile: Science in Sydney. Chemistry World, 6(9).
Ge, W., Clifton, I., Howard-Jones, A., Stok, J., Adlington, R., Baldwin, J., Rutledge, P. (2009). Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue. ChemBioChem, 10(12), 2025-2031. [More Information]
Barry, S., Rutledge, P. (2008). cis-Dihydroxylation of Alkenes by a Non-Heme Iron Enzyme Mimic. Synlett, 2008 (14), 2172-2174. [More Information]
Ge, W., Clifton, I., Stok, J., Adlington, R., Baldwin, J., Rutledge, P. (2008). Isopenicillin N Synthase Mediates Thiolate Oxidation to Sulfenate in a Depsipeptide Substrate Analogue: Implications for Oxygen Binding and a Link to Nitrile Hydratase? Journal of the American Chemical Society, 130(31), 10096-10102. [More Information]
Scully, C., Jensen, P., Rutledge, P. (2008). Mercury binding by ferrocenoyl peptides with sulfur-containing side chains: Electrochemical, spectroscopic and structural studies. Journal of Organometallic Chemistry, 693(17), 2869-2876. [More Information]
Barry, S., Mueller-Bunz, H., Rutledge, P. (2008). tert-Butyldimethylsilanol hemihydrate. Acta Crystallographica. Section E: Structure Reports Online, E64(2008), o1174-U3051. [More Information]
Stewart, A., Clifton, I., Adlington, R., Baldwin, J., Rutledge, P. (2007). A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase. ChemBioChem, 8(16), 2003-2007. [More Information]
Howard-Jones, A., Elkins, J., Clifton, I., Roach, P., Adlington, R., Baldwin, J., Rutledge, P. (2007). Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight. Biochemistry, 46(16), 4755-4762. [More Information]
Murphy, P., Rutledge, P. (2006). Symbiosis in chemistry and biology. Nature Chemical Biology, 2(2), 59-62. [More Information]
Daruzzaman, A., Clifton, I., Adlington, R., Baldwin, J., Rutledge, P. (2006). Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase. ChemBioChem, 7(2), 351-358. [More Information]
Krall, J., Rutledge, P., Baldwin, J. (2005). Design and synthesis of an isopenicillin N synthase mimic. Tetrahedron, 61, 137-143. [More Information]
Long, A., Clifton, I., Roach, P., Baldwin, J., Rutledge, P., Schofield, C. (2005). Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-apha-aminoadipoyl)-L-cysteinyl-D-alanine. Biochemistry, 44(17), 6619-6628. [More Information]
Howard-Jones, A., Rutledge, P., Clifton, I., Adlington, R., Baldwin, J. (2005). Unique binding of a non-natural L,L,L-substrate by isopenicillin N synthase. Biochemical and Biophysical Research Communications, 336, 702-708. [More Information]
Grummitt, A., Rutledge, P., Clifton, I., Baldwin, J. (2004). Active-site-mediated elimination of hydrogen fluoride from a fluorinated substrate analogue by isopenicillin N synthase. Biochemical Journal, 382(2), 659-666. [More Information]
Elkins, J., Rutledge, P., Burzlaff, N., Clifton, I., Adlington, R., Roach, P., Baldwin, J. (2003). Crystallographic studies on the reaction of isopenicillin N synthase with an unsaturated substrate analogue. Organic and Biomolecular Chemistry, 1, 1455-1460. [More Information]
Long, A., Clifton, I., Roach, P., Baldwin, J., Schofield, C., Rutledge, P. (2003). Structural studies on the reaction of isopenicillin N synthase with the substrate analogue Î´-(L-Î±-aminoadipoyl)-L-cysteinyl-D-Î±-aminobutyrate. Biochemical Journal, 372(3), 687-693. [More Information]
Ferguson, A., Adlington, R., Martyres, D., Rutledge, P., Cowley, A., Baldwin, J. (2003). Total synthesis of a novel 2-thiabicyclo[3.2.0]heptan-6-one analogue of penicillin N. Tetrahedron, 59, 8233-8243. [More Information]
Rutledge, P., Burzlaff, N., Elkins, J., Pickford, M., Baldwin, J., Roach, P. (2002). A device for the high-pressure oxygenation of protein crystals. Analytical Biochemistry, 308, 265-268. [More Information]
Ogle, J., Clifton, I., Rutledge, P., Elkins, J., Burzlaff, N., Adlington, R., Roach, P., Baldwin, J. (2001). Alternative oxidation by isopenicillin N synthase observed by X-ray diffraction. Chemistry and Biology, 8(12), 1231-1237.
Hamilton, C., Yasuhara, A., Baldwin, J., Lloyd, M., Rutledge, P. (2001). Contrasting fates for 6-alpha-methylpenicillin N upon oxidation by deacetoxycephalosprin C synthase (DAOCS) and deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS). Bioorganic and Medicinal Chemistry Letters, 11(0), 2511-2514.
Burzlaff, N., Rutledge, P., Clifton, I., Hensgens, C., Pickford, M., Adlington, R., Roach, P., Baldwin, J. (1999). The reaction cycle of isopenicillin N synthase observed by X-ray diffraction. Nature, 401(6754, 14 October 1999), 721-724. [More Information]

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Conferences

George-Williams, S., Chiarovano, E., MacDougall, H., Rutledge, P., Pullen, R., Schmid, S., Verstraten, F. (2019). Investigating the use of Virtual Reality in teaching Chemistry to undergraduate students. The Australian Conference on Science and Mathematics Education (ACSME 2019), Brisbane: The University of Queensland.
Hossain, M., Yu, Z., Canning, J., Ast, S., Wong, J., Rutledge, P., Crossley, M., Jamalipour, A. (2016). Temperature Controlled Portable Smartphone Fluorimeter. The 6th Asia Pacific Optical Sensors Conference, Shanghai: OSA (Optical Society America). [More Information]
Hossain, M., Canning, J., Cook, K., Ast, S., Rutledge, P., Jamalipour, A. (2015). Absorption and fluorescence spectroscopy on a smartphone. Fifth Asia-Pacific Optical Sensors Conference (APOS 2015), Washington, USA: SPIE - International Society for Optical Engineering. [More Information]
Hossain, M., Ast, S., Canning, J., Cook, K., Rutledge, P., Jamalipour, A. (2015). Fluorescent measurements of Zn2+ on a smartphone. Fifth Asia-Pacific Optical Sensors Conference (APOS 2015), Washington, USA: SPIE - International Society for Optical Engineering. [More Information]
Hossain, M., Canning, J., Ast, S., Yen, T., Rutledge, P., Jamalipour, A. (2014). A smartphone fluorometer - the lab-in-a-phone. Optical Sensors 2014, Bellingham: Optical Society of America. [More Information]
Hossain, M., Canning, J., Ast, S., Rutledge, P., Webster, R., Jamalipour, A. (2014). Centralised and portable "network forensics" using smartphone-based diagnostics: Case Study - the mapping of tap water pH across Sydney, Australia. 2014 IEEE Photonics Conference, IPC 2014, Piscataway, USA: Institute of Electrical and Electronics Engineers (IEEE). [More Information]

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By Year

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2024

Xie, S., Wang, Y., Morton, C., Metcalfe, R., Dogovski, C., Pasaje, C., Dunn, E., Luth, M., Kumpornsin, K., Istvan, E., Rutledge, P., et al (2024). Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Nature Communications, 15(1). [More Information]

2023

Preston, C., Golumbic, Y., Kenneally, C., Phway, T., Rutledge, P., Martin, J., Braz Sousa, L., Motion, A. (2023). Citizen science in schools - Perceptions of project leaders and teachers. Teaching Science, 69(3), 22-35.
Scroggie, K., Burrell-Sander, K., Rutledge, P., Motion, A. (2023). GitHub as an open electronic laboratory notebook for real-time sharing of knowledge and collaboration. Digital Discovery, 2(4), 1188-1196. [More Information]
Golumbic, Y., Scroggie, K., Kenneally, C., Lin, J., Blyth, M., Firmer, G., Rutledge, P., Motion, A. (2023). Meet the Medicines—A Crowdsourced Approach to Collecting and Communicating Information about Essential Medicines Online. International Journal of Environmental Research and Public Health, 20(5). [More Information]
Motion, A., Golumbic, Y., Pullen, R., Rutledge, P. (2023). One-Line Stories as Connections Between Slides. In Susan Rowland, Louise Kuchel (Eds.), Teaching Science Students to Communicate: A Practical Guide, (pp. 331-335). Switzerland: Springer Nature Switzerland. [More Information]
Ball, S., Adamson, J., Sullivan, M., Zimmermann, M., Lo, V., Sanz-Hernandez, M., Jiang, X., Kwan, A., McKenzie, A., Werry, E., Kassiou, M., Rutledge, P., Sunde, M., et al (2023). Perphenazine-Macrocycle Conjugates Rapidly Sequester the Aβ42 Monomer and Prevent Formation of Toxic Oligomers and Amyloid. ACS Chemical Neuroscience, 14(1), 87-98. [More Information]
Lacey, H., Chen, R., Vuong, D., Lacey, E., Rutledge, P., Chooi, Y., Piggott, A., Booth, T. (2023). Resorculins: hybrid polyketide macrolides from Streptomyces sp. MST-91080. Organic and Biomolecular Chemistry, 21(12), 2531-2538. [More Information]

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2022

Smith, N., Quan, D., Nagalingam, G., Triccas, J., Rendina, L., Rutledge, P. (2022). Carborane clusters increase the potency of bis-substituted cyclam derivatives against Mycobacterium tuberculosis. RSC Medicinal Chemistry, 13(10), 1234-1238. [More Information]
Lacey, H., Rutledge, P. (2022). Recently Discovered Secondary Metabolites from Streptomyces Species. Molecules, 27(3), 887. [More Information]
Lacey, H., Chen, R., Vuong, D., Fisher, M., Lacey, E., Rutledge, P., Piggott, A. (2022). Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3. The Journal of Antibiotics, 75(9), 483-490. [More Information]
Lacey, H., Chen, R., Vuong, D., Cowled, M., Lacey, E., Rutledge, P., Piggott, A. (2022). Yeppoonic acids A-D: 1,2,4-trisubstituted arene carboxylic acid co-metabolites of conglobatin from an Australian Streptomyces sp. The Journal of Antibiotics, 75(2), 108-112. [More Information]

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2021

Counsell, A., Yu, M., Shi, M., Jones, A., Batten, J., Turner, P., Todd, M., Rutledge, P. (2021). Copper(ii) complexes ofN-propargyl cyclam ligands reveal a range of coordination modes and colours, and unexpected reactivity. Dalton Transactions, 50(11), 3931-3942. [More Information]
Chapman, N., Rutledge, P. (2021). Isopenicillin N Synthase: Crystallographic Studies. ChemBioChem, 22(10), 1687-1705. [More Information]

2020

George-Williams, S., Motion, A., Pullen, R., Rutledge, P., Schmid, S., Wilkinson, S. (2020). Chemistry in the Time of COVID-19: Reflections on a Very Unusual Semester. Journal of Chemical Education. [More Information]
Lacey, H., Booth, T., Vuong, D., Rutledge, P., Lacey, E., Chooi, Y., Piggott, A. (2020). Conglobatins B-E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin. The Journal of Antibiotics, 73(11), 756-765. [More Information]
Frei, A., Zuegg, J., Elliott, A., Baker, M., Braese, S., Brown, C., Chen, F., G. Dowson, C., Dujardin, G., Jung, N., Renfrew, A., Rutledge, P., Todd, M., et al (2020). Metal complexes as a promising source for new antibiotics. Chemical Science, 11(10), 2627-2639. [More Information]
Korsik, M., Tse, E., Smith, D., Lewis, W., Rutledge, P., Todd, M. (2020). tele-Substitution Reactions in the Synthesis of a Promising Class of 1,2,4-Triazolo[4,3- a]pyrazine-Based Antimalarials. The Journal of Organic Chemistry, 85(21), 13438-13452. [More Information]

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2019

Quan, D., Nagalingam, G., Luck, I., Proschogo, N., Pillalamarri, V., Addlagatta, A., Martinez, E., Sintchenko, V., Rutledge, P., Triccas, J. (2019). Bengamides display potent activity against drug-resistant Mycobacterium tuberculosis. Scientific Reports, 9(1), 14396. [More Information]
George-Williams, S., Chiarovano, E., MacDougall, H., Rutledge, P., Pullen, R., Schmid, S., Verstraten, F. (2019). Investigating the use of Virtual Reality in teaching Chemistry to undergraduate students. The Australian Conference on Science and Mathematics Education (ACSME 2019), Brisbane: The University of Queensland.
Lacey, H., Gilchrist, C., Crombie, A., Kalaitzis, J., Vuong, D., Rutledge, P., Turner, P., Pitt, J., Lacey, E., Chooi, Y., et al (2019). Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis. Beilstein Journal of Organic Chemistry, 15, 2631-2643. [More Information]

2018

Spain, M., Wong, J., Nagalingam, G., Batten, J., Hortle, E., Oehlers, S., Jiang, X., Murage, H., Orford, J., Crisologo, P., Triccas, J., Rutledge, P., Todd, M. (2018). Antitubercular bis-substituted cyclam derivatives: Structure-activity relationships and in vivo studies. Journal of Medicinal Chemistry, 61(8), 3595-3608. [More Information]
Guardia, A., Baiget, J., Cacho, M., Perez, A., Ortega-Guerra, M., Nxumalo, W., Khanye, S., Rullas, J., Ortega, F., Jimenez, E., Osende, J., Badiola, K., Rutledge, P., Todd, M., et al (2018). Easy-to-synthesize spirocyclic compounds possess remarkable in vivo activity against Mycobacterium tuberculosis. Journal of Medicinal Chemistry, 61(24), 11327-11340. [More Information]
Lau, Y., Clegg, J., Price, J., Macquart, R., Todd, M., Rutledge, P. (2018). Molecular Switches for any pH: A Systematic Study of the Versatile Coordination Behaviour of Cyclam Scorpionands. Chemistry - A European Journal, 24(7), 1573-1585. [More Information]

2017

Devi, P., Rutledge, P. (2017). Cyclobutanone analogues of (Beta)-lactam antibiotics: (Beta)-lactamase inhibitors with untapped potential? ChemBioChem, 18(4), 338-351. [More Information]
Wong, J., Todd, M., Rutledge, P. (2017). Recent advances in macrocyclic fluorescent probes for ion sensing. Molecules, 22(2), 1-28. [More Information]
Wong, J., Proschogo, N., Todd, M., Rutledge, P. (2017). Selective displacement of a scorpionand triazole ligand from metallocyclam complexes visualised with NMR spectroscopy. European Journal of Inorganic Chemistry, 2017 (7), 1075-1086. [More Information]
McNeill, L., Brown, T., Sami, M., Clifton, I., Burzlaff, N., Claridge, T., Adlington, R., Baldwin, J., Rutledge, P., Schofield, C. (2017). Terminally truncated isopenicillin N synthase generates a dithioester product: Evidence for a thioaldehyde intermediate during catalysis and a new mode of reaction for non-heme iron oxidases. Chemistry - A European Journal, 23(52), 12815-12824. [More Information]
Hossain, M., Canning, J., Yu, Z., Ast, S., Rutledge, P., Wong, J., Jamalipour, A., Crossley, M. (2017). Time-resolved and temperature tuneable measurements of fluorescent intensity using a smartphone fluorimeter. Analyst, 142(11), 1953-1961. [More Information]

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2016

Counsell, A., Jones, A., Todd, M., Rutledge, P. (2016). A direct method for the N-tetraalkylation of azamacrocycles. Beilstein Journal of Organic Chemistry, 12, 2457-2461. [More Information]
Yu, M., Nagalingam, G., Ellis, S., Martinez, E., Sintchenko, V., Spain, M., Rutledge, P., Todd, M., Triccas, J. (2016). Nontoxic metal-cyclam complexes, a new class of compounds with potency against drug-resistant Mycobacterium tuberculosis. Journal of Medicinal Chemistry, 59(12), 5917-5921. [More Information]
Wong, J., Ast, S., Yu, M., Flehr, R., Counsell, A., Turner, P., Crisologo, P., Todd, M., Rutledge, P. (2016). Synthesis and evaluation of 1,8-disubstituted-cyclam/naphthalimide conjugates as probes for metal ions. ChemistryOpen, 5(4), 375-385. [More Information]
Hossain, M., Yu, Z., Canning, J., Ast, S., Wong, J., Rutledge, P., Crossley, M., Jamalipour, A. (2016). Temperature Controlled Portable Smartphone Fluorimeter. The 6th Asia Pacific Optical Sensors Conference, Shanghai: OSA (Optical Society America). [More Information]

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2015

Hossain, M., Canning, J., Cook, K., Ast, S., Rutledge, P., Jamalipour, A. (2015). Absorption and fluorescence spectroscopy on a smartphone. Fifth Asia-Pacific Optical Sensors Conference (APOS 2015), Washington, USA: SPIE - International Society for Optical Engineering. [More Information]
Canning, J., Ast, S., Hossain, M., Chan, H., Rutledge, P., Jamalipour, A. (2015). Bend and twist intramolecular charge transfer and emission for selective metal ion sensing. Optical Materials Express, 5(11), 2675-2681. [More Information]
Hossain, M., Canning, J., Ast, S., Cook, K., Rutledge, P., Jamalipour, A. (2015). Combined "dual" absorption and fluorescence smartphone spectrometers. Optics Letters, 40(8), 1737-1740. [More Information]
Rutledge, P., Challis, G. (2015). Discovery of microbial natural products by activation of silent biosynthetic gene clusters. Nature Reviews Microbiology, 13(8), 509-523. [More Information]
Hossain, M., Canning, J., Ast, S., Rutledge, P., Jamalipour, A. (2015). Early Warning Smartphone Diagnostics for Water Security and Analysis Using Real-Time pH Mapping. Photonic Sensors, 5(4), 289-297. [More Information]
Yu, M., Wong, J., Tang, C., Turner, P., Todd, M., Rutledge, P. (2015). Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Bronsted acids. Beilstein Journal of Organic Chemistry, 11, 37-41. [More Information]
Hossain, M., Ast, S., Canning, J., Cook, K., Rutledge, P., Jamalipour, A. (2015). Fluorescent measurements of Zn2+ on a smartphone. Fifth Asia-Pacific Optical Sensors Conference (APOS 2015), Washington, USA: SPIE - International Society for Optical Engineering. [More Information]
Porter, D., Poon, B., Rutledge, P. (2015). Iron complexes of tetramine ligands catalyse allylic hydroxy-amination via a nitroso-ene mechanism. Beilstein Journal of Organic Chemistry, 11, 2549-2556. [More Information]
Rutledge, P. (2015). Isopenicillin N Synthase. In Robert P. Hausinger, Christopher J. Schofield (Eds.), 2-Oxoglutarate-Dependent Oxygenases, (pp. 414-424). Cambridge: RSC Publishing. [More Information]
Hossain, M., Canning, J., Ast, S., Rutledge, P., Yen, T., Jamalipour, A. (2015). Lab-in-a-phone: Smartphone-based portable fluorometer for pH measurements of environmental water. IEEE Sensors Journal, 15(9), 5095-5102. [More Information]
Devi, P., Barry, S., Houlihan, K., Murphy, M., Turner, P., Jensen, P., Rutledge, P. (2015). Synthesis and structural characterisation of amides from picolinic acid and pyridine-2,6-dicarboxylic acid. Scientific Reports, 9, 1-6. [More Information]
Ast, S., Kuke, S., Rutledge, P., Todd, M. (2015). Using click chemistry to tune the properties and the fluorescence response mechanism of structurally similar probes for metal ions. European Journal of Inorganic Chemistry, 2015 (1), 58-66. [More Information]

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2014

Hossain, M., Canning, J., Ast, S., Yen, T., Rutledge, P., Jamalipour, A. (2014). A smartphone fluorometer - the lab-in-a-phone. Optical Sensors 2014, Bellingham: Optical Society of America. [More Information]
Byrne, C., Houlihan, K., Devi, P., Jensen, P., Rutledge, P. (2014). Bio-inspired nitrile hydration by peptidic ligands based on L-cysteine, L-methionine or L-penicillamine and pyridine-2,6-dicarboxylic acid. Molecules, 19(12), 20751-20767. [More Information]
Hossain, M., Canning, J., Ast, S., Rutledge, P., Webster, R., Jamalipour, A. (2014). Centralised and portable "network forensics" using smartphone-based diagnostics: Case Study - the mapping of tap water pH across Sydney, Australia. 2014 IEEE Photonics Conference, IPC 2014, Piscataway, USA: Institute of Electrical and Electronics Engineers (IEEE). [More Information]
Yu, M., Ast, S., Yu, Q., Lo, A., Flehr, R., Todd, M., Rutledge, P. (2014). Incorporating a piperidinyl group in the fluorophore extends the fluorescence lifetime of click-derived cyclam-naphthalimide conjugates. PloS One, 9(7), 1-12. [More Information]
Yu, M., Ryan, T., Ellis, S., Bush, A., Triccas, J., Rutledge, P., Todd, M. (2014). Neuroprotective peptide-macrocycle conjugates reveal complex structure-activity relationships in their interactions with amyloid beta. Metallomics, 6(10), 1931-1940. [More Information]
Ast, S., Rutledge, P., Todd, M. (2014). pH-Responsive quantum dots (RQDs) that combine a fluorescent nanoparticle with a pH-sensitive dye. Physical Chemistry Chemical Physics, 16(46), 25255-25257. [More Information]
Ast, S., Rutledge, P., Todd, M. (2014). The properties and performance of a pH-responsive functionalised nanoparticle. Faraday Discussions, 175, 171-187. [More Information]

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2013

Yu, M., Yu, Q., Rutledge, P., Todd, M. (2013). A fluorescent "allosteric scorpionand" complex visualizes a biological recognition event. ChemBioChem, 14(2), 224-229. [More Information]
Yu, M., Lim, N., Ellis, S., Nagase, H., Triccas, J., Rutledge, P., Todd, M. (2013). Incorporation of bulky and cationic cyclam-triazole moieties into marimastat can generate potent MMP inhibitory activity without inducing cytotoxicity. ChemistryOpen, 2(3), 99-105. [More Information]
Dungan, V., Poon, B., Barrett, E., Rutledge, P. (2013). L-Proline derived mimics of the non-haem iron active site catalyse allylic oxidation in acetonitrile solutions. Tetrahedron Letters, 54(10), 1236-1238. [More Information]
Cheung, S., McCarl, V., Holmes, A., Coleman, N., Rutledge, P. (2013). Substrate range and enantioselectivity of epoxidation reactions mediated by the ethene-oxidising Mycobacterium strain NBB4. Applied Microbiology and Biotechnology, 97(3), 1131-1140. [More Information]
Clifton, I., Ge, W., Adlington, R., Baldwin, J., Rutledge, P. (2013). The crystal structure of an isopenicillin N synthase complex with an ethereal substrate analogue reveals water in the oxygen binding site. FEBS Letters, 587(16), 2705-2709. [More Information]
Daruzzaman, A., Clifton, I., Adlington, R., Baldwin, J., Rutledge, P. (2013). The crystal structure of isopenicillin N synthase with a dipeptide substrate analogue. Archives of Biochemistry and Biophysics, 530(1), 48-53. [More Information]
Daruzzaman, A., Clifton, I., Adlington, R., Baldwin, J., Rutledge, P. (2013). The Interaction of Isopenicillin N Synthase with Homologated Substrate Analogues delta-(L-alpha-Aminoadipoyl)-L-homocysteinyl-D-Xaa Characterised by Protein Crystallography. ChemBioChem, 14(5), 599-606. [More Information]

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2012

Dungan, V., Mueller-Bunz, H., Rutledge, P. (2012). (2S,4S)-3-benzoyl-4-benzyl-2-tert-butyl-1,3-oxazolidin-5-one. Acta Crystallographica. Section E: Structure Reports Online, 68(9). [More Information]
Beare, K., Coster, M., Rutledge, P. (2012). Diketoacid Inhibitors of HIV-1 Integrase: From L-708,906 to Raltegravir and Beyond. Current Medicinal Chemistry, 19(8), 1177-1192. [More Information]
Barry, S., Mueller-Bunz, H., Rutledge, P. (2012). Investigating the oxidation of alkenes by non-heme iron enzyme mimics. Organic and Biomolecular Chemistry, 10(36), 7372-7381. [More Information]
Dungan, V., Wong, S., Barry, S., Rutledge, P. (2012). L-proline-derived ligands to mimic the '2-His-1-carboxylate' triad of the non-haem iron oxidase active site. Tetrahedron, 68(15), 3231-3236. [More Information]
Ast, S., Rutledge, P., Todd, M. (2012). Reversing the triazole topology in a cyclam-triazole-dye ligand gives a 10-fold brighter signal response to Zn(2+) in aqueous solution. European Journal of Inorganic Chemistry, 2012 (34), 5611-5615. [More Information]

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2011

Lau, Y., Price, J., Todd, M., Rutledge, P. (2011). A Click Fluorophore Sensor that Can Distinguish Cu(II) and Hg(II) via Selective Anion-Induced Demetallation. Chemistry - A European Journal, 17(10), 2850-2858. [More Information]
Bridgeman, A., Rutledge, P., Todd, M., Connor, R. (2011). A treasure hunt for chemistry. Journal of Chemical Education, 88(4), 437-439. [More Information]
Lau, Y., Rutledge, P., Watkinson, M., Todd, M. (2011). Chemical sensors that incorporate click-derived triazoles. Chemical Society Reviews, 40(5), 2848-2866. [More Information]
Yu, M., Price, J., Jensen, P., Lovitt, C., Shelper, T., Duffy, S., Windus, L., Avery, V., Rutledge, P., Todd, M. (2011). Copper, nickel, and zinc cyclam-amino acid and cyclam-peptide complexes may be synthesized with "click" chemistry and are noncytotoxic. Inorganic Chemistry, 50(24), 12823-12835. [More Information]
Clifton, I., Ge, W., Adlington, R., Baldwin, J., Rutledge, P. (2011). Isopenicillin N synthase binds delta-(L-alpha-aminoadipolyl)-L-Cysteinyl-D-thia-allo-Isoleucine through both Sulfur Atoms. ChemBioChem, 12(12), 1881-1885. [More Information]
Lo, A., Salam, N., Hibbs, D., Rutledge, P., Todd, M. (2011). Polyamide-Scorpion Cyclam Lexitropsins Selectively Bind AT-Rich DNA Independently of the Nature of the Coordinated Metal. PloS One, 6(5), e17446-1-e17446-13. [More Information]
Hosseini, S., Bhadbhade, M., Clarke, R., Rutledge, P., Rendina, L. (2011). Synthesis, carbohydrate- and DNA-binding studies of cationic 2,2':6',2"-terpyridineplatinum(II) complexes containing N- and S-donor boronic acid ligands. Dalton Transactions, 40(2), 506-513. [More Information]
Scully, C., Lau, Y., Jensen, P., Rutledge, P. (2011). Synthesis, electrochemistry and metal binding properties of monosubstituted ferrocenoyl peptides with thioether-containing sidechains. Journal of Organometallic Chemistry, 696(3), 715-721. [More Information]
Clifton, I., Ge, W., Adlington, R., Baldwin, J., Rutledge, P. (2011). The crystal structure of isopenicillin N synthase with delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-methionine reveals thioether coordination to iron. Archives of Biochemistry and Biophysics, 516(2), 103-107. [More Information]

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2010

Morrison, D., Issa, F., Bhadbhade, M., Groebler, L., Witting, P., Kassiou, M., Rutledge, P., Rendina, L. (2010). Boronated phosphonium salts containing arylboronic acid, closo-carborane, or nido-carborane: synthesis, X-ray diffraction, in vitro cytotoxicity, and cellular uptake. Journal of Biological Inorganic Chemistry, 15(8), 1305-1318. [More Information]
Ge, W., Clifton, I., Stok, J., Adlington, R., Baldwin, J., Rutledge, P. (2010). Crystallographic studies on the binding of selectively deuterated LLD- and LLL-substrate epimers by isopenicillin N synthase. Biochemical and Biophysical Research Communications, 398(4), 659-664. [More Information]
Dungan, V., Ortin, Y., Mueller-Bunz, H., Rutledge, P. (2010). Design and synthesis of a tetradentate '3-amine-1-carboxylate' ligand to mimic the metal binding environment at the non-heme iron(II) oxidase active site. Organic and Biomolecular Chemistry, 8(7), 1666-1673. [More Information]
Manos-Turvey, A., Bulloch, E., Rutledge, P., Baker, E., Lott, J., Payne, R. (2010). Inhibition studies of mycobacterium tuberculosis salicylate synthase (Mbtl). ChemMedChem: chemistry enabling drug discovery, 5(7), 1067-1079. [More Information]
Scully, C., Rutledge, P. (2010). Synthesis and electrochemical studies of disubstituted ferrocene/dipeptide conjugates with sulfur-containing side chains. Tetrahedron, 66(30), 5653-5659. [More Information]
Ge, W., Clifton, I., Stok, J., Adlington, R., Baldwin, J., Rutledge, P. (2010). The crystal structure of an LLL-configured depsipeptide substrate analogue bound to isopenicillin N synthase. Organic and Biomolecular Chemistry, 8(1), 122-127. [More Information]

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2009

Rutledge, P. (2009). Profile: Science in Sydney. Chemistry World, 6(9).
Ge, W., Clifton, I., Howard-Jones, A., Stok, J., Adlington, R., Baldwin, J., Rutledge, P. (2009). Structural studies on the reaction of isopenicillin N synthase with a sterically demanding depsipeptide substrate analogue. ChemBioChem, 10(12), 2025-2031. [More Information]

2008

Barry, S., Rutledge, P. (2008). cis-Dihydroxylation of Alkenes by a Non-Heme Iron Enzyme Mimic. Synlett, 2008 (14), 2172-2174. [More Information]
Ge, W., Clifton, I., Stok, J., Adlington, R., Baldwin, J., Rutledge, P. (2008). Isopenicillin N Synthase Mediates Thiolate Oxidation to Sulfenate in a Depsipeptide Substrate Analogue: Implications for Oxygen Binding and a Link to Nitrile Hydratase? Journal of the American Chemical Society, 130(31), 10096-10102. [More Information]
Scully, C., Jensen, P., Rutledge, P. (2008). Mercury binding by ferrocenoyl peptides with sulfur-containing side chains: Electrochemical, spectroscopic and structural studies. Journal of Organometallic Chemistry, 693(17), 2869-2876. [More Information]
Barry, S., Mueller-Bunz, H., Rutledge, P. (2008). tert-Butyldimethylsilanol hemihydrate. Acta Crystallographica. Section E: Structure Reports Online, E64(2008), o1174-U3051. [More Information]

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2007

Stewart, A., Clifton, I., Adlington, R., Baldwin, J., Rutledge, P. (2007). A cyclobutanone analogue mimics penicillin in binding to isopenicillin N synthase. ChemBioChem, 8(16), 2003-2007. [More Information]
Howard-Jones, A., Elkins, J., Clifton, I., Roach, P., Adlington, R., Baldwin, J., Rutledge, P. (2007). Interactions of isopenicillin N synthase with cyclopropyl-containing substrate analogues reveal new mechanistic insight. Biochemistry, 46(16), 4755-4762. [More Information]

2006

Murphy, P., Rutledge, P. (2006). Symbiosis in chemistry and biology. Nature Chemical Biology, 2(2), 59-62. [More Information]
Daruzzaman, A., Clifton, I., Adlington, R., Baldwin, J., Rutledge, P. (2006). Unexpected oxidation of a depsipeptide substrate analogue in crystalline isopenicillin N synthase. ChemBioChem, 7(2), 351-358. [More Information]

2005

Krall, J., Rutledge, P., Baldwin, J. (2005). Design and synthesis of an isopenicillin N synthase mimic. Tetrahedron, 61, 137-143. [More Information]
Rutledge, P. (2005). Nitriles with a heteroatom attached to the cyanocarbon. In Alan R Katritzky and Richard JK Taylor (Eds.), Comprehensive organic functional group transformationsII, (pp. 1023-1080). UK: Pergamon Elsevier.
Long, A., Clifton, I., Roach, P., Baldwin, J., Rutledge, P., Schofield, C. (2005). Structural studies on the reaction of isopenicillin N synthase with the truncated substrate analogues delta-(L-apha-aminoadipoyl)-L-cysteinyl-D-alanine. Biochemistry, 44(17), 6619-6628. [More Information]
Howard-Jones, A., Rutledge, P., Clifton, I., Adlington, R., Baldwin, J. (2005). Unique binding of a non-natural L,L,L-substrate by isopenicillin N synthase. Biochemical and Biophysical Research Communications, 336, 702-708. [More Information]

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2004

Grummitt, A., Rutledge, P., Clifton, I., Baldwin, J. (2004). Active-site-mediated elimination of hydrogen fluoride from a fluorinated substrate analogue by isopenicillin N synthase. Biochemical Journal, 382(2), 659-666. [More Information]

2003

Elkins, J., Rutledge, P., Burzlaff, N., Clifton, I., Adlington, R., Roach, P., Baldwin, J. (2003). Crystallographic studies on the reaction of isopenicillin N synthase with an unsaturated substrate analogue. Organic and Biomolecular Chemistry, 1, 1455-1460. [More Information]
Long, A., Clifton, I., Roach, P., Baldwin, J., Schofield, C., Rutledge, P. (2003). Structural studies on the reaction of isopenicillin N synthase with the substrate analogue Î´-(L-Î±-aminoadipoyl)-L-cysteinyl-D-Î±-aminobutyrate. Biochemical Journal, 372(3), 687-693. [More Information]
Ferguson, A., Adlington, R., Martyres, D., Rutledge, P., Cowley, A., Baldwin, J. (2003). Total synthesis of a novel 2-thiabicyclo[3.2.0]heptan-6-one analogue of penicillin N. Tetrahedron, 59, 8233-8243. [More Information]

2002

Rutledge, P., Burzlaff, N., Elkins, J., Pickford, M., Baldwin, J., Roach, P. (2002). A device for the high-pressure oxygenation of protein crystals. Analytical Biochemistry, 308, 265-268. [More Information]

2001

Ogle, J., Clifton, I., Rutledge, P., Elkins, J., Burzlaff, N., Adlington, R., Roach, P., Baldwin, J. (2001). Alternative oxidation by isopenicillin N synthase observed by X-ray diffraction. Chemistry and Biology, 8(12), 1231-1237.
Hamilton, C., Yasuhara, A., Baldwin, J., Lloyd, M., Rutledge, P. (2001). Contrasting fates for 6-alpha-methylpenicillin N upon oxidation by deacetoxycephalosprin C synthase (DAOCS) and deacetoxy/deacetylcephalosporin C synthase (DAOC/DACS). Bioorganic and Medicinal Chemistry Letters, 11(0), 2511-2514.

1999

Burzlaff, N., Rutledge, P., Clifton, I., Hensgens, C., Pickford, M., Adlington, R., Roach, P., Baldwin, J. (1999). The reaction cycle of isopenicillin N synthase observed by X-ray diffraction. Nature, 401(6754, 14 October 1999), 721-724. [More Information]

Selected Grants

2024

Development of Advanced Radiochemical Technologies, Rendina L, Rutledge P, New E, Australian Research Council (ARC)/Industrial Transformation Training Centres (ITTC)

2022

Resurrecting Ancient Proteins to Unlock New Catalytic Activity, Rutledge P, Coleman N, Australian Research Council (ARC)/Discovery Projects (DP)

2020

CRFI-Prof. Peter Rutledge, Rutledge P, DVC Research/CRFI-Annie Trestain Bray - Bequest
Undermining fungal defences by targeting their functional amyloid armour, Sunde M, Kwan A, Rutledge P, Australian Research Council (ARC)/Discovery Projects (DP)

2017

Synthesis of fragment-like small molecule Student: Paul King, Rutledge P, Commonwealth Scientific and Industrial Research Organisation/CSIRO Flagship Postgraduate Scholarship

2015

An Open Source Approach to Understanding an Important Parasite Ion Pump, Rutledge P, Kirk K, Wells T, Australian Research Council (ARC)/Linkage Projects (LP)

2014

A new class of inhibitors for the treatment of tuberculosis, Triccas J, Rutledge P, West N, Todd M, National Health and Medical Research Council (NHMRC)/Project Grants
Inhalation Delivery Sysytem for Drug and Vaccine Delivery , Britton W, Chan H, Triccas J, Rutledge P, Traini D, DVC Research/Equipment Grant

2013

University of Sydney Automated Peptide Synthesis Platform, Payne R, Britton W, Byrne S, Chan H, Clarke R, Hunt N, Jolliffe K, Kassiou M, Lay P, Mackay J, Matthews J, McErlean C, New E, Rasmussen H, Rendina L, Rudrawar S, Rutledge P, Shepherd N, National Health and Medical Research Council (NHMRC)/Equipment Grant

2012

Charting Intercellular Space, Todd M, Rutledge P, Smith P, Australian Research Council (ARC)/Discovery Projects (DP)

2009

Target Activated Therapeutics: A New Strategy for Monitoring and Treating Breast Cancer, Todd M, Rutledge P, Sutherland R, Butt A, National Breast Cancer Foundation/Pilot Study Grants

2007

800 MHz NMR spectrometer for biomolecular structure function analysis, Ball G, Fazekas de St Groth B, Gell D, Graham R, Kuchel P, Mackay J, Matthews J, Messerle B, Otting G, Rutledge P, Shine J, Stock D, Trewhella J, Vadas M, Vandenberg J, Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF)
800 MHz NMR spectrometer for biomolecular structure-function analysis, Mackay J, Otting G, Kuchel P, Matthews J, Gell D, Trewhella J, Rutledge P, Messerle B, Vadas M, Graham R, Vandenberg J, Stock D, Ball G, Fazekas de St Groth B, Shine J, Australian Research Council (ARC)/Linkage Infrastructure, Equipment and Facilities (LIEF)

2006

Biologically Inspired Catalysts for Nitrile Hydration: New Tools for Synthesis and Bioremediation, Rutledge P, University of Sydney/Bridging Support

2005

An XAFS study of non-heme iron oxidase mimics, Rutledge P, Australian Nuclear Science and Technology Organisation/Australian Synchrotron Research Program
New catalysts for hydrocarbon oxidation, Rutledge P, University of Sydney/Early Career Researcher

2003

Peptide mimics of nitrile hydratases: crystallographic and mechanistic studies, Rutledge P, Science Foundation Ireland/Research Grant
Enzyme mimics for the bioremediation of nitrile pollutants, Rutledge P, University College Dublin/Presidentâ€™s Award for Research
Enzymes and enzyme mimics for the bioremediation of polycyclic aromatic hydrocarbons, Rutledge P, Irish Research Council for Science/Postgraduate Award

2002

Enzyme mimics for bioremediation and environmental reclamation, Rutledge P, Higher Education Authority (Ireland)/Program for Research in Third Level Institutions, Cycle 3 Grant

Honours project opportunities

Metal ion sensors for biology
Fluorescent imaging agents for cancer diagnostics
Biocatalysis and bio-inspired catalysis

Faculty of Science

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Professor Peter Rutledge

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2002

Honours project opportunities

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