Clinical translational trials

Clinical-translational trials are a fundamental focus of our institute. In these studies, we aim to transition scientific research into clinical practice where it can be of direct benefit to patients.

Ongoing clinical translational trials
Upcoming clinical translational trials

Ongoing clinical translational trials

LIGHT-SABR – Phase I Feasibility study of Lung Cancer Radiotherapy using Real-time Dynamic Multileaf Collimator Adaptation and Radiofrequency Tracking

Project description: In this investigation, patients being treated with Stereotactic Body Radiotherapy (SBRT) for lung cancer will receive a new treatment. Beacons will be implanted into the patients' lung to allow Multi Leaf Collimator (MLC) tracking equipment to precisely follow the movement of the lung. The difference between tracking tumour movement with MLC versus the current standard method will be compared to identify any variances. Audio-visual (AV) Biofeedback will also be used to regulate patients' breathing during radiotherapy.

Project status: 12 patients accrued
Study size: 20 Stage I NSCLC patients
Sites: Royal North Shore Hospital
Contact: Vincent Caillet. E: vcai6204@uni.sydney.edu.au
Research Project: MLC Tracking


SPARK: Stereotactic Prostate Adaptive Radiotherapy utilising Kilovoltage intrafraction monitoring

Prostate motion during radiotherapy treatment delivery may shift the tumour outside the beam, simultaneously reducing target dose and exposing normal tissues to potentially damaging radiation doses.SPARK seeks to validate the use of Kilovoltage Intrafraction Monitoring (KIM) to manage intrafraction motion in the Stereotactic Body Radiotherapy (SBRT) treatment of low to intermediate risk cases of prostate cancer.SPARK is a phase II multicentre, single armed, two stage study that will measure cancer targeting accuracy and patient outcomes in 48 prostate cancer patients treated with a novel cost effective real-time targeting radiotherapy technology developed and pioneered in Australia.

Project status: 28 patients recruited
Study size: 48 prostate cancer patients
Site: Multi site
Collaborating group: TROG Cancer Research
Contact: Doan Trang Nguyen. E: d.nguyen@sydney.edu.au
Research Project: Kilovoltage Intrafraction Monitoring

AVIATOR: Audio-Visual Investigation Advancing Thoracic Radiotherapy

Project description: This investigation will involve a technological assessment of the AV biofeedback system in a clinical setting. Such an investigation will involve an assessment of patient and technician experience with AV biofeedback, looking at patient benefits, impact on image quality and treatment margins. This study will be performed across 7 radiation oncology departments across NSW and ACT, promoting the widespread clinical implementation of AV biofeedback. Performing this investigation across 7 departments will also allow for larger sample size: a total of 75 lung cancer patients. AVIATOR will be the largest study of its kind to date.

Project status: This study is underway at Calvary Mater Hospital with 10 patients recruited. Further sites are planned.
Study size: 75 lung cancer patients
Sites: Royal North Shore Hospital, Westmead Hospital, Chris O’Brien Lifehouse, Nepean Hospital, Canberra Hospital, Calvary Mater Hospital, and Gosford Hospital
Contact: Elisabeth Steiner. E: elisabeth.steiner@sydney.edu.au
Research Project: Audiovisual biofeedback

AVIATOR

The AV biofeedback system to be implemented in both the treatment (left) and imaging (right) rooms in addition to the options of utilising either goggles (left) or tablet-computer (right) as the AV biofeedback display. Such applicability in different settings in addition to its compatibility with a range of display options makes AV biofeedback suitable to the range of facility equipment across multiple departments.

Upcoming clinical translational trials

Deep Inspiration Breath Hold and BRAVEHeart

Project description: Deep Inspiration Breath Hold (DIBH) is a technique where patients take a deep breath and hold it while radiation therapy is being delivered. Filling the lungs with air increases the distance between the target of radiation therapy (a lung or breast tumour) and the heart. This reduces that chance of the heart tissue being damaged during radiation treatment. The BRAVEHeart trial utilises an audiovisual feedback device (Breathe Well) to assist the patient in controlling their breathing pattern and it will be tested in patients undergoing treatment for breast cancer.

Project status: Study proposal approved at RNSH. Further sites are planned.
Study size: 40 breast cancer patients
Sites: Royal North Shore Hospital
Contact: Elisabeth Steiner. E: elisabeth.steiner@sydney.edu.au
Research Project: Audiovisual biofeedback


Nano-X – Patient experience and acceptance of horizontal rotation

Project description: Nano-X is a new radiotherapy machine designed and built in Sydney, consisting of a patient rotation system together with a radiotherapy system. Nano-X proposes to utilise patient rotation to substantially decrease the cost and size of conventional radiotherapy machines. In this trial, we will use the Nano-X patient rotation system only, without the radiotherapy system, to rotate patient volunteers to determine their level of acceptance.

Project status: Not yet open to recruitment
Study size: 100 patients
Site: Prince of Wales Hospital
Contact: Paul Liu E: pliu4890@uni.sydney.edu.au
Research Project: Patient rotation


LARK – Liver Ablative Radiotherapy utilising Kilovoltage Intrafraction Monitoring

Project description: The LARK trial will look at treatment outcomes and treatment efficiency when incorporating KIM with SABR to treat eligible patients with primary or secondary liver cancer. Participants will have fiducial markers inserted around their tumours to allow the KIM system to track tumour movement as the patient breathes.

Project status: Not yet open to recruitment
Study size: 46 patients
Sites: Westmead Hospital, Nepean Hospital
Collaborating Group: TROG Cancer Research
Contact: Doan Trang Nguyen. E: d.nguyen@sydney.edu.au
Research Project: Kilovoltage Intrafraction Monitoring


ADAPT – Adaptive CT acquisition for personalised thoracic imaging

Project description: In this trial, Respiratory Motion Guided (RMG) 4DCBCT will be implemented for the first time on lung cancer patients. RMG-4DCBCT adapts the image acquisition as the patient’s breathing changes (i.e. if the patient breathes faster, imaging data is acquired faster). By adapting the acquisition to the dynamic patient we are able to acquire personalised images of a patients lungs for radiotherapy treatments.

Project status: Not yet open to recruitment
Study size: 30 patients
Sites: Liverpool Hospital, Macarthur Hospital
Collaborating Group: TROG Cancer Research
Contact: Ricky O’Brien. E: ricky.obrien@sydney.edu.au

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