Dr Anthony Cutrupi
ANZAC Research Institute
School of Medical Sciences
Faculty of Medicine and Health
Anthony Cutrupi is a Reserach Fellow/Adjunct Lecturer in the School of Medical Sciences and leads the Motor Neuron Diseases Cell Biology and Stem Cell Research Program at the Northcott Neuroscience Laboratory, ANZAC Research Institute
Anthony's work has focused on generating and studying iPSC-derived neuronal models of inherited motor neuron diseases and peripheral neuropathies to better understand the pathobiology and disease mechanisms driving degeneration of motor neurons. Anthony has a particular interest in how aging contributes to the onset and pathogenesis of late-onset neurodegenerative diseases such as amyotrophic lateral sclerosis. We are currently exploring novel strategies to induce aging in iPSC-derived neurons to generate pre-clinical models that will allow us to understand disease progression and the pathobiological changes occuring in motor neurons from presymptomatic through to end-stage disease.
Member: International Society of Stem Cell Research (ISSCR)
Member: Australasian Society of Stem Cell Research (ASSCR)
Member: Peripheral Nerve Society (PNS)
Kids Cancer Alliance Award for Best Poster Presentation (Post Graduate Category): Australian Society of Medical Reserach (ASMR) NSW Meeting, 2016
Australian Society of Stem Cell Research/ National Stem Cell Foundation Travel Award, 2018
Griffith-Hack Innovation Award (Postgraduate Category): ANZAC, CRGH and Griffith-Hack Committee, 2019
Best Platform Talk (Postdoctoral Category): Australasian Society for Stem Cell Reserach (ASSCR) NSW Symposium, 2021
Johnathan Pembroke Prize: Peripheral Nerve Society (PNS) Meeting, 2022
Sydney Research Big Idea (finalist): Concord Clinical Week, Sydney Reserach, 2022
Annual Health Infrastructure Award: Sydney Innovation Week, Sydney Local Health District, 2023
Vocational Excellence Award (Medical and Human Services): Rotary Club of Strathfield, 2023
Best Oral Presentation (Basic Science Category): Pan-Asian Consortium for Treatment and Research in ALS, 2023
Publications
Journals
- Van Lent, J., Judge, L., Conklin, B., Tyynismaa, H., Clark, A., Bennett, D., Van Den Bosch, L., Saporta, M., Timmerman, V., Prior, R., Perez-Siles, G., Cutrupi, A., Kennerson, M., et al (2024). Advances and challenges in modeling inherited peripheral neuropathies using iPSCs. Experimental and Molecular Medicine, 56(6), 1348-1364. [More Information]
- Cutrupi, A., Narayanan, R., Perez-Siles, G., Grosz, B., Lai, K., Boyling, A., Ellis, M., Lin, R., Neumann, B., Mao, D., Nicholson, G., Vucic, S., Kennerson, M., et al (2023). Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy. Brain, 146(3), 880-897. [More Information]
- Perez-Siles, G., Cutrupi, A., Ellis, M., Screnci, R., Mao, D., Uesugi, M., Yiu, E., Ryan, M., Choi, B., Nicholson, G., Kennerson, M. (2020). Energy metabolism and mitochondrial defects in X-linked Charcot-Marie-Tooth (CMTX6) iPSC-derived motor neurons with the p.R158H PDK3 mutation. Scientific Reports, 10(1), 9262. [More Information]
2024
- Van Lent, J., Judge, L., Conklin, B., Tyynismaa, H., Clark, A., Bennett, D., Van Den Bosch, L., Saporta, M., Timmerman, V., Prior, R., Perez-Siles, G., Cutrupi, A., Kennerson, M., et al (2024). Advances and challenges in modeling inherited peripheral neuropathies using iPSCs. Experimental and Molecular Medicine, 56(6), 1348-1364. [More Information]
2023
- Cutrupi, A., Narayanan, R., Perez-Siles, G., Grosz, B., Lai, K., Boyling, A., Ellis, M., Lin, R., Neumann, B., Mao, D., Nicholson, G., Vucic, S., Kennerson, M., et al (2023). Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy. Brain, 146(3), 880-897. [More Information]
2020
- Perez-Siles, G., Cutrupi, A., Ellis, M., Screnci, R., Mao, D., Uesugi, M., Yiu, E., Ryan, M., Choi, B., Nicholson, G., Kennerson, M. (2020). Energy metabolism and mitochondrial defects in X-linked Charcot-Marie-Tooth (CMTX6) iPSC-derived motor neurons with the p.R158H PDK3 mutation. Scientific Reports, 10(1), 9262. [More Information]
- Perez-Siles, G., Cutrupi, A., Ellis, M., Kuriakose, J., La Fontaine, S., Mao, D., Uesugi, M., Takata, R., Speck-Martins, C., Nicholson, G., Kennerson, M. (2020). Modelling the pathogenesis of X-linked distal hereditary motor neuropathy using patient-derived iPSCs. Disease Models & Mechanisms, 13(2), dmm041541. [More Information]
2018
- Cutrupi, A., Brewer, M., Nicholson, G., Kennerson, M. (2018). Structural variations causing inherited peripheral neuropathies: A paradigm for understanding genomic organization, chromatin interactions, and gene dysregulation. Molecular Genetics & Genomic Medicine, 6(3), 422-433. [More Information]
2016
- Drew, A., Cutrupi, A., Brewer, M., Nicholson, G., Kennerson, M. (2016). A 1.35A Mb DNA fragment is inserted into the DHMN1 locus on chromosome 7q34-q36.2. Human Genetics, 135(11), 1269-1278. [More Information]
In the media
“Research Excellence recognized at Sydney Innovation Week” (16 August 2023)
“ANZAC Research Institute celebrates milestone” (23 November 2022)
"Advances welcomed in stem cell technology” ANZAC Research Institute Discovery Newsletter (Issue 20, January 2018)
“Kids Cancer Alliance Award for PhD Student” ANZAC Research Institute Discovery Newsletter (Issue 17, July 2016)