People_

Dr Alistair Senior

ARC Future Fellow

Phone

0286270703

alistair.senior@sydney.edu.au

Address

D17 - Charles Perkins Centre

The University of Sydney

Details

Member of the Charles Perkins Centre

Websites

Personal Website

Google Scholar

Biographical details

I am from the UK, where I did my undergraduate and master's degrees in Biological sciences and evolutionary biology, respectively. In 2010 I moved to the University of Otago in New Zealand where I did my PhD in the Zoology Department under the supervision of Shinichi Nakagawa, graduating in 2013.

Research interests

I am primarily work in the field of nutritional ecology.

Nutritional ecology seeks to understand how interactions between an organism and its nutritional environment give rise to state of health, function and, ultimately, evolutionary fitness. Most recently I have become interested in the effects of diet on mortality and lifespan.

I am more interested in questions than methodsper se. My research uses all kinds of systems ranging from the theoretical (e.g., mathematical and computational models), to the experimental (e.g., animal experiments) and ecological (e.g., observational/epidemiological data). However, I have a particular interest in meta-analysis, a domain where my expertise extends to methods development.

We know surprisingly little about how diets and nutritional strategies change over evolutionary time. However, these traits fundamentally influence physiological adaptation and ultimately health. Perhaps our ability to understand these phenomena has been hampered by a lack of nutritional thinking. My research demonstrates that nutritional approaches can provide novel insights into the way that organisms adapt to their environments, and ultimately, I hope, give a new understanding of the evolutionary basis for diet, appetite and disease

Teaching and supervision

I offer student projects on experimental nutritional biology, meta-analysis, comparative analysis and computational simulation, usually with applications to questions in nutritional ecology and evolutionary biology.

If you are interested in contributing to a project of this nature, please feel free to send me an email.

Current projects

Genetic moderators of life-history responses to diet.

The theoretical basis for protein leverage in humans.

Macronutrients and age-specific mortality.

Novel meta-analytic effect sizes for estimating biological variability.

Themes

Ecology and Evolution, Food and nutrition, Human health

Current research students

Project title	Research student
Food supply, nutrient intake, and healthy ageing: Global population analyses	Caitlin ANDREWS
Using lessons from machine learning to construct a new evolutionary theory of aging	Christopher BARKER

Publications

By Type

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Journals

Ni, D., Senior, A., Raubenheimer, D., Simpson, S., Nanan, R. (2025). High-Fat and Low-Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and Prevalence. Annals of Clinical and Translational Neurology. [More Information]
Liu, R., Senior, A., Bao, Z., Koay, Y., Holmes, A., O'Sullivan, J. (2025). Multi-organ multi-omic and gut microbiome signatures of fat and sucrose dietary oversupply in cardiometabolic disease. iScience, 28(4), 111887. [More Information]
Farris, K., Senior, A., Sobreira, D., Mitchell, R., Weber, Z., Ingerslev, L., Barrès, R., Simpson, S., Crean, A., Nobrega, M. (2024). Dietary macronutrient composition impacts gene regulation in adipose tissue. Communications Biology, 7(1). [More Information]
Ni, D., Senior, A., Raubenheimer, D., Simpson, S., Macia, L., Nanan, R. (2024). Global associations of macronutrient supply and asthma disease burden. European Journal of Immunology, 54(Suppl 1), 566-566. [More Information]
Ni, D., Senior, A., Raubenheimer, D., Simpson, S., Macia, L., Nanan, R. (2024). Global associations of macronutrient supply and asthma disease burden. Allergy, 79(7), 1989-1991. [More Information]
Ni, D., Tan, J., Reyes, J., Senior, A., Andrews, C., Taitz, J., Potier, C., Wishart, C., Spiteri, A., Piccio, L., King, N., Simpson, S., Nanan, R., Macia, L. (2024). High fat low carbohydrate is linked to protection against the development of CNS autoimmunity. European Journal of Immunology, 54(1), 230-230. [More Information]
Ni, D., Senior, A., Tan, J., Macia, L., Nanan, R. (2024). How nutritional landscapes impact food allergy. European Journal of Immunology, 54(Suppl 1), 567-567. [More Information]
Ni, D., Senior, A., Tan, J., Macia, L., Nanan, R. (2024). Linking Macronutrient Composition of Common Allergenic Foods to European and North American Food Allergy Prevalence. Clinical and Experimental Allergy. [More Information]
Crean, A., Pulpitel, T., Pini, T., Rickard, J., de Graaf, S., Senior, A., Simpson, S., Wali, J. (2024). Low-Fat, High-Carbohydrate Diets Reduce Body Weight and Sperm Count but Increase Sperm Motility in Mice. The Journal of Nutrition, 154(1), 60-68. [More Information]
Koemel, N., Laouali, N., Skilton, M., Shah, S., Senior, A., Severi, G., Mancini, F., Gill, T., Simpson, S., Raubenheimer, D., et al (2024). Macronutrient composition of plant-based diets and breast cancer risk: the E3N prospective cohort study. European Journal of Nutrition, 63(5), 1771-1781. [More Information]
Zaman, K., Mun, H., Solon-Biet, S., Senior, A., Raubenheimer, D., Simpson, S., Conigrave, A. (2024). Mice Regulate Dietary Amino Acid Balance and Energy Intake by Selecting between Complementary Protein Sources. The Journal of Nutrition, 154(6), 1766-1780. [More Information]
Ribeiro, R., Senior, A., Simpson, S., Tan, J., Raubenheimer, D., Le Couteur, D., Macia, L., Holmes, A., Eberhard, J., O'Sullivan, J., Koay, Y., Kanjrawi, A., Yang, J., Kim, T., Gosby, A. (2024). Rapid benefits in older age from transition to whole food diet regardless of protein source or fat to carbohydrate ratio: Arandomised control trial. Aging Cell, 23(11), e14276. [More Information]
Koemel, N., Laouali, N., Senior, A., Celermajer, D., Grech, A., Solon-Biet, S., Simpson, S., Raubenheimer, D., Gill, T., Skilton, M. (2024). The Relationship between Dietary Macronutrient Composition and Telomere Length Among US Adults. Advanced Biology, 8(4). [More Information]
Nakagawa, S., Noble, D., Lagisz, M., Spake, R., Viechtbauer, W., Senior, A. (2023). A robust and readily implementable method for the meta-analysis of response ratios with and without missing standard deviations. Ecology Letters, 26(2), 232-244. [More Information]
Wali, J., Ni, D., Facey, H., Dodgson, T., Pulpitel, T., Senior, A., Raubenheimer, D., Macia, L., Simpson, S. (2023). Determining the metabolic effects of dietary fat, sugars and fat-sugar interaction using nutritional geometry in a dietary challenge study with male mice. Nature Communications, 14(1). [More Information]
Das, S., Silver, R., Senior, A., Gilhooly, C., Bhapkar, M., Le Couteur, D. (2023). Diet composition, adherence to calorie restriction, and cardiometabolic disease risk modification. Aging Cell, 22(12), e14018. [More Information]
Koemel, N., Senior, A., Benmarhnia, T., Holmes, A., Okada, M., Oulhote, Y., Parker, H., Shah, S., Simpson, S., Raubenheimer, D., Gill, T., Skilton, M., et al (2023). Diet Quality, Microbial Lignan Metabolites, and Cardiometabolic Health among US Adults. Nutrients, 15(6). [More Information]
Senior, A. (2023). Estimating Genetic Variance in Life-Span Response to Diet: Insights From Statistical Simulation. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 78(3), 392-396. [More Information]
Saner, C., Senior, A., Zhang, H., Eloranta, A., Magnussen, C., Sabin, M., Juonala, M., Janner, M., Burgner, D., Schwab, U., Heitmann, B., Simpson, S., Raubenheimer, D., et al (2023). Evidence for protein leverage in a general population sample of children and adolescents. European Journal of Clinical Nutrition. [More Information]
Honfo, S., Senior, A., Legault, V., Presse, N., Turcot, V., Gaudreau, P., Simpson, S., Raubenheimer, D., Cohen, A. (2023). Evidence for protein leverage on total energy intake, but not body mass index, in a large cohort of older adults. International Journal of Obesity. [More Information]
Zhang, H., Senior, A., Saner, C., Olsen, N., Larsen, S., Simpson, S., Raubenheimer, D., Heitmann, B. (2023). Evidence for the protein leverage hypothesis in preschool children prone to obesity. Clinical Nutrition, 42(11), 2249-2257. [More Information]
Koemel, N., Senior, A., Celermajer, D., Grech, A., Gill, T., Simpson, S., Raubenheimer, D., Skilton, M. (2023). Multi-Nutrient Analysis of Dietary Macronutrients with All-Cause, Cardiovascular, and Cancer Mortality: Data from NHANES 1999–2014. Nutrients, 15(2). [More Information]
Lai, M., Li, A., Senior, A., Neely, G., Simpson, S., Wang, Q. (2023). Nutritional geometry framework of sleep. Life Sciences, 316. [More Information]
Nakagawa, S., Lagisz, M., O'Dea, R., Pottier, P., Rutkowska, J., Senior, A., Yang, Y., Noble, D. (2023). orchaRd 2.0: An R package for visualising meta-analyses with orchard plots. Methods in Ecology and Evolution, 14(8), 2003-2010. [More Information]
Solon-Biet, S., Clark, X., Bell-Anderson, K., Rusu, P., Perks, R., Freire, T., Pulpitel, T., Senior, A., Hoy, A., Aung, O., Le Couteur, D., Raubenheimer, D., Conigrave, A., Simpson, S., et al (2023). Toward reconciling the roles of FGF21 in protein appetite, sweet preference, and energy expenditure. Cell Reports, 42(12). [More Information]
Wang, T., Kroeger, C., Cassidy, S., Mitra, S., Ribeiro, R., Jose, S., Masedunskas, A., Senior, A., Fontana, L. (2023). Vegetarian Dietary Patterns and Cardiometabolic Risk in People With or at High Risk of Cardiovascular Disease: A Systematic Review and Meta-analysis. JAMA Network Open, 6(7), e2325658. [More Information]
Nakagawa, S., Senior, A., Viechtbauer, W., Noble, D. (2022). An assessment of statistical methods for non-independent data in ecological meta-analyses: Comment. Ecology, 103(1), 1-5. [More Information]
Raubenheimer, D., Senior, A., Mirth, C., Cui, Z., Hou, R., Le Couteur, D., Solon-Biet, S., Léopold, P., Simpson, S. (2022). An integrative approach to dietary balance across the life course. iScience, 25(5). [More Information]
Tan, J., Ni, D., Taitz, J., Pinget, G., Read, M., Senior, A., Wali, J., Elnour, R., Shanahan, E., Wu, H., Chadban, S., Nanan, R., King, N., Grau, G., Simpson, S., Macia, L. (2022). Dietary protein increases T-cell-independent sIgA production through changes in gut microbiota-derived extracellular vesicles. Nature Communications, 13(1), 4336-1-4336-15. [More Information]
Havula, E., Ghazanfar, S., Lamichane, N., Francis, D., Hasygar, K., Liu, Y., Alton, L., Johnstone, J., Needham, E., Pulpitel, T., Clark, T., Niranjan, H., Shang, V., Tong, V., Jiwnani, N., Audia, G., Neely, G., Yang, J., Simpson, S., Senior, A., et al (2022). Genetic variation of macronutrient tolerance in Drosophila melanogaster. Nature Communications, 13(1637), 1-16. [More Information]
Raynal, R., Noble, D., Riley, J., Senior, A., Warner, D., While, G., Schwanz, L. (2022). Impact of fluctuating developmental temperatures on phenotypic traits in reptiles: a meta-analysis. Journal of Experimental Biology, 225(1), jeb243369. [More Information]
Koemel, N., Senior, A., Dissanayake, H., Ross, J., McMullan, R., Kong, Y., Phang, M., Hyett, J., Raubenheimer, D., Gordon, A., Simpson, S., Skilton, M. (2022). Maternal dietary fatty acid composition and newborn epigenetic aging-a geometric framework approach. American Journal of Clinical Nutrition, 115(1), 118-127. [More Information]
Solon-Biet, S., Griffiths, L., Fosh, S., Le Couteur, D., Simpson, S., Senior, A. (2022). Meta-analysis links dietary branched-chain amino acids to metabolic health in rodents. BMC Biology, 20(1), 19. [More Information]
Senior, A., Legault, V., Lavoie, F., Presse, N., Gaudreau, P., Turcot, V., Raubenheimer, D., Le Couteur, D., Simpson, S., Cohen, A. (2022). Multidimensional associations between nutrient intake and healthy ageing in humans. BMC Biology, 20(1), Article 196-17 pages. [More Information]
Clark, T., Crean, A., Senior, A. (2022). Obesogenic diets induce anxiety in rodents: a systematic review and meta-analysis. Obesity Reviews, 23(3), 1-7. [More Information]
Campbell, G., Lucic-Fisher, S., Brandon, A., Senior, A., Bell-Anderson, K. (2022). Sex-specific effects of maternal dietary carbohydrate quality on fetal development and offspring metabolic phenotype in mice. Frontiers in Nutrition, 9. [More Information]
Nelson, M., Madsen, S., Cooke, K., Fritzen, A., Thorius, I., Masson, S., carroll, L., Weiss, F., Seldin, M., Potter, M., Hocking, S., Fazakerley, D., Brandon, A., Thillainadesan, S., Senior, A., Cooney, G., Stoeckli, J., James, D. (2022). Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance. Cell Metabolism, 34(2), 227-239.e6. [More Information]
Senior, A., Raubenheimer, D., Simpson, S. (2022). Testing the protein-leveragehypothesis using population surveillance data. Royal Society Open Science, 9, 220756-1-220756-15. [More Information]
Wali, J., Raubenheimer, D., Senior, A., Le Couteur, D., Simpson, S. (2021). Cardio-metabolic consequences of dietary carbohydrates: reconciling contradictions using nutritional geometry. Cardiovascular Research, 117(2), 386-401. [More Information]
Tan, J., Ni, D., Wali, J., Cox, D., Pinget, G., Taitz, J., Daien, C., Senior, A., Read, M., Simpson, S., King, N., Macia, L. (2021). Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function. iScience, 24(8), 102835. [More Information]
Francis, D., Ghazanfar, S., Havula, E., Krycer, J., Strbenac, D., Senior, A., Minard, A., Geddes, T., Nelson, M., Weiss, F., Stoeckli, J., Yang, J., James, D. (2021). Genome-wide analysis in Drosophila reveals diet-by-gene interactions and uncovers diet-responsive genes. G3: Genes, Genomes, Genetics, 11(10), jkab171. [More Information]
Noble, D., Senior, A., Uller, T., Schwanz, L. (2021). Heightened among-individual variation in life history but not morphology is related to developmental temperature in reptiles. Journal of Evolutionary Biology, 34(11), 1793-1802. [More Information]
Wali, J., Milner, A., Luk, A., Pulpitel, T., Dodgson, T., Facey, H., Wahl, D., Kebede, M., Senior, A., Sullivan, M., Brandon, A., Yau, B., Lockwood, G., Koay, Y., Ribeiro, R., Solon-Biet, S., Bell-Anderson, K., O'Sullivan, J., Macia, L., Cooney, G., Cogger, V., Holmes, A., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2021). Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health. Nature Metabolism, 3(6), 810-828. [More Information]
Usui, T., Macleod, M., McCann, S., Senior, A., Nakagawa, S. (2021). Meta-analysis of variation suggests that embracing variability improves both replicability and generalizability in preclinical research. PLoS Biology, 19(5), e3001009. [More Information]
Le Couteur, D., Solon-Biet, S., Parker, B., Pulpitel, T., Brandon, A., Hunt, N., Wali, J., Gokarn, R., Senior, A., Cooney, G., Raubenheimer, D., James, D., Simpson, S., et al (2021). Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin. Cell Metabolism, 33(12), 2367-2379.e4. [More Information]
Norris, D., Yang, P., Shin, S., Kearney, A., Kim, H., Geddes, T., Senior, A., Fazakerley, D., Nguyen, L., James, D., Burchfield, J. (2021). Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression. iScience, 24(2), 102118. [More Information]
Koemel, N., Senior, A., Dissanayake, H., Raubenheimer, D., Simpson, S., Skilton, M. (2021). THE IMPACT OF MATERNAL DIETARY FATTY ACIDS ON NEWBORN CARDIOMETABOLIC RISK. Journal of the American College of Cardiology, 77(18), 1479. [More Information]
Nakagawa, S., Lagisz, M., O'Dea, R., Rutkowska, J., Yang, Y., Noble, D., Senior, A. (2021). The orchard plot: Cultivating a forest plot for use in ecology, evolution, and beyond. Research Synthesis Methods, 12(1), 4-12. [More Information]
Myers, J., Senior, A., Zadmajid, V., Sørensen, S., Butts, I. (2020). Associations between Ovarian Fluid and Sperm Swimming Trajectories in Marine and Freshwater Teleosts: A Meta-Analysis. Reviews in Fisheries Science & Aquaculture, 28(3), 322-339. [More Information]
Le Couteur, D., Ribeiro, R., Senior, A., Hsu, B., Hirani, V., Blyth, F., Waite, L., Simpson, S., Naganathan, V., Cumming, R., et al (2020). Branched Chain Amino Acids, Cardiometabolic Risk Factors and Outcomes in Older Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(10), 1805-1810. [More Information]
Yue, K., Jarvie, S., Senior, A., Van Meerbeek, K., Peng, Y., Ni, X., Wu, F., Svenning, J. (2020). Changes in plant diversity and its relationship with productivity in response to nitrogen addition, warming and increased rainfall. Oikos, 129(7), 939-952. [More Information]
Rodriguez Paris, V., Solon-Biet, S., Senior, A., Edwards, M., Desai, R., Tedla, N., Cox, M., Ledger, W., Gilchrist, R., Simpson, S., Handelsman, D., Walters, K. (2020). Defining the impact of dietary macronutrient balance on PCOS traits. Nature Communications, 11(1), 5262. [More Information]
Saner, C., Tassoni, D., Harcourt, B., Kao, K., Alexander, E., McCallum, Z., Olds, T., Rowlands, A., Burgner, D., Simpson, S., Raubenheimer, D., Senior, A., et al (2020). Evidence for Protein Leverage in Children and Adolescents with Obesity. Obesity, 28(4), 822-829. [More Information]
Senior, A., Nakagawa, S., Raubenheimer, D., Simpson, S. (2020). Global associations between macronutrient supply and age-specific mortality. Proceedings of the National Academy of Sciences of the United States of America, 117(48), 30824-30835. [More Information]
Cohen, A., Kennedy, B., Anglas, U., Bronikowski, A., Deelen, J., Dufour, F., Ferbeyre, G., Ferrucci, L., Franceschi, C., Frasca, D., Senior, A., et al (2020). Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mechanisms of Ageing and Development, 191, 111316. [More Information]
Xu, X., Solon-Biet, S., Senior, A., Raubenheimer, D., Simpson, S., Fontana, L., Mueller, S., Yang, J. (2020). LC-N2G: a local consistency approach for nutrigenomics data analysis. BMC Bioinformatics, 21(1), 530. [More Information]
Genoud, S., Senior, A., Hare, D., Double, K. (2020). Meta-Analysis of Copper and Iron in Parkinson's Disease Brain and Biofluids. Movement Disorders, 35(4), 662-671. [More Information]
Senior, A., Viechtbauer, W., Nakagawa, S. (2020). Revisiting and expanding the meta-analysis of variation: The log coefficient of variation ratio. Research Synthesis Methods, 11(4), 553-567. [More Information]
Freire, T., Senior, A., Perks, R., Pulpitel, T., Clark, X., Brandon, A., Wahl, D., Hatchwell, L., Le Couteur, D., Cooney, G., Larance, M., Simpson, S., Solon-Biet, S. (2020). Sex-specific metabolic responses to 6 hours of fasting during the active phase in young mice. Journal of Physiology, 598(11), 2081-2092. [More Information]
Zajitschek, S., Zajitschek, F., Bonduriansky, R., Brooks, R., Cornwell, W., Falster, D., Lagisz, M., Mason, J., Senior, A., Noble, D., et al (2020). Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications. eLife, 9, 1-17. [More Information]
Pawelec, G., Bronikowski, A., Cunnane, S., Ferrucci, L., Franceschi, C., Fülöp, T., Gaudreau, P., Gladyshev, V., Gonos, E., Gorbunova, V., Senior, A., et al (2020). The conundrum of human immune system “senescence”. Mechanisms of Ageing and Development, 192, 1-8. [More Information]
Solon-Biet, S., Cogger, V., Pulpitel, T., Wahl, D., Clark, X., Bagley, E., Gregoriou, G., Senior, A., Wang, Q., Brandon, A., Perks, R., O'Sullivan, J., Koay, Y., Bell-Anderson, K., Kebede, M., Yau, B., Atkinson, C., Dodgson, T., Wali, J., Raubenheimer, D., Cooney, G., Le Couteur, D., Simpson, S., et al (2019). Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature Metabolism, 1(5), 532-545. [More Information]
Senior, A., Solon-Biet, S., Cogger, V., Le Couteur, D., Nakagawa, S., Raubenheimer, D., Simpson, S. (2019). Dietary macronutrient content, age-specific mortality and lifespan. Proceedings of the Royal Society B: Biological Sciences, 286(1902), 1-9. [More Information]
Gwynn, J., Sim, K., Searle, T., Senior, A., Lee, A., Brimblecombe, J. (2019). Effect of nutrition interventions on diet-related and health outcomes of Aboriginal and Torres Strait Islander Australians: a systematic review. BMJ Open, 9(4), 1-15. [More Information]
Nie, Y., Wei, F., Zhou, W., Hu, Y., Senior, A., Wu, Q., Yan, L., Raubenheimer, D. (2019). Giant pandas are macronutritional carnivores. Current Biology, 29(10), 1677-1682.e2. [More Information]
Crean, A., Senior, A. (2019). High-fat diets reduce male reproductive success in animal models: A systematic review and meta-analysis. Obesity Reviews, 20(6), 921-933. [More Information]
Hosking, C., Raubenheimer, D., Charleston, M., Simpson, S., Senior, A. (2019). Macronutrient intakes and the lifespan-fecundity trade-off: a geometric framework agent-based model. Journal of the Royal Society Interface, 16(151), 1-13. [More Information]
Ribeiro, R., Solon-Biet, S., Pulpitel, T., Senior, A., Cogger, V., Clark, X., O'Sullivan, J., Koay, Y., Hirani, V., Blyth, F., Seibel, M., Naganathan, V., Cumming, R., Handelsman, D., Simpson, S., Le Couteur, D., et al (2019). Of older mice and men: Branched-chain amino acids and body composition. Nutrients, 11(8), 1-11. [More Information]
Thieltges, D., Goedknegt, M., O'Dwyer, K., Senior, A., Kamiya, T. (2019). Parasites and stable isotopes: a comparative analysis of isotopic discrimination in parasitic trophic interactions. Oikos, 128(9), 1329-1339. [More Information]
Morimoto, J., Senior, A., Ruiz, K., Wali, J., Pulpitel, T., Solon-Biet, S., Cogger, V., Raubenheimer, D., Le Couteur, D., Simpson, S., Eberhard, J. (2019). Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis. PloS One, 14(3), 1-10. [More Information]
Mijatovic, J., Capling, A., Cheng, S., Stamatakis, E., Louie, J., Cheung, N., Markovic, T., Ross, G., Senior, A., Brand-Miller, J., Flood, V. (2018). Associations of diet and physical activity with risk for gestational diabetes mellitus: A Systematic review and meta-analysis. Nutrients, 10(6). [More Information]
Wahl, D., Solon-Biet, S., Wang, K., Wali, J., Pulpitel, T., Clark, X., Raubenheimer, D., Senior, A., Sinclair, D., Cooney, G., Cogger, V., Simpson, S., Le Couteur, D., et al (2018). Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Reports, 25(8), 2234-2243.e6. [More Information]
Grueber, C., Gray, L., Morris, K., Simpson, S., Senior, A. (2018). Intergenerational effects of nutrition on immunity: a systematic review and meta-analysis. Biological Reviews, 93(2), 1108-1124. [More Information]
Ngo, T., Senior, A., Culina, A., Santos, E., Vlak, J., Zwart, M. (2018). Quantitative analysis of the dose–response of white spot syndrome virus in shrimp. Journal of Fish Diseases, 41(11), 1733-1744. [More Information]
Machovsky-Capuska, G., Miller, M., Silva, F., Amiot, C., Stockin, K., Senior, A., Schuckard, R., Melville, D., Raubenheimer, D. (2018). The nutritional nexus: Linking niche, habitat variability and prey composition in a generalist marine predator. Journal of Animal Ecology, 87(5), 1286-1298. [More Information]
Lihoreau, M., Charleston, M., Senior, A., Clissold, F., Raubenheimer, D., Simpson, S., Buhl, J. (2017). Collective foraging in spatially complex nutritional environments. Philosophical Transactions of the Royal Society B: Biological Sciences, 372(1727), Art. 20160238-1-Art. 20160238-11. [More Information]
Ribeiro, R., Hirani, V., Senior, A., Gosby, A., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Handelsman, D., Kendig, H., Seibel, M., Simpson, S., Stanaway, F., Allman-Farinelli, M., Le Couteur, D. (2017). Diet quality and its implications on the cardio-metabolic, physical and general health of older men: the Concord Health and Ageing in Men Project (CHAMP). British Journal of Nutrition, 118, 130-143. [More Information]
Senior, A., Nakagawa, S., Raubenheimer, D., Simpson, S., Noble, D. (2017). Dietary restriction increases variability in longevity. Biology Letters, 13(3), 1-4. [More Information]
Wong, A., Wang, Q., Morimoto, J., Senior, A., Lihoreau, M., Neely, G., Simpson, S., Ponton, F. (2017). Gut Microbiota Modifies Olfactory-Guided Microbial Preferences and Foraging Decisions in Drosophila. Current Biology, 27(15), 2397-2404. [More Information]
Coogan, S., Machovsky-Capuska, G., Senior, A., Martin, J., Major, R., Raubenheimer, D. (2017). Macronutrient selection of free-ranging urban Australian white ibis (Threskiornis moluccus). Behavioural Ecology, 28(4), 1021-1029. [More Information]
Nakagawa, S., Noble, D., Senior, A., Lagisz, M. (2017). Meta-evaluation of meta-analysis: Ten appraisal questions for biologists. BMC Biology, 15(1), 1-14. [More Information]
Campbell, G., Senior, A., Bell-Anderson, K. (2017). Metabolic Effects of High Glycaemic Index Diets: A Systematic Review and Meta-Analysis of Feeding Studies in Mice and Rats. Nutrients, 9(7), 1-20. [More Information]
Senior, A., Lihoreau, M., Charleston, M., Buhl, J., Raubenheimer, D., Simpson, S. (2016). Adaptive collective foraging in groups with conflicting nutritional needs. Royal Society Open Science, 3(4), 1-15. [More Information]
Senior, A., Lim, J., Adolfsson, S., Lamatsch, D., Nagakawa, S. (2016). Condition and reproductive investment in the western mosquitofish (Gambusia affinis): little evidence for condition-dependent sex-biased investment. Biological Journal of the Linnean Society, 119(2), 430-435. [More Information]
Cogger, V., Mohamad, M., Solon-Biet, S., Senior, A., Warren, A., O'Reilly, J., Tung, B., Svistounov, D., McMahon, A., Fraser, R., Raubenheimer, D., Holmes, A., Simpson, S., Le Couteur, D. (2016). Dietary Macronutrients and the Aging Liver Sinusoidal Endothelial Cell. American Journal of Physiology - Heart and Circulatory Physiology, 310(9), H1064-H1070. [More Information]
Machovsky-Capuska, G., Senior, A., Zantis, S., Barna, K., Cowieson, A., Panyda, S., Pavard, C., Shiels, M., Raubenheimer, D. (2016). Dietary protein selection in a free-ranging urban population of common myna birds. Behavioral Ecology, 27(1), 219-227. [More Information]
Besson, A., Lagisz, M., Senior, A., Hector, K., Nagakawa, S. (2016). Effect of maternal diet on offspring coping styles in rodents: a systematic review and meta-analysis. Biological Reviews, 91(4), 1065-1080. [More Information]
Vanderpham, J., Nakagawa, S., Senior, A., Closs, G. (2016). Habitat-related specialization of lateral-line system morphology in a habitat-generalist and a habitat-specialist New Zealand eleotrid. Journal of Fish Biology, 88(4), 1631-1641. [More Information]
Senior, A., Grueber, C., Kamiya, T., Lagisz, M., O'Dwyer, K., Santos, E., Nakagawa, S. (2016). Heterogeneity in ecological and evolutionary meta-analyses: its magnitude and implications. Ecology, 97(12), 3293-3299. [More Information]
Jones, P., Senior, A., Allibone, R., Closs, G. (2016). Life-history variation in a species complex of nonmigratory galaxiids. Ecology of Freshwater Fish, 25(2), 174-189. [More Information]
Senior, A., Grueber, C., Machovsky-Capuska, G., Simpson, S., Raubenheimer, D. (2016). Macronutritional consequences of food generalism in an invasive mammal, the wild boar. Mammalian Biology, 81(5), 523-526. [More Information]
Senior, A., Gosby, A., Lu, J., Simpson, S., Raubenheimer, D. (2016). Meta-analysis of variation: an illustration comparing the effects of two dietary interventions on variability in weight. Evolution, Medicine and Public Health, 2016 (1), 244-255. [More Information]
Geoghegan, J., Senior, A., Holmes, E. (2016). Pathogen population bottlenecks and adaptive landscapes: overcoming the barriers to disease emergence. Proceedings of the Royal Society B: Biological Sciences, 283(1837), 1-9. [More Information]
Machovsky-Capuska, G., Senior, A., Benn, E., Tait, A., Schuckard, R., Stockin, K., Cook, W., Ogle, M., Barna, K., Melville, D., Wright, B., Raubenheimer, D., et al (2016). Sex-specific macronutrient foraging strategies in a highly successful marine predator: the Australasian gannet. Marine Biology, 163(4), 1-14. [More Information]
Senior, A., Lihoreau, M., Buhl, J., Raubenheimer, D., Simpson, S. (2016). Social Network Analysis and Nutritional An Integrated Modelling Approach. Frontiers in Psychology, 7, 1-10. [More Information]
Senior, A., Johnson, S., Nakagawa, S. (2016). Sperm traits of masculinized fish relative to wild-type males: a systematic review and meta-analyses. Fish and Fisheries, 17(1), 143-164. [More Information]
Le Couteur, D., Solon-Biet, S., Cogger, V., Mitchell, S., Senior, A., de Cabo, R., Raubenheimer, D., Simpson, S. (2016). The impact of low-protein high-carbohydrate diets on aging and lifespan. Cellular and Molecular Life Sciences, 73(6), 1237-1252. [More Information]
Machovsky-Capuska, G., Senior, A., Simpson, S., Raubenheimer, D. (2016). The Multidimensional Nutritional Niche. Trends in Ecology and Evolution, 31(5), 355-365. [More Information]
Geoghegan, J., Senior, A., Di Giallonardo, F., Holmes, E. (2016). Virological factors that increase the transmissibility of emerging human viruses. Proceedings of the National Academy of Sciences of the United States of America, 113(15), 4170-4175. [More Information]
Lamatsch, D., Adolfsson, S., Senior, A., Christiansen, G., Pichler, M., Ozaki, Y., Smeds, L., Schartl, M., Nakagawa, S. (2015). A Transcriptome Derived Female-Specific Marker from the Invasive Western Mosquitofish (Gambusia affinis). PloS One, 10(2), 1-16. [More Information]
Senior, A., Nakagawa, S., Lihoreau, M., Simpson, S., Raubenheimer, D. (2015). An Overlooked Consequence of Dietary Mixing: A Varied Diet Reduces Interindividual Variance in Fitness. The American Naturalist, 186(5), 649-659. [More Information]
Jarvie, S., Senior, A., Adolph, S., Seddon, P., Cree, A. (2015). Captive rearing affects growth but not survival in translocated juvenile tuatara. Journal of Zoology, 297(3), 184-193. [More Information]
Senior, A., Lokman, P., Gloss, G., Nakagawa, S. (2015). Ecological and evolutionary applications for environmental sex reversal of fish. The Quarterly Review of Biology, 90(1), 23-44. [More Information]
Senior, A., Charleston, M., Lihoreau, M., Buhl, J., Raubenheimer, D., Simpson, S. (2015). Evolving nutritional strategies in the presence of competition: A geometric agent-based model. PLoS Computational Biology, 11(3), 1-24. [More Information]
Nakagawa, S., Poulin, R., Mengersen, K., Reinhold, K., Engqvist, L., Lagisz, M., Senior, A. (2015). Meta-analysis of variation: Ecological and evolutionary applications and beyond. Methods in Ecology and Evolution, 6, 143-152. [More Information]
Grueber, C., Knafler, G., King, T., Senior, A., Grosser, S., Robertson, B., Weston, K., Brekke, P., Harris, C., Jamieson, I. (2015). Toll-like receptor diversity in 10 threatened bird species: relationship with microsatellite heterozygosity. Conservation Genetics, 16, 595-611. [More Information]
Kamiya, T., O'Dwyer, K., Westerdahl, H., Senior, A., Nakagawa, S. (2014). A quantitative review of MHC-based mating preference: the role of diversity and dissimilarity. Molecular Ecology, 23(21), 5151-5163. [More Information]
Schadewinkel, R., Senior, A., Wilson, D., Jamieson, I. (2014). Effects on South Island robins (Petroica australis) from pest control using aerially applied 1080 poison. New Zealand Journal of Ecology, 38(2), 315-321.
Lim, J., Senior, A., Nakagawa, S. (2014). Heterogeneity in individual quality and reproductive trade-offs within species. Evolution, 68(8), 2306-2318. [More Information]
Senior, A., Nakagawa, S., Grimm, V. (2014). The Evolutionary Consequences of Disrupted Male Mating Signals: An Agent-Based Modelling Exploration of Endocrine Disrupting Chemicals in the Guppy. PloS One, 9(7), 1-9. [More Information]
Senior, A., Nakagawa, S. (2013). A comparative analysis of chemically induced sex reversal in teleosts: challenging conventional suppositions. Fish and Fisheries, 14(1), 60-76. [More Information]
Senior, A., Krkosek, M., Nakagawa, S. (2013). The practicality of Trojan sex chromosomes as a biological control: an agent based model of two highly invasive Gambusia species. Biological Invasions, 15(8), 1765-1782. [More Information]
Senior, A., Nat Lim, J., Nakagawa, S. (2012). The fitness consequences of environmental sex reversal in fish: a quantitative review. Biological Reviews, 87(4), 900-911. [More Information]

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Conferences

Senior, A., Nakagawa, S., Grimm, V. (2013). Exploring the Evolutionary Consequences of chemically disrupted sexual selection using an agent based model. 8th Biannual Meeting of the Australasian Evolution Society (AES) 2013, Geelong, Australia: Australasian Evolution Society.
Senior, A., Krkosek, M., Nakagawa, S. (2012). Could ecological feedback put the brakes on runaway-sexual-conflict induced evolutionary suicide. 14th International Society Behavioural Ecology Congress, Lund, Sweden.
Senior, A., Nakagawa, S. (2011). Induced sex-reversal in fish; an evolutionary perspective. 7th Biannual Meeting of the Australasian Evolution Society (AES) 2011, Townsville, Australia.

By Year

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2025

Ni, D., Senior, A., Raubenheimer, D., Simpson, S., Nanan, R. (2025). High-Fat and Low-Carbohydrate Dietary Environments Are Linked to Reduced Idiopathic Epilepsy Incidence and Prevalence. Annals of Clinical and Translational Neurology. [More Information]
Liu, R., Senior, A., Bao, Z., Koay, Y., Holmes, A., O'Sullivan, J. (2025). Multi-organ multi-omic and gut microbiome signatures of fat and sucrose dietary oversupply in cardiometabolic disease. iScience, 28(4), 111887. [More Information]

2024

Farris, K., Senior, A., Sobreira, D., Mitchell, R., Weber, Z., Ingerslev, L., Barrès, R., Simpson, S., Crean, A., Nobrega, M. (2024). Dietary macronutrient composition impacts gene regulation in adipose tissue. Communications Biology, 7(1). [More Information]
Ni, D., Senior, A., Raubenheimer, D., Simpson, S., Macia, L., Nanan, R. (2024). Global associations of macronutrient supply and asthma disease burden. European Journal of Immunology, 54(Suppl 1), 566-566. [More Information]
Ni, D., Senior, A., Raubenheimer, D., Simpson, S., Macia, L., Nanan, R. (2024). Global associations of macronutrient supply and asthma disease burden. Allergy, 79(7), 1989-1991. [More Information]
Ni, D., Tan, J., Reyes, J., Senior, A., Andrews, C., Taitz, J., Potier, C., Wishart, C., Spiteri, A., Piccio, L., King, N., Simpson, S., Nanan, R., Macia, L. (2024). High fat low carbohydrate is linked to protection against the development of CNS autoimmunity. European Journal of Immunology, 54(1), 230-230. [More Information]
Ni, D., Senior, A., Tan, J., Macia, L., Nanan, R. (2024). How nutritional landscapes impact food allergy. European Journal of Immunology, 54(Suppl 1), 567-567. [More Information]
Ni, D., Senior, A., Tan, J., Macia, L., Nanan, R. (2024). Linking Macronutrient Composition of Common Allergenic Foods to European and North American Food Allergy Prevalence. Clinical and Experimental Allergy. [More Information]
Crean, A., Pulpitel, T., Pini, T., Rickard, J., de Graaf, S., Senior, A., Simpson, S., Wali, J. (2024). Low-Fat, High-Carbohydrate Diets Reduce Body Weight and Sperm Count but Increase Sperm Motility in Mice. The Journal of Nutrition, 154(1), 60-68. [More Information]
Koemel, N., Laouali, N., Skilton, M., Shah, S., Senior, A., Severi, G., Mancini, F., Gill, T., Simpson, S., Raubenheimer, D., et al (2024). Macronutrient composition of plant-based diets and breast cancer risk: the E3N prospective cohort study. European Journal of Nutrition, 63(5), 1771-1781. [More Information]
Zaman, K., Mun, H., Solon-Biet, S., Senior, A., Raubenheimer, D., Simpson, S., Conigrave, A. (2024). Mice Regulate Dietary Amino Acid Balance and Energy Intake by Selecting between Complementary Protein Sources. The Journal of Nutrition, 154(6), 1766-1780. [More Information]
Ribeiro, R., Senior, A., Simpson, S., Tan, J., Raubenheimer, D., Le Couteur, D., Macia, L., Holmes, A., Eberhard, J., O'Sullivan, J., Koay, Y., Kanjrawi, A., Yang, J., Kim, T., Gosby, A. (2024). Rapid benefits in older age from transition to whole food diet regardless of protein source or fat to carbohydrate ratio: Arandomised control trial. Aging Cell, 23(11), e14276. [More Information]
Koemel, N., Laouali, N., Senior, A., Celermajer, D., Grech, A., Solon-Biet, S., Simpson, S., Raubenheimer, D., Gill, T., Skilton, M. (2024). The Relationship between Dietary Macronutrient Composition and Telomere Length Among US Adults. Advanced Biology, 8(4). [More Information]

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2023

Nakagawa, S., Noble, D., Lagisz, M., Spake, R., Viechtbauer, W., Senior, A. (2023). A robust and readily implementable method for the meta-analysis of response ratios with and without missing standard deviations. Ecology Letters, 26(2), 232-244. [More Information]
Wali, J., Ni, D., Facey, H., Dodgson, T., Pulpitel, T., Senior, A., Raubenheimer, D., Macia, L., Simpson, S. (2023). Determining the metabolic effects of dietary fat, sugars and fat-sugar interaction using nutritional geometry in a dietary challenge study with male mice. Nature Communications, 14(1). [More Information]
Das, S., Silver, R., Senior, A., Gilhooly, C., Bhapkar, M., Le Couteur, D. (2023). Diet composition, adherence to calorie restriction, and cardiometabolic disease risk modification. Aging Cell, 22(12), e14018. [More Information]
Koemel, N., Senior, A., Benmarhnia, T., Holmes, A., Okada, M., Oulhote, Y., Parker, H., Shah, S., Simpson, S., Raubenheimer, D., Gill, T., Skilton, M., et al (2023). Diet Quality, Microbial Lignan Metabolites, and Cardiometabolic Health among US Adults. Nutrients, 15(6). [More Information]
Senior, A. (2023). Estimating Genetic Variance in Life-Span Response to Diet: Insights From Statistical Simulation. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 78(3), 392-396. [More Information]
Saner, C., Senior, A., Zhang, H., Eloranta, A., Magnussen, C., Sabin, M., Juonala, M., Janner, M., Burgner, D., Schwab, U., Heitmann, B., Simpson, S., Raubenheimer, D., et al (2023). Evidence for protein leverage in a general population sample of children and adolescents. European Journal of Clinical Nutrition. [More Information]
Honfo, S., Senior, A., Legault, V., Presse, N., Turcot, V., Gaudreau, P., Simpson, S., Raubenheimer, D., Cohen, A. (2023). Evidence for protein leverage on total energy intake, but not body mass index, in a large cohort of older adults. International Journal of Obesity. [More Information]
Zhang, H., Senior, A., Saner, C., Olsen, N., Larsen, S., Simpson, S., Raubenheimer, D., Heitmann, B. (2023). Evidence for the protein leverage hypothesis in preschool children prone to obesity. Clinical Nutrition, 42(11), 2249-2257. [More Information]
Koemel, N., Senior, A., Celermajer, D., Grech, A., Gill, T., Simpson, S., Raubenheimer, D., Skilton, M. (2023). Multi-Nutrient Analysis of Dietary Macronutrients with All-Cause, Cardiovascular, and Cancer Mortality: Data from NHANES 1999–2014. Nutrients, 15(2). [More Information]
Lai, M., Li, A., Senior, A., Neely, G., Simpson, S., Wang, Q. (2023). Nutritional geometry framework of sleep. Life Sciences, 316. [More Information]
Nakagawa, S., Lagisz, M., O'Dea, R., Pottier, P., Rutkowska, J., Senior, A., Yang, Y., Noble, D. (2023). orchaRd 2.0: An R package for visualising meta-analyses with orchard plots. Methods in Ecology and Evolution, 14(8), 2003-2010. [More Information]
Solon-Biet, S., Clark, X., Bell-Anderson, K., Rusu, P., Perks, R., Freire, T., Pulpitel, T., Senior, A., Hoy, A., Aung, O., Le Couteur, D., Raubenheimer, D., Conigrave, A., Simpson, S., et al (2023). Toward reconciling the roles of FGF21 in protein appetite, sweet preference, and energy expenditure. Cell Reports, 42(12). [More Information]
Wang, T., Kroeger, C., Cassidy, S., Mitra, S., Ribeiro, R., Jose, S., Masedunskas, A., Senior, A., Fontana, L. (2023). Vegetarian Dietary Patterns and Cardiometabolic Risk in People With or at High Risk of Cardiovascular Disease: A Systematic Review and Meta-analysis. JAMA Network Open, 6(7), e2325658. [More Information]

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2022

Nakagawa, S., Senior, A., Viechtbauer, W., Noble, D. (2022). An assessment of statistical methods for non-independent data in ecological meta-analyses: Comment. Ecology, 103(1), 1-5. [More Information]
Raubenheimer, D., Senior, A., Mirth, C., Cui, Z., Hou, R., Le Couteur, D., Solon-Biet, S., Léopold, P., Simpson, S. (2022). An integrative approach to dietary balance across the life course. iScience, 25(5). [More Information]
Tan, J., Ni, D., Taitz, J., Pinget, G., Read, M., Senior, A., Wali, J., Elnour, R., Shanahan, E., Wu, H., Chadban, S., Nanan, R., King, N., Grau, G., Simpson, S., Macia, L. (2022). Dietary protein increases T-cell-independent sIgA production through changes in gut microbiota-derived extracellular vesicles. Nature Communications, 13(1), 4336-1-4336-15. [More Information]
Havula, E., Ghazanfar, S., Lamichane, N., Francis, D., Hasygar, K., Liu, Y., Alton, L., Johnstone, J., Needham, E., Pulpitel, T., Clark, T., Niranjan, H., Shang, V., Tong, V., Jiwnani, N., Audia, G., Neely, G., Yang, J., Simpson, S., Senior, A., et al (2022). Genetic variation of macronutrient tolerance in Drosophila melanogaster. Nature Communications, 13(1637), 1-16. [More Information]
Raynal, R., Noble, D., Riley, J., Senior, A., Warner, D., While, G., Schwanz, L. (2022). Impact of fluctuating developmental temperatures on phenotypic traits in reptiles: a meta-analysis. Journal of Experimental Biology, 225(1), jeb243369. [More Information]
Koemel, N., Senior, A., Dissanayake, H., Ross, J., McMullan, R., Kong, Y., Phang, M., Hyett, J., Raubenheimer, D., Gordon, A., Simpson, S., Skilton, M. (2022). Maternal dietary fatty acid composition and newborn epigenetic aging-a geometric framework approach. American Journal of Clinical Nutrition, 115(1), 118-127. [More Information]
Solon-Biet, S., Griffiths, L., Fosh, S., Le Couteur, D., Simpson, S., Senior, A. (2022). Meta-analysis links dietary branched-chain amino acids to metabolic health in rodents. BMC Biology, 20(1), 19. [More Information]
Senior, A., Legault, V., Lavoie, F., Presse, N., Gaudreau, P., Turcot, V., Raubenheimer, D., Le Couteur, D., Simpson, S., Cohen, A. (2022). Multidimensional associations between nutrient intake and healthy ageing in humans. BMC Biology, 20(1), Article 196-17 pages. [More Information]
Clark, T., Crean, A., Senior, A. (2022). Obesogenic diets induce anxiety in rodents: a systematic review and meta-analysis. Obesity Reviews, 23(3), 1-7. [More Information]
Campbell, G., Lucic-Fisher, S., Brandon, A., Senior, A., Bell-Anderson, K. (2022). Sex-specific effects of maternal dietary carbohydrate quality on fetal development and offspring metabolic phenotype in mice. Frontiers in Nutrition, 9. [More Information]
Nelson, M., Madsen, S., Cooke, K., Fritzen, A., Thorius, I., Masson, S., carroll, L., Weiss, F., Seldin, M., Potter, M., Hocking, S., Fazakerley, D., Brandon, A., Thillainadesan, S., Senior, A., Cooney, G., Stoeckli, J., James, D. (2022). Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance. Cell Metabolism, 34(2), 227-239.e6. [More Information]
Senior, A., Raubenheimer, D., Simpson, S. (2022). Testing the protein-leveragehypothesis using population surveillance data. Royal Society Open Science, 9, 220756-1-220756-15. [More Information]

show 9 more

2021

Wali, J., Raubenheimer, D., Senior, A., Le Couteur, D., Simpson, S. (2021). Cardio-metabolic consequences of dietary carbohydrates: reconciling contradictions using nutritional geometry. Cardiovascular Research, 117(2), 386-401. [More Information]
Tan, J., Ni, D., Wali, J., Cox, D., Pinget, G., Taitz, J., Daien, C., Senior, A., Read, M., Simpson, S., King, N., Macia, L. (2021). Dietary carbohydrate, particularly glucose, drives B cell lymphopoiesis and function. iScience, 24(8), 102835. [More Information]
Francis, D., Ghazanfar, S., Havula, E., Krycer, J., Strbenac, D., Senior, A., Minard, A., Geddes, T., Nelson, M., Weiss, F., Stoeckli, J., Yang, J., James, D. (2021). Genome-wide analysis in Drosophila reveals diet-by-gene interactions and uncovers diet-responsive genes. G3: Genes, Genomes, Genetics, 11(10), jkab171. [More Information]
Noble, D., Senior, A., Uller, T., Schwanz, L. (2021). Heightened among-individual variation in life history but not morphology is related to developmental temperature in reptiles. Journal of Evolutionary Biology, 34(11), 1793-1802. [More Information]
Wali, J., Milner, A., Luk, A., Pulpitel, T., Dodgson, T., Facey, H., Wahl, D., Kebede, M., Senior, A., Sullivan, M., Brandon, A., Yau, B., Lockwood, G., Koay, Y., Ribeiro, R., Solon-Biet, S., Bell-Anderson, K., O'Sullivan, J., Macia, L., Cooney, G., Cogger, V., Holmes, A., Raubenheimer, D., Le Couteur, D., Simpson, S., et al (2021). Impact of dietary carbohydrate type and protein–carbohydrate interaction on metabolic health. Nature Metabolism, 3(6), 810-828. [More Information]
Usui, T., Macleod, M., McCann, S., Senior, A., Nakagawa, S. (2021). Meta-analysis of variation suggests that embracing variability improves both replicability and generalizability in preclinical research. PLoS Biology, 19(5), e3001009. [More Information]
Le Couteur, D., Solon-Biet, S., Parker, B., Pulpitel, T., Brandon, A., Hunt, N., Wali, J., Gokarn, R., Senior, A., Cooney, G., Raubenheimer, D., James, D., Simpson, S., et al (2021). Nutritional reprogramming of mouse liver proteome is dampened by metformin, resveratrol, and rapamycin. Cell Metabolism, 33(12), 2367-2379.e4. [More Information]
Norris, D., Yang, P., Shin, S., Kearney, A., Kim, H., Geddes, T., Senior, A., Fazakerley, D., Nguyen, L., James, D., Burchfield, J. (2021). Signaling Heterogeneity is Defined by Pathway Architecture and Intercellular Variability in Protein Expression. iScience, 24(2), 102118. [More Information]
Koemel, N., Senior, A., Dissanayake, H., Raubenheimer, D., Simpson, S., Skilton, M. (2021). THE IMPACT OF MATERNAL DIETARY FATTY ACIDS ON NEWBORN CARDIOMETABOLIC RISK. Journal of the American College of Cardiology, 77(18), 1479. [More Information]
Nakagawa, S., Lagisz, M., O'Dea, R., Rutkowska, J., Yang, Y., Noble, D., Senior, A. (2021). The orchard plot: Cultivating a forest plot for use in ecology, evolution, and beyond. Research Synthesis Methods, 12(1), 4-12. [More Information]

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2020

Myers, J., Senior, A., Zadmajid, V., Sørensen, S., Butts, I. (2020). Associations between Ovarian Fluid and Sperm Swimming Trajectories in Marine and Freshwater Teleosts: A Meta-Analysis. Reviews in Fisheries Science & Aquaculture, 28(3), 322-339. [More Information]
Le Couteur, D., Ribeiro, R., Senior, A., Hsu, B., Hirani, V., Blyth, F., Waite, L., Simpson, S., Naganathan, V., Cumming, R., et al (2020). Branched Chain Amino Acids, Cardiometabolic Risk Factors and Outcomes in Older Men: The Concord Health and Ageing in Men Project. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(10), 1805-1810. [More Information]
Yue, K., Jarvie, S., Senior, A., Van Meerbeek, K., Peng, Y., Ni, X., Wu, F., Svenning, J. (2020). Changes in plant diversity and its relationship with productivity in response to nitrogen addition, warming and increased rainfall. Oikos, 129(7), 939-952. [More Information]
Rodriguez Paris, V., Solon-Biet, S., Senior, A., Edwards, M., Desai, R., Tedla, N., Cox, M., Ledger, W., Gilchrist, R., Simpson, S., Handelsman, D., Walters, K. (2020). Defining the impact of dietary macronutrient balance on PCOS traits. Nature Communications, 11(1), 5262. [More Information]
Saner, C., Tassoni, D., Harcourt, B., Kao, K., Alexander, E., McCallum, Z., Olds, T., Rowlands, A., Burgner, D., Simpson, S., Raubenheimer, D., Senior, A., et al (2020). Evidence for Protein Leverage in Children and Adolescents with Obesity. Obesity, 28(4), 822-829. [More Information]
Senior, A., Nakagawa, S., Raubenheimer, D., Simpson, S. (2020). Global associations between macronutrient supply and age-specific mortality. Proceedings of the National Academy of Sciences of the United States of America, 117(48), 30824-30835. [More Information]
Cohen, A., Kennedy, B., Anglas, U., Bronikowski, A., Deelen, J., Dufour, F., Ferbeyre, G., Ferrucci, L., Franceschi, C., Frasca, D., Senior, A., et al (2020). Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mechanisms of Ageing and Development, 191, 111316. [More Information]
Xu, X., Solon-Biet, S., Senior, A., Raubenheimer, D., Simpson, S., Fontana, L., Mueller, S., Yang, J. (2020). LC-N2G: a local consistency approach for nutrigenomics data analysis. BMC Bioinformatics, 21(1), 530. [More Information]
Genoud, S., Senior, A., Hare, D., Double, K. (2020). Meta-Analysis of Copper and Iron in Parkinson's Disease Brain and Biofluids. Movement Disorders, 35(4), 662-671. [More Information]
Senior, A., Viechtbauer, W., Nakagawa, S. (2020). Revisiting and expanding the meta-analysis of variation: The log coefficient of variation ratio. Research Synthesis Methods, 11(4), 553-567. [More Information]
Freire, T., Senior, A., Perks, R., Pulpitel, T., Clark, X., Brandon, A., Wahl, D., Hatchwell, L., Le Couteur, D., Cooney, G., Larance, M., Simpson, S., Solon-Biet, S. (2020). Sex-specific metabolic responses to 6 hours of fasting during the active phase in young mice. Journal of Physiology, 598(11), 2081-2092. [More Information]
Zajitschek, S., Zajitschek, F., Bonduriansky, R., Brooks, R., Cornwell, W., Falster, D., Lagisz, M., Mason, J., Senior, A., Noble, D., et al (2020). Sexual dimorphism in trait variability and its eco-evolutionary and statistical implications. eLife, 9, 1-17. [More Information]
Pawelec, G., Bronikowski, A., Cunnane, S., Ferrucci, L., Franceschi, C., Fülöp, T., Gaudreau, P., Gladyshev, V., Gonos, E., Gorbunova, V., Senior, A., et al (2020). The conundrum of human immune system “senescence”. Mechanisms of Ageing and Development, 192, 1-8. [More Information]

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2019

Solon-Biet, S., Cogger, V., Pulpitel, T., Wahl, D., Clark, X., Bagley, E., Gregoriou, G., Senior, A., Wang, Q., Brandon, A., Perks, R., O'Sullivan, J., Koay, Y., Bell-Anderson, K., Kebede, M., Yau, B., Atkinson, C., Dodgson, T., Wali, J., Raubenheimer, D., Cooney, G., Le Couteur, D., Simpson, S., et al (2019). Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control. Nature Metabolism, 1(5), 532-545. [More Information]
Senior, A., Solon-Biet, S., Cogger, V., Le Couteur, D., Nakagawa, S., Raubenheimer, D., Simpson, S. (2019). Dietary macronutrient content, age-specific mortality and lifespan. Proceedings of the Royal Society B: Biological Sciences, 286(1902), 1-9. [More Information]
Gwynn, J., Sim, K., Searle, T., Senior, A., Lee, A., Brimblecombe, J. (2019). Effect of nutrition interventions on diet-related and health outcomes of Aboriginal and Torres Strait Islander Australians: a systematic review. BMJ Open, 9(4), 1-15. [More Information]
Nie, Y., Wei, F., Zhou, W., Hu, Y., Senior, A., Wu, Q., Yan, L., Raubenheimer, D. (2019). Giant pandas are macronutritional carnivores. Current Biology, 29(10), 1677-1682.e2. [More Information]
Crean, A., Senior, A. (2019). High-fat diets reduce male reproductive success in animal models: A systematic review and meta-analysis. Obesity Reviews, 20(6), 921-933. [More Information]
Hosking, C., Raubenheimer, D., Charleston, M., Simpson, S., Senior, A. (2019). Macronutrient intakes and the lifespan-fecundity trade-off: a geometric framework agent-based model. Journal of the Royal Society Interface, 16(151), 1-13. [More Information]
Ribeiro, R., Solon-Biet, S., Pulpitel, T., Senior, A., Cogger, V., Clark, X., O'Sullivan, J., Koay, Y., Hirani, V., Blyth, F., Seibel, M., Naganathan, V., Cumming, R., Handelsman, D., Simpson, S., Le Couteur, D., et al (2019). Of older mice and men: Branched-chain amino acids and body composition. Nutrients, 11(8), 1-11. [More Information]
Thieltges, D., Goedknegt, M., O'Dwyer, K., Senior, A., Kamiya, T. (2019). Parasites and stable isotopes: a comparative analysis of isotopic discrimination in parasitic trophic interactions. Oikos, 128(9), 1329-1339. [More Information]
Morimoto, J., Senior, A., Ruiz, K., Wali, J., Pulpitel, T., Solon-Biet, S., Cogger, V., Raubenheimer, D., Le Couteur, D., Simpson, S., Eberhard, J. (2019). Sucrose and starch intake contribute to reduced alveolar bone height in a rodent model of naturally occurring periodontitis. PloS One, 14(3), 1-10. [More Information]

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2018

Mijatovic, J., Capling, A., Cheng, S., Stamatakis, E., Louie, J., Cheung, N., Markovic, T., Ross, G., Senior, A., Brand-Miller, J., Flood, V. (2018). Associations of diet and physical activity with risk for gestational diabetes mellitus: A Systematic review and meta-analysis. Nutrients, 10(6). [More Information]
Wahl, D., Solon-Biet, S., Wang, K., Wali, J., Pulpitel, T., Clark, X., Raubenheimer, D., Senior, A., Sinclair, D., Cooney, G., Cogger, V., Simpson, S., Le Couteur, D., et al (2018). Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Reports, 25(8), 2234-2243.e6. [More Information]
Grueber, C., Gray, L., Morris, K., Simpson, S., Senior, A. (2018). Intergenerational effects of nutrition on immunity: a systematic review and meta-analysis. Biological Reviews, 93(2), 1108-1124. [More Information]
Ngo, T., Senior, A., Culina, A., Santos, E., Vlak, J., Zwart, M. (2018). Quantitative analysis of the dose–response of white spot syndrome virus in shrimp. Journal of Fish Diseases, 41(11), 1733-1744. [More Information]
Machovsky-Capuska, G., Miller, M., Silva, F., Amiot, C., Stockin, K., Senior, A., Schuckard, R., Melville, D., Raubenheimer, D. (2018). The nutritional nexus: Linking niche, habitat variability and prey composition in a generalist marine predator. Journal of Animal Ecology, 87(5), 1286-1298. [More Information]

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2017

Lihoreau, M., Charleston, M., Senior, A., Clissold, F., Raubenheimer, D., Simpson, S., Buhl, J. (2017). Collective foraging in spatially complex nutritional environments. Philosophical Transactions of the Royal Society B: Biological Sciences, 372(1727), Art. 20160238-1-Art. 20160238-11. [More Information]
Ribeiro, R., Hirani, V., Senior, A., Gosby, A., Cumming, R., Blyth, F., Naganathan, V., Waite, L., Handelsman, D., Kendig, H., Seibel, M., Simpson, S., Stanaway, F., Allman-Farinelli, M., Le Couteur, D. (2017). Diet quality and its implications on the cardio-metabolic, physical and general health of older men: the Concord Health and Ageing in Men Project (CHAMP). British Journal of Nutrition, 118, 130-143. [More Information]
Senior, A., Nakagawa, S., Raubenheimer, D., Simpson, S., Noble, D. (2017). Dietary restriction increases variability in longevity. Biology Letters, 13(3), 1-4. [More Information]
Wong, A., Wang, Q., Morimoto, J., Senior, A., Lihoreau, M., Neely, G., Simpson, S., Ponton, F. (2017). Gut Microbiota Modifies Olfactory-Guided Microbial Preferences and Foraging Decisions in Drosophila. Current Biology, 27(15), 2397-2404. [More Information]
Coogan, S., Machovsky-Capuska, G., Senior, A., Martin, J., Major, R., Raubenheimer, D. (2017). Macronutrient selection of free-ranging urban Australian white ibis (Threskiornis moluccus). Behavioural Ecology, 28(4), 1021-1029. [More Information]
Nakagawa, S., Noble, D., Senior, A., Lagisz, M. (2017). Meta-evaluation of meta-analysis: Ten appraisal questions for biologists. BMC Biology, 15(1), 1-14. [More Information]
Campbell, G., Senior, A., Bell-Anderson, K. (2017). Metabolic Effects of High Glycaemic Index Diets: A Systematic Review and Meta-Analysis of Feeding Studies in Mice and Rats. Nutrients, 9(7), 1-20. [More Information]

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2016

Senior, A., Lihoreau, M., Charleston, M., Buhl, J., Raubenheimer, D., Simpson, S. (2016). Adaptive collective foraging in groups with conflicting nutritional needs. Royal Society Open Science, 3(4), 1-15. [More Information]
Senior, A., Lim, J., Adolfsson, S., Lamatsch, D., Nagakawa, S. (2016). Condition and reproductive investment in the western mosquitofish (Gambusia affinis): little evidence for condition-dependent sex-biased investment. Biological Journal of the Linnean Society, 119(2), 430-435. [More Information]
Cogger, V., Mohamad, M., Solon-Biet, S., Senior, A., Warren, A., O'Reilly, J., Tung, B., Svistounov, D., McMahon, A., Fraser, R., Raubenheimer, D., Holmes, A., Simpson, S., Le Couteur, D. (2016). Dietary Macronutrients and the Aging Liver Sinusoidal Endothelial Cell. American Journal of Physiology - Heart and Circulatory Physiology, 310(9), H1064-H1070. [More Information]
Machovsky-Capuska, G., Senior, A., Zantis, S., Barna, K., Cowieson, A., Panyda, S., Pavard, C., Shiels, M., Raubenheimer, D. (2016). Dietary protein selection in a free-ranging urban population of common myna birds. Behavioral Ecology, 27(1), 219-227. [More Information]
Besson, A., Lagisz, M., Senior, A., Hector, K., Nagakawa, S. (2016). Effect of maternal diet on offspring coping styles in rodents: a systematic review and meta-analysis. Biological Reviews, 91(4), 1065-1080. [More Information]
Vanderpham, J., Nakagawa, S., Senior, A., Closs, G. (2016). Habitat-related specialization of lateral-line system morphology in a habitat-generalist and a habitat-specialist New Zealand eleotrid. Journal of Fish Biology, 88(4), 1631-1641. [More Information]
Senior, A., Grueber, C., Kamiya, T., Lagisz, M., O'Dwyer, K., Santos, E., Nakagawa, S. (2016). Heterogeneity in ecological and evolutionary meta-analyses: its magnitude and implications. Ecology, 97(12), 3293-3299. [More Information]
Jones, P., Senior, A., Allibone, R., Closs, G. (2016). Life-history variation in a species complex of nonmigratory galaxiids. Ecology of Freshwater Fish, 25(2), 174-189. [More Information]
Senior, A., Grueber, C., Machovsky-Capuska, G., Simpson, S., Raubenheimer, D. (2016). Macronutritional consequences of food generalism in an invasive mammal, the wild boar. Mammalian Biology, 81(5), 523-526. [More Information]
Senior, A., Gosby, A., Lu, J., Simpson, S., Raubenheimer, D. (2016). Meta-analysis of variation: an illustration comparing the effects of two dietary interventions on variability in weight. Evolution, Medicine and Public Health, 2016 (1), 244-255. [More Information]
Geoghegan, J., Senior, A., Holmes, E. (2016). Pathogen population bottlenecks and adaptive landscapes: overcoming the barriers to disease emergence. Proceedings of the Royal Society B: Biological Sciences, 283(1837), 1-9. [More Information]
Machovsky-Capuska, G., Senior, A., Benn, E., Tait, A., Schuckard, R., Stockin, K., Cook, W., Ogle, M., Barna, K., Melville, D., Wright, B., Raubenheimer, D., et al (2016). Sex-specific macronutrient foraging strategies in a highly successful marine predator: the Australasian gannet. Marine Biology, 163(4), 1-14. [More Information]
Senior, A., Lihoreau, M., Buhl, J., Raubenheimer, D., Simpson, S. (2016). Social Network Analysis and Nutritional An Integrated Modelling Approach. Frontiers in Psychology, 7, 1-10. [More Information]
Senior, A., Johnson, S., Nakagawa, S. (2016). Sperm traits of masculinized fish relative to wild-type males: a systematic review and meta-analyses. Fish and Fisheries, 17(1), 143-164. [More Information]
Le Couteur, D., Solon-Biet, S., Cogger, V., Mitchell, S., Senior, A., de Cabo, R., Raubenheimer, D., Simpson, S. (2016). The impact of low-protein high-carbohydrate diets on aging and lifespan. Cellular and Molecular Life Sciences, 73(6), 1237-1252. [More Information]
Machovsky-Capuska, G., Senior, A., Simpson, S., Raubenheimer, D. (2016). The Multidimensional Nutritional Niche. Trends in Ecology and Evolution, 31(5), 355-365. [More Information]
Geoghegan, J., Senior, A., Di Giallonardo, F., Holmes, E. (2016). Virological factors that increase the transmissibility of emerging human viruses. Proceedings of the National Academy of Sciences of the United States of America, 113(15), 4170-4175. [More Information]

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2015

Lamatsch, D., Adolfsson, S., Senior, A., Christiansen, G., Pichler, M., Ozaki, Y., Smeds, L., Schartl, M., Nakagawa, S. (2015). A Transcriptome Derived Female-Specific Marker from the Invasive Western Mosquitofish (Gambusia affinis). PloS One, 10(2), 1-16. [More Information]
Senior, A., Nakagawa, S., Lihoreau, M., Simpson, S., Raubenheimer, D. (2015). An Overlooked Consequence of Dietary Mixing: A Varied Diet Reduces Interindividual Variance in Fitness. The American Naturalist, 186(5), 649-659. [More Information]
Jarvie, S., Senior, A., Adolph, S., Seddon, P., Cree, A. (2015). Captive rearing affects growth but not survival in translocated juvenile tuatara. Journal of Zoology, 297(3), 184-193. [More Information]
Senior, A., Lokman, P., Gloss, G., Nakagawa, S. (2015). Ecological and evolutionary applications for environmental sex reversal of fish. The Quarterly Review of Biology, 90(1), 23-44. [More Information]
Senior, A., Charleston, M., Lihoreau, M., Buhl, J., Raubenheimer, D., Simpson, S. (2015). Evolving nutritional strategies in the presence of competition: A geometric agent-based model. PLoS Computational Biology, 11(3), 1-24. [More Information]
Nakagawa, S., Poulin, R., Mengersen, K., Reinhold, K., Engqvist, L., Lagisz, M., Senior, A. (2015). Meta-analysis of variation: Ecological and evolutionary applications and beyond. Methods in Ecology and Evolution, 6, 143-152. [More Information]
Grueber, C., Knafler, G., King, T., Senior, A., Grosser, S., Robertson, B., Weston, K., Brekke, P., Harris, C., Jamieson, I. (2015). Toll-like receptor diversity in 10 threatened bird species: relationship with microsatellite heterozygosity. Conservation Genetics, 16, 595-611. [More Information]

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2014

Kamiya, T., O'Dwyer, K., Westerdahl, H., Senior, A., Nakagawa, S. (2014). A quantitative review of MHC-based mating preference: the role of diversity and dissimilarity. Molecular Ecology, 23(21), 5151-5163. [More Information]
Schadewinkel, R., Senior, A., Wilson, D., Jamieson, I. (2014). Effects on South Island robins (Petroica australis) from pest control using aerially applied 1080 poison. New Zealand Journal of Ecology, 38(2), 315-321.
Lim, J., Senior, A., Nakagawa, S. (2014). Heterogeneity in individual quality and reproductive trade-offs within species. Evolution, 68(8), 2306-2318. [More Information]
Senior, A., Nakagawa, S., Grimm, V. (2014). The Evolutionary Consequences of Disrupted Male Mating Signals: An Agent-Based Modelling Exploration of Endocrine Disrupting Chemicals in the Guppy. PloS One, 9(7), 1-9. [More Information]

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2013

Senior, A., Nakagawa, S. (2013). A comparative analysis of chemically induced sex reversal in teleosts: challenging conventional suppositions. Fish and Fisheries, 14(1), 60-76. [More Information]
Senior, A., Nakagawa, S., Grimm, V. (2013). Exploring the Evolutionary Consequences of chemically disrupted sexual selection using an agent based model. 8th Biannual Meeting of the Australasian Evolution Society (AES) 2013, Geelong, Australia: Australasian Evolution Society.
Senior, A., Krkosek, M., Nakagawa, S. (2013). The practicality of Trojan sex chromosomes as a biological control: an agent based model of two highly invasive Gambusia species. Biological Invasions, 15(8), 1765-1782. [More Information]

2012

Senior, A., Krkosek, M., Nakagawa, S. (2012). Could ecological feedback put the brakes on runaway-sexual-conflict induced evolutionary suicide. 14th International Society Behavioural Ecology Congress, Lund, Sweden.
Senior, A., Nat Lim, J., Nakagawa, S. (2012). The fitness consequences of environmental sex reversal in fish: a quantitative review. Biological Reviews, 87(4), 900-911. [More Information]

2011

Senior, A., Nakagawa, S. (2011). Induced sex-reversal in fish; an evolutionary perspective. 7th Biannual Meeting of the Australasian Evolution Society (AES) 2011, Townsville, Australia.

Selected Grants

2025

Stoichiometric flexibility shapes microbial function and community assembly, Warren C, Holmes A, Senior A, Australian Research Council (ARC)/Discovery Projects (DP)

2024

Unlocking the potential for healthy ageing by modulating protein kinase C epsilon, Ashe A, Senior A, School of Life and Environmental Sciences (SOLES)/Strategic Partnership Seeding Grant
A Varied Diet, Ageing, and the Evolution of Life Histories, Senior A, Australian Research Council (ARC)/Future Fellowships (FT)

2019

Self-selected diet composition, adherence to caloric restriction and cardiometabolic disease risk, Le Couteur D, Senior A, National Institutes of Health (USA)/Research Support

2018

Diet, Variance and Individual Variability in Life-History, Senior A, Australian Research Council (ARC)/Discovery Early Career Researcher Award (DECRA)

Faculty of Science

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