People_

Associate Professor Rachel Tan

FightMND Mid-Career Research Fellow
School of Medical Sciences (Neuroscience)

Email

rachel.tan1@sydney.edu.au

Details

Member of The Centre for Drug Discovery Innovation

Member of the Brain and Mind Centre

Themes

Neurosciences and Mental Health

Keywords

Dementia, Motor neuron disease, Neurosciences, Nervous system diseases

Approaches

Pathogenesis, Pathology, Translational Research

Publications

By Type

Expand all

Journals

Timmins, H., Mok, V., Kim, S., Shahrizaila, N., Sung, J., Sobue, G., Agustini, S., Ward, S., Anstey, K., Talbot, D., Tu, S., Tan, R., Lin, C., O'Callaghan, C., Michaelian, J., Jeon, Y., Foxe, D., Naismith, S., Piguet, O., Ahmed, R., Devenney, E., Park, S., Kiernan, M., et al (2024). Regional health priorities for dementia: a roadmap for the Western Pacific. The Lancet Regional Health. Western Pacific, 50, 101179. [More Information]
Mazumder, S., McCann, H., D'Silva, S., Furlong, S., Shepherd, C., Kril, J., Halliday, G., Rowe, D., Kiernan, M., Tan, R. (2023). Riluzole is associated with decreasing neuritic plaque severity in amyotrophic lateral sclerosis. Brain, 146(3), e17-e19. [More Information]
Pinkerton, M., Fernandes Lourenco Dale, G., Pacheco, M., Halliday, G., Kiernan, M., Tan, R. (2023). Survival in sporadic ALS is associated with lower p62 burden in the spinal cord. Journal of Neuropathology and Experimental Neurology, 82(9), 769-773. [More Information]
Yang, Y., Rowe, D., McCann, H., Shepherd, C., Kril, J., Kiernan, M., Halliday, G., Tan, R. (2023). Treatment with the copper compound CuATSM has no significant effect on motor neuronal pathology in patients with ALS. Neuropathology and Applied Neurobiology, 49(4). [More Information]
Forrest, S., Kim, J., De Sousa, C., Cheong, R., Crockford, D., Sheedy, D., Stevens, J., McCrossin, T., Tan, R., McCann, H., Kiernan, M., Halliday, G., Kril, J., et al (2021). Coexisting Lewy body disease and clinical parkinsonism in amyotrophic lateral sclerosis. European Journal of Neurology, 28(7), 2192-2199. [More Information]
Forrest, S., Halliday, G., Sizemova, A., Van Roijen, M., McGinley, C., Bright, F., Kapur, M., McGeachie, A., McCann, H., Shepherd, C., Tan, R., Kril, J., et al (2020). A Practical Approach to Differentiate the Frontotemporal Tauopathy Subtypes. Journal of Neuropathology and Experimental Neurology, 79(10), 1122-1126. [More Information]
Tan, R., Halliday, G. (2020). Author response: The underacknowledged PPA-ALS: A unique clinicopathologic subtype with strong heritability. Neurology, 94(6), 283. [More Information]
Forrest, S., Crockford, D., Sizemova, A., McCann, H., Shepherd, C., McGeachie, A., Affleck, A., Carew-Jones, F., Bartley, L., Kwok, J., Kim, W., Jary, E., Tan, R., McGinley, C., Piguet, O., Hodges, J., Kril, J., Halliday, G. (2019). Coexisting Lewy body disease and clinical parkinsonism in frontotemporal lobar degeneration. Neurology, 92(21), e2472-e2482. [More Information]
Yang, Y., Halliday, G., Kiernan, M., Tan, R. (2019). TDP-43 levels in the brain tissue of ALS cases with and without C9ORF72 or ATXN2 gene expansions. Neurology, 93(19), e1748-e1755. [More Information]
Tan, R., Guennewig, B., Dobson-Stone, C., Kwok, J., Kril, J., Kiernan, M., Hodges, J., Piguet, O., Halliday, G. (2019). The underacknowledged PPA-ALS: A unique clinicopathologic subtype with strong heritability. Neurology, 92(12), e1354-e1366. [More Information]
Tan, R., Yang, Y., McCann, H., Shepherd, C., Halliday, G. (2019). Von Economo Neurons in Behavioral Variant Frontotemporal Dementia with Underlying Alzheimer's Disease. Journal of Alzheimer's Disease, 69(4), 963-967. [More Information]
Tan, R., Yang, Y., Halliday, G. (2018). Multiple neuronal pathologies are common in young patients with pathologically proven Frontotemporal lobar degeneration. Neuropathology and Applied Neurobiology, 44(5), 522-532. [More Information]
Guo, C., Tan, R., Hodges, J., Hu, X., Sami, S., Hornberger, M. (2018). Reply: The Crus exhibits stronger functional connectivity with executive network nodes than with the default mode network. Brain, 141(4), e25. [More Information]
Tan, R., Ke, Y., Ittner, L., Halliday, G. (2017). ALS/FTLD: experimental models and reality. Acta Neuropathologica, 133(2), 177-196. [More Information]
Tan, R., Kril, J., Yang, Y., Tom, N., Hodges, J., Villemagne, V., Rowe, C., Leyton, C., Kwok, J., Ittner, L., Halliday, G. (2017). Assessment of amyloid (beta) in pathologically confirmed frontotemporal dementia syndromes. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 9, 10-20. [More Information]
Gellersen, H., Guo, C., O'Callaghan, C., Tan, R., Sami, S., Hornberger, M. (2017). Cerebellar atrophy in neurodegeneration - a meta-analysis. Journal of Neurology, Neurosurgery and Psychiatry, 88(9), 780-788. [More Information]
Tan, R., Yang, Y., Kim, W., Dobson-Stone, C., Kwok, J., Kiernan, M., Halliday, G. (2017). Distinct TDP-43 inclusion morphologies in frontotemporal lobar degeneration with and without amyotrophic lateral sclerosis. Acta Neuropathologica Communications, 5(76), 1-7. [More Information]
Wang, D., Mohammad, M., Wang, Y., Tan, R., Murray, L., Ricardo, S., Dagher, H., van Agtmael, T., Savige, J. (2017). The Chemical Chaperone, PBA, Reduces ER Stress and Autophagy and Increases Collagen IV α5 Expression in Cultured Fibroblasts From Men With X-Linked Alport Syndrome and Missense Mutations. Kidney International Reports, 4(3), 739-748. [More Information]
Yang, Y., Halliday, G., Hodges, J., Tan, R. (2017). Von Economo Neuron Density and Thalamus Volumes in Behavioral Deficits in Frontotemporal Dementia Cases with and without a C9ORF72 Repeat Expansion. Journal of Alzheimer's Disease, 58(3), 701-709. [More Information]
Landin-Romero, R., Tan, R., Hodges, J., Kumfor, F. (2016). An update on semantic dementia: genetics, imaging and pathology. Alzheimer's Research and Therapy, 8(1), s13195-016-0219-5. [More Information]
Tan, R., Kril, J., McGinley, C., Hassani, M., Masuda-Suzukake, M., Hasegawa, M., Mito, R., Kiernan, M., Halliday, G. (2016). Cerebellar neuronal loss in Amyotrophic Lateral Sclerosis cases with ATXN2 intermediate repeat expansions. Annals of Neurology, 79(2), 295-305. [More Information]
Bae, J., Ferguson, M., Tan, R., Mioshi, E., Simon, N., Burrell, J., Vucic, S., Hodges, J., Kiernan, M., Hornberger, M. (2016). Dissociation of structural and functional integrities of the motor system in amyotrophic lateral sclerosis and behavioral-variant frontotemporal dementia. Journal of Clinical Neurology, 12(2), 209-217. [More Information]
Guo, C., Tan, R., Hodges, J., Hu, X., Sami, S., Hornberger, M. (2016). Network-selective vulnerability of the human cerebellum to Alzheimer's disease and frontotemporal dementia. Brain, 139(5), 1527-1538. [More Information]
Halliday, G., Kiernan, M., Kril, J., Mito, R., Masuda-Suzukake, M., Hasegawa, M., McCann, H., Bartley, L., Dobson-Stone, C., Kwok, J., et al (2016). TDP-43 in the hypoglossal nucleus identifies amyotrophic lateral sclerosis in behavioral variant frontotemporal dementia. Journal of the Neurological Sciences, 366, 197-201. [More Information]
Fatima, M., Tan, R., Halliday, G., Kril, J. (2015). Spread of pathology in amyotrophic lateral sclerosis: assessment of phosphorylated TDP-43 along axonal pathways. Acta Neuropathologica Communications, 3(1), 1-9. [More Information]
Tan, R., Kril, J., Fatima, M., McGeachie, A., McCann, H., Shepherd, C., Forrest, S., Affleck, A., Kwok, J., Hodges, J., Kiernan, M., et al (2015). TDP-43 proteinopathies: pathological identification of brain regions differentiating clinical phenotypes. Brain, 138(10), 3110-3122. [More Information]
Tan, R., Devenney, E., Kiernan, M., Halliday, G., Hodges, J., Hornberger, M. (2015). Terra incognita-cerebellar contributions to neuropsychiatric and cognitive dysfunction in behavioral variant frontotemporal dementia. Frontiers in Aging Neuroscience, 7, 1-9. [More Information]
Tan, R., Wong, S., Kril, J., Piguet, O., Hornberger, M., Hodges, J., Halliday, G. (2014). Beyond the temporal pole: Limbic memory circuit in the semantic variant of primary progressive aphasia. Brain, 137(7), 2065-2076. [More Information]
Tan, R., Devenney, E., Dobson-Stone, C., Kwok, J., Hodges, J., Kiernan, M., Halliday, G., Hornberger, M. (2014). Cerebellar Integrity in the Amyotrophic Lateral Sclerosis - Frontotemporal Dementia Continuum. PloS One, 9(8), 1-10. [More Information]
Devenney, E., Homberger, M., Irish, M., Mioshi, E., Burrell, J., Tan, R., Kiernan, M., Hodges, J. (2014). Frontotemporal Dementia Associated With the C9ORF72 Mutation A Unique Clinical Profile. JAMA Neurology, 71(3), 331-339. [More Information]
Chare, L., Hodges, J., Leyton, C., McGinley, C., Tan, R., Kril, J., Halliday, G. (2014). New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications. Journal of Neurology, Neurosurgery and Psychiatry, 85(8), 866-871. [More Information]
Tan, R., Shepherd, C., Kril, J., McCann, H., McGeachie, A., McGinley, C., Affleck, A., Halliday, G. (2013). Classification of FTLD-TDP cases into pathological subtypes using antibodies against phosphorylated and non-phosphorylated TDP43. Acta Neuropathologica Communications, 1(1), 1-9. [More Information]
Tan, R., Wong, S., Hodges, J., Halliday, G., Hornberger, M. (2013). Retrosplenial Cortex (BA 29) Volumes in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders, 35(3-4), 177-182. [More Information]
Tan, R., Pok, K., Wong, S., Brooks, D., Halliday, G., Kril, J. (2013). The pathogenesis of cingulate atrophy in behavioral variant frontotemporal dementia and Alzheimer's disease. Acta Neuropathologica Communications, 1(30), 1-6. [More Information]
Hornberger, M., Wong, S., Tan, R., Irish, M., Piguet, O., Kril, J., Hodges, J., Halliday, G. (2012). In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer's disease. Brain, 135(10), 3015-3025. [More Information]

show 32 more

By Year

Expand all

2024

Timmins, H., Mok, V., Kim, S., Shahrizaila, N., Sung, J., Sobue, G., Agustini, S., Ward, S., Anstey, K., Talbot, D., Tu, S., Tan, R., Lin, C., O'Callaghan, C., Michaelian, J., Jeon, Y., Foxe, D., Naismith, S., Piguet, O., Ahmed, R., Devenney, E., Park, S., Kiernan, M., et al (2024). Regional health priorities for dementia: a roadmap for the Western Pacific. The Lancet Regional Health. Western Pacific, 50, 101179. [More Information]

2023

Mazumder, S., McCann, H., D'Silva, S., Furlong, S., Shepherd, C., Kril, J., Halliday, G., Rowe, D., Kiernan, M., Tan, R. (2023). Riluzole is associated with decreasing neuritic plaque severity in amyotrophic lateral sclerosis. Brain, 146(3), e17-e19. [More Information]
Pinkerton, M., Fernandes Lourenco Dale, G., Pacheco, M., Halliday, G., Kiernan, M., Tan, R. (2023). Survival in sporadic ALS is associated with lower p62 burden in the spinal cord. Journal of Neuropathology and Experimental Neurology, 82(9), 769-773. [More Information]
Yang, Y., Rowe, D., McCann, H., Shepherd, C., Kril, J., Kiernan, M., Halliday, G., Tan, R. (2023). Treatment with the copper compound CuATSM has no significant effect on motor neuronal pathology in patients with ALS. Neuropathology and Applied Neurobiology, 49(4). [More Information]

2021

Forrest, S., Kim, J., De Sousa, C., Cheong, R., Crockford, D., Sheedy, D., Stevens, J., McCrossin, T., Tan, R., McCann, H., Kiernan, M., Halliday, G., Kril, J., et al (2021). Coexisting Lewy body disease and clinical parkinsonism in amyotrophic lateral sclerosis. European Journal of Neurology, 28(7), 2192-2199. [More Information]

2020

Forrest, S., Halliday, G., Sizemova, A., Van Roijen, M., McGinley, C., Bright, F., Kapur, M., McGeachie, A., McCann, H., Shepherd, C., Tan, R., Kril, J., et al (2020). A Practical Approach to Differentiate the Frontotemporal Tauopathy Subtypes. Journal of Neuropathology and Experimental Neurology, 79(10), 1122-1126. [More Information]
Tan, R., Halliday, G. (2020). Author response: The underacknowledged PPA-ALS: A unique clinicopathologic subtype with strong heritability. Neurology, 94(6), 283. [More Information]

2019

Forrest, S., Crockford, D., Sizemova, A., McCann, H., Shepherd, C., McGeachie, A., Affleck, A., Carew-Jones, F., Bartley, L., Kwok, J., Kim, W., Jary, E., Tan, R., McGinley, C., Piguet, O., Hodges, J., Kril, J., Halliday, G. (2019). Coexisting Lewy body disease and clinical parkinsonism in frontotemporal lobar degeneration. Neurology, 92(21), e2472-e2482. [More Information]
Yang, Y., Halliday, G., Kiernan, M., Tan, R. (2019). TDP-43 levels in the brain tissue of ALS cases with and without C9ORF72 or ATXN2 gene expansions. Neurology, 93(19), e1748-e1755. [More Information]
Tan, R., Guennewig, B., Dobson-Stone, C., Kwok, J., Kril, J., Kiernan, M., Hodges, J., Piguet, O., Halliday, G. (2019). The underacknowledged PPA-ALS: A unique clinicopathologic subtype with strong heritability. Neurology, 92(12), e1354-e1366. [More Information]
Tan, R., Yang, Y., McCann, H., Shepherd, C., Halliday, G. (2019). Von Economo Neurons in Behavioral Variant Frontotemporal Dementia with Underlying Alzheimer's Disease. Journal of Alzheimer's Disease, 69(4), 963-967. [More Information]

show 1 more

2018

Tan, R., Yang, Y., Halliday, G. (2018). Multiple neuronal pathologies are common in young patients with pathologically proven Frontotemporal lobar degeneration. Neuropathology and Applied Neurobiology, 44(5), 522-532. [More Information]
Guo, C., Tan, R., Hodges, J., Hu, X., Sami, S., Hornberger, M. (2018). Reply: The Crus exhibits stronger functional connectivity with executive network nodes than with the default mode network. Brain, 141(4), e25. [More Information]

2017

Tan, R., Ke, Y., Ittner, L., Halliday, G. (2017). ALS/FTLD: experimental models and reality. Acta Neuropathologica, 133(2), 177-196. [More Information]
Tan, R., Kril, J., Yang, Y., Tom, N., Hodges, J., Villemagne, V., Rowe, C., Leyton, C., Kwok, J., Ittner, L., Halliday, G. (2017). Assessment of amyloid (beta) in pathologically confirmed frontotemporal dementia syndromes. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 9, 10-20. [More Information]
Gellersen, H., Guo, C., O'Callaghan, C., Tan, R., Sami, S., Hornberger, M. (2017). Cerebellar atrophy in neurodegeneration - a meta-analysis. Journal of Neurology, Neurosurgery and Psychiatry, 88(9), 780-788. [More Information]
Tan, R., Yang, Y., Kim, W., Dobson-Stone, C., Kwok, J., Kiernan, M., Halliday, G. (2017). Distinct TDP-43 inclusion morphologies in frontotemporal lobar degeneration with and without amyotrophic lateral sclerosis. Acta Neuropathologica Communications, 5(76), 1-7. [More Information]
Wang, D., Mohammad, M., Wang, Y., Tan, R., Murray, L., Ricardo, S., Dagher, H., van Agtmael, T., Savige, J. (2017). The Chemical Chaperone, PBA, Reduces ER Stress and Autophagy and Increases Collagen IV α5 Expression in Cultured Fibroblasts From Men With X-Linked Alport Syndrome and Missense Mutations. Kidney International Reports, 4(3), 739-748. [More Information]
Yang, Y., Halliday, G., Hodges, J., Tan, R. (2017). Von Economo Neuron Density and Thalamus Volumes in Behavioral Deficits in Frontotemporal Dementia Cases with and without a C9ORF72 Repeat Expansion. Journal of Alzheimer's Disease, 58(3), 701-709. [More Information]

show 3 more

2016

Landin-Romero, R., Tan, R., Hodges, J., Kumfor, F. (2016). An update on semantic dementia: genetics, imaging and pathology. Alzheimer's Research and Therapy, 8(1), s13195-016-0219-5. [More Information]
Tan, R., Kril, J., McGinley, C., Hassani, M., Masuda-Suzukake, M., Hasegawa, M., Mito, R., Kiernan, M., Halliday, G. (2016). Cerebellar neuronal loss in Amyotrophic Lateral Sclerosis cases with ATXN2 intermediate repeat expansions. Annals of Neurology, 79(2), 295-305. [More Information]
Bae, J., Ferguson, M., Tan, R., Mioshi, E., Simon, N., Burrell, J., Vucic, S., Hodges, J., Kiernan, M., Hornberger, M. (2016). Dissociation of structural and functional integrities of the motor system in amyotrophic lateral sclerosis and behavioral-variant frontotemporal dementia. Journal of Clinical Neurology, 12(2), 209-217. [More Information]
Guo, C., Tan, R., Hodges, J., Hu, X., Sami, S., Hornberger, M. (2016). Network-selective vulnerability of the human cerebellum to Alzheimer's disease and frontotemporal dementia. Brain, 139(5), 1527-1538. [More Information]
Halliday, G., Kiernan, M., Kril, J., Mito, R., Masuda-Suzukake, M., Hasegawa, M., McCann, H., Bartley, L., Dobson-Stone, C., Kwok, J., et al (2016). TDP-43 in the hypoglossal nucleus identifies amyotrophic lateral sclerosis in behavioral variant frontotemporal dementia. Journal of the Neurological Sciences, 366, 197-201. [More Information]

show 2 more

2015

Fatima, M., Tan, R., Halliday, G., Kril, J. (2015). Spread of pathology in amyotrophic lateral sclerosis: assessment of phosphorylated TDP-43 along axonal pathways. Acta Neuropathologica Communications, 3(1), 1-9. [More Information]
Tan, R., Kril, J., Fatima, M., McGeachie, A., McCann, H., Shepherd, C., Forrest, S., Affleck, A., Kwok, J., Hodges, J., Kiernan, M., et al (2015). TDP-43 proteinopathies: pathological identification of brain regions differentiating clinical phenotypes. Brain, 138(10), 3110-3122. [More Information]
Tan, R., Devenney, E., Kiernan, M., Halliday, G., Hodges, J., Hornberger, M. (2015). Terra incognita-cerebellar contributions to neuropsychiatric and cognitive dysfunction in behavioral variant frontotemporal dementia. Frontiers in Aging Neuroscience, 7, 1-9. [More Information]

2014

Tan, R., Wong, S., Kril, J., Piguet, O., Hornberger, M., Hodges, J., Halliday, G. (2014). Beyond the temporal pole: Limbic memory circuit in the semantic variant of primary progressive aphasia. Brain, 137(7), 2065-2076. [More Information]
Tan, R., Devenney, E., Dobson-Stone, C., Kwok, J., Hodges, J., Kiernan, M., Halliday, G., Hornberger, M. (2014). Cerebellar Integrity in the Amyotrophic Lateral Sclerosis - Frontotemporal Dementia Continuum. PloS One, 9(8), 1-10. [More Information]
Devenney, E., Homberger, M., Irish, M., Mioshi, E., Burrell, J., Tan, R., Kiernan, M., Hodges, J. (2014). Frontotemporal Dementia Associated With the C9ORF72 Mutation A Unique Clinical Profile. JAMA Neurology, 71(3), 331-339. [More Information]
Chare, L., Hodges, J., Leyton, C., McGinley, C., Tan, R., Kril, J., Halliday, G. (2014). New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications. Journal of Neurology, Neurosurgery and Psychiatry, 85(8), 866-871. [More Information]

show 1 more

2013

Tan, R., Shepherd, C., Kril, J., McCann, H., McGeachie, A., McGinley, C., Affleck, A., Halliday, G. (2013). Classification of FTLD-TDP cases into pathological subtypes using antibodies against phosphorylated and non-phosphorylated TDP43. Acta Neuropathologica Communications, 1(1), 1-9. [More Information]
Tan, R., Wong, S., Hodges, J., Halliday, G., Hornberger, M. (2013). Retrosplenial Cortex (BA 29) Volumes in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease. Dementia and Geriatric Cognitive Disorders, 35(3-4), 177-182. [More Information]
Tan, R., Pok, K., Wong, S., Brooks, D., Halliday, G., Kril, J. (2013). The pathogenesis of cingulate atrophy in behavioral variant frontotemporal dementia and Alzheimer's disease. Acta Neuropathologica Communications, 1(30), 1-6. [More Information]

2012

Hornberger, M., Wong, S., Tan, R., Irish, M., Piguet, O., Kril, J., Hodges, J., Halliday, G. (2012). In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer's disease. Brain, 135(10), 3015-3025. [More Information]

Selected Grants

2024

Neurotherapeutic Innovations, Tu S, Tan R, Brain and Mind Centre/BMC Strategic Program Support
Blood biomarkers of MND pathogenesis, Tan R, NSW Health/Motor Neurone Disease Research Grants

2023

Identifying and targeting distinct pathobiological subtypes to advance precision medicine in sporadic MND, Tan R, Motor Neurone Disease Research Institute of Australia/Innovator Grant
Rewarding Research 2024, Tan R, Faculty of Medicine and Health/FMH Rewarding Research Success
Neurotherapeutic Innovation, Tan R, Tu S, Brain and Mind Centre/BMC Strategic Program Support
Targeting pTDP43-mediated neurodegeneration in dementia, Tan R, Brain and Mind Centre/Margaret Ethel Jew fund for Dementia Research

2022

RNA binding proteins involved in the pathogenesis and disease heterogeneity of sporadic MND, Tan R, FightMND/Impact Grant
Reversing TDP-43 pathology and neuronal loss in sporadic MND, Tan R, FightMND/Mid-career Fellowship

2019

Prions, RNA binding proteins with prion-like domains and motor neuron degeneration, Tan R, Motor Neurone Disease Research Institute of Australia/Motor Neurone Disease Research Grants

2018

Identifying critical RNA binding proteins involved in the pathogenesis of FTD and MND, Tan R, Brain and Mind Centre/Brain and Mind Research Development Grant

2017

Is ATXN2 a potential therapeutic target in MND?, Tan R, Halliday G, Kiernan M, Motor Neurone Disease Research Institute of Australia/Grants in aid

2015

Dual and multiple proteinopathies in neurodegenerative dementias risk factors, prognostic indicators and clinical ramifications, Tan R, National Health and Medical Research Council (NHMRC)/NHMRC-ARC Dementia Research Development Fellowships

Page not found