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Associate Professor Sean Lal

BMedSci(Hons), MBBS(Hons), MPhil(Med), PhD(Med), FRACP

Clinical Academic Cardiologist
Associate Professor, Medicine and Medical Sciences

Email

sean.lal@sydney.edu.au

Details

Member of the Charles Perkins Centre

Biographical details

Sean Lal is an Associate Professor (Research and Teaching) in the School of Medical Sciences in the Faculty of Medicine and Health at the University of Sydney. He is also a Consultant Cardiologist in the Department of Cardiology at Royal Prince Alfred Hospital, where he is the Director of Acute Heart Failure Services.

Research interests

Our basic and translational research focuses on the human heart. We aim to investigate the molecular basis of cardiomyopathies, cellular changes in ageing, and intrinsic mechanisms of cardiac regeneration.

We uniquely draw on tissue from The Sydney Heart Bank (SHB), which contains over 20,000 cryopreserved human cardiac samples from our collaborations with St Vincent's Hospital (Sydney), the Australian Red Cross Donor Service and Royal Prince Alfred Hospital.

We have developed an extensive tissue database and international research network with the common goal to further our understanding of human heart failure.

Teaching and supervision

Clinically orientated anatomy

Cardiac physiology and pathology

Clinical medicine

Molecular biology

Current projects

The Sydney Heart Bank (SHB)

Overview

In 1989, in collaboration with the late Dr. Victor Chang AO, Prof. Cris dos Remedios established the Sydney Heart Bank (SHB) at the University of Sydney to collect and store explanted human hearts for research purposes. The SHB now comprises over 18,000 human cardiac samples from explanted failing hearts and non-diseased donor hearts from patients at St Vincent's Hospital Sydney. The SHB has now expanded to prospectively procure heart, aortic, and vascular samples from patients at Royal Prince Alfred Hospital under the directorship of Sean Lal, together in collaboration with Paul Bannon and Jacky Loa.

The SHB is not-for-profit and collaborates with over 30 research laboratories within Australia and around the world. The independent external research projects are in conjunction with our own in-house projects. The research projects range from examining cardiac regeneration, contractile mechanics cellular and molecular cardiology, cardiac proteomics, vascular diseases, and aortopathies.

We gratefully thank the support of the Faculty of Medicine and Health at the University of Sydney, and the Baird Institute for Heart and Lung Research in maintaining the infrastructure, staffing, and operations of the SHB. We acknowledge the patients and staff of St. Vincent's Hospital Sydney and Royal Prince Alfred Hospital.

Collaborators

Research laboratories we currently collaborate with
Australia Westmead Millennium Institute, NSW University of Melbourne University of New South Wales, NSW Victor Chang Cardiac Research Institute, NSW University of Newcastle, NSW Australian National University, ACT University of Queensland, QLD Baker IDI Heart & Diabetes Research Institute, VIC Murdoch Children’s Research Institute, VIC Monash University, VIC Federation University Australia, VIC University of Western Australia Europe Imperial College London, UK Kings College London, UK St. Georges University London VU Medical Centre, Amsterdam, The Netherlands University of Amsterdam, The Netherlands University Medical Center Utrecht, The Netherlands Ruhr University, Bochum, Germany Karolinska Institute, Sweden Uppsala University, Sweden	New Zealand University of Auckland University of Otago Asia Waseda University, Tokyo National Technological University, Singapore Canada University of Ontario United States Mayo Clinic University of Kentucky Johns Hopkins University University of Maryland Harvard Medical School Children’s Hospital Boston University of Pittsburgh University South Carolina Loyola University Chicago University of Minnesota University of Vermont

Research laboratories we currently collaborate with

Australia

Westmead Millennium Institute, NSW
University of Melbourne
University of New South Wales, NSW
Victor Chang Cardiac Research Institute, NSW
University of Newcastle, NSW
Australian National University, ACT
University of Queensland, QLD
Baker IDI Heart & Diabetes Research Institute, VIC
Murdoch Children’s Research Institute, VIC
Monash University, VIC
Federation University Australia, VIC
University of Western Australia

Europe

Imperial College London, UK
Kings College London, UK
St. Georges University London
VU Medical Centre, Amsterdam, The Netherlands
University of Amsterdam, The Netherlands
University Medical Center Utrecht, The Netherlands
Ruhr University, Bochum, Germany
Karolinska Institute, Sweden
Uppsala University, Sweden

New Zealand

University of Auckland
University of Otago

Asia

Waseda University, Tokyo
National Technological University, Singapore

Canada

University of Ontario

United States

Mayo Clinic
University of Kentucky
Johns Hopkins University
University of Maryland
Harvard Medical School
Children’s Hospital Boston
University of Pittsburgh
University South Carolina
Loyola University Chicago
University of Minnesota
University of Vermont

Executive & Scientific Review Board

Director

A/Prof Sean Lal

Biobank Manager

Dr Cassandra Malecki

Biobank RAs

Mr Lakshay Seth

RPA biobank team

Professor Paul Bannon (Cardiothoracic Surgeon)

Dr Jacky Loa (Vascular Surgeon)

A/Prof Sean Lal (Cardiologist)

Clinical nurses Lisa Turner and Lorna Beattie

Scientific Review Board

Chair: Professor Peter Macdonald

Basic Science Members

Professor Jolanda van der Velden
Professor Ken Campbell
Professor Cris dos Remedios
A/Prof Amy Li

Clinical Science Members

Dr. Jacky Loa
Professor Richmond Jeremy
Professor Paul Bannon
Professor Anne Keogh

Types of samples in the SHB

Ischaemic Cardiomyopathy
Dilated Cardiomyopathy
Hypertrophic Cardiomyopathy
Restrictive Cardiomyopathy
Alcohol induced Cardiomyopathy
Virus induced Cardiomyopathy
Peripartum Cardiomyopathy
Adriamycin induced Cardiomyopathy
Others (Marfan, Sarcoid, Myocarditis, Eisenmengers, Rheumatic, Valvular)
Thoracic aorta
Vascular (Carotid, Abdominal Aorta)
Coronary arteries
Myomectomies

Before you apply

Please provide the following documents at the time of requesting tissue:

1. Two-page project proposal. This proposal will need to satisfy the follow criteria:

2. Two-page CV/biosketch

3. Human Research Ethics Committee (HREC) approval letter from your local institution with start and end dates

Application process overview

1. Lodge a request for tissue. This must include the proposal, CV and HREC approval.

2. The documents will be assessed by members of the scientific review board.

3. If approved, the SHB will generate a Material Transfer Agreement between the two institutions.

4. The SHB will then arrange to transport at the cost of the receiving institution

Sydney Heart Bank User Policy

Any and all biological samples from the SHB must

1. Always be stored in liquid nitrogen (liquid or vapour phase)

2. Not be re-coded in any form

3. Not be used for project other than that specified in the Human Research Ethics Committee (HREC) Approval and Material Transfer Agreements.

4. Not be exchanged between institutions without pre-acknowledgement and agreement from the SHB

5. To be returned to the SHB if unused

All publication outputs (including conferences) must

1. Acknowledge and identify HREC approval from the Sydney Heart Bank and the recipient’s local institution

2. Use the original de-identified code provided by the SHB. This information enables published data to be shared between laboratories working on tissue from the same patients.

Associations

The Baird Institute

https://bairdinstitute.org.au/centre-for-heart-failure-diseases-of-the-aorta/the-sydney-heart-bank/

Themes

Obesity, Diabetes and Cardiovascular Disease

Keywords

Cardiovascular diseases, Proteomics, Regeneration medicine/Tissue engineering, Biomolecular

International links

United States

(Harvard University, MIT and The Brigham and Women's Hospital, Boston.) Mechanisms of Human Cardiac Regeneration and Heart Failure.

Current research students

Project title	Research student
Phenotypic differences between athletes and individuals with dilated cardiomyopathy	Rita-maria ABDO
Aspects of Coronary Microvascular Dysfunction and Diastolic Dysfunction	Hayden MCCOLL
Testing the failing heart's capacity to generate its own rescue fuel.	Bailey MCINTOSH

Publications

By Type

Expand all

Book Chapters

Cao, J., O'Sullivan, J., Lal, S. (2022). Pathophysiology of heart failure with reduced ejection fraction. In Andreas P. Kalogeropoulos, Hal A. Skopicki, Javed Butler (Eds.), Heart Failure - An Essential Clinical Guide, (pp. 22-31). United States: CRC Press. [More Information]
Mohamed, A., Lal, S., Ho, J., Brown, A., Lui, R., Nguyen, L., Yong, A., Su, Y., Braet, F., Dyer, W., Junius, F., Cumming, R., Freedman, B., Kritharides, L., Dos Remedios, C. (2010). How to interrogate the cellular immune system in patients with ischemic heart disease. In Dmitry Vukovic & Vladimir Kiyan (Eds.), Myocardial ischemia: Causes, symptoms and treatment, (pp. 195-216). United States: Nova Science Publishers.

Journals

Taper, M., Carrington, G., Peckham, M., Lal, S., Hume, R. (2024). A comparison of fixation and immunofluorescence protocols for successful reproducibility and improved signal in human left ventricle cardiac tissue. Journal of Microscopy. [More Information]
Dennis, M., Burrell, A., Lal, S., Ferguson, C., French, J., Bowcock, E., Kruit, N., Burns, B., Jain, P. (2024). Cardiogenic Shock Challenges and Priorities: A Clinician Survey. Heart, Lung, and Circulation. [More Information]
Wang, N., Rueter, P., Ling, M., Chandramohan, S., Hibbert, T., O'Sullivan, J., Kaye, D., Lal, S. (2024). Echocardiographic predictors of cardiovascular outcome in heart failure with preserved ejection fraction. European Journal of Heart Failure, 26(8), 1778-1787. [More Information]
Li, A., Fang, B., Li, M., Koay, Y., Malecki, C., Hunter, B., Harney, D., Dos Remedios, C., Larance, M., O'Sullivan, J., Lal, S. (2024). Myocardial Posttranscriptional Landscape in Peripartum Cardiomyopathy. Circulation. Heart Failure, 17(12), e011725. [More Information]
Wang, Z., Paterson, H., Partel, L., Wise, I., Adams, M., Cistulli, D., Ng, D., Qasabian, R., O'Sullivan, J., Lal, S., Weiss, A., Bannon, P., Hume, R. (2024). Preventing Sheep Carotid Artery Spasm for Vascular Graft Surgery and Computed Tomography Angiography. Tissue Engineering Part C: Methods, 30(8), 335-342. [More Information]
Hunter, B., Li, M., Parker, B., Koay, Y., Harney, D., Pearson, E., Cao, J., Chen, G., Guneratne, O., Smyth, G., Larance, M., O'Sullivan, J., Lal, S. (2024). Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies. Communications Biology, 7(1), 1666. [More Information]
McColl, H., Cordina, R., Lal, S., Parker, M., Hunyor, I., Medi, C., Gray, B. (2024). Recurrent immunosuppressive-responsive myocarditis in a patient with desmoplakin cardio-myopathy: a case report. European Heart Journal - Case Reports, 8(3), ytae129. [More Information]
Koay, Y., Liu, R., McIntosh, B., Vigder, N., Lauren, S., Bai, A., Tomita, S., Li, D., Harney, D., Hunter, B., Zhang, Y., Yang, J., Bannon, P., Philp, A., Larance, M., Lal, S., O'Sullivan, J., et al (2024). The Efficacy of Risk Factor Modification Compared to NAD+ Repletion in Diastolic Heart Failure. JACC: Basic to Translational Science, 9(6), 733-750. [More Information]
McNamara, J., Parker, B., Voges, H., Mehdiabadi, N., Bolk, F., Ahmad, F., Chung, J., Charitakis, N., Molendijk, J., Zech, A., Lal, S., et al (2023). Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle. Nature Cardiovascular Research, 2(2), 159-173. [More Information]
Lal, S., Campbell, K., Li, A. (2023). Editorial: Molecular and cellular mechanisms of heart failure: pathophysiology, pathogenesis and therapeutics. Frontiers in Cardovascular Medicine, 10, 1260483. [More Information]
Li, A., Shami, G., Griffiths, L., Lal, S., Irving, H., Braet, F. (2023). Giant mitochondria in cardiomyocytes: cellular architecture in health and disease. Basic Research in Cardiology, 118(1), 39. [More Information]
Wang, N., Lal, S. (2023). Importance of Tricuspid Regurgitation-Time to Move on. Circulation: Cardiovascular Imaging, 16(7), 577-579. [More Information]
Burkart, V., Kowalski, K., Disch, A., Hilfiker-Kleiner, D., Lal, S., dos Remedios, C., Perrot, A., Zeug, A., Ponimaskin, E., Kosanke, M., et al (2023). Nonsense mediated decay factor UPF3B is associated with cMyBP-C haploinsufficiency in hypertrophic cardiomyopathy patients. Journal of Molecular and Cellular Cardiology, 185, 26-37. [More Information]
Wang, N., Evans, J., Sawant, S., Sindone, J., Lal, S. (2023). Sex-specific differences in the efficacy of heart failure therapies: a meta-analysis of 84,818 patients. Heart Failure Reviews, 28(4), 949-959. [More Information]
Sharma, V., Green, A., McLean, A., Adegoke, J., Gordon, C., Starkey, G., D'Costa, R., James, F., Afara, I., Lal, S., et al (2023). Towards a point-of-care multimodal spectroscopy instrument for the evaluation of human cardiac tissue. Heart and Vessels: an international journal, 38(12), 1476-1485. [More Information]
Taylor, J., Yeung, A., Ashton, A., Faiz, A., Guryev, V., Fang, B., Lal, S., Grosser, M., Dos Remedios, C., Braet, F., Li, A., et al (2023). Transcriptomic Comparison of Human Peripartum and Dilated Cardiomyopathy Identifies Differences in Key Disease Pathways. Journal of Cardiovascular Development and Disease, 10(5). [More Information]
Zhu, Y., Jackson, D., Hunter, B., Beattie, L., Turner, L., Hambly, B., Jeremy, R., Malecki, C., Robertson, E., Li, A., Dos Remedios, C., Richmond, D., Semsarian, C., O'Sullivan, J., Bannon, P., Lal, S. (2022). Models of cardiovascular surgery biobanking to facilitate translational research and precision medicine. ESC Heart Failure, 9(1), 21-30. [More Information]
Ezeani, M., Hagemeyer, C., Lal, S., Niego, B. (2022). Molecular imaging of atrial myopathy: Towards early AF detection and non-invasive disease management. Trends In Cardiovascular Medicine, 32(1), 20-31. [More Information]
Dennis, M., Howpage, S., McGill, M., Dutta, S., Koay, Y., Nguyen-Lal, L., Lal, S., Wu, T., Ugander, M., Wang, A., Wong, J., Constantino, M., O'Sullivan, J., Twigg, S., Puranik, R., et al (2022). Myocardial fibrosis in Type 2 Diabetes is associated with functional and metabolomic parameters. International Journal of Cardiology, 363, 179-184. [More Information]
Li, A., Campbell, K., Lal, S., Ge, Y., Keogh, A., Macdonald, P., Lau, P., Lai, J., Linke, W., Van der Velden, J., Dos Remedios, C., et al (2022). Peripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease. Biophysical Reviews, 14(1), 369-379. [More Information]
Morris, P., Lal, S., Bao, B., Dennis, M., Hunyor, I., O'Sullivan, J., Grieve, S., Puranik, R. (2022). Relationship of Myocardial Gadolinium Enhancement to Late Clinical Outcomes: Implications for the COVID-19 era. Heart, Lung, and Circulation, 31(3), e29-e30. [More Information]
Vikhorev, P., Vikhoreva, N., Yeung, W., Li, A., Lal, S., dos Remedios, C., Blair, C., Guglin, M., Campbell, K., Yacoub, M., et al (2022). Titin-truncating mutations associated with dilated cardiomyopathy alter length-dependent activation and its modulation via phosphorylation. Cardiovascular Research, 118(1), 241-253. [More Information]
Ezeani, M., Noor, A., Alt, K., Lal, S., Donnelly, P., Hagemeyer, C., Niego, B. (2021). Collagen-targeted peptides for molecular imaging of diffuse cardiac fibrosis. Journal of the American Heart Association, 10(18), e022139. [More Information]
Chiang, S., Braidy, N., Maleki, S., Lal, S., Richardson, D., Huang, M. (2021). Mechanisms of impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation. Redox Biology, 46, 102038. [More Information]
Dutta, S., Li, D., Wang, A., Ishak, M., Cook, K., Farnham, M., Dissanayake, H., Cistulli, P., Hunyor, I., Liu, R., Wilcox, I., Koay, Y., Yang, J., Lal, S., O'Sullivan, J. (2021). Metabolite signatures of heart failure, sleep apnoea, their interaction, and outcomes in the community. ESC Heart Failure, 8(6), 5392-5402. [More Information]
Hou, Y., Bai, J., Shen, X., de Langen, O., Li, A., Lal, S., dos Remedios, C., Baddeley, D., Ruygrok, P., Soeller, C., et al (2021). Nanoscale Organisation of Ryanodine Receptors and Junctophilin-2 in the Failing Human Heart. Frontiers in Physiology, 12, 724372. [More Information]
Fusco-Allison, G., Li, D., Hunter, B., Jackson, D., Bannon, P., Lal, S., O'Sullivan, J. (2021). Optimizing the discovery and assessment of therapeutic targets in heart failure with preserved ejection fraction. ESC Heart Failure, 8(5), 3643-3655. [More Information]
Sim, C., Phipson, B., Ziemann, M., Rafehi, H., Mills, R., Watt, K., Abu-Bonsrah, K., Kalathur, R., Voges, H., Dinh, D., Dos Remedios, C., Lal, S., et al (2021). Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor. Circulation, 143(16), 1614-1628. [More Information]
Holliday, M., Singer, E., Ross, S., Lim, S., Lal, S., Ingles, J., Semsarian, C., Bagnall, R. (2021). Transcriptome Sequencing of Patients with Hypertrophic Cardiomyopathy Reveals Novel Splice-altering Variants in MYBPC3. Circulation. Genomic and Precision Medicine, 14(2), e003202. [More Information]
Yester, J., Liu, H., Gyngard, F., Ammanamanchi, N., Little, K., Thomas, D., Sullivan, M., Lal, S., Steinhauser, M., Kühn, B. (2021). Use of stable isotope-tagged thymidine and multi-isotope imaging mass spectrometry (MIMS) for quantification of human cardiomyocyte division. Nature Protocols, 16(4), 1995-2022. [More Information]
Wang, N., Wilcox, I., Lal, S. (2020). Cholesterol lowering: to live longer, start younger? Aging, 12(4), 3119-3120. [More Information]
Li, M., Parker, B., Pearson, E., Hunter, B., Cao, J., Koay, Y., Guneratne, O., James, D., Yang, J., Lal, S., O'Sullivan, J. (2020). Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy. Nature Communications, 11(1), 2843. [More Information]
Lal, S., Hayward, C., De Pasquale, C., Kaye, D., Javorsky, G., Bergin, P., Atherton, J., Ilton, M., Weintraub, R., Nair, P., Rudas, M., Bannon, P., Chow, C., Lattimore, J., Kritharides, L., Totaro, R., et al (2020). COVID-19 and Acute Heart Failure: Screening the Critically Ill – A Position Statement of the Cardiac Society of Australia and New Zealand (CSANZ). Heart, Lung, and Circulation, 29(7), e94-e98. [More Information]
Wang, N., Cao, J., Lal, S. (2020). COVID-19: getting to the heart of the matter. European Journal of Heart Failure, 22(12), 69. [More Information]
Tucholski, T., Cai, W., Gregorich, Z., Bayne, E., Mitchell, S., McIlwain, S., de Lange, W., Wrobbel, M., Karp, H., Hite, Z., Lal, S., Li, A., Dos Remedios, C., et al (2020). Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics. Proceedings of the National Academy of Sciences of the United States of America, 117(40), 24691-24700. [More Information]
Dennis, M., Lal, S., Forrest, P., Nichol, A., Lamhaut, L., Totaro, R., Burns, B., Sandroni, C. (2020). In-Depth Extracorporeal Cardiopulmonary Resuscitation in Adult Out-of-Hospital Cardiac Arrest. Journal of the American Heart Association, 9(10), e016521. [More Information]
Wang, N., Fulcher, J., Abeysuriya, N., Park, L., Kumar, S., Di Tanna, G., Wilcox, I., Keech, A., Rodgers, A., Lal, S. (2020). Intensive LDL cholesterol-lowering treatment beyond current recommendations for the prevention of major vascular events: a systematic review and meta-analysis of randomised trials including 327037 participants. The Lancet Diabetes & Endocrinology, 8(1), 36-49. [More Information]
Moonen, A., Lal, S., Ingles, J., Yeates, L., Semsarian, C., Puranik, R. (2020). Prevalence of Anderson-Fabry disease in a cohort with unexplained late gadolinium enhancement on cardiac MRI. International Journal of Cardiology, 304, 122-124. [More Information]
Li, A., Lal, S., Dos Remedios, C. (2019). A step towards understanding the molecular nature of human heart failure: advances using the Sydney Heart Bank collection. Biophysical Reviews, 11(2), 241-244. [More Information]
Liu, C., Lim, S., Teo, M., Tan, M., Kulkarni, M., Qiu, B., Li, A., Lal, S., Dos Remedios, C., Tan, N., et al (2019). Collaborative Regulation of LRG1 by TGF-Beta1 and PPAR-Beta/Delta Modulates Chronic Pressure Overload-Induced Cardiac Fibrosis. Circulation. Heart Failure, 12(12), 1-16. [More Information]
Cao, J., Koay, Y., Quek, L., Parker, B., Lal, S., O'Sullivan, J. (2019). Myocardial substrate changes in advanced ischaemic and advanced dilated human heart failure. European Journal of Heart Failure, 21(8), 1042-1045. [More Information]
Ge, Z., Li, A., McNamara, J., Dos Remedios, C., Lal, S. (2019). Pathogenesis and pathophysiology of heart failure with reduced ejection fraction: translation to human studies. Heart Failure Reviews, 24(5), 743-758. [More Information]
Lal, S., Kuhn, B. (2019). Regenerating Hearts by Arresting Development With Hypothyroidism. Circulation Research, 124(12), 1725-1726. [More Information]
Wang, N., Fulcher, J., Abeysuriya, N., McGrady, M., Wilcox, I., Celermajer, D., Lal, S. (2019). Tricuspid regurgitation is associated with increased mortality independent of pulmonary pressures and right heart failure: a systematic review and meta-analysis. European Heart Journal, 40(5), 476-484. [More Information]
Dos Remedios, C., Lal, S., Li, A., McNamara, J., Keogh, A., MacDonald, P., Cooke, R., Ehler, E., Knoll, R., Marston, S., et al (2018). Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. Biophysical Reviews, 10(3), 941. [More Information]
Lal, S., Kotchetkova, I., Cao, J., Jackson, D., Cordina, R., Celermajer, D. (2018). Heart failure admissions and poor subsequent outcomes in adults with congenital heart disease. European Journal of Heart Failure, 20(4), 812-815. [More Information]
Dos Remedios, C., Li, A., Lal, S. (2018). Non-sarcomeric causes of heart failure: a Sydney Heart Bank perspective. Biophysical Reviews, 10(4), 949-954. [More Information]
Wang, N., Fulcher, J., Abeysuriya, N., Adams, M., Lal, S. (2018). Predictors of successful chronic total occlusion percutaneous coronary interventions: a systematic review and meta-analysis. Heart, 104(6), 517-524. [More Information]
Lal, S. (2018). Primary Sjogren's Syndrome. New England Journal of Medicine, 379(1), 96-97. [More Information]
Cao, J., Lee, S., Phan, K., Celermajer, D., Lal, S. (2018). Renin-angiotensin-aldosterone inhibition improves right ventricular function: a meta-analysis. Heart Asia, 10(1), 1-7. [More Information]
Bagnall, R., Ingles, J., Dinger, M., Cowley, M., Ross, S., Minoche, A., Lal, S., Turner, C., Colley, A., Rajagopalan, S., Semsarian, C., et al (2018). Whole Genome Sequencing Improves Outcomes of Genetic Testing in Patients With Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology, 72(4), 419-429. [More Information]
Vikhorev, P., Smoktunowicz, N., Munster, A., Copeland, O., Kostin, S., Montgiraud, C., Messer, A., Toliat, M., Li, A., Dos Remedios, C., Lal, S., et al (2017). Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes. Scientific Reports, 7(1), 1-11. [More Information]
Mamidi, R., Li, J., Gresham, K., Verma, S., Doh, C., Li, A., Lal, S., Dos Remedios, C., Stelzer, J. (2017). Dose-Dependent Effects of the Myosin Activator Omecamtiv Mecarbil on Cross-Bridge Behavior and Force Generation in Failing Human Myocardium. Circulation. Heart Failure, 10(10), 1-11. [More Information]
Crossman, D., Shen, X., Jullig, M., Munro, M., Hou, Y., Middleditch, M., Shrestha, D., Li, A., Lal, S., Dos Remedios, C., et al (2017). Increased collagen within the transverse tubules in human heart failure. Cardiovascular Research, 113(8), 879-891. [More Information]
McNamara, J., Li, A., Lal, S., Bos, J., Harris, S., van der Velden, J., Ackerman, M., Cooke, R., Dos Remedios, C. (2017). MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy. PloS One, 12(6), 1-22. [More Information]
Wang, N., Lal, S. (2017). Post-dilation in transcatheter aortic valve replacement: A systematic review and meta-analysis. Journal of Interventional Cardiology, 30(3), 204-211. [More Information]
Dos Remedios, C., Lal, S., Li, A., McNamara, J., Keogh, A., Macdonald, P., Cooke, R., Ehler, E., Knoll, R., Marston, S., et al (2017). The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. Biophysical Reviews, 9(4), 431-441. [More Information]
McNamara, J., Li, A., Smith, N., Lal, S., Graham, R., Kooiker, K., van Dijk, S., Dos Remedios, C., Harris, S., Cooke, R. (2016). Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. Journal of Molecular and Cellular Cardiology, 94, 65-71. [More Information]
Lal, S., Turner, L., Powell, C., Wilson, M., Bannon, P. (2016). Improvements in left ventricular ejection fraction and quality of life in patients with heart failure who undergo coronary artery bypass surgery. International Journal of Cardiology, 222, 671-673. [More Information]
Lal, S., Li, A., Dos Remedios, C. (2016). Limitations in Translating Animal Studies to Humans in Cardiovascular Disease. Journal of Cardiovascular Translational Research, 9(2), 165-166. [More Information]
Lal, S., Nguyen, L., Tezone, R., Ponten, F., Odeberg, J., Li, A., Dos Remedios, C. (2016). Tissue microarray profiling in human heart failure. Proteomics, 16(17), 2319-2326. [More Information]
Lal, S., Li, A., Allen, D., Allen, P., Bannon, P., Cartmill, T., Cooke, R., Farnswoirth, A., Keogh, A., Dos Remedios, C. (2015). Best practice BioBanking of human heart tissue. Biophysical Reviews, 7(4), 399-406. [More Information]
Ge, Z., Lal, S., Le, T., Dos Remedios, C., Chong, J. (2015). Cardiac stem cells: translation to human studies. Biophysical Reviews, 7(1), 127-139. [More Information]
Koopmann, T., Adriaens, M., Moerland, P., Marsman, R., Westerveld, M., Lal, S., Zhang, T., Simmons, C., Baczko, I., Dos Remedios, C., et al (2014). Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart. PloS One, 9(5), 1-11. [More Information]
Li, A., Estigoy, C., Raftery, M., Cameron, D., Odeberg, J., Ponten, F., Lal, S., Dos Remedios, C. (2013). Heart Research Advances Using Database Search Engines, Human Protein Atlas and the Sydney Heart Bank. Heart, Lung, and Circulation, 22(10), 819-826. [More Information]
Cahill, H., Jones, A., Herkes, R., Cook, K., Stirling, A., Halbert, T., Yates, A., Lal, S., Gardo, A., Donnelly, R., Gattas, D. (2011). Introduction of a new observation chart and education programme is associated with higher rates of vital-sign ascertainment in hospital wards. BMJ Quality and Safety, 20(9), 791-796. [More Information]
Wolfe, J., Ishiwata, S., Braet, F., Whan, R., Su, Y., Lal, S., Dos Remedios, C. (2011). SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation. Biophysical Reviews, 3(2), 53-62. [More Information]
Lal, S., Dos Remedios, C. (2010). Is There a Connection between Ablation of Atrial Fibrillation and Reduced Apoptosis? Cardiology, 117(3), 161-2. [More Information]
Lal, S., Brown, A., Nguyen, L., Braet, F., Dyer, W., Dos Remedios, C. (2009). Using antibody arrays to detect microparticles from acute coronary syndrome patients based on Cluster of Differentiation (CD) antigen expression. Molecular and Cellular Proteomics, 8(4), 799-804. [More Information]
Lal, S., Lui, R., Nguyen, L., Macdonald, P., Denyer, G., Dos Remedios, C. (2004). Increases In Leukocyte Cluster Of Differentiation Antigen Expression During Cardiopulmonary Bypass In Patients Undergoing Heart Transplantation. Proteomics, 4(7), 1918-1926. [More Information]
Lal, S., Christopherson, R., Dos Remedios, C. (2002). Antibody arrays: an embryonic but rapidly growing technology. Drug Discovery Today, 7(18 Supplement), S143-S149. [More Information]

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By Year

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2024

Taper, M., Carrington, G., Peckham, M., Lal, S., Hume, R. (2024). A comparison of fixation and immunofluorescence protocols for successful reproducibility and improved signal in human left ventricle cardiac tissue. Journal of Microscopy. [More Information]
Dennis, M., Burrell, A., Lal, S., Ferguson, C., French, J., Bowcock, E., Kruit, N., Burns, B., Jain, P. (2024). Cardiogenic Shock Challenges and Priorities: A Clinician Survey. Heart, Lung, and Circulation. [More Information]
Wang, N., Rueter, P., Ling, M., Chandramohan, S., Hibbert, T., O'Sullivan, J., Kaye, D., Lal, S. (2024). Echocardiographic predictors of cardiovascular outcome in heart failure with preserved ejection fraction. European Journal of Heart Failure, 26(8), 1778-1787. [More Information]
Li, A., Fang, B., Li, M., Koay, Y., Malecki, C., Hunter, B., Harney, D., Dos Remedios, C., Larance, M., O'Sullivan, J., Lal, S. (2024). Myocardial Posttranscriptional Landscape in Peripartum Cardiomyopathy. Circulation. Heart Failure, 17(12), e011725. [More Information]
Wang, Z., Paterson, H., Partel, L., Wise, I., Adams, M., Cistulli, D., Ng, D., Qasabian, R., O'Sullivan, J., Lal, S., Weiss, A., Bannon, P., Hume, R. (2024). Preventing Sheep Carotid Artery Spasm for Vascular Graft Surgery and Computed Tomography Angiography. Tissue Engineering Part C: Methods, 30(8), 335-342. [More Information]
Hunter, B., Li, M., Parker, B., Koay, Y., Harney, D., Pearson, E., Cao, J., Chen, G., Guneratne, O., Smyth, G., Larance, M., O'Sullivan, J., Lal, S. (2024). Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies. Communications Biology, 7(1), 1666. [More Information]
McColl, H., Cordina, R., Lal, S., Parker, M., Hunyor, I., Medi, C., Gray, B. (2024). Recurrent immunosuppressive-responsive myocarditis in a patient with desmoplakin cardio-myopathy: a case report. European Heart Journal - Case Reports, 8(3), ytae129. [More Information]
Koay, Y., Liu, R., McIntosh, B., Vigder, N., Lauren, S., Bai, A., Tomita, S., Li, D., Harney, D., Hunter, B., Zhang, Y., Yang, J., Bannon, P., Philp, A., Larance, M., Lal, S., O'Sullivan, J., et al (2024). The Efficacy of Risk Factor Modification Compared to NAD+ Repletion in Diastolic Heart Failure. JACC: Basic to Translational Science, 9(6), 733-750. [More Information]

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2023

McNamara, J., Parker, B., Voges, H., Mehdiabadi, N., Bolk, F., Ahmad, F., Chung, J., Charitakis, N., Molendijk, J., Zech, A., Lal, S., et al (2023). Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle. Nature Cardiovascular Research, 2(2), 159-173. [More Information]
Lal, S., Campbell, K., Li, A. (2023). Editorial: Molecular and cellular mechanisms of heart failure: pathophysiology, pathogenesis and therapeutics. Frontiers in Cardovascular Medicine, 10, 1260483. [More Information]
Li, A., Shami, G., Griffiths, L., Lal, S., Irving, H., Braet, F. (2023). Giant mitochondria in cardiomyocytes: cellular architecture in health and disease. Basic Research in Cardiology, 118(1), 39. [More Information]
Wang, N., Lal, S. (2023). Importance of Tricuspid Regurgitation-Time to Move on. Circulation: Cardiovascular Imaging, 16(7), 577-579. [More Information]
Burkart, V., Kowalski, K., Disch, A., Hilfiker-Kleiner, D., Lal, S., dos Remedios, C., Perrot, A., Zeug, A., Ponimaskin, E., Kosanke, M., et al (2023). Nonsense mediated decay factor UPF3B is associated with cMyBP-C haploinsufficiency in hypertrophic cardiomyopathy patients. Journal of Molecular and Cellular Cardiology, 185, 26-37. [More Information]
Wang, N., Evans, J., Sawant, S., Sindone, J., Lal, S. (2023). Sex-specific differences in the efficacy of heart failure therapies: a meta-analysis of 84,818 patients. Heart Failure Reviews, 28(4), 949-959. [More Information]
Sharma, V., Green, A., McLean, A., Adegoke, J., Gordon, C., Starkey, G., D'Costa, R., James, F., Afara, I., Lal, S., et al (2023). Towards a point-of-care multimodal spectroscopy instrument for the evaluation of human cardiac tissue. Heart and Vessels: an international journal, 38(12), 1476-1485. [More Information]
Taylor, J., Yeung, A., Ashton, A., Faiz, A., Guryev, V., Fang, B., Lal, S., Grosser, M., Dos Remedios, C., Braet, F., Li, A., et al (2023). Transcriptomic Comparison of Human Peripartum and Dilated Cardiomyopathy Identifies Differences in Key Disease Pathways. Journal of Cardiovascular Development and Disease, 10(5). [More Information]

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2022

Zhu, Y., Jackson, D., Hunter, B., Beattie, L., Turner, L., Hambly, B., Jeremy, R., Malecki, C., Robertson, E., Li, A., Dos Remedios, C., Richmond, D., Semsarian, C., O'Sullivan, J., Bannon, P., Lal, S. (2022). Models of cardiovascular surgery biobanking to facilitate translational research and precision medicine. ESC Heart Failure, 9(1), 21-30. [More Information]
Ezeani, M., Hagemeyer, C., Lal, S., Niego, B. (2022). Molecular imaging of atrial myopathy: Towards early AF detection and non-invasive disease management. Trends In Cardiovascular Medicine, 32(1), 20-31. [More Information]
Dennis, M., Howpage, S., McGill, M., Dutta, S., Koay, Y., Nguyen-Lal, L., Lal, S., Wu, T., Ugander, M., Wang, A., Wong, J., Constantino, M., O'Sullivan, J., Twigg, S., Puranik, R., et al (2022). Myocardial fibrosis in Type 2 Diabetes is associated with functional and metabolomic parameters. International Journal of Cardiology, 363, 179-184. [More Information]
Cao, J., O'Sullivan, J., Lal, S. (2022). Pathophysiology of heart failure with reduced ejection fraction. In Andreas P. Kalogeropoulos, Hal A. Skopicki, Javed Butler (Eds.), Heart Failure - An Essential Clinical Guide, (pp. 22-31). United States: CRC Press. [More Information]
Li, A., Campbell, K., Lal, S., Ge, Y., Keogh, A., Macdonald, P., Lau, P., Lai, J., Linke, W., Van der Velden, J., Dos Remedios, C., et al (2022). Peripartum cardiomyopathy: a global effort to find the cause and cure for the rare and little understood disease. Biophysical Reviews, 14(1), 369-379. [More Information]
Morris, P., Lal, S., Bao, B., Dennis, M., Hunyor, I., O'Sullivan, J., Grieve, S., Puranik, R. (2022). Relationship of Myocardial Gadolinium Enhancement to Late Clinical Outcomes: Implications for the COVID-19 era. Heart, Lung, and Circulation, 31(3), e29-e30. [More Information]
Vikhorev, P., Vikhoreva, N., Yeung, W., Li, A., Lal, S., dos Remedios, C., Blair, C., Guglin, M., Campbell, K., Yacoub, M., et al (2022). Titin-truncating mutations associated with dilated cardiomyopathy alter length-dependent activation and its modulation via phosphorylation. Cardiovascular Research, 118(1), 241-253. [More Information]

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2021

Ezeani, M., Noor, A., Alt, K., Lal, S., Donnelly, P., Hagemeyer, C., Niego, B. (2021). Collagen-targeted peptides for molecular imaging of diffuse cardiac fibrosis. Journal of the American Heart Association, 10(18), e022139. [More Information]
Chiang, S., Braidy, N., Maleki, S., Lal, S., Richardson, D., Huang, M. (2021). Mechanisms of impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation. Redox Biology, 46, 102038. [More Information]
Dutta, S., Li, D., Wang, A., Ishak, M., Cook, K., Farnham, M., Dissanayake, H., Cistulli, P., Hunyor, I., Liu, R., Wilcox, I., Koay, Y., Yang, J., Lal, S., O'Sullivan, J. (2021). Metabolite signatures of heart failure, sleep apnoea, their interaction, and outcomes in the community. ESC Heart Failure, 8(6), 5392-5402. [More Information]
Hou, Y., Bai, J., Shen, X., de Langen, O., Li, A., Lal, S., dos Remedios, C., Baddeley, D., Ruygrok, P., Soeller, C., et al (2021). Nanoscale Organisation of Ryanodine Receptors and Junctophilin-2 in the Failing Human Heart. Frontiers in Physiology, 12, 724372. [More Information]
Fusco-Allison, G., Li, D., Hunter, B., Jackson, D., Bannon, P., Lal, S., O'Sullivan, J. (2021). Optimizing the discovery and assessment of therapeutic targets in heart failure with preserved ejection fraction. ESC Heart Failure, 8(5), 3643-3655. [More Information]
Sim, C., Phipson, B., Ziemann, M., Rafehi, H., Mills, R., Watt, K., Abu-Bonsrah, K., Kalathur, R., Voges, H., Dinh, D., Dos Remedios, C., Lal, S., et al (2021). Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor. Circulation, 143(16), 1614-1628. [More Information]
Holliday, M., Singer, E., Ross, S., Lim, S., Lal, S., Ingles, J., Semsarian, C., Bagnall, R. (2021). Transcriptome Sequencing of Patients with Hypertrophic Cardiomyopathy Reveals Novel Splice-altering Variants in MYBPC3. Circulation. Genomic and Precision Medicine, 14(2), e003202. [More Information]
Yester, J., Liu, H., Gyngard, F., Ammanamanchi, N., Little, K., Thomas, D., Sullivan, M., Lal, S., Steinhauser, M., Kühn, B. (2021). Use of stable isotope-tagged thymidine and multi-isotope imaging mass spectrometry (MIMS) for quantification of human cardiomyocyte division. Nature Protocols, 16(4), 1995-2022. [More Information]

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2020

Wang, N., Wilcox, I., Lal, S. (2020). Cholesterol lowering: to live longer, start younger? Aging, 12(4), 3119-3120. [More Information]
Li, M., Parker, B., Pearson, E., Hunter, B., Cao, J., Koay, Y., Guneratne, O., James, D., Yang, J., Lal, S., O'Sullivan, J. (2020). Core functional nodes and sex-specific pathways in human ischaemic and dilated cardiomyopathy. Nature Communications, 11(1), 2843. [More Information]
Lal, S., Hayward, C., De Pasquale, C., Kaye, D., Javorsky, G., Bergin, P., Atherton, J., Ilton, M., Weintraub, R., Nair, P., Rudas, M., Bannon, P., Chow, C., Lattimore, J., Kritharides, L., Totaro, R., et al (2020). COVID-19 and Acute Heart Failure: Screening the Critically Ill – A Position Statement of the Cardiac Society of Australia and New Zealand (CSANZ). Heart, Lung, and Circulation, 29(7), e94-e98. [More Information]
Wang, N., Cao, J., Lal, S. (2020). COVID-19: getting to the heart of the matter. European Journal of Heart Failure, 22(12), 69. [More Information]
Tucholski, T., Cai, W., Gregorich, Z., Bayne, E., Mitchell, S., McIlwain, S., de Lange, W., Wrobbel, M., Karp, H., Hite, Z., Lal, S., Li, A., Dos Remedios, C., et al (2020). Distinct hypertrophic cardiomyopathy genotypes result in convergent sarcomeric proteoform profiles revealed by top-down proteomics. Proceedings of the National Academy of Sciences of the United States of America, 117(40), 24691-24700. [More Information]
Dennis, M., Lal, S., Forrest, P., Nichol, A., Lamhaut, L., Totaro, R., Burns, B., Sandroni, C. (2020). In-Depth Extracorporeal Cardiopulmonary Resuscitation in Adult Out-of-Hospital Cardiac Arrest. Journal of the American Heart Association, 9(10), e016521. [More Information]
Wang, N., Fulcher, J., Abeysuriya, N., Park, L., Kumar, S., Di Tanna, G., Wilcox, I., Keech, A., Rodgers, A., Lal, S. (2020). Intensive LDL cholesterol-lowering treatment beyond current recommendations for the prevention of major vascular events: a systematic review and meta-analysis of randomised trials including 327037 participants. The Lancet Diabetes & Endocrinology, 8(1), 36-49. [More Information]
Moonen, A., Lal, S., Ingles, J., Yeates, L., Semsarian, C., Puranik, R. (2020). Prevalence of Anderson-Fabry disease in a cohort with unexplained late gadolinium enhancement on cardiac MRI. International Journal of Cardiology, 304, 122-124. [More Information]

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2019

Li, A., Lal, S., Dos Remedios, C. (2019). A step towards understanding the molecular nature of human heart failure: advances using the Sydney Heart Bank collection. Biophysical Reviews, 11(2), 241-244. [More Information]
Liu, C., Lim, S., Teo, M., Tan, M., Kulkarni, M., Qiu, B., Li, A., Lal, S., Dos Remedios, C., Tan, N., et al (2019). Collaborative Regulation of LRG1 by TGF-Beta1 and PPAR-Beta/Delta Modulates Chronic Pressure Overload-Induced Cardiac Fibrosis. Circulation. Heart Failure, 12(12), 1-16. [More Information]
Cao, J., Koay, Y., Quek, L., Parker, B., Lal, S., O'Sullivan, J. (2019). Myocardial substrate changes in advanced ischaemic and advanced dilated human heart failure. European Journal of Heart Failure, 21(8), 1042-1045. [More Information]
Ge, Z., Li, A., McNamara, J., Dos Remedios, C., Lal, S. (2019). Pathogenesis and pathophysiology of heart failure with reduced ejection fraction: translation to human studies. Heart Failure Reviews, 24(5), 743-758. [More Information]
Lal, S., Kuhn, B. (2019). Regenerating Hearts by Arresting Development With Hypothyroidism. Circulation Research, 124(12), 1725-1726. [More Information]
Wang, N., Fulcher, J., Abeysuriya, N., McGrady, M., Wilcox, I., Celermajer, D., Lal, S. (2019). Tricuspid regurgitation is associated with increased mortality independent of pulmonary pressures and right heart failure: a systematic review and meta-analysis. European Heart Journal, 40(5), 476-484. [More Information]

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2018

Dos Remedios, C., Lal, S., Li, A., McNamara, J., Keogh, A., MacDonald, P., Cooke, R., Ehler, E., Knoll, R., Marston, S., et al (2018). Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. Biophysical Reviews, 10(3), 941. [More Information]
Lal, S., Kotchetkova, I., Cao, J., Jackson, D., Cordina, R., Celermajer, D. (2018). Heart failure admissions and poor subsequent outcomes in adults with congenital heart disease. European Journal of Heart Failure, 20(4), 812-815. [More Information]
Dos Remedios, C., Li, A., Lal, S. (2018). Non-sarcomeric causes of heart failure: a Sydney Heart Bank perspective. Biophysical Reviews, 10(4), 949-954. [More Information]
Wang, N., Fulcher, J., Abeysuriya, N., Adams, M., Lal, S. (2018). Predictors of successful chronic total occlusion percutaneous coronary interventions: a systematic review and meta-analysis. Heart, 104(6), 517-524. [More Information]
Lal, S. (2018). Primary Sjogren's Syndrome. New England Journal of Medicine, 379(1), 96-97. [More Information]
Cao, J., Lee, S., Phan, K., Celermajer, D., Lal, S. (2018). Renin-angiotensin-aldosterone inhibition improves right ventricular function: a meta-analysis. Heart Asia, 10(1), 1-7. [More Information]
Bagnall, R., Ingles, J., Dinger, M., Cowley, M., Ross, S., Minoche, A., Lal, S., Turner, C., Colley, A., Rajagopalan, S., Semsarian, C., et al (2018). Whole Genome Sequencing Improves Outcomes of Genetic Testing in Patients With Hypertrophic Cardiomyopathy. Journal of the American College of Cardiology, 72(4), 419-429. [More Information]

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2017

Vikhorev, P., Smoktunowicz, N., Munster, A., Copeland, O., Kostin, S., Montgiraud, C., Messer, A., Toliat, M., Li, A., Dos Remedios, C., Lal, S., et al (2017). Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes. Scientific Reports, 7(1), 1-11. [More Information]
Mamidi, R., Li, J., Gresham, K., Verma, S., Doh, C., Li, A., Lal, S., Dos Remedios, C., Stelzer, J. (2017). Dose-Dependent Effects of the Myosin Activator Omecamtiv Mecarbil on Cross-Bridge Behavior and Force Generation in Failing Human Myocardium. Circulation. Heart Failure, 10(10), 1-11. [More Information]
Crossman, D., Shen, X., Jullig, M., Munro, M., Hou, Y., Middleditch, M., Shrestha, D., Li, A., Lal, S., Dos Remedios, C., et al (2017). Increased collagen within the transverse tubules in human heart failure. Cardiovascular Research, 113(8), 879-891. [More Information]
McNamara, J., Li, A., Lal, S., Bos, J., Harris, S., van der Velden, J., Ackerman, M., Cooke, R., Dos Remedios, C. (2017). MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy. PloS One, 12(6), 1-22. [More Information]
Wang, N., Lal, S. (2017). Post-dilation in transcatheter aortic valve replacement: A systematic review and meta-analysis. Journal of Interventional Cardiology, 30(3), 204-211. [More Information]
Dos Remedios, C., Lal, S., Li, A., McNamara, J., Keogh, A., Macdonald, P., Cooke, R., Ehler, E., Knoll, R., Marston, S., et al (2017). The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease. Biophysical Reviews, 9(4), 431-441. [More Information]

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2016

McNamara, J., Li, A., Smith, N., Lal, S., Graham, R., Kooiker, K., van Dijk, S., Dos Remedios, C., Harris, S., Cooke, R. (2016). Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes. Journal of Molecular and Cellular Cardiology, 94, 65-71. [More Information]
Lal, S., Turner, L., Powell, C., Wilson, M., Bannon, P. (2016). Improvements in left ventricular ejection fraction and quality of life in patients with heart failure who undergo coronary artery bypass surgery. International Journal of Cardiology, 222, 671-673. [More Information]
Lal, S., Li, A., Dos Remedios, C. (2016). Limitations in Translating Animal Studies to Humans in Cardiovascular Disease. Journal of Cardiovascular Translational Research, 9(2), 165-166. [More Information]
Lal, S., Nguyen, L., Tezone, R., Ponten, F., Odeberg, J., Li, A., Dos Remedios, C. (2016). Tissue microarray profiling in human heart failure. Proteomics, 16(17), 2319-2326. [More Information]

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2015

Lal, S., Li, A., Allen, D., Allen, P., Bannon, P., Cartmill, T., Cooke, R., Farnswoirth, A., Keogh, A., Dos Remedios, C. (2015). Best practice BioBanking of human heart tissue. Biophysical Reviews, 7(4), 399-406. [More Information]
Ge, Z., Lal, S., Le, T., Dos Remedios, C., Chong, J. (2015). Cardiac stem cells: translation to human studies. Biophysical Reviews, 7(1), 127-139. [More Information]

2014

Koopmann, T., Adriaens, M., Moerland, P., Marsman, R., Westerveld, M., Lal, S., Zhang, T., Simmons, C., Baczko, I., Dos Remedios, C., et al (2014). Genome-Wide Identification of Expression Quantitative Trait Loci (eQTLs) in Human Heart. PloS One, 9(5), 1-11. [More Information]

2013

Li, A., Estigoy, C., Raftery, M., Cameron, D., Odeberg, J., Ponten, F., Lal, S., Dos Remedios, C. (2013). Heart Research Advances Using Database Search Engines, Human Protein Atlas and the Sydney Heart Bank. Heart, Lung, and Circulation, 22(10), 819-826. [More Information]

2011

Cahill, H., Jones, A., Herkes, R., Cook, K., Stirling, A., Halbert, T., Yates, A., Lal, S., Gardo, A., Donnelly, R., Gattas, D. (2011). Introduction of a new observation chart and education programme is associated with higher rates of vital-sign ascertainment in hospital wards. BMJ Quality and Safety, 20(9), 791-796. [More Information]
Wolfe, J., Ishiwata, S., Braet, F., Whan, R., Su, Y., Lal, S., Dos Remedios, C. (2011). SPontaneous Oscillatory Contraction (SPOC): auto-oscillations observed in striated muscle at partial activation. Biophysical Reviews, 3(2), 53-62. [More Information]

2010

Mohamed, A., Lal, S., Ho, J., Brown, A., Lui, R., Nguyen, L., Yong, A., Su, Y., Braet, F., Dyer, W., Junius, F., Cumming, R., Freedman, B., Kritharides, L., Dos Remedios, C. (2010). How to interrogate the cellular immune system in patients with ischemic heart disease. In Dmitry Vukovic & Vladimir Kiyan (Eds.), Myocardial ischemia: Causes, symptoms and treatment, (pp. 195-216). United States: Nova Science Publishers.
Lal, S., Dos Remedios, C. (2010). Is There a Connection between Ablation of Atrial Fibrillation and Reduced Apoptosis? Cardiology, 117(3), 161-2. [More Information]

2009

Lal, S., Brown, A., Nguyen, L., Braet, F., Dyer, W., Dos Remedios, C. (2009). Using antibody arrays to detect microparticles from acute coronary syndrome patients based on Cluster of Differentiation (CD) antigen expression. Molecular and Cellular Proteomics, 8(4), 799-804. [More Information]

2004

Lal, S., Lui, R., Nguyen, L., Macdonald, P., Denyer, G., Dos Remedios, C. (2004). Increases In Leukocyte Cluster Of Differentiation Antigen Expression During Cardiopulmonary Bypass In Patients Undergoing Heart Transplantation. Proteomics, 4(7), 1918-1926. [More Information]

2002

Lal, S., Christopherson, R., Dos Remedios, C. (2002). Antibody arrays: an embryonic but rapidly growing technology. Drug Discovery Today, 7(18 Supplement), S143-S149. [More Information]

Selected Grants

2024

Augmenting Intrinsic Human Cardiac Regeneration to ReverseHeart Failure, Lal S, Royal Australasian College of Physicians/Career Development Fellowship
Research Grant to support research in the field of cardiovascular - The Baird Institute Limited, Lal S, The Baird Institute/Research Grant, Lal S, The Baird Institute/Research Grant
Novel therapeutic strategies to preserve heart function after heart attack, Witting P, Lal S, Kritharides L, National Heart Foundation of Australia/Vanguard Grant

2023

Replenishing enzymatic cofactor NAD in Heart Failure: Rescuing an "engine out of fuel", O'Sullivan J, Lal S, Koay Y, Philp A, Department of Health and Aged Care (Federal - administered by NHMRC)/Cardiovascular Health Mission - 2022 Cardiovascular Health Grant

2022

Mechanisms of Cardiac Ageing and Heart Failure: Creating a Human Heart Map, Lal S, The Trustee for RICHARD THOMAS HALL ESTATE/Research Grant

2021

Digital solutions for heart failure best practice care, Keech A, Lal S, Macdonald P, Ferguson C, Ryan C, Jenkins A, Dempsey K, O'Connell R, Kilov G, Department of Health and Aged Care (Federal)/MRFF - Cardiovascular Health Mission
Cell and sex-specific drivers of diabetic cardiomyopathy, Lal S, Diabetes Australia/Research Grant

2019

MRI and Metabolomic Correlates in Diabetic Cardiomyopathy, Lal S, Cardiac Society of Australia & New Zealand (CSANZ)/Research Grant

2017

Developing experimental alternatives to animal models using human heart tissue, Lal S, Li A, Dos Remedios C, Medical Advances Without Animals (MAWA)/Research Grant

2015

The Sydney Human Heart Bank: A resource that eliminates the use of animals in research, Dos Remedios C, King D, Lal S, Li A, Medical Advances Without Animals (MAWA)/Research Grant

In the media

https://www.sydney.edu.au/news-opinion/news/2021/05/04/understanding-heart-failure.html

Faculty of Medicine and Health

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Associate Professor Sean Lal

The Sydney Heart Bank (SHB)

Executive & Scientific Review Board

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Sydney Heart Bank User Policy

Publications

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Selected Grants

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2023

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2021

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In the media

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