People_
Dr Chuanmin Wang
Research Fellow
Surgery, Central Clinical School
Surgery, Central Clinical School
Details
Member of the Charles Perkins Centre
Dr. Chuanmin Wang has been working in the Department of Transplantation Surgery, University of Sydney since 1995. His main research is focusing in the area of transplantation immunology using small animal models to explore the mechanism of transplant tolerance and rejection.
He is not only a transplantation immunologist, but also an expert in Microsurgery. Except his excellent research work, he is involved in teaching and supervising young surgeons in their microsurgery training programe in the Microsearch Laboratories, University of Sydney.
Obesity, Diabetes and Cardiovascular Disease, Infection and Immunological Conditions, Healthy Ageing
Publications
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Book Chapters
- Behre, H., Wang, C., Handelsman, D., Nieschlag,, E. (2004). Pharmacology of Testosterone Preparation. In Nieschlag E, Behre HM (Eds.), Testosterone: Action, Deficiency and Substitution, (pp. 405-444). United Kingdom: Cambridge University Press.
Journals
- Lau, N., Ly, M., Dennis, C., Ewenson, K., Ly, H., Huang, J., Cabanes Creus, M., Chanda, S., Wang, C., Lisowski, L., Liu, K., Kench, J., McCaughan, G., Pulitano, C., et al (2023). Liver splitting during normothermic machine perfusion: a novel method to combine the advantages of both in-situ and ex-vivo techniques. HPB, 25(5), 543-555. [More Information]
- Lau, N., Ly, M., Dennis, C., Jacques, A., Cabanes Creus, M., Toomath, S., Huang, J., Mestrovic, N., Yousif, P., Chanda, S., Wang, C., Lisowski, L., Liu, K., Kench, J., McCaughan, G., Crawford, M., Pulitano, C. (2023). Long-term ex situ normothermic perfusion of human split livers for more than 1 week. Nature Communications, 14(1). [More Information]
- Son, E., Paul-Heng, M., Leong, M., Wang, C., Hill, A., Denkova, M., Purcell, A., Mifsud, N., Sharland, A. (2023). Screening self-peptides for recognition by mouse alloreactive CD8+ T cells using direct ex vivo multimer staining. STAR Protocols, 4(1). [More Information]
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2023
- Lau, N., Ly, M., Dennis, C., Ewenson, K., Ly, H., Huang, J., Cabanes Creus, M., Chanda, S., Wang, C., Lisowski, L., Liu, K., Kench, J., McCaughan, G., Pulitano, C., et al (2023). Liver splitting during normothermic machine perfusion: a novel method to combine the advantages of both in-situ and ex-vivo techniques. HPB, 25(5), 543-555. [More Information]
- Lau, N., Ly, M., Dennis, C., Jacques, A., Cabanes Creus, M., Toomath, S., Huang, J., Mestrovic, N., Yousif, P., Chanda, S., Wang, C., Lisowski, L., Liu, K., Kench, J., McCaughan, G., Crawford, M., Pulitano, C. (2023). Long-term ex situ normothermic perfusion of human split livers for more than 1 week. Nature Communications, 14(1). [More Information]
- Son, E., Paul-Heng, M., Leong, M., Wang, C., Hill, A., Denkova, M., Purcell, A., Mifsud, N., Sharland, A. (2023). Screening self-peptides for recognition by mouse alloreactive CD8+ T cells using direct ex vivo multimer staining. STAR Protocols, 4(1). [More Information]
2022
- Lai, C., Chadban, S., Loh, Y., Kwan, T., Wang, C., Singer, J., Niewold, P., Ling, Z., Spiteri, A., Getts, D., King, N., Wu, H. (2022). Targeting inflammatory monocytes by immune-modifying nanoparticles prevents acute kidney allograft rejection. Kidney International, 102(5), 1090-1102. [More Information]
2021
- Hall, B., Hall, R., Tran, G., Robinson, C., Wilcox, P., Rakesh, P., Wang, C., Sharland, A., Verma, N., Hodgkinson, S. (2021). Interleukin-5 (IL-5) Therapy Prevents Allograft Rejection by Promoting CD4+CD25+ Ts2 Regulatory Cells That Are Antigen-Specific and Express IL-5 Receptor. Frontiers in Immunology, 12, 714838. [More Information]
2020
- Wu, H., Singer, J., Kwan, T., Loh, Y., Wang, C., Tan, J., Li, Y., Lai, S., Macia, L., Alexander, S., Chadban, S. (2020). Gut microbial metabolites induce donor-specific tolerance of kidney allografts through induction of T regulatory cells by short-chain fatty acids. Journal of the American Society of Nephrology, 31(7), 1445-1461. [More Information]
2019
- Verma, N., Robinson, C., Carter, N., Wilcox, P., Tran, G., Wang, C., Sharland, A., Nomura, M., Plain, K., Bishop, G., Hodgkinson, S., et al (2019). Alloactivation of Naive CD4(+)CD8(-) CD25(+)T Regulatory Cells: Expression of CD8 alpha Identifies Potent Suppressor Cells That Can Promote Transplant Tolerance Induction. Frontiers in Immunology, 10(OCT), 1-15. [More Information]
2018
- Paul-Heng, M., Leong, M., Cunningham, E., Bunker, D., Bremner, K., Wang, Z., Wang, C., Tay, S., McGuffog, C., Logan, G., Alexander, I., Hu, M., Alexander, S., Bertolino, P., Bowen, D., Bishop, A., Sharland, A., et al (2018). Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction. JCI Insight, 3(15), 1-19. [More Information]
2016
- Wang, C., Beadnall, H., Hatton, S., Bader, G., Tomic, D., Silva, D., Barnett, M. (2016). Automated brain volumetrics in multiple sclerosis: a step closer to clinical application. Journal of Neurology, Neurosurgery and Psychiatry, 87(7), 754-757. [More Information]
2014
- Wang, C., Wang, Z., Allen, R., Bishop, A., Sharland, A. (2014). A Modified Method for Heterotopic Mouse Heart Transplantion. Journal of Visualized Experiments, 88, 1-5. [More Information]
- Verma, N., Hall, B., Plain, K., Robinson, C., Boyd, R., Tran, G., Wang, C., Bishop, A., Hodgkinson, S. (2014). Interleukin-12 (IL-12p70) Promotes Induction of Highly Potent Th1-Like CD4⁺CD25⁺ T Regulatory Cells That Inhibit Allograft Rejection in Unmodified Recipients. Frontiers in Immunology, 5, 1-11. [More Information]
- Wang, Z., Wang, C., Cunningham, E., Allen, R., Sharland, A., Bishop, A. (2014). Optimized method for ureteric reconstruction in a mouse kidney transplant model. ANZ Journal of Surgery, 84(6), 481-485. [More Information]
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2013
- Ilie, V., Ilie, V., Wang, C., Bishop, A. (2013). A simpler rat kidney transplantation model: a variation in arterial anastomotic technique. European Journal of Plastic Surgery, 36(6), 341-344. [More Information]
- Cunningham, E., Tay, S., Wang, C., Rtshiladze, M., Wang, Z., McGuffog, C., Cubitt, J., McCaughan, G., Alexander, I., Bertolino, P., Sharland, A., Bowen, D., Bishop, A. (2013). Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts. Transplantation, 95(1), 70-77. [More Information]
- Hu, M., Wang, C., Zhang, G., Saito, M., Wang, Y., Fernandez, M., Wang, Y., Wu, H., Hawthorne, W., Jones, C., O'Connell, P., Bishop, A., Sharland, A., Alexander, S., et al (2013). Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American Journal of Transplantation, 13, 2819-2830. [More Information]
2012
- Ganbold, A., Andersen, S., Tay, S., Cunningham, E., Ilie, V., Krishnan, S., Wang, C., McCaughan, G., Sharland, A., Bishop, A. (2012). Expression of common gamma chain signalling cytokines and their receptors distinguishes rejection from tolerance in a rat organ transplant model. Transplant Immunology, 27(2-3), 89-94. [More Information]
- Cubitt, J., Pennington, T., Wang, C., Allen, R., Bishop, A., Sharland, A. (2012). Reliable and reproducible murine models for commonly used abdominal plastic surgical flaps. Journal of Reconstructive Microsurgery, 28(3), 161-166. [More Information]
2011
- van Leest, Y., Moroso, V., Wang, C., Tay, S., Cunningham, E., Ilie, V., Bishop, A., Kwekkeboom, J. (2011). No evidence for involvement of donor NK cells in liver transplant tolerance. Transplant Immunology, 24(2), 138-139. [More Information]
- Wang, C., Cordoba, S., Hu, M., Bertolino, P., Bowen, D., Sharland, A., Allen, R., Alexander, S., McCaughan, G., Bishop, A. (2011). Spontaneous acceptance of mouse kidney allografts is associated with increased Foxp3 expression and differences in the B and T cell compartments. Transplant Immunology, 24(3), 149-156. [More Information]
2010
- Wang, C., Tay, S., Tran, G., Hodgkinson, S., Allen, R., Hall, B., McCaughan, G., Sharland, A., Bishop, A. (2010). Donor IL-4 treatment induces alternatively activated liver macrophages and IDO-Expressing NK cells and promotes rat liver allograft acceptance. Transplant Immunology, 22(3-4), 172-178. [More Information]
2009
- Laurence, J., Wang, C., Zheng, M., Cunningham, S., Earl, J., Tay, S., Allen, R., McCaughan, G., Alexander, I., Bishop, A., Sharland, A. (2009). Overexpression of indoleamine dioxygenase in rat liver allografts using a high-efficiency adeno-associated virus vector does not prevent acute rejection. Liver Transplantation, 15(2), 233-241. [More Information]
2008
- Laurence, J., Wang, C., Park, E., Buchanan, A., Clouston, A., Allen, R., McCaughan, G., Bishop, A., Sharland, A. (2008). Blocking indoleamine dioxygenase activity early after rat liver transplantation prevents long-term survival but does not cause acute rejection. Transplantation, 85(9), 1357-1361. [More Information]
- Lam, V., Taylor, C., Laurence, J., Wang, C., Sharland, A., McCaughan, G., Hodgkinson, S., Allen, R., Hall, B., Bishop, A. (2008). Heart allograft acceptance induced by anti-CD3 antibody in high-responder rats: Effect on foxp3 and cytokine expression and graft infiltration. Transplant Immunology, 19(1), 20-24. [More Information]
2006
- Liu, T., Dilworth, P., Sosef, M., Wang, C., Crawford, M., Gallagher, J., Verran, D. (2006). Arterial vascular conduits in adult orthotopic liver transplant recipients. ANZ Journal of Surgery, 76, 64-67. [More Information]
- Wang, C., Cordoba, S., Bertolino, P., Alexander, S., Wu, M., Allen, R., McCaughan, G., Bishop, A. (2006). Examination of the immune mechanism of spontaneous tolerance of renal allografts in a mouse model. Immunology and Cell Biology, 84(1), A29-30.
- Cordoba, S., Wang, C., Williams, R., Li, J., Smit, L., Sharland, A., Allen, R., McCaughan, G., Bishop, A. (2006). Gene array analysis of a rat model of liver transplant tolerance identifies increased complement C3 and the STAT-1/IRF-1 pathway during tolerance induction. Liver Transplantation, 12(4), 636-643. [More Information]
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2005
- Cordoba, S., Wang, C., Li, J., Bertolino, P., McCaughan, G., Bishop, A. (2005). Examination of immune mechanisms in a mouse model of spontaneous renal allograft acceptance. Immunology and Cell Biology, 83(4 Supplement), A20-A21.
- Hu, M., Wang, C., Cordoba, S., Zhang, G., Wang, Y., Watson, D., Bishop, A., Alexander, S. (2005). Foxp3 expression correlates with tolerance in a mouse allograft model of cardiac rejection and renal tolerance. Immunology and Cell Biology, 83(4), A21-A21.
- Cordoba, S., Wang, C., Williams, R., Sharland, A., McCaughan, G., Bishop, A. (2005). Meta-analysis of transcriptional profiles in three models of transplant tolerance identifies the STAT-1/IRF-1 pathway. Immunology and Cell Biology, 83(4), A31-A31.
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2004
- Den Dulk, M., Wang, C., Li, J., Clark, D., Hibberd, A., Terpstra, O., McCaughan, G., Bishop, A. (2004). Combined Donor Leucocyte Administration And Immunosuppressive Drug Treatment For Survival Of Rat Heart Allografts. Transplant Immunology, 13(3), 177-184. [More Information]
- Behre, H., Wang, C., Handelsman, D., Nieschlag,, E. (2004). Pharmacology of Testosterone Preparation. In Nieschlag E, Behre HM (Eds.), Testosterone: Action, Deficiency and Substitution, (pp. 405-444). United Kingdom: Cambridge University Press.
2002
- Bishop, A., Wang, C., Sharland, A., McCaughan, G. (2002). Spontaneous acceptance of liver transplants in rodents: evidence that liver leucocytes induce recipient T-cell death by neglect. Immunology and Cell Biology, 80(1), 93-100. [More Information]
2001
- Wang, C., Sun, J., Sheil, A., McCaughan, G., Bishop, A. (2001). A short course of methylprednisolone immunosuppression inhibits both rejection and spontaneous acceptance of rat liver allografts. Transplantation, 72(1), 44-51. [More Information]
- Wang, C., Sun, J., Horvat, M., Koutalistras, N., Sheil, A. (2001). Donor Cell Migration and Graft-Infiltrating Cell Apoptosis in Heart Acceptance in a Multiorgan Transplant Model. Transplantation Proceedings, 33(1-2), 135-135. [More Information]
- Wang, X., Sun, J., Wang, C., France, M., Sheil, A. (2001). Effect of liver transplantation on islet allografts: up-regulation of Fas ligand and apoptosis of T lymphocytes are associated with islet graft tolerance. Transplantation, 72(1), 102-111. [More Information]
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2000
- Sheil, A., Sun, J., Wang, L., Rao, A., Mears, D., Wang, C., Woodman, K., Johnstone, B., Watson, J. (2000). A Biodialysis system for liver support tested in a porcine hepatic failure model. ANZ Journal of Surgery, 70(2), 127-131.
- Wang, L., Sun, J., Wang, C., Woodman, K., Li, L., Wu, L., Harbour, C., Johnstone, B., Shi, L., Horvat, G., Koutalistras, N., Watson, J., Sheil, A., et al (2000). Analysis of Multivariables during Porcine Liver Digestion to Improve Hepatocyte yield and viability for use in Bioartificial Liver. Cell Transplantation, 9, 329-336.
- Wu, L., Sun, J., Wang, C., Qin, G., Koutalistras, N., Sheil, A. (2000). Donor Cell Chimerism, Host Lymphocyte Phenotype and Allograft Acceptance. Transplantation Proceedings, 32(7), 2043-2044. [More Information]
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Selected Grants
2003
- Basic mechanism of spontaneous tolerance of liver allografts in a rat model, Bishop A, McCaughan G, Rasko J, Sharland A, Wang C, National Health and Medical Research Council (NHMRC)/Project Grants