Associate Professor Timothy Newsome
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Associate Professor Timothy Newsome

Associate Professor
School of Life and Environmental Sciences
Phone
+61 2 9351 2907
Fax
+61 2 9351 4571
Associate Professor Timothy Newsome

Dr Tim Newsome was appointed Lecturer in the School of Molecular Bioscience in 2007, with key leadership responsibilities in the areas of virology research and teaching. He was made Senior Lecturer in 2012 and Associate Professor in 2019.

Dr Newsome was awarded his PhD from the University of Zurich in 2000, and moved to Cancer Research UK, London shortly after to work as a Post-doc, successfully managing to publish his work in the highest international journals, and developing novel strategies in advanced light microscopy, genetic manilpulation of vial genomes, and tandem affinity approach for the purification of protein complezes to address new questions in host/pathogen interactions using vaccinia virus. In 2008 Tim was awarded the Selby Research Award, and later was the recipient of the Faculty of Science Citations for Excellence in Teaching award, recognising his contribution to enhancing the student learning environment by innovations to the online delivery of courses, integrating imaging into the undergraduate syllabus via a successful TIES application, and good practise in teaching.

Infection and Immunological Conditions;

Vaccines and vaccinology; Virus diseases; Virology

Infection and Immunological Conditions, Genetics and genomics, Microbiology, Molecular biology and biotechnology
Project titleResearch student
Role of TGF-β pathway and SMAD signalling in viral infection and COVID-19Nicholas Peter GRACIE

Publications

Book Chapters

  • Marzook, N., Newsome, T. (2017). Viruses That Exploit Actin-Based Motility for Their Replication and Spread. In Brigitte M. Jockusch (Eds.), The Actin Cytoskeleton, (pp. 237-261). Cham: Springer International Publishing. [More Information]
  • Newsome, T., Marty, A., Lynn, H., Procter, D. (2011). Navigating the subcellular space: Lessons from vaccinia virus. In Russell J Diefenbach and Anthony L Cunningham (Eds.), Viral Transport, Assembly and Egress, (pp. 155-177). Kerala, India: Research Signpost.

Journals

  • Gracie, N., Lai, L., Newsome, T. (2024). Cellular signalling by SARS-CoV-2 spike protein. Microbiology Australia, 45(1), 13-17. [More Information]
  • Howell, L., Gracie, N., Newsome, T. (2024). Single-cell analysis of VACV infection reveals pathogen-driven timing of early and late phases and host-limited dynamics of virus production. PLoS Pathogens, 20(8), e1012423. [More Information]
  • Xu, A., Basant, A., Schleich, S., Newsome, T., Way, M. (2023). Kinesin-1 transports morphologically distinct intracellular virions during vaccinia infection. Journal of Cell Science, 136(5). [More Information]

2024

  • Gracie, N., Lai, L., Newsome, T. (2024). Cellular signalling by SARS-CoV-2 spike protein. Microbiology Australia, 45(1), 13-17. [More Information]
  • Howell, L., Gracie, N., Newsome, T. (2024). Single-cell analysis of VACV infection reveals pathogen-driven timing of early and late phases and host-limited dynamics of virus production. PLoS Pathogens, 20(8), e1012423. [More Information]

2023

  • Xu, A., Basant, A., Schleich, S., Newsome, T., Way, M. (2023). Kinesin-1 transports morphologically distinct intracellular virions during vaccinia infection. Journal of Cell Science, 136(5). [More Information]
  • Speck, P., Mackenzie, J., Bull, R., Slobedman, B., Abendroth, A., Harman, A., Tu, T., Ashley, C., Petrone, M., Samer, C., Cunningham, A., Mahar, J., Newsome, T., Nasr, N., et al (2023). Statement in Support of: "Virology under the Microscope - a Call for Rational Discourse". mSphere, 8(3). [More Information]
  • Speck, P., Mackenzie, J., Bull, R., Slobedman, B., Abendroth, A., Harman, A., Tu, T., Ashley, C., Petrone, M., Samer, C., Cunningham, A., Mahar, J., Newsome, T., Nasr, N., et al (2023). Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”. Journal of Virology, 97(5). [More Information]

2022

  • Lai, L., Gracie, N., Gowripalan, A., Howell, L., Newsome, T. (2022). SMAD proteins: Mediators of diverse outcomes during infection. European Journal of Cell Biology, 101(2). [More Information]

2021

  • Denes, C., Newsome, T., Miranda Saksena, M., Cunningham, A., Diefenbach, R. (2021). A putative WAVE regulatory complex (WRC) interacting receptor sequence (WIRS) in the cytoplasmic tail of HSV-1 gE does not function in WRC recruitment or neuronal transport. Access Microbiology, 3(3), 206. [More Information]
  • Abbott, C., Newsome, T. (2021). A tight squeeze: host control of Listeria invasion. Developmental Cell, 56(4), 404-405. [More Information]

2020

  • Gowripalan, A., Abbott, C., McKenzie, C., Chan, W., Karupiah, G., Levy, L., Newsome, T. (2020). Cell-to-cell spread of vaccinia virus is promoted by TGF-β-independent Smad4 signalling. Cellular Microbiology, 22(8), e13206. [More Information]
  • Kels, M., Ng, E., Al Rumaih, Z., Pandey, P., Ruuls, S., Korner, H., Newsome, T., Chaudhri, G., Karupiah, G. (2020). TNF deficiency dysregulates inflammatory cytokine production, leading to lung pathology and death during respiratory poxvirus infection. Proceedings of the National Academy of Sciences of the United States of America, 117(27), 15935-15946. [More Information]

2019

  • Eldi, P., Chaudhri, G., Nutt, S., Newsome, T., Karupiah, G. (2019). Viral Replicative Capacity, Antigen Availability via Hematogenous Spread, and High TFH:TFR Ratios Drive Induction of Potent Neutralizing Antibody Responses. Journal of Virology, 93(6), 1-17. [More Information]

2018

  • Duncan, M., Horsington, J., Eldi, P., Al Rumaih, Z., Karupiah, G., Newsome, T. (2018). Loss of actin-based motility impairs ectromelia virus release in vitro but is not critical to spread in vivo. Viruses, 10(3), 1-14. [More Information]
  • Lynn, H., Howell, L., Diefenbach, R., Newsome, T. (2018). Phototracking Vaccinia Virus Transport Reveals Dynamics of Cytoplasmic Dispersal and a Requirement for A36R and F12L for Exit from the Site of Wrapping. Viruses, 10(8), 1-18. [More Information]

2017

  • Marzook, N., Latham, S., Lynn, H., McKenzie, C., Chaponnier, C., Grau, G., Newsome, T. (2017). Divergent roles of beta- and gamma-actin isoforms during spread of vaccinia virus. Cytoskeleton, 74(4), 170-183. [More Information]
  • Marzook, N., Newsome, T. (2017). Viruses That Exploit Actin-Based Motility for Their Replication and Spread. In Brigitte M. Jockusch (Eds.), The Actin Cytoskeleton, (pp. 237-261). Cham: Springer International Publishing. [More Information]

2015

  • Sakala, I., Chaudhri, G., Scalzo, A., Eldi, P., Newsome, T., Buller, R., Karupiah, G. (2015). Evidence for Persistence of Ectromelia Virus in Inbred Mice, Recrudescence Following Immunosuppression and Transmission to Naïve Mice. PLoS Pathogens, 11(12), 1-26. [More Information]
  • Newsome, T., Marzook, N. (2015). Viruses that ride on the coat-tails of actin nucleation. Seminars in Cell and Developmental Biology, 46, 155-163. [More Information]

2014

  • Marzook, N., Procter, D., Lynn, H., Yamamoto, Y., Horsington, J., Newsome, T. (2014). Methodology for the Efficient Generation of Fluorescently Tagged Vaccinia Virus Proteins. Journal of Visualized Experiments, 83, 1-10. [More Information]
  • Dobson, B., Procter, D., Hollett, N., Flesch, I., Newsome, T., Tscharke, D. (2014). Vaccinia virus F5 is required for normal plaque morphology in multiple cell lines but not replication in culture or virulence in mice. Virology, 456-457(145), 145-156. [More Information]

2013

  • Horsington, J., Lynn, H., Turnbull, L., Cheng, D., Braet, F., Diefenbach, R., Whitchurch, C., Karupiah, G., Newsome, T. (2013). A36-dependent Actin Filament Nucleation Promotes Release of Vaccinia Virus. PLoS Pathogens, 9(3), 1-15. [More Information]

2012

  • Lynn, H., Horsington, J., Ter, L., Han, S., Chew, Y., Diefenbach, R., Way, M., Chaudhri, G., Karupiah, G., Newsome, T. (2012). Loss of Cytoskeletal Transport during Egress Critically Attenuates Ectromelia Virus Infection In Vivo. Journal of Virology, 86(13), 7427-7443. [More Information]
  • Aggarwal, A., Iemma, T., Shih, I., Newsome, T., McAllery, S., Cunningham, A., Turville, S. (2012). Mobilization of HIV Spread by Diaphanous 2 Dependent Filopodia in Infected Dendritic Cells. PLoS Pathogens, 8(6), 1-20. [More Information]
  • Horsington, J., Turnbull, L., Whitchurch, C., Newsome, T. (2012). Sub-viral imaging of vaccinia virus using super-resolution microscopy. Journal of Virological Methods, 186(1-2), 132-136. [More Information]

2011

  • Newsome, T., Marty, A., Lynn, H., Procter, D. (2011). Navigating the subcellular space: Lessons from vaccinia virus. In Russell J Diefenbach and Anthony L Cunningham (Eds.), Viral Transport, Assembly and Egress, (pp. 155-177). Kerala, India: Research Signpost.

2009

  • Dodding, M., Newsome, T., Collinson, L., Edwards, C., Way, M. (2009). An E2-F12 complex is required for intracellular enveloped virus morphogenesis during vaccinia infection. Cellular Microbiology, 11(5), 808-824. [More Information]
  • Stelzer-Braid, S., Oliver, B., Blazey, A., Argent, E., Newsome, T., Rawlinson, W., Tovey, E. (2009). Exhalation of respiratory viruses by breathing, coughing, and talking. Journal of Medical Virology, 81(9), 1674-1679. [More Information]
  • Weisswange, I., Newsome, T., Schleich, S., Way, M. (2009). The rate of N-WASP exchange limits the extent of ARP2/3-complex-dependent actin-based motility. Nature, 458(5), 87-91. [More Information]

2008

  • Berger, J., Senti, K., Senti, G., Newsome, T., Asling, B., Dickson, B., Suzuki, T. (2008). Systematic Identification of Genes that Regulate Neuronal Wiring in the Drosophila Visual System. PLoS Genetics, 4(5), e1000085-1-e1000085-14. [More Information]

2007

  • Bracale, A., Cesca, F., Neubrand, V., Newsome, T., Way, M., Schiavo, G. (2007). Kidins220/ARMS Is Transported by a Kinesin-1-based Mechanism Likely to be Involved in Neuronal Differentiation. Molecular Biology of the Cell, 18(1), 142-152. [More Information]
  • Arakawa, Y., Cordeiro, J., Schleich, S., Newsome, T., Way, M. (2007). The release of vaccinia virus from infected cells requires RhoA-mDia modulation of cortical actin. Cell Host and Microbe, 1(3), 227-240. [More Information]

2006

  • Newsome, T., Weisswange, I., Frischknecht, F., Way, M. (2006). Abl collaborates with Src family kinases to stimulate actin-based motility of vaccinia virus. Cellular Microbiology, 8(2), 233-241. [More Information]

2004

  • Newsome, T., Scaplehorn, N., Way, M. (2004). Src Mediates a Switch from Microtubule- to Actin-Based Motility of Vaccinia Virus. Science, 306(5693), 124-129. [More Information]

2003

  • Grosse, R., Copeland, J., Newsome, T., Way, M., Treisman, R. (2003). A role for VASP in RhoA-Diaphanous signalling to actin dynamics and SRF activity. EMBO Journal, 22(12), 3050-3061. [More Information]

2000

  • Newsome, T., Asling, B., Dickson, B. (2000). Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development, 127, 851-860.
  • Newsome, T., Schmidt, S., Dietzl, G., Keleman, K., Asling, B., Debant, A., Dickson, B. (2000). Trio Combines with Dock to Regulate Pak Activity during Photoreceptor Axon Pathfinding in Drosophila. Cell, 101, 283-294.

Selected Grants

2023

  • Protein interaction screen for retrieval of Mpox drug targets, Newsome T, Cordwell S, School of Life and Environmental Sciences (SOLES)/Strategic Partnership Seeding Grant

2022

  • Evolution of Monkeypox virus at the host-pathogen interface, Newsome T, Centre for Drug Discovery Innovation/Sydney ID Seed Funding