Thesis work
Thesis title: Anisotropic MeTro/GelMa cryogel for tendon regeneration.
Supervisors: Suzanne Mithieux, Ziyu Wang, Tony Weiss
Thesis abstract:
Tendons are fibrous tissues that connect between bones and muscles, and they are susceptible to injury, especially in athletes. Due to the limited regeneration capacity, current treatments and surgical procedures for injured tendons often fail to restore their full functionality. To improve the quality of healed tendon, we are developing an anisotropic tropoelastin/PVA hydrogel to direct regeneration of functional tendon tissue. The scaffold replicates the structural and mechanical features of a tendon, which stimulate the deposition of functional matrix by cells. Eventually, the scaffolds will degrade and be replaced by newly formed tissue that is as competent as a natural tendon.
Publications
Journals
- Wang, Z., Zhang, M., Liu, L., Mithieux, S., Weiss, A. (2024). Polyglycerol sebacate-based elastomeric materials for arterial regeneration. Journal of Biomedical Materials Research A, 112(4), 574-585. [More Information]
- Li, M., Zhang, M., Selyutina, N., Smirnov, I., Li, B., Zhang, Y., Wang, W., Jiang, L., Liu, Y., Ma, G. (2022). Chloride ion transport behavior of concrete containing insulating glazed hollow beads exposed to high temperature. Construction and Building Materials, 350. [More Information]
- Zhang, M., Wang, Z., Zhang, A., Liu, L., Mithieux, S., Bilek, M., Weiss, A. (2022). Development of tropoelastin-functionalized anisotropic PCL scaffolds for musculoskeletal tissue engineering. Regenerative Biomaterials, 10, 1-9. [More Information]
2024
- Wang, Z., Zhang, M., Liu, L., Mithieux, S., Weiss, A. (2024). Polyglycerol sebacate-based elastomeric materials for arterial regeneration. Journal of Biomedical Materials Research A, 112(4), 574-585. [More Information]
2022
- Li, M., Zhang, M., Selyutina, N., Smirnov, I., Li, B., Zhang, Y., Wang, W., Jiang, L., Liu, Y., Ma, G. (2022). Chloride ion transport behavior of concrete containing insulating glazed hollow beads exposed to high temperature. Construction and Building Materials, 350. [More Information]
- Zhang, M., Wang, Z., Zhang, A., Liu, L., Mithieux, S., Bilek, M., Weiss, A. (2022). Development of tropoelastin-functionalized anisotropic PCL scaffolds for musculoskeletal tissue engineering. Regenerative Biomaterials, 10, 1-9. [More Information]
- Wang, Z., Mithieux, S., Vindin, H., Wang, Y., Zhang, M., Liu, L., Zbinden, J., Blum, K., Yi, T., Matsuzaki, Y., Oveissi, F., Lockley, K., Waterhouse, A., Pham, T., Hawkett, B., Weiss, A., et al (2022). Rapid Regeneration of a Neoartery with Elastic Lamellae. Advanced Materials. [More Information]
2021
- Al Halawani, A., Wang, Z., Liu, L., Zhang, M., Weiss, A. (2021). Applications of Engineering Techniques in Microvasculature Design. Frontiers in Cardovascular Medicine, 8, 1-9. [More Information]