2024

• Shrestha, R., Pickering, M., Ghesquière, B., Watt, M., Quek, L., Hoy, A., Tilley, W., Swinnen, J., Butler, L., Selth, L., et al (2024). ACSM1 and ACSM3 Regulate Fatty Acid Metabolism to Support Prostate Cancer Growth and Constrain Ferroptosis. Cancer Research, 84(14), 2313-2332. [More Information]
• Lin, H., Yang, X., Centenera, M., Huynh, K., Giles, C., Dehairs, J., Swinnen, J., Hoy, A., Meikle, P., Butler, L., Horvath, L., et al (2024). Circulating Lipid Profiles Associated with Resistance to Androgen Deprivation Therapy in Localized Prostate Cancer. JCO Precision Oncology, 8. [More Information]
• Scott, J., Quek, L., Hoy, A., Swinnen, J., Nassar, Z., Butler, L. (2024). Fatty acid elongation regulates mitochondrial β-oxidation and cell viability in prostate cancer by controlling malonyl-CoA levels. Biochemical and Biophysical Research Communications, 691, 149273-1-149273-7. [More Information]
• Mah, C., Don, A., Mills, I., Swinnen, J., Lynn, D., Nassar, Z., Butler, L., Nguyen, A., Niijima, T., Helm, M., Quek, L., Hoy, A., et al (2024). Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer. British Journal of Cancer, 130, 741-754. [More Information]

2023

• Solon-Biet, S., Clark, X., Bell-Anderson, K., Rusu, P., Perks, R., Freire, T., Pulpitel, T., Senior, A., Hoy, A., Aung, O., Le Couteur, D., Raubenheimer, D., Conigrave, A., Simpson, S., et al (2023). Toward reconciling the roles of FGF21 in protein appetite, sweet preference, and energy expenditure. Cell Reports, 42(12). [More Information]
• Dehairs, J., Quek, L., Hoy, A., Swinnen, J., et al (2023). Tracer Lipidomics. Mass Spectrometry for Lipidomics: Methods and Applications, (pp. 641-655). Weinheim, Germany: Wiley-V C H Verlag Gmbh. [More Information]

2022

• Jose, J., Hoque, M., Engel, J., Beevi, S., Wahba, M., Georgieva, M., Murphy, K., Hughes, W., Cochran, B., Lu, A., Hoy, A., Grewal, T., et al (2022). Annexin A6 and NPC1 regulate LDL-inducible cell migration and distribution of focal adhesions. Scientific Reports, 12(1), 596. [More Information]
• Zipinotti dos Santos, D., Santos Guimaraes, I., Hakeem-Sanni, M., Cochran, B., Rye, K., Grewal, T., Hoy, A., Rangel, L. (2022). Atorvastatin improves cisplatin sensitivity through modulation of cholesteryl ester homeostasis in breast cancer cells. Discover Oncology, 13(1). [More Information]
• Mak, B., Lin, H., Kwan, E., Fettke, H., Tran, B., Davis, I., Mahon, K., Stockler, M., Briscoe, K., Marx, G., Hoy, A., Horvath, L., et al (2022). Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer. BMC Medicine, 20(1), 112-1-112-14. [More Information]
• Quek, L., van Geldermalsen, M., Guan, Y., Wahi, K., Mayoh, C., Balaban, S., Pang, A., Wang, Q., Cowley, M., Brown, K., Hoy, A., et al (2022). Glutamine addiction promotes glucose oxidation in triple-negative breast cancer. Oncogene, 41(34), 4066-4078. [More Information]
• Nguyen, M., Jose, J., Wahba, M., Bernaus-Esqué, M., Hoy, A., Enrich, C., Rentero, C., Grewal, T. (2022). Linking Late Endosomal Cholesterol with Cancer Progression and Anticancer Drug Resistance. International Journal of Molecular Sciences, 23(13). [More Information]
• Mak, B., Lin, H., Duong, T., Mahon, K., Joshua, A., Stockler, M., Gurney, H., Parnis, F., Zhang, A., Scheinberg, T., Hoy, A., Horvath, L., et al (2022). Modulation of Plasma Lipidomic Profiles in Metastatic Castration-Resistant Prostate Cancer by Simvastatin. Cancers, 14(19). [More Information]

2021

• Gillis, J., Hinneh, J., Ryan, N., Irani, S., Moldovan, M., Quek, L., Shrestha, R., Hanson, A., Xie, J., Hoy, A., et al (2021). A feedback loop between the 1 androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth: Cooperativity between 6PGD and AR drives prostate cancer growth. eLife, 10, e62592 - 1-e62592 - 27. [More Information]
• Kwan, K., Burvenich, I., Centenera, M., Goh, Y., Rigopoulos, A., Dehairs, J., Swinnen, J., Raj, G., Hoy, A., Butler, L., et al (2021). Synthesis and fluorine-18 radiolabeling of a phospholipid as a PET imaging agent for prostate cancer. Nuclear Medicine and Biology, 93, 37-45. [More Information]
• Nagarajan, S., Butler, L., Hoy, A. (2021). The diversity and breadth of cancer cell fatty acid metabolism. Cancer and Metabolism, 9(1), 2. [More Information]
• Hoy, A., Nagarajan, S., Butler, L. (2021). Tumour fatty acid metabolism in the context of therapy resistance and obesity. Nature Reviews Cancer, 21(12), 753-766. [More Information]

2020

• Miladinovic, D., Cusick, T., Mahon, K., Haynes, A., Cortie, C., Meyer, B., Stricker, P., Wittert, G., Butler, L., Horvath, L., Hoy, A. (2020). Assessment of periprostatic and subcutaneous adipose tissue lipolysis and adipocyte size from men with localized prostate cancer. Cancers, 12(6), 1385. [More Information]
• Nassar, Z., Mah, C., Centenera, M., Irani, S., Sadowski, M., Scott, J., Nguyen, E., Nagarajan, S., Moldovan, M., Lynn, D., Hoy, A., et al (2020). Fatty Acid Oxidation Is an Adaptive Survival Pathway Induced in Prostate Tumors by HSP90 Inhibition. Molecular Cancer Research, 18(10), 1500-1511. [More Information]
• Nassar, Z., Mah, C., Dehairs, J., Burvenich, I., Irani, S., Centenera, M., Helm, M., Shrestha, R., Moldovan, M., Don, A., Horvath, L., Hoy, A., et al (2020). Human decr1 is an androgen-repressed survival factor that regulates pufa oxidation to protect prostate tumor cells from ferroptosis. eLife, 9, 1-34. [More Information]
• Krycer, J., Quek, L., Francis, D., Zadoorian, A., Weiss, F., Cooke, K., Nelson, M., Diaz Vegas, A., Humphrey, S., Scalzo, R., Varney, B., Nagarajan, S., Hoy, A., Cooney, G., Fazakerley, D., James, D., et al (2020). Insulin signaling requires glucose to promote lipid anabolism in adipocytes. Journal of Biological Chemistry, 295(38), 13250-13266. [More Information]
• Nerstedt, A., Kurhe, Y., Cansby, E., Caputo, M., Gao, L., Vorontsov, E., Ståhlman, M., Nuñez-Durán, E., Borén, J., Marschall, H., Hoy, A., et al (2020). Lipid Droplet-Associated Kinase STK25 Regulates Peroxisomal Activity and Metabolic Stress Response in Steatotic Liver. Journal of Lipid Research, 61(2), 178-191. [More Information]

2019

• Balaban, S., Nassar, Z., Zhang, A., Hosseini Beheshti, E., Centenera, M., Schreuder, M., Lin, H., Aishah, A., Varney, B., Liu-Fu, F., Lee, L., Nagarajan, S., Hardie, R., Raftopulos, N., Kakani, M., Holst, J., Horvath, L., Hoy, A., et al (2019). Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer. Molecular Cancer Research, 17(4), 949-962. [More Information]
• Nagarajan, S., Paul-Heng, M., Krycer, J., Fazakerley, D., Sharland, A., Hoy, A. (2019). Lipid and Glucose Metabolism in Hepatocyte Cell Lines and Primary Mouse Hepatocytes: A comprehensive resource for in vitro studies of hepatic metabolism. American Journal of Physiology - Endocrinology and Metabolism, 316(4), E578-E589. [More Information]

2018

• Cairns, R., Fischer, A., Blanco-Munoz, P., Alvarez-Guaita, A., Meneses-Salas, E., Egert, A., Buechler, C., Hoy, A., Heeren, J., Enrich, C., Grewal, T., et al (2018). Altered hepatic glucose homeostasis in AnxA6-KO mice fed a high-fat diet. PloS One, 13(8), 1-26. [More Information]
• Balaban, S., Lee, L., Varney, B., Aishah, A., Gao, Q., Shearer, R., Saunders, D., Grewal, T., Hoy, A. (2018). Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis. Molecular Oncology, 12(9), 1623-1638. [More Information]
• Attane, C., Milhas, D., Hoy, A., Muller, C. (2018). Metabolic remodeling induced by adipocytes: a new Achille heels in invasive breast cancer? Current Medicinal Chemistry, 25, 1-15. [More Information]
• Nassar, Z., Aref, A., Miladinovic, D., Mah, C., Raj, G., Hoy, A., Butler, L. (2018). Peri-prostatic adipose tissue: the metabolic microenvironment of prostate cancer. BJU International, 121(S3), 9-21. [More Information]
• Aref, A., Vincent, A., O'Callaghan, M., Martin, S., Sutherland, P., Hoy, A., Butler, L., Wittert, G. (2018). The inverse relationship between prostate specific antigen (PSA) and obesity. Endocrine-Related Cancer, 25(11), 933-941. [More Information]

2017

• Lin, H., Mahon, K., Weir, J., Mundra, P., Spielman, C., Briscoe, K., Gurney, H., Mallesara, G., Marx, G., Stockler, M., Hoy, A., Horvath, L., et al (2017). A distinct plasma lipid signature associated with poor prognosis in castration-resistant prostate cancer. International Journal of Cancer, 141(10), 2112-2120. [More Information]
• Balaban, S., Shearer, R., Lee, L., van Geldermalsen, M., Schreuder, M., Shtein, H., Cairns, R., Cooke, K., Fazakerley, D., Grewal, T., Holst, J., Hoy, A., et al (2017). Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer and Metabolism, 5(1). [More Information]
• Hoy, A., Balaban, S., Saunders, D. (2017). Adipocyte-Tumor Cell Metabolic Crosstalk in Breast Cancer. Trends in Molecular Medicine, 23(5), 381-392. [More Information]
• Nagarajan, S., Brandon, A., McKenna, J., Shtein, H., Nguyen, T., Suryana, E., Poronnik, P., Cooney, G., Saunders, D., Hoy, A. (2017). Insulin and diet-induced changes in the ubiquitin-modified proteome of rat liver. PloS One, 12(3), 1-14. [More Information]
• Hardie, R., van Dam, E., Cowley, M., Han, T., Balaban, S., Pajic, M., Pinese, M., Iconomou, M., Shearer, R., McKenna, J., Hoy, A., et al (2017). Mitochondrial mutations and metabolic adaptation in pancreatic cancer. Cancer and Metabolism, 5, 1-15. [More Information]
• Cairns, R., Alvarez-Guaita, A., Martínez-Saludes, I., Wason, S., Hanh, J., Nagarajan, S., Hosseini Beheshti, E., Monastyrskaya, K., Hoy, A., Buechler, C., Grewal, T., et al (2017). Role of hepatic Annexin A6 in fatty acid-induced lipid droplet formation. Experimental Cell Research, 358(2), 397-410. [More Information]

2016

• Meier, E., Rein-Fischboeck, L., Pohl, R., Wanninger, J., Hoy, A., Grewal, T., Eisinger, K., Krautbauer, S., Liebisch, G., Weiss, T., et al (2016). Annexin A6 protein is downregulated in human hepatocellular carcinoma. Molecular and Cellular Biochemistry, 418(1-2), 81-90. [More Information]

2015

• Meex, R., Hoy, A., Mason, R., Martin, S., McGee, S., Bruce, C., Watt, M. (2015). ATGL-mediated triglyceride turnover and the regulation of mitochondrial capacity in skeletal muscle. American Journal of Physiology - Endocrinology and Metabolism, 308(11), E960-E970. [More Information]
• Meex, R., Hoy, A., Morris, A., Brown, R., Lo, J., Burke, M., Goode, R., Kingwell, B., Kraakman, M., Febbraio, M., et al (2015). Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism. Cell Metabolism, 22(6), 1078-1089. [More Information]
• Gao, Q., Hanh, J., Varadi, L., Cairns, R., Sjoestroem, H., Liao, V., Wood, P., Balaban, S., Ong, J., Lin, H., Lai, F., Hoy, A., Grewal, T., Groundwater, P., Hibbs, D. (2015). Identification of dual PPARα/γ agonists and their effects on lipid metabolism. Bioorganic and Medicinal Chemistry, 23(24), 7676-7684. [More Information]
• Balaban, S., Lee, L., Schreuder, M., Hoy, A. (2015). Obesity and cancer progression: Is there a role of fatty acid metabolism? BioMed Research International, 2015, 1-7. [More Information]
• Wang, Q., Hardie, R., Hoy, A., van Geldermalsen, M., Gao, D., Fazli, L., Sadowski, M., Balaban, S., Schreuder, M., Nagarajah, R., Wong, J., Metierre, C., Pinello, N., Otte, N., Bailey, C., Ritchie, W., Rasko, J., Holst, J., et al (2015). Targeting ASCT2-Mediated Glutamine Uptake Blocks Prostate Cancer Growth and Tumour Development. Journal of Pathology, 236(3), 278-289. [More Information]
• Kamili, A., Roslan, N., Frost, S., Cantrill, L., Wang, D., Austin, D., Bright, R., Groblewski, G., Straub, B., Hoy, A., Chen, Y., Byrne, J. (2015). TPD52 expression increases neutral lipid storage within cultured cells. Journal of Cell Science, 128(17), 3223-3238. [More Information]

2014

• Briggs, D., Lockie, S., Benzler, J., Wu, Q., Stark, R., Reichenbach, A., Hoy, A., Lemus, M., Coleman, H., Parkington, H., et al (2014). Evidence That Diet-Induced Hyperleptinemia, but Not Hypothalamic Gliosis, Causes Ghrelin Resistance in NPY/AgRP Neurons of Male Mice. Endocrinology, 155(7), 2411-2422. [More Information]
• Abboud, M., Gordon-Thomson, C., Hoy, A., Balaban, S., Rybchyn, M., Cole, L., Su, Y., Brennan-Speranza, T., Fraser, D., Mason, R. (2014). Uptake of 25-Hydroxyvitamin D by muscle and fat cells. Journal of Steroid Biochemistry and Molecular Biology, 144(Part A), 232-236. [More Information]

2013

• Peoples, G., Hoy, A., Henry, R., McLennan, P. (2013). Autologous pump-perfused rat hind limb preparation for investigating muscle function and metabolism in vivo. Microcirculation, 20(6), 511-523. [More Information]
• Boon, J., Hoy, A., Stark, R., Brown, R., Meex, R., Henstridge, D., Schenk, S., Meikle, P., Horowitz, J., Kingwell, B., et al (2013). Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes, 62(2), 401-410. [More Information]
• Kim, M., Lee, K., Iseli, T., Hoy, A., George, J., Grewal, T., Roufogalis, B. (2013). Compound K modulates fatty acid-induced lipid droplet formation and expression of proteins involved in lipid metabolism in hepatocytes. Liver International, 33(10), 1583-1593. [More Information]
• Bell-Anderson, K., Funnell, A., Williams, H., Jusoh, H., Scully, T., Lim, W., Burdach, J., Mak, K., Knights, A., Hoy, A., Nicholas, H., Salis (nee Sainsbury), A., et al (2013). Loss of Kruppel-Like Factor 3 (KLF3/BKLF) Leads to Upregulation of the Insulin-Sensitizing Factor Adipolin (FAM132A/CTRP12/C1qdc2). Diabetes, 62(8), 2728-2737. [More Information]

2012

• Watt, M., Hoy, A., Muoio, D., Coleman, R. (2012). Distinct roles of specific fatty acids in cellular processes: implications for interpreting and reporting experiments. American Journal of Physiology - Endocrinology and Metabolism, 302(1), E1-E3. [More Information]
• Watt, M., Hoy, A. (2012). Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function. American Journal of Physiology - Endocrinology and Metabolism, 302(11), e1315-e1328. [More Information]
• Watt, M., Barnett, A., Bruce, C., Schenk, S., Horowitz, J., Hoy, A. (2012). Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide. Diabetologia, 55(10), 2741-2746. [More Information]

2011

• Turpin, S., Hoy, A., Brown, R., Rudaz, C., Honeyman, J., Matzaris, M., Watt, M. (2011). Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice. Diabetologia, 54(1), 146-156. [More Information]
• Hoy, A., Bruce, C., Turpin, S., Morris, A., Febbraio, M., Watt, M. (2011). Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation. Endocrinology, 152(1), 48-58. [More Information]
• Wright, L., Brandon, A., Hoy, A., Forsberg, G., Lelliott, C., Reznick, J., Löfgren, L., Oscarsson, J., Strömstedt, M., Cooney, G., et al (2011). Amelioration of lipid-induced insulin resistance in rat skeletal muscle by overexpression of Pgc-1(beta) involves reductions in long-chain acyl-CoA levels and oxidative stress. Diabetologia, 54(6), 1417-1426. [More Information]
• Brandon, A., Hoy, A., Wright, L., Turner, N., Hegarty, B., Iseli, T., Xu, J., Cooney, G., Saha, A., Ruderman, N., et al (2011). The evolution of insulin resistance in muscle of the glucose infused rat. Archives of Biochemistry and Biophysics, 509(2), 133-141. [More Information]

2010

• Hoehn, K., Turner, N., Swarbrick, M., Wilks, D., Preston, E., Phua, Y., Hoy, A., James, D., Cooney, G., et al (2010). Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metabolism, 11(1), 70-76. [More Information]

2009

• Hoehn, K., Salmon, A., Hohnen-Behrens, C., Turner, N., Hoy, A., Maghzal, G., Stocker, R., Van Remmen, H., Kraegen, E., Cooney, G., et al (2009). Insulin resistance is a cellular antioxidant defense mechanism. Proceedings of the National Academy of Sciences of the United States of America, 106(42), 17787-17792. [More Information]
• Hoy, A., Brandon, A., Turner, N., Watt, M., Bruce, C., Cooney, G., Kraegen, E. (2009). Lipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylation. American Journal of Physiology - Endocrinology and Metabolism, 297(1), E67-E75. [More Information]
• Hoy, A., Watt, M. (2009). Lipid Partitioning and Insulin Sensitivity: Lessons learntfrom Genetic Models. Asia-Pacific Journal of Endocrinology (APJOE), 1(1), 35-47.
• Bruce, C., Hoy, A., Turner, N., Watt, M., Allen, T., Carpenter, K., Cooney, G., Febbraio, M., Kraegen, E. (2009). Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance. Diabetes, 58(3), 550-558. [More Information]
• Hoy, A., Peoples, G., McLennan, P. (2009). The effect of vasoconstrictors on oxygen consumption in resting and contracting skeletal muscle of the autologous pump-perfused rat hindlimb. Journal of Physiology and Pharmacology, 60(3), 155-160. [More Information]

2008

• Hoy, A., Turner, N. (2008). New insight into the mechanism by which acute physical exercise ameliorates insulin resistance. Journal of Physiology, 586(9), 2251-2252. [More Information]

2007

• Hoy, A., Bruce, C., Cederberg, A., Turner, N., James, D., Cooney, G., Kraegen, E. (2007). Glucose infusion causes insulin resistance in skeletal muscle of rats without changes in Akt and AS160 phosphorylation. American Journal of Physiology - Endocrinology and Metabolism, 293(5), e1358-e1364. [More Information]

2006

• Kraegen, E., Saha, A., Preston, E., Wilks, D., Hoy, A., Cooney, G., Ruderman, N. (2006). Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. American Journal of Physiology - Endocrinology and Metabolism, 290, e471-e479. [More Information]
• Ye, J., Dzamko, N., Hoy, A., Iglesias, M., Kemp, B., Kraegen, E. (2006). Rosiglitazone treatment enhances acute AMP-activated protein kinase-mediated muscle and adipose tissue glucose uptake in high-fat-fed rats. Diabetes, 55(10), 2797-2804. [More Information]