People_

Dr Caroline Reddel

Adjunct Lecturer, Medical Sciences Administration
Research Fellow,ANZAC Research Institute,Concord Clinical School
Faculty of Medicine and Health

Phone

+61 2 9767 9100

Fax

+61 2 9767 9101

Email

caroline.reddel@sydney.edu.au

Biographical details

Dr Caroline Reddel completed her PhD in 2009 through the University of Sydney, under the supervision of Prof Tony Weiss in the School of Molecular Bioscience. She currently works as a post-doctoral scientist in the Vascular Biology Group at ANZAC Research Institute, associated with the Cardiology and Haematology departments at Concord Hospital.

Research interests

Dr Reddel's research interests include thrombosis and platelet activation in the context of various thrombotic conditions, and her expertise centres around novel global coagulation assays and detection of coagulation-relevant microparticles. Her work largely involves the use of these markers in risk stratification of clinical groups including coronary artery disease, coronary bypass, multiple myeloma and schizophrenia, as well as understanding the clinically variable effects of anticoagulant medication on global coagulation. She has also been involved in developing and employing these assays for use in hypercoagulable mouse models.

Themes

Obesity, Diabetes and Cardiovascular Disease, Cancer

Keywords

Asthma, Atherosclerosis, Cardiovascular diseases, Haematology, Thrombosis

Publications

By Type

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Journals

Pennings, G., Reddel, C., Chen, V., Gnanenthiran, S., Kritharides, L. (2023). Perspective: Collagen induced platelet activation via the GPVI receptor as a primary target of colchicine in cardiovascular disease. Frontiers in Cardovascular Medicine, 9. [More Information]
Reddel, C., Pennings, G., Chen, V., Gnanenthiran, S., Kritharides, L. (2022). Colchicine as a Modulator of Platelet Function: A Systematic Review. Seminars in Thrombosis and Hemostasis, 48(5), 552-567. [More Information]
Gnanenthiran, S., Pennings, G., Reddel, C., Campbell, H., Kockx, M., Hamilton, J., Chen, V., Kritharides, L. (2022). Identification of a Distinct Platelet Phenotype in the Elderly: ADP Hypersensitivity Coexists with Platelet PAR (Protease-Activated Receptor)-1 and PAR-4-Mediated Thrombin Resistance. Arteriosclerosis, Thrombosis, and Vascular Biology, 42(8), 960-972. [More Information]
Pennings, G., Reddel, C., Traini, M., Lam, M., Kockx, M., Chen, V., Kritharides, L. (2022). Rapid Release of Interleukin-1β from Human Platelets Is Independent of NLRP3 and Caspase. Thrombosis and Haemostasis, 122(4), 517-528. [More Information]
Reddel, C., Pennings, G., Lau, J., Chen, V., Kritharides, L. (2021). Circulating platelet-derived extracellular vesicles are decreased after remote ischemic preconditioning in patients with coronary disease: A randomized controlled trial. Journal of Thrombosis and Haemostasis, 19(10), 2605-2611. [More Information]
Pennings, G., Reddel, C., Traini, M., Campbell, H., Chen, V., Kritharides, L. (2021). Colchicine inhibits ROS generation in response to glycoprotein VI stimulation. Scientific Reports, 11(1), 11965. [More Information]
Lau, J., Pennings, G., Reddel, C., Campbell, H., Liang, H., Traini, M., Gardiner, E., Yong, A., Chen, V., Kritharides, L. (2020). Remote ischemic preconditioning inhibits platelet αIIbβ3 activation in coronary artery disease patients receiving dual antiplatelet therapy: A randomized trial. Journal of Thrombosis and Haemostasis, 18(5), 1221-1232. [More Information]
Reddel, C., Tan, C., Chen, V. (2019). Thrombin Generation and Cancer: Contributors and Consequences. Cancers, 11(1), 1-20. [More Information]
Reddel, C., Pennings, G., Curnow, J., Chen, V., Kritharides, L. (2018). Procoagulant Effects of Low-Level Platelet Activation and Its Inhibition by Colchicine. Thrombosis and Haemostasis, 118(4), 723-733. [More Information]
Reddel, C., Allen, J., Ehteda, A., Taylor, R., Chen, V., Curnow, J., Kritharides, L., Robertson, G. (2017). Increased thrombin generation in a mouse model of cancer cachexia is partially interleukin-6 dependent. Journal of Thrombosis and Haemostasis, 15(3), 477-486. [More Information]
Chow, V., Reddel, C., Pennings, G., Scott, E., Pasqualon, T., Ng, A., Yeoh, T., Curnow, J., Kritharides, L. (2015). Global hypercoagulability in patients with schizophrenia receiving long-term antipsychotic therapy. Schizophrenia Research, 162(1-3), 175-182. [More Information]
Chow, V., Reddel, C., Pennings, G., Chung, T., Ng, A., Curnow, J., Kritharides, L. (2015). Persistent global hypercoagulability in long-term survivors of acute pulmonary embolism. Blood Coagulation and Fibrinolysis, 26(5), 537-544. [More Information]
Edelman, J., Reddel, C., Kritharides, L., Bannon, P., Fraser, J., Curnow, J., Vallely, M. (2014). Natural history of hypercoagulability in patients undergoing coronary revascularization and effect of preoperative myocardial infarction. Journal of Thoracic and Cardiovascular Surgery, 148(2), 536-543. [More Information]
Alcock, R., Reddel, C., Pennings, G., Hillis, G., Curnow, J., Brieger, D. (2014). The rebound phenomenon after aspirin cessation: The biochemical evidence. International Journal of Cardiology, 174(2), 376-378. [More Information]
Reddel, C., Curnow, J., Voitl, J., Rosenov, A., Pennings, G., Morel-Kopp, M., Brieger, D. (2013). Detection of hypofibrinolysis in stable coronary artery disease using the overall haemostatic potential assay. Thrombosis Research, 131(5), 457-462. [More Information]
Edelman, J., Fung, Y., Pennings, G., Reddel, C., Bannon, P., Bayfield, M., Kritharides, L., Fraser, J., Vallely, M. (2013). Off-pump Coronary Artery Bypass Surgery Induces Prolonged Alterations to Host Neutrophil Physiology. Shock, 39(2), 149-154. [More Information]
Khoo, T., Weatherburn, C., Kershaw, G., Reddel, C., Curnow, J., Dunkley, S. (2013). The use of FEIBA(r) in the correction of coagulation abnormalities induced by dabigatran. International Journal of Laboratory Hematology, 35(2), 222-224. [More Information]
Reddel, C., Cultrone, D., Rnjak-Kovacina, J., Weiss, A., Burgess, J. (2013). Tropoelastin modulates TGF-B1-induced expression of VEGF and CTGF in airway smooth muscle cells. Matrix Biology, 32(7-8), 407-413. [More Information]
Reddel, C., Weiss, A., Burgess, J. (2012). Elastin in asthma. Pulmonary Pharmacology & Therapeutics, 25(2), 144-153. [More Information]
Reddel, C., Weiss, A. (2004). Lamin A Expression Levels Are Unperturbed At The Normal And Mutant Alleles But Display Partial Splice Site Selection In Hutchinson-Gilford Progeria Syndrome. Journal of Medical Genetics, 41(9), 715-717. [More Information]

show 17 more

By Year

Expand all

2023

Pennings, G., Reddel, C., Chen, V., Gnanenthiran, S., Kritharides, L. (2023). Perspective: Collagen induced platelet activation via the GPVI receptor as a primary target of colchicine in cardiovascular disease. Frontiers in Cardovascular Medicine, 9. [More Information]

2022

Reddel, C., Pennings, G., Chen, V., Gnanenthiran, S., Kritharides, L. (2022). Colchicine as a Modulator of Platelet Function: A Systematic Review. Seminars in Thrombosis and Hemostasis, 48(5), 552-567. [More Information]
Gnanenthiran, S., Pennings, G., Reddel, C., Campbell, H., Kockx, M., Hamilton, J., Chen, V., Kritharides, L. (2022). Identification of a Distinct Platelet Phenotype in the Elderly: ADP Hypersensitivity Coexists with Platelet PAR (Protease-Activated Receptor)-1 and PAR-4-Mediated Thrombin Resistance. Arteriosclerosis, Thrombosis, and Vascular Biology, 42(8), 960-972. [More Information]
Pennings, G., Reddel, C., Traini, M., Lam, M., Kockx, M., Chen, V., Kritharides, L. (2022). Rapid Release of Interleukin-1β from Human Platelets Is Independent of NLRP3 and Caspase. Thrombosis and Haemostasis, 122(4), 517-528. [More Information]

2021

Reddel, C., Pennings, G., Lau, J., Chen, V., Kritharides, L. (2021). Circulating platelet-derived extracellular vesicles are decreased after remote ischemic preconditioning in patients with coronary disease: A randomized controlled trial. Journal of Thrombosis and Haemostasis, 19(10), 2605-2611. [More Information]
Pennings, G., Reddel, C., Traini, M., Campbell, H., Chen, V., Kritharides, L. (2021). Colchicine inhibits ROS generation in response to glycoprotein VI stimulation. Scientific Reports, 11(1), 11965. [More Information]

2020

Lau, J., Pennings, G., Reddel, C., Campbell, H., Liang, H., Traini, M., Gardiner, E., Yong, A., Chen, V., Kritharides, L. (2020). Remote ischemic preconditioning inhibits platelet αIIbβ3 activation in coronary artery disease patients receiving dual antiplatelet therapy: A randomized trial. Journal of Thrombosis and Haemostasis, 18(5), 1221-1232. [More Information]

2019

Reddel, C., Tan, C., Chen, V. (2019). Thrombin Generation and Cancer: Contributors and Consequences. Cancers, 11(1), 1-20. [More Information]

2018

Reddel, C., Pennings, G., Curnow, J., Chen, V., Kritharides, L. (2018). Procoagulant Effects of Low-Level Platelet Activation and Its Inhibition by Colchicine. Thrombosis and Haemostasis, 118(4), 723-733. [More Information]

2017

Reddel, C., Allen, J., Ehteda, A., Taylor, R., Chen, V., Curnow, J., Kritharides, L., Robertson, G. (2017). Increased thrombin generation in a mouse model of cancer cachexia is partially interleukin-6 dependent. Journal of Thrombosis and Haemostasis, 15(3), 477-486. [More Information]

2015

Chow, V., Reddel, C., Pennings, G., Scott, E., Pasqualon, T., Ng, A., Yeoh, T., Curnow, J., Kritharides, L. (2015). Global hypercoagulability in patients with schizophrenia receiving long-term antipsychotic therapy. Schizophrenia Research, 162(1-3), 175-182. [More Information]
Chow, V., Reddel, C., Pennings, G., Chung, T., Ng, A., Curnow, J., Kritharides, L. (2015). Persistent global hypercoagulability in long-term survivors of acute pulmonary embolism. Blood Coagulation and Fibrinolysis, 26(5), 537-544. [More Information]

2014

Edelman, J., Reddel, C., Kritharides, L., Bannon, P., Fraser, J., Curnow, J., Vallely, M. (2014). Natural history of hypercoagulability in patients undergoing coronary revascularization and effect of preoperative myocardial infarction. Journal of Thoracic and Cardiovascular Surgery, 148(2), 536-543. [More Information]
Alcock, R., Reddel, C., Pennings, G., Hillis, G., Curnow, J., Brieger, D. (2014). The rebound phenomenon after aspirin cessation: The biochemical evidence. International Journal of Cardiology, 174(2), 376-378. [More Information]

2013

Reddel, C., Curnow, J., Voitl, J., Rosenov, A., Pennings, G., Morel-Kopp, M., Brieger, D. (2013). Detection of hypofibrinolysis in stable coronary artery disease using the overall haemostatic potential assay. Thrombosis Research, 131(5), 457-462. [More Information]
Edelman, J., Fung, Y., Pennings, G., Reddel, C., Bannon, P., Bayfield, M., Kritharides, L., Fraser, J., Vallely, M. (2013). Off-pump Coronary Artery Bypass Surgery Induces Prolonged Alterations to Host Neutrophil Physiology. Shock, 39(2), 149-154. [More Information]
Khoo, T., Weatherburn, C., Kershaw, G., Reddel, C., Curnow, J., Dunkley, S. (2013). The use of FEIBA(r) in the correction of coagulation abnormalities induced by dabigatran. International Journal of Laboratory Hematology, 35(2), 222-224. [More Information]
Reddel, C., Cultrone, D., Rnjak-Kovacina, J., Weiss, A., Burgess, J. (2013). Tropoelastin modulates TGF-B1-induced expression of VEGF and CTGF in airway smooth muscle cells. Matrix Biology, 32(7-8), 407-413. [More Information]

show 1 more

2012

Reddel, C., Weiss, A., Burgess, J. (2012). Elastin in asthma. Pulmonary Pharmacology & Therapeutics, 25(2), 144-153. [More Information]

2004

Reddel, C., Weiss, A. (2004). Lamin A Expression Levels Are Unperturbed At The Normal And Mutant Alleles But Display Partial Splice Site Selection In Hutchinson-Gilford Progeria Syndrome. Journal of Medical Genetics, 41(9), 715-717. [More Information]

Selected Grants

2020