People_

Professor Christopher Little

Director Raymond Purves Bone and Joint Research Labs
Surgery, Faculty of Medicine and Health, Northern Clinical School
Kolling Institute
Institute of Bone and Joint Research

Phone

02 9926 4800

Fax

02 9926 5266

christopher.little@sydney.edu.au

Details

Member of the Charles Perkins Centre

Websites

Institute of Bone and Joint Research

Biographical details

Professor Christopher Little is director of the Raymond Purves Bone and Joint Research Labs at the Kolling Institute of Medical Research at Royal North Shore Hospital, Australia. Chris is a qualified Veterinarian with specialist surgery training and ACVS certification. He was awarded a PhD degree from the University of Sydney in 1996 for his studies of cartilage degradation in a sheep model of osteoarthritis (OA). Following a 5-year postdoctoral position at Cardiff University (UK), he was awarded an Arthritis Foundation of Australia Fellowship at the University of Melbourne. In 2004 he moved to his current position in the University of Sydney Faculty of Medicine. Chris's research interests focus on defining the biochemical and molecular mechanisms of joint pathology in OA, and tendon and intervertebral disc degeneration, and are based on the belief that it is only though a better understanding the mechanisms that drive the initiation and progression of these diseases that new therapies can be developed. Chris is recognized internationally for his expertise in the development and use of animal models of bone and joint disease. He has served as an Associate Editor of Osteoarthritis and Cartilage, and a leader of the OARSI international initiative to establish standardised methods for evaluation of animal models of OA. Chris received the 2010 Barry Preston Award from the Matrix Biology Society of Australia and New Zealand, presented to an outstanding leader in the field.

Themes

Healthy Ageing, Lifespan

Keywords

Arthritis, Cell biology, Musculoskeletal diseases, Orthopaedics

Approaches

Animal Models, Pathogenesis, Translational Research

International links

United States

(Rush University) Professor Anne-Marie Malfait: Collaboration to investigate and determine the pathological and molecular mechanisms of joint pain in arthritis

Current research students

Project title	Research student
Understanding and modulating the senescence-mediated osteoarthritis endotype.	Sidharth ARAVIND

Publications

By Type

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Book Chapters

Gauci, S., Stanton, H., Little, C., Fosang, A. (2017). Proteoglycan and Collagen Degradation in Osteoarthritis. In Susanne Grassel, Attila Aszodi (Eds.), Cartilage: Volume 2: Pathophysiology, (pp. 41-61). Cham: Springer International Publishing. [More Information]
Smith, M., Little, C. (2007). Experimental Models of Osteoarthritis. In Moskowitz, Altman, Hochberg, Buckwalter & Glodberg (Eds.), Osteoarthritis: Diagnosis and Medical/ Surgical Management, (pp. 107-125). Philadelphia, USA: Lippincott Williams & Wilkins.
Hughes, C., Caterson, B., Little, C., Wright, S. (2004). Aggrecanases 1 and 2. In Woessner F, Alan J. Barrett, Neil D. Rawlings (Eds.), Handbook of Proteolytic Enzymes, (pp. 740-740). Canada: Academic Press.

Journals

Obeidat, A., Malfait, A., Scanzello, C., Kim, S., Burt, K., Hu, B., Li, J., Ishihara, S., Xiao, R., Miller, R., Little, C. (2024). A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis. Osteoarthritis and Cartilage. [More Information]
Alini, M., Diwan, A., Erwin, W., Little, C., Melrose, J. (2023). An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therapeutics. JOR Spine, 6(1). [More Information]
Ashton, D., Blaker, C., Hartnell, N., Haubruck, P., Hefferan, S., Little, C., Clarke, E. (2023). Challenging the Perceptions of Human Tendon Allografts: Influence of Donor Age, Sex, Height, and Tendon on Biomechanical Properties. The American Journal of Sports Medicine, 51(3), 768-778. [More Information]
Macfarlane, E., Cavanagh, L., Fong-Yee, C., Tuckermann, J., Chen, D., Little, C., Seibel, M., Zhou, H. (2023). Deletion of the chondrocyte glucocorticoid receptor attenuates cartilage degradation through suppression of early synovial activation in murine posttraumatic osteoarthritis. Osteoarthritis and Cartilage, 31(9), 1189-1201. [More Information]
Julovi, S., Dao, A., Trinh, K., O'Donohue, A., Shu, C., Smith, S., Shingde, M., Schindeler, A., Rogers, N., Little, C. (2023). Disease-modifying interactions between chronic kidney disease and osteoarthritis: A new comorbid mouse model. RMD Open, 9(3). [More Information]
Ng, J., Jafarov, T., Little, C., Wang, T., Ali, A., Ma, Y., Radford, G., Vrbanac, L., Ichinose, M., Hunter, D., et al (2023). Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis. Nature Communications, 14(1), 6909. [More Information]
Chen, R., Pye, J., Li, J., Little, C., Li, J. (2023). Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies. Bioactive Materials, 27, 505-545. [More Information]
Little, C., Zaki, S., Blaker, C., Clarke, E. (2022). Animal models of osteoarthritis. The Bone and Joint Journal, 11(8), 514-517. [More Information]
de Luca, K., Chiarotto, A., Cicuttini, F., Creemers, L., de Schepper, E., Ferreira, P., Foster, N., Hartvigsen, J., Kawchuk, G., Little, C., Ferreira, M., et al (2022). Consensus for statements regarding a definition for spinal osteoarthritis for use in research and clinical practice: A Delphi study. Arthritis Care and Research. [More Information]
Tran, T., Mach, J., Gemikonakli, G., Wu, H., Allore, H., Howlett, S., Little, C., Hilmer, S. (2022). Diurnal effects of polypharmacy with high drug burden index on physical activities over 23Â h differ with age and sex. Scientific Reports, 12(1), 2168. [More Information]
Lim, Y., Wang, Y., Estee, M., Abidi, J., Udaya Kumar, M., Hussain, S., Wluka, A., Little, C., Cicuttini, F. (2022). Metformin as a potential disease-modifying drug in osteoarthritis: a systematic review of pre-clinical and human studies. Osteoarthritis and Cartilage, 30(11), 1434-1442. [More Information]
James, G., Stecco, C., Blomster, L., Hall, L., Schmid, A., Shu, C., Little, C., Melrose, J., Hodges, P. (2022). Muscle spindles of the multifidus muscle undergo structural change after intervertebral disc degeneration. European Spine Journal, 31(7), 1879-1888. [More Information]
Zaki, S., Baker, C., Little, C. (2022). OA foundations – experimental models of osteoarthritis. Osteoarthritis and Cartilage, 30(3), 357-380. [More Information]
Vincent, T., Alliston, T., Kapoor, M., Loeser, R., Troeberg, L., Little, C. (2022). Osteoarthritis Pathophysiology: Therapeutic Target Discovery may Require a Multifaceted Approach. Clinics in Geriatric Medicine, 38(2), 193-219. [More Information]
Clement-Lacroix, P., Little, C., Smith, M., Cottereaux, C., Merciris, D., Meurisse, S., Mollat, P., Touitou, R., Brebion, F., Gosmini, R., et al (2022). Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5. Osteoarthritis and Cartilage, 30(2), 291-301. [More Information]
Liu, X., Robbins (nee: Ferreira De Meneses), S., Wang, X., Virk, S., Schuck, K., Miranda Alle Deveza, L., Oo, W., Carmichael, K., Antony, B., Eckstein, F., Little, C., O'Connell, R., Heller, G., Hunter, D., et al (2021). Efficacy and cost-effectiveness of Stem Cell injections for symptomatic relief and strUctural improvement in people with Tibiofemoral knee OsteoaRthritis: Protocol for a randomised placebo-controlled trial (the SCUlpTOR trial). BMJ Open, 11(11), e056382. [More Information]
Duong, V., Bennell, K., Clifton-Bligh, R., Miranda Alle Deveza, L., Elliott, J., Guilak, F., Hall, M., Henderson, L., Hodges, P., Johnstone, B., Little, C., Raviraj, V., Yu, S., Zaki, S., Hunter, D., et al (2021). Exploring translational gaps between basic scientists, clinical researchers, clinicians, and consumers: Proceedings and recommendations arising from the 2020 mine the gap online workshop. Osteoarthritis and Cartilage Open, 3(2), 100163. [More Information]
Ryan, S., Hosseini Beheshti, E., Afrose, D., Ding, X., Xia, B., Grau, G., Little, C., McClements, L., Li, J. (2021). Extracellular vesicles from mesenchymal stromal cells for the treatment of inflammation-related conditions. International Journal of Molecular Sciences, 22(6), 1-34. [More Information]
Kung, L., Sampurno, L., Little, C., Lamande, S., Bateman, J. (2021). Generation of a miR-26b stem-loop knockout human iPSC line, MCRIi019-A-1, using CRISPR/Cas9 editing. Stem Cell Research, 50, 1-5. [More Information]
Sammel, A., Xue, M., Karsten, E., Little, C., Smith, S., Nguyen, K., Laurent, R. (2021). Limited utility of novel serological biomarkers in patients newly suspected of having giant cell arteritis. International Journal of Rheumatic Diseases, 24(6), 781-788. [More Information]
Blaker, C., Zaki, S., Little, C., Clarke, E. (2021). Long-term Effect of a Single Subcritical Knee Injury: Increasing the Risk of Anterior Cruciate Ligament Rupture and Osteoarthritis. The American Journal of Sports Medicine, 49(2), 391-403. [More Information]
Tran, T., Mach, J., Gemikonakli, G., Wu, H., Allore, H., Howlett, S., Little, C., Hilmer, S. (2021). Male-Female Differences in the Effects of Age on Performance Measures Recorded for 23 Hours in Mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 76(12), 2141-2146. [More Information]
Haubruck, P., Pinto, M., Moradi, B., Little, C., Gentek, R. (2021). Monocytes, Macrophages, and Their Potential Niches in Synovial Joints – Therapeutic Targets in Post-Traumatic Osteoarthritis? Frontiers in Immunology, 12, 763702. [More Information]
Soul, J., Barter, M., Little, C., Young, D. (2021). OATargets: A knowledge base of genes associated with osteoarthritis joint damage in animals. Annals of the Rheumatic Diseases, 80(3), 376-383. [More Information]
Zaki, S., Smith, M., Little, C. (2021). Pathology-pain relationships in different osteoarthritis animal model phenotypes: it matters what you measure, when you measure, and how you got there. Osteoarthritis and Cartilage, 29(10), 1448-1461. [More Information]
Roos, E., Risberg, M., Little, C. (2021). Prevention and early treatment, a future focus for OA research. Osteoarthritis and Cartilage, 29(12), 1627-1629. [More Information]
Blaker, C., Ashton, D., Little, C., Clarke, E., Doran, N. (2021). Sex- and injury-based differences in knee biomechanics in mouse models of post-traumatic osteoarthritis. Journal of Biomechanics, 114, 110152-1-110152-10. [More Information]
Oo, W., Little, C., Duong, V., Hunter, D. (2021). The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date. Drug Design, Development and Therapy, 15, 2921-2945. [More Information]
Van Spil, W., Bierma-Zeinstra, S., Miranda Alle Deveza, L., Arden, N., Bay-Jensen, A., Kraus, V., Carlesso, L., Christensen, R., van der Esch, M., Kent, P., Little, C., Hunter, D., et al (2020). A consensus-based framework for conducting and reporting osteoarthritis phenotype research. Arthritis Research and Therapy, 22(1), 54. [More Information]
Sammel, A., Smith, S., Nguyen, K., Laurent, R., Brewer, J., Hall, N., Little, C. (2020). Assessment for varicella zoster virus in patients newly suspected of having giant cell arteritis. Rheumatology, 59(8), 1992-1996. [More Information]
Zaki, S., Smith, M., Smith, S., Little, C. (2020). Differential patterns of pathology in and interaction between joint tissues in long-term osteoarthritis with different initiating causes: phenotype matters. Osteoarthritis and Cartilage, 28(7), 953-965. [More Information]
Haubruck, P., Colbath, A., Liu, Y., Stoner, S., Shu, C., Little, C. (2020). Flow cytometry analysis of immune cell subsets within the murine spleen, bone marrow, lymph nodes and synovial tissue in an osteoarthritis model. Journal of Visualized Experiments, 2020 (158), e61008. [More Information]
Roelofs, A., Kania, K., Rafipay, A., Sambale, M., Kuwahara, S., Collins, F., Smeeton, J., Serowoky, M., Rowley, L., Wang, H., Little, C., et al (2020). Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis. Annals of the Rheumatic Diseases, 79(12), 1625-1634. [More Information]
Ng, J., Little, C., Woods, S., Whittle, S., Lee, F., Gronthos, S., Mukherjee, S., Hunter, D., Worthley, D. (2020). Stem cell-directed therapies for osteoarthritis: The promise and the practice. Stem Cells, 38(4), 477-486. [More Information]
Shu, C., Zaki, S., Ravi, V., Schiavinato, A., Smith, M., Little, C. (2020). The relationship between synovial inflammation, structural pathology, and pain in post-traumatic osteoarthritis: differential effect of stem cell and hyaluronan treatment. Arthritis Research and Therapy, 22(29), 1-13. [More Information]
Xue, M., Dervish, S., McKelvey, K., March, L., Wang, F., Little, C., Jackson, C. (2019). Activated protein C targets immune cells and rheumatoid synovial fibroblasts to prevent inflammatory arthritis in mice. Rheumatology, 58(10), 1850-1860. [More Information]
Blaker, C., Clarke, E., Little, C. (2019). Adding Insult to Injury: synergistic effect of combining risk-factors in models of post-traumatic osteoarthritis. Osteoarthritis and Cartilage, 27(12), 1731-1734. [More Information]
Shu, C., Flannery, C., Little, C., Melrose, J. (2019). Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs. International Journal of Molecular Sciences, 20(3), 1-21. [More Information]
Hunter, D., Nicolson, P., Little, C., Robbins (nee: Ferreira De Meneses), S., Wang, X., Bennell, K. (2019). Developing strategic priorities in osteoarthritis research: Proceedings and recommendations arising from the 2017 Australian Osteoarthritis Summit. BMC Musculoskeletal Disorders, 20(1), 1-9. [More Information]
Gauci, S., Golub, S., Tatarczuch, L., Lee, E., Chan, D., Walsh, N., Little, C., Stanton, H., Lokmic, Z., Sims, N., et al (2019). Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs. Matrix Biology, 83, 77-96. [More Information]
Tu, J., Zhang, P., Ji, Z., Henneicke, H., Li, J., Kim, S., Swarbrick, M., Wu, Y., Little, C., Seibel, M., Zhou, H. (2019). Disruption of glucocorticoid signalling in osteoblasts attenuates age-related surgically induced osteoarthritis. Osteoarthritis and Cartilage, 27(10), 1518-1525. [More Information]
Tsang, A., Dart, A., Biasutti, S., Jeffcott, L., Smith, M., Little, C. (2019). Effects of tendon injury on uninjured regional tendons in the distal limb: An in-vivo study using an ovine tendinopathy model. PloS One, 14(4), 1-24. [More Information]
Shu, C., Smith, S., Little, C., Melrose, J. (2019). Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc. Biochemical Journal, 476(2), 225-243. [More Information]
Choi, R., Smith, M., Smith, S., Little, C., Clarke, E. (2019). Functionally distinct tendons have different biomechanical, biochemical and histological responses to in vitro unloading. Journal of Biomechanics, 95, 1-10. [More Information]
Sulistio, A., Mansfeld, F., Reyes-Ortega, F., D'Souza, A., Ng, S., Birkett, S., Blencowe, A., Qiao, G., Little, C., Shu, C., et al (2019). Intra-articular Treatment of Osteoarthritis with Diclofenac-Conjugated Polymer Reduces Inflammation and Pain. ACS Applied Bio Materials, 2(7), 2822-2832. [More Information]
Li, J., Hosseini Beheshti, E., Grau, G., Zreiqat, H., Little, C. (2019). Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis. Nanomaterials, 9(2), 1-21. [More Information]
Shu, C., Smith, M., Appleyard, R., Little, C., Melrose, J. (2018). Achilles and tail tendons of perlecan exon 3 null heparan sulphate deficient mice display surprising improvement in tendon tensile properties and altered collagen fibril organisation compared to C57BL/6 wild type mice. PeerJ, 6, 1-25. [More Information]
McIlwraith, C., Kawcak, C., Frisbie, D., Little, C., Clegg, P., Peffers, M., Karsdal, M., Ekman, S., Laverty, S., Slayden, R., et al (2018). Biomarkers for equine joint injury and osteoarthritis. Journal of Orthopaedic Research, 36(3), 823-831. [More Information]
Kung, L., Ravi, V., Rowley, L., Angelucci, C., Fosang, A., Bell, K., Little, C., Bateman, J. (2018). Cartilage microRNA dysregulation during the onset and progression of mouse osteoarthritis is independent of aggrecanolysis and overlaps with candidates from end-stage human disease. Arthritis & Rheumatology, 70(3), 383-395. [More Information]
Brown, S., Matta, A., Erwin, M., Roberts, S., Gruber, H., Hanley, E., Little, C., Melrose, J. (2018). Cell clusters are indicative of stem cell activity in the degenerate intervertebral disc: can their properties be manipulated to improve intrinsic repair of the disc? Stem Cells and Development, 27(3), 147-165. [More Information]
Choi, R., Smith, M., Clarke, E., Little, C. (2018). Cellular, matrix, and mechano-biological differences in load-bearing versus positional tendons throughout development and aging: a narrative review. Connective Tissue Research, 59(5), 483-494. [More Information]
Zaki, S., Little, C. (2018). DEFINING THE PREDICTIVE UTILITY OF THE MOUSE DMM MODEL OF OSTEOARTHRITIS FOR TESTING/DEVELOPING THERAPEUTIC AGENTS. Osteoarthritis and Cartilage, 26, 1-1.
Shu, C., Dart, A., Bell, R., Dart, C., Clarke, E., Smith, M., Little, C., Melrose, J. (2018). Efficacy of Administered Mesenchymal Stem Cells in The Initiation and Co-ordination of Repair Processes By Resident Disc Cells In An Ovine (Ovis aries) Large Destabilizing Lesion Model of Experimental Disc Degeneration. JOR Spine, 1(4), 1-24. [More Information]
Fuller, E., Shu, C., Smith, M., Little, C., Melrose, J. (2018). Hyaluronan oligosaccharides stimulate matrix metalloproteinase and anabolic gene expression in vitro by intervertebral disc cells and annular repair in vivo. Journal of Tissue Engineering and Regenerative Medicine, 12(1), e216-e226. [More Information]
de Kroon, L., van den Akker, G., Brachvogel, B., Narcisi, R., Belluoccio, D., Jenner, F., Bateman, J., Little, C., Brama, P., Blaney Davidson, E., et al (2018). Identification of TGF(beta)-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets. Bone, 116, 67-77. [More Information]
James, G., Sluka, K., Blomster, L., Hall, L., Schmid, A., Shu, C., Little, C., Melrose, J., Hodges, P. (2018). Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury. European Spine Journal, 27(8), 1744-1756. [More Information]
Angelo, D., Morouco, P., Gil, F., Monico, L., Gonzalez-Garcia, R., Sousa, R., Neto, L., Caldeira, I., Smith, M., Smith, S., Little, C., et al (2018). Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS - Phase 1- histologic, imaging and body weight results. Journal of Cranio-Maxillofacial Surgery, 46(4), 688-696. [More Information]
Urban, H., Little, C. (2018). The role of fat and inflammation in the pathogenesis and management of osteoarthritis. Rheumatology, 57(suppl_4), iv10-iv21. [More Information]
Shu, C., Smith, M., Smith, S., Dart, A., Little, C., Melrose, J. (2017). A Histopathological Scheme for the Quantitative Scoring of Intervertebral Disc Degeneration and the Therapeutic Utility of Adult Mesenchymal Stem Cells for Intervertebral Disc Regeneration. International Journal of Molecular Sciences, 18(5), 1-31. [More Information]
Angelo, D., Monje, F., Gonzalez-Garcia, R., Little, C., Monico, L., Pinho, M., Santos, F., Carrapico, B., Goncalves, S., Morouco, P., et al (2017). Bioengineered Temporomandibular Joint Disk Implants: Study Protocol for a Two-Phase Exploratory Randomized Preclinical Pilot Trial in 18 Black Merino Sheep (TEMPOJIMS). Journal of Medical Internet Research, 6(3), 1-10. [More Information]
Kung, L., Ravi, V., Rowley, L., Bell, K., Little, C., Bateman, J. (2017). Comprehensive Expression Analysis of microRNAs and mRNAs in Synovial Tissue from a Mouse Model of Early Post-Traumatic Osteoarthritis. Scientific Reports, 7(1), 1-12. [More Information]
Smith, M., Clarke, E., Little, C. (2017). Considerations for the Design and Execution of Protocols for Animal Research and Treatment to improve reproducibility and standardization: "DEPART well-prepared and ARRIVE safely". Osteoarthritis and Cartilage, 25(3), 354-363. [More Information]
Blaker, C., Little, C., Clarke, E. (2017). Joint loads resulting in ACL rupture: Effects of age, sex, and body mass on injury load and mode of failure in a mouse model. Journal of Orthopaedic Research, 35(8), 1754-1763. [More Information]
Biasutti, S., Dart, A., Smith, M., Blaker, C., Clarke, E., Jeffcott, L., Little, C. (2017). Spatiotemporal variations in gene expression, histology and biomechanics in an ovine model of tendinopathy. PloS One, 12(10), 1-36. [More Information]
Melrose, J., Fuller, E., Little, C. (2017). The biology of meniscal pathology in osteoarthritis and its contribution to joint disease: beyond simple mechanics. Connective Tissue Research, 58(3-4), 282-294. [More Information]
Blaker, C., Clarke, E., Little, C. (2017). Using mouse models to investigate the pathophysiology, treatment, and prevention of post-traumatic osteoarthritis. Journal of Orthopaedic Research, 35(3), 424-439. [More Information]
Kung, L., Zaki, S., Ravi, V., Rowley, L., Smith, M., Bell, K., Bateman, J., Little, C. (2017). Utility of circulating serum miRNAs as biomarkers of early cartilage degeneration in animal models of post-traumatic osteoarthritis and inflammatory arthritis. Osteoarthritis and Cartilage, 25(3), 426-434. [More Information]
Shu, C., Jackson, M., Smith, M., Smith, S., Penm, S., Lord, M., Whitelock, J., Little, C., Melrose, J. (2016). Ablation of Perlecan domain I heparan sulfate reduces progressive cartilage degradation, synovitis, and osteophyte size in post-traumatic osteoarthritis. Arthritis & Rheumatology, 68(4), 868-879. [More Information]
Choi, R., Smith, M., Martin, J., Clarke, J., Dart, A., Little, C., Clarke, E. (2016). Chondroitin sulphate glycosaminoglycans contribute to widespread inferior biomechanics in tendon after focal injury. Journal of Biomechanics, 49, 2694-2701. [More Information]
Jackson, M., Zaki, S., Ravi, V., Babak, M., Smith, S., Fosang, A., Little, C. (2016). Defining the relationship between joint pathology and pain in osteoarthritis using genetically modified mice. Osteoarthritis and Cartilage, 24, S9-S10.
Bischofberger, A., Dart, C., Horadagoda, N., Perkins, N., Jeffcott, L., Little, C., Dart, A. (2016). Effect of Manuka honey gel on the transforming growth factor β1and β3 concentrations, bacterial counts and histomorphology of contaminated full-thickness skin wounds in equine distal limbs. Australian Veterinary Journal, 94(1-2), 27-34. [More Information]
Stankoska, K., Sarram, L., Smith, S., Bedran-Russo, A., Little, C., Swain, M., Bertassoni, L. (2016). Immunolocalization and distribution of proteoglycans in carious dentine. Australian Dental Journal, 61(3), 288-297. [More Information]
Fuller, E., Little, C., Melrose, J. (2016). Interleukin-1(alpha) induces focal degradation of biglycan and tissue degeneration in an in-vitro ovine meniscal model. Experimental and Molecular Pathology, 101(2), 214-220. [More Information]
James, G., Blomster, L., Hall, L., Schmid, A., Shu, C., Little, C., Melrose, J., Hodges, P. (2016). Mesenchymal stem cell treatment of intervertebral disc lesion prevents fatty infiltration and fibrosis of the multifidus muscle, but not cytokine and muscle fiber changes. European Spine Journal, 41(15), 1208-1217. [More Information]
Hayes, A., Shu, C., Lord, M., Little, C., Whitelock, J., Melrose, J. (2016). Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc. European Cells and Materials, 32, 40-57. [More Information]
Markway, B., Cho, H., Anderson, D., Holden, P., Ravi, V., Little, C., Johnstone, B. (2016). Reoxygenation enhances tumour necrosis factor alpha-induced degradation of the extracellular matrix produced by chondrogenic cells. European Cells and Materials, 31, 425-439. [More Information]
Melrose, J., Smith, S., Hughes, C., Little, C., Caterson, B., Hayes, A. (2016). The 7D4, 4C3 and 3B3 (-) Chondroitin Sulphation Motifs are expressed at Sites of Cartilage and Bone Morphogenesis during Foetal Human Knee Joint Development. Journal of Glycobiology, 5(1), 1-9. [More Information]
Hayes, A., Hughes, C., Smith, S., Caterson, B., Little, C., Melrose, J. (2016). The CS Sulphation Motifs 4C3, 7D4, 3B3[-]; and Perlecan Identify Stem Cell Populations and Niches, Activated Progenitor Cells and Transitional Tissue Development in the Fetal Human Elbow. Stem Cells and Development, 25(11), 836-847. [More Information]
SHU, C., Ravindran, V., Zaki, S., Smith, S., Schiavinato, A., Smith, S., Little, C. (2016). THE EFFECTS OF INTRA-ARTICULAR INJECTION OF MESENCHYMAL STEM CELLS VERSUS HYALURONAN HEXADECYLAMIDE-DERIVATIVE ON POST-TRAUMATIC OA: THE RELATIONSHIP BETWEEN SYNOVIAL INFLAMMATION, STRUCTURAL PATHOLOGY AND PAIN SENSITISATION. Osteoarthritis and Cartilage, 24, 1-23.
Hunter, D., Little, C. (2016). The great debate: Should Osteoarthritis Research Focus on "Mice" or "Men"? Osteoarthritis and Cartilage, 24(1), 4-8. [More Information]
Bertassoni, L., Kury, M., Rathsam, C., Little, C., Swain, M. (2016). The role of proteoglycans in the nanoindentation creep behavior of human dentin. Journal of the Mechanical Behavior of Biomedical Materials, 55, 264-270. [More Information]
Shu, C., Smith, S., Little, C., Melrose, J. (2016). Use of FGF-2 and FGF-18 to direct bone marrow stromal stem cells to chondrogenic and osteogenic lineages. Future Science OA, 2(4), 1-19. [More Information]
Jacobsen, E., Dart, A., Mondori, T., Horadagoda, N., Jeffcott, L., Little, C., Smith, M. (2015). Focal experimental injury leads to widespread gene expression and histologic changes in equine flexor tendons. PloS One, 10(4), 1-25. [More Information]
Hodges, P., James, G., Blomster, L., Hall, L., Schmid, A., Shu, C., Little, C., Melrose, J. (2015). Multifidus Muscle Changes after Back Injury Are Characterized by Structural Remodeling of Muscle, Adipose and Connective Tissue, but Not Muscle Atrophy: Molecular and Morphological Evidence. Spine, 40(14), 1057-1071. [More Information]
Malfait, A., Little, C. (2015). On the predictive utility of animal models of osteoarthritis. Arthritis Research and Therapy, 17(1), 1-14. [More Information]
Jackson, M., Babak, M., Smith, M., Jackson, C., Little, C. (2014). Activation of matrix metalloproteinases 2, 9, and 13 by activated protein c in human osteoarthritic cartilage chondrocytes. Arthritis & Rheumatology, 66(6), 1525-1536. [More Information]
Smith, R., McIlwraith, W., Schweitzer, R., Kadler, K., Cook, J., Caterson, B., Dakin, S., Heinegard, D., Screen, H., Stover, S., Little, C., et al (2014). Advances in the understanding of tendinopathies: a report on the Second Havemeyer Workshop on equine tendon disease. Equine Veterinary Journal, 46(11), 4-9. [More Information]
Hodges, P., James, G., Blomster, L., Hall, L., Schmid, A., Shu, C., Little, C., Melrose, J. (2014). Can Proinflammatory Cytokine Gene Expression Explain Multifidus Muscle Fiber Changes After an Intervertebral Disc Lesion? Spine, 39(13), 1010-1017. [More Information]
Zaki, S., Miller, R., Malfait, A., Smith, S., Tran, P., Ishihara, S., Little, C. (2014). CHARACTERISATION OF PAIN-RELATED BEHAVIOURS IN ASSOCIATION WITH JOINT PATHOLOGY IN AN 8-WEEK ANTIGENINDUCED ARTHRITIS MODEL. Osteoarthritis and Cartilage, 22, 1-2.
Jackson, M., Moradi, B., Zaki, S., Smith, M., McCracken, S., Smith, S., Jackson, C., Little, C. (2014). Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms. Arthritis & Rheumatology, 66(12), 3337-3348. [More Information]
Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research and Therapy, 16(1), 1-12. [More Information]
Miller, R., Zaki, S., Ishihara, S., Tran, P., Little, C., Malfait, A. (2014). ESTABLISHING A METHOD FOR MEASURING PRIMARY KNEE HYPERALGESIA IN THE MURINE DMM MODEL OF OSTEOARTHRITIS. Osteoarthritis and Cartilage, 22, 1-22.
El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014). Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone, 59, 151-161. [More Information]
Riordan, E., Little, C., Hunter, D. (2014). Pathogenesis of post-traumatic OA with a view to intervention. Best Practice & Research: Clinical Rheumatology, 28(1), 17-30. [More Information]
Chan, B., Zaki, S., Smith, S., Little, C., Purves, R. (2014). SHORT BUT NOT LONG TERM SCLEROSTIN INHIBITION WORSENS POST-TRAUMATIC OSTEOARTHRITIS IN MICE. Osteoarthritis and Cartilage, 22, 1-2.
Koenig, T., Dart, A., Mcllwraith, C., Horadagoda, N., Bell, R., Perkins, N., Dart, C., Krockenberger, M., Jeffcott, L., Little, C. (2014). Treatment of Experimentally Induced Osteoarthritis in Horses Using Intravenous Combination of sodium Pentosan Polysulfate, N-Acetyl Glucosamine, and Sodium Hyaluronan. Veterinary Surgery, 43(5), 612-622. [More Information]
Malfait, A., Little, C., Dougall, J. (2013). A commentary on modelling osteoarthritis pain in small animals. Osteoarthritis and Cartilage, 21(9), 1316-1326. [More Information]
Smith, M., Russell, A., Schiavinato, A., Little, C. (2013). A hexadecylamide derivative of hyaluronan (HYMOVIS(R)) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronan. Journal of Inflammation, 10(1), 1-16. [More Information]
Melrose, J., Smith, M., Smith, S., Ravi, V., Young, A., Dart, A., Sonnabend, D., Little, C. (2013). Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy. Tissue and Cell, 45(1), 77-82. [More Information]
Shu, C., Smith, S., Little, C., Melrose, J. (2013). Comparative immunolocalisation of perlecan, heparan sulphate, fibroblast growth factor-18, and fibroblast growth factor receptor-3 and their prospective roles in chondrogenic and osteogenic development of the human foetal spine. European Spine Journal, 22(8), 1774-1784. [More Information]
Cake, M., Read, R., Corfield, G., Daniel, A., Burkhardt, D., Smith, M., Little, C. (2013). Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep. Osteoarthritis and Cartilage, 21(1), 226-236. [More Information]
Zaki, S., Smith, M., Smith, S., Connor, M., Little, C. (2013). Contrasting Pathophysiology and Behavioural Responses Associated With Osteoarthritis and An Inflammatory Arthropathy. Abstracts of Papers, , 1-3.
Smith, M., Ravi, V., Dart, A., Sonnabend, D., Little, C. (2013). Factors affecting tendinopathogenesis. British Journal of Sports Medicine, 47(9), 23-24. [More Information]
Smith, M., Dart, A., Little, C. (2013). Large proteoglycan metabolism in tendinopathy. British Journal of Sports Medicine, 47, 29-29.
Smith, M., Jacobson, E., Dart, A., Little, C. (2013). Large proteoglycan metabolism in tendinopathy. British Journal of Sports Medicine, 47(9), e2. [More Information]
Belluoccio, D., Rowley, L., Little, C., Bateman, J. (2013). Maintaining mRNA integrity during decalcification of mineralized tissues. PloS One, 8(3), 1-6. [More Information]
Little, C., Hunter, D. (2013). Post-traumatic osteoarthritis: from mouse models to clinical trials. Nature Reviews Rheumatology, 9(8), 485-497. [More Information]
Jackson, M., Moradi, B., Smith, S., Jackson, C., Little, C. (2013). Protease activated receptor-2 but not PAR-1, modulates synovial macrophage maturation in post-traumatic OA. Osteoarthritis and Cartilage, 21, S61.
Gossan, N., Zeef, L., Hensman, J., Hughes, A., Bateman, J., Rowley, L., Little, C., Piggins, H., Rattray, M., Boot-Handford, R., et al (2013). The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis. Arthritis & Rheumatology, 65(9), 2334-2345. [More Information]
Shu, C., Hughes, C., Smith, S., Smith, M., Hayes, A., Caterson, B., Little, C., Melrose, J. (2013). The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc. Glycoconjugate Journal, 30(7), 717-725. [More Information]
Bateman, J., Rowley, L., Belluoccio, D., Chan, B., Bell, K., Fosang, A., Little, C. (2013). Transcriptomics of Wild-Type Mice and Mice Lacking ADAMTS-5 Activity Identifies Genes Involved in Osteoarthritis Initiation and Cartilage Destruction. Arthritis & Rheumatology, 65(6), 1547-1560. [More Information]
Maher, A., Coles, C., White, J., Bateman, J., Fuller, E., Burkhardt, D., Little, C., Cake, M., Read, R., McDonagh, M., et al (2012). 1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep. Journal of Proteome Research, 11(8), 4261-4268. [More Information]
Melrose, J., Isaacs, M., Smith, S., Hughes, C., Little, C., Caterson, B., Hayes, A. (2012). Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development. Histochemistry and Cell Biology, 138(3), 461-475. [More Information]
Zaki, S., Smith, M., Smith, S., Connor, M., Little, C., Purves, R. (2012). DISTINCT PAIN MECHANISMS IN TWO DIFFERENT MODELS OF ARTHRITIS. Osteoarthritis and Cartilage, 20, 1-2.
Melrose, J., Shu, C., Young, C., Ho, R., Smith, M., Young, A., Smith, S., Gooden, B., Dart, A., Podadera, J., Appleyard, R., Little, C. (2012). Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration. Spine, 37(1), 18-25. [More Information]
Boeuf, S., Graf, F., Fischer, J., Moradi, B., Little, C., Richter, W. (2012). Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells. European Cells and Materials, 23, 320-332. [More Information]
Chan, B., Little, C. (2012). The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis. Arthritis Research and Therapy, 14(3), 119-1-119-3. [More Information]
Little, C., Zaki, S. (2012). What constitutes an "animal model of osteoarthritis" - the need for consensus ? Osteoarthritis and Cartilage, 20(4), 261-267. [More Information]
Fuller, E., Smith, M., Little, C., Melrose, J. (2012). Zonal differences in meniscus matrix turnover and cytokine response. Osteoarthritis and Cartilage, 20(1), 49-59. [More Information]
Bernardo, B., Belluoccio, D., Rowley, L., Little, C., Hansen, U., Bateman, J. (2011). Cartilage Intermediate Layer Protein 2 (CILP-2) Is Expressed in Articular and Meniscal Cartilage and Down-regulated in Experimental Osteoarthritis. Journal of Biological Chemistry, 286(43), 37758-37767. [More Information]
Chan, B., Fuller, E., Russell, A., Smith, S., Smith, M., Jackson, M., Cake, M., Read, R., Bateman, J., Sambrook, P., Little, C. (2011). Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis and Cartilage, 19(7), 874-885. [More Information]
Stanton, H., Golub, S., Rogerson, F., Last, K., Little, C., Fosang, A. (2011). Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage. Nature Protocols, 6(3), 388-404. [More Information]
Lamande, S., Yuan, Y., Gresshoff, I., Rowley, L., Belluoccio, D., Kaluarachchi, K., Little, C., Botzenhart, E., Zerres, K., Amor, D., et al (2011). Mutations in TRPV4 cause an inherited arthropathy of hands and feet. Nature Genetics, 43(11), 1142-1146. [More Information]
Stanton, H., Melrose, J., Little, C., Fosang, A. (2011). Proteoglycan degradation by the ADAMTS family of proteinases. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1812 (12), 1616-1629. [More Information]
Glasson, S., Little, C. (2011). The recent paper "Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilization of the medial meniscus and increased joint laxity". Osteoarthritis and Cartilage, 19(8), 1076-1077. [More Information]
Schollum, M., Appleyard, R., Little, C., Melrose, J. (2010). A Detailed Microscopic Examination of Alterations in Normal Anular Structure Induced by Mechanical Destabilization in an Ovine Model of Disc Degeneration. Spine, 35(22), 1965-1973. [More Information]
Nguyen, T., Little, C., Yenson, V., Jackson, C., McCracken, S., Warning, J., Stevens, V., Gallery, E., Morris, J. (2010). Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance. Journal of Autoimmunity, 35(1), 86-97. [More Information]
Aigner, T., Cook, J., Gerwin, N., Glasson, S., Laverty, S., Little, C., McIlwraith, W., Kraus, V. (2010). Histopathology atlas of animal model systems - overview of guiding principles. Osteoarthritis and Cartilage, 18(SUPPL. 3), S2-S6. [More Information]
Melrose, J., Little, C. (2010). Immunolocalization of lymphatic vessels in human fetal knee joint tissues. Connective Tissue Research, 51(4), 289-305. [More Information]
Little, C., Fosang, A. (2010). Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis - insights from studies of aggrecan and collagen proteolysis? Current Drug Targets, 11(5), 561-575. [More Information]
Fosang, A., Last, K., Stanton, H., Golub, S., Little, C., Brown, L., Jackson, D. (2010). Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan. Methods in Molecular Biology (Clifton N.J.), 622, 312-47. [More Information]
Jackson, M., Smith, M., Smith, S., Jackson, C., Little, C. (2010). Protease activated receptor-2 and activated protein C in cartilage degradation. Osteoarthritis and Cartilage, 18(S2), S90-S90.
Zreiqat, H., Belluoccio, D., Smith, M., Wilson, R., Rowley, L., Jones, K., Ramaswamy, Y., Vogl, T., Roth, J., Bateman, J., Little, C. (2010). S100A8 and S100A9 in experimental osteoarthritis. Arthritis Research and Therapy, 12(1), 1-13. [More Information]
Little, C., Kim, Y. (2010). Targeting Cartilage Breakdown in Osteoarthritis. Journal of American Academy of Orthopaedic Surgeons, 18(4), 243-246.
Little, C., Smith, M., Cake, M., Read, R., Murphy, M., Barry, F. (2010). The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats. Osteoarthritis and Cartilage, 18(Suppl 3), S80-S92. [More Information]
Little, C. (2010). The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis and Cartilage, 18(3), S17-23. [More Information]
Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009). Activated protein C mediates a healing phenotype in cultured tenocytes. Journal of Cellular and Molecular Medicine, 13(4), 749-757. [More Information]
Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009). Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthritis & Rheumatology, 60(3), 780-791. [More Information]
Melrose, J., Burkhardt, D., Taylor, T., Dillon, C., Read, R., Cake, M., Little, C. (2009). Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease. European Spine Journal, 18(4), 479-489. [More Information]
Little, C., Barai, A., Burkhardt, D., Smith, S., Fosang, A., Werb, Z., Shah, M., Thompson, E. (2009). Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Care and Research, 60(12), 3723-3733. [More Information]
Smith, S., Whitelock, J., Iozzo, R., Little, C., Melrose, J. (2009). Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development. Histochemistry and Cell Biology, 132(5), 491-503. [More Information]
Little, C., Smith, M. (2008). Animal Models of Osteoarthritis. Current Rheumatology Reviews, 4(3), 175-182. [More Information]
Cake, M., Read, R., Edwards, S., Smith, M., Burkhardt, D., Little, C., Ghosh, P. (2008). Changes in gait after bilateral meniscectomy in sheep: effect of two hyaluronan preparations. Journal of Orthopaedic Science, 13(6), 514-523. [More Information]
Fosang, A., Little, C. (2008). Drug insight: aggrecanases as therapeutic targets for osteoarthritis. Nature clinical practice: Rheumatology, 4(8), 420-427. [More Information]
Fitzgerald, J., Rich, C., Burkhardt, B., Allen, J., Herzka, A., Little, C. (2008). Evidence for articular cartilage regeneration in MRL/MpJ mice. Osteoarthritis and Cartilage, 16(11), 1319-1326. [More Information]
Melrose, J., Fuller, E., Roughley, P., Smith, M., Kerr, B., Hughes, C., Caterson, B., Little, C. (2008). Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. Arthritis Research and Therapy, 10(4), 1-10. [More Information]
Gauci, S., Golub, S., Tutolo, L., Little, C., Sims, N., Lee, E., Mackie, E., Fosang, A. (2008). Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage. Journal of Musculoskeletal and Neuronal Interactions, 8(4), 308-310. [More Information]
Smith, M., Sakurai, G., Smith, S., Young, A., Melrose, J., Stewart, C., Appleyard, R., Peterson, J., Gilles, R., Dart, A., Sonnabend, D., Little, C. (2008). Modulation of Aggrecan and ADAMTS Expression in Ovine Tendinopathy Induced by Altered Strain. Seminars in Arthritis and Rheumatism, 58(4), 1055-1066. [More Information]
Melrose, J., Hayes, A., Whitelock, J., Little, C. (2008). Perlecan, the jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues.". BioEssays, 30(5), 457-469. [More Information]
Wilson, R., Belluoccio, D., Little, C., Fosang, A., Bateman, J. (2008). Proteomic characterization of mouse cartilage degradation in vitro. Seminars in Arthritis and Rheumatism, 58(10), 3120-3131. [More Information]
Melrose, J., Smith, S., Little, C., Moore, R., Vernon-Roberts, B., Fraser, R. (2008). Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies. European Spine Journal, 17(9), 1131-1148. [More Information]
Smith, M., Cake, M., Ghosh, P., Schiavinato, A., Read, R., Little, C. (2008). Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy. Rheumatology (Print Edition), 47(8), 1172-1178. [More Information]
Melrose, J., Smith, S., Smith, M., Little, C. (2008). The use of Histochoice (tmR) for histological examination of articular and growth plate cartilages, intervertebral disc and meniscus. Biotechnic and Histochemistry, 83(1), 47-53. [More Information]
Melrose, J., Smith, S., Appleyard, R., Little, C. (2007). Aggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral disc. European Spine Journal, Published online: 31 October 2007, 1-11. [More Information]
Alini, M., Eisenstein, S., Ito, K., Little, C., Kettler, A., Masuda, K., Melrose, J., Ralphs, J., Stokes, I., Wilke, H. (2007). Are animal models useful for studying human disc disorders/degeneration? European Spine Journal, Published online: 14 July 2007(0), 1-18. [More Information]
Melrose, J., Smith, S., Fuller, E., Young, A., Roughley, P., Dart, A., Little, C. (2007). Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs. European Spine Journal, 16(12), 2193-2205. [More Information]
Little, C., Meeker, C., Golub, S., Lawlor, K., Farmer, P., Smith, S., Fosang, A. (2007). Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. Journal of Clinical Investigation, 117(6), 1627-1636. [More Information]
Young, A., Appleyard, R., Smith, M., Melrose, J., Little, C. (2007). Dynamic Biomechanics Correlate With Histopathology in Human Tibial Cartilage: A Preliminary Study. Clinical Orthopaedics and Related Research, 462, 212-220. [More Information]
Powell, A., Little, C., Hughes, C. (2007). Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system. Arthritis & Rheumatology, 56(9), 3010-3019. [More Information]
Young, A., McLennan, S., Smith, M., Smith, S., Cake, M., Read, R., Melrose, J., Sonnabend, D., Flannery, C., Little, C. (2006). Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Research and Therapy, 8(2), 1-6. [More Information]
Little, C., Mittaz, L., Belluoccio, D., Rogerson, F., Campbell, I., Meeker, C., Bateman, J., Pritchard, M., Fosang, A. (2005). ADAMTS-1 knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo. Arthritis & Rheumatology, 52(5), 1461-1472. [More Information]
Stanton, H., Rogerson, F., East, C., Golub, S., Lawlor, K., Meeker, C., Little, C., Last, K., Farmer, P., Campbell, I., et al (2005). ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature, 434(7033), 648-652. [More Information]
Fosang, A., Little, C., Meeker, C. (2005). Aggrecan knock-in mice are resistant to proteolysis by MMP or ADAMTS enzymes in the interglobular domain. Scandinavian Journal of Rheumatology, 34, 13-14.
Little, C., Flannery, C., Hughes, C., Goodship, A., Caterson, B. (2005). Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration. Osteoarthritis and Cartilage, 13(2), 162-170. [More Information]
Little, C., Meeker, C., Fosang, A. (2005). Generation of mice with aggrecan resistant to aggrecanase cleavage in the IGD. 51st Annual Meeting of the Orthopaedic Research Society, 30, 357.
Little, C., Meeker, C., Hembry, R., Sims, N., Lawlor, K., Golub, S., Last, K., Fosang, A. (2005). Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development. Molecular and Cellular Biology, 25(8), 3388-3399. [More Information]
Young, A., Smith, M., Smith, S., Burkhardt, D., Cake, M., Melrose, J., Read, R., Ghosh, P., Sonnabend, D., Little, C. (2005). Metabolism of Small Leucine-Rich Proteoglycans in an Ovine Model of Osteoarthritis. 51st Annual Meeting of the Orthopaedic Research Society, 30, 1057-1057.
Innes, J., Little, C., Hughes,, C., Caterson, B. (2005). Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early-and late-stage osteoarthritis. American Journal of Veterinary Research, 66(10), 1679-1685. [More Information]
Yang, Y., Hall, P., Little, C., Fosang, A., Milenkovski, G., Santos, L., Xue, J., Tipping, P., Morand, E. (2005). Reduction of Arthritis Severity in Protease-Activated Receptorâ€“Deficient Mice. Arthritis & Rheumatology, 52(4), 1325-1332. [More Information]
Young, A., Smith, M., Smith, S., Cake, M., Ghosh, P., Read, R., Melrose, J., Sonnabend, D., Roughley, P., Little, C. (2005). Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. Arthritis Research and Therapy, 7(4), R852-61. [More Information]
Janusz, M., Little, C., King, L., Hookfin, E., Brown, K., Heitmeyer, S., Caterson, B., Poole, A., Taiwo, Y. (2004). Detection of aggrecanase and MMP-generated catabolic neoepitopes in the rat iodacetate model of cartilage degeneration. Osteoarthritis and Cartilage, 12(9), 720-728. [More Information]
Hughes, C., Little, C., Caterson, B. (2003). Measurement of aggrecanase-generated interglobular domain catabolites in the medium and extracts of cartilage explants using Western blot analysis. Methods in Molecular Biology, 225(-), 89-98.
Fosang, A., Stanton, H., Little, C., Atley, L. (2003). Neoepitopes as Biomarkers of Cartilage Catabolism. Inflammation Research, 52(7), 277-282. [More Information]
Dart, A., Little, C., Hughes, C., Chu, Q., Dowling, B., Hodgson, D., Rose, R., Johnson, K. (2003). Recombinant equine growth hormone administration: effects on synovial fluid biomarkers and cartilage metabolism in horses. Equine Veterinary Journal, 35(3), 302-307.
Little, C., Hughes, C., Curtis, C., Jones, S., Caterson, B., Flannery, C. (2002). Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage. Arthritis & Rheumatology, 46(1), 124-129.
Little, C., Hughes, C., Curtis, C., Janusz, M., Bohne, R., Wang-Weigand, S., Taiwo, Y., Mitchell, P., Otterness, I., Flannery, C., et al (2002). Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Matrix Biology, 21(3), 271-288. [More Information]
Melrose, J., Smith, S., Little, C., Kitson, J., Hwa, S., Ghosh, P. (2002). Spatial and temporal localization of transforming growth factor-b, fibroblast growth factor-2, and osteonectin, and identification of cells expressing a-smooth muscle actin in the injured annulus fibrosus. Implications for extracellular matrix repair. Spine, 27(16), 1756-1764. [More Information]
Hwa, S., Burkhardt, D., Little, C., Ghosh, P. (2001). The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis. Journal of Rheumatology, 28(4), 825-834.

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Conferences

Melrose, J., Gooden, B., Dart, A., Appleyard, R., Little, C. (2009). Dysregulation of metalloproteinase expression in a mechanical destabilization model of intervertebral disc degeneration in sheep. ACSR Spinal Research Symposium VII.
Dart, A., Little, C. (2009). Focal injury induces widespread pathology in equine superficial digital flexor tendons. 31st Bain Fallon Lectures, Australia.
Jacobson, E., Smith, M., Mondori, T., Smith, S., Dart, A., Little, C. (2008). Focal injury induces widespread pathology in equine superficial digital flexor tendons. Matrix Biology Society of Australia and New Zealand Annual Meeting MBSANZ 2008, Australia: Matrix Biology Society of Australia and New Zealand.
Smith, M., Smith, S., Kikukawa, K., Dart, A., Sonnabend, D., Little, C. (2008). Spacio-temporal changes in pathology and proteoglycan gene expression in shoulder tendons induced by overstress or stress deprivation. Matrix Biology Society of Australia and New Zealand Annual Meeting MBSANZ 2008, Australia: Matrix Biology Society of Australia and New Zealand.
Melrose, J., Smith, S., Fuller, E., Young, A., Roughley, P., Dart, A., Little, C. (2008). Spatial and temporal catabolism of the small leucine repeat proteoglycans (SLRPs) in an ovine annular lesion model of experimental intervertebral disc degeneration has structure-function implications. World Forum for Spine Research 2008, Switzerland: AO Foundation.
Smith, M., Smith, S., Kikukawa, K., Dart, A., Sonnabend, D., Little, C. (2008). Temporal change in proteoglycan gene expression and histopathology induced in sheep shoulder tendons by altered stress in vivo. Osteoarthritis Research Society International World Congress on Osteoarthritis OARSI 2008, United States: Osteoarthritis Research Society International.
Smith, M., Sakurai, A., Smith, S., Young, A., Melrose, J., Dart, A., Sonnabend, D., Little, C. (2006). Altered aggrecan and ADAMTS expression in overload-induced tendon pathology. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Young, A., McLennan, S., Smith, S., Smith, M., Melrose, J., Cake, M., Flannery, C., Sonnabend, D., Little, C. (2006). Changes in expression and immunolcalization of proteoglycan 4 / lubricin in cartilage in an ovine model of early osteoarthritis. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Little, C., Jackson, M., Smith, M., Burkhardt, D., Xue, M., Jackson, C. (2006). Potential role of activated protein C (APC) in articular cartilage degeneration. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Stewart, M., Fosang, A., Little, C., Sandy, J. (2005). A murine epiphyseal chondrocyte model of ADAMTS 5-mediated aggrecanolysis. 2005 Annual Meeting Of The American Society for Bone and Mineral Research, United States: American Society for Bone and Mineral Research.
Stanton, H., East, C., Golub, S., Rogerson, F., Lawlor, K., Little, C., Fosang, A. (2005). ADAMTS-5 is the major aggrecanase in cartilage: in vitro studies with ADAMTS-4 and ADAMTS-5 deficient mice. 51st Annual Meeting of Orthopaedic Research Society, USA: Orthopaedic Research Society.
Little, C., Meeker, C., Fosang, A. (2005). Generation of mice with aggrecan resistant to aggrecanase cleavage in the IGD. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Little, C., Mittaz, L., Meeker, C., Pritchard, M., Fosang, A. (2004). ADAMTS-1 knockout mice do not exhibit abnormalities in aggrecan turnover in-vivo or in-vitro. 50th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
Little, C., Curtis, C., Cramp, J., Vaughn-Thomas, A., Harwood, J., Innes, J., Caterson, B. (2004). Differential effects of canine cartilage to cytokine stimulation and n-3 polyunsaturated fatty acids supplementation versus human and bovine cartilage. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Little, C., Cramp, J., Curtis, C., Richardson, D., Schoenherr, B., Innes, J., Jones, S., Caterson, B. (2003). Canine articular catilage degradation: The role of catabolic cytokines. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Jones, A., Hughes, C., Wainwright, S., Flannery, C., Little, C., Caterson, B. (2003). Degradation of PRG4/SZP by Matrix Proteases. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Little, C., Meeker, C., Fosang, A. (2003). Degradative mechanisms in mouse articular cartilage:use of in vitro models to analyse proteolysis and loss of aggrecan and link protein. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Rees, A., Hughes, C., Little, C., Caterson, B. (2003). Evidence for zymogen forms of aggrecanase-1 (ADAMTS-4) in chondrocyte-agarose cultures. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Little, C., Flannery, C., Hughes, C., Precious, G., Otterness, I., Goodship, A., Caterson, B. (2002). Cytokine induced metalloproteinase expression and activity does not correlate with focal cartilage pathology. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
Little, C., Roughley, P., Otterness, I., Hughes, C., Caterson, B. (2002). Hiearchical catabolism of collagen associated proteoglycans in in vitro models of progressive articular cartilage degradation. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
Curtis, C., Rees, S., Little, C., Flannery, C., Hughes, C., Dent, C., Wilson, C., Harwood, J., Caterson, B. (2002). N-3 fatty acid supplementation specifically ablates the activity and expression of aggrecanases and inflammatory mediators in human osteoarthritic cartilage. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
Curtis, C., Little, C., Rees, S., Flannery, C., Hughes, C., Otterness, I., Dent, C., Harwood, J., Caterson, B. (2002). N-3 fatty acids inhibit expression and activity of MMPs in human osteoarthritic cartilage. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
Little, C., Otterness, I., Hughes, C., Caterson, B. (2002). Proteolysis of type IX collagen and loss of biglycan, decorin and fibromodulin in progressive articual cartilage degradation. Oesteoarthritis and Cartilage.
Davies, J., Rees, A., Hughes, C., Little, C., Caterson, B. (2001). An immunohistochemical study of aggrecan catabolism in porcine articular cartilage. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
Diffin, F., Little, C., Elson, C., Westacott, C. (2001). Catabolism of aggrecan by cells derived from osteoarthritic bone. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
Flannery, C., Little, C., Hughes, C., Curtis, C., Caterson, B. (2001). Cyclosporin A inhibits IL-1-induced aggrecanase-mediated proteoglycan catabolism in situ in articular cartilage. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
Flannery, C., Little, C., Hughes, C., Curtis, C., Jones, S., Caterson, B. (2001). IL-6 and its soluable receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
Melrose, J., Smith, S., Little, C., Kitson,, J., Hwa, S., Ghosh, P. (2001). Repair of annular disc lesions: Spatial and temporal localisation of TGF-beta, SPARC (Osteonectin, BM-40) and FGF-2 are early responses in experimentally injured ovine discs. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
Little, C., Flannery, C., Hughes, C., Otterness, I., Caterson, B. (2001). Species specificity of neopitope antibodies to aggrecanase- and MMP- generated sequences in the interglobular domain of aggrecan. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
Little, C., Hughes, C., Otterness, I., Janusz, M., Caterson, B. (2001). The role of matrix metalloproteinases in c-terminal catabolism of aggrecan. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.

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By Year

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2024

Obeidat, A., Malfait, A., Scanzello, C., Kim, S., Burt, K., Hu, B., Li, J., Ishihara, S., Xiao, R., Miller, R., Little, C. (2024). A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis. Osteoarthritis and Cartilage. [More Information]

2023

Alini, M., Diwan, A., Erwin, W., Little, C., Melrose, J. (2023). An update on animal models of intervertebral disc degeneration and low back pain: Exploring the potential of artificial intelligence to improve research analysis and development of prospective therapeutics. JOR Spine, 6(1). [More Information]
Ashton, D., Blaker, C., Hartnell, N., Haubruck, P., Hefferan, S., Little, C., Clarke, E. (2023). Challenging the Perceptions of Human Tendon Allografts: Influence of Donor Age, Sex, Height, and Tendon on Biomechanical Properties. The American Journal of Sports Medicine, 51(3), 768-778. [More Information]
Macfarlane, E., Cavanagh, L., Fong-Yee, C., Tuckermann, J., Chen, D., Little, C., Seibel, M., Zhou, H. (2023). Deletion of the chondrocyte glucocorticoid receptor attenuates cartilage degradation through suppression of early synovial activation in murine posttraumatic osteoarthritis. Osteoarthritis and Cartilage, 31(9), 1189-1201. [More Information]
Julovi, S., Dao, A., Trinh, K., O'Donohue, A., Shu, C., Smith, S., Shingde, M., Schindeler, A., Rogers, N., Little, C. (2023). Disease-modifying interactions between chronic kidney disease and osteoarthritis: A new comorbid mouse model. RMD Open, 9(3). [More Information]
Ng, J., Jafarov, T., Little, C., Wang, T., Ali, A., Ma, Y., Radford, G., Vrbanac, L., Ichinose, M., Hunter, D., et al (2023). Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis. Nature Communications, 14(1), 6909. [More Information]
Chen, R., Pye, J., Li, J., Little, C., Li, J. (2023). Multiphasic scaffolds for the repair of osteochondral defects: Outcomes of preclinical studies. Bioactive Materials, 27, 505-545. [More Information]

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2022

Little, C., Zaki, S., Blaker, C., Clarke, E. (2022). Animal models of osteoarthritis. The Bone and Joint Journal, 11(8), 514-517. [More Information]
de Luca, K., Chiarotto, A., Cicuttini, F., Creemers, L., de Schepper, E., Ferreira, P., Foster, N., Hartvigsen, J., Kawchuk, G., Little, C., Ferreira, M., et al (2022). Consensus for statements regarding a definition for spinal osteoarthritis for use in research and clinical practice: A Delphi study. Arthritis Care and Research. [More Information]
Tran, T., Mach, J., Gemikonakli, G., Wu, H., Allore, H., Howlett, S., Little, C., Hilmer, S. (2022). Diurnal effects of polypharmacy with high drug burden index on physical activities over 23Â h differ with age and sex. Scientific Reports, 12(1), 2168. [More Information]
Lim, Y., Wang, Y., Estee, M., Abidi, J., Udaya Kumar, M., Hussain, S., Wluka, A., Little, C., Cicuttini, F. (2022). Metformin as a potential disease-modifying drug in osteoarthritis: a systematic review of pre-clinical and human studies. Osteoarthritis and Cartilage, 30(11), 1434-1442. [More Information]
James, G., Stecco, C., Blomster, L., Hall, L., Schmid, A., Shu, C., Little, C., Melrose, J., Hodges, P. (2022). Muscle spindles of the multifidus muscle undergo structural change after intervertebral disc degeneration. European Spine Journal, 31(7), 1879-1888. [More Information]
Zaki, S., Baker, C., Little, C. (2022). OA foundations – experimental models of osteoarthritis. Osteoarthritis and Cartilage, 30(3), 357-380. [More Information]
Vincent, T., Alliston, T., Kapoor, M., Loeser, R., Troeberg, L., Little, C. (2022). Osteoarthritis Pathophysiology: Therapeutic Target Discovery may Require a Multifaceted Approach. Clinics in Geriatric Medicine, 38(2), 193-219. [More Information]
Clement-Lacroix, P., Little, C., Smith, M., Cottereaux, C., Merciris, D., Meurisse, S., Mollat, P., Touitou, R., Brebion, F., Gosmini, R., et al (2022). Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5. Osteoarthritis and Cartilage, 30(2), 291-301. [More Information]

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2021

Liu, X., Robbins (nee: Ferreira De Meneses), S., Wang, X., Virk, S., Schuck, K., Miranda Alle Deveza, L., Oo, W., Carmichael, K., Antony, B., Eckstein, F., Little, C., O'Connell, R., Heller, G., Hunter, D., et al (2021). Efficacy and cost-effectiveness of Stem Cell injections for symptomatic relief and strUctural improvement in people with Tibiofemoral knee OsteoaRthritis: Protocol for a randomised placebo-controlled trial (the SCUlpTOR trial). BMJ Open, 11(11), e056382. [More Information]
Duong, V., Bennell, K., Clifton-Bligh, R., Miranda Alle Deveza, L., Elliott, J., Guilak, F., Hall, M., Henderson, L., Hodges, P., Johnstone, B., Little, C., Raviraj, V., Yu, S., Zaki, S., Hunter, D., et al (2021). Exploring translational gaps between basic scientists, clinical researchers, clinicians, and consumers: Proceedings and recommendations arising from the 2020 mine the gap online workshop. Osteoarthritis and Cartilage Open, 3(2), 100163. [More Information]
Ryan, S., Hosseini Beheshti, E., Afrose, D., Ding, X., Xia, B., Grau, G., Little, C., McClements, L., Li, J. (2021). Extracellular vesicles from mesenchymal stromal cells for the treatment of inflammation-related conditions. International Journal of Molecular Sciences, 22(6), 1-34. [More Information]
Kung, L., Sampurno, L., Little, C., Lamande, S., Bateman, J. (2021). Generation of a miR-26b stem-loop knockout human iPSC line, MCRIi019-A-1, using CRISPR/Cas9 editing. Stem Cell Research, 50, 1-5. [More Information]
Sammel, A., Xue, M., Karsten, E., Little, C., Smith, S., Nguyen, K., Laurent, R. (2021). Limited utility of novel serological biomarkers in patients newly suspected of having giant cell arteritis. International Journal of Rheumatic Diseases, 24(6), 781-788. [More Information]
Blaker, C., Zaki, S., Little, C., Clarke, E. (2021). Long-term Effect of a Single Subcritical Knee Injury: Increasing the Risk of Anterior Cruciate Ligament Rupture and Osteoarthritis. The American Journal of Sports Medicine, 49(2), 391-403. [More Information]
Tran, T., Mach, J., Gemikonakli, G., Wu, H., Allore, H., Howlett, S., Little, C., Hilmer, S. (2021). Male-Female Differences in the Effects of Age on Performance Measures Recorded for 23 Hours in Mice. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 76(12), 2141-2146. [More Information]
Haubruck, P., Pinto, M., Moradi, B., Little, C., Gentek, R. (2021). Monocytes, Macrophages, and Their Potential Niches in Synovial Joints – Therapeutic Targets in Post-Traumatic Osteoarthritis? Frontiers in Immunology, 12, 763702. [More Information]
Soul, J., Barter, M., Little, C., Young, D. (2021). OATargets: A knowledge base of genes associated with osteoarthritis joint damage in animals. Annals of the Rheumatic Diseases, 80(3), 376-383. [More Information]
Zaki, S., Smith, M., Little, C. (2021). Pathology-pain relationships in different osteoarthritis animal model phenotypes: it matters what you measure, when you measure, and how you got there. Osteoarthritis and Cartilage, 29(10), 1448-1461. [More Information]
Roos, E., Risberg, M., Little, C. (2021). Prevention and early treatment, a future focus for OA research. Osteoarthritis and Cartilage, 29(12), 1627-1629. [More Information]
Blaker, C., Ashton, D., Little, C., Clarke, E., Doran, N. (2021). Sex- and injury-based differences in knee biomechanics in mouse models of post-traumatic osteoarthritis. Journal of Biomechanics, 114, 110152-1-110152-10. [More Information]
Oo, W., Little, C., Duong, V., Hunter, D. (2021). The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date. Drug Design, Development and Therapy, 15, 2921-2945. [More Information]

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2020

Van Spil, W., Bierma-Zeinstra, S., Miranda Alle Deveza, L., Arden, N., Bay-Jensen, A., Kraus, V., Carlesso, L., Christensen, R., van der Esch, M., Kent, P., Little, C., Hunter, D., et al (2020). A consensus-based framework for conducting and reporting osteoarthritis phenotype research. Arthritis Research and Therapy, 22(1), 54. [More Information]
Sammel, A., Smith, S., Nguyen, K., Laurent, R., Brewer, J., Hall, N., Little, C. (2020). Assessment for varicella zoster virus in patients newly suspected of having giant cell arteritis. Rheumatology, 59(8), 1992-1996. [More Information]
Zaki, S., Smith, M., Smith, S., Little, C. (2020). Differential patterns of pathology in and interaction between joint tissues in long-term osteoarthritis with different initiating causes: phenotype matters. Osteoarthritis and Cartilage, 28(7), 953-965. [More Information]
Haubruck, P., Colbath, A., Liu, Y., Stoner, S., Shu, C., Little, C. (2020). Flow cytometry analysis of immune cell subsets within the murine spleen, bone marrow, lymph nodes and synovial tissue in an osteoarthritis model. Journal of Visualized Experiments, 2020 (158), e61008. [More Information]
Roelofs, A., Kania, K., Rafipay, A., Sambale, M., Kuwahara, S., Collins, F., Smeeton, J., Serowoky, M., Rowley, L., Wang, H., Little, C., et al (2020). Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis. Annals of the Rheumatic Diseases, 79(12), 1625-1634. [More Information]
Ng, J., Little, C., Woods, S., Whittle, S., Lee, F., Gronthos, S., Mukherjee, S., Hunter, D., Worthley, D. (2020). Stem cell-directed therapies for osteoarthritis: The promise and the practice. Stem Cells, 38(4), 477-486. [More Information]
Shu, C., Zaki, S., Ravi, V., Schiavinato, A., Smith, M., Little, C. (2020). The relationship between synovial inflammation, structural pathology, and pain in post-traumatic osteoarthritis: differential effect of stem cell and hyaluronan treatment. Arthritis Research and Therapy, 22(29), 1-13. [More Information]

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2019

Xue, M., Dervish, S., McKelvey, K., March, L., Wang, F., Little, C., Jackson, C. (2019). Activated protein C targets immune cells and rheumatoid synovial fibroblasts to prevent inflammatory arthritis in mice. Rheumatology, 58(10), 1850-1860. [More Information]
Blaker, C., Clarke, E., Little, C. (2019). Adding Insult to Injury: synergistic effect of combining risk-factors in models of post-traumatic osteoarthritis. Osteoarthritis and Cartilage, 27(12), 1731-1734. [More Information]
Shu, C., Flannery, C., Little, C., Melrose, J. (2019). Catabolism of Fibromodulin in Developmental Rudiment and Pathologic Articular Cartilage Demonstrates Novel Roles for MMP-13 and ADAMTS-4 in C-terminal Processing of SLRPs. International Journal of Molecular Sciences, 20(3), 1-21. [More Information]
Hunter, D., Nicolson, P., Little, C., Robbins (nee: Ferreira De Meneses), S., Wang, X., Bennell, K. (2019). Developing strategic priorities in osteoarthritis research: Proceedings and recommendations arising from the 2017 Australian Osteoarthritis Summit. BMC Musculoskeletal Disorders, 20(1), 1-9. [More Information]
Gauci, S., Golub, S., Tatarczuch, L., Lee, E., Chan, D., Walsh, N., Little, C., Stanton, H., Lokmic, Z., Sims, N., et al (2019). Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs. Matrix Biology, 83, 77-96. [More Information]
Tu, J., Zhang, P., Ji, Z., Henneicke, H., Li, J., Kim, S., Swarbrick, M., Wu, Y., Little, C., Seibel, M., Zhou, H. (2019). Disruption of glucocorticoid signalling in osteoblasts attenuates age-related surgically induced osteoarthritis. Osteoarthritis and Cartilage, 27(10), 1518-1525. [More Information]
Tsang, A., Dart, A., Biasutti, S., Jeffcott, L., Smith, M., Little, C. (2019). Effects of tendon injury on uninjured regional tendons in the distal limb: An in-vivo study using an ovine tendinopathy model. PloS One, 14(4), 1-24. [More Information]
Shu, C., Smith, S., Little, C., Melrose, J. (2019). Elevated hypertrophy, growth plate maturation, glycosaminoglycan deposition, and exostosis formation in the Hspg2 exon 3 null mouse intervertebral disc. Biochemical Journal, 476(2), 225-243. [More Information]
Choi, R., Smith, M., Smith, S., Little, C., Clarke, E. (2019). Functionally distinct tendons have different biomechanical, biochemical and histological responses to in vitro unloading. Journal of Biomechanics, 95, 1-10. [More Information]
Sulistio, A., Mansfeld, F., Reyes-Ortega, F., D'Souza, A., Ng, S., Birkett, S., Blencowe, A., Qiao, G., Little, C., Shu, C., et al (2019). Intra-articular Treatment of Osteoarthritis with Diclofenac-Conjugated Polymer Reduces Inflammation and Pain. ACS Applied Bio Materials, 2(7), 2822-2832. [More Information]
Li, J., Hosseini Beheshti, E., Grau, G., Zreiqat, H., Little, C. (2019). Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis. Nanomaterials, 9(2), 1-21. [More Information]

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2018

Shu, C., Smith, M., Appleyard, R., Little, C., Melrose, J. (2018). Achilles and tail tendons of perlecan exon 3 null heparan sulphate deficient mice display surprising improvement in tendon tensile properties and altered collagen fibril organisation compared to C57BL/6 wild type mice. PeerJ, 6, 1-25. [More Information]
McIlwraith, C., Kawcak, C., Frisbie, D., Little, C., Clegg, P., Peffers, M., Karsdal, M., Ekman, S., Laverty, S., Slayden, R., et al (2018). Biomarkers for equine joint injury and osteoarthritis. Journal of Orthopaedic Research, 36(3), 823-831. [More Information]
Kung, L., Ravi, V., Rowley, L., Angelucci, C., Fosang, A., Bell, K., Little, C., Bateman, J. (2018). Cartilage microRNA dysregulation during the onset and progression of mouse osteoarthritis is independent of aggrecanolysis and overlaps with candidates from end-stage human disease. Arthritis & Rheumatology, 70(3), 383-395. [More Information]
Brown, S., Matta, A., Erwin, M., Roberts, S., Gruber, H., Hanley, E., Little, C., Melrose, J. (2018). Cell clusters are indicative of stem cell activity in the degenerate intervertebral disc: can their properties be manipulated to improve intrinsic repair of the disc? Stem Cells and Development, 27(3), 147-165. [More Information]
Choi, R., Smith, M., Clarke, E., Little, C. (2018). Cellular, matrix, and mechano-biological differences in load-bearing versus positional tendons throughout development and aging: a narrative review. Connective Tissue Research, 59(5), 483-494. [More Information]
Zaki, S., Little, C. (2018). DEFINING THE PREDICTIVE UTILITY OF THE MOUSE DMM MODEL OF OSTEOARTHRITIS FOR TESTING/DEVELOPING THERAPEUTIC AGENTS. Osteoarthritis and Cartilage, 26, 1-1.
Shu, C., Dart, A., Bell, R., Dart, C., Clarke, E., Smith, M., Little, C., Melrose, J. (2018). Efficacy of Administered Mesenchymal Stem Cells in The Initiation and Co-ordination of Repair Processes By Resident Disc Cells In An Ovine (Ovis aries) Large Destabilizing Lesion Model of Experimental Disc Degeneration. JOR Spine, 1(4), 1-24. [More Information]
Fuller, E., Shu, C., Smith, M., Little, C., Melrose, J. (2018). Hyaluronan oligosaccharides stimulate matrix metalloproteinase and anabolic gene expression in vitro by intervertebral disc cells and annular repair in vivo. Journal of Tissue Engineering and Regenerative Medicine, 12(1), e216-e226. [More Information]
de Kroon, L., van den Akker, G., Brachvogel, B., Narcisi, R., Belluoccio, D., Jenner, F., Bateman, J., Little, C., Brama, P., Blaney Davidson, E., et al (2018). Identification of TGF(beta)-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets. Bone, 116, 67-77. [More Information]
James, G., Sluka, K., Blomster, L., Hall, L., Schmid, A., Shu, C., Little, C., Melrose, J., Hodges, P. (2018). Macrophage polarization contributes to local inflammation and structural change in the multifidus muscle after intervertebral disc injury. European Spine Journal, 27(8), 1744-1756. [More Information]
Angelo, D., Morouco, P., Gil, F., Monico, L., Gonzalez-Garcia, R., Sousa, R., Neto, L., Caldeira, I., Smith, M., Smith, S., Little, C., et al (2018). Preclinical randomized controlled trial of bilateral discectomy versus bilateral discopexy in Black Merino sheep temporomandibular joint: TEMPOJIMS - Phase 1- histologic, imaging and body weight results. Journal of Cranio-Maxillofacial Surgery, 46(4), 688-696. [More Information]
Urban, H., Little, C. (2018). The role of fat and inflammation in the pathogenesis and management of osteoarthritis. Rheumatology, 57(suppl_4), iv10-iv21. [More Information]

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2017

Shu, C., Smith, M., Smith, S., Dart, A., Little, C., Melrose, J. (2017). A Histopathological Scheme for the Quantitative Scoring of Intervertebral Disc Degeneration and the Therapeutic Utility of Adult Mesenchymal Stem Cells for Intervertebral Disc Regeneration. International Journal of Molecular Sciences, 18(5), 1-31. [More Information]
Angelo, D., Monje, F., Gonzalez-Garcia, R., Little, C., Monico, L., Pinho, M., Santos, F., Carrapico, B., Goncalves, S., Morouco, P., et al (2017). Bioengineered Temporomandibular Joint Disk Implants: Study Protocol for a Two-Phase Exploratory Randomized Preclinical Pilot Trial in 18 Black Merino Sheep (TEMPOJIMS). Journal of Medical Internet Research, 6(3), 1-10. [More Information]
Kung, L., Ravi, V., Rowley, L., Bell, K., Little, C., Bateman, J. (2017). Comprehensive Expression Analysis of microRNAs and mRNAs in Synovial Tissue from a Mouse Model of Early Post-Traumatic Osteoarthritis. Scientific Reports, 7(1), 1-12. [More Information]
Smith, M., Clarke, E., Little, C. (2017). Considerations for the Design and Execution of Protocols for Animal Research and Treatment to improve reproducibility and standardization: "DEPART well-prepared and ARRIVE safely". Osteoarthritis and Cartilage, 25(3), 354-363. [More Information]
Blaker, C., Little, C., Clarke, E. (2017). Joint loads resulting in ACL rupture: Effects of age, sex, and body mass on injury load and mode of failure in a mouse model. Journal of Orthopaedic Research, 35(8), 1754-1763. [More Information]
Gauci, S., Stanton, H., Little, C., Fosang, A. (2017). Proteoglycan and Collagen Degradation in Osteoarthritis. In Susanne Grassel, Attila Aszodi (Eds.), Cartilage: Volume 2: Pathophysiology, (pp. 41-61). Cham: Springer International Publishing. [More Information]
Biasutti, S., Dart, A., Smith, M., Blaker, C., Clarke, E., Jeffcott, L., Little, C. (2017). Spatiotemporal variations in gene expression, histology and biomechanics in an ovine model of tendinopathy. PloS One, 12(10), 1-36. [More Information]
Melrose, J., Fuller, E., Little, C. (2017). The biology of meniscal pathology in osteoarthritis and its contribution to joint disease: beyond simple mechanics. Connective Tissue Research, 58(3-4), 282-294. [More Information]
Blaker, C., Clarke, E., Little, C. (2017). Using mouse models to investigate the pathophysiology, treatment, and prevention of post-traumatic osteoarthritis. Journal of Orthopaedic Research, 35(3), 424-439. [More Information]
Kung, L., Zaki, S., Ravi, V., Rowley, L., Smith, M., Bell, K., Bateman, J., Little, C. (2017). Utility of circulating serum miRNAs as biomarkers of early cartilage degeneration in animal models of post-traumatic osteoarthritis and inflammatory arthritis. Osteoarthritis and Cartilage, 25(3), 426-434. [More Information]

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2016

Shu, C., Jackson, M., Smith, M., Smith, S., Penm, S., Lord, M., Whitelock, J., Little, C., Melrose, J. (2016). Ablation of Perlecan domain I heparan sulfate reduces progressive cartilage degradation, synovitis, and osteophyte size in post-traumatic osteoarthritis. Arthritis & Rheumatology, 68(4), 868-879. [More Information]
Choi, R., Smith, M., Martin, J., Clarke, J., Dart, A., Little, C., Clarke, E. (2016). Chondroitin sulphate glycosaminoglycans contribute to widespread inferior biomechanics in tendon after focal injury. Journal of Biomechanics, 49, 2694-2701. [More Information]
Jackson, M., Zaki, S., Ravi, V., Babak, M., Smith, S., Fosang, A., Little, C. (2016). Defining the relationship between joint pathology and pain in osteoarthritis using genetically modified mice. Osteoarthritis and Cartilage, 24, S9-S10.
Bischofberger, A., Dart, C., Horadagoda, N., Perkins, N., Jeffcott, L., Little, C., Dart, A. (2016). Effect of Manuka honey gel on the transforming growth factor β1and β3 concentrations, bacterial counts and histomorphology of contaminated full-thickness skin wounds in equine distal limbs. Australian Veterinary Journal, 94(1-2), 27-34. [More Information]
Stankoska, K., Sarram, L., Smith, S., Bedran-Russo, A., Little, C., Swain, M., Bertassoni, L. (2016). Immunolocalization and distribution of proteoglycans in carious dentine. Australian Dental Journal, 61(3), 288-297. [More Information]
Fuller, E., Little, C., Melrose, J. (2016). Interleukin-1(alpha) induces focal degradation of biglycan and tissue degeneration in an in-vitro ovine meniscal model. Experimental and Molecular Pathology, 101(2), 214-220. [More Information]
James, G., Blomster, L., Hall, L., Schmid, A., Shu, C., Little, C., Melrose, J., Hodges, P. (2016). Mesenchymal stem cell treatment of intervertebral disc lesion prevents fatty infiltration and fibrosis of the multifidus muscle, but not cytokine and muscle fiber changes. European Spine Journal, 41(15), 1208-1217. [More Information]
Hayes, A., Shu, C., Lord, M., Little, C., Whitelock, J., Melrose, J. (2016). Pericellular colocalisation and interactive properties of type VI collagen and perlecan in the intervertebral disc. European Cells and Materials, 32, 40-57. [More Information]
Markway, B., Cho, H., Anderson, D., Holden, P., Ravi, V., Little, C., Johnstone, B. (2016). Reoxygenation enhances tumour necrosis factor alpha-induced degradation of the extracellular matrix produced by chondrogenic cells. European Cells and Materials, 31, 425-439. [More Information]
Melrose, J., Smith, S., Hughes, C., Little, C., Caterson, B., Hayes, A. (2016). The 7D4, 4C3 and 3B3 (-) Chondroitin Sulphation Motifs are expressed at Sites of Cartilage and Bone Morphogenesis during Foetal Human Knee Joint Development. Journal of Glycobiology, 5(1), 1-9. [More Information]
Hayes, A., Hughes, C., Smith, S., Caterson, B., Little, C., Melrose, J. (2016). The CS Sulphation Motifs 4C3, 7D4, 3B3[-]; and Perlecan Identify Stem Cell Populations and Niches, Activated Progenitor Cells and Transitional Tissue Development in the Fetal Human Elbow. Stem Cells and Development, 25(11), 836-847. [More Information]
SHU, C., Ravindran, V., Zaki, S., Smith, S., Schiavinato, A., Smith, S., Little, C. (2016). THE EFFECTS OF INTRA-ARTICULAR INJECTION OF MESENCHYMAL STEM CELLS VERSUS HYALURONAN HEXADECYLAMIDE-DERIVATIVE ON POST-TRAUMATIC OA: THE RELATIONSHIP BETWEEN SYNOVIAL INFLAMMATION, STRUCTURAL PATHOLOGY AND PAIN SENSITISATION. Osteoarthritis and Cartilage, 24, 1-23.
Hunter, D., Little, C. (2016). The great debate: Should Osteoarthritis Research Focus on "Mice" or "Men"? Osteoarthritis and Cartilage, 24(1), 4-8. [More Information]
Bertassoni, L., Kury, M., Rathsam, C., Little, C., Swain, M. (2016). The role of proteoglycans in the nanoindentation creep behavior of human dentin. Journal of the Mechanical Behavior of Biomedical Materials, 55, 264-270. [More Information]
Shu, C., Smith, S., Little, C., Melrose, J. (2016). Use of FGF-2 and FGF-18 to direct bone marrow stromal stem cells to chondrogenic and osteogenic lineages. Future Science OA, 2(4), 1-19. [More Information]

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2015

Jacobsen, E., Dart, A., Mondori, T., Horadagoda, N., Jeffcott, L., Little, C., Smith, M. (2015). Focal experimental injury leads to widespread gene expression and histologic changes in equine flexor tendons. PloS One, 10(4), 1-25. [More Information]
Hodges, P., James, G., Blomster, L., Hall, L., Schmid, A., Shu, C., Little, C., Melrose, J. (2015). Multifidus Muscle Changes after Back Injury Are Characterized by Structural Remodeling of Muscle, Adipose and Connective Tissue, but Not Muscle Atrophy: Molecular and Morphological Evidence. Spine, 40(14), 1057-1071. [More Information]
Malfait, A., Little, C. (2015). On the predictive utility of animal models of osteoarthritis. Arthritis Research and Therapy, 17(1), 1-14. [More Information]

2014

Jackson, M., Babak, M., Smith, M., Jackson, C., Little, C. (2014). Activation of matrix metalloproteinases 2, 9, and 13 by activated protein c in human osteoarthritic cartilage chondrocytes. Arthritis & Rheumatology, 66(6), 1525-1536. [More Information]
Smith, R., McIlwraith, W., Schweitzer, R., Kadler, K., Cook, J., Caterson, B., Dakin, S., Heinegard, D., Screen, H., Stover, S., Little, C., et al (2014). Advances in the understanding of tendinopathies: a report on the Second Havemeyer Workshop on equine tendon disease. Equine Veterinary Journal, 46(11), 4-9. [More Information]
Hodges, P., James, G., Blomster, L., Hall, L., Schmid, A., Shu, C., Little, C., Melrose, J. (2014). Can Proinflammatory Cytokine Gene Expression Explain Multifidus Muscle Fiber Changes After an Intervertebral Disc Lesion? Spine, 39(13), 1010-1017. [More Information]
Zaki, S., Miller, R., Malfait, A., Smith, S., Tran, P., Ishihara, S., Little, C. (2014). CHARACTERISATION OF PAIN-RELATED BEHAVIOURS IN ASSOCIATION WITH JOINT PATHOLOGY IN AN 8-WEEK ANTIGENINDUCED ARTHRITIS MODEL. Osteoarthritis and Cartilage, 22, 1-2.
Jackson, M., Moradi, B., Zaki, S., Smith, M., McCracken, S., Smith, S., Jackson, C., Little, C. (2014). Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms. Arthritis & Rheumatology, 66(12), 3337-3348. [More Information]
Xue, M., Shen, K., McKelvey, K., Li, J., Chan, Y., Hatzis, V., March, L., Little, C., Tonkin, M., Jackson, C. (2014). Endothelial protein C receptor associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2. Arthritis Research and Therapy, 16(1), 1-12. [More Information]
Miller, R., Zaki, S., Ishihara, S., Tran, P., Little, C., Malfait, A. (2014). ESTABLISHING A METHOD FOR MEASURING PRIMARY KNEE HYPERALGESIA IN THE MURINE DMM MODEL OF OSTEOARTHRITIS. Osteoarthritis and Cartilage, 22, 1-22.
El-Hoss, J., Kolind, M., Jackson, M., Deo, N., Mikulec, K., McDonald, M., Little, C., Little, D., Schindeler, A. (2014). Modulation of endochondral ossification by MEK inhibitors PD0325901 and AZD6244 (Selumetinib). Bone, 59, 151-161. [More Information]
Riordan, E., Little, C., Hunter, D. (2014). Pathogenesis of post-traumatic OA with a view to intervention. Best Practice & Research: Clinical Rheumatology, 28(1), 17-30. [More Information]
Chan, B., Zaki, S., Smith, S., Little, C., Purves, R. (2014). SHORT BUT NOT LONG TERM SCLEROSTIN INHIBITION WORSENS POST-TRAUMATIC OSTEOARTHRITIS IN MICE. Osteoarthritis and Cartilage, 22, 1-2.
Koenig, T., Dart, A., Mcllwraith, C., Horadagoda, N., Bell, R., Perkins, N., Dart, C., Krockenberger, M., Jeffcott, L., Little, C. (2014). Treatment of Experimentally Induced Osteoarthritis in Horses Using Intravenous Combination of sodium Pentosan Polysulfate, N-Acetyl Glucosamine, and Sodium Hyaluronan. Veterinary Surgery, 43(5), 612-622. [More Information]

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2013

Malfait, A., Little, C., Dougall, J. (2013). A commentary on modelling osteoarthritis pain in small animals. Osteoarthritis and Cartilage, 21(9), 1316-1326. [More Information]
Smith, M., Russell, A., Schiavinato, A., Little, C. (2013). A hexadecylamide derivative of hyaluronan (HYMOVIS(R)) has superior beneficial effects on human osteoarthritic chondrocytes and synoviocytes than unmodified hyaluronan. Journal of Inflammation, 10(1), 1-16. [More Information]
Melrose, J., Smith, M., Smith, S., Ravi, V., Young, A., Dart, A., Sonnabend, D., Little, C. (2013). Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy. Tissue and Cell, 45(1), 77-82. [More Information]
Shu, C., Smith, S., Little, C., Melrose, J. (2013). Comparative immunolocalisation of perlecan, heparan sulphate, fibroblast growth factor-18, and fibroblast growth factor receptor-3 and their prospective roles in chondrogenic and osteogenic development of the human foetal spine. European Spine Journal, 22(8), 1774-1784. [More Information]
Cake, M., Read, R., Corfield, G., Daniel, A., Burkhardt, D., Smith, M., Little, C. (2013). Comparison of gait and pathology outcomes of three meniscal procedures for induction of knee osteoarthritis in sheep. Osteoarthritis and Cartilage, 21(1), 226-236. [More Information]
Zaki, S., Smith, M., Smith, S., Connor, M., Little, C. (2013). Contrasting Pathophysiology and Behavioural Responses Associated With Osteoarthritis and An Inflammatory Arthropathy. Abstracts of Papers, , 1-3.
Smith, M., Ravi, V., Dart, A., Sonnabend, D., Little, C. (2013). Factors affecting tendinopathogenesis. British Journal of Sports Medicine, 47(9), 23-24. [More Information]
Smith, M., Dart, A., Little, C. (2013). Large proteoglycan metabolism in tendinopathy. British Journal of Sports Medicine, 47, 29-29.
Smith, M., Jacobson, E., Dart, A., Little, C. (2013). Large proteoglycan metabolism in tendinopathy. British Journal of Sports Medicine, 47(9), e2. [More Information]
Belluoccio, D., Rowley, L., Little, C., Bateman, J. (2013). Maintaining mRNA integrity during decalcification of mineralized tissues. PloS One, 8(3), 1-6. [More Information]
Little, C., Hunter, D. (2013). Post-traumatic osteoarthritis: from mouse models to clinical trials. Nature Reviews Rheumatology, 9(8), 485-497. [More Information]
Jackson, M., Moradi, B., Smith, S., Jackson, C., Little, C. (2013). Protease activated receptor-2 but not PAR-1, modulates synovial macrophage maturation in post-traumatic OA. Osteoarthritis and Cartilage, 21, S61.
Gossan, N., Zeef, L., Hensman, J., Hughes, A., Bateman, J., Rowley, L., Little, C., Piggins, H., Rattray, M., Boot-Handford, R., et al (2013). The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis. Arthritis & Rheumatology, 65(9), 2334-2345. [More Information]
Shu, C., Hughes, C., Smith, S., Smith, M., Hayes, A., Caterson, B., Little, C., Melrose, J. (2013). The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc. Glycoconjugate Journal, 30(7), 717-725. [More Information]
Bateman, J., Rowley, L., Belluoccio, D., Chan, B., Bell, K., Fosang, A., Little, C. (2013). Transcriptomics of Wild-Type Mice and Mice Lacking ADAMTS-5 Activity Identifies Genes Involved in Osteoarthritis Initiation and Cartilage Destruction. Arthritis & Rheumatology, 65(6), 1547-1560. [More Information]

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2012

Maher, A., Coles, C., White, J., Bateman, J., Fuller, E., Burkhardt, D., Little, C., Cake, M., Read, R., McDonagh, M., et al (2012). 1H NMR spectroscopy of serum reveals unique metabolic fingerprints associated with subtypes of surgically induced osteoarthritis in sheep. Journal of Proteome Research, 11(8), 4261-4268. [More Information]
Melrose, J., Isaacs, M., Smith, S., Hughes, C., Little, C., Caterson, B., Hayes, A. (2012). Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development. Histochemistry and Cell Biology, 138(3), 461-475. [More Information]
Zaki, S., Smith, M., Smith, S., Connor, M., Little, C., Purves, R. (2012). DISTINCT PAIN MECHANISMS IN TWO DIFFERENT MODELS OF ARTHRITIS. Osteoarthritis and Cartilage, 20, 1-2.
Melrose, J., Shu, C., Young, C., Ho, R., Smith, M., Young, A., Smith, S., Gooden, B., Dart, A., Podadera, J., Appleyard, R., Little, C. (2012). Mechanical destabilization induced by controlled annular incision of the intervertebral disc dysregulates metalloproteinase expression and induces disc degeneration. Spine, 37(1), 18-25. [More Information]
Boeuf, S., Graf, F., Fischer, J., Moradi, B., Little, C., Richter, W. (2012). Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells. European Cells and Materials, 23, 320-332. [More Information]
Chan, B., Little, C. (2012). The interaction of canonical bone morphogenetic protein- and Wnt-signaling pathways may play an important role in regulating cartilage degradation in osteoarthritis. Arthritis Research and Therapy, 14(3), 119-1-119-3. [More Information]
Little, C., Zaki, S. (2012). What constitutes an "animal model of osteoarthritis" - the need for consensus ? Osteoarthritis and Cartilage, 20(4), 261-267. [More Information]
Fuller, E., Smith, M., Little, C., Melrose, J. (2012). Zonal differences in meniscus matrix turnover and cytokine response. Osteoarthritis and Cartilage, 20(1), 49-59. [More Information]

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2011

Bernardo, B., Belluoccio, D., Rowley, L., Little, C., Hansen, U., Bateman, J. (2011). Cartilage Intermediate Layer Protein 2 (CILP-2) Is Expressed in Articular and Meniscal Cartilage and Down-regulated in Experimental Osteoarthritis. Journal of Biological Chemistry, 286(43), 37758-37767. [More Information]
Chan, B., Fuller, E., Russell, A., Smith, S., Smith, M., Jackson, M., Cake, M., Read, R., Bateman, J., Sambrook, P., Little, C. (2011). Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis and Cartilage, 19(7), 874-885. [More Information]
Stanton, H., Golub, S., Rogerson, F., Last, K., Little, C., Fosang, A. (2011). Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage. Nature Protocols, 6(3), 388-404. [More Information]
Lamande, S., Yuan, Y., Gresshoff, I., Rowley, L., Belluoccio, D., Kaluarachchi, K., Little, C., Botzenhart, E., Zerres, K., Amor, D., et al (2011). Mutations in TRPV4 cause an inherited arthropathy of hands and feet. Nature Genetics, 43(11), 1142-1146. [More Information]
Stanton, H., Melrose, J., Little, C., Fosang, A. (2011). Proteoglycan degradation by the ADAMTS family of proteinases. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1812 (12), 1616-1629. [More Information]
Glasson, S., Little, C. (2011). The recent paper "Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilization of the medial meniscus and increased joint laxity". Osteoarthritis and Cartilage, 19(8), 1076-1077. [More Information]

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2010

Schollum, M., Appleyard, R., Little, C., Melrose, J. (2010). A Detailed Microscopic Examination of Alterations in Normal Anular Structure Induced by Mechanical Destabilization in an Ovine Model of Disc Degeneration. Spine, 35(22), 1965-1973. [More Information]
Nguyen, T., Little, C., Yenson, V., Jackson, C., McCracken, S., Warning, J., Stevens, V., Gallery, E., Morris, J. (2010). Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance. Journal of Autoimmunity, 35(1), 86-97. [More Information]
Aigner, T., Cook, J., Gerwin, N., Glasson, S., Laverty, S., Little, C., McIlwraith, W., Kraus, V. (2010). Histopathology atlas of animal model systems - overview of guiding principles. Osteoarthritis and Cartilage, 18(SUPPL. 3), S2-S6. [More Information]
Melrose, J., Little, C. (2010). Immunolocalization of lymphatic vessels in human fetal knee joint tissues. Connective Tissue Research, 51(4), 289-305. [More Information]
Little, C., Fosang, A. (2010). Is cartilage matrix breakdown an appropriate therapeutic target in osteoarthritis - insights from studies of aggrecan and collagen proteolysis? Current Drug Targets, 11(5), 561-575. [More Information]
Fosang, A., Last, K., Stanton, H., Golub, S., Little, C., Brown, L., Jackson, D. (2010). Neoepitope antibodies against MMP-cleaved and aggrecanase-cleaved aggrecan. Methods in Molecular Biology (Clifton N.J.), 622, 312-47. [More Information]
Jackson, M., Smith, M., Smith, S., Jackson, C., Little, C. (2010). Protease activated receptor-2 and activated protein C in cartilage degradation. Osteoarthritis and Cartilage, 18(S2), S90-S90.
Zreiqat, H., Belluoccio, D., Smith, M., Wilson, R., Rowley, L., Jones, K., Ramaswamy, Y., Vogl, T., Roth, J., Bateman, J., Little, C. (2010). S100A8 and S100A9 in experimental osteoarthritis. Arthritis Research and Therapy, 12(1), 1-13. [More Information]
Little, C., Kim, Y. (2010). Targeting Cartilage Breakdown in Osteoarthritis. Journal of American Academy of Orthopaedic Surgeons, 18(4), 243-246.
Little, C., Smith, M., Cake, M., Read, R., Murphy, M., Barry, F. (2010). The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in sheep and goats. Osteoarthritis and Cartilage, 18(Suppl 3), S80-S92. [More Information]
Little, C. (2010). The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis and Cartilage, 18(3), S17-23. [More Information]

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2009

Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009). Activated protein C mediates a healing phenotype in cultured tenocytes. Journal of Cellular and Molecular Medicine, 13(4), 749-757. [More Information]
Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009). Activation of Cartilage Matrix Metalloproteinases by Activated Protein C. Arthritis & Rheumatology, 60(3), 780-791. [More Information]
Melrose, J., Burkhardt, D., Taylor, T., Dillon, C., Read, R., Cake, M., Little, C. (2009). Calcification in the ovine intervertebral disc: a model of hydroxyapatite deposition disease. European Spine Journal, 18(4), 479-489. [More Information]
Melrose, J., Gooden, B., Dart, A., Appleyard, R., Little, C. (2009). Dysregulation of metalloproteinase expression in a mechanical destabilization model of intervertebral disc degeneration in sheep. ACSR Spinal Research Symposium VII.
Dart, A., Little, C. (2009). Focal injury induces widespread pathology in equine superficial digital flexor tendons. 31st Bain Fallon Lectures, Australia.
Little, C., Barai, A., Burkhardt, D., Smith, S., Fosang, A., Werb, Z., Shah, M., Thompson, E. (2009). Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Care and Research, 60(12), 3723-3733. [More Information]
Smith, S., Whitelock, J., Iozzo, R., Little, C., Melrose, J. (2009). Topographical variation in the distributions of versican, aggrecan and perlecan in the foetal human spine reflects their diverse functional roles in spinal development. Histochemistry and Cell Biology, 132(5), 491-503. [More Information]

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2008

Little, C., Smith, M. (2008). Animal Models of Osteoarthritis. Current Rheumatology Reviews, 4(3), 175-182. [More Information]
Cake, M., Read, R., Edwards, S., Smith, M., Burkhardt, D., Little, C., Ghosh, P. (2008). Changes in gait after bilateral meniscectomy in sheep: effect of two hyaluronan preparations. Journal of Orthopaedic Science, 13(6), 514-523. [More Information]
Fosang, A., Little, C. (2008). Drug insight: aggrecanases as therapeutic targets for osteoarthritis. Nature clinical practice: Rheumatology, 4(8), 420-427. [More Information]
Fitzgerald, J., Rich, C., Burkhardt, B., Allen, J., Herzka, A., Little, C. (2008). Evidence for articular cartilage regeneration in MRL/MpJ mice. Osteoarthritis and Cartilage, 16(11), 1319-1326. [More Information]
Jacobson, E., Smith, M., Mondori, T., Smith, S., Dart, A., Little, C. (2008). Focal injury induces widespread pathology in equine superficial digital flexor tendons. Matrix Biology Society of Australia and New Zealand Annual Meeting MBSANZ 2008, Australia: Matrix Biology Society of Australia and New Zealand.
Melrose, J., Fuller, E., Roughley, P., Smith, M., Kerr, B., Hughes, C., Caterson, B., Little, C. (2008). Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues. Arthritis Research and Therapy, 10(4), 1-10. [More Information]
Gauci, S., Golub, S., Tutolo, L., Little, C., Sims, N., Lee, E., Mackie, E., Fosang, A. (2008). Modulating chondrocyte hypertrophy in growth plate and osteoarthritic cartilage. Journal of Musculoskeletal and Neuronal Interactions, 8(4), 308-310. [More Information]
Smith, M., Sakurai, G., Smith, S., Young, A., Melrose, J., Stewart, C., Appleyard, R., Peterson, J., Gilles, R., Dart, A., Sonnabend, D., Little, C. (2008). Modulation of Aggrecan and ADAMTS Expression in Ovine Tendinopathy Induced by Altered Strain. Seminars in Arthritis and Rheumatism, 58(4), 1055-1066. [More Information]
Melrose, J., Hayes, A., Whitelock, J., Little, C. (2008). Perlecan, the jack of all trades" proteoglycan of cartilaginous weight-bearing connective tissues.". BioEssays, 30(5), 457-469. [More Information]
Wilson, R., Belluoccio, D., Little, C., Fosang, A., Bateman, J. (2008). Proteomic characterization of mouse cartilage degradation in vitro. Seminars in Arthritis and Rheumatism, 58(10), 3120-3131. [More Information]
Melrose, J., Smith, S., Little, C., Moore, R., Vernon-Roberts, B., Fraser, R. (2008). Recent advances in annular pathobiology provide insights into rim-lesion mediated intervertebral disc degeneration and potential new approaches to annular repair strategies. European Spine Journal, 17(9), 1131-1148. [More Information]
Smith, M., Cake, M., Ghosh, P., Schiavinato, A., Read, R., Little, C. (2008). Significant synovial pathology in a meniscectomy model of osteoarthritis: modification by intra-articular hyaluronan therapy. Rheumatology (Print Edition), 47(8), 1172-1178. [More Information]
Smith, M., Smith, S., Kikukawa, K., Dart, A., Sonnabend, D., Little, C. (2008). Spacio-temporal changes in pathology and proteoglycan gene expression in shoulder tendons induced by overstress or stress deprivation. Matrix Biology Society of Australia and New Zealand Annual Meeting MBSANZ 2008, Australia: Matrix Biology Society of Australia and New Zealand.
Melrose, J., Smith, S., Fuller, E., Young, A., Roughley, P., Dart, A., Little, C. (2008). Spatial and temporal catabolism of the small leucine repeat proteoglycans (SLRPs) in an ovine annular lesion model of experimental intervertebral disc degeneration has structure-function implications. World Forum for Spine Research 2008, Switzerland: AO Foundation.
Smith, M., Smith, S., Kikukawa, K., Dart, A., Sonnabend, D., Little, C. (2008). Temporal change in proteoglycan gene expression and histopathology induced in sheep shoulder tendons by altered stress in vivo. Osteoarthritis Research Society International World Congress on Osteoarthritis OARSI 2008, United States: Osteoarthritis Research Society International.
Melrose, J., Smith, S., Smith, M., Little, C. (2008). The use of Histochoice (tmR) for histological examination of articular and growth plate cartilages, intervertebral disc and meniscus. Biotechnic and Histochemistry, 83(1), 47-53. [More Information]

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2007

Melrose, J., Smith, S., Appleyard, R., Little, C. (2007). Aggrecan, versican and type VI collagen are components of annular translamellar crossbridges in the intervertebral disc. European Spine Journal, Published online: 31 October 2007, 1-11. [More Information]
Alini, M., Eisenstein, S., Ito, K., Little, C., Kettler, A., Masuda, K., Melrose, J., Ralphs, J., Stokes, I., Wilke, H. (2007). Are animal models useful for studying human disc disorders/degeneration? European Spine Journal, Published online: 14 July 2007(0), 1-18. [More Information]
Melrose, J., Smith, S., Fuller, E., Young, A., Roughley, P., Dart, A., Little, C. (2007). Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discs. European Spine Journal, 16(12), 2193-2205. [More Information]
Little, C., Meeker, C., Golub, S., Lawlor, K., Farmer, P., Smith, S., Fosang, A. (2007). Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair. Journal of Clinical Investigation, 117(6), 1627-1636. [More Information]
Young, A., Appleyard, R., Smith, M., Melrose, J., Little, C. (2007). Dynamic Biomechanics Correlate With Histopathology in Human Tibial Cartilage: A Preliminary Study. Clinical Orthopaedics and Related Research, 462, 212-220. [More Information]
Smith, M., Little, C. (2007). Experimental Models of Osteoarthritis. In Moskowitz, Altman, Hochberg, Buckwalter & Glodberg (Eds.), Osteoarthritis: Diagnosis and Medical/ Surgical Management, (pp. 107-125). Philadelphia, USA: Lippincott Williams & Wilkins.
Powell, A., Little, C., Hughes, C. (2007). Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system. Arthritis & Rheumatology, 56(9), 3010-3019. [More Information]

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2006

Smith, M., Sakurai, A., Smith, S., Young, A., Melrose, J., Dart, A., Sonnabend, D., Little, C. (2006). Altered aggrecan and ADAMTS expression in overload-induced tendon pathology. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Young, A., McLennan, S., Smith, S., Smith, M., Melrose, J., Cake, M., Flannery, C., Sonnabend, D., Little, C. (2006). Changes in expression and immunolcalization of proteoglycan 4 / lubricin in cartilage in an ovine model of early osteoarthritis. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Little, C., Jackson, M., Smith, M., Burkhardt, D., Xue, M., Jackson, C. (2006). Potential role of activated protein C (APC) in articular cartilage degeneration. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Young, A., McLennan, S., Smith, M., Smith, S., Cake, M., Read, R., Melrose, J., Sonnabend, D., Flannery, C., Little, C. (2006). Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Research and Therapy, 8(2), 1-6. [More Information]

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2005

Stewart, M., Fosang, A., Little, C., Sandy, J. (2005). A murine epiphyseal chondrocyte model of ADAMTS 5-mediated aggrecanolysis. 2005 Annual Meeting Of The American Society for Bone and Mineral Research, United States: American Society for Bone and Mineral Research.
Little, C., Mittaz, L., Belluoccio, D., Rogerson, F., Campbell, I., Meeker, C., Bateman, J., Pritchard, M., Fosang, A. (2005). ADAMTS-1 knockout mice do not exhibit abnormalities in aggrecan turnover in vitro or in vivo. Arthritis & Rheumatology, 52(5), 1461-1472. [More Information]
Stanton, H., East, C., Golub, S., Rogerson, F., Lawlor, K., Little, C., Fosang, A. (2005). ADAMTS-5 is the major aggrecanase in cartilage: in vitro studies with ADAMTS-4 and ADAMTS-5 deficient mice. 51st Annual Meeting of Orthopaedic Research Society, USA: Orthopaedic Research Society.
Stanton, H., Rogerson, F., East, C., Golub, S., Lawlor, K., Meeker, C., Little, C., Last, K., Farmer, P., Campbell, I., et al (2005). ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro. Nature, 434(7033), 648-652. [More Information]
Fosang, A., Little, C., Meeker, C. (2005). Aggrecan knock-in mice are resistant to proteolysis by MMP or ADAMTS enzymes in the interglobular domain. Scandinavian Journal of Rheumatology, 34, 13-14.
Little, C., Flannery, C., Hughes, C., Goodship, A., Caterson, B. (2005). Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration. Osteoarthritis and Cartilage, 13(2), 162-170. [More Information]
Little, C., Meeker, C., Fosang, A. (2005). Generation of mice with aggrecan resistant to aggrecanase cleavage in the IGD. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Little, C., Meeker, C., Fosang, A. (2005). Generation of mice with aggrecan resistant to aggrecanase cleavage in the IGD. 51st Annual Meeting of the Orthopaedic Research Society, 30, 357.
Little, C., Meeker, C., Hembry, R., Sims, N., Lawlor, K., Golub, S., Last, K., Fosang, A. (2005). Matrix metalloproteinases are not essential for aggrecan turnover during normal skeletal growth and development. Molecular and Cellular Biology, 25(8), 3388-3399. [More Information]
Young, A., Smith, M., Smith, S., Burkhardt, D., Cake, M., Melrose, J., Read, R., Ghosh, P., Sonnabend, D., Little, C. (2005). Metabolism of Small Leucine-Rich Proteoglycans in an Ovine Model of Osteoarthritis. 51st Annual Meeting of the Orthopaedic Research Society, 30, 1057-1057.
Innes, J., Little, C., Hughes,, C., Caterson, B. (2005). Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early-and late-stage osteoarthritis. American Journal of Veterinary Research, 66(10), 1679-1685. [More Information]
Yang, Y., Hall, P., Little, C., Fosang, A., Milenkovski, G., Santos, L., Xue, J., Tipping, P., Morand, E. (2005). Reduction of Arthritis Severity in Protease-Activated Receptorâ€“Deficient Mice. Arthritis & Rheumatology, 52(4), 1325-1332. [More Information]
Young, A., Smith, M., Smith, S., Cake, M., Ghosh, P., Read, R., Melrose, J., Sonnabend, D., Roughley, P., Little, C. (2005). Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis. Arthritis Research and Therapy, 7(4), R852-61. [More Information]

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2004

Little, C., Mittaz, L., Meeker, C., Pritchard, M., Fosang, A. (2004). ADAMTS-1 knockout mice do not exhibit abnormalities in aggrecan turnover in-vivo or in-vitro. 50th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
Hughes, C., Caterson, B., Little, C., Wright, S. (2004). Aggrecanases 1 and 2. In Woessner F, Alan J. Barrett, Neil D. Rawlings (Eds.), Handbook of Proteolytic Enzymes, (pp. 740-740). Canada: Academic Press.
Janusz, M., Little, C., King, L., Hookfin, E., Brown, K., Heitmeyer, S., Caterson, B., Poole, A., Taiwo, Y. (2004). Detection of aggrecanase and MMP-generated catabolic neoepitopes in the rat iodacetate model of cartilage degeneration. Osteoarthritis and Cartilage, 12(9), 720-728. [More Information]
Little, C., Curtis, C., Cramp, J., Vaughn-Thomas, A., Harwood, J., Innes, J., Caterson, B. (2004). Differential effects of canine cartilage to cytokine stimulation and n-3 polyunsaturated fatty acids supplementation versus human and bovine cartilage. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.

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2003

Little, C., Cramp, J., Curtis, C., Richardson, D., Schoenherr, B., Innes, J., Jones, S., Caterson, B. (2003). Canine articular catilage degradation: The role of catabolic cytokines. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Jones, A., Hughes, C., Wainwright, S., Flannery, C., Little, C., Caterson, B. (2003). Degradation of PRG4/SZP by Matrix Proteases. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Little, C., Meeker, C., Fosang, A. (2003). Degradative mechanisms in mouse articular cartilage:use of in vitro models to analyse proteolysis and loss of aggrecan and link protein. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Rees, A., Hughes, C., Little, C., Caterson, B. (2003). Evidence for zymogen forms of aggrecanase-1 (ADAMTS-4) in chondrocyte-agarose cultures. 49th Annual Meeting of the Orthopaedic Research Society, United states: Orthopaedic Research Society.
Hughes, C., Little, C., Caterson, B. (2003). Measurement of aggrecanase-generated interglobular domain catabolites in the medium and extracts of cartilage explants using Western blot analysis. Methods in Molecular Biology, 225(-), 89-98.
Fosang, A., Stanton, H., Little, C., Atley, L. (2003). Neoepitopes as Biomarkers of Cartilage Catabolism. Inflammation Research, 52(7), 277-282. [More Information]
Dart, A., Little, C., Hughes, C., Chu, Q., Dowling, B., Hodgson, D., Rose, R., Johnson, K. (2003). Recombinant equine growth hormone administration: effects on synovial fluid biomarkers and cartilage metabolism in horses. Equine Veterinary Journal, 35(3), 302-307.

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2002

Little, C., Hughes, C., Curtis, C., Jones, S., Caterson, B., Flannery, C. (2002). Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage. Arthritis & Rheumatology, 46(1), 124-129.
Little, C., Flannery, C., Hughes, C., Precious, G., Otterness, I., Goodship, A., Caterson, B. (2002). Cytokine induced metalloproteinase expression and activity does not correlate with focal cartilage pathology. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
Little, C., Roughley, P., Otterness, I., Hughes, C., Caterson, B. (2002). Hiearchical catabolism of collagen associated proteoglycans in in vitro models of progressive articular cartilage degradation. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
Little, C., Hughes, C., Curtis, C., Janusz, M., Bohne, R., Wang-Weigand, S., Taiwo, Y., Mitchell, P., Otterness, I., Flannery, C., et al (2002). Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Matrix Biology, 21(3), 271-288. [More Information]
Curtis, C., Rees, S., Little, C., Flannery, C., Hughes, C., Dent, C., Wilson, C., Harwood, J., Caterson, B. (2002). N-3 fatty acid supplementation specifically ablates the activity and expression of aggrecanases and inflammatory mediators in human osteoarthritic cartilage. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
Curtis, C., Little, C., Rees, S., Flannery, C., Hughes, C., Otterness, I., Dent, C., Harwood, J., Caterson, B. (2002). N-3 fatty acids inhibit expression and activity of MMPs in human osteoarthritic cartilage. 48th Annual Meeting of the Orthopaedic Research Society, United States: Orthopaedic Research Society.
Little, C., Otterness, I., Hughes, C., Caterson, B. (2002). Proteolysis of type IX collagen and loss of biglycan, decorin and fibromodulin in progressive articual cartilage degradation. Oesteoarthritis and Cartilage.
Melrose, J., Smith, S., Little, C., Kitson, J., Hwa, S., Ghosh, P. (2002). Spatial and temporal localization of transforming growth factor-b, fibroblast growth factor-2, and osteonectin, and identification of cells expressing a-smooth muscle actin in the injured annulus fibrosus. Implications for extracellular matrix repair. Spine, 27(16), 1756-1764. [More Information]

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2001

Davies, J., Rees, A., Hughes, C., Little, C., Caterson, B. (2001). An immunohistochemical study of aggrecan catabolism in porcine articular cartilage. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
Diffin, F., Little, C., Elson, C., Westacott, C. (2001). Catabolism of aggrecan by cells derived from osteoarthritic bone. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
Flannery, C., Little, C., Hughes, C., Curtis, C., Caterson, B. (2001). Cyclosporin A inhibits IL-1-induced aggrecanase-mediated proteoglycan catabolism in situ in articular cartilage. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
Flannery, C., Little, C., Hughes, C., Curtis, C., Jones, S., Caterson, B. (2001). IL-6 and its soluable receptor augment aggrecanase-mediated proteoglycan catabolism in articular cartilage. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
Melrose, J., Smith, S., Little, C., Kitson,, J., Hwa, S., Ghosh, P. (2001). Repair of annular disc lesions: Spatial and temporal localisation of TGF-beta, SPARC (Osteonectin, BM-40) and FGF-2 are early responses in experimentally injured ovine discs. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
Little, C., Flannery, C., Hughes, C., Otterness, I., Caterson, B. (2001). Species specificity of neopitope antibodies to aggrecanase- and MMP- generated sequences in the interglobular domain of aggrecan. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.
Hwa, S., Burkhardt, D., Little, C., Ghosh, P. (2001). The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis. Journal of Rheumatology, 28(4), 825-834.
Little, C., Hughes, C., Otterness, I., Janusz, M., Caterson, B. (2001). The role of matrix metalloproteinases in c-terminal catabolism of aggrecan. 47th Annual Meeting of the Orthopaedic Research Society, USA: Orthopaedic Research Society.

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Selected Grants

2023

Getting to the Heart of Osteoarthritis (OA): targeting joint-derived micro-RNAs (miRs) to reduce OA-associated cardiovascular disease (CVD) risk, Little C, Shu C, Mihailidou A, Aston A, National Health and Medical Research Council (NHMRC)/Ideas Grant
Does mild joint injury and how its managed, increase risk of catastrophic injury and post-traumatic osteoarthritis?, Little C, Blaker C, Clarke E, Duong V, Cross T, Arthritis Foundation of Australia/Project Grants
Rewarding Research 2024, Little C, Faculty of Medicine and Health/FMH Rewarding Research Success

2022

Tissue engineering using iPSC-derived chondrocyte organoids to repair articular cartilage damage, Little C, Novo Nordisk Foundation/Research Grant

2021

Glycosaminoglycans in tendon disease - identifying new treatment targets, Blaker C, Little C, Clarke E, The Lincoln Centre/Research Grant
Ultracentrifuge, Little C, McCracken S, Figtree G, National Health and Medical Research Council (NHMRC)/Equipment Grant

2020

A novel regenerative therapy for treating osteoarthritis, Li J, Hosseini Beheshti E, Gentile C, Little C, Arthritis Foundation of Australia/Grants-in-Aid
A new regenerative therapy for treating thumb base osteoarthritis, Li J, Hosseini Beheshti E, Gentile C, Little C, Grau G, The Lincoln Centre/Research Grant

2019

Database of human tendon and ligament properties to assist the selection and development of idealgrafts for reconstruction, Little C, Clarke E, Blaker C, Australian Orthopaedic Association Research Foundation Ltd/Research Support
An optimised scaffold for osteochondral tissue regeneration designed through feedback system control, Li J, Ding X, Little C, Shen G, Xie H, Wang L, Office of Global Engagement/Partnership Collaboration Awards
Can stem cells improve flexor tendon repair after injury?, Little C, Tsang A, The Lincoln Centre/Research Grant
Kangaroo xenograft for tendon surgery in the hand, Clarke E, Little C, Blaker C, The Lincoln Centre/Research Grant

2018

A novel regenerative therapy for the treatment of osteoarthritis, Li J, Hosseini Beheshti E, Gentile C, Little C, Grau G, Lifespan Research Network/Lifespan Seed Grants Program
A novel regenerative therapy for treating osteoarthritis, Li J, Hosseini Beheshti E, Gentile C, Little C, Arthritis Foundation of Australia/Grants-in-Aid
The INTERLOCK Study, Little C, Umapathy H, Hunter D, Arthritis Foundation of Australia/Scholarship
CDIP Industry & Community Engagement Fund 2017_ Disease Modifying Therapies for Osteoarthritis _COCOON BIOTECH_LITTLE, Little C, DVC Research/Industry & Community Engagement Seed Fund (I&CEF)
Xenograft using Kangaroo Tendon as a substitute for ligament reconstruction in the human population - Innovative Manufacturing CRC Limited, Bone Ligament Tendon BLT and Allegra Orthopaedics, Little C, Clarke E, Zreiqat H, Innovative Manufacturing CRC (IMCRC)/CRC Research Project

2017

microRNAs as therapeutic targets for osteoarthritis, Little C, Bateman J, National Health and Medical Research Council (NHMRC)/Project Grants
A novel strategy for treating chronic joint injury, Li J, Little C, Zreiqat H, Arthritis Foundation of Australia/Grants-in-Aid
Xenograft using Kangaroo Tendon/Tail as a substitute for ligament reconstruction in the human population, Hartnell N, Sadeghpour A, Little C, Clarke E, Zreiqat H, Innovative Manufacturing CRC (IMCRC)/CRC Research Project
A new collaborative strategy for treating joint injury to prevent osteoarthritis, Li J, Zreiqat H, Little C, University of Sydney/SMS-FEIT Biomedical Engineering Research Collaboration Scheme
Vevo 3100 Preclinical Imaging Platform, Howell V, Little C, Figtree G, University of Sydney/Equipment Grant
Exploring the potential of a novel TRPV1 agonist (CA-008) for managing pain in a mouse model of post-traumatic osteoarthritis, Little C, Concentric Analgesics, Inc./Client Commissioned Research

2016

Laboratory Animal Behaviour Observation Registration and Analysis System - LABORAS, Little C, Sydney Medical School/Equipment Grant
Effect of Metformin on palmar fascia cells from patients with Dupuytren's contracture, Smith M, Little C, The Lincoln Centre/Research Support
Effects of localised compressive loading on tendon health, Clarke E, Little C, The Lincoln Centre/Research Support
Director of the Murray Maxwell Biomechanics Laboratory - Salary Support, Little C, Sydney Medical School Foundation/Academic Appointment

2015

DEFROST: Translating laboratory findings into a randomised placebo-controlled trial of metformin in frozen shoulder, Sonnabend D, Little C, Australian Orthopaedic Association Research Foundation Ltd/Research Support
Translational Osteoarthritis Pain Investigation Centre (TOPIC), Little C, Zaki S, Hillcrest Foundation/Perpetual IMPACT Philanthropy Program
Is mild joint injury an osteoarthritis risk?, Clarke E, Little C, Blaker C, Arthritis Foundation of Australia/Project Grants
ARC, a newly identified regulator of chondrocyte differentiation and death, is a novel therapeutic target for OA, Little C, Ashton A, Bateman J, National Health and Medical Research Council (NHMRC)/Project Grants
Effects of mechanical loads on tendon health and tendon type, Clarke E, Smith M, Little C, The Lincoln Centre/Research Support

2014

Investigating osteoarthritis following different injury mechanisms, Blaker C, Little C, Clarke E, Arthritis Foundation of Australia/Grants-in-Aid
The Role of Nol3 in Cartilage in Osteoarthritis , Little C, DVC Research/Bridging Support Grant
BD Fortessa Flow Cytometer, Morris J, Little C, Baxter R, Ward C, Ashton A, DVC Research/Equipment Grant

2013

Molecular mechanisms of joint degeneration in osteoarthritis, Bateman J, Little C, National Health and Medical Research Council (NHMRC)/Project Grants
Cell therapies for tendon disease, Little C, DVC Research/Bridging Support Grant
The diabetic hand - understanding the mechanisms of tendinopathy, Smith M, Little C, The Lincoln Centre/Research Support

2012

Serum microRNA biomarkers of osteoarthritis, Little C, Bateman J, Sonnabend D, Australian Orthopaedic Association Research Foundation Ltd/Research Grant
Synovial macrophages and T-cells are therapeutic targets in osteoarthritis, Little C, Hunter D, National Health and Medical Research Council (NHMRC)/Project Grants
Investigating the pain mechanisms in osteoarthritis, Zaki S, Little C, Connor M, Arthritis Foundation of Australia/Grants-in-Aid
Purves Visiting Professor - Professor Stefan Lohmander, Little C, Hunter D, Raymond E Purves Foundation/Research Grant

2011

Bruker Daltonics autoflex speed MALDI-TOF/TOF mass spectrometer, Baxter R, Halliday G, Marsh D, Gill A, Clarke S, Smith R, Little C, Jackson C, O'Neill C, Murphy C, Sharland A, Chadban S, Mason R, Assinder S, Verdurand M, Richardson D, Machaalani R, Hambly B, Chan-Ling T, Dos Remedios C, Holsinger D, Lay P, National Health and Medical Research Council (NHMRC)/Equipment Grant
Nano-mechanical and nano-structural investigation of dentine: unravelling a novel nano-scale regulator of high durability of mineralized tissues., Swain M, Little C, Australian Research Council (ARC)/Discovery Projects (DP)
The calcium channel TRPV4 in skeletal development and arthritis, Little C, McIntyre P, Lamande S, National Health and Medical Research Council (NHMRC)/Project Grants
Sclerostin Is A Key Regulator Of Wnt Signalling In Bone And Cartilage Pathology In Osteoarthritis, Little C, Sambrook P, National Health and Medical Research Council (NHMRC)/Project Grants

2010

Fluorescent microscopy of bone and joint tissues, Little C, Rebecca L Cooper Medical Research Foundation/Equipment Grant
Inflammation in post-traumatic osteoarthritis, Little C, Arthritis Foundation of Australia/Grants-in-Aid
Mesenchymal Progenitor cells and intervertebral disc repair, Melrose J, Appleyard R, Little C, National Health and Medical Research Council (NHMRC)/Project Grants
Studies of endogenous stem cells in tendon, Little C, Arthritis Foundation of Australia/Grants-in-Aid
Studies of endogenous stem cells in tendon, Little C, Perpetual Trustees Charitable Trusts/Research Support
Cellular mechanisms in chondroid degeneration of tendon, Little C, Sonnabend D, Smith M, Australian Orthopaedic Association Research Foundation Ltd/Research Support

2009

Research-Laboratory consumables, Little C, University of Liverpool/Research Support
MMI Smart Cut Plus laser microdissector, Baxter R, Little C, Marsh D, Keast J, National Health and Medical Research Council (NHMRC)/Equipment Grant
Bone-specific sclerostin and SIBLING proteins in osteoarthritis: novel contributions to cartilage and bone pathology, Little C, Sambrook P, National Health and Medical Research Council (NHMRC)/Project Grants

2008

Histology and immunohistology of large bone and joint tissue specimens, Little C, Rebecca L Cooper Medical Research Foundation/Equipment Grant
Biochemical Analysis of Samples for the Mesoblast Proj, Little C, Institute of Medical and Veterinary Science/Research Support
Stem Cell treatment for tendon degeneration, Little C, Smith M, Smith M, Sonnabend D, Appleyard R, Melrose J, Hunyor S, National Health and Medical Research Council (NHMRC)/Project Grants
Novel pathways involving APC and PAR-2 in cartilage degradation in osteoarthritis, Little C, Jackson C, National Health and Medical Research Council (NHMRC)/Project Grants

2007

An in-vitro model of meniscal degeneration initiated by inflammatory cytokines, Little C, Melrose J, Arthritis Foundation of Australia/Research Support FPRx1666 SCHx5059
Activated protein C and protease activated receptors (PARs) in cartilage degradation mechanisms in osteoarthritis, Little C, University of Sydney/Bridging Support
The role of perlacan in tensional connective tissues, Melrose J, Whitelock J, Hayes A, Whitelock J, Appleyard R, Little C, National Health and Medical Research Council (NHMRC)/Project Grants

2006

Metalloproteinase activation in cartilage remodeling, Little C, University of Sydney/Bridging Support

2005

Biomechanical testing to detect cartilage breakdown, Little C, Arthritis Foundation of Australia/Grants-In-Aid and Special Purpose Grants FPRx1666 SCHx4288
How important is collagen destruction in arthritis?, Fosang A, Little C, National Health and Medical Research Council (NHMRC)/Project Grants
Proteoglycan metabolism in tendon degeneration, Little C, Sonnabend D, Appleyard R, Melrose J, Fosang A, National Health and Medical Research Council (NHMRC)/Project Grants
Mechanisms of cartilage breakdown in osteoarthritis., Bateman J, Little C, Fosang A, National Health and Medical Research Council (NHMRC)/Project Grants
RotorGene 6000 real-time PCR, Little C, Clive & Vera Ramaciotti Foundation/Awards for Biomedical Research: Major Equipment
INSTRON 8874 Multi-axis Testing System, Little C, National Health and Medical Research Council (NHMRC)/Equipment Grant
Investigating the role of activated protein C (APC) in biochemical and biomechanical degeneration of cartilage in arthritis, Appleyard R, Little C, Royal North Shore Hospital/Area Research Grants
Evaluation of four genetically modified mice using a medial meniscal destabilization model of osteoarthritis (MMD induced OA), Little C, Pfizer Inc./Research Grants

2004

Investigation of the disease mechanisms in osteoarthritis, Little C, Rebecca L Cooper Medical Research Foundation/Research Grant
Inverted Fluorescence Microscopy: A sensitive method used to visualise protein expression in live cells, Davey R, Gallery E, Jackson C, Little C, Morris J, BLO DETYA National School Drug Education Strategy/RIGB Grant
Discovering which enzymes are important in joint disease., Fosang A, Little C, Stanton H, National Health and Medical Research Council (NHMRC)/Project Grants
Defining mechanisms of cartilage breakdown in arthritis, Little C, Arthritis Research Taskforce/Ulysses Arthritis Research Taskforce Fellowship
Pathobiology of the small leucine rich repeat proteoglycans in cartilage, intervertebral disc and tendon degeneration, Melrose J, Little C, Sonnabend D, National Health and Medical Research Council (NHMRC)/Project Grants
Testing CSIRO compounds PDS-1 and DS in collagen-induced arthritis in mice, Haaima G, Little C, Commonwealth Scientific and Industrial Research Organisation/Livestock Industries
The role of aggrecan turnover in tendon pathology., Appleyard R, Little C, Smith M, Sonnabend D, Australian Orthopaedic Association Research Foundation Ltd/Research Grant
Evaluation and validation of medical Destabilization in mice as a model of Osteoarthritis., Lanfear J, Little C, Pfizer Inc./Pfizer Pty Ltd

2003

Laboratory studies on articular cartilage and synovium to evaluate the effects of intra-articular treatments of hyaluronan (Hyalgan-E, Hyalgan-F and /or HYADD4) in an ovine model of osteoarthritis., Little C, Melrose J, Smith M, FIDIA Pharmaceuticals/Research Grant
Biomechanical and biochemical mechanisms of tendon homeostasis in normal, pathological and post-operative states., Appleyard R, Dart A, Little C, Smith M, Sonnabend D, Australian Orthopaedic Association Research Foundation Ltd/Research Grant
The role of cathepsin K in musculoskeletal disorders: potential modulation by pentosan polysulphate., Little C, Melrose J, Smith M, Sylvan Pharmaceuticals Pty Ltd/Research Grant

2002

Development of antibodies to investigate the mechanisms of aggrecan catabolism in development, growth and disease, Little C, University of Melbourne/Early Career Researcher Development Award

2001

The role of aggrecanase and MMPs in the initiation and progression of arthritis using proteinase resistant knock-in mice, Little C, Arthritis Research Taskforce/Ulysses Arthritis Research Taskforce Fellowship

2000

Mechanisms of matrix proteoglycan catabolism in articular cartilage, Caterson B, Hughes C, Little C, Arthritis Research Taskforce/Arthritis Research Campaign (UK)

1998

Diagnosis and monitoring of joint pathology in the horse, Caterson B, Little C, Horse Trust (UK)/Home of Rest for Horses
Catabolism of the collagen-associated leucine-rich repeat proteoglycans in articular cartilage degeneration, Caterson B, Little C, Arthritis Research Taskforce/Arthritis Research Campaign (UK)

Faculty of Medicine and Health

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Professor Christopher Little

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