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Associate Professor Belinda Gray

BSc(Med) MBBS PhD FRACP FCSANZ FHRS

Heart Foundation Future Leader Fellow Central Clinical School
Cardiologist and Director of Sports Cardiology Program Royal Prince Alfred Hospital
Associate Professor, Central Clinical School
Faculty of Medicine and Health

Phone

+61 2 9565 6295

Email

belinda.gray@sydney.edu.au

Biographical details

A/Prof Belinda Gray is a Heart Foundation Future Leadership Fellow at Central Clinical School. She is also a Consultant Cardiologist with a special interest in sports cardiology and genetic heart diseases at Royal Prince Alfred Hospital (RPAH). She completed a Heart Foundation-funded PhD at the University of Sydney from 2013-2016 in genetic heart disease before completing a 2 year NHMRC overseas fellowship in Inherited Cardiac Conditions and Sports Cardiology at St George’s, London, UK. She developed NSW first dedicated sports cardiology clinic and research program at RPAH in 2021. She is a level 3 cardiac MRI reporter. Her research focusses on prevention of sudden cardiac death in the young, including young athletes.

Research interests

Sports Cardiology

Sudden Cardiac Death in the young

Genetic heart disease

Cardiomyopathy

Channelopathy

Cardiac MRI

Teaching and supervision

Genetic Heart Disease

Sports Cardiology

Cardiomyopathy

Sudden Cardiac Death in the Young

Current projects

Project title	Summary of project
Improving our understanding of Genetic Heart Disease	This project aims to longitudinally follow patients with genetic heart disease, with an aim to improve our understanding of the specific clinical features and risk markers for individuals and families with these conditions.Ultimately we aim to improve our risk stratification reduce sudden cardiac death for patients and families with a genetic heart disease.
Improving Our Understanding of Athlete’s Heart	This project aims to better understand differences between ‘athlete’s heart’ and underlying heart muscle disease (cardiomyopathy) using proteomics, metabolomics and genomics.This study is in collaboration with the Precision Medicine Laboratory at Charles Perkins Centre with A/Prof Sean Lal and Professor John O’Sullivan.
Outcomes Registry for Cardiac Conditions in Athletes: Prospective, Multisite Research Study (The ORCCA Study)	The ORCCA Study is an international registry of young competitive athletes with a cardiac condition or suspected cardiac condition. The primary aim of the study is to assess long-term cardiovascular outcomes. Key secondary aims include an assessment of disease progression, physical activity levels, the psychosocial impacts of a cardiac diagnosis and sport eligibility decision-making. This study is in collaboration with University of Washington.
Understanding the Anatomical Basis to ECG Changes in Female Athletes	This study aims to use cardiac magnetic resonance imaging to investigate the potential underlying mechanisms for ECG changes noted in female endurance athletes.This study is in collaboration with Victor Chang Cardiac Research Institute.
Novel Methods of Risk Assessment for Patients with the Brugada Syndrome: Rare Arrhythmia Syndrome Evaluation (RASE) Brugada Study	This international, multi-centre study aims to develop a new ECG-based method of risk stratification for individuals with Brugada syndrome. The study aims to develop an ECG-based risk score using machine learning. This study is in collaboration with St George’s University of London.

Associations

Chair, Cardiac Society of Australia and New Zealand (CSANZ) Genetic Council

Awards and honours

2024 Heart Foundation Future Leader Fellowship

2020 University of Sydney, Cardiovascular Initiative Catalyst Award

2019 European Heart Rhythm Association (EHRA) Educational Grant

2018 Heart Rhythm Society USA, Travelling Fellowship

2017 CSANZ Travelling Fellowship, European Society of Cardiology, Barcelona

2016 Heart Rhythm Society Annual Scientific Sessions, San Francisco, USA, Young Investigator Awards, Finalist

2016 CSANZ Annual Scientific Sessions; Ralph Reader Prize, Finalist

2016 Cardiac Society of Australia and New Zealand Travelling Fellowship

2016 Centenary Institute Travel Award

2016 Heart Foundation Australia Collaboration and Exchange Award

2016 SADS Foundation Courts K. Cleveland, Jn. USA; Finalist Young Investigator Awards in Cardiac Channelopathy Research

2013 Royal Australasian College of Physicians Trainee Research Awards, Finalist

2013 Royal Prince Alfred Hospital Patrons Prize Finalist

2012 Royal Prince Alfred Hospital Patrons Prize Finalist

2011 CSANZ Travelling Fellowship, American Heart Association, Orlando, USA

Qualifications

2022 Fellowship of Heart Rhythm Society USA (FHRS)

2020 Fellowship of the Cardiac Society of Australia and New Zealand (FCSANZ)

2019 Level 3 CMR Certification: Society for Cardiovascular Magnetic Resonance (SCMR)

2019 Postdoctoral fellowship in Sports Cardiology, Inherited Cardiac Conditions and Cardiac MRI. St George’s University of London

Themes

Obesity, Diabetes and Cardiovascular Disease

Keywords

Cardiovascular diseases, Genetics

(St George's University of London) Research Collaboration and Cross-institutional teaching in MSc Sports Cardiology with Prof Michael Papadakis and Prof Elijah Behr

United States

(Yale University) Collaboration on the LIVE-HCM and LIVE-LQTS Studies with Dr R Lampert and team

Current research students

Project title	Research student
Phenotypic differences between athletes and individuals with dilated cardiomyopathy	Rita-maria ABDO
Using genomics to advance sudden cardiac death diagnosis and risk assessment.	Yuchen Chang CHANG
Understanding the athlete heart and the role of gender and ethnic diversity	Angus DAVIS

Publications

By Type

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Journals

Lampert, R., Harmon, K., James, C., Kim, J., Krahn, A., La Gerche, A., Link, M., MacIntyre, C., Mont, L., Salerno, J., Gray, B., et al (2024). 2024 HRS expert consensus statement on arrhythmias in the athlete: Evaluation, treatment, and return to play. Heart Rhythm. [More Information]
Davis, A., Orchard, J., McGhie, J., Broadbridge, D., Raju, H., La Gerche, A., Puranik, R., Gray, B., De Jongh, J., Driscoll, T., Orchard, J. (2024). Comparison of 6-lead smartphone ECG and 12-lead ECG in athletes and a genetic heart disease population. Expert Review of Medical Devices. [More Information]
McColl, H., Cordina, R., Lal, S., Parker, M., Hunyor, I., Medi, C., Gray, B. (2024). Recurrent immunosuppressive-responsive myocarditis in a patient with desmoplakin cardio-myopathy: a case report. European Heart Journal - Case Reports, 8(3), ytae129. [More Information]
Davis, A., Driscoll, T., Orchard, J., Raju, H., Gray, B., Orchard, J. (2024). Relative utility of portable ECG devices in capturing arrhythmias in athletes. Expert Review of Medical Devices, 21(12), 1179-1188. [More Information]
Hespe, S., Gray, B., Puranik, R., Peters, S., Sweeting, J., Ingles, J. (2024). The role of genetic testing in management and prognosis of individuals with inherited cardiomyopathies. Trends In Cardiovascular Medicine. [More Information]
Ensam, B., Sharma, S., Papadakis, M., Devine, B., MacFarlane, P., Behr, E., Scrocco, C., Johnson, D., Wijeyeratne, Y., Bastiaenen, R., Gray, B., et al (2024). Type 1 Brugada Pattern May Be Provoked by Ajmaline in Some Healthy Subjects: Results From a Clinical Trial. Circulation, 149(21), 1693-1695. [More Information]
Gray, B., Ackerman, M., Link, M., Lampert, R. (2024). Vigorous exercise and sports participation in individuals with hypertrophic cardiomyopathy. Trends In Cardiovascular Medicine. [More Information]
Lampert, R., Barth, C., Behr, E., Bell, C., Berul, C., Bos, J., Bradley, D., Cannom, D., Cannon, B., Concannon, M., Gray, B., et al (2024). Vigorous Exercise in Patients with Congenital Long-QT Syndrome: Results of the Prospective, Observational, Multinational LIVE-LQTS Study. Circulation. [More Information]
Isbister, J., Gray, B., Offen, S., Yeates, L., Naoum, C., Medi, C., Raju, H., Semsarian, C., Puranik, R., Sy, R. (2023). Longitudinal assessment of structural phenotype in Brugada syndrome using cardiac magnetic resonance imaging. Heart Rhythm O2, 4(1), 34-41. [More Information]
Leslie, F., Avis, S., Bagnall, R., Bendall, J., Briffa, T., Brouwer, I., Butters, A., Figtree, G., La Gerche, A., Gray, B., Semsarian, C., Sy, R., Yeates, L., et al (2023). The New South Wales Sudden Cardiac Arrest Registry: A Data Linkage Cohort Study. Heart, Lung, and Circulation, 32(9), 1069-1075. [More Information]
Hoorntje, E., Burns, C., Marsili, L., Corden, B., Parikh, V., Te Meerman, G., Gray, B., Adiyaman, A., Bagnall, R., Barge-Schaapveld, D., et al (2023). Variant Location Is a Novel Risk Factor for Individuals with Arrhythmogenic Cardiomyopathy Due to a Desmoplakin (DSP) Truncating Variant. Circulation. Genomic and Precision Medicine, 16(1), E003672. [More Information]
Lampert, R., Ackerman, M., Marino, B., Burg, M., Ainsworth, B., Salberg, L., Tome Esteban, M., Ho, C., Abraham, R., Balaji, S., Gray, B., et al (2023). Vigorous Exercise in Patients with Hypertrophic Cardiomyopathy. JAMA Cardiology, 8(6), 595-605. [More Information]
Vivekanandam, V., Männikkö, R., Skorupinska, I., Germain, L., Gray, B., Wedderburn, S., Kozyra, D., Sud, R., James, N., Holmes, S., et al (2022). Andersen-Tawil syndrome: deep phenotyping reveals significant cardiac and neuromuscular morbidity. Brain, 145(6), 2108-2120. [More Information]
Semsarian, C., Gray, B., Haugaa, K., Lampert, R., Sharma, S., Kovacic, J. (2022). Athletic Activity for Patients With Hypertrophic Cardiomyopathy and Other Inherited Cardiovascular Diseases: JACC Focus Seminar 3/4. Journal of the American College of Cardiology, 80(13), 1268-1283. [More Information]
Castelletti, S., Gray, B., Basso, C., Behr, E., Crotti, L., Elliott, P., Gonzalez Corcia, C., D'Ascenzi, F., Ingles, J., Loeys, B., et al (2022). Indications and utility of cardiac genetic testing in athletes. European Journal of Preventive Cardiology, 29(12), 1582-1591. [More Information]
Gray, B., Baruteau, A., Antolin, A., Pittman, A., Sarganas, G., Molokhia, M., Blom, M., Bastiaenen, R., Bardai, A., Priori, S., et al (2022). Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome. Circulation. Genomic and Precision Medicine, 15(1), E003391. [More Information]
Stafford, F., Krishnan, N., Richardson, E., Butters, A., Hespe, S., Burns, C., Gray, B., Medi, C., Nowak, N., Isbister, J., Richmond, D., Singer, E., Sy, R., Yeates, L., Bagnall, R., Semsarian, C., Ingles, J., et al (2022). The role of genetic testing in diagnosis and care of inherited cardiac conditions in a specialised multidisciplinary clinic. Genome Medicine, 14(1). [More Information]
Isbister, J., Nowak, N., Butters, A., Yeates, L., Gray, B., Sy, R., Ingles, J., Bagnall, R., Semsarian, C. (2021). "Concealed cardiomyopathy" as a cause of previously unexplained sudden cardiac arrest. International Journal of Cardiology, 324, 96-101. [More Information]
Miles, C., Asimaki, A., Ster, I., Papadakis, M., Gray, B., Westaby, J., Finocchiaro, G., Bueno-Beti, C., Ensam, B., Basu, J., et al (2021). Biventricular Myocardial Fibrosis and Sudden Death in Patients With Brugada Syndrome. Journal of the American College of Cardiology, 78(15), 1511-1521. [More Information]
Femia, J., Langlois, N., Raleigh, J., Gray, B., Othman, F., Perumal, S., Semsarian, C., Puranik, R. (2021). Comparison of conventional autopsy with post-mortem magnetic resonance, computed tomography in determining the cause of unexplained death. Forensic Science, Medicine, and Pathology, 17(1), 10-18. [More Information]
Milman, A., Behr, E., Gray, B., Johnson, D., Andorin, A., Hochstadt, A., Gourraud, J., Maeda, S., Takahashi, Y., Jm Juang, J., et al (2021). Genotype-Phenotype Correlation of SCN5A Genotype in Patients With Brugada Syndrome and Arrhythmic Events: Insights From the SABRUS in 392 Probands. Circulation. Genomic and Precision Medicine, 14(5), E003222. [More Information]
Malhotra, A., Dhutia, H., Yeo, T., Finocchiaro, G., Gati, S., Bulleros, P., Fanton, Z., Papatheodorou, E., Miles, C., Basu, J., et al (2020). Accuracy of the 2017 international recommendations for clinicians who interpret adolescent athletes' ECGs: A cohort study of 11 168 British white and black soccer players. British Journal of Sports Medicine, 54(12), 739-745. [More Information]
Finocchiaro, G., Dhutia, H., Gray, B., Ensam, B., Papatheodorou, S., Miles, C., Malhotra, A., Fanton, Z., Bulleros, P., Homfray, T., et al (2020). Diagnostic yield of hypertrophic cardiomyopathy in first-degree relatives of decedents with idiopathic left ventricular hypertrophy. Europace, 22(4), 632-642. [More Information]
Gray, B., Semsarian, C. (2020). Genetic Testing for Inherited Cardiovascular Disease: Implications of the AHA Scientific Statement for Cardiologists. Heart, Lung, and Circulation, 29(11), 1581-1584. [More Information]
Gray, B., Semsarian, C., Fatkin, D., Ingles, J., Atherton, J., Davis, A., Sanders, P., Pachter, N., Skinner, J., Stiles, M. (2020). Patients With Genetic Heart Disease and COVID-19: A Cardiac Society of Australia and New Zealand (CSANZ) Consensus Statement. Heart, Lung, and Circulation, 29(7), e85-e87. [More Information]
Clemens, D., Gray, B., Bagnall, R., Tester, D., Giudicessi, J., Maleszewski, J., Crotti, L., Schwartz, P., Matthews, E., Semsarian, C., et al (2020). Prevalence and Phenotypic Correlations of Calmodulinopathy-Causative CALM1-3 Variants Detected in a Multicenter Molecular Autopsy Cohort of Sudden Unexplained Death Victims. Circulation. Genomic and Precision Medicine, 13(6), 716-718. [More Information]
Clemens, D., Gray, B., Bagnall, R., Tester, D., Dotzler, S., Giudicessi, J., Matthews, E., Semsarian, C., Behr, E., Ackerman, M. (2020). Triadin Knockout Syndrome is Absent in a Multi-Center Molecular Autopsy Cohort of Sudden Infant Death Syndrome and Sudden Unexplained Death in the Young and is Extremely Rare in the General Population. Circulation. Genomic and Precision Medicine, 13(2), 52-58. [More Information]
Gray, B., Semsarian, C. (2020). Utility of genetic testing in athletes. Clinical Cardiology, 43(8), 915-920. [More Information]
Semsarian, C., Orchard, J., Gray, B., Orchard, J. (2020). When do athletes benefit from cardiac genetic testing? British Journal of Sports Medicine, 54(15), 939-940. [More Information]
Yeates, L., Ingles, J., Gray, B., Singarayar, S., Sy, R., Semsarian, C., Bagnall, R. (2019). A balanced translocation disrupting SCN5A in a family with Brugada syndrome and sudden cardiac death. Heart Rhythm, 16(2), 231-238. [More Information]
Gray, B., Ackerman, M., Semsarian, C., Behr, E. (2019). Evaluation After Sudden Death in the Young. Circulation. Arrhythmia and Electrophysiology, 12(8), 1-9. [More Information]
Gray, B., Tester, D., Wong, L., Chanana, P., Jaye, A., Evans, J., Baruteau, A., Evans, M., Fleming, P., Jeffrey, I., et al (2019). Noncardiac genetic predisposition in sudden infant death syndrome. Genetics in Medicine, 21(3), 641-649. [More Information]
Miles, C., Finocchiaro, G., Papadakis, M., Gray, B., Westaby, J., Ensam, B., Basu, J., Parry-Williams, G., Papatheodorou, E., Paterson, C., et al (2019). Sudden Death and Left Ventricular Involvement in Arrhythmogenic Cardiomyopathy. Circulation, 139(15), 1786-1797. [More Information]
Gray, B., Semsarian, C. (2018). Editorial commentary: Will the real long QT genes please stand up. Trends In Cardiovascular Medicine, 28(7), 465-466. [More Information]
Tester, D., Wong, L., Chanana, P., Gray, B., Jaye, A., Evans, J., Evans, M., Fleming, P., Jeffrey, I., Cohen, M., et al (2018). Exome-Wide Rare Variant Analyses in Sudden Infant Death Syndrome. The Journal of Pediatrics, 203, 423-428. [More Information]
Gray, B., Hasdemir, C., Ingles, J., Aiba, T., Makita, N., Probst, V., Wilde, A., Newbury-Ecob, R., Sheppard, M., Semsarian, C., Sy, R., et al (2018). Lack of genotype-phenotype correlation in Brugada Syndrome and Sudden Arrhythmic Death Syndrome families with reported pathogenic SCN1B variants. Heart Rhythm, 15(7), 1051-1057. [More Information]
Gray, B., Gnanappa, G., Bagnall, R., Femia, G., Yeates, L., Ingles, J., Burns, C., Puranik, R., Grieve, S., Semsarian, C., Sy, R. (2018). Relations between right ventricular morphology and clinical, electrical and genetic parameters in Brugada Syndrome. PloS One, 13(4), 1-14. [More Information]
Papadakis, M., Papatheodorou, E., Mellor, G., Raju, H., Bastiaenen, R., Wijeyeratne, Y., Wasim, S., Ensam, B., Finocchiaro, G., Gray, B., et al (2018). The Diagnostic Yield of Brugada Syndrome After Sudden Death With A Normal Autopsy. Journal of the American College of Cardiology, 71(11), 1204-1214. [More Information]
Gray, B., Ingles, J., Medi, C., Driscoll, T., Semsarian, C. (2017). Cardiovascular Effects of Energy Drinks in Familial Long QT Syndrome: A Randomized Cross-Over Study. International Journal of Cardiology, 231, 150-154. [More Information]
Gray, B., Kirby, A., Kabunga, P., Freedman, S., Yeates, L., Kanthan, A., Medi, C., Keech, A., Semsarian, C., Sy, R. (2017). Twelve-lead ambulatory electrocardiographic monitoring in Brugada syndrome: Potential diagnostic and prognostic implications. Heart Rhythm, 14(6), 866-874. [More Information]
Gray, B., Bagnall, R., Lam, L., Ingles, J., Turner, C., Haan, E., Davis, A., Yang, P., Clancy, C., Sy, R., Semsarian, C. (2016). A novel heterozygous mutation in cardiac calsequestrin causes autosomal dominant catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm, 13(8), 1652-1660. [More Information]
Burns, C., Ingles, J., Davis, A., Connell, V., Gray, B., Hunt, L., McGaughran, J., Semsarian, C. (2016). Clinical and genetic features of Australian families with long QT syndrome: A registry-based study. Journal of Arrhythmia, 32(6), 456-461. [More Information]
Gray, B., Klimis, H., Inam, S., Ariyathna, N., Kumar, S., Bailey, B., Patel, S. (2016). Corrigendum to 'Radiation Exposure During Cardiac Catheterisation is Similar for Both Femoral and Radial Approaches' Heart, Lung and Circulation (2015) 24, 264-269. Heart, Lung, and Circulation, 25(10), 1043. [More Information]
Gray, B., Behr, E. (2016). New Insights into the Genetic Basis of Inherited Arrhythmia Syndromes. Circulation: Cardiovascular Genetics, 9(6), 569-577. [More Information]
Earle, N., Ingles, J., Bagnall, R., Gray, B., Crawford, J., Smith, W., Shelling, A., Love, D., Semsarian, C., Skinner, J. (2015). NOS1AP polymorphisms modify QTc interval duration but not cardiac arrest risk in hypertrophic cardiomyopathy. Journal of Cardiovascular Electrophysiology, 26(12), 1346-1351. [More Information]
Gray, B., Klimis, H., Inam, S., Ariyathna, N., Kumar, S., Bailey, B., Patel, S. (2015). Radiation Exposure During Cardiac Catheterisation is Similar for Both Femoral and Radial Approaches. Heart, Lung, and Circulation, 24(3), 264-269. [More Information]
Ingles, J., Johnson, R., Sarina, T., Yeates, L., Burns, C., Gray, B., Ball, K., Semsarian, C. (2015). Social determinants of health in the setting of hypertrophic cardiomyopathy. International Journal of Cardiology, 184(1), 743-749. [More Information]
Gray, B., Semsarian, C., Sy, R. (2014). Brugada Syndrome: A Heterogeneous Disease with a Common ECG Phenotype? Journal of Cardiovascular Electrophysiology, 25(4), 450-456. [More Information]
Puranik, R., Gray, B., Lackey, H., Yeates, L., Parker, G., Duflou, J., Semsarian, C. (2014). Comparison of conventional autopsy and magnetic resonance imaging in determining the cause of sudden death in the young. Journal of Cardiovascular Magnetic Resonance, 16(1), 1-11. [More Information]
Gray, B., McGuire, M., Semsarian, C., Medi, C. (2014). Late positive flecainide challenge test for Brugada syndrome. Heart Rhythm, 11(5), 898-900. [More Information]
Gray, B., Spies, J., Ng, M. (2014). Severe hypertensive encephalopathy following percutaneous balloon aortic valvuloplasty for aortic stenosis. International Journal of Cardiology, 171(3), e63-e64. [More Information]
Yu, Y., Gray, B., Lowe, H., Halmagyi, G., Ng, M. (2013). Dual modality intravascular imaging of unstable, symptomatic but "hemodynamically insignificant" carotid stenosis. Journal of Neurology, 260(7), 1934-1935. [More Information]
Gray, B., Yeates, L., Medi, C., Ingles, J., Semsarian, C. (2013). Homozygous mutation in the cardiac troponin I gene: Clinical heterogeneity in hypertrophic cardiomyopathy. International Journal of Cardiology, 168(2), 1530-1531. [More Information]
Gray, B., Ingles, J., Medi, C., Semsarian, C. (2013). Prolongation of the QTc Interval Predicts Appropriate Implantable Cardioverter-Defibrillator Therapies in Hypertrophic Cardiomyopathy. JACC: Heart Failure, 1(2), 149-155. [More Information]
Gray, B., Das K, J., Semsarian, C. (2012). Consumption of energy drinks: A new provocation test for primary arrhythmogenic diseases? International Journal of Cardiology, 159(1), 77-78. [More Information]
Gray, B., Ingles, J., Semsarian, C. (2011). Natural history of genotype positive-phenotype negative patients with hypertrophic cardiomyopathy. International Journal of Cardiology, 152(2), 258-259. [More Information]
Gray, B., MacDonald, P., Kuchar, D. (2011). Reversal of cardiomyopathy with ivabradine. Internal Medicine Journal, 41(2), 213-214. [More Information]

show 54 more

By Year

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2024

Lampert, R., Harmon, K., James, C., Kim, J., Krahn, A., La Gerche, A., Link, M., MacIntyre, C., Mont, L., Salerno, J., Gray, B., et al (2024). 2024 HRS expert consensus statement on arrhythmias in the athlete: Evaluation, treatment, and return to play. Heart Rhythm. [More Information]
Davis, A., Orchard, J., McGhie, J., Broadbridge, D., Raju, H., La Gerche, A., Puranik, R., Gray, B., De Jongh, J., Driscoll, T., Orchard, J. (2024). Comparison of 6-lead smartphone ECG and 12-lead ECG in athletes and a genetic heart disease population. Expert Review of Medical Devices. [More Information]
McColl, H., Cordina, R., Lal, S., Parker, M., Hunyor, I., Medi, C., Gray, B. (2024). Recurrent immunosuppressive-responsive myocarditis in a patient with desmoplakin cardio-myopathy: a case report. European Heart Journal - Case Reports, 8(3), ytae129. [More Information]
Davis, A., Driscoll, T., Orchard, J., Raju, H., Gray, B., Orchard, J. (2024). Relative utility of portable ECG devices in capturing arrhythmias in athletes. Expert Review of Medical Devices, 21(12), 1179-1188. [More Information]
Hespe, S., Gray, B., Puranik, R., Peters, S., Sweeting, J., Ingles, J. (2024). The role of genetic testing in management and prognosis of individuals with inherited cardiomyopathies. Trends In Cardiovascular Medicine. [More Information]
Ensam, B., Sharma, S., Papadakis, M., Devine, B., MacFarlane, P., Behr, E., Scrocco, C., Johnson, D., Wijeyeratne, Y., Bastiaenen, R., Gray, B., et al (2024). Type 1 Brugada Pattern May Be Provoked by Ajmaline in Some Healthy Subjects: Results From a Clinical Trial. Circulation, 149(21), 1693-1695. [More Information]
Gray, B., Ackerman, M., Link, M., Lampert, R. (2024). Vigorous exercise and sports participation in individuals with hypertrophic cardiomyopathy. Trends In Cardiovascular Medicine. [More Information]
Lampert, R., Barth, C., Behr, E., Bell, C., Berul, C., Bos, J., Bradley, D., Cannom, D., Cannon, B., Concannon, M., Gray, B., et al (2024). Vigorous Exercise in Patients with Congenital Long-QT Syndrome: Results of the Prospective, Observational, Multinational LIVE-LQTS Study. Circulation. [More Information]

show 5 more

2023

Isbister, J., Gray, B., Offen, S., Yeates, L., Naoum, C., Medi, C., Raju, H., Semsarian, C., Puranik, R., Sy, R. (2023). Longitudinal assessment of structural phenotype in Brugada syndrome using cardiac magnetic resonance imaging. Heart Rhythm O2, 4(1), 34-41. [More Information]
Leslie, F., Avis, S., Bagnall, R., Bendall, J., Briffa, T., Brouwer, I., Butters, A., Figtree, G., La Gerche, A., Gray, B., Semsarian, C., Sy, R., Yeates, L., et al (2023). The New South Wales Sudden Cardiac Arrest Registry: A Data Linkage Cohort Study. Heart, Lung, and Circulation, 32(9), 1069-1075. [More Information]
Hoorntje, E., Burns, C., Marsili, L., Corden, B., Parikh, V., Te Meerman, G., Gray, B., Adiyaman, A., Bagnall, R., Barge-Schaapveld, D., et al (2023). Variant Location Is a Novel Risk Factor for Individuals with Arrhythmogenic Cardiomyopathy Due to a Desmoplakin (DSP) Truncating Variant. Circulation. Genomic and Precision Medicine, 16(1), E003672. [More Information]
Lampert, R., Ackerman, M., Marino, B., Burg, M., Ainsworth, B., Salberg, L., Tome Esteban, M., Ho, C., Abraham, R., Balaji, S., Gray, B., et al (2023). Vigorous Exercise in Patients with Hypertrophic Cardiomyopathy. JAMA Cardiology, 8(6), 595-605. [More Information]

show 1 more

2022

Vivekanandam, V., Männikkö, R., Skorupinska, I., Germain, L., Gray, B., Wedderburn, S., Kozyra, D., Sud, R., James, N., Holmes, S., et al (2022). Andersen-Tawil syndrome: deep phenotyping reveals significant cardiac and neuromuscular morbidity. Brain, 145(6), 2108-2120. [More Information]
Semsarian, C., Gray, B., Haugaa, K., Lampert, R., Sharma, S., Kovacic, J. (2022). Athletic Activity for Patients With Hypertrophic Cardiomyopathy and Other Inherited Cardiovascular Diseases: JACC Focus Seminar 3/4. Journal of the American College of Cardiology, 80(13), 1268-1283. [More Information]
Castelletti, S., Gray, B., Basso, C., Behr, E., Crotti, L., Elliott, P., Gonzalez Corcia, C., D'Ascenzi, F., Ingles, J., Loeys, B., et al (2022). Indications and utility of cardiac genetic testing in athletes. European Journal of Preventive Cardiology, 29(12), 1582-1591. [More Information]
Gray, B., Baruteau, A., Antolin, A., Pittman, A., Sarganas, G., Molokhia, M., Blom, M., Bastiaenen, R., Bardai, A., Priori, S., et al (2022). Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome. Circulation. Genomic and Precision Medicine, 15(1), E003391. [More Information]
Stafford, F., Krishnan, N., Richardson, E., Butters, A., Hespe, S., Burns, C., Gray, B., Medi, C., Nowak, N., Isbister, J., Richmond, D., Singer, E., Sy, R., Yeates, L., Bagnall, R., Semsarian, C., Ingles, J., et al (2022). The role of genetic testing in diagnosis and care of inherited cardiac conditions in a specialised multidisciplinary clinic. Genome Medicine, 14(1). [More Information]

show 2 more

2021

Isbister, J., Nowak, N., Butters, A., Yeates, L., Gray, B., Sy, R., Ingles, J., Bagnall, R., Semsarian, C. (2021). "Concealed cardiomyopathy" as a cause of previously unexplained sudden cardiac arrest. International Journal of Cardiology, 324, 96-101. [More Information]
Miles, C., Asimaki, A., Ster, I., Papadakis, M., Gray, B., Westaby, J., Finocchiaro, G., Bueno-Beti, C., Ensam, B., Basu, J., et al (2021). Biventricular Myocardial Fibrosis and Sudden Death in Patients With Brugada Syndrome. Journal of the American College of Cardiology, 78(15), 1511-1521. [More Information]
Femia, J., Langlois, N., Raleigh, J., Gray, B., Othman, F., Perumal, S., Semsarian, C., Puranik, R. (2021). Comparison of conventional autopsy with post-mortem magnetic resonance, computed tomography in determining the cause of unexplained death. Forensic Science, Medicine, and Pathology, 17(1), 10-18. [More Information]
Milman, A., Behr, E., Gray, B., Johnson, D., Andorin, A., Hochstadt, A., Gourraud, J., Maeda, S., Takahashi, Y., Jm Juang, J., et al (2021). Genotype-Phenotype Correlation of SCN5A Genotype in Patients With Brugada Syndrome and Arrhythmic Events: Insights From the SABRUS in 392 Probands. Circulation. Genomic and Precision Medicine, 14(5), E003222. [More Information]

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2020

Malhotra, A., Dhutia, H., Yeo, T., Finocchiaro, G., Gati, S., Bulleros, P., Fanton, Z., Papatheodorou, E., Miles, C., Basu, J., et al (2020). Accuracy of the 2017 international recommendations for clinicians who interpret adolescent athletes' ECGs: A cohort study of 11 168 British white and black soccer players. British Journal of Sports Medicine, 54(12), 739-745. [More Information]
Finocchiaro, G., Dhutia, H., Gray, B., Ensam, B., Papatheodorou, S., Miles, C., Malhotra, A., Fanton, Z., Bulleros, P., Homfray, T., et al (2020). Diagnostic yield of hypertrophic cardiomyopathy in first-degree relatives of decedents with idiopathic left ventricular hypertrophy. Europace, 22(4), 632-642. [More Information]
Gray, B., Semsarian, C. (2020). Genetic Testing for Inherited Cardiovascular Disease: Implications of the AHA Scientific Statement for Cardiologists. Heart, Lung, and Circulation, 29(11), 1581-1584. [More Information]
Gray, B., Semsarian, C., Fatkin, D., Ingles, J., Atherton, J., Davis, A., Sanders, P., Pachter, N., Skinner, J., Stiles, M. (2020). Patients With Genetic Heart Disease and COVID-19: A Cardiac Society of Australia and New Zealand (CSANZ) Consensus Statement. Heart, Lung, and Circulation, 29(7), e85-e87. [More Information]
Clemens, D., Gray, B., Bagnall, R., Tester, D., Giudicessi, J., Maleszewski, J., Crotti, L., Schwartz, P., Matthews, E., Semsarian, C., et al (2020). Prevalence and Phenotypic Correlations of Calmodulinopathy-Causative CALM1-3 Variants Detected in a Multicenter Molecular Autopsy Cohort of Sudden Unexplained Death Victims. Circulation. Genomic and Precision Medicine, 13(6), 716-718. [More Information]
Clemens, D., Gray, B., Bagnall, R., Tester, D., Dotzler, S., Giudicessi, J., Matthews, E., Semsarian, C., Behr, E., Ackerman, M. (2020). Triadin Knockout Syndrome is Absent in a Multi-Center Molecular Autopsy Cohort of Sudden Infant Death Syndrome and Sudden Unexplained Death in the Young and is Extremely Rare in the General Population. Circulation. Genomic and Precision Medicine, 13(2), 52-58. [More Information]
Gray, B., Semsarian, C. (2020). Utility of genetic testing in athletes. Clinical Cardiology, 43(8), 915-920. [More Information]
Semsarian, C., Orchard, J., Gray, B., Orchard, J. (2020). When do athletes benefit from cardiac genetic testing? British Journal of Sports Medicine, 54(15), 939-940. [More Information]

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2019

Yeates, L., Ingles, J., Gray, B., Singarayar, S., Sy, R., Semsarian, C., Bagnall, R. (2019). A balanced translocation disrupting SCN5A in a family with Brugada syndrome and sudden cardiac death. Heart Rhythm, 16(2), 231-238. [More Information]
Gray, B., Ackerman, M., Semsarian, C., Behr, E. (2019). Evaluation After Sudden Death in the Young. Circulation. Arrhythmia and Electrophysiology, 12(8), 1-9. [More Information]
Gray, B., Tester, D., Wong, L., Chanana, P., Jaye, A., Evans, J., Baruteau, A., Evans, M., Fleming, P., Jeffrey, I., et al (2019). Noncardiac genetic predisposition in sudden infant death syndrome. Genetics in Medicine, 21(3), 641-649. [More Information]
Miles, C., Finocchiaro, G., Papadakis, M., Gray, B., Westaby, J., Ensam, B., Basu, J., Parry-Williams, G., Papatheodorou, E., Paterson, C., et al (2019). Sudden Death and Left Ventricular Involvement in Arrhythmogenic Cardiomyopathy. Circulation, 139(15), 1786-1797. [More Information]

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2018

Gray, B., Semsarian, C. (2018). Editorial commentary: Will the real long QT genes please stand up. Trends In Cardiovascular Medicine, 28(7), 465-466. [More Information]
Tester, D., Wong, L., Chanana, P., Gray, B., Jaye, A., Evans, J., Evans, M., Fleming, P., Jeffrey, I., Cohen, M., et al (2018). Exome-Wide Rare Variant Analyses in Sudden Infant Death Syndrome. The Journal of Pediatrics, 203, 423-428. [More Information]
Gray, B., Hasdemir, C., Ingles, J., Aiba, T., Makita, N., Probst, V., Wilde, A., Newbury-Ecob, R., Sheppard, M., Semsarian, C., Sy, R., et al (2018). Lack of genotype-phenotype correlation in Brugada Syndrome and Sudden Arrhythmic Death Syndrome families with reported pathogenic SCN1B variants. Heart Rhythm, 15(7), 1051-1057. [More Information]
Gray, B., Gnanappa, G., Bagnall, R., Femia, G., Yeates, L., Ingles, J., Burns, C., Puranik, R., Grieve, S., Semsarian, C., Sy, R. (2018). Relations between right ventricular morphology and clinical, electrical and genetic parameters in Brugada Syndrome. PloS One, 13(4), 1-14. [More Information]
Papadakis, M., Papatheodorou, E., Mellor, G., Raju, H., Bastiaenen, R., Wijeyeratne, Y., Wasim, S., Ensam, B., Finocchiaro, G., Gray, B., et al (2018). The Diagnostic Yield of Brugada Syndrome After Sudden Death With A Normal Autopsy. Journal of the American College of Cardiology, 71(11), 1204-1214. [More Information]

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2017

Gray, B., Ingles, J., Medi, C., Driscoll, T., Semsarian, C. (2017). Cardiovascular Effects of Energy Drinks in Familial Long QT Syndrome: A Randomized Cross-Over Study. International Journal of Cardiology, 231, 150-154. [More Information]
Gray, B., Kirby, A., Kabunga, P., Freedman, S., Yeates, L., Kanthan, A., Medi, C., Keech, A., Semsarian, C., Sy, R. (2017). Twelve-lead ambulatory electrocardiographic monitoring in Brugada syndrome: Potential diagnostic and prognostic implications. Heart Rhythm, 14(6), 866-874. [More Information]

2016

Gray, B., Bagnall, R., Lam, L., Ingles, J., Turner, C., Haan, E., Davis, A., Yang, P., Clancy, C., Sy, R., Semsarian, C. (2016). A novel heterozygous mutation in cardiac calsequestrin causes autosomal dominant catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm, 13(8), 1652-1660. [More Information]
Burns, C., Ingles, J., Davis, A., Connell, V., Gray, B., Hunt, L., McGaughran, J., Semsarian, C. (2016). Clinical and genetic features of Australian families with long QT syndrome: A registry-based study. Journal of Arrhythmia, 32(6), 456-461. [More Information]
Gray, B., Klimis, H., Inam, S., Ariyathna, N., Kumar, S., Bailey, B., Patel, S. (2016). Corrigendum to 'Radiation Exposure During Cardiac Catheterisation is Similar for Both Femoral and Radial Approaches' Heart, Lung and Circulation (2015) 24, 264-269. Heart, Lung, and Circulation, 25(10), 1043. [More Information]
Gray, B., Behr, E. (2016). New Insights into the Genetic Basis of Inherited Arrhythmia Syndromes. Circulation: Cardiovascular Genetics, 9(6), 569-577. [More Information]

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2015

Earle, N., Ingles, J., Bagnall, R., Gray, B., Crawford, J., Smith, W., Shelling, A., Love, D., Semsarian, C., Skinner, J. (2015). NOS1AP polymorphisms modify QTc interval duration but not cardiac arrest risk in hypertrophic cardiomyopathy. Journal of Cardiovascular Electrophysiology, 26(12), 1346-1351. [More Information]
Gray, B., Klimis, H., Inam, S., Ariyathna, N., Kumar, S., Bailey, B., Patel, S. (2015). Radiation Exposure During Cardiac Catheterisation is Similar for Both Femoral and Radial Approaches. Heart, Lung, and Circulation, 24(3), 264-269. [More Information]
Ingles, J., Johnson, R., Sarina, T., Yeates, L., Burns, C., Gray, B., Ball, K., Semsarian, C. (2015). Social determinants of health in the setting of hypertrophic cardiomyopathy. International Journal of Cardiology, 184(1), 743-749. [More Information]

2014

Gray, B., Semsarian, C., Sy, R. (2014). Brugada Syndrome: A Heterogeneous Disease with a Common ECG Phenotype? Journal of Cardiovascular Electrophysiology, 25(4), 450-456. [More Information]
Puranik, R., Gray, B., Lackey, H., Yeates, L., Parker, G., Duflou, J., Semsarian, C. (2014). Comparison of conventional autopsy and magnetic resonance imaging in determining the cause of sudden death in the young. Journal of Cardiovascular Magnetic Resonance, 16(1), 1-11. [More Information]
Gray, B., McGuire, M., Semsarian, C., Medi, C. (2014). Late positive flecainide challenge test for Brugada syndrome. Heart Rhythm, 11(5), 898-900. [More Information]
Gray, B., Spies, J., Ng, M. (2014). Severe hypertensive encephalopathy following percutaneous balloon aortic valvuloplasty for aortic stenosis. International Journal of Cardiology, 171(3), e63-e64. [More Information]

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2013

Yu, Y., Gray, B., Lowe, H., Halmagyi, G., Ng, M. (2013). Dual modality intravascular imaging of unstable, symptomatic but "hemodynamically insignificant" carotid stenosis. Journal of Neurology, 260(7), 1934-1935. [More Information]
Gray, B., Yeates, L., Medi, C., Ingles, J., Semsarian, C. (2013). Homozygous mutation in the cardiac troponin I gene: Clinical heterogeneity in hypertrophic cardiomyopathy. International Journal of Cardiology, 168(2), 1530-1531. [More Information]
Gray, B., Ingles, J., Medi, C., Semsarian, C. (2013). Prolongation of the QTc Interval Predicts Appropriate Implantable Cardioverter-Defibrillator Therapies in Hypertrophic Cardiomyopathy. JACC: Heart Failure, 1(2), 149-155. [More Information]

2012

Gray, B., Das K, J., Semsarian, C. (2012). Consumption of energy drinks: A new provocation test for primary arrhythmogenic diseases? International Journal of Cardiology, 159(1), 77-78. [More Information]

2011

Gray, B., Ingles, J., Semsarian, C. (2011). Natural history of genotype positive-phenotype negative patients with hypertrophic cardiomyopathy. International Journal of Cardiology, 152(2), 258-259. [More Information]
Gray, B., MacDonald, P., Kuchar, D. (2011). Reversal of cardiomyopathy with ivabradine. Internal Medicine Journal, 41(2), 213-214. [More Information]

Selected Grants

2024

Improving our understanding of athlete's heart through advanced phenotyping, genomics and multiomics profiling., Gray B, National Heart Foundation of Australia/Future Leader Fellowship

2023

The Elusive Hearts Study: Using genomics to diagnose and manage inherited cardiovascular diseases, Ingles J, Semsarian C, Stark Z, Zentner D, Konstantinov I, Atherton J, MacArthur D, Bagnall R, Gray B, Skinner J, Deveson I, Siggs O, G.Weintraub R, McGaughran J, Vandenberg J, Department of Health and Aged Care (Federal - administered by NHMRC)/Cardiovascular Health Mission - 2022 Cardiovascular Health Grant

2020

Multi-Omics cardiac profiling in athletes, Gray B, Cardiovascular Initiative/Catalyst Awards

2017

Application of genomic technologies for the diagnosis and management of genetic heartdiseases, Gray B, National Health and Medical Research Council (NHMRC)/Early Career Fellowships

2016

Visit to Prof Silvia Priori's Molecular Cardiology Laboratory, New York USA, Gray B, National Heart Foundation of Australia/Collaboration and Exchange Award

2014

Cardiovascular Effects of Energy Drinks, Gray B, Semsarian C, Driscoll T, National Heart Foundation of Australia/Vanguard Grant

Further Grants

2022 MRFF Cardiovascular Health Mission (NHMRC) Grant “The Elusive Hearts Study: Using genomics to diagnose and manage inherited cardiovascular disease” Chief Investigator $1,499,286 (3yr)

Invited Contributions/Talks (Last 5 years only)

Invited Guideline Writing:

2024 HRS expert consensus statement on arrhythmias in the athlete: evaluation, treatment and return to play. Heart Rhythm.

EAPC scientific statement on genetic testing in athletes (Co-Lead) 2020

CSANZ Cardiac Genetics Council Consensus Statement for management of genetic heart disease patients with COVID19

Invited Reviewer:

Heart Rhythm Society, USA 2023 Young Investigator Awards. Judge and Chair of session

ESC Guidelines in Sports Cardiology 2020

NHMRC Project Grant (2018-)

Invited Talks:

Genotype Guided Return to Play for athletes with cardiomyopathies. Asia Pacific Heart Rhythm Meeting September 2024

Understanding Genetic Testing in Sports Cardiology. Blacktown Hospital. June 2024

Do’s and Don’ts of Genetic Testing in Athletes. Care of the Athletic Heart. American College of Cardiology Washington USA. June 2024

Genetic Testing in Athletes: current and future.Port Douglas Heart Meeting. June 2024

HCM and Mavacamtem Symposium. International Clinical Cardiovascular Genetics Meeting Brisbane May 2024

Genotype guided therapies in Inherited Arrhythmia Syndromes. International Clinical Cardiovascular Genetics Meeting Brisbane 2024

Sports Eligibility for patients with Genetic Heart Disease. ESC Preventive Cardiology Scientific Sessions, Athens Greece. April 2024

Sports participation in Genetic Heart Disease. Cardiac Society of Australia and New Zealand August 2023

Genotype Associated Syndromes. Cardiac Society of Australia and New Zealand Annual Scientific Meeting August 2023

Hypertrophic cardiomyopathy and mavacamtem. Cardiac Society of Australia and New Zealand Meeting August 2023

Is there a role for genetics in sports cardiology?International Sports Cardiology and Sudden Death Symposium 2023

Overview of Cardiomyopathies, International Clinical Cardiovascular Genetics Meeting 2022

Genotype-guided therapies in Long QT Syndrome, International Clinical Cardiovascular Genetics Meeting 2022

Genetics and Sports, Cardiac Society of Australia and New Zealand Annual Scientific Meeting 2021

Athletes heart and sudden cardiac death; when to worry? Mater Hospital Grand Rounds 2021

Genetic Testing: ? for all athletes, ESC Preventive Cardiology Meeting 2021

Clinical Evaluation of Families following Sudden Cardiac Death, European Society of Cardiology Annual Scientific Meeting 2020

Inherited Cardiomyopathies. 4 Corners of Cardiology Meeting, Melbourne, Australia 2020

Cardiac Screening and Sudden Cardiac Death. Football Federation of Australia, Medical Workshop, 2019, Sydney, Australia

Understanding the Athlete’s Heart. Sydney Local Health District Innovation and Research Symposium, 2019, Sydney Australia

The Female Athlete’s Heart. Heart Foundation Women in Heart Disease Forum. 2019 Sydney, Australia

Addressing uncertainty - does it matter which career path you choose?On The Wards 2019, Sydney, Australia.

Update on Genetic Testing in athletes. Online Sports Heart Summit 2019

Pitfalls in Genetic Testing: What to think about in the athlete before ordering the test. Baker Sports Cardiology Seminar 2019, Melbourne, Australia

Molecular Autopsy after a Sudden Cardiac Death: Ready for Prime Time? Cardiac Risk in the Young Annual Conference, 2018 London, UK.

Risk of Sports in CPVT. Heart Rhythm Congress 2018, Birmingham UK

How to differentiate Athlete’s heart from Hypertrophic Cardiomyopathy: Cardiac Imaging in Cardiomyopathies and Athlete’s Heart Short course, St George’s University of London, 2018, London, UK.

Understanding Sudden Cardiac Death: Welsh Cardiac Society Annual Meeting, 2018 Manchester, UK.

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Associate Professor Belinda Gray

Publications

By Type

By Year

Selected Grants

2024

2023

2020

2017

2016

2014

Further Grants

Invited Contributions/Talks (Last 5 years only)