People_

Professor Andrew Harman

Professor of Virology and Immunology
School of Medical Sciences
Faculty of Medicine and Health

Phone

+61 2 8627 3623

Email

andrew.harman@sydney.edu.au

Details

Member of the Charles Perkins Centre

Websites

Member of: Sydney Infectious Diseases Institute (Sydney ID)

Biographical details

Andrew Harman is a Professor of Virology and Immunology in the School of Medical Sciences theme of Infection, Immunity and Inflammation. He is the academic lead for the FMH/SOMS High School Outreach program. He is also the Co-Director of the Centre for Virus Research at the Westmead Institute for Medical Research (WIMR).

Research interests

Andrew's primary interest is in mucosal immunology and investigating the dynamics of sexual transmission of HIV. He has developed extensive collaborations with a range of sexual health specialists, as well as plastic, colorectal, gynaecological and urological surgeons.Therefore he has access to all the human tissues that sexually transmitted pathogens encounter during sexual intercourse (labia, vagina, cervix, foreskin, glans penis, penile urethra, anus and rectum). Regular access to these tissues gives his group a translational cutting edge as they are the only research groups worldwide that has access to such a comprehensive range of anogenital tissues. Andrew's group also has access to human intestinal tissue and they also investigate the mucosal immunology associated with Autoinflammatory Diseases such as Crohn's disease and Ulcerative Colitis.

Teaching and supervision

Andrew has designed and implemented SOMS 4102: Communicating Ideas in Biomedical Science. This is an honours coursework unit of study which teaches students to critically analyse and communicate their research through a variety of mediums.

Associations

The Westmead Institute for Medical Research

Sydney Institute for Infectious Diseases (Sydney ID)

Charles Perkins Centre

Australian Centre for HIV and Hepatitis Medicine (ACH2)

Australian Society for HIV Medicine (ASHM)

Australasian Virology Society (AVS)

Australaisian Society for Immunology (ASI)

International Society for Mucosal Imunology

Awards and honours

Westmead Institute Scientific Excellence (WISE) Award (2020)

Best poster presentation, International Congress of Mucosal Immunology (2019)

Westmead Millennium Institute Science Prize (2007, 2009, 2011)

Best oral presentation, Westmead Hospital Research Symposium (2010)

Purse Scholarship, Gonville and Caius College Cambridge (1998 – 2002)

Welcome Trust Prize PhD Studentship (1998 – 2002)

Themes

Infection and Immunological Conditions

Keywords

HIV/AIDS, Crohn's Disease, Mucosal Immunology, Mononuclear Phagocytes, Inflamatory Bowel Disease

Approaches

Cellular/Molecular, Immunology, Translational Research

International links

South Africa	(Regan Institute) Collaboration with Henrik Kloverpris to provide HIV infected intestinal biopsies
United Kingdom	(University of Newcastle) Collaboration with Prof Muzlifah Haniffa in mononuclear phagocyte function
United States	(Emory University) Collaboration with Prof Eric Hunter on sexual transmission of HIV
United States	(Oregon Health and Science University) Collaboration with Prof Jacob Estes in sexual transmission of HIV
United States	(University of California, Davis) Collaboration with Prof Barbara Schacklett of mucosal immunology and HIV
United States	(University of Washington) Collaboration with Prof Michael Gale on innate immunity and HIV

Current research students

Project title	Research student
Determining the Drivers of Migration for HIV Target Myeloid Dendritic Cells across the Epithelial Layer and Determining Their Capacity for CD4+ T-Cell Stimulation.	Daniel BUFFA
Investigating neuroimmune mechanisms that underpin sexual dimorphism and complex behavioural disturbances of chronic neuropathic pain in preclinical models and identifying neuroimmune correlates of treatment response to Cannabidiol in humans	Fred COLLIN
Investigating neuroimmune interactions in chronic neuropathic pain conditions using high-parameter cytometry technologies.	Jackson KARRASCH
Defining mononuclear phagocytes in inflamed anogenital tissue and their role in HIV acquisition	Freja WARNER VAN DIJK

Publications

By Type

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Book Chapters

Nasr, N., Harman, A., Turville, S., Cunningham, A. (2014). HIV infection of dendritic cells. In Elisa Vincenzi, Guido Poli (Eds.), Human Retroviruses: Method and Protocols, (pp. 221-232). New York: Humana Press. [More Information]
Cunningham, A., Harman, A., Kim, M., Nasr, N., Lai, J. (2013). Immunobiology of Dendritic Cells and the Influence of HIV Infection. In Li Wu, Olivier Schwartz (Eds.), HIV Interactions with Dendritic Cells: Infection and Immunity, (pp. 1-44). New York, USA: Springer Science+Business Media. [More Information]

Journals

Hu, K., O'Neil, T., Baharlou, H., Austin, P., Karrasch, J., Sarkawt, L., Li, Y., Bertram, K., Cunningham, A., Patrick, E., Harman, A. (2025). The spatial biology of HIV infection. PLoS Pathogens, 21(1), e1012888. [More Information]
Warner Van Dijk, F., Tong, O., Oneil, T., Bertram, K., Hu, K., Baharlou, H., Vine, E., Jenns, K., Gosselink, M., Toh, J., Harman, A., Nasr, N., et al (2024). Characterising plasmacytoid and myeloid AXL+ SIGLEC6+ dendritic cell functions and their interactions with HIV. PLoS Pathogens, 20(6), e1012351. [More Information]
Vine, E., Austin, P., O'Neil, T., Nasr, N., Bertram, K., Cunningham, A., Harman, A. (2024). Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccines. Cell Reports, 43(4), 113977. [More Information]
Rana, H., Truong (Osborne), N., Johnon, B., Baharlou, H., Herbert, J., Kandasamy, S., Goddard, R., Cohen, R., Wines, M., Nasr, N., Harman, A., Bertram, K., Sandgren, K., Cunningham, A. (2024). Herpes simplex virus spreads rapidly in human foreskin, partly driven by chemokine-induced redistribution of Nectin-1 on keratinocytes. PLoS Pathogens, 20(6 June), e1012267. [More Information]
Hu, K., Harman, A., Baharlou, H. (2024). Imaging Mass Cytometry for In Situ Immune Profiling. Methods in Molecular Biology, 2779, 407-423. [More Information]
Hu, K., O'Neil, T., Canete, N., Baharlou, H., Harman, A. (2024). OMIP-103: A 35-marker imaging mass cytometry panel for the co-detection of HIV and immune cell populations in human formalin fixed paraffin embedded intestinal tissue. Cytometry Part A. [More Information]
Bertram, K., Oneil, T., Vine, E., Baharlou, H., Cunningham, A., Harman, A. (2023). Defining the landscape of human epidermal mononuclear phagocytes. Immunity, 56(3), 459-460. [More Information]
O'Brien, J., Karrasch, J., Huang, Y., Vine, E., Cunningham, A., Harman, A., Austin, P. (2023). Nerve-myeloid cell interactions in persistent human pain: a reappraisal using updated cell subset classifications. Pain, 165(4), 753-771. [More Information]
O'Neil, T., Harman, A., Cunningham, A., Nasr, N., Bertram, K. (2023). OMIP-096: A 24-color flow cytometry panel to identify and characterize CD4+ and CD8+ tissue-resident T cells in human skin, intestinal, and type II mucosal tissue. Cytometry Part A, 103(11), 851-856. [More Information]
Patrick, E., Canete, N., Iyengar, S., Harman, A., Sutherland, G., Yang, P. (2023). Spatial analysis for highly multiplexed imaging data to identify tissue microenvironments. Cytometry Part A, 103, 593-599. [More Information]
Speck, P., Mackenzie, J., Bull, R., Slobedman, B., Abendroth, A., Harman, A., Tu, T., Ashley, C., Petrone, M., Samer, C., Cunningham, A., Mahar, J., Newsome, T., Nasr, N., et al (2023). Statement in Support of: "Virology under the Microscope - a Call for Rational Discourse". mSphere, 8(3). [More Information]
Speck, P., Mackenzie, J., Bull, R., Slobedman, B., Abendroth, A., Harman, A., Tu, T., Ashley, C., Petrone, M., Samer, C., Cunningham, A., Mahar, J., Newsome, T., Nasr, N., et al (2023). Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”. Journal of Virology, 97(5). [More Information]
Speck, P., Mackenzie, J., Bull, R., Slobedman, B., Abendroth, A., Harman, A., Tu, T., Ashley, C., Petrone, M., Samer, C., Cunningham, A., Mahar, J., Newsome, T., Nasr, N., et al (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mBio, 14(3). [More Information]
Baharlou, H., Canete, N., Vine, E., Hu, K., Yuan, D., Sandgren, K., Bertram, K., Nasr, N., Rhodes, J., Gosselink, M., Patrick, E., Byrne, S., Cunningham, A., Harman, A., et al (2022). An in situ analysis pipeline for initial host-pathogen interactions reveals signatures of human colorectal HIV transmission. Cell Reports, 40(12), 111385-1-111385-27. [More Information]
Vine, E., Rhodes, J., Warner Van Dijk, F., Byrne, S., Bertram, K., Cunningham, A., Harman, A. (2022). HIV transmitting mononuclear phagocytes; integrating the old and new. Mucosal Immunology, 15(4), 542-550. [More Information]
Schroder, A., Chami, B., Liu, C., Doyle, C., El Kazzi, M., Ahlenstiel, G., Ahmad, G., Pathma-Nathan, N., Collins, G., Toh, J., Harman, A., Byrne, S., Witting, P., et al (2022). Neutrophil Extracellular Trap Density Increases With Increasing Histopathological Severity of Crohn's Disease. Inflammatory Bowel Diseases, 28(4), 586-598. [More Information]
Doyle, C., Fewings, N., Ctercteko, G., Byrne, S., Harman, A., Bertram, K. (2022). OMIP 082: A 25-color phenotyping to define human innate lymphoid cells, natural killer cells, mucosal-associated invariant T cells, and γδ T cells from freshly isolated human intestinal tissue. Cytometry Part A, 101(3), 196-202. [More Information]
Canete, N., Iyengar, S., Ormerod, J., Baharlou, H., Harman, A., Patrick, E. (2022). spicyR: spatial analysis of in situ cytometry data in R. Bioinformatics, 38(11), 3099-3155. [More Information]
Baharlou, H., Canete, N., Bertram, K., Sandgren, K., Cunningham, A., Harman, A., Patrick, E. (2021). AFid: a tool for automated identification and exclusion of autofluorescent objects from microscopy images. Bioinformatics, 37(4), 559-567. [More Information]
Bertram, K., Truong (Osborne), N., Smith, J., Kim, M., Sandgren, K., Feng, K., Herbert, J., Rana, H., Danastas, K., Miranda Saksena, M., Rhodes, J., Cohen, R., Harman, A., Cunningham, A., et al (2021). Herpes Simplex Virus type 1 infects Langerhans cells and the novel epidermal dendritic cell, Epi-cDC2s, via different entry pathways. PLoS Pathogens, 17(4), e1009536. [More Information]
Rhodes, J., Botting, R., Bertram, K., Vine, E., Rana, H., Baharlou, H., Vegh, P., O'Neil, T., Ashhurst, A., Fletcher, J., Parnell, G., Graham, J., Nasr, N., Gosselink, M., Di Re, A., Reza, F., Ctercteko, G., Patrick, E., Byrne, S., Cunningham, A., Harman, A., et al (2021). Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells. Nature Communications, 12, Article 2147-15 pages. [More Information]
Oulee, A., Ma, F., Teles, R., de Andrade Silva, B., Pellegrini, M., Klechevsky, E., Harman, A., Rhodes, J., Modlin, R. (2021). Identification of Genes Encoding Antimicrobial Proteins in Langerhans Cells. Frontiers in Immunology, 12, 695373. [More Information]
Doyle, C., Vine, E., Bertram, K., Baharlou, H., Rhodes, J., Dervish, S., Gosselink, M., Di Re, A., Collins, G., Reza, F., Pathma-Nathan, N., Ahlenstiel, G., Ctercteko, G., Cunningham, A., Harman, A., Byrne, S., et al (2021). Optimal Isolation Protocols for Examining and Interrogating Mononuclear Phagocytes From Human Intestinal Tissue. Frontiers in Immunology, 12, 727952. [More Information]
Tong, O., Duette, G., O'Neil, T., Royle, C., Rana, H., Johnon, B., Popovic, N., Dervish, S., Brouwer, M., Baharlou, H., Palmer, S., Harman, A., Cunningham, A., Nasr, N., et al (2021). Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype. PLoS Pathogens, 17(4), e1009522. [More Information]
Robertson, H., Li, J., Kim, H., Rhodes, J., Harman, A., Patrick, E., Rogers, N. (2021). Transcriptomic Analysis Identifies A Tolerogenic Dendritic Cell Signature. Frontiers in Immunology, 12(Published 20 October 2021), 733231 - 1-733231 - 14. [More Information]
van der Sluis, R., Zerbato, J., Rhodes, J., Pascoe, R., Solomon, A., Kumar, N., Dantanarayana, A., Tennakoon, S., Dufloo, J., McMahon, J., Harman, A., et al (2020). Diverse effects of interferon alpha on the establishment and reversal of HIV latency. PLoS Pathogens, 16(2), e1008151. [More Information]
Singh, K., Zerbato, J., Zhao, W., Braat, S., Deleage, C., Surekha Tennakoon, G., Mason, H., Dantanarayana, A., Rhodes, A., Rhodes, J., Harman, A., et al (2020). Intrahepatic CXCL10 is strongly associated with liver fibrosis in HIV-Hepatitis B coinfection. PLoS Pathogens, 16(9), e1008744. [More Information]
Rhodes, J., Tong, O., Harman, A., Turville, S. (2019). Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection. Frontiers in Immunology, 10, 1-24. [More Information]
Bertram, K., Botting, R., Baharlou, H., Rhodes, J., Rana, H., Graham, J., Patrick, E., Fletcher, J., Plasto, T., Truong (Osborne), N., Royle, C., Doyle, C., Tong, O., Nasr, N., Cunningham, A., Harman, A., et al (2019). Identification of HIV transmitting CD11c+ human epidermal dendritic cells. Nature Communications, 10(1), 1-15. [More Information]
Bertram, K., Tong, O., Royle, C., Turville, S., Nasr, N., Cunningham, A., Harman, A. (2019). Manipulation of Mononuclear Phagocytes by HIV: Implications for Early Transmission Events. Frontiers in Immunology, 10, 1-14. [More Information]
Baharlou, H., Canete, N., Cunningham, A., Harman, A., Patrick, E. (2019). Mass Cytometry Imaging for the Study of Human Diseases - Applications and Data Analysis Strategies. Frontiers in Immunology, 10, 1-22. [More Information]
Gosselink, M., Harman, A., Ctercteko, G. (2019). Why is a haemorrhoid never infected? Colorectal Disease, 21(4), 385-386. [More Information]
Botting, R., Rana, H., Bertram, K., Rhodes, J., Baharlou, H., Nasr, N., Cunningham, A., Harman, A. (2017). Langerhans cells and sexual transmission of HIV and HSV. Reviews in Medical Virology, 27(2), e1923. [More Information]
Nasr, N., Alshehri, A., Wright, T., Shahid, M., Heiner, B., Harman, A., Botting, R., Helbig, K., Beard, M., Suzuki, K., Cunningham, A., et al (2017). Mechanism of interferon-stimulated gene induction in HIV-1- infected macrophages. Journal of Virology, 91(20), 1-19. [More Information]
Botting, R., Bertram, K., Baharlou, H., Sandgren, K., Fletcher, J., Rhodes, J., Rana, H., Plasto, T., Wang, X., Lim, J., Cunningham, A., Harman, A., et al (2017). Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes. Journal of Leukocyte Biology, 101(6), 1393-1403. [More Information]
Saleh, S., Lu, H., Evans, V., Harrison, D., Zhou, J., Jaworowski, A., Sallmann, G., Cheong, K., Mota, T., Harman, A., Cunningham, A., et al (2016). HIV integration and the establishment of latency in CCL19-treated resting CD4(+) T cells require activation of NF-[subscript K]B. Retrovirology, 13(1), 1-12. [More Information]
Clark, G., Kupresanin, F., Fromm, P., Ju, X., Muusers, L., Silveira, P., Elgundi, Z., Gasiorowski, R., Papadimitrious, M., Bryant, C., Lee, K., Harman, A., Hart, D., et al (2016). New insights into the phenotype of human dendritic cell populations. Clinical & Translational Immunology, 5(1), 1-12. [More Information]
Marsden, V., Donaghy, H., Bertram, K., Harman, A., Nasr, N., Keoshkerian, E., Merten, S., Lloyd, A., Cunningham, A. (2015). Herpes Simplex Virus Type 2-Infected Dendritic Cells Produce TNF-a, Which Enhances CCR5 Expression and Stimulates HIV Production from Adjacent Infected Cells. Journal of Immunology, 194(9), 4438-4445. [More Information]
Harman, A., Nasr, N., Feetham, A., Galoyan, A., Alshehri,, A., Rambukwelle, D., Botting, R., Hiener, B., Diefenbach, E., Diefenbach, R., Kim, M., Cunningham, A., et al (2015). HIV blocks interferon induction in human dendritic cells and macrophages by dysregulation of TBK1. Journal of Virology, 89(13), 6575-6584. [More Information]
Kim, M., Truong (Osborne), N., James, V., Bosnjak, L., Sandgren, K., Harman, A., Nasr, N., Bertram, K., Olbourne, N., Sawleshwarkar, S., Cunningham, A., et al (2015). Relay of herpes simplex virus between Langerhans cells and dermal dendritic cells in human skin. PLoS Pathogens, 11(4), 1-19. [More Information]
Nasr, N., Lai, J., Botting, R., Mercier, S., Harman, A., Kim, M., Turville, S., Center, R., Domagala, T., Gorry, P., Cunningham, A., et al (2014). Inhibition of Two Temporal Phases of HIV-1 Transfer from Primary Langerhans Cells to T Cells: The Role of Langerin. Journal of Immunology, 193(5), 2554-2564. [More Information]
Wightman, F., Hao, K., Solomon, A., Saleh, S., Harman, A., Cunningham, A., Gray, L., Churchill, M., Cameron, P., Dear, A., et al (2013). Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells. AIDS, 27(18), 2853-2862. [More Information]
Harman, A., Bye, C., Nasr, N., Sandgren, K., Kim, M., Mercier, S., Botting, R., Lewin, S., Cunningham, A., Cameron, P. (2013). Identification of Lineage Relationships and Novel Markers of Blood and Skin Human Dendritic Cells. Journal of Immunology, 190(1), 66-79. [More Information]
Cunningham, A., Harman, A., Nasr, N. (2013). Initial HIV mucosal infection and dendritic cells. EMBO Molecular Medicine, 5(5), 658-660. [More Information]
Mercier, S., Donaghy, H., Botting, R., Turville, S., Harman, A., Nasr, N., Ji, H., Kusebauch, U., Mendoza, L., Shteynberg, D., Cunningham, A., et al (2013). The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell Infection and Maturation and Enhances Adhesion to and Activation of T Lymphocytes. PLoS Pathogens, 9(10), 1-18. [More Information]
Harman, A., Kim, M., Nasr, N., Sandgren, K., Cameron, P. (2013). Tissue dendritic cells as portals for HIV entry. Reviews in Medical Virology, 23(5), 319-333. [More Information]
Nasr, N., Maddocks, S., Turville, S., Harman, A., Woolger, N., Helbig, K., Wilkinson, J., Bye, C., Wright, T., Rambukwelle, D., Donaghy, H., Cunningham, A., et al (2012). HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. Blood, 120(4), 778-788. [More Information]
Harman, A., Lai, J., Turville, S., Samarajiwa, S., Gray, L., Marsden, V., Mercier, S., Jones, K., Nasr, N., Rustagi, A., Cunningham, A., et al (2011). HIV infection of dendritic cells subverts the interferon induction pathway via IRF1 and inhibits type 1 interferon production. Blood, 118(2), 298-308. [More Information]
Cameron, P., Saleh, S., Sallmann, G., Solomon, A., Wightman, F., Evans, V., Boucher, G., Haddad, E., Sekaly, R., Harman, A., Cunningham, A., et al (2010). Establishment of HIV-1 Latency in Resting CD4+ T Cells Depends on Chemokine-Induced Changes in the Actin Cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America, 107(39), 16934-16939. [More Information]
Cunningham, A., Donaghy, H., Harman, A., Turville, S. (2010). Manipulation of dendritic cell function by viruses. Current Opinion in Microbiology, 13(4), 524-9. [More Information]
Harman, A., Kraus, M., Bye, C., Byth Wilson, K., Turville, S., Tang, O., Mercier, S., Nasr, N., Stern, J., Slobedman, B., Cunningham, A., et al (2009). HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase. Blood, 114(1), 85-94. [More Information]
Lai, J., Bernhard, O., Turville, S., Harman, A., Wilkinson, J. (2009). Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1. Journal of Biological Chemistry, 284(17), 11027-11038. [More Information]
Donaghy, H., Bosnjak, L., Harman, A., Marsden, V., Tyring, S., Meng, T., Cunningham, A. (2009). Role for Plasmacytoid Dendritic Cells in the Immune Control of Recurrent Human Herpes Simplex Virus Infection. Journal of Virology, 83(4), 1952-1961. [More Information]
Cunningham, A., Harman, A., Donaghy, H. (2007). DC-SIGN 'AIDS' HIV immune evasion and infection. Nature Immunology, 8(6), 556-558. [More Information]
Watson, S., Mercier, S., Bye, C., Wilkinson, J., Cunningham, A., Harman, A. (2007). Determination of suitable housekeeping genes for normalisation of quantitative real time PCR analysis of cells infected with human immunodeficiency virus and herpes viruses. Virology Journal, 4(130), 1-5. [More Information]
Harman, A., Wilkinson, J., Bye, C., Bosnjak, L., Stern, J., Nicholle, M., Lai, J., Cunningham, A. (2006). HIV Induces Maturation of Monocyte-Derived Dendritic Cells and Langerhans Cells. Journal of Immunology, 177(10), 7103-7113. [More Information]

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By Year

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2025

Hu, K., O'Neil, T., Baharlou, H., Austin, P., Karrasch, J., Sarkawt, L., Li, Y., Bertram, K., Cunningham, A., Patrick, E., Harman, A. (2025). The spatial biology of HIV infection. PLoS Pathogens, 21(1), e1012888. [More Information]

2024

Warner Van Dijk, F., Tong, O., Oneil, T., Bertram, K., Hu, K., Baharlou, H., Vine, E., Jenns, K., Gosselink, M., Toh, J., Harman, A., Nasr, N., et al (2024). Characterising plasmacytoid and myeloid AXL+ SIGLEC6+ dendritic cell functions and their interactions with HIV. PLoS Pathogens, 20(6), e1012351. [More Information]
Vine, E., Austin, P., O'Neil, T., Nasr, N., Bertram, K., Cunningham, A., Harman, A. (2024). Epithelial dendritic cells vs. Langerhans cells: Implications for mucosal vaccines. Cell Reports, 43(4), 113977. [More Information]
Rana, H., Truong (Osborne), N., Johnon, B., Baharlou, H., Herbert, J., Kandasamy, S., Goddard, R., Cohen, R., Wines, M., Nasr, N., Harman, A., Bertram, K., Sandgren, K., Cunningham, A. (2024). Herpes simplex virus spreads rapidly in human foreskin, partly driven by chemokine-induced redistribution of Nectin-1 on keratinocytes. PLoS Pathogens, 20(6 June), e1012267. [More Information]
Hu, K., Harman, A., Baharlou, H. (2024). Imaging Mass Cytometry for In Situ Immune Profiling. Methods in Molecular Biology, 2779, 407-423. [More Information]
Hu, K., O'Neil, T., Canete, N., Baharlou, H., Harman, A. (2024). OMIP-103: A 35-marker imaging mass cytometry panel for the co-detection of HIV and immune cell populations in human formalin fixed paraffin embedded intestinal tissue. Cytometry Part A. [More Information]

show 2 more

2023

Bertram, K., Oneil, T., Vine, E., Baharlou, H., Cunningham, A., Harman, A. (2023). Defining the landscape of human epidermal mononuclear phagocytes. Immunity, 56(3), 459-460. [More Information]
O'Brien, J., Karrasch, J., Huang, Y., Vine, E., Cunningham, A., Harman, A., Austin, P. (2023). Nerve-myeloid cell interactions in persistent human pain: a reappraisal using updated cell subset classifications. Pain, 165(4), 753-771. [More Information]
O'Neil, T., Harman, A., Cunningham, A., Nasr, N., Bertram, K. (2023). OMIP-096: A 24-color flow cytometry panel to identify and characterize CD4+ and CD8+ tissue-resident T cells in human skin, intestinal, and type II mucosal tissue. Cytometry Part A, 103(11), 851-856. [More Information]
Patrick, E., Canete, N., Iyengar, S., Harman, A., Sutherland, G., Yang, P. (2023). Spatial analysis for highly multiplexed imaging data to identify tissue microenvironments. Cytometry Part A, 103, 593-599. [More Information]
Speck, P., Mackenzie, J., Bull, R., Slobedman, B., Abendroth, A., Harman, A., Tu, T., Ashley, C., Petrone, M., Samer, C., Cunningham, A., Mahar, J., Newsome, T., Nasr, N., et al (2023). Statement in Support of: "Virology under the Microscope - a Call for Rational Discourse". mSphere, 8(3). [More Information]
Speck, P., Mackenzie, J., Bull, R., Slobedman, B., Abendroth, A., Harman, A., Tu, T., Ashley, C., Petrone, M., Samer, C., Cunningham, A., Mahar, J., Newsome, T., Nasr, N., et al (2023). Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”. Journal of Virology, 97(5). [More Information]
Speck, P., Mackenzie, J., Bull, R., Slobedman, B., Abendroth, A., Harman, A., Tu, T., Ashley, C., Petrone, M., Samer, C., Cunningham, A., Mahar, J., Newsome, T., Nasr, N., et al (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mBio, 14(3). [More Information]

show 4 more

2022

Baharlou, H., Canete, N., Vine, E., Hu, K., Yuan, D., Sandgren, K., Bertram, K., Nasr, N., Rhodes, J., Gosselink, M., Patrick, E., Byrne, S., Cunningham, A., Harman, A., et al (2022). An in situ analysis pipeline for initial host-pathogen interactions reveals signatures of human colorectal HIV transmission. Cell Reports, 40(12), 111385-1-111385-27. [More Information]
Vine, E., Rhodes, J., Warner Van Dijk, F., Byrne, S., Bertram, K., Cunningham, A., Harman, A. (2022). HIV transmitting mononuclear phagocytes; integrating the old and new. Mucosal Immunology, 15(4), 542-550. [More Information]
Schroder, A., Chami, B., Liu, C., Doyle, C., El Kazzi, M., Ahlenstiel, G., Ahmad, G., Pathma-Nathan, N., Collins, G., Toh, J., Harman, A., Byrne, S., Witting, P., et al (2022). Neutrophil Extracellular Trap Density Increases With Increasing Histopathological Severity of Crohn's Disease. Inflammatory Bowel Diseases, 28(4), 586-598. [More Information]
Doyle, C., Fewings, N., Ctercteko, G., Byrne, S., Harman, A., Bertram, K. (2022). OMIP 082: A 25-color phenotyping to define human innate lymphoid cells, natural killer cells, mucosal-associated invariant T cells, and γδ T cells from freshly isolated human intestinal tissue. Cytometry Part A, 101(3), 196-202. [More Information]
Canete, N., Iyengar, S., Ormerod, J., Baharlou, H., Harman, A., Patrick, E. (2022). spicyR: spatial analysis of in situ cytometry data in R. Bioinformatics, 38(11), 3099-3155. [More Information]

show 2 more

2021

Baharlou, H., Canete, N., Bertram, K., Sandgren, K., Cunningham, A., Harman, A., Patrick, E. (2021). AFid: a tool for automated identification and exclusion of autofluorescent objects from microscopy images. Bioinformatics, 37(4), 559-567. [More Information]
Bertram, K., Truong (Osborne), N., Smith, J., Kim, M., Sandgren, K., Feng, K., Herbert, J., Rana, H., Danastas, K., Miranda Saksena, M., Rhodes, J., Cohen, R., Harman, A., Cunningham, A., et al (2021). Herpes Simplex Virus type 1 infects Langerhans cells and the novel epidermal dendritic cell, Epi-cDC2s, via different entry pathways. PLoS Pathogens, 17(4), e1009536. [More Information]
Rhodes, J., Botting, R., Bertram, K., Vine, E., Rana, H., Baharlou, H., Vegh, P., O'Neil, T., Ashhurst, A., Fletcher, J., Parnell, G., Graham, J., Nasr, N., Gosselink, M., Di Re, A., Reza, F., Ctercteko, G., Patrick, E., Byrne, S., Cunningham, A., Harman, A., et al (2021). Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells. Nature Communications, 12, Article 2147-15 pages. [More Information]
Oulee, A., Ma, F., Teles, R., de Andrade Silva, B., Pellegrini, M., Klechevsky, E., Harman, A., Rhodes, J., Modlin, R. (2021). Identification of Genes Encoding Antimicrobial Proteins in Langerhans Cells. Frontiers in Immunology, 12, 695373. [More Information]
Doyle, C., Vine, E., Bertram, K., Baharlou, H., Rhodes, J., Dervish, S., Gosselink, M., Di Re, A., Collins, G., Reza, F., Pathma-Nathan, N., Ahlenstiel, G., Ctercteko, G., Cunningham, A., Harman, A., Byrne, S., et al (2021). Optimal Isolation Protocols for Examining and Interrogating Mononuclear Phagocytes From Human Intestinal Tissue. Frontiers in Immunology, 12, 727952. [More Information]
Tong, O., Duette, G., O'Neil, T., Royle, C., Rana, H., Johnon, B., Popovic, N., Dervish, S., Brouwer, M., Baharlou, H., Palmer, S., Harman, A., Cunningham, A., Nasr, N., et al (2021). Plasmacytoid dendritic cells have divergent effects on HIV infection of initial target cells and induce a pro-retention phenotype. PLoS Pathogens, 17(4), e1009522. [More Information]
Robertson, H., Li, J., Kim, H., Rhodes, J., Harman, A., Patrick, E., Rogers, N. (2021). Transcriptomic Analysis Identifies A Tolerogenic Dendritic Cell Signature. Frontiers in Immunology, 12(Published 20 October 2021), 733231 - 1-733231 - 14. [More Information]

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2020

van der Sluis, R., Zerbato, J., Rhodes, J., Pascoe, R., Solomon, A., Kumar, N., Dantanarayana, A., Tennakoon, S., Dufloo, J., McMahon, J., Harman, A., et al (2020). Diverse effects of interferon alpha on the establishment and reversal of HIV latency. PLoS Pathogens, 16(2), e1008151. [More Information]
Singh, K., Zerbato, J., Zhao, W., Braat, S., Deleage, C., Surekha Tennakoon, G., Mason, H., Dantanarayana, A., Rhodes, A., Rhodes, J., Harman, A., et al (2020). Intrahepatic CXCL10 is strongly associated with liver fibrosis in HIV-Hepatitis B coinfection. PLoS Pathogens, 16(9), e1008744. [More Information]

2019

Rhodes, J., Tong, O., Harman, A., Turville, S. (2019). Human Dendritic Cell Subsets, Ontogeny, and Impact on HIV Infection. Frontiers in Immunology, 10, 1-24. [More Information]
Bertram, K., Botting, R., Baharlou, H., Rhodes, J., Rana, H., Graham, J., Patrick, E., Fletcher, J., Plasto, T., Truong (Osborne), N., Royle, C., Doyle, C., Tong, O., Nasr, N., Cunningham, A., Harman, A., et al (2019). Identification of HIV transmitting CD11c+ human epidermal dendritic cells. Nature Communications, 10(1), 1-15. [More Information]
Bertram, K., Tong, O., Royle, C., Turville, S., Nasr, N., Cunningham, A., Harman, A. (2019). Manipulation of Mononuclear Phagocytes by HIV: Implications for Early Transmission Events. Frontiers in Immunology, 10, 1-14. [More Information]
Baharlou, H., Canete, N., Cunningham, A., Harman, A., Patrick, E. (2019). Mass Cytometry Imaging for the Study of Human Diseases - Applications and Data Analysis Strategies. Frontiers in Immunology, 10, 1-22. [More Information]
Gosselink, M., Harman, A., Ctercteko, G. (2019). Why is a haemorrhoid never infected? Colorectal Disease, 21(4), 385-386. [More Information]

show 2 more

2017

Botting, R., Rana, H., Bertram, K., Rhodes, J., Baharlou, H., Nasr, N., Cunningham, A., Harman, A. (2017). Langerhans cells and sexual transmission of HIV and HSV. Reviews in Medical Virology, 27(2), e1923. [More Information]
Nasr, N., Alshehri, A., Wright, T., Shahid, M., Heiner, B., Harman, A., Botting, R., Helbig, K., Beard, M., Suzuki, K., Cunningham, A., et al (2017). Mechanism of interferon-stimulated gene induction in HIV-1- infected macrophages. Journal of Virology, 91(20), 1-19. [More Information]
Botting, R., Bertram, K., Baharlou, H., Sandgren, K., Fletcher, J., Rhodes, J., Rana, H., Plasto, T., Wang, X., Lim, J., Cunningham, A., Harman, A., et al (2017). Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes. Journal of Leukocyte Biology, 101(6), 1393-1403. [More Information]

2016

Saleh, S., Lu, H., Evans, V., Harrison, D., Zhou, J., Jaworowski, A., Sallmann, G., Cheong, K., Mota, T., Harman, A., Cunningham, A., et al (2016). HIV integration and the establishment of latency in CCL19-treated resting CD4(+) T cells require activation of NF-[subscript K]B. Retrovirology, 13(1), 1-12. [More Information]
Clark, G., Kupresanin, F., Fromm, P., Ju, X., Muusers, L., Silveira, P., Elgundi, Z., Gasiorowski, R., Papadimitrious, M., Bryant, C., Lee, K., Harman, A., Hart, D., et al (2016). New insights into the phenotype of human dendritic cell populations. Clinical & Translational Immunology, 5(1), 1-12. [More Information]

2015

Marsden, V., Donaghy, H., Bertram, K., Harman, A., Nasr, N., Keoshkerian, E., Merten, S., Lloyd, A., Cunningham, A. (2015). Herpes Simplex Virus Type 2-Infected Dendritic Cells Produce TNF-a, Which Enhances CCR5 Expression and Stimulates HIV Production from Adjacent Infected Cells. Journal of Immunology, 194(9), 4438-4445. [More Information]
Harman, A., Nasr, N., Feetham, A., Galoyan, A., Alshehri,, A., Rambukwelle, D., Botting, R., Hiener, B., Diefenbach, E., Diefenbach, R., Kim, M., Cunningham, A., et al (2015). HIV blocks interferon induction in human dendritic cells and macrophages by dysregulation of TBK1. Journal of Virology, 89(13), 6575-6584. [More Information]
Kim, M., Truong (Osborne), N., James, V., Bosnjak, L., Sandgren, K., Harman, A., Nasr, N., Bertram, K., Olbourne, N., Sawleshwarkar, S., Cunningham, A., et al (2015). Relay of herpes simplex virus between Langerhans cells and dermal dendritic cells in human skin. PLoS Pathogens, 11(4), 1-19. [More Information]

2014

Nasr, N., Harman, A., Turville, S., Cunningham, A. (2014). HIV infection of dendritic cells. In Elisa Vincenzi, Guido Poli (Eds.), Human Retroviruses: Method and Protocols, (pp. 221-232). New York: Humana Press. [More Information]
Nasr, N., Lai, J., Botting, R., Mercier, S., Harman, A., Kim, M., Turville, S., Center, R., Domagala, T., Gorry, P., Cunningham, A., et al (2014). Inhibition of Two Temporal Phases of HIV-1 Transfer from Primary Langerhans Cells to T Cells: The Role of Langerin. Journal of Immunology, 193(5), 2554-2564. [More Information]

2013

Wightman, F., Hao, K., Solomon, A., Saleh, S., Harman, A., Cunningham, A., Gray, L., Churchill, M., Cameron, P., Dear, A., et al (2013). Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells. AIDS, 27(18), 2853-2862. [More Information]
Harman, A., Bye, C., Nasr, N., Sandgren, K., Kim, M., Mercier, S., Botting, R., Lewin, S., Cunningham, A., Cameron, P. (2013). Identification of Lineage Relationships and Novel Markers of Blood and Skin Human Dendritic Cells. Journal of Immunology, 190(1), 66-79. [More Information]
Cunningham, A., Harman, A., Kim, M., Nasr, N., Lai, J. (2013). Immunobiology of Dendritic Cells and the Influence of HIV Infection. In Li Wu, Olivier Schwartz (Eds.), HIV Interactions with Dendritic Cells: Infection and Immunity, (pp. 1-44). New York, USA: Springer Science+Business Media. [More Information]
Cunningham, A., Harman, A., Nasr, N. (2013). Initial HIV mucosal infection and dendritic cells. EMBO Molecular Medicine, 5(5), 658-660. [More Information]
Mercier, S., Donaghy, H., Botting, R., Turville, S., Harman, A., Nasr, N., Ji, H., Kusebauch, U., Mendoza, L., Shteynberg, D., Cunningham, A., et al (2013). The Microvesicle Component of HIV-1 Inocula Modulates Dendritic Cell Infection and Maturation and Enhances Adhesion to and Activation of T Lymphocytes. PLoS Pathogens, 9(10), 1-18. [More Information]
Harman, A., Kim, M., Nasr, N., Sandgren, K., Cameron, P. (2013). Tissue dendritic cells as portals for HIV entry. Reviews in Medical Virology, 23(5), 319-333. [More Information]

show 3 more

2012

Nasr, N., Maddocks, S., Turville, S., Harman, A., Woolger, N., Helbig, K., Wilkinson, J., Bye, C., Wright, T., Rambukwelle, D., Donaghy, H., Cunningham, A., et al (2012). HIV-1 infection of human macrophages directly induces viperin which inhibits viral production. Blood, 120(4), 778-788. [More Information]

2011

Harman, A., Lai, J., Turville, S., Samarajiwa, S., Gray, L., Marsden, V., Mercier, S., Jones, K., Nasr, N., Rustagi, A., Cunningham, A., et al (2011). HIV infection of dendritic cells subverts the interferon induction pathway via IRF1 and inhibits type 1 interferon production. Blood, 118(2), 298-308. [More Information]

2010

Cameron, P., Saleh, S., Sallmann, G., Solomon, A., Wightman, F., Evans, V., Boucher, G., Haddad, E., Sekaly, R., Harman, A., Cunningham, A., et al (2010). Establishment of HIV-1 Latency in Resting CD4+ T Cells Depends on Chemokine-Induced Changes in the Actin Cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America, 107(39), 16934-16939. [More Information]
Cunningham, A., Donaghy, H., Harman, A., Turville, S. (2010). Manipulation of dendritic cell function by viruses. Current Opinion in Microbiology, 13(4), 524-9. [More Information]

2009

Harman, A., Kraus, M., Bye, C., Byth Wilson, K., Turville, S., Tang, O., Mercier, S., Nasr, N., Stern, J., Slobedman, B., Cunningham, A., et al (2009). HIV-1-infected dendritic cells show 2 phases of gene expression changes, with lysosomal enzyme activity decreased during the second phase. Blood, 114(1), 85-94. [More Information]
Lai, J., Bernhard, O., Turville, S., Harman, A., Wilkinson, J. (2009). Oligomerization of the macrophage mannose receptor enhances gp120-mediated binding of HIV-1. Journal of Biological Chemistry, 284(17), 11027-11038. [More Information]
Donaghy, H., Bosnjak, L., Harman, A., Marsden, V., Tyring, S., Meng, T., Cunningham, A. (2009). Role for Plasmacytoid Dendritic Cells in the Immune Control of Recurrent Human Herpes Simplex Virus Infection. Journal of Virology, 83(4), 1952-1961. [More Information]

2007

Cunningham, A., Harman, A., Donaghy, H. (2007). DC-SIGN 'AIDS' HIV immune evasion and infection. Nature Immunology, 8(6), 556-558. [More Information]
Watson, S., Mercier, S., Bye, C., Wilkinson, J., Cunningham, A., Harman, A. (2007). Determination of suitable housekeeping genes for normalisation of quantitative real time PCR analysis of cells infected with human immunodeficiency virus and herpes viruses. Virology Journal, 4(130), 1-5. [More Information]

2006

Harman, A., Wilkinson, J., Bye, C., Bosnjak, L., Stern, J., Nicholle, M., Lai, J., Cunningham, A. (2006). HIV Induces Maturation of Monocyte-Derived Dendritic Cells and Langerhans Cells. Journal of Immunology, 177(10), 7103-7113. [More Information]

Selected Grants

2023

Defining the Role of Antigen Presenting Cells in Crohns Disease, Harman A, Byrne S, National Health and Medical Research Council (NHMRC)/Ideas Grant

2022

Human anogenital mononuclear phagocytes in tranmission of HIV, Harman A, National Health and Medical Research Council (NHMRC)/Ideas Grant

2021

Immune-to-brain signalling in CRPS: unravelling the detrimental relationship between inflammation and autonomic dysfunction, Austin P, Henderson L, Harman A, Australia New Zealand College of Anaesthetists (ANZCA)/Research Funding Scheme

2020

Targeting anogenital epidermal dendritic cells for pre-exposure prophyaxis, Harman A, Bertram K, Cunningham A, Australian Centre for HIV and Hepatitis Virology Research (ACH2)/Research Support

2019

Examining the interactions of HIV with its target cells in human anogenital tissues, Harman A, Haniffa M, National Health and Medical Research Council (NHMRC)/Ideas Grant

2018

Development of gene therapy vectors to reverse interferon inhibition by HIV in myeloid target cells, Cunningham A, Nasr N, Harman A, Kizana E, Australian Centre for HIV and Hepatitis Virology Research (ACH2)/Research Support
Defining pathways of epithelial spread of Herpes simplex virus after genital infection, Cunningham A, Harman A, Sandgren K, National Health and Medical Research Council (NHMRC)/Project Grants

2016

Restoring interferon production by myeloid cells infected with HIV by gene therapy, Nasr N, Cunningham A, Harman A, Diefenbach R, Kizana E, Australian Centre for HIV and Hepatitis Virology Research (ACH2)/Research Support

2015

Defining the Interaction of HIV with the Interferon System in Initial Mucosal Infection, Nasr N, Cunningham A, Palmer S, Harman A, Diefenbach R, Sandgren K, National Health and Medical Research Council (NHMRC)/Project Grants

2014

The Role of Dendritic Cells in Sexual Transmission of HIV and Viral Reservoir Formation, Harman A, Cunningham A, Palmer S, Kim M, Nasr N, National Health and Medical Research Council (NHMRC)/Project Grants

2013

The Role of Dendritic Cells in Sexual Transmission of HIV and viral rosend formation, Harman A, DVC Research/Bridging Support Grant
NanoString nCounter Platform, deFazio A, Alexander I, Booth D, Byrne J, Christodoulou J, Clarke C, Cunningham A, George J, Graham J, Harman A, Liddle C, Mann G, National Health and Medical Research Council (NHMRC)/Equipment Grant

2011

Cell type specific biologic responses to HIV infection, Cunningham A, Turville S, Harman A, Turville S, National Health and Medical Research Council (NHMRC)/Project Grants

In the media

https://www.abc.net.au/news/science/2018-05-24/three-scientists-talk-about-how-their-faith-fits-with-their-work/9543772

https://www.youtube.com/watch?v=HrdgdLKbFlI

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Professor Andrew Harman

Publications

By Type

By Year

Selected Grants

2023

2022

2021

2020

2019

2018

2016

2015

2014

2013

2011

In the media