People_
Dr Brigitte Nanan
Scientific Officer
Paediatrics & Child Health, Nepean Clinical School
Paediatrics & Child Health, Nepean Clinical School
Infection and Immunological Conditions
Publications
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Journals
- Lai, C., Santner-Nanan, B., Maltese, P., Ong, C., Palmer, D., Campbell, D., Makrides, M., Gold, M., Nanan, R., Prescott, S., Hsu, P. (2025). Impaired calcium influx underlies skewed T helper cell differentiation in children with IgE-mediated food allergies. Allergy, 80(2), 513-524. [More Information]
- Reyes, J., Ni, D., Santner-Nanan, B., Pinget, G., Kraftova, L., Ashhurst, T., Marsh-Wakefield, F., Wishart, C., Tan, J., Hsu, P., King, N., Macia, L., Nanan, R. (2024). A unique human cord blood CD8+CD45RA+CD27+CD161+ T-cell subset identified by flow cytometric data analysis using Seurat. Immunology, 173(1), 106-124. [More Information]
- Ni, D., Reyes, J., Nanan, B., Pinget, G., Kraftova, L., Ashhurst, T., Marshwakefield, F., Wishart, C., Tan, J., Hsu, P., King, N., Macia, L., Nanan, R. (2024). A unique human cord blood CD8+CD45RA+CD27+CD161+T cell subset identified by flow cytometric data analysis using Seurat. European Journal of Immunology, 54(Suppl 1), 714-714. [More Information]
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Conferences
- Fazekas de St Groth, B., Seddiki, N., Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Nanan, R., Kelleher, A. (2006). Expression of IL-2 and IL-7 receptors discriminates between human regulatory and activated T-cells within CD45RA and CD45RO compartments. Federation of Clinical Immunology Societies (FOCIS) Annual Meeting 2006, USA: Academic Press.
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2025
- Lai, C., Santner-Nanan, B., Maltese, P., Ong, C., Palmer, D., Campbell, D., Makrides, M., Gold, M., Nanan, R., Prescott, S., Hsu, P. (2025). Impaired calcium influx underlies skewed T helper cell differentiation in children with IgE-mediated food allergies. Allergy, 80(2), 513-524. [More Information]
2024
- Reyes, J., Ni, D., Santner-Nanan, B., Pinget, G., Kraftova, L., Ashhurst, T., Marsh-Wakefield, F., Wishart, C., Tan, J., Hsu, P., King, N., Macia, L., Nanan, R. (2024). A unique human cord blood CD8+CD45RA+CD27+CD161+ T-cell subset identified by flow cytometric data analysis using Seurat. Immunology, 173(1), 106-124. [More Information]
- Ni, D., Reyes, J., Nanan, B., Pinget, G., Kraftova, L., Ashhurst, T., Marshwakefield, F., Wishart, C., Tan, J., Hsu, P., King, N., Macia, L., Nanan, R. (2024). A unique human cord blood CD8+CD45RA+CD27+CD161+T cell subset identified by flow cytometric data analysis using Seurat. European Journal of Immunology, 54(Suppl 1), 714-714. [More Information]
2022
- Lee, C., Huang, S., Hsu, P., Leong, R., Nanan, B., Nanan, R. (2022). Low-dose IL-2 may enhance the effect of vedolizumab. Scandinavian Journal of Gastroenterology, 57(11), 1404-1405. [More Information]
- Hu, M., Alhamwe, B., Nanan, B., Miethe, S., Harb, H., Renz, H., Potaczek, D., Nanan, R. (2022). Short-Chain Fatty Acids Augment Differentiation and Function of Human Induced Regulatory T Cells. International Journal of Molecular Sciences, 23(10), 5740. [More Information]
2021
- Wang, Y., Gloss, B., Tang, B., Dervish, S., Nanan, B., Whitehead, C., Masters, K., Skarratt, K., Teoh, S., Schibeci, S., Fewings, N., et al (2021). Immunophenotyping of Peripheral Blood Mononuclear Cells in Septic Shock Patients With High-Dimensional Flow Cytometry Analysis Reveals Two Subgroups With Differential Responses to Immunostimulant Drugs. Frontiers in Immunology, 12, 634127. [More Information]
- Lai, C., Campbell, D., Palmer, D., Makrides, M., Nanan, B., Santner-Nanan, B., Gold, M., Tan, J., Valerio, C., Nanan, R., Hsu, P., et al (2021). Longitudinal egg-specific regulatory T- and B-cell development: Insights from primary prevention clinical trials examining the timing of egg introduction. Allergy, 76(5), 1385-1397. [More Information]
2019
- Hu, M., Eviston, D., Hsu, P., Marino, E., Chidgey, A., Nanan, B., Wong, K., Richards, J., Yap, Y., Collier, F., Quinton, A., Joung, S., Peek, M., Benzie, R., Macia, L., Nanan, R., et al (2019). Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia. Nature Communications, 10(1), 1-13. [More Information]
2018
- Hsu, P., Lai, C., Hu, M., Nanan, B., Dahlstrom, J., Lee, C., Ajmal, A., Bullman, A., Arbuckle, S., Al Saedi, A., Campbell, D., Nanan, R., et al (2018). IL-2 enhances gut homing potential of human naive regulatory t cells early in life. Journal of Immunology, 200(12), 3970-3980. [More Information]
2016
- Li, Q., Lee, C., Peters, L., Mastropaolo, L., Thoeni, C., Elkadri, A., Schwerd, T., Zhu, J., Zhang, B., Zhao`, Y., Hu, M., Nanan, R., Nanan, B., Gaskin, K., et al (2016). Variants in TRIM22 That Affect NOD2 Signaling Are Associated With Very-Early-Onset Inflammatory Bowel Disease. Gastroenterology, 150(5), 1196-1207. [More Information]
2015
- Hsu, P., Nanan, B., Hu, M., Skarratt, K., Lee, C., Stormon, M., Wong, M., Fuller, S., Nanan, R. (2015). IL-10 potentiates differentiation of human induced regulatory T cells via STAT3 and Foxo1. Journal of Immunology, 195(8), 3665-3674. [More Information]
- Vidal, C., Li, W., Nanan, B., Lim, C., Guillemin, G., Ball, H., Hunt, N., Nanan, R., Duque, G. (2015). The kynurenine pathway of tryptophan degradation is activated during osteoblastogenesis. Stem Cells, 33(1), 111-121. [More Information]
2014
- Hsu, P., Nanan, B., Joung, S., Peek, M., Nanan, R. (2014). Expansion of CD4+HLA-G+ T Cell in Human Pregnancy is Impaired in Pre-Eclampsia. American Journal of Reproductive Immunology, 71(3), 217-228. [More Information]
- Neller, M., Nanan, B., Brennan, R., Hsu, P., Joung, S., Nanan, R., Burrows, S., Miles, J. (2014). Multivariate Analysis Using High Definition Flow Cytometry Reveals Distinct T Cell Repertoires between the Fetal-Maternal Interface and the Peripheral Blood. Frontiers in Immunology, 5, 1-6. [More Information]
- Lee, C., Hsu, P., Nanan, B., Nanan, R., Wong, M., Gaskin, K., Leong, R., Murchie, R., Muise, A., Stormon, M. (2014). Novel de novo mutations of the interleukin-10 receptor gene lead to infantile onset inflammatory bowel disease. Journal of Crohn's and Colitis, 8(11), 1551-1556. [More Information]
2013
- Nanan, B., Straubinger, K., Hsu, P., Parnell, G., Tang, B., Xu, B., Makris, A., Hennessy, A., Peek, M., Busch, D., Nanan, R., et al (2013). Fetal-maternal alignment of regulatory T cells correlates with IL-10 and Bcl-2 upregulation in pregnancy. Journal of Immunology, 191(1), 145-153. [More Information]
2012
- Hsu, P., Nanan, B., Dahlstrom, J., Fadia, M., Chandra, A., Peek, M., Nanan, R. (2012). Altered Decidual DC-SIGN+ Antigen-Presenting Cells and Impaired Regulatory T-Cell Induction in Preeclampsia. American Journal of Pathology, 181(6), 2149-2160. [More Information]
- Nalos, M., Nanan, B., Parnell, G., Tang, B., McLean, A., Nanan, R. (2012). Immune effects of interferon gamma in persistent staphylococcal sepsis. American Journal of Respiratory and Critical Care Medicine, 185(1), 110-112. [More Information]
2010
- Suryani, S., Fulcher, D., Nanan, B., Nanan, R., Wong, M., Shaw, P., Gibson, J., Williams, A., Tangye, S. (2010). Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells. Blood, 115(3), 519-529. [More Information]
2009
- Ma, C., Suryani, S., Avery, D., Chan, A., Nanan, R., Nanan, B., Deenick, E., Tangye, S. (2009). Early commitment of naive human CD4(+) T cells to the T follicular helper (T-FH) cell lineage is induced by IL-12. Immunology and Cell Biology, 87(8), 590-600. [More Information]
- Seddiki, N., Sasson, S., Nanan, B., Munier, M., van Bockel, D., Ip, S., Marriott, D., Pett, S., Nanan, R., Cooper, D., et al (2009). Proliferation of weakly suppressive regulatory CD4+ T cells is associated with over-active CD4+ T-cell responses in HIV-positive patients with mycobacterial immune restoration disease. European Journal of Immunology, 39, 391-403. [More Information]
- Santner-Nanan, B., Peek, M., Khanam, R., Richarts, L., Zhu, E., Fazekas de St Groth, B., Nanan, R. (2009). Systemic increase in the ratio between Foxp3+ and IL-17-producing CD4+ T cells in healthy pregnancy but not in preeclampsia. Journal of Immunology, 183(11), 7023-7030. [More Information]
2008
- Nanan, B., Seddiki, N., Zhu, E., Quent, V., Kelleher, A., Fazekas de St Groth, B., Nanan, R. (2008). Accelerated age-dependent transition of human regulatory T cells to effector memory phenotype. International Immunology, 20(3), 375-383. [More Information]
- Nalos, M., Huang, S., Sluyter, R., Khan, A., Nanan, B., Nanan, R., McLean, A. (2008). Host tissue damage signal ATP impairs IL-12 and IFN {gamma} secretion in LPS stimulated whole human blood. Intensive Care Medicine, 34(10), 1891-1897. [More Information]
- Avery, D., Ma, C., Bryant, V., Nanan, B., Nanan, R., Wong, M., Fulcher, D., Cook, M., Tangye, S. (2008). STAT3 is required for IL-21-induced secretion of IgE from human naïve B cells. Blood, 112(5), 1784-1793. [More Information]
2006
- Fazekas de St Groth, B., Seddiki, N., Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Nanan, R., Kelleher, A. (2006). Expression of IL-2 and IL-7 receptors discriminates between human regulatory and activated T-cells within CD45RA and CD45RO compartments. Federation of Clinical Immunology Societies (FOCIS) Annual Meeting 2006, USA: Academic Press.
- Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S., Nanan, R., Fazekas de St Groth, B., et al (2006). Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. The Journal of Experimental Medicine, 203(7), 1693-1700. [More Information]
- Seddiki, N., Nanan, B., Tangye, S., Alexander, S., Solomon, M., Soon, L., Nanan, R., Fazekas de St Groth, B. (2006). Persistence of naive CD45RA(+) regulatory T cells in adult life. Blood, 107(7), 2830-2838. [More Information]
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2005
- Nanan, B., Peek, M., McCullagh, P., Nanan, R. (2005). Therapeutic potential of stem cells in perinatal medicine. Australian and New Zealand Journal of Obstetrics and Gynaecology, 45(2), 102-107. [More Information]
2003
- Klein-Hessling, S., Jha, M., Nanan, B., Berberich-Siebelt, F., Baumruker, T., Schimpl, A., Serfling, E. (2003). Protein Kinase A Regulates GATA-3-Dependent Activation of IL-5 Gene Expression in Th2 Cells. Journal of Immunology, 170, 2956-2961. [More Information]
2002
- Chuvpilo, S., Jankevics, E., Tyrsin, D., Akimzhanov, A., Moroz, D., Jha, M., Schulze-Luehrmann, J., Nanan, B., et al (2002). Autoregulation of NFATc1/A Expression Facilitates Effector T Cells to Escape from Rapid Apoptosis. Immunity, 16, 881-895.
- Schulze-Luehrmann, J., Nanan, B., Jha, M., Schimpl, A., Avots, A., Seroing, E. (2002). Hematopoietic progenitor kinase 1 supports apoptosis of T lymphocytes. Blood, 100, 954-960.
Selected Grants
2022
- Inflammatory bowel diseases specifically IBD, Nanan R, Lee C, Nanan B, Australian Women and Childrens Research Foundation (OZWAC)/Research Grant
- The effectiveness of mRNA COVID-19 vaccine on babies when vaccination is given to pregnant mothers., Nanan R, Nanan B, Australian Women and Childrens Research Foundation (OZWAC)/Research Grant
2012
- Analysis of CD4+HLA-G+ regulatory cells in healthy pregnancy and preeclampsia , Nanan B, Australian Women and Childrens Research Foundation (OZWAC)/Medical Research Project Grant
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