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Associate Professor David Bowen
Associate Professor of Medicine, Central Clinical School and Centenary Institute
Phone
+61 2 9565 6264
Infection and Immunological Conditions, Healthy Ageing, Lifespan
Publications
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Book Chapters
- Bowen, D., Bertolino, P. (2014). Immune Responses to the Hepatitis C Virus. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 476-486). New York: Springer Science+Business Media. [More Information]
- Bertolino, P., Bowen, D. (2014). Primary T-Cell Activation in Liver. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 899-905). New York: Springer Science+Business Media. [More Information]
- Bowen, D. (2012). Immune Responses to HCV: Implications for Therapy. In Geoffrey W. McCaughan, John G. McHutchison, Jean-Michel Pawlotsky (Eds.), Advanced Therapy for Hepatitis C, (pp. 17-24). Chichester, United Kingdom: Wiley-Blackwell Publishing. [More Information]
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Journals
- Tang, L., Chetwood, J., Lai, M., Yip, T., Cao, R., Powter, E., Salimi, S., Wu, R., Coulshed, A., Bowen, D., Strasser, S., Crawford, M., Pulitano, C., McKenzie, C., Kench, J., McCaughan, G., Liu, K., et al (2024). Incidence, epidemiology and outcomes of acute allograft rejection following liver transplantation in Australia. Liver Transplantation, 30(10), 1039-1049. [More Information]
- Tang, L., Bowen, D., Strasser, S., Valliani, T., Crawford, M., Pulitano, C., McKenzie, C., Kench, J., McCaughan, G., Liu, K., Chetwood, J., et al (2024). Incidence, epidemiology, and outcomes of acute allograft rejection following liver transplantation in Australia. Liver Transplantation, 30(10), 1039-1049. [More Information]
- Chetwood, J., Sabih, A., Chan, K., Salimi, S., Sheiban, A., Lin, E., Chin, S., Gu, B., Sastry, V., Coulshed, A., Tsoutsman, T., Bowen, D., Majumdar, A., Strasser, S., McCaughan, G., Liu, K. (2023). Epidemiology, characteristics, and outcomes of patients with acute-on-chronic liver failure in Australia. Journal of Gastroenterology and Hepatology, 38(8), 1352-1332. [More Information]
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2024
- Tang, L., Chetwood, J., Lai, M., Yip, T., Cao, R., Powter, E., Salimi, S., Wu, R., Coulshed, A., Bowen, D., Strasser, S., Crawford, M., Pulitano, C., McKenzie, C., Kench, J., McCaughan, G., Liu, K., et al (2024). Incidence, epidemiology and outcomes of acute allograft rejection following liver transplantation in Australia. Liver Transplantation, 30(10), 1039-1049. [More Information]
- Tang, L., Bowen, D., Strasser, S., Valliani, T., Crawford, M., Pulitano, C., McKenzie, C., Kench, J., McCaughan, G., Liu, K., Chetwood, J., et al (2024). Incidence, epidemiology, and outcomes of acute allograft rejection following liver transplantation in Australia. Liver Transplantation, 30(10), 1039-1049. [More Information]
2023
- Chetwood, J., Sabih, A., Chan, K., Salimi, S., Sheiban, A., Lin, E., Chin, S., Gu, B., Sastry, V., Coulshed, A., Tsoutsman, T., Bowen, D., Majumdar, A., Strasser, S., McCaughan, G., Liu, K. (2023). Epidemiology, characteristics, and outcomes of patients with acute-on-chronic liver failure in Australia. Journal of Gastroenterology and Hepatology, 38(8), 1352-1332. [More Information]
- Allen, N., Martin, A., Snaidr, V., Eggins, R., Chong, A., Fernandez Penas, P., Gin, D., Sidhu, S., Paddon, V., Banney, L., Lim, A., McKenzie, C., Scolyer, R., Dhillon, H., Vardy, J., Chadban, S., Bowen, D., Chen, A., Damian, D., et al (2023). Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients. New England Journal of Medicine, 388(9), 804-812. [More Information]
- Kaur, R., Hakim, J., Jeremy, R., Coorey, G., Kalman, E., Jenkin, R., Bowen, D., Hart, J. (2023). Students' perceived research skills development and satisfaction after completion of a mandatory research project: results from five cohorts of the Sydney medical program. BMC Medical Education, 23(1), 502. [More Information]
2022
- Dennis, C., Prince, D., Moayed-Alaei, L., Remash, D., Carr-Boyd, E., Bowen, D., Strasser, S., Crawford, M., Pulitano, C., Kench, J., McCaughan, G., McKenzie, C., Liu, K. (2022). Association between vessels that encapsulate tumour clusters vascular pattern and hepatocellular carcinoma recurrence following liver transplantation. Frontiers in Oncology, 12. [More Information]
- Chen, J., Zhao, Y., Zhang, F., Li, J., Boland, J., Cheng, N., Liu, K., Tiffen, J., Bertolino, P., Bowen, D., Lisowski, L., Alexander, I., Vadas, M., Gamble, J., McCaughan, G., et al (2022). Liver-specific deletion of miR-181ab1 reduces liver tumour progression via upregulation of CBX7. Cellular and Molecular Life Sciences, 79(8). [More Information]
- Hart, J., Hakim, J., Kaur, R., Jeremy, R., Coorey, G., Kalman, E., Jenkin, R., Bowen, D. (2022). Research supervisors' views of barriers and enablers for research projects undertaken by medical students; a mixed methods evaluation of a post-graduate medical degree research project program. BMC Medical Education, 22(1), 370. [More Information]
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2021
- McCarthy, R., Bowen, D., Strasser, S., McKenzie, C. (2021). The dangers of herbal weight loss supplements: a case report of drug-induced liver injury secondary to Garcinia cambogia ingestion. Pathology, 53(4), 545-547. [More Information]
- Son, E., Faridi, P., Paul-Heng, M., Leong, M., English, K., Ramarathinam, S., Braun, A., Dudek, N., Alexander, I., Lisowski, L., Bowen, D., Sharland, A., et al (2021). The self-peptide repertoire plays a critical role in transplant tolerance induction. Journal of Clinical Investigation, 131(21), e146771. [More Information]
- English, K., Bowen, D., Bertolino, P. (2021). Zone defence – the gut microbiota position macrophages for optimal liver protection. Immunology and Cell Biology, 99(6), 565-5.69E+02. [More Information]
2020
- Valencia-Hernandez, A., Ng, W., Ghazanfari, N., Ghilas, S., de Menezes, M., Holz, L., Huang, C., English, K., Naung, M., Tan, P., Bowen, D., Bertolino, P., et al (2020). A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice. Cell Host and Microbe, 27(6), 950-962.e7. [More Information]
- Holz, L., Chua, Y., de Menezes, M., Anderson, R., Draper, S., Compton, B., Chan, S., Mathew, J., Li, J., Kedzierski, L., Bertolino, P., Bowen, D., et al (2020). Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria. Science Immunology, 5(48), eaaz8035. [More Information]
- McCaughan, G., Bowen, D., Bertolino, P. (2020). Induction Phase of Spontaneous Liver Transplant Tolerance. Frontiers in Immunology, 11, 1908. [More Information]
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2019
- Yee, C., Main, N., Terry, A., Stevanovski, I., Maczurek, A., Morgan, A., Calabro, S., Potter, A., Iemma, T., Bowen, D., Warner, F., McCaughan, G., McLennan, S., Shackel, N., et al (2019). CD147 mediates intrahepatic leukocyte aggregation and determines the extent of liver injury. PloS One, 14(7), 1-19. [More Information]
- Mekonnen, Z., Grubor-Bauk, B., English, K., Leung, P., Masavuli, M., Shrestha, A., Bertolino, P., Bowen, D., Lloyd, A., Gowans, E., et al (2019). Single-Dose Vaccination with a Hepatotropic Adeno-associated Virus Efficiently Localizes T Cell Immunity in the Liver with the Potential To Confer Rapid Protection against Hepatitis C Virus. Journal of Virology, 93(19), 1-19. [More Information]
- Vidot, H., Cvejic, E., Finegan, L., Shores, E., Bowen, D., Strasser, S., McCaughan, G., Carey, S., Allman-Farinelli, M., Shackel, N. (2019). Supplementation with synbiotics and/or branched chain amino acids in hepatic encephalopathy: A pilot randomised placebo-controlled clinical study. Nutrients, 11(8), 1-17. [More Information]
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2018
- Paul-Heng, M., Leong, M., Cunningham, E., Bunker, D., Bremner, K., Wang, Z., Wang, C., Tay, S., McGuffog, C., Logan, G., Alexander, I., Hu, M., Alexander, S., Bertolino, P., Bowen, D., Bishop, A., Sharland, A., et al (2018). Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction. JCI Insight, 3(15), 1-19. [More Information]
- Pulitano, C., Ho, P., Verran, D., Sandroussi, C., Joseph, D., Bowen, D., McCaughan, G., Crawford, M., Shackel, N. (2018). Molecular Profiling of Post-Reperfusion Milieu Determines Acute Kidney Injury after Liver Transplantation: A Prospective Study. Liver Transplantation, 24(7), 922-931. [More Information]
- Reid, S., Day, C., Bowen, D., Minnis, J., Ludlow, J., Jacobs, S., Gordon, A., Haber, P. (2018). Vertical transmission of hepatitis C: Testing and health-care engagement. Journal of Paediatrics and Child Health, 54(6), 647-652. [More Information]
2017
- Sierro, F., Evrard, M., Rizzetto, S., Melino, M., Mitchell, A., Florido, M., Beattie, L., Walters, S., Tay, S., Lu, B., Roediger, B., Wong, Y., Warren, A., Ritchie, W., McGuffog, C., Weninger, W., Le Couteur, D., Britton, W., Saunders, B., McCaughan, G., Bowen, D., Bertolino, P., et al (2017). A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment. Immunity, 47(2), 374-388. [More Information]
- Vidot, H., Bowen, D., Carey, S., McCaughan, G., Allman-Farinelli, M., Shackel, N. (2017). Aggressive nutrition intervention reduces ascites and frequency of paracentesis in malnourished patients with cirrhosis and ascites. JGH Open, 1(3), 92-97. [More Information]
- De Willige, S., Keane, F., Bowen, D., Malfliet, J., Zhang, H., Maneck, B., McCaughan, G., Leebeek, F., Rijken, D., Gorrell, M. (2017). Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease. PloS One, 12(6), 1-8. [More Information]
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2016
- McCaughan, G., Crawford, M., Sandroussi, C., Koorey, D., Bowen, D., Shackel, N., Strasser, S. (2016). Assessment of adult patients with chronic liver failure for liver transplantation in 2015: who and when? Internal Medicine Journal, 46(4), 404-412. [More Information]
- Vo, M., Holz, L., Wong, Y., English, K., Benseler, V., McGuffog, C., Azuma, M., McCaughan, G., Bowen, D., Bertolino, P. (2016). Effector T cell function rather than survival determines extent and duration of hepatitis in mice. Journal of Hepatology, 64(6), 1327-1338. [More Information]
- Sivam, S., Al-Hindawi, Y., Di Michiel, J., Moriarty, C., Spratt, P., Jansz, P., Malouf, M., Plit, M., Pleass, H., Havryk, A., Bowen, D., Haber, P., Bye, P., et al (2016). Liver and lung transplantation in cystic fibrosis: an adult cystic fibrosis centre's experience. Internal Medicine Journal, 46(7), 852-854. [More Information]
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2015
- Rahman, W., Tu, T., Budzinska, M., Huang, P., Belov, L., Chrisp, J., Christopherson, R., Warner, F., Bowden, D., Thomspon, A., Bowen, D., Strasser, S., Sharland, A., Yang, J., McCaughan, G., Shackel, N., et al (2015). Analysis of Post-Liver Transplant Hepatitis C Virus Recurrence Using Serial Cluster of differentiation Antibody Microarrays. Transplantation, 99(9), e120-e126. [More Information]
- McCaughan, G., Bertolino, P., Bowen, D. (2015). Could the morning after liver transplant be immunologically interesting? Liver Transplantation, 21(9), 1120-1122. [More Information]
- Wong, Y., Tay, S., McCaughan, G., Bowen, D., Bertolino, P. (2015). Immune outcomes in the liver: Is CD8 T cell fate determined by the environment? Journal of Hepatology, 63(4), 1005-1014. [More Information]
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2014
- Prakoso, E., Tirnitz-Parker, J., Clouston, A., Kayali, Z., Lee, A., Gan, E., Ramm, G., Kench, J., Bowen, D., Olynyk, J., McCaughan, G., Shackel, N. (2014). Analysis of the intrahepatic ductular reaction and progenitor cell responses in hepatitis C virus recurrence after liver transplantation. Liver Transplantation, 20(12), 1508-1519. [More Information]
- Tay, S., Wong, Y., McDonald, D., Wood, N., Roediger, B., Sierro, F., McGuffog, C., Alexander, I., Bishop, A., Gamble, J., Weninger, W., McCaughan, G., Bertolino, P., Bowen, D. (2014). Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses. Proceedings of the National Academy of Sciences of the United States of America, 111(25), E2540-E2549. [More Information]
- Bowen, D., Bertolino, P. (2014). Immune Responses to the Hepatitis C Virus. In I. R. Mackay, N. R. Rose, B. Diamond, A. Davidson (Eds.), Encyclopedia of Medical Immunology: Autoimmune Diseases, (pp. 476-486). New York: Springer Science+Business Media. [More Information]
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2013
- Prakoso, E., Jones, C., Koorey, D., Strasser, S., Bowen, D., McCaughan, G., Shackel, N. (2013). Author reply: RE Terlipressin therapy for moderate to severe hyponatraemia in patients with liver failure. Internal Medicine Journal, 43(5), 607-607. [More Information]
- Tay, S., Lu, B., Sierro, F., Benseler, V., McGuffog, C., Bishop, A., Cowan, P., McCaughan, G., Dwyer, K., Bowen, D., et al (2013). Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation. Liver Transplantation, 19(11), 1224-1235. [More Information]
- Cunningham, E., Tay, S., Wang, C., Rtshiladze, M., Wang, Z., McGuffog, C., Cubitt, J., McCaughan, G., Alexander, I., Bertolino, P., Sharland, A., Bowen, D., Bishop, A. (2013). Gene therapy for tolerance: high-level expression of donor major histocompatibility complex in the liver overcomes naive and memory alloresponses to skin grafts. Transplantation, 95(1), 70-77. [More Information]
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2012
- Rahman, W., Huang, P., Belov, L., Chrisp, J., Christopherson, R., Stapelberg, P., Warner, F., George, J., Bowen, D., Strasser, S., Koorey, D., Sharland, A., McCaughan, G., Shackel, N. (2012). Analysis of human liver disease using a cluster of differentiation (CD) antibody microarray. Liver International, 32(10), 1527-1534. [More Information]
- Bowen, D. (2012). Finding a role for Th17 cells in hepatitis C pathogenesis. Journal of Gastroenterology and Hepatology, 27(2), 188-191. [More Information]
- Bowen, D. (2012). Immune Responses to HCV: Implications for Therapy. In Geoffrey W. McCaughan, John G. McHutchison, Jean-Michel Pawlotsky (Eds.), Advanced Therapy for Hepatitis C, (pp. 17-24). Chichester, United Kingdom: Wiley-Blackwell Publishing. [More Information]
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2011
- Wood, N., Linn, M., Bowen, D. (2011). Exhausted or just sleeping: Awakening virus-specific responses in chronic hepatitis C virus infection. Hepatology, 54(5), 1879-1882. [More Information]
- Benseler, V., Warren, A., Vo, M., Holz, L., Tay, S., Le Couteur, D., Breen, E., Allison, A., Van Rooijen, N., McGuffog, C., Bowen, D., McCaughan, G., Bertolino, P., et al (2011). Hepatocyte entry leads to degradation of autoreactive CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America, 108(40), 16735-16740. [More Information]
- McCaughan, G., Shackel, N., Bowen, D. (2011). Liver transplantation and hepatitis C: will understanding the interleukin-28B polymorphisms improve outcomes? Liver Transplantation, 17(3), 219-221. [More Information]
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2010
- Holz, L., Warren, A., Le Couteur, D., Bowen, D., Bertolino, P. (2010). CD8+ T cell tolerance following antigen recognition on hepatocytes. Journal of Autoimmunity, 34(1), 15-22. [More Information]
- Holz, L., Bowen, D., Bertolino, P. (2010). Mechanisms of T cell death in the liver: to Bim or not to Bim? Digestive Diseases, 28(1), 14-24. [More Information]
- Fuller, M., Shoukry, N., Gushima, T., Bowen, D., Callendret, B., Campbell, K., Hasselschwert, D., Hughes, A., Walker, C. (2010). Selection-driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection. Hepatology, 51(2), 378-387. [More Information]
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2009
- McCaughan, G., Shackel, N., Bertolino, P., Bowen, D. (2009). Molecular and cellular aspects of hepatitis C virus reinfection after liver transplantation: how the early phase impacts on outcomes. Transplantation, 87(8), 1105-1111. [More Information]
- Bowen, D., Zekry, A., Bertolino, P., Shackel, N., McCaughan, G. (2009). Pathology and pathogenesis of hepatitis C. In G. Dore, M. Temple-Smith, A. Lloyd (Eds.), Hepatitis C: An Expanding Perspective, (pp. 43-75). East Hawthorn, Victoria: IP Communications.
- Velazquez, V., Bowen, D., Walker, C. (2009). Silencing of T lymphocytes by antigen-driven programmed death in recombinant adeno-associated virus vector-mediated gene therapy. Blood, 113(3), 538-545. [More Information]
2008
- Bertolino, P., McCaughan, G., Bowen, D. (2008). Immunological Parameters Influencing Adaptive Immune Responses to the Hepatitis C Virus. In Emilio Jirillo (Eds.), Hepatitis C Virus Disease: Immunobiology and Clinical Applications, (pp. 39-70). United States: Springer. [More Information]
- Holz, L., Benseler, V., Bowen, D., Bouillet, P., Strasser, A., O'Reilly, L., D'Avigdor, W., Bishop, A., McCaughan, G., Bertolino, P. (2008). Intrahepatic Murine CD8 T-Cell Activation Associates With a Distinct Phenotype Leading to Bim-Dependent Death. Gastroenterology, 135(3), 989-997. [More Information]
- Ramalingam, R., Meyer-Olson, D., Shoukry, N., Bowen, D., Walker, C., Kalams, S. (2008). Kinetic analysis by real-time PCR of Hepatitis C Virus (HCV)-specific T cells in peripheral blood and liver after challenge with HCV. Journal of Virology, 82(21), 10487-10492. [More Information]
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2007
- Bertolino, P., Bowen, D., Benseler, V. (2007). T cells in the liver: there is life beyond the graveyard. Hepatology, 45(6), 1580-1582. [More Information]
- Benseler, V., McCaughan, G., Schlitt, H., Bishop, A., Bowen, D., Bertolino, P. (2007). The liver: a special case in transplantation tolerance. Seminars in Liver Disease, 27(2), 194-213. [More Information]
2006
- Dahlke, M., Loi, R., Warren, A., Holz, L., Popp, F., Weiss, D., Piso, P., Bowen, D., McCaughan, G., Schlitt, H., Bertolino, P. (2006). Immune-mediated hepatitis drives low-level fusion between hepatocytes and adult bone marrow cells. Journal of Hepatology, 44(2), 334-341. [More Information]
- Warren, A., Le Couteur, D., Fraser, R., Bowen, D., McCaughan, G., Bertolino, P. (2006). T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells. Hepatology, 44(5), 1182-1190. [More Information]
2005
- Bowen, D., Walker, C. (2005). Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature, 436(7053), 946-952. [More Information]
- Bertolino, P., Bowen, D., Zen, M., McCaughan, G. (2005). Autoimmune hepatitis in transgenic mouse models: what lessons can be learnt? In H. P. Dienes, U. Leuschner, A. W. Lohse, M. P. Manns (Eds.), Autoimmune Liver Disease: Proceedings of the Falk Symposium No. 142, (pp. 60-72). The Netherlands: Springer.
- Bertolino, P., Schrage, A., Bowen, D., Klugewitz, K., Ghani, S., Eulenburg, K., Holz, L., Hogg, N., McCaughan, G., Hamann, A. (2005). Early intrahepatic antigen-specific retention of naïve CD8+ T cells is predominantly ICAM-1/LFA-1 dependent in mice. Hepatology, 42(5), 1063-1071. [More Information]
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2004
- McCaughan, G., Bertolino, P., Bowen, D., Zen, M., Holz, L., Davis, T. (2004). The Site Of Primary T Cell Activation Is A Determinant Of The Balance Between Intrahepatic Tolerance And Immunity. Journal of Clinical Investigation, 114(5), 701-712. [More Information]
2002
- Bowen, D., Warren, A., Davis, T., Hoffmann, M., McCaughan, G., Fazekas de St Groth, B., Bertolino, P. (2002). Cytokine-dependent bystander hepatitis due to intrahepatic murine CD8+ T-cell activation by bone marrow-derived cells. Gastroenterology, 123(4), 1252-1264. [More Information]
- Zekry, A., Bishop, A., Bowen, D., Gleeson, M., Guney, S., Painter, D., McCaughan, G. (2002). Intrahepatic cytokine profiles associated with posttransplantation hepatitis C virus-related liver injury. Liver Transplantation, 8(3), 292-301. [More Information]
- Yan, Y., Putten, K., Bowen, D., Painter, D., Kohar, J., Sharland, A., McCaughan, G., Bishop, A. (2002). Postoperative administration of donor B cells induces rat kidney allograft acceptance: lack of association with TH2 cytokine expression in long-term accepted grafts. Transplantation, 73(7), 1123-1130. [More Information]
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2001
- Bertolino, P., Bowen, D., McCaughan, G., Fazekas de St Groth, B. (2001). Antigen-Specific Primary Activation of CD8(+) T Cells Within the Liver. Journal of Immunology, 166, 5430-5438.
- Yan, Y., Shastry, S., Richards, C., Wang, C., Bowen, D., Sharland, A., Painter, D., McCaughan, G., Bishop, A. (2001). Posttransplant administration of donor leukocytes induces long-term acceptance of kidney or liver transplants by an activation-associated immune mechanism. Journal of Immunology, 166, 5258-5264.
2000
- McCaughan, G., Gorrell, M., Bishop, A., Abbott, C., Shackel, N., McGuinness, P., Levy, M., Sharland, A., Bowen, D., Yu, M., Slaitini, L., Napoli, J., et al (2000). Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance. Immunological Reviews, 174(1), 172-191. [More Information]
Selected Grants
2017
- Protecting against malaria through liver-resident memory T cells, Bertolino P, Fernandez-Ruiz D, Bowen D, National Health and Medical Research Council (NHMRC)/Project Grants
- Deciphering how TCR affinity regulates CD4 T cell help in immunity and autoimmunity, Bertolino P, Feng C, Steptoe R, Bowen D, National Health and Medical Research Council (NHMRC)/Project Grants
2015
- Novel therapy approaches for diabetes and its liver and heart complications, Gorrell M, Keane F, Tu T, Shackel N, Bowen D, Bertolino P, Seth D, Chen J, Cook A, Liu R, Zheng X, Gamble J, McCaughan G, Rebecca L Cooper Medical Research Foundation/Research Support
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