Professor Rosemary Balleine
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Professor Rosemary Balleine

MB BS (Hons) PhD FRCPA
Clinical Professor
School of Medical Sciences/Faculty of Medicine and Health(FMH)
Phone
+61 2 8865 2800
Fax
+61 2 8865 2801
Cancer
Project titleResearch student
Mechanisms underlying homologous recombination DNA repair deficiency in ovarian cancer and association with treatment responseNikilyn NEVINS

Publications

Journals

  • Pitiyarachchi, O., Lee, Y., Sim, H., Srirangan, S., Mapagu, C., Kirk, J., Harnett, P., Balleine, R., Bowtell, D., Samimi, G., Brand, A., Marsh, D., Beale, P., Anderson, L., Bouantoun, N., Provan, P., deFazio, A., et al (2023). Older age should not be a barrier to testing for somatic variants in homologous recombination DNA repair-related genes in patients with high-grade serous ovarian carcinoma. Translational Oncology, 31. [More Information]
  • Moujaber, T., Balleine, R., Gao, B., Barner Madsen, I., Harnett, P., deFazio, A. (2022). New therapeutic opportunities for women with low-grade serous ovarian cancer. Endocrine-Related Cancer, 29(1), R1-R16. [More Information]
  • Thomas, S., Kabir, M., Butcher, B., Chou, S., Mahajan, H., Farshid, G., Balleine, R., Pathmanathan, N. (2021). Interobserver concordance in visual assessment of Ki67 immunohistochemistry in surgical excision specimens from patients with lymph node-negative breast cancer. Breast Cancer Research and Treatment, 188(3), 729-737. [More Information]

2023

  • Pitiyarachchi, O., Lee, Y., Sim, H., Srirangan, S., Mapagu, C., Kirk, J., Harnett, P., Balleine, R., Bowtell, D., Samimi, G., Brand, A., Marsh, D., Beale, P., Anderson, L., Bouantoun, N., Provan, P., deFazio, A., et al (2023). Older age should not be a barrier to testing for somatic variants in homologous recombination DNA repair-related genes in patients with high-grade serous ovarian carcinoma. Translational Oncology, 31. [More Information]

2022

  • Moujaber, T., Balleine, R., Gao, B., Barner Madsen, I., Harnett, P., deFazio, A. (2022). New therapeutic opportunities for women with low-grade serous ovarian cancer. Endocrine-Related Cancer, 29(1), R1-R16. [More Information]

2021

  • Thomas, S., Kabir, M., Butcher, B., Chou, S., Mahajan, H., Farshid, G., Balleine, R., Pathmanathan, N. (2021). Interobserver concordance in visual assessment of Ki67 immunohistochemistry in surgical excision specimens from patients with lymph node-negative breast cancer. Breast Cancer Research and Treatment, 188(3), 729-737. [More Information]

2020

  • Poulos, R., Hains, P., Shah, R., Lucas, N., Xavier, D., Manda, S., Anees, A., Koh, J., Mahboob, S., Wittman, M., Williams, S., Sykes, E., Hecker, M., Dausmann, M., Wouters, M., Yang, J., deFazio, A., Balleine, R., Tully, B., Reddel, R., Robinson, P., Zhong, Q., et al (2020). Strategies to enable large-scale proteomics for reproducible research. Nature Communications, 11(1), 3793. [More Information]

2019

  • Lucas, N., Robinson, A., Espersen, M., Mahboob, S., Xavier, D., Xue, J., Balleine, R., deFazio, A., Hains, P., Robinson, P. (2019). Accelerated Barocycler Lysis and Extraction Sample Preparation for Clinical Proteomics by Mass Spectrometry. Journal of Proteome Research, 18(1), 399-405. [More Information]
  • Tully, B., Balleine, R., Hains, P., Zhong, Q., Reddel, R., Robinson, P. (2019). Addressing the Challenges of High-Throughput Cancer Tissue Proteomics for Clinical Application: ProCan. Proteomics, 19(21-22), 1-5. [More Information]
  • Li, A., Geyer, F., Blecua, P., Lee, J., Selenica, P., Brown, D., Pareja, F., Lee, S., Kumar, R., Rivera, B., Clarke, C., et al (2019). Publisher Correction: Homologous recombination DNA repair defects in PALB2-associated breast cancers. n p j Breast Cancer, 5(1), 23. [More Information]

2018

  • Moujaber, T., Etemadmoghadam, D., Kennedy, C., Chiew, Y., Balleine, R., Saunders, C., Wain, G., Gao, B., Hogg, R., Srirangan, S., Harnett, P., deFazio, A., et al (2018). BRAF Mutations in Low-Grade Serous Ovarian Cancer and Response to BRAF Inhibition. JCO Precision Oncology, 2, 1-14. [More Information]
  • Gao, B., Lu, Y., Nieuweboer, A., Xu, H., Beesley, J., Boere, I., De Graan, A., de Bruijn, P., Gurney, H., Kennedy, C., Chiew, Y., Harnett, P., Balleine, R., deFazio, A., et al (2018). Genome-wide association study of paclitaxel and carboplatin disposition in women with epithelial ovarian cancer. Scientific Reports, 8(1), 1-10. [More Information]
  • Soon, P., Provan, P., Kim, E., Pathmanathan, N., Graham, D., Clarke, C., Balleine, R. (2018). Profiling differential microRNA expression between in situ, infiltrative and lympho-vascular space invasive breast cancer: a pilot study. Clinical and Experimental Metastasis, 35(1-2), 3-13. [More Information]

2016

  • Fox, P., Balleine, R., Lee, C., Gao, B., Balakrishnar, B., Menzies, A., Yeap, S., Ali, S., Gebski, V., Provan, P., Liddle, C., Hui, R., Kefford, R., Wong, K., Wilcken, N., Gurney, H., et al (2016). Dose escalation of tamoxifen in patients with low endoxifen level: Evidence for therapeutic drug monitoring - The TADE study. Clinical Cancer Research, 22(13), 3164-3171. [More Information]
  • Hollestelle, A., van der Baan, F., Berchuck, A., Johnatty, S., Aben, K., Agnarsson, B., Aittomaki, K., Alducci, E., Andrulis, I., Balleine, R., Carter, J., deFazio, A., et al (2016). No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. Gynecologic Oncology, 141(2), 386-401. [More Information]
  • Gao, B., Lindemann, K., Anderson, L., Fereday, S., Hung, J., Alsop, K., Tothill, R., Gebski, V., Kennedy, C., Balleine, R., Harnett, P., deFazio, A., et al (2016). Serous ovarian and primary peritoneal cancers: A comparative analysis of clinico-pathological features, molecular subtypes and treatment outcome. Gynecologic Oncology, 142(3), 458-464. [More Information]

2015

  • Pirie, A., Guo, Q., Kraft, P., Canisius, S., Eccles, D., Rahman, N., Nevanlinna, H., Chen, C., Khan, S., Tyrer, J., Balleine, R., et al (2015). Common germline polymorphisms associated with breast cancer-specific survival. Breast Cancer Research, 17(1), 1-11. [More Information]
  • Guo, Q., Schmidt, M., Kraft, P., Canisius, S., Chen, C., Khan, S., Tyrer, J., Bolla, M., Wang, Q., Dennis, J., Balleine, R., et al (2015). Identification of novel genetic markers of breast cancer survival. Journal of the National Cancer Institute, 107(5), 1-9. [More Information]
  • Mavaddat, N., Pharoah, P., Michailidou, K., Tyrer, J., Book, M., Bolla, M., Wang, Q., Dennis, J., Dunning, A., Shah, M., Balleine, R., Carpenter, J., Clarke, C., et al (2015). Prediction of breast cancer risk based on profiling with common genetic variants. Journal of the National Cancer Institute, 107(5), 1-15. [More Information]

2014

  • Purrington, K., Slettedahl, S., Bolla, M., Michailidou, K., Czene, K., Nevanlinna, H., Bojesen, S., Andrulis, I., Cox, A., Per, H., Clarke, C., Balleine, R., et al (2014). Genetic variation in mitotic regulatory pathway genes is associated with breast tumor grade. Human Molecular Genetics, 23(22), 6034-6046. [More Information]
  • Emmanuel, C., Chiew, Y., George, J., Etemadmoghadam, D., Anglesio, M., Sharma, R., Russell, P., Kennedy, C., Fereday, S., Hung, J., Hogg, R., Wain, G., Brand, A., Balleine, R., Clarke, C., Harnett, P., deFazio, A., et al (2014). Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver. Clinical Cancer Research, 20(24), 6618-6630. [More Information]
  • Gao, B., Russell, A., Beesley, J., Chen, X., Healey, S., Henderson, M., Wong, K., Emmanuel, C., Galletta, L., Johnatty, S., Harnett, P., Balleine, R., deFazio, A., et al (2014). Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer. Scientific Reports, 4, 1-9. [More Information]

2013

  • Garcia-Closas, M., Couch, F., Lindstrom, S., Michailidou, K., Schmidt, M., Brook, M., Orr, N., Rhie, S., Riboli, E., Feigelson, H., Carpenter, J., Balleine, R., et al (2013). Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nature Genetics, 45(4), 392-398. [More Information]
  • Pathmanathan, N., Balleine, R. (2013). Ki67 and proliferation in breast cancer. Journal of Clinical Pathology, 66(6), 512-516. [More Information]
  • Webster, L., Provan, P., Graham, J., Byth Wilson, K., Walker, R., Davis, S., Salisbury, E., Morey, A., Ward, R., Hawkins, N., Clarke, C., Balleine, R., et al (2013). Prohibitin expression is associated with high grade breast cancer but is not a driver of amplification at 17q21.33. Pathology, 45(7), 629-636. [More Information]

2012

  • Pathmanathan, N., Provan, P., Mahajan, H., Hall, G., Byth Wilson, K., Bilous, M., Balleine, R. (2012). Characteristics of HER2-positive breast cancer diagnosed following the introduction of universal HER2 testing. The Breast, 21(6), 724-729. [More Information]
  • Khushi, M., Carpenter, J., Balleine, R., Clarke, C. (2012). Development of a data entry auditing protocol and quality assurance for a tissue bank database. Cell and Tissue Banking, 13(1), 9-13. [More Information]
  • Khushi, M., Carpenter, J., Balleine, R., Clarke, C. (2012). Electronic Biorepository Application System: Web-Based Software to Manage Receipt, Peer Review, and Approval of Researcher Applications. Biopreservation and Biobanking, 10(1), 37-44. [More Information]

2011

  • Haiman, C., Chen, G., Vachon, C., Canzian, F., Dunning, A., Millikan, R., Wang, X., Ademuyiwa, F., Ahmed, S., Ambrosone, C., Balleine, R., Carpenter, J., Clarke, C., et al (2011). A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nature Genetics, 43(12), 1210-1215. [More Information]
  • Stevens, K., Vachon, C., Lee, A., Slager, S., Lesnick, T., Oswald, C., Fasching, P., Miron, P., Carpenter, J., Clarke, C., Balleine, R., et al (2011). Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer. Cancer Research, 71(19), 6240-6249. [More Information]
  • Emmanuel, C., Gava, N., Kennedy, C., Balleine, R., Sharma, R., Wain, G., Brand, A., Hogg, R., Etemadmoghadam, D., George, J., Clarke, C., Harnett, P., deFazio, A., et al (2011). Comparison of Expression Profiles in Ovarian Epithelium In Vivo and Ovarian Cancer Identifies Novel Candidate Genes Involved in Disease Pathogenesis. PloS One, 6(3), e17617-1-e17617-18. [More Information]

2010

  • Pathmanathan, N., Salisbury, E., Provan, P., Bilous, M., Byth Wilson, K., Milliken, J., Clarke, C., Balleine, R. (2010). A class discovery and class prediction approach to histopathological classification of mammographic screen detected columnar cell lesions of the breast. Pathology, 42(1), 28-36. [More Information]
  • Spurdle, A., Lakhani, S., Da Silva, L., Balleine, R., kConFab Investigators, Goldgar, D. (2010). Bayes Analysis Provides Evidence of Pathogenicity for the BRCA1 c.135-1G>T (IVS3-1) and BRCA2 c.7977-1G>C (IVS17-1) Variants Displaying In Vitro Splicing Results of Equivocal Clinical Significance. Human Mutation, 31(2), E1141-E1145. [More Information]
  • Pathmanathan, N., Albertini, A., Provan, P., Milliken, J., Salisbury, E., Bilous, M., Byth Wilson, K., Balleine, R. (2010). Diagnostic evaluation of papillary lesions of the breast on core biopsy. Modern Pathology, 23(7), 1021-1028. [More Information]

2009

  • Graham, J., Mote, P., Salagame, U., Van Dijk, J., Balleine, R., Huschtscha-Holliday, L., Reddel, R., Clarke, C. (2009). DNA replication licensing and progenitor numbers are increased by progesterone in normal human breast. Endocrinology, 150(7), 3318-3326. [More Information]
  • Graham, J., Mote, P., Salagame, U., Balleine, R., Huschtscha-Holliday, L., Clarke, C. (2009). Hormone-Responsive Model of Primary Human Breast Epithelium. Journal of Mammary Gland Biology and Neoplasia, 14(4), 367-379. [More Information]

2008

  • Scurr, L., Guminski, A., Chiew, Y., Balleine, R., Sharma, R., Lei, Y., Pryor, K., Wain, G., Brand, A., Byth, K., Kennedy, C., Rizos, H., Harnett, P., deFazio, A. (2008). Ankyrin Repeat Domain 1, ANKRD1, a Novel Determinant of Cisplatin Sensitivity Expressed in Ovarian Cancer. Clinical Cancer Research, 14(21), 6924-6932. [More Information]
  • Loughrey, M., Provan, P., Byth Wilson, K., kConFab Investigators, Balleine, R. (2008). Histopathological features of ''BRCAX'' familial breast cancers in the kConFab resource. Pathology, 40(4), 352-358. [More Information]
  • Balleine, R., Webster, L., Davis, S., Salisbury, E., Palazzo, J., Schwartz, G., Cornfield, D., Walker, R., Byth Wilson, K., Clarke, C., et al (2008). Molecular Grading of Ductal Carcinoma In situ of the Breast. Clinical Cancer Research, 14(24), 8244-8252. [More Information]

2007

  • Gurney, H., Wong, M., Balleine, R., Rivory, L., McLachlan, A., Hoskins, J., Wilcken, N., Clarke, C., Mann, G., Collins, M., et al (2007). Imatinib Disposition and ABCB1 (MDR1, P-Glycoprotein) Genotype. Clinical Pharmacology & Therapeutics, 82(1), 33-40. [More Information]

2006

  • Mann, G., Thorne, H., Balleine, R., Butow, P., Clarke, C., Edkins, E., Evans, G., Fereday, S., Haan, E., Gattas, M., Kirk, J., Leary, J., Pupo, G., et al (2006). Analysis of cancer risk and BRCA1 and BRCA2 mutation prevalence in the kConFab familial breast cancer resource. Breast Cancer Research, 8(1), 1-15. [More Information]
  • Balleine, R., Murali, R., Bilous, M., Farshid, G., Waring, P., Provan, P., Byth Wilson, K., Thorne, H., KConFab, C., Kirk, J. (2006). Histopathological features of breast cancer in carriers of ATM gene variants. Histopathology, 49(5), 523-532. [More Information]
  • Farshid, G., Balleine, R., Cummings, M., Waring, P., The Kathleen Cunningham Consortium for Research into Familial Breast Cancer. (2006). Morphology of Breast Cancer as a Means of Triage of Patients for BRCA1 Genetic Testing. American Journal of Surgical Pathology, 30(11), 1357-1366. [More Information]

2005

  • Wong, M., Evans, S., Rivory, L., Hoskins, J., Mann, G., Farlow, D., Clarke, C., Balleine, R., Gurney, H. (2005). Hepatic technetium Tc 99m-labeled sestamibi elimination rate and ABCB1 (MDR1) genotype as indicators of ABCB1 (P-glycoprotein) activity in patients with cancer. Clinical Pharmacology & Therapeutics, 77(1), 33-42. [More Information]
  • Webster, L., Bilous, M., Willis, L., Byth Wilson, K., Burgemeister, F., Salisbury, E., Clarke, C., Balleine, R. (2005). Histopathologic indicators of breast cancer biology: insights from population mammographic screening. British Journal of Cancer, 92(8), 1366-1371. [More Information]
  • Byrne, J., Balleine, R., Fejzo, M., Mercieca, J., Chiew, Y., Livnat, Y., St.Heaps, L., Peters, G., Byth Wilson, K., Karlan, B., Harnett, P., deFazio, A., et al (2005). Tumor protein D52 (TPD52) is overexpressed and a gene amplification target in ovarian cancer. International Journal of Cancer, 117(6), 1049-54. [More Information]

2004

  • Wong, M., Balleine, R., Collins, M., Liddle, C., Clarke, C., Gurney, H. (2004). Cyp3A5 Genotype And Midazolam Clearance In Australian Patients Receiving Chemotherapy. Pharmacology and Therapeutics, 75(6), 529-538. [More Information]
  • Balleine, R., Earls, P., Webster, L., Mote, P., deFazio, A., Harnett, P., Clarke, C. (2004). Expression Of Progesterone Receptor A And B Isoforms In Low-Grade Endometrial Stromal Sarcoma. International Journal of Gynecological Pathology, 23(2), 138-144. [More Information]

2001

  • Balleine, R., Humphrey, K., Clarke, C. (2001). Tumour banks: providing human tissue for cancer research. Medical Journal of Australia, 175, 293-294.

2000

  • Mote, P., Balleine, R., McGowan, E., Clarke, C. (2000). Heterogeneity of progesterone receptors A and B expression in human endometrial glands and stroma. Human Reproduction, 15(supp3), 48-56. [More Information]
  • Balleine, R., Schoenberg Fejzo, M., Sathasivam, P., Basset, P., Clarke, C., Byrne, J. (2000). The hD52 (TDP52) gene is a candidate target gene for events resulting in increased 8q21 copy number in human breast carcinoma. Genes Chromosomes and Cancer, 29(1), 48-57.

Selected Grants

2023

  • Pre-clinical testing of combined MEK and CDK4/6 inhibition for Low-Grade Serous Ovarian Cancer, Moujaber T, deFazio A, Balleine R, Australia New Zealand Gynaecological Oncology Group/Fund for New Research Grant Program

2021

  • Accelerating paediatric cancer precision medicine with mass spectrometry-based proteomics, Poulos R, Reddel R, Zhong Q, Robinson P, Cowley M, Lau L, Ziegler D, Balleine R, National Health and Medical Research Council (NHMRC)/Ideas Grant